SIMILAR PATTERNS OF AMINO ACIDS FOR 2VCV_E_ASDE1224_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE
ALPHA CHAIN


(Sphingomonas
paucimobilis)
PF07746
(LigA)
5 LEU A  37
LEU A  61
ALA A  73
LEU A  75
PHE A  53
None
1.18A 2vcvE-1bouA:
0.0
2vcvE-1bouA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkd GROEL

(Escherichia
coli)
PF00118
(Cpn60_TCP1)
5 LEU A 221
LEU A 237
ALA A 275
LEU A 262
ALA A 258
None
1.15A 2vcvE-1dkdA:
undetectable
2vcvE-1dkdA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebv PROSTAGLANDIN H2
SYNTHASE


(Ovis aries)
PF00008
(EGF)
PF03098
(An_peroxidase)
5 PHE A 478
PRO A 172
LEU A 177
LEU A 494
PHE A 181
None
1.13A 2vcvE-1ebvA:
0.0
2vcvE-1ebvA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE


(Escherichia
coli)
PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb)
5 PRO A 199
LEU A 203
LEU A 187
ALA A 177
PHE A 263
None
0.96A 2vcvE-1f0xA:
0.0
2vcvE-1f0xA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g68 BETA-LACTAMASE PSE-4

(Pseudomonas
aeruginosa)
PF13354
(Beta-lactamase2)
5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
None
1.07A 2vcvE-1g68A:
0.0
2vcvE-1g68A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN


(Homo sapiens)
PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2)
5 PHE C 292
LEU C 376
LEU C 391
ALA C 394
PHE C 356
None
1.21A 2vcvE-1h2tC:
2.5
2vcvE-1h2tC:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htj KIAA0380

(Homo sapiens)
PF09128
(RGS-like)
5 LEU F 383
LEU F 369
ALA F 397
ALA F 346
PHE F 342
None
0.94A 2vcvE-1htjF:
0.1
2vcvE-1htjF:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihm CAPSID PROTEIN

(Norwalk virus)
PF00915
(Calici_coat)
PF08435
(Calici_coat_C)
5 LEU A1437
LEU A1233
LEU A1459
ALA A1457
PHE A1231
None
1.21A 2vcvE-1ihmA:
0.0
2vcvE-1ihmA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la1 GROEL

(Escherichia
coli)
PF00118
(Cpn60_TCP1)
5 LEU A 221
LEU A 237
ALA A 275
LEU A 262
ALA A 258
None
1.06A 2vcvE-1la1A:
0.0
2vcvE-1la1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE


(Leishmania
mexicana)
PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C)
5 LEU A 339
LEU A 321
ALA A 220
LEU A 233
ALA A 232
PLM  A 402 ( 4.9A)
None
PLM  A 402 ( 4.0A)
PLM  A 402 ( 4.3A)
PLM  A 402 ( 4.0A)
1.19A 2vcvE-1m66A:
undetectable
2vcvE-1m66A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n9b BETA-LACTAMASE SHV-2

(Klebsiella
pneumoniae)
PF13354
(Beta-lactamase2)
5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
None
1.02A 2vcvE-1n9bA:
undetectable
2vcvE-1n9bA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE


(Saccharomyces
cerevisiae)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 LEU A 285
LEU A 148
ALA A 131
LEU A 150
ALA A 281
None
1.09A 2vcvE-1pxtA:
undetectable
2vcvE-1pxtA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum)
PF00733
(Asn_synthase)
PF09147
(DUF1933)
5 LEU A 231
LEU A 227
ALA A 256
LEU A 253
PHE A 397
None
1.25A 2vcvE-1q15A:
undetectable
2vcvE-1q15A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txk GLUCANS BIOSYNTHESIS
PROTEIN G


(Escherichia
coli)
PF04349
(MdoG)
5 TYR A 218
PRO A 373
LEU A 372
LEU A 238
ALA A 214
None
1.14A 2vcvE-1txkA:
undetectable
2vcvE-1txkA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz6 PUTATIVE SUGAR
KINASE


(Salmonella
enterica)
PF00294
(PfkB)
5 PHE A 125
LEU A 132
ALA A 140
LEU A 142
ALA A 145
None
1.09A 2vcvE-1tz6A:
undetectable
2vcvE-1tz6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE


(Escherichia
coli)
PF04262
(Glu_cys_ligase)
5 LEU A 420
LEU A  12
LEU A 359
ALA A 358
PHE A 159
None
1.27A 2vcvE-1v4gA:
undetectable
2vcvE-1v4gA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb3 THREONINE SYNTHASE

(Escherichia
coli)
PF00291
(PALP)
PF14821
(Thr_synth_N)
5 LEU A 394
PRO A 397
LEU A 400
LEU A 104
ALA A 377
None
1.16A 2vcvE-1vb3A:
undetectable
2vcvE-1vb3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE


(Thermotoga
maritima)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 TYR A 260
LEU A 129
LEU A 214
LEU A 158
ALA A 157
None
1.26A 2vcvE-1vknA:
undetectable
2vcvE-1vknA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0m TRIOSEPHOSPHATE
ISOMERASE


(Thermoproteus
tenax)
PF00121
(TIM)
PF05690
(ThiG)
5 LEU A 218
PRO A 221
LEU A 222
LEU A 192
ALA A 191
None
1.26A 2vcvE-1w0mA:
undetectable
2vcvE-1w0mA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wv9 RHODANESE HOMOLOG
TT1651


(Thermus
thermophilus)
no annotation 5 PRO A   6
LEU A   9
ALA A  89
LEU A  83
PHE A  34
None
1.23A 2vcvE-1wv9A:
undetectable
2vcvE-1wv9A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls ORPHAN NUCLEAR
RECEPTOR NR1I3


(Mus musculus)
PF00104
(Hormone_recep)
5 LEU E 123
LEU E 189
LEU E 277
ALA E 273
PHE E 185
None
1.22A 2vcvE-1xlsE:
undetectable
2vcvE-1xlsE:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU B 113
LEU B 179
LEU B 267
ALA B 263
PHE B 175
None
1.29A 2vcvE-1xv9B:
1.4
2vcvE-1xv9B:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq3 SUCCINATE
DEHYDROGENASE IP
SUBUNIT


(Gallus gallus)
PF13085
(Fer2_3)
PF13534
(Fer4_17)
5 LEU B 203
LEU B 212
ALA B 187
LEU B 184
ALA B 234
None
0.96A 2vcvE-1yq3B:
undetectable
2vcvE-1yq3B:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z HUMAN COXSACKIEVIRUS
A21


(Enterovirus C)
PF00073
(Rhv)
5 PRO 3  88
LEU 3  94
LEU 3  86
ALA 3 167
PHE 3 115
None
1.25A 2vcvE-1z7z3:
undetectable
2vcvE-1z7z3:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli)
PF13354
(Beta-lactamase2)
5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
None
1.02A 2vcvE-1zg4A:
undetectable
2vcvE-1zg4A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 PHE A 350
LEU A 316
PRO A 346
LEU A 420
ALA A 417
FAD  A 480 ( 4.8A)
FAD  A 480 (-3.7A)
None
None
None
1.25A 2vcvE-2a8xA:
undetectable
2vcvE-2a8xA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN


(Streptococcus
pneumoniae)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 PHE A 256
LEU A 121
LEU A 286
ALA A 258
PHE A 260
None
1.27A 2vcvE-2am2A:
undetectable
2vcvE-2am2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Sulfolobus
solfataricus)
PF00348
(polyprenyl_synt)
5 LEU A 186
LEU A 167
ALA A 173
LEU A 171
ALA A 128
None
1.20A 2vcvE-2azkA:
undetectable
2vcvE-2azkA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3t PROTEIN
METHYLTRANSFERASE
HEMK


(Escherichia
coli)
PF13847
(Methyltransf_31)
6 TYR A 255
LEU A 236
LEU A 116
LEU A 114
ALA A 227
PHE A 169
None
1.26A 2vcvE-2b3tA:
undetectable
2vcvE-2b3tA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgh VINORINE SYNTHASE

(Rauvolfia
serpentina)
PF02458
(Transferase)
5 PHE A 221
LEU A 348
LEU A 397
ALA A 395
PHE A 350
None
1.07A 2vcvE-2bghA:
undetectable
2vcvE-2bghA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE


(Thermus
thermophilus)
PF00155
(Aminotran_1_2)
5 LEU A 357
LEU A 361
ALA A 367
LEU A 365
ALA A 299
None
SO4  A 502 (-4.3A)
None
None
None
1.02A 2vcvE-2douA:
undetectable
2vcvE-2douA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ds2 SWEET PROTEIN
MABINLIN-2 CHAIN A
SWEET PROTEIN
MABINLIN-2 CHAIN B


(Capparis
masaikai)
PF00234
(Tryp_alpha_amyl)
no annotation
5 LEU B   7
LEU B  14
ALA A  17
LEU A  15
ALA B  29
None
1.24A 2vcvE-2ds2B:
undetectable
2vcvE-2ds2B:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7g RHA04620, PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Rhodococcus
jostii)
PF02909
(TetR_C)
5 LEU A 200
LEU A 122
ALA A 134
ALA A 139
PHE A  80
None
1.28A 2vcvE-2g7gA:
undetectable
2vcvE-2g7gA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9i HYPOTHETICAL PROTEIN

(Helicobacter
pylori)
PF05211
(NLBH)
5 TYR A 241
LEU A 141
LEU A 252
ALA A 248
PHE A 178
None
1.25A 2vcvE-2i9iA:
undetectable
2vcvE-2i9iA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
GAMMA-SUBUNIT


(Aromatoleum
aromaticum)
PF09459
(EB_dh)
5 PHE C 187
LEU C 177
ALA C  62
ALA C  95
PHE C  97
None
1.14A 2vcvE-2ivfC:
undetectable
2vcvE-2ivfC:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3


(Brevibacillus
brevis)
PF00550
(PP-binding)
PF00668
(Condensation)
5 PHE A 430
LEU A 418
LEU A 414
ALA A 378
PHE A 282
None
1.21A 2vcvE-2jgpA:
undetectable
2vcvE-2jgpA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E


(Homo sapiens)
PF00089
(Trypsin)
5 LEU A  46
ALA A 106
LEU A 108
ALA A  66
PHE A  68
None
1.22A 2vcvE-2oq5A:
undetectable
2vcvE-2oq5A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica)
PF00781
(DAGK_cat)
5 PRO A  92
LEU A  93
ALA A 112
LEU A 109
ALA A  24
None
1.19A 2vcvE-2p1rA:
undetectable
2vcvE-2p1rA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p90 HYPOTHETICAL PROTEIN
CGL1923


(Corynebacterium
glutamicum)
PF09754
(PAC2)
5 PRO A 110
LEU A  91
LEU A  32
ALA A 179
PHE A 119
None
1.21A 2vcvE-2p90A:
undetectable
2vcvE-2p90A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r77 PHOSPHATIDYLETHANOLA
MINE-BINDING
PROTEIN, PUTATIVE


(Plasmodium
falciparum)
PF01161
(PBP)
5 LEU A  46
PRO A  20
LEU A  42
LEU A  25
PHE A  35
None
1.24A 2vcvE-2r77A:
undetectable
2vcvE-2r77A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN


(Deinococcus
radiodurans)
PF00773
(RNB)
5 PHE A  75
PRO A 341
LEU A 348
ALA A 121
ALA A 125
None
0.94A 2vcvE-2r7dA:
undetectable
2vcvE-2r7dA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x66 PRNB

(Pseudomonas
fluorescens)
PF08933
(DUF1864)
5 LEU A 279
LEU A 299
ALA A 273
LEU A 236
PHE A 303
None
1.25A 2vcvE-2x66A:
undetectable
2vcvE-2x66A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeb SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL


(Sus scrofa)
PF13085
(Fer2_3)
PF13534
(Fer4_17)
5 LEU B 203
LEU B 212
ALA B 187
LEU B 184
ALA B 234
None
0.98A 2vcvE-3aebB:
undetectable
2vcvE-3aebB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N


(Rhodobacter
capsulatus)
PF00148
(Oxidored_nitro)
5 LEU A 117
LEU A 121
ALA A  85
LEU A  89
ALA A  72
None
1.29A 2vcvE-3aeuA:
undetectable
2vcvE-3aeuA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahx BETA-GLUCOSIDASE A

(Clostridium
cellulovorans)
PF00232
(Glyco_hydro_1)
5 PHE A 281
PRO A 167
LEU A 221
ALA A 194
ALA A 253
None
1.30A 2vcvE-3ahxA:
0.5
2vcvE-3ahxA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq2 6B PROTEIN

(Agrobacterium
vitis)
PF02027
(RolB_RolC)
5 LEU A  20
ALA A  27
LEU A  24
ALA A 133
PHE A 131
None
1.11A 2vcvE-3aq2A:
undetectable
2vcvE-3aq2A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfz UPF0100 PROTEIN
MJ1186


(Methanocaldococcus
jannaschii)
PF13531
(SBP_bac_11)
5 PRO A  51
LEU A 317
LEU A  48
ALA A  93
PHE A 115
None
1.15A 2vcvE-3cfzA:
undetectable
2vcvE-3cfzA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cij UPF0100 PROTEIN
AF_0094


(Archaeoglobus
fulgidus)
PF13531
(SBP_bac_11)
5 PRO A  46
LEU A 315
LEU A  43
ALA A  88
PHE A 110
None
1.18A 2vcvE-3cijA:
undetectable
2vcvE-3cijA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fds DNA POLYMERASE
SLIDING CLAMP C


(Sulfolobus
solfataricus)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
5 TYR D  56
PHE D  57
LEU D  16
LEU D 100
ALA D   4
None
1.28A 2vcvE-3fdsD:
undetectable
2vcvE-3fdsD:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs2 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE


(Brucella
melitensis)
PF00793
(DAHP_synth_1)
5 PHE A 236
LEU A 186
ALA A 227
LEU A 224
ALA A 200
None
1.16A 2vcvE-3fs2A:
undetectable
2vcvE-3fs2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7n LIPASE

(Penicillium
expansum)
PF01764
(Lipase_3)
5 TYR A 194
PHE A 162
PRO A 102
LEU A 137
ALA A 136
None
1.27A 2vcvE-3g7nA:
undetectable
2vcvE-3g7nA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE


(Homo sapiens)
PF03747
(ADP_ribosyl_GH)
5 LEU A 292
LEU A  43
ALA A 307
LEU A  17
ALA A  13
None
CL  A 360 (-4.7A)
None
None
None
1.21A 2vcvE-3hfwA:
undetectable
2vcvE-3hfwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE


(Homo sapiens)
PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2)
5 PHE A 505
LEU A 403
LEU A 414
ALA A 421
ALA A 518
None
1.30A 2vcvE-3ibjA:
undetectable
2vcvE-3ibjA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jab GAFB DOMAIN OF
PHOSPHODIESTERASE 2A


(Bos taurus)
PF01590
(GAF)
5 PHE B 505
LEU B 403
LEU B 414
ALA B 421
ALA B 518
None
1.16A 2vcvE-3jabB:
3.3
2vcvE-3jabB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kez PUTATIVE SUGAR
BINDING PROTEIN


(Bacteroides
vulgatus)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
5 TYR A  52
LEU A 205
LEU A 198
ALA A 218
LEU A 222
None
1.28A 2vcvE-3kezA:
1.3
2vcvE-3kezA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kio RIBONUCLEASE H2
SUBUNIT C


(Mus musculus)
PF08615
(RNase_H2_suC)
5 PRO C  33
LEU C  32
LEU C  68
ALA C  61
PHE C  48
None
1.13A 2vcvE-3kioC:
undetectable
2vcvE-3kioC:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkr COATOMER SUBUNIT
ALPHA


(Bos taurus)
PF06957
(COPI_C)
5 LEU B1034
PRO B1037
LEU B1038
LEU B 943
PHE B 959
None
1.09A 2vcvE-3mkrB:
1.1
2vcvE-3mkrB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nog DESIGNED ANKYRIN
REPEAT PROTEIN


(synthetic
construct)
PF00023
(Ank)
PF12796
(Ank_2)
5 LEU D 126
LEU D 133
ALA D 120
LEU D 117
ALA D 149
None
1.13A 2vcvE-3nogD:
undetectable
2vcvE-3nogD:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE


(Oryctolagus
cuniculus)
PF00365
(PFK)
5 LEU A 136
LEU A 156
LEU A 105
ALA A 101
PHE A 128
None
1.22A 2vcvE-3o8lA:
undetectable
2vcvE-3o8lA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Burkholderia
pseudomallei)
PF00155
(Aminotran_1_2)
5 PHE A 210
LEU A 236
LEU A  72
ALA A 208
PHE A 195
None
1.23A 2vcvE-3p1tA:
undetectable
2vcvE-3p1tA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3q MMOQ

(Methylococcus
capsulatus)
PF08668
(HDOD)
5 LEU A 207
PRO A 213
ALA A  87
ALA A 153
PHE A 237
None
1.10A 2vcvE-3p3qA:
undetectable
2vcvE-3p3qA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae)
PF01497
(Peripla_BP_2)
5 TYR A 340
LEU A 181
LEU A 161
LEU A 307
ALA A 306
None
1.17A 2vcvE-3pshA:
undetectable
2vcvE-3pshA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9d PROTEIN
CPN_0803/CP_1068/CPJ
0803/CPB0832


(Chlamydia
pneumoniae)
PF17435
(DUF5414)
5 LEU A  18
LEU A  10
ALA A  76
LEU A  69
PHE A  55
None
1.27A 2vcvE-3q9dA:
3.1
2vcvE-3q9dA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxz ENOYL-COA
HYDRATASE/ISOMERASE


(Mycobacteroides
abscessus)
PF00378
(ECH_1)
5 TYR A 127
LEU A  18
ALA A 100
LEU A  53
ALA A 113
None
1.13A 2vcvE-3qxzA:
undetectable
2vcvE-3qxzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re1 UROPORPHYRINOGEN-III
SYNTHETASE


(Pseudomonas
syringae group
genomosp. 3)
PF02602
(HEM4)
5 LEU A  18
LEU A   6
LEU A 247
ALA A 246
PHE A 214
None
1.24A 2vcvE-3re1A:
undetectable
2vcvE-3re1A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)


(Escherichia
coli)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF13193
(AMP-binding_C)
5 LEU A 305
LEU A 299
LEU A 290
ALA A 289
PHE A 265
None
1.02A 2vcvE-3rg2A:
undetectable
2vcvE-3rg2A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sir CASPASE

(Drosophila
melanogaster)
PF00656
(Peptidase_C14)
5 PHE A  58
LEU A 253
LEU A 215
LEU A 202
PHE A 134
None
1.20A 2vcvE-3sirA:
undetectable
2vcvE-3sirA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1


(Schizosaccharomyces
pombe)
no annotation 5 PHE B 734
LEU B 743
LEU B 757
ALA B 760
PHE B 767
None
1.04A 2vcvE-3tixB:
undetectable
2vcvE-3tixB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC


(Oryza sativa)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48)
5 LEU A 265
LEU A 256
LEU A 221
ALA A 186
PHE A 203
None
1.04A 2vcvE-3vu2A:
undetectable
2vcvE-3vu2A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdj ENCA BETA-LACTAMASE

(synthetic
construct)
PF13354
(Beta-lactamase2)
5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
None
1.02A 2vcvE-3zdjA:
undetectable
2vcvE-3zdjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1


(Serratia
fonticola)
PF13354
(Beta-lactamase2)
5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
None
1.00A 2vcvE-4ev4A:
undetectable
2vcvE-4ev4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN


(Legionella
pneumophila)
no annotation 6 PRO A 222
LEU A 336
ALA A 225
LEU A 338
ALA A 355
PHE A 359
None
1.34A 2vcvE-4eziA:
undetectable
2vcvE-4eziA:
22.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hj2 GLUTATHIONE
S-TRANSFERASE A1


(Homo sapiens)
PF00043
(GST_C)
PF02798
(GST_N)
6 TYR A   9
PHE A  10
LEU A 107
PRO A 110
LEU A 213
ALA A 216
LZ6  A 301 (-4.6A)
None
LZ6  A 301 (-4.4A)
LZ6  A 301 (-3.5A)
None
LZ6  A 301 ( 4.6A)
0.84A 2vcvE-4hj2A:
36.4
2vcvE-4hj2A:
90.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyq PHOSPHOLIPASE A1

(Streptomyces
albidoflavus)
PF13472
(Lipase_GDSL_2)
5 PHE A  48
LEU A 229
LEU A 140
ALA A  34
ALA A   7
None
1.14A 2vcvE-4hyqA:
undetectable
2vcvE-4hyqA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN


(Lactobacillus
acidophilus)
PF06100
(MCRA)
5 PHE A 178
LEU A 194
ALA A 201
LEU A 152
PHE A 169
None
1.18A 2vcvE-4ia5A:
undetectable
2vcvE-4ia5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 SILKWORM STORAGE
PROTEIN


(Bombyx mori)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
5 PHE A 105
LEU A 140
LEU A  25
ALA A 109
PHE A 121
None
1.26A 2vcvE-4l37A:
undetectable
2vcvE-4l37A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN


(Escherichia
coli)
PF00989
(PAS)
5 LEU C 268
LEU C 301
LEU C 303
ALA C 284
PHE C 275
None
1.30A 2vcvE-4lryC:
undetectable
2vcvE-4lryC:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2j AMINOTRANSFERASE

(Streptomyces
lavendulae)
PF00155
(Aminotran_1_2)
5 LEU A 291
LEU A 375
LEU A 345
ALA A 357
PHE A 317
None
1.11A 2vcvE-4m2jA:
undetectable
2vcvE-4m2jA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN


(Mus musculus)
PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C)
5 LEU A 144
PRO A 152
LEU A 232
LEU A 216
PHE A 247
None
None
None
PC1  A 506 (-4.2A)
None
1.28A 2vcvE-4m4dA:
undetectable
2vcvE-4m4dA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1


(Homo sapiens;
synthetic
construct)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
5 LEU A3792
LEU A3821
LEU A3724
ALA A3811
PHE A3817
None
1.22A 2vcvE-4rh7A:
undetectable
2vcvE-4rh7A:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3k UNCHARACTERIZED
PROTEIN PA3435


(Pseudomonas
aeruginosa)
PF00258
(Flavodoxin_1)
5 LEU A  52
LEU A 148
ALA A  32
LEU A  30
ALA A  28
None
1.29A 2vcvE-5b3kA:
undetectable
2vcvE-5b3kA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5r GASDERMIN-A3

(Mus musculus)
PF04598
(Gasdermin)
5 LEU A 296
PRO A 329
LEU A 328
LEU A 334
ALA A 338
None
1.26A 2vcvE-5b5rA:
undetectable
2vcvE-5b5rA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdk CHAPERONIN 60B1

(Chlamydomonas
reinhardtii)
PF00118
(Cpn60_TCP1)
5 LEU A  29
LEU A  45
ALA A  83
LEU A  70
ALA A  66
None
1.10A 2vcvE-5cdkA:
undetectable
2vcvE-5cdkA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e43 BETA-LACTAMASE

(Streptosporangium
roseum)
PF13354
(Beta-lactamase2)
5 PRO A 146
LEU A 163
LEU A 140
ALA A 136
PHE A  72
None
1.02A 2vcvE-5e43A:
undetectable
2vcvE-5e43A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa)
PF13354
(Beta-lactamase2)
5 PRO A 138
LEU A 155
LEU A 132
ALA A 128
PHE A  64
None
1.12A 2vcvE-5eoeA:
undetectable
2vcvE-5eoeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fql IDURONATE-2-SULFATAS
E


(Homo sapiens)
PF00884
(Sulfatase)
5 TYR A 122
PHE A 123
LEU A 439
LEU A 413
ALA A 414
None
1.29A 2vcvE-5fqlA:
undetectable
2vcvE-5fqlA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum)
PF00194
(Carb_anhydrase)
5 PHE A 116
LEU A 142
ALA A  75
ALA A 114
PHE A 132
None
1.22A 2vcvE-5hpjA:
undetectable
2vcvE-5hpjA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum)
PF00194
(Carb_anhydrase)
5 PHE A 116
LEU A 162
LEU A 146
ALA A  75
ALA A 114
None
1.29A 2vcvE-5hpjA:
undetectable
2vcvE-5hpjA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2


(Planctopirus
limnophila)
PF00891
(Methyltransf_2)
PF16864
(Dimerisation2)
5 LEU A  95
LEU A  71
ALA A  31
LEU A  29
ALA A  26
None
1.30A 2vcvE-5i2hA:
undetectable
2vcvE-5i2hA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
BIOSYNTHESIS PROTEIN
YBDZ
ENTEROBACTIN
SYNTHASE COMPONENT F


(Escherichia
coli)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF03621
(MbtH)
PF13193
(AMP-binding_C)
5 PHE B   7
PRO B  34
LEU B  33
ALA A 826
LEU B  17
None
1.21A 2vcvE-5ja1B:
undetectable
2vcvE-5ja1B:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1b WD REPEAT-CONTAINING
PROTEIN 48


(Homo sapiens)
PF00400
(WD40)
PF11816
(DUF3337)
5 LEU B 460
LEU B 390
LEU B 466
ALA B 469
PHE B 507
None
1.27A 2vcvE-5k1bB:
undetectable
2vcvE-5k1bB:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ll7 BETA-LACTAMASE

(Escherichia
coli)
no annotation 5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
None
1.09A 2vcvE-5ll7A:
undetectable
2vcvE-5ll7A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1


(Homo sapiens)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
5 LEU A4042
PRO A4040
LEU A4124
ALA A4141
LEU A4113
None
1.04A 2vcvE-5nugA:
undetectable
2vcvE-5nugA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1


(Homo sapiens)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
5 TYR A3176
PHE A3179
LEU A3536
LEU A3509
ALA A3512
None
1.30A 2vcvE-5nugA:
undetectable
2vcvE-5nugA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5o RNASE ADAPTER
PROTEIN RAPZ


(Escherichia
coli)
PF03668
(ATP_bind_2)
5 LEU A  82
PRO A  80
LEU A   3
LEU A  74
ALA A  70
None
1.13A 2vcvE-5o5oA:
undetectable
2vcvE-5o5oA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um8 GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1)
PF00516
(GP120)
5 LEU G 122
LEU G 193
ALA G 161
ALA G 174
PHE G 176
None
1.10A 2vcvE-5um8G:
undetectable
2vcvE-5um8G:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0s 60 KDA CHAPERONIN

(Escherichia
coli)
PF00118
(Cpn60_TCP1)
5 LEU A 221
LEU A 237
ALA A 275
LEU A 262
ALA A 258
None
1.03A 2vcvE-5w0sA:
undetectable
2vcvE-5w0sA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN


(Thermus
thermophilus)
no annotation 5 PHE A 163
LEU A  24
PRO A  26
LEU A 112
ALA A 113
None
1.13A 2vcvE-5xpgA:
undetectable
2vcvE-5xpgA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis)
no annotation 5 PHE A 644
LEU A 581
ALA A 587
LEU A 585
ALA A 613
None
1.05A 2vcvE-6co7A:
undetectable
2vcvE-6co7A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6


(Mus musculus)
no annotation 5 LEU A 145
LEU A 152
ALA A 139
LEU A 136
ALA A 163
None
1.19A 2vcvE-6cv9A:
3.8
2vcvE-6cv9A:
18.81