SIMILAR PATTERNS OF AMINO ACIDS FOR 2VCV_D_ASDD1224_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsg BETA LACTAMASE

(Streptomyces
albus) 		PF13354
(Beta-lactamase2) 		5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
 None
 1.24A 2vcvD-1bsgA:
0.0		 2vcvD-1bsgA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bta BARSTAR

(Bacillus
amyloliquefaciens) 		PF01337
(Barstar) 		5 LEU A  16
LEU A  37
LEU A  24
ALA A   3
PHE A  74
 None
 1.09A 2vcvD-1btaA:
undetectable		 2vcvD-1btaA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkd GROEL

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		5 LEU A 221
LEU A 237
ALA A 275
LEU A 262
ALA A 258
 None
 1.18A 2vcvD-1dkdA:
0.5		 2vcvD-1dkdA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpb DIHYDROLIPOYL-TRANSA
CETYLASE

(Azotobacter
vinelandii) 		PF00198
(2-oxoacid_dh) 		5 PRO A 468
LEU A 469
ALA A 530
LEU A 526
PHE A 449
 None
 0.99A 2vcvD-1dpbA:
undetectable		 2vcvD-1dpbA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 PHE A 478
PRO A 172
LEU A 177
LEU A 494
PHE A 181
 None
 1.10A 2vcvD-1ebvA:
0.3		 2vcvD-1ebvA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb) 		5 PRO A 199
LEU A 203
LEU A 187
ALA A 177
PHE A 263
 None
 0.99A 2vcvD-1f0xA:
0.0		 2vcvD-1f0xA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g68 BETA-LACTAMASE PSE-4

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
 None
 1.11A 2vcvD-1g68A:
0.0		 2vcvD-1g68A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A

(Sorghum bicolor) 		PF00450
(Peptidase_S10) 		5 LEU A  13
PRO A  17
LEU A  91
ALA A  79
PHE A  22
 None
 1.08A 2vcvD-1gxsA:
0.0		 2vcvD-1gxsA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		5 PHE C 292
LEU C 376
LEU C 391
ALA C 394
PHE C 356
 None
 1.18A 2vcvD-1h2tC:
2.2		 2vcvD-1h2tC:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htj KIAA0380

(Homo sapiens) 		PF09128
(RGS-like) 		5 LEU F 383
LEU F 369
ALA F 397
ALA F 346
PHE F 342
 None
 0.99A 2vcvD-1htjF:
undetectable		 2vcvD-1htjF:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihm CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		5 LEU A1437
LEU A1233
LEU A1459
ALA A1457
PHE A1231
 None
 1.24A 2vcvD-1ihmA:
undetectable		 2vcvD-1ihmA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izo CYTOCHROME P450
152A1

(Bacillus
subtilis) 		PF00067
(p450) 		5 LEU A 251
LEU A 377
LEU A 258
ALA A 257
PHE A 279
 None
 1.24A 2vcvD-1izoA:
undetectable		 2vcvD-1izoA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1b B-CELL LYMPHOMA
3-ENCODED PROTEIN

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU A 281
LEU A 288
ALA A 275
LEU A 272
ALA A 304
 None
 1.09A 2vcvD-1k1bA:
undetectable		 2vcvD-1k1bA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00117
(GATase) 		5 PRO H 175
LEU H 166
LEU H 173
ALA H 193
PHE H 130
 None
 1.14A 2vcvD-1ka9H:
undetectable		 2vcvD-1ka9H:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la1 GROEL

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		5 LEU A 221
LEU A 237
ALA A 275
LEU A 262
ALA A 258
 None
 1.07A 2vcvD-1la1A:
undetectable		 2vcvD-1la1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Leishmania
mexicana) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 LEU A 339
LEU A 321
ALA A 220
LEU A 233
ALA A 232
 PLM  A 402 ( 4.9A)
None
PLM  A 402 ( 4.0A)
PLM  A 402 ( 4.3A)
PLM  A 402 ( 4.0A)
 1.21A 2vcvD-1m66A:
undetectable		 2vcvD-1m66A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n9b BETA-LACTAMASE SHV-2

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
 None
 1.05A 2vcvD-1n9bA:
undetectable		 2vcvD-1n9bA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 285
LEU A 148
ALA A 131
LEU A 150
ALA A 281
 None
 1.18A 2vcvD-1pxtA:
undetectable		 2vcvD-1pxtA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		5 LEU A 231
LEU A 227
ALA A 256
LEU A 253
PHE A 397
 None
 1.21A 2vcvD-1q15A:
undetectable		 2vcvD-1q15A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vki HYPOTHETICAL PROTEIN
ATU3699

(Agrobacterium
fabrum) 		PF04073
(tRNA_edit) 		5 LEU A  16
LEU A 151
ALA A 157
LEU A 155
ALA A 111
 None
 1.13A 2vcvD-1vkiA:
undetectable		 2vcvD-1vkiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0m TRIOSEPHOSPHATE
ISOMERASE

(Thermoproteus
tenax) 		PF00121
(TIM)
PF05690
(ThiG) 		5 LEU A 218
PRO A 221
LEU A 222
LEU A 192
ALA A 191
 None
 1.18A 2vcvD-1w0mA:
undetectable		 2vcvD-1w0mA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wv9 RHODANESE HOMOLOG
TT1651

(Thermus
thermophilus) 		no annotation 5 PRO A   6
LEU A   9
ALA A  89
LEU A  83
PHE A  34
 None
 1.21A 2vcvD-1wv9A:
undetectable		 2vcvD-1wv9A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z HUMAN COXSACKIEVIRUS
A21

(Enterovirus C) 		PF00073
(Rhv) 		5 PRO 3  88
LEU 3  94
LEU 3  86
ALA 3 167
PHE 3 115
 None
 1.24A 2vcvD-1z7z3:
undetectable		 2vcvD-1z7z3:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
 None
 1.05A 2vcvD-1zg4A:
undetectable		 2vcvD-1zg4A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PHE A 350
LEU A 316
PRO A 346
LEU A 420
ALA A 417
 FAD  A 480 ( 4.8A)
FAD  A 480 (-3.7A)
None
None
None
 1.22A 2vcvD-2a8xA:
undetectable		 2vcvD-2a8xA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		5 LEU A 186
LEU A 167
ALA A 173
LEU A 171
ALA A 128
 None
 1.20A 2vcvD-2azkA:
2.1		 2vcvD-2azkA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3t PROTEIN
METHYLTRANSFERASE
HEMK

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		6 TYR A 255
LEU A 236
LEU A 116
LEU A 114
ALA A 227
PHE A 169
 None
 1.37A 2vcvD-2b3tA:
undetectable		 2vcvD-2b3tA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgh VINORINE SYNTHASE

(Rauvolfia
serpentina) 		PF02458
(Transferase) 		5 PHE A 221
LEU A 348
LEU A 397
ALA A 395
PHE A 350
 None
 1.11A 2vcvD-2bghA:
undetectable		 2vcvD-2bghA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cc1 BETA-LACTAMASE

(Mycolicibacterium
fortuitum) 		PF13354
(Beta-lactamase2) 		5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
 None
 1.18A 2vcvD-2cc1A:
undetectable		 2vcvD-2cc1A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE

(Anopheles
gambiae) 		PF00266
(Aminotran_5) 		5 PRO A 215
LEU A  60
ALA A 203
LEU A 268
ALA A 271
 None
 1.22A 2vcvD-2ch1A:
undetectable		 2vcvD-2ch1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 LEU A 357
LEU A 361
ALA A 367
LEU A 365
ALA A 299
 None
SO4  A 502 (-4.3A)
None
None
None
 0.99A 2vcvD-2douA:
undetectable		 2vcvD-2douA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqz R.ECL18KI

(Enterobacter
cloacae) 		PF09019
(EcoRII-C) 		5 TYR A 295
LEU A 161
ALA A 255
LEU A 252
ALA A 135
 None
 1.20A 2vcvD-2fqzA:
1.3		 2vcvD-2fqzA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
GAMMA-SUBUNIT

(Aromatoleum
aromaticum) 		PF09459
(EB_dh) 		5 PHE C 187
LEU C 177
ALA C  62
ALA C  95
PHE C  97
 None
 1.12A 2vcvD-2ivfC:
undetectable		 2vcvD-2ivfC:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6b NR1C

(Escherichia
coli) 		PF12796
(Ank_2) 		5 PRO A  78
LEU A  94
ALA A  70
LEU A  46
ALA A  66
 None
 1.21A 2vcvD-2l6bA:
undetectable		 2vcvD-2l6bA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU A  46
ALA A 106
LEU A 108
ALA A  66
PHE A  68
 None
 1.20A 2vcvD-2oq5A:
undetectable		 2vcvD-2oq5A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica) 		PF00781
(DAGK_cat) 		5 PRO A  92
LEU A  93
ALA A 112
LEU A 109
ALA A  24
 None
 1.22A 2vcvD-2p1rA:
undetectable		 2vcvD-2p1rA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2w CITRATE SYNTHASE

(Thermotoga
maritima) 		PF00285
(Citrate_synt) 		5 LEU A  98
ALA A 202
LEU A 203
ALA A 322
PHE A 122
 None
 1.02A 2vcvD-2p2wA:
undetectable		 2vcvD-2p2wA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2w CITRATE SYNTHASE

(Thermotoga
maritima) 		PF00285
(Citrate_synt) 		5 LEU A 195
LEU A  98
ALA A 202
LEU A 203
PHE A 122
 None
 1.05A 2vcvD-2p2wA:
undetectable		 2vcvD-2p2wA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p90 HYPOTHETICAL PROTEIN
CGL1923

(Corynebacterium
glutamicum) 		PF09754
(PAC2) 		5 PRO A 110
LEU A  91
LEU A  32
ALA A 179
PHE A 119
 None
 1.20A 2vcvD-2p90A:
undetectable		 2vcvD-2p90A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN

(Deinococcus
radiodurans) 		PF00773
(RNB) 		5 PHE A  75
PRO A 341
LEU A 348
ALA A 121
ALA A 125
 None
 0.89A 2vcvD-2r7dA:
undetectable		 2vcvD-2r7dA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x66 PRNB

(Pseudomonas
fluorescens) 		PF08933
(DUF1864) 		5 LEU A 279
LEU A 299
ALA A 273
LEU A 236
PHE A 303
 None
 1.24A 2vcvD-2x66A:
3.7		 2vcvD-2x66A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Methanosarcina
mazei) 		PF00875
(DNA_photolyase) 		5 LEU A 396
PRO A 392
LEU A 386
LEU A 333
ALA A 329
 None
 1.13A 2vcvD-2xryA:
undetectable		 2vcvD-2xryA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhy ATP:COB(I)ALAMIN
ADENOSYLTRANSFERASE,
PUTATIVE

(Burkholderia
thailandensis) 		PF01923
(Cob_adeno_trans) 		5 PRO A  55
LEU A  54
ALA A 169
LEU A 166
ALA A 115
 None
 1.16A 2vcvD-2zhyA:
undetectable		 2vcvD-2zhyA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		no annotation 5 LEU E 293
ALA E 296
LEU E 295
ALA E 301
PHE E 286
 None
 1.14A 2vcvD-3aoeE:
undetectable		 2vcvD-3aoeE:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq2 6B PROTEIN

(Agrobacterium
vitis) 		PF02027
(RolB_RolC) 		5 LEU A  20
ALA A  27
LEU A  24
ALA A 133
PHE A 131
 None
 1.09A 2vcvD-3aq2A:
undetectable		 2vcvD-3aq2A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfz UPF0100 PROTEIN
MJ1186

(Methanocaldococcus
jannaschii) 		PF13531
(SBP_bac_11) 		5 PRO A  51
LEU A 317
LEU A  48
ALA A  93
PHE A 115
 None
 1.13A 2vcvD-3cfzA:
undetectable		 2vcvD-3cfzA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cij UPF0100 PROTEIN
AF_0094

(Archaeoglobus
fulgidus) 		PF13531
(SBP_bac_11) 		5 PRO A  46
LEU A 315
LEU A  43
ALA A  88
PHE A 110
 None
 1.18A 2vcvD-3cijA:
undetectable		 2vcvD-3cijA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cou NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 16

(Homo sapiens) 		PF00293
(NUDIX) 		5 LEU A  46
PRO A  58
LEU A  77
ALA A  85
PHE A  88
 None
 1.06A 2vcvD-3couA:
undetectable		 2vcvD-3couA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj7 MAJOR ANTIGENIC
PEPTIDE PEB3

(Campylobacter
jejuni) 		PF13531
(SBP_bac_11) 		5 LEU A 234
ALA A  33
LEU A  34
ALA A  38
PHE A 230
 None
 1.23A 2vcvD-3fj7A:
undetectable		 2vcvD-3fj7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE

(Homo sapiens) 		PF03747
(ADP_ribosyl_GH) 		5 LEU A 292
LEU A  43
ALA A 307
LEU A  17
ALA A  13
 None
CL  A 360 (-4.7A)
None
None
None
 1.22A 2vcvD-3hfwA:
undetectable		 2vcvD-3hfwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 TYR A 401
LEU A 176
LEU A 197
ALA A 200
PHE A 247
 None
 1.20A 2vcvD-3iu1A:
undetectable		 2vcvD-3iu1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jab GAFB DOMAIN OF
PHOSPHODIESTERASE 2A

(Bos taurus) 		PF01590
(GAF) 		5 PHE B 505
LEU B 403
LEU B 414
ALA B 421
ALA B 518
 None
 1.17A 2vcvD-3jabB:
3.2		 2vcvD-3jabB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kio RIBONUCLEASE H2
SUBUNIT C

(Mus musculus) 		PF08615
(RNase_H2_suC) 		5 PRO C  33
LEU C  32
LEU C  68
ALA C  61
PHE C  48
 None
 1.20A 2vcvD-3kioC:
undetectable		 2vcvD-3kioC:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkr COATOMER SUBUNIT
ALPHA

(Bos taurus) 		PF06957
(COPI_C) 		5 LEU B1034
PRO B1037
LEU B1038
LEU B 943
PHE B 959
 None
 1.09A 2vcvD-3mkrB:
2.3		 2vcvD-3mkrB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nog DESIGNED ANKYRIN
REPEAT PROTEIN

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU D 126
LEU D 133
ALA D 120
LEU D 117
ALA D 149
 None
 1.10A 2vcvD-3nogD:
undetectable		 2vcvD-3nogD:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 LEU A 136
LEU A 156
LEU A 105
ALA A 101
PHE A 128
 None
 1.24A 2vcvD-3o8lA:
undetectable		 2vcvD-3o8lA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Burkholderia
pseudomallei) 		PF00155
(Aminotran_1_2) 		5 PHE A 210
LEU A 236
LEU A  72
ALA A 208
PHE A 195
 None
 1.19A 2vcvD-3p1tA:
undetectable		 2vcvD-3p1tA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3q MMOQ

(Methylococcus
capsulatus) 		PF08668
(HDOD) 		5 LEU A 207
PRO A 213
ALA A  87
ALA A 153
PHE A 237
 None
 1.10A 2vcvD-3p3qA:
undetectable		 2vcvD-3p3qA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae) 		PF01497
(Peripla_BP_2) 		5 TYR A 340
LEU A 181
LEU A 161
LEU A 307
ALA A 306
 None
 1.19A 2vcvD-3pshA:
undetectable		 2vcvD-3pshA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9d PROTEIN
CPN_0803/CP_1068/CPJ
0803/CPB0832

(Chlamydia
pneumoniae) 		PF17435
(DUF5414) 		5 LEU A  18
LEU A  10
ALA A  76
LEU A  69
PHE A  55
 None
 1.20A 2vcvD-3q9dA:
3.2		 2vcvD-3q9dA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxz ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 TYR A 127
LEU A  18
ALA A 100
LEU A  53
ALA A 113
 None
 1.16A 2vcvD-3qxzA:
undetectable		 2vcvD-3qxzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re1 UROPORPHYRINOGEN-III
SYNTHETASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02602
(HEM4) 		5 LEU A  18
LEU A   6
LEU A 247
ALA A 246
PHE A 214
 None
 1.22A 2vcvD-3re1A:
undetectable		 2vcvD-3re1A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sir CASPASE

(Drosophila
melanogaster) 		PF00656
(Peptidase_C14) 		5 PHE A  58
LEU A 253
LEU A 215
LEU A 202
PHE A 134
 None
 1.23A 2vcvD-3sirA:
undetectable		 2vcvD-3sirA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 5 PHE B 734
LEU B 743
LEU B 757
ALA B 760
PHE B 767
 None
 1.09A 2vcvD-3tixB:
undetectable		 2vcvD-3tixB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubr CYTOCHROME C-552

(Shewanella
oneidensis) 		PF02335
(Cytochrom_C552) 		5 LEU A  75
LEU A 247
ALA A  82
LEU A 437
ALA A 433
 None
 1.11A 2vcvD-3ubrA:
undetectable		 2vcvD-3ubrA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 LEU A 265
LEU A 256
LEU A 221
ALA A 186
PHE A 203
 None
 1.01A 2vcvD-3vu2A:
undetectable		 2vcvD-3vu2A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdj ENCA BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
 None
 1.05A 2vcvD-3zdjA:
undetectable		 2vcvD-3zdjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 TYR A 401
LEU A 176
LEU A 197
ALA A 200
PHE A 247
 None
 1.22A 2vcvD-4c2xA:
undetectable		 2vcvD-4c2xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6y BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
 None
 1.14A 2vcvD-4c6yA:
undetectable		 2vcvD-4c6yA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c75 BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
 None
 1.13A 2vcvD-4c75A:
undetectable		 2vcvD-4c75A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola) 		PF13354
(Beta-lactamase2) 		5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
 None
 1.03A 2vcvD-4ev4A:
undetectable		 2vcvD-4ev4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 6 PRO A 222
LEU A 336
ALA A 225
LEU A 338
ALA A 355
PHE A 359
 None
 1.37A 2vcvD-4eziA:
undetectable		 2vcvD-4eziA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 TYR A 465
LEU A 395
ALA A 387
LEU A 383
ALA A 423
 None
 1.12A 2vcvD-4fddA:
3.4		 2vcvD-4fddA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9s INHIBITOR OF G-TYPE
LYSOZYME

(Escherichia
coli) 		PF04151
(PPC) 		5 LEU B  75
ALA B 103
LEU B 101
ALA B  56
PHE B  54
 None
 1.23A 2vcvD-4g9sB:
undetectable		 2vcvD-4g9sB:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02759
(RUN) 		5 LEU A  12
LEU A 175
ALA A  58
LEU A  59
PHE A 137
 None
 1.24A 2vcvD-4giwA:
undetectable		 2vcvD-4giwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glx DNA LIGASE

(Escherichia
coli) 		PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 LEU A 576
LEU A 535
ALA A 514
LEU A 512
PHE A 564
 None
 1.24A 2vcvD-4glxA:
2.5		 2vcvD-4glxA:
16.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		6 TYR A   9
PHE A  10
LEU A 107
PRO A 110
LEU A 213
ALA A 216
 LZ6  A 301 (-4.6A)
None
LZ6  A 301 (-4.4A)
LZ6  A 301 (-3.5A)
None
LZ6  A 301 ( 4.6A)
 0.79A 2vcvD-4hj2A:
36.5		 2vcvD-4hj2A:
90.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyq PHOSPHOLIPASE A1

(Streptomyces
albidoflavus) 		PF13472
(Lipase_GDSL_2) 		5 PHE A  48
LEU A 229
LEU A 140
ALA A  34
ALA A   7
 None
 1.14A 2vcvD-4hyqA:
undetectable		 2vcvD-4hyqA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		5 PHE A 178
LEU A 194
ALA A 201
LEU A 152
PHE A 169
 None
 1.20A 2vcvD-4ia5A:
1.0		 2vcvD-4ia5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 LEU A 355
ALA A 206
LEU A 207
ALA A 211
PHE A 351
 None
 1.17A 2vcvD-4l87A:
undetectable		 2vcvD-4l87A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2j AMINOTRANSFERASE

(Streptomyces
lavendulae) 		PF00155
(Aminotran_1_2) 		5 LEU A 291
LEU A 375
LEU A 345
ALA A 357
PHE A 317
 None
 1.12A 2vcvD-4m2jA:
undetectable		 2vcvD-4m2jA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mll BETA-LACTAMASE OXA-1

(Escherichia
coli) 		PF00905
(Transpeptidase) 		5 PHE A  69
LEU A 184
LEU A  75
ALA A  72
PHE A 175
 None
 1.20A 2vcvD-4mllA:
undetectable		 2vcvD-4mllA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 PHE A 359
LEU A 612
LEU A 255
ALA A 394
LEU A 395
 None
 1.17A 2vcvD-4n78A:
4.5		 2vcvD-4n78A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		5 PHE A 277
LEU A 233
ALA A 268
LEU A 269
PHE A  80
 None
 1.24A 2vcvD-4wxbA:
0.8		 2vcvD-4wxbA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaj MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR
RECEPTOR SUBFAMILY 2
GROUP E MEMBER 1

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		5 LEU A1346
LEU A1288
LEU A1228
ALA A1231
PHE A1285
 None
 1.21A 2vcvD-4xajA:
undetectable		 2vcvD-4xajA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		5 PRO A 275
LEU A 292
LEU A 269
ALA A 265
PHE A 202
 None
 1.08A 2vcvD-5aqaA:
undetectable		 2vcvD-5aqaA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdk CHAPERONIN 60B1

(Chlamydomonas
reinhardtii) 		PF00118
(Cpn60_TCP1) 		5 LEU A  29
LEU A  45
ALA A  83
LEU A  70
ALA A  66
 None
 1.10A 2vcvD-5cdkA:
undetectable		 2vcvD-5cdkA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e43 BETA-LACTAMASE

(Streptosporangium
roseum) 		PF13354
(Beta-lactamase2) 		5 PRO A 146
LEU A 163
LEU A 140
ALA A 136
PHE A  72
 None
 1.05A 2vcvD-5e43A:
undetectable		 2vcvD-5e43A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		5 PRO A 138
LEU A 155
LEU A 132
ALA A 128
PHE A  64
 None
 1.15A 2vcvD-5eoeA:
undetectable		 2vcvD-5eoeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
BIOSYNTHESIS PROTEIN
YBDZ
ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF03621
(MbtH)
PF13193
(AMP-binding_C) 		5 PHE B   7
PRO B  34
LEU B  33
ALA A 826
LEU B  17
 None
 1.17A 2vcvD-5ja1B:
undetectable		 2vcvD-5ja1B:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1b WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40)
PF11816
(DUF3337) 		5 LEU B 460
LEU B 390
LEU B 466
ALA B 469
PHE B 507
 None
 1.22A 2vcvD-5k1bB:
undetectable		 2vcvD-5k1bB:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ll7 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
 None
 1.13A 2vcvD-5ll7A:
undetectable		 2vcvD-5ll7A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 LEU A4042
PRO A4040
LEU A4124
ALA A4141
LEU A4113
 None
 1.04A 2vcvD-5nugA:
undetectable		 2vcvD-5nugA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti8 AMINOTRANSFERASE

(Pseudomonas sp.
M1) 		PF00202
(Aminotran_3) 		5 LEU A 445
PRO A 369
LEU A 453
ALA A 452
PHE A 395
 None
 1.24A 2vcvD-5ti8A:
undetectable		 2vcvD-5ti8A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Mycobacterium
tuberculosis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 PRO D 546
LEU D 545
ALA D 551
LEU D 547
PHE D 455
 None
 1.11A 2vcvD-5uheD:
undetectable		 2vcvD-5uheD:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um8 GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		5 LEU G 122
LEU G 193
ALA G 161
ALA G 174
PHE G 176
 None
 1.16A 2vcvD-5um8G:
undetectable		 2vcvD-5um8G:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0s 60 KDA CHAPERONIN

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		5 LEU A 221
LEU A 237
ALA A 275
LEU A 262
ALA A 258
 None
 1.03A 2vcvD-5w0sA:
undetectable		 2vcvD-5w0sA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		no annotation 5 PHE A 163
LEU A  24
PRO A  26
LEU A 112
ALA A 113
 None
 1.21A 2vcvD-5xpgA:
undetectable		 2vcvD-5xpgA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blj SERINE-TRNA LIGASE

(Naegleria
fowleri) 		no annotation 5 LEU A 359
ALA A 219
LEU A 220
ALA A 224
PHE A 355
 None
 1.08A 2vcvD-6bljA:
undetectable		 2vcvD-6bljA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis) 		no annotation 5 PHE A 644
LEU A 581
ALA A 587
LEU A 585
ALA A 613
 None
 1.08A 2vcvD-6co7A:
undetectable		 2vcvD-6co7A:
17.21