SIMILAR PATTERNS OF AMINO ACIDS FOR 2VCV_F_ASDF1224

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE

(Gadus morhua) 		PF00171
(Aldedh) 		5 LEU A 270
PRO A 269
ALA A 449
LEU A 447
ALA A 444
 None
 1.22A 2vcvF-1a4sA:
0.0		 2vcvF-1a4sA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ae1 TROPINONE
REDUCTASE-I

(Datura
stramonium) 		PF13561
(adh_short_C2) 		5 PHE A 155
LEU A 145
LEU A 100
LEU A 137
ALA A 134
 None
 1.46A 2vcvF-1ae1A:
0.0		 2vcvF-1ae1A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aw1 TRIOSEPHOSPHATE
ISOMERASE

(Moritella
marina) 		PF00121
(TIM) 		4 PRO A 217
ALA A 237
ALA A 232
PHE A 224
 None
 0.82A 2vcvF-1aw1A:
0.0		 2vcvF-1aw1A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 PHE A 299
LEU A 269
LEU A 281
ALA A 155
PHE A  47
 None
 1.19A 2vcvF-1b41A:
0.0		 2vcvF-1b41A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7g TYROSINE
PHENOL-LYASE

(Pantoea
agglomerans) 		PF01212
(Beta_elim_lyase) 		4 LEU A 106
LEU A 267
ALA A 248
PHE A  90
 None
 0.91A 2vcvF-1c7gA:
0.0		 2vcvF-1c7gA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		4 PHE A 208
ALA A 297
LEU A 302
ALA A 211
 None
 0.86A 2vcvF-1c7jA:
0.0		 2vcvF-1c7jA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnv CONCANAVALIN B

(Canavalia
ensiformis) 		PF00704
(Glyco_hydro_18) 		4 LEU A  83
LEU A 172
ALA A 175
PHE A 181
 None
 0.87A 2vcvF-1cnvA:
0.0		 2vcvF-1cnvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ds9 OUTER ARM DYNEIN

(Chlamydomonas
reinhardtii) 		PF12799
(LRR_4) 		4 LEU A  53
LEU A  55
ALA A  22
ALA A  10
 None
 0.84A 2vcvF-1ds9A:
undetectable		 2vcvF-1ds9A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)

(Desulfovibrio
desulfuricans) 		PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9) 		5 PHE A 274
LEU A 258
PRO A 106
LEU A 134
ALA A 133
 None
 1.45A 2vcvF-1e08A:
0.0		 2vcvF-1e08A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb) 		5 LEU A  56
PRO A 199
LEU A 187
ALA A 177
PHE A 263
 None
 1.27A 2vcvF-1f0xA:
undetectable		 2vcvF-1f0xA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f99 R-PHYCOCYANIN

(Polysiphonia
urceolata) 		PF00502
(Phycobilisome) 		4 LEU A  24
ALA A   8
LEU A   5
ALA B  99
 PEB  B 355 ( 4.5A)
None
None
None
 0.90A 2vcvF-1f99A:
undetectable		 2vcvF-1f99A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g59 GLUTAMYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00749
(tRNA-synt_1c) 		4 LEU A 340
LEU A 348
ALA A 351
PHE A 365
 None
 0.77A 2vcvF-1g59A:
undetectable		 2vcvF-1g59A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE

(Rattus
norvegicus) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 LEU A 239
LEU A 243
ALA A 347
LEU A 354
 None
 0.75A 2vcvF-1gjvA:
undetectable		 2vcvF-1gjvA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A

(Sorghum bicolor) 		PF00450
(Peptidase_S10) 		4 LEU A  13
PRO A  17
LEU A  91
PHE A  22
 None
 0.90A 2vcvF-1gxsA:
undetectable		 2vcvF-1gxsA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 LEU A 488
LEU A 489
LEU A 402
ALA A 397
 None
 0.85A 2vcvF-1gytA:
undetectable		 2vcvF-1gytA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzj EGI

(Thermoascus
aurantiacus) 		PF00150
(Cellulase) 		4 LEU A 301
PRO A 303
ALA A 261
PHE A   4
 None
 0.80A 2vcvF-1gzjA:
undetectable		 2vcvF-1gzjA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipf TROPINONE
REDUCTASE-II

(Datura
stramonium) 		PF13561
(adh_short_C2) 		5 PHE A 143
LEU A 133
LEU A  88
LEU A 125
ALA A 122
 None
 1.45A 2vcvF-1ipfA:
undetectable		 2vcvF-1ipfA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 254
PRO A 252
ALA A 183
ALA A 136
 None
 0.84A 2vcvF-1itzA:
undetectable		 2vcvF-1itzA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME ALPHA
SUBUNIT

(Archaeoglobus
fulgidus) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 PHE A 175
LEU A 184
LEU A 194
ALA A 196
 None
 0.91A 2vcvF-1j2qA:
undetectable		 2vcvF-1j2qA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jik TYROSYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00579
(tRNA-synt_1b) 		5 PHE A 111
LEU A  46
LEU A 242
LEU A  55
PHE A 306
 None
545  A 421 ( 3.9A)
None
None
None
 1.36A 2vcvF-1jikA:
undetectable		 2vcvF-1jikA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwq N-ACETYLMURAMOYL-L-A
LANINE AMIDASE CWLV

(Paenibacillus
polymyxa) 		PF01520
(Amidase_3) 		4 PHE A 112
LEU A 146
LEU A 118
PHE A 160
 None
 0.90A 2vcvF-1jwqA:
undetectable		 2vcvF-1jwqA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD

(Escherichia
coli) 		PF00005
(ABC_tran) 		5 LEU C 176
LEU C 172
PRO C 160
LEU C  78
ALA C  76
 None
 1.39A 2vcvF-1l7vC:
undetectable		 2vcvF-1l7vC:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m22 PEPTIDE AMIDASE

(Stenotrophomonas
maltophilia) 		PF01425
(Amidase) 		4 LEU A 371
LEU A 385
ALA A 380
ALA A 139
 None
 0.86A 2vcvF-1m22A:
undetectable		 2vcvF-1m22A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A  30
ALA A  35
LEU A  56
ALA A  43
 None
 0.82A 2vcvF-1mdfA:
undetectable		 2vcvF-1mdfA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mkx PRETHROMBIN-2

(Bos taurus) 		PF00089
(Trypsin)
PF09396
(Thrombin_light) 		4 LEU K  14
LEU K 162
ALA K 183
PHE K 199
 None
 0.78A 2vcvF-1mkxK:
undetectable		 2vcvF-1mkxK:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN B

(Thermobifida
fusca) 		PF00079
(Serpin)
no annotation 		5 LEU A 219
ALA A  84
LEU A 162
ALA A 315
PHE B 354
 None
 1.28A 2vcvF-1mtpA:
undetectable		 2vcvF-1mtpA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 LEU A 382
LEU A 378
ALA A 351
LEU A 335
ALA A 344
 None
 1.47A 2vcvF-1nneA:
undetectable		 2vcvF-1nneA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odu PUTATIVE
ALPHA-L-FUCOSIDASE

(Thermotoga
maritima) 		PF01120
(Alpha_L_fucos) 		4 LEU A 323
LEU A 321
ALA A 117
LEU A 348
 None
 0.67A 2vcvF-1oduA:
undetectable		 2vcvF-1oduA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogk DEOXYURIDINE
TRIPHOSPHATASE

(Trypanosoma
cruzi) 		PF08761
(dUTPase_2) 		5 PHE A 188
LEU A  18
ALA A  79
LEU A 179
ALA A 183
 None
 1.31A 2vcvF-1ogkA:
undetectable		 2vcvF-1ogkA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT

(Propionibacterium
freudenreichii) 		PF01039
(Carboxyl_trans) 		4 PHE A 266
PRO A 402
ALA A 508
LEU A 504
 None
 0.88A 2vcvF-1on9A:
undetectable		 2vcvF-1on9A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9e METHYL PARATHION
HYDROLASE

(Pseudomonas sp.
WBC-3) 		PF00753
(Lactamase_B) 		4 LEU A 204
PRO A 206
LEU A 162
ALA A 163
 None
 0.82A 2vcvF-1p9eA:
undetectable		 2vcvF-1p9eA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		5 PHE A 242
LEU A 211
ALA A 208
LEU A 181
ALA A 197
 None
 1.33A 2vcvF-1pemA:
undetectable		 2vcvF-1pemA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 285
ALA A 131
LEU A 150
ALA A 281
 None
 0.88A 2vcvF-1pxtA:
undetectable		 2vcvF-1pxtA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 PHE A 108
LEU A 201
LEU A 146
ALA A 132
 None
 0.00A 2vcvF-1q5aA:
undetectable		 2vcvF-1q5aA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)

(Aspergillus
niger) 		PF00328
(His_Phos_2) 		4 PHE A 260
LEU A  80
ALA A 259
PHE A  97
 None
 0.88A 2vcvF-1qfxA:
undetectable		 2vcvF-1qfxA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 240
PRO A 238
ALA A 170
LEU A 178
ALA A 123
 None
 1.25A 2vcvF-1qgdA:
undetectable		 2vcvF-1qgdA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 662
ALA A 578
LEU A 571
ALA A 567
 None
 0.82A 2vcvF-1qgdA:
undetectable		 2vcvF-1qgdA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		4 LEU A 438
LEU A 442
LEU A 167
ALA A 166
 None
 0.76A 2vcvF-1qhbA:
undetectable		 2vcvF-1qhbA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
ALPHA-SUBUNIT

(Pseudomonas
putida) 		PF00676
(E1_dh)
PF12573
(OxoDH_E1alpha_N) 		4 LEU A 301
PRO A 299
ALA A 228
ALA A 191
 None
 0.87A 2vcvF-1qs0A:
undetectable		 2vcvF-1qs0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		4 PHE A 339
ALA A 391
LEU A 327
ALA A 337
 None
 0.87A 2vcvF-1r6vA:
undetectable		 2vcvF-1r6vA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 243
PRO A 241
ALA A 172
ALA A 125
 None
 0.91A 2vcvF-1tkcA:
undetectable		 2vcvF-1tkcA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU B 340
PRO B 339
LEU B 234
ALA B  82
 None
 0.88A 2vcvF-1tqyB:
undetectable		 2vcvF-1tqyB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		4 LEU A 417
ALA A 450
ALA A 395
PHE A 358
 None
 0.88A 2vcvF-1ulvA:
0.4		 2vcvF-1ulvA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usw FERULOYL ESTERASE A

(Aspergillus
niger) 		PF01764
(Lipase_3) 		4 ALA A 139
LEU A 141
ALA A 144
PHE A 168
 None
 0.87A 2vcvF-1uswA:
undetectable		 2vcvF-1uswA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		4 LEU A 420
LEU A 359
ALA A 358
PHE A 159
 None
 0.90A 2vcvF-1v4gA:
undetectable		 2vcvF-1v4gA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8d HYPOTHETICAL PROTEIN
(TT1679)

(Thermus
thermophilus) 		PF04260
(DUF436) 		5 LEU A  97
LEU A 101
PRO A  99
ALA A  51
LEU A  55
 None
 1.07A 2vcvF-1v8dA:
undetectable		 2vcvF-1v8dA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE

(Thermus
thermophilus) 		PF02219
(MTHFR) 		4 ALA A 259
LEU A 261
ALA A 264
PHE A 189
 None
 0.83A 2vcvF-1v93A:
undetectable		 2vcvF-1v93A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 LEU A 526
LEU A 510
ALA A 539
LEU A 537
PHE A 567
 None
 1.43A 2vcvF-1v9pA:
undetectable		 2vcvF-1v9pA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbr ENDO-1,4-BETA-XYLANA
SE B

(Thermotoga
maritima) 		PF00331
(Glyco_hydro_10) 		4 PHE A 796
LEU A 541
ALA A 551
PHE A 587
 None
 0.79A 2vcvF-1vbrA:
undetectable		 2vcvF-1vbrA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00218
(IGPS) 		5 LEU A 110
LEU A 133
ALA A 124
LEU A 121
ALA A 150
 None
 1.30A 2vcvF-1vc4A:
undetectable		 2vcvF-1vc4A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc9 NDX1

(Thermus
thermophilus) 		PF00293
(NUDIX) 		4 LEU A 108
LEU A 121
ALA A 120
PHE A  10
 None
 0.88A 2vcvF-1vc9A:
undetectable		 2vcvF-1vc9A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve1 O-ACETYLSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF00291
(PALP) 		4 LEU A  88
ALA A 136
LEU A 130
ALA A 127
 None
 0.90A 2vcvF-1ve1A:
undetectable		 2vcvF-1ve1A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE

(Thermotoga
maritima) 		PF02547
(Queuosine_synth) 		4 LEU A 273
LEU A 301
ALA A 304
PHE A 281
 None
 0.78A 2vcvF-1vkyA:
undetectable		 2vcvF-1vkyA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 LEU A 143
LEU A 144
ALA A 118
ALA A 101
 None
 0.80A 2vcvF-1vplA:
undetectable		 2vcvF-1vplA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		4 LEU C 719
PRO C 721
LEU C 687
ALA C 683
 None
 0.72A 2vcvF-1wa5C:
3.6		 2vcvF-1wa5C:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whs SERINE
CARBOXYPEPTIDASE II

(Triticum
aestivum) 		PF00450
(Peptidase_S10) 		4 LEU A   4
PRO A   8
LEU A  79
PHE A  14
 None
 0.84A 2vcvF-1whsA:
undetectable		 2vcvF-1whsA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wod MODA

(Escherichia
coli) 		PF13531
(SBP_bac_11) 		4 LEU A 115
LEU A 146
ALA A 155
ALA A 125
 None
None
None
WO4  A 234 ( 3.5A)
 0.87A 2vcvF-1wodA:
undetectable		 2vcvF-1wodA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x77 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF03358
(FMN_red) 		4 LEU A  10
LEU A  76
LEU A  91
ALA A  94
 None
 0.77A 2vcvF-1x77A:
undetectable		 2vcvF-1x77A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7h PUTATIVE KETOACYL
REDUCTASE

(Streptomyces
coelicolor) 		PF00106
(adh_short) 		4 LEU A  43
LEU A  73
ALA A  76
PHE A  34
 None
 0.88A 2vcvF-1x7hA:
undetectable		 2vcvF-1x7hA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		4 LEU A 246
LEU A 242
LEU A 407
ALA A 405
 None
 0.88A 2vcvF-1x9sA:
undetectable		 2vcvF-1x9sA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm9 PLAKOPHILIN 1

(Homo sapiens) 		PF00514
(Arm) 		4 LEU A 433
ALA A 527
LEU A 522
ALA A 550
 None
 0.90A 2vcvF-1xm9A:
1.4		 2vcvF-1xm9A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqa GLYOXALASE/BLEOMYCIN
RESISTANCE PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		4 LEU A   6
LEU A  20
ALA A  16
PHE A 106
 None
 0.86A 2vcvF-1xqaA:
undetectable		 2vcvF-1xqaA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqa GLYOXALASE/BLEOMYCIN
RESISTANCE PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		4 LEU A   8
LEU A   6
LEU A  26
PHE A  65
 None
 0.85A 2vcvF-1xqaA:
undetectable		 2vcvF-1xqaA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xre SUPEROXIDE DISMUTASE

(Bacillus
anthracis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 PHE A   4
LEU A  59
LEU A  62
LEU A  50
 None
 0.87A 2vcvF-1xreA:
undetectable		 2vcvF-1xreA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		4 LEU A 180
ALA A 140
ALA A  71
PHE A  27
 None
None
CYS  A 401 ( 4.7A)
CYS  A 401 (-4.6A)
 0.88A 2vcvF-1xt8A:
undetectable		 2vcvF-1xt8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y51 PHOSPHOCARRIER
PROTEIN HPR

(Geobacillus
stearothermophilus) 		PF00381
(PTS-HPr) 		4 LEU A  44
LEU A  35
ALA A  65
PHE A   6
 None
 0.90A 2vcvF-1y51A:
undetectable		 2vcvF-1y51A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum) 		PF12697
(Abhydrolase_6) 		4 LEU A 248
LEU A 253
ALA A 256
PHE A   7
 None
 0.87A 2vcvF-1y7iA:
undetectable		 2vcvF-1y7iA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF01717
(Meth_synt_2) 		5 LEU A 143
PRO A 140
ALA A 224
ALA A 172
PHE A  75
 None
 0.96A 2vcvF-1ypxA:
undetectable		 2vcvF-1ypxA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		4 ALA A 260
LEU A 143
ALA A 139
PHE A 169
 None
 0.89A 2vcvF-1ywfA:
undetectable		 2vcvF-1ywfA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yya TRIOSEPHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00121
(TIM) 		4 LEU A  40
PRO A  41
ALA A  49
LEU A  46
 None
 0.82A 2vcvF-1yyaA:
undetectable		 2vcvF-1yyaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z HUMAN COXSACKIEVIRUS
A21

(Enterovirus C) 		PF00073
(Rhv) 		5 LEU 3  99
PRO 3  88
LEU 3  86
ALA 3 167
PHE 3 115
 None
 1.48A 2vcvF-1z7z3:
undetectable		 2vcvF-1z7z3:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PHE A 350
LEU A 316
PRO A 346
LEU A 420
ALA A 417
 FAD  A 480 ( 4.8A)
FAD  A 480 (-3.7A)
None
None
None
 1.20A 2vcvF-2a8xA:
undetectable		 2vcvF-2a8xA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA

(Agrobacterium
fabrum) 		PF02464
(CinA) 		4 LEU A 163
LEU A 134
ALA A  89
LEU A  86
 None
 0.78A 2vcvF-2a9sA:
undetectable		 2vcvF-2a9sA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaf ARGININE DEIMINASE

(Pseudomonas
aeruginosa) 		PF02274
(Amidinotransf) 		4 LEU A  86
LEU A  90
ALA A 194
LEU A 190
 None
 0.88A 2vcvF-2aafA:
undetectable		 2vcvF-2aafA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE

(Thermotoga
maritima) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		4 LEU A 383
PRO A 379
ALA A 369
ALA A 397
 None
 0.90A 2vcvF-2b8nA:
undetectable		 2vcvF-2b8nA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgh VINORINE SYNTHASE

(Rauvolfia
serpentina) 		PF02458
(Transferase) 		4 PHE A 221
LEU A 397
ALA A 395
PHE A 350
 None
 0.90A 2vcvF-2bghA:
undetectable		 2vcvF-2bghA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		4 LEU A 198
ALA A 340
LEU A  14
ALA A  18
 None
 0.88A 2vcvF-2bi3A:
undetectable		 2vcvF-2bi3A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6x CITRATE SYNTHASE 1

(Bacillus
subtilis) 		PF00285
(Citrate_synt) 		5 LEU A 237
LEU A 247
LEU A 224
ALA A 282
PHE A 308
 None
COZ  A1365 (-4.3A)
None
None
None
 1.42A 2vcvF-2c6xA:
undetectable		 2vcvF-2c6xA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		5 LEU A 199
LEU A 235
ALA A 441
LEU A 439
PHE A 289
 None
 1.46A 2vcvF-2dkdA:
undetectable		 2vcvF-2dkdA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 LEU A 100
ALA A 242
LEU A 252
ALA A 248
 None
 0.91A 2vcvF-2douA:
undetectable		 2vcvF-2douA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 LEU A 228
LEU A 239
LEU A  47
ALA A  46
 None
 0.79A 2vcvF-2douA:
undetectable		 2vcvF-2douA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dst HYPOTHETICAL PROTEIN
TTHA1544

(Thermus
thermophilus) 		no annotation 5 LEU A   9
LEU A  14
PRO A  51
LEU A  66
ALA A  67
 None
 1.32A 2vcvF-2dstA:
undetectable		 2vcvF-2dstA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e11 HYDROLASE

(Xanthomonas
campestris) 		PF00795
(CN_hydrolase) 		4 LEU A 168
LEU A 170
ALA A 191
LEU A 187
 None
 0.79A 2vcvF-2e11A:
undetectable		 2vcvF-2e11A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehw HYPOTHETICAL PROTEIN
TTHB059

(Thermus
thermophilus) 		PF11483
(DUF3209) 		4 LEU A  61
LEU A  64
LEU A  41
ALA A   8
 None
 0.86A 2vcvF-2ehwA:
undetectable		 2vcvF-2ehwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eob 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
GAMMA 2

(Rattus
norvegicus) 		PF00017
(SH2) 		4 PHE A  85
LEU A 106
LEU A 100
ALA A  83
 None
 0.87A 2vcvF-2eobA:
undetectable		 2vcvF-2eobA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		4 PHE A 316
ALA A 303
LEU A 300
PHE A  70
 None
 0.84A 2vcvF-2fj0A:
undetectable		 2vcvF-2fj0A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fna CONSERVED
HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF01637
(ATPase_2) 		5 LEU A 126
LEU A 121
ALA A 159
LEU A 156
PHE A  76
 None
 1.35A 2vcvF-2fnaA:
undetectable		 2vcvF-2fnaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fna CONSERVED
HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF01637
(ATPase_2) 		5 PHE A 172
LEU A 126
LEU A 121
ALA A 159
LEU A 156
 None
 1.42A 2vcvF-2fnaA:
undetectable		 2vcvF-2fnaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		4 LEU A 134
ALA A  69
ALA A 111
PHE A 127
 MLY  A 133 (-4.0A)
None
None
None
 0.84A 2vcvF-2ftzA:
undetectable		 2vcvF-2ftzA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfp MULTIDRUG RESISTANCE
PROTEIN D

(Escherichia
coli) 		PF07690
(MFS_1) 		4 LEU A 216
LEU A 213
ALA A 221
LEU A  53
 None
 0.89A 2vcvF-2gfpA:
undetectable		 2vcvF-2gfpA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 PHE A 205
ALA A 251
LEU A 191
ALA A 203
 None
 0.88A 2vcvF-2gkoA:
undetectable		 2vcvF-2gkoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU

(Streptococcus
pneumoniae) 		PF01895
(PhoU) 		4 LEU A 134
LEU A 133
ALA A  27
PHE A 193
 None
 0.87A 2vcvF-2i0mA:
undetectable		 2vcvF-2i0mA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6b ADENOSINE KINASE

(Homo sapiens) 		PF00294
(PfkB) 		4 PHE A 193
LEU A 210
LEU A 180
ALA A 183
 None
 0.87A 2vcvF-2i6bA:
undetectable		 2vcvF-2i6bA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhn 3-METHYLADENINE
DNA-GLYCOSYLASE

(Archaeoglobus
fulgidus) 		PF00730
(HhH-GPD) 		4 LEU A 200
LEU A 197
ALA A 230
ALA A 125
 None
 0.83A 2vcvF-2jhnA:
undetectable		 2vcvF-2jhnA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjf L-LYSINE EPSILON
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		5 LEU A 218
PRO A 199
LEU A 163
ALA A 237
PHE A 235
 None
 1.42A 2vcvF-2jjfA:
undetectable		 2vcvF-2jjfA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzn MANNOSE-SPECIFIC
PHOSPHOTRANSFERASE
ENZYME IIA COMPONENT

(Escherichia
coli) 		PF03610
(EIIA-man) 		4 LEU A  98
LEU A 102
ALA A 118
LEU A 114
 None
 0.87A 2vcvF-2jznA:
undetectable		 2vcvF-2jznA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l52 METHANOSARCINA
ACETIVORANS SAMP1
HOMOLOG

(Methanosarcina
acetivorans) 		PF02597
(ThiS) 		4 PRO A  94
ALA A  12
LEU A  14
ALA A  17
 None
 0.89A 2vcvF-2l52A:
undetectable		 2vcvF-2l52A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A   9
LEU A   5
ALA A 288
LEU A  86
ALA A  85
 None
 1.24A 2vcvF-2ng1A:
undetectable		 2vcvF-2ng1A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6q VARIABLE LYMPHOCYTE
RECEPTOR A

(Eptatretus
burgeri) 		PF13855
(LRR_8) 		5 LEU A 232
LEU A 261
ALA A 267
LEU A 277
ALA A 250
 None
 1.01A 2vcvF-2o6qA:
undetectable		 2vcvF-2o6qA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 159
LEU A 135
LEU A  75
ALA A 105
 None
 0.88A 2vcvF-2ogaA:
undetectable		 2vcvF-2ogaA:
20.40