SIMILAR PATTERNS OF AMINO ACIDS FOR 2VCV_B_ASDB1224

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b74 GLUTAMATE RACEMASE

(Aquifex
pyrophilus) 		PF01177
(Asp_Glu_race) 		4 PHE A   6
LEU A  78
LEU A  52
ALA A  55
 None
 0.90A 2vcvB-1b74A:
2.2		 2vcvB-1b74A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dub 2-ENOYL-COA
HYDRATASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 PHE A 160
LEU A 218
ALA A 132
ALA A 138
 None
 0.88A 2vcvB-1dubA:
0.0		 2vcvB-1dubA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PHE A 422
LEU A 377
ALA A 407
ALA A 420
 None
 0.99A 2vcvB-1f8wA:
1.1		 2vcvB-1f8wA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME

(Homo sapiens) 		PF01536
(SAM_decarbox) 		4 PHE A  18
LEU A  91
LEU A  97
ALA A  98
 None
 0.98A 2vcvB-1jl0A:
0.0		 2vcvB-1jl0A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la1 GROEL

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		4 LEU A 221
ALA A 275
LEU A 262
ALA A 258
 None
 0.95A 2vcvB-1la1A:
0.0		 2vcvB-1la1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A  30
ALA A  35
LEU A  56
ALA A  43
 None
 0.89A 2vcvB-1mdfA:
0.8		 2vcvB-1mdfA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 LEU E 196
ALA E 190
LEU E 187
ALA E 220
 None
 0.82A 2vcvB-1nfiE:
1.0		 2vcvB-1nfiE:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 PHE A  98
ALA A 168
LEU A 169
ALA A  97
 None
 0.89A 2vcvB-1nowA:
0.0		 2vcvB-1nowA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 PHE A 142
LEU A  75
ALA A 136
ALA A 161
 None
 0.99A 2vcvB-1pgjA:
1.2		 2vcvB-1pgjA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 285
ALA A 131
LEU A 150
ALA A 281
 None
 0.93A 2vcvB-1pxtA:
undetectable		 2vcvB-1pxtA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51

(Pyrococcus
furiosus) 		PF08423
(Rad51)
PF14520
(HHH_5) 		4 LEU A  51
ALA A  61
LEU A  59
ALA A  88
 None
 0.97A 2vcvB-1pznA:
undetectable		 2vcvB-1pznA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1

(Homo sapiens) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		4 LEU A 215
ALA A 253
LEU A 250
ALA A 192
 None
 0.96A 2vcvB-1q8kA:
undetectable		 2vcvB-1q8kA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcw FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF01070
(FMN_dh) 		4 LEU A 454
PRO A 191
LEU A 422
ALA A 421
 None
 0.98A 2vcvB-1qcwA:
undetectable		 2vcvB-1qcwA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhf PROTEIN
(PHOSPHOGLYCERATE
MUTASE)

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		4 LEU A  52
PRO A  49
LEU A  42
ALA A  38
 None
 0.83A 2vcvB-1qhfA:
undetectable		 2vcvB-1qhfA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 PHE A 295
ALA A  73
LEU A  75
ALA A  78
 None
 0.91A 2vcvB-1r9jA:
undetectable		 2vcvB-1r9jA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rv9 CONSERVED
HYPOTHETICAL PROTEIN
NMB0706

(Neisseria
meningitidis) 		PF02578
(Cu-oxidase_4) 		4 LEU A  78
ALA A 133
LEU A 251
ALA A 110
 None
 0.96A 2vcvB-1rv9A:
undetectable		 2vcvB-1rv9A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		4 PHE A 223
LEU A 251
ALA A 258
LEU A 260
 None
 0.98A 2vcvB-1up2A:
undetectable		 2vcvB-1up2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve1 O-ACETYLSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF00291
(PALP) 		4 LEU A  88
ALA A 136
LEU A 130
ALA A 127
 None
 0.90A 2vcvB-1ve1A:
undetectable		 2vcvB-1ve1A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		4 PHE A 372
LEU A 394
ALA A 389
ALA A 362
 None
 0.85A 2vcvB-1vefA:
undetectable		 2vcvB-1vefA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxd SHIKIMATE
5-DEHYDROGENASE

(Thermus
thermophilus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 PHE A 196
LEU A 122
LEU A 215
ALA A 218
 None
 0.92A 2vcvB-1wxdA:
undetectable		 2vcvB-1wxdA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz8 ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		4 LEU A  75
ALA A 118
LEU A  42
ALA A  43
 MPD  A3003 (-4.7A)
MPD  A3003 ( 3.8A)
None
None
 0.97A 2vcvB-1wz8A:
undetectable		 2vcvB-1wz8A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz8 ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		4 PHE A  67
LEU A  96
PRO A 100
ALA A 109
 None
 0.91A 2vcvB-1wz8A:
undetectable		 2vcvB-1wz8A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x77 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF03358
(FMN_red) 		4 PHE A 156
LEU A 114
ALA A 167
ALA A 152
 None
None
None
FMN  A 200 ( 4.8A)
 0.81A 2vcvB-1x77A:
undetectable		 2vcvB-1x77A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF01717
(Meth_synt_2) 		4 PRO A 140
ALA A 224
LEU A 165
ALA A 162
 None
 0.97A 2vcvB-1ypxA:
undetectable		 2vcvB-1ypxA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		4 LEU A 132
ALA A 139
LEU A 141
ALA A 145
 None
 0.95A 2vcvB-1yt8A:
undetectable		 2vcvB-1yt8A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PHE A 350
LEU A 316
PRO A 346
LEU A 420
ALA A 417
 FAD  A 480 ( 4.8A)
FAD  A 480 (-3.7A)
None
None
None
 1.23A 2vcvB-2a8xA:
1.8		 2vcvB-2a8xA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkk DESIGNED ANKYRIN
REPEAT INHIBITOR
AR_3A

(synthetic
construct) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LEU B 126
ALA B 120
LEU B 117
ALA B 149
 None
 0.91A 2vcvB-2bkkB:
undetectable		 2vcvB-2bkkB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzn GMP REDUCTASE 2

(Homo sapiens) 		PF00478
(IMPDH) 		4 PHE A 266
ALA A  53
LEU A 245
ALA A 246
 None
IMP  A1338 (-3.4A)
None
None
 0.93A 2vcvB-2bznA:
undetectable		 2vcvB-2bznA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2di9 FILAMIN-B

(Homo sapiens) 		PF00630
(Filamin) 		4 LEU A  45
PRO A  92
ALA A  50
ALA A 116
 None
 0.97A 2vcvB-2di9A:
undetectable		 2vcvB-2di9A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 PHE A  65
ALA A 135
LEU A 136
ALA A  64
 None
 0.90A 2vcvB-2gjxA:
undetectable		 2vcvB-2gjxA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2)
no annotation 		4 PHE A  65
ALA I 135
LEU I 136
ALA A  64
 None
 0.98A 2vcvB-2gk1A:
undetectable		 2vcvB-2gk1A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 PHE A 409
LEU A 296
LEU A 420
ALA A 407
 None
 0.94A 2vcvB-2h2qA:
undetectable		 2vcvB-2h2qA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		4 PHE A 356
LEU A 243
ALA A 159
LEU A 163
 None
 0.97A 2vcvB-2h4tA:
undetectable		 2vcvB-2h4tA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE

(Cellulomonas
fimi) 		PF00331
(Glyco_hydro_10) 		4 PHE A 115
PRO A  21
ALA A  42
ALA A  67
 None
 0.92A 2vcvB-2hisA:
undetectable		 2vcvB-2hisA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l5v PROTEASOMAL
UBIQUITIN RECEPTOR
ADRM1

(Homo sapiens) 		PF16550
(RPN13_C) 		4 PHE A 377
LEU A 301
LEU A 361
ALA A 365
 None
 0.89A 2vcvB-2l5vA:
undetectable		 2vcvB-2l5vA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n2z NON-SPECIFIC
LIPID-TRANSFER
PROTEIN

(Anethum
graveolens) 		PF00234
(Tryp_alpha_amyl) 		4 LEU A  10
ALA A  49
LEU A   1
ALA A  39
 None
 0.93A 2vcvB-2n2zA:
undetectable		 2vcvB-2n2zA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 344
PRO A 290
ALA A 317
LEU A 320
 None
 0.70A 2vcvB-2og9A:
undetectable		 2vcvB-2og9A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		4 PHE A 209
LEU A 270
ALA A 251
ALA A 224
 None
 0.92A 2vcvB-2pkgA:
3.0		 2vcvB-2pkgA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE

(Pseudomonas
putida) 		PF00106
(adh_short) 		4 LEU A  70
ALA A 114
LEU A 110
ALA A  88
 None
 0.99A 2vcvB-2q2vA:
undetectable		 2vcvB-2q2vA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsj DNA-BINDING RESPONSE
REGULATOR, LUXR
FAMILY

(Ruegeria
pomeroyi) 		PF00072
(Response_reg) 		4 PHE A 125
ALA A 107
LEU A 112
ALA A 115
 None
 0.90A 2vcvB-2qsjA:
undetectable		 2vcvB-2qsjA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A 243
ALA A 103
LEU A  99
ALA A  34
 None
 0.96A 2vcvB-2r9lA:
undetectable		 2vcvB-2r9lA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1z ROP2

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		4 PHE A 325
LEU A 405
LEU A 321
ALA A 317
 None
 0.94A 2vcvB-2w1zA:
undetectable		 2vcvB-2w1zA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xen NI1C MUT4

(synthetic
construct) 		PF13857
(Ank_5) 		4 LEU A  60
ALA A  54
LEU A  51
ALA A  83
 EDO  A1104 (-4.5A)
None
None
None
 0.83A 2vcvB-2xenA:
undetectable		 2vcvB-2xenA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		4 PHE A 414
PRO A 350
LEU A 334
ALA A 337
 None
 0.75A 2vcvB-2xh1A:
undetectable		 2vcvB-2xh1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF00106
(adh_short) 		4 LEU A 193
ALA A  15
LEU A  12
ALA A  73
 None
None
NAP  A 500 (-4.0A)
NAP  A 500 (-4.1A)
 0.91A 2vcvB-2yutA:
undetectable		 2vcvB-2yutA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvx MG2+ TRANSPORTER
MGTE

(Thermus
thermophilus) 		PF00571
(CBS)
PF01769
(MgtE)
PF03448
(MgtE_N) 		4 LEU A 366
ALA A 401
LEU A 403
ALA A 406
 None
 0.94A 2vcvB-2yvxA:
undetectable		 2vcvB-2yvxA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 PHE A  86
LEU A  77
ALA A 138
LEU A  84
ALA A 117
 None
 1.45A 2vcvB-2yxzA:
undetectable		 2vcvB-2yxzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 LEU A 165
ALA A 102
LEU A 139
ALA A 142
 FPP  A1002 ( 4.6A)
FPP  A1002 (-4.1A)
None
None
 0.86A 2vcvB-3aq0A:
undetectable		 2vcvB-3aq0A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 LEU A 197
ALA A 102
LEU A 139
ALA A 142
 None
FPP  A1002 (-4.1A)
None
None
 0.86A 2vcvB-3aq0A:
undetectable		 2vcvB-3aq0A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		4 LEU B 174
ALA B  79
LEU B 116
ALA B 119
 None
2DE  B 329 ( 4.4A)
2DE  B 329 ( 4.6A)
None
 0.98A 2vcvB-3aqcB:
1.7		 2vcvB-3aqcB:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3avs LYSINE-SPECIFIC
DEMETHYLASE 6A

(Homo sapiens) 		PF02373
(JmjC) 		4 LEU A 956
PRO A1107
LEU A 977
ALA A 976
 None
 0.81A 2vcvB-3avsA:
undetectable		 2vcvB-3avsA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		PF00073
(Rhv)
no annotation 		4 LEU A 113
ALA B 103
LEU B 100
ALA B  48
 None
 0.92A 2vcvB-3cjiA:
undetectable		 2vcvB-3cjiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cou NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 16

(Homo sapiens) 		PF00293
(NUDIX) 		4 LEU A 140
PRO A  58
LEU A  77
ALA A  85
 None
 0.96A 2vcvB-3couA:
undetectable		 2vcvB-3couA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2n CYTOCHROME C
PEROXIDASE

(Pisum sativum;
Saccharomyces
cerevisiae) 		PF00141
(peroxidase) 		5 PHE A 259
LEU A 170
ALA A 108
LEU A  39
ALA A  43
 None
HEM  A 296 ( 4.8A)
None
None
None
 1.39A 2vcvB-3e2nA:
undetectable		 2vcvB-3e2nA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eak NBBCII10-FGLA

(Camelus
dromedarius) 		PF07686
(V-set) 		4 PHE A  40
ALA A  53
LEU A  37
ALA A 100
 None
 0.97A 2vcvB-3eakA:
undetectable		 2vcvB-3eakA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ep7 S-ADENOSYLMETHIONINE
DECARBOXYLASE ALPHA
CHAIN
S-ADENOSYLMETHIONINE
DECARBOXYLASE BETA
CHAIN

(Homo sapiens) 		PF01536
(SAM_decarbox) 		4 PHE B  18
LEU A  91
LEU A  97
ALA A  98
 None
 0.98A 2vcvB-3ep7B:
undetectable		 2vcvB-3ep7B:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 PHE A 331
PRO A 283
LEU A 269
ALA A 205
 None
 0.96A 2vcvB-3eyaA:
undetectable		 2vcvB-3eyaA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs2 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Brucella
melitensis) 		PF00793
(DAHP_synth_1) 		5 PHE A 236
LEU A 186
ALA A 227
LEU A 224
ALA A 200
 None
 1.17A 2vcvB-3fs2A:
undetectable		 2vcvB-3fs2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbh NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Staphylococcus
epidermidis) 		PF00881
(Nitroreductase) 		4 LEU A  78
ALA A 187
LEU A  85
ALA A  56
 None
 0.84A 2vcvB-3gbhA:
undetectable		 2vcvB-3gbhA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbp GALACTOSE-BINDING
PROTEIN

(Salmonella
enterica) 		PF13407
(Peripla_BP_4) 		4 LEU A  67
ALA A  98
LEU A  99
ALA A 105
 None
 0.96A 2vcvB-3gbpA:
undetectable		 2vcvB-3gbpA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvz UNCHARACTERIZED
PROTEIN CV2077

(Chromobacterium
violaceum) 		PF03417
(AAT) 		4 LEU A 218
ALA A  43
LEU A  41
ALA A  31
 None
 0.88A 2vcvB-3gvzA:
undetectable		 2vcvB-3gvzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 PHE C 260
LEU C 253
ALA C 267
ALA C 309
 None
 0.90A 2vcvB-3gzdC:
undetectable		 2vcvB-3gzdC:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 LEU A 549
ALA A 399
LEU A 396
ALA A 373
 None
NA  A 574 (-3.6A)
None
None
 0.99A 2vcvB-3hwwA:
undetectable		 2vcvB-3hwwA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ih6 PUTATIVE ZINC
PROTEASE

(Bordetella
pertussis) 		PF05193
(Peptidase_M16_C) 		4 LEU A 365
ALA A 301
LEU A 298
ALA A 339
 None
 0.96A 2vcvB-3ih6A:
undetectable		 2vcvB-3ih6A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Bacillus
cytotoxicus) 		PF13377
(Peripla_BP_3) 		4 LEU A 202
ALA A 230
LEU A 240
ALA A 236
 None
 0.98A 2vcvB-3k4hA:
undetectable		 2vcvB-3k4hA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd9 COENZYME A DISULFIDE
REDUCTASE

(Pyrococcus
horikoshii) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 374
ALA A 402
LEU A 385
ALA A 415
 None
 0.97A 2vcvB-3kd9A:
undetectable		 2vcvB-3kd9A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 PHE E 423
LEU E 247
ALA E 450
LEU E 447
 None
 0.69A 2vcvB-3kfuE:
undetectable		 2vcvB-3kfuE:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klb PUTATIVE
FLAVOPROTEIN

(Bacteroides
fragilis) 		PF12682
(Flavodoxin_4) 		4 LEU A  81
ALA A  30
LEU A  24
ALA A  21
 None
EDO  A 166 ( 4.6A)
None
None
 0.87A 2vcvB-3klbA:
undetectable		 2vcvB-3klbA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		4 PHE B 592
LEU B 621
ALA B 602
ALA B 633
 None
None
EDO  B 913 (-3.6A)
None
 0.81A 2vcvB-3l91B:
undetectable		 2vcvB-3l91B:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		4 LEU A 334
ALA A 485
LEU A 466
ALA A 469
 None
 0.91A 2vcvB-3m8uA:
undetectable		 2vcvB-3m8uA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 PHE A 168
LEU A 137
PRO A 208
LEU A 146
ALA A 171
 None
 1.41A 2vcvB-3mi9A:
undetectable		 2vcvB-3mi9A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mz1 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Sinorhizobium
meliloti) 		PF03466
(LysR_substrate) 		4 LEU A 245
ALA A 236
LEU A 224
ALA A 227
 None
 0.85A 2vcvB-3mz1A:
undetectable		 2vcvB-3mz1A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 PHE A 596
LEU A 662
LEU A 580
ALA A 567
 None
 0.99A 2vcvB-3nafA:
undetectable		 2vcvB-3nafA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nog DESIGNED ANKYRIN
REPEAT PROTEIN

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 LEU D 126
ALA D 120
LEU D 117
ALA D 149
 None
 0.99A 2vcvB-3nogD:
undetectable		 2vcvB-3nogD:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		4 PHE A 272
LEU A 285
LEU A 294
ALA A 297
 None
 0.96A 2vcvB-3o82A:
undetectable		 2vcvB-3o82A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pve AGRIN, AGRIN PROTEIN

(Mus musculus) 		PF00054
(Laminin_G_1) 		4 PHE A1461
LEU A1469
ALA A1628
ALA A1459
 None
 0.91A 2vcvB-3pveA:
undetectable		 2vcvB-3pveA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1t ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 LEU A  80
ALA A 123
LEU A  47
ALA A  48
 None
 0.99A 2vcvB-3q1tA:
undetectable		 2vcvB-3q1tA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsj NUDIX HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF00293
(NUDIX) 		4 LEU A 155
ALA A 203
LEU A 201
ALA A 179
 None
 0.95A 2vcvB-3qsjA:
undetectable		 2vcvB-3qsjA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE

(Pseudomonas
aeruginosa) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M)
PF14790
(THDPS_N) 		5 PHE A 170
LEU A 125
PRO A 100
ALA A 106
LEU A 131
 NPI  A 381 (-4.7A)
None
None
None
None
 1.39A 2vcvB-3r5bA:
undetectable		 2vcvB-3r5bA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb9 DNA POLYMERASE III
SUBUNIT BETA

(Mycobacterium
tuberculosis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 PHE A 261
LEU A 172
LEU A 178
ALA A 179
 None
 0.97A 2vcvB-3rb9A:
undetectable		 2vcvB-3rb9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb9 DNA POLYMERASE III
SUBUNIT BETA

(Mycobacterium
tuberculosis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 PHE A 301
LEU A 340
ALA A 363
ALA A 273
 None
 0.95A 2vcvB-3rb9A:
undetectable		 2vcvB-3rb9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE

(Ascaris suum) 		PF13085
(Fer2_3)
PF13534
(Fer4_17) 		4 LEU B 227
ALA B 211
LEU B 208
ALA B 258
 None
 0.96A 2vcvB-3vrbB:
undetectable		 2vcvB-3vrbB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak9 CPFTSY

(Physcomitrella
patens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU A 213
PRO A 181
LEU A 297
ALA A 296
 None
 0.94A 2vcvB-4ak9A:
undetectable		 2vcvB-4ak9A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c5n PHOSPHOMETHYLPYRIMID
INE KINASE

(Staphylococcus
aureus) 		PF08543
(Phos_pyr_kin) 		4 PHE A 102
LEU A  81
LEU A 130
ALA A 133
 None
 0.90A 2vcvB-4c5nA:
undetectable		 2vcvB-4c5nA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckg ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH)
PF16746
(BAR_3) 		4 PHE A 329
PRO A 257
LEU A 347
ALA A 342
 None
 0.89A 2vcvB-4ckgA:
1.9		 2vcvB-4ckgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn2 NITROREDUCTASE

(Geobacter
metallireducens) 		PF00881
(Nitroreductase) 		4 PHE A  16
ALA A  79
LEU A  83
ALA A  86
 None
FMN  A 300 (-3.3A)
None
None
 0.95A 2vcvB-4dn2A:
undetectable		 2vcvB-4dn2A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 PRO A 222
ALA A 225
LEU A 338
ALA A 355
 None
 0.95A 2vcvB-4eziA:
undetectable		 2vcvB-4eziA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		4 PHE A1219
LEU A1264
LEU A1134
ALA A1137
 None
 0.95A 2vcvB-4f0gA:
undetectable		 2vcvB-4f0gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN

(Hahella
chejuensis) 		PF02011
(Glyco_hydro_48) 		4 LEU A 488
ALA A 567
LEU A 564
ALA A 533
 None
 0.97A 2vcvB-4fusA:
undetectable		 2vcvB-4fusA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8s NITROREDUCTASE
FAMILY PROTEIN

(Geobacter
sulfurreducens) 		PF00881
(Nitroreductase) 		4 PHE A  16
ALA A  79
LEU A  83
ALA A  86
 None
FMN  A 300 (-3.4A)
None
None
 0.97A 2vcvB-4g8sA:
undetectable		 2vcvB-4g8sA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2

(Mus musculus) 		PF03372
(Exo_endo_phos) 		4 PHE A 126
LEU A 337
ALA A 293
ALA A 270
 None
 0.93A 2vcvB-4gz2A:
undetectable		 2vcvB-4gz2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 LEU N  89
ALA N  70
LEU N  67
ALA N  34
 None
 0.96A 2vcvB-4heaN:
0.9		 2vcvB-4heaN:
19.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 PHE A  10
LEU A 107
PRO A 110
LEU A 213
ALA A 216
 None
LZ6  A 301 (-4.4A)
LZ6  A 301 (-3.5A)
None
LZ6  A 301 ( 4.6A)
 0.80A 2vcvB-4hj2A:
36.4		 2vcvB-4hj2A:
90.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7z APOCYTOCHROME F

(Mastigocladus
laminosus) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 PHE C 129
LEU C 119
PRO C   2
ALA C  74
LEU C 115
 None
None
HEM  C 301 ( 3.7A)
HEM  C 301 (-4.8A)
None
 1.40A 2vcvB-4i7zC:
undetectable		 2vcvB-4i7zC:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 LEU A 285
ALA A 309
LEU A 306
ALA A 165
 None
 0.87A 2vcvB-4i93A:
1.1		 2vcvB-4i93A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		4 PHE A 320
LEU A 412
LEU A 348
ALA A 351
 None
 0.99A 2vcvB-4idmA:
undetectable		 2vcvB-4idmA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpd PROTEIN CYAY

(Burkholderia
cenocepacia) 		PF01491
(Frataxin_Cyay) 		4 PHE A 106
LEU A  33
ALA A  24
ALA A  96
 None
 0.98A 2vcvB-4jpdA:
undetectable		 2vcvB-4jpdA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 PRO A 119
ALA A 115
LEU A  75
ALA A  96
 None
 0.96A 2vcvB-4k9qA:
undetectable		 2vcvB-4k9qA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis) 		PF00532
(Peripla_BP_1) 		4 PHE A 220
ALA A 231
LEU A 170
ALA A 216
 None
 0.89A 2vcvB-4kzkA:
undetectable		 2vcvB-4kzkA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4la2 DIMETHYLSULPHONIOPRO
PIONATE (DMSP) LYASE
DDDQ

(Ruegeria
lacuscaerulensis) 		PF16867
(DMSP_lyase) 		4 PHE A 175
LEU A 107
LEU A   7
ALA A  10
 None
 0.92A 2vcvB-4la2A:
undetectable		 2vcvB-4la2A:
19.67