SIMILAR PATTERNS OF AMINO ACIDS FOR 2VCT_A_ASDA1223

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE

(Gadus morhua) 		PF00171
(Aldedh) 		4 ILE A 401
GLY A 403
LEU A 339
LEU A 345
 None
 0.73A 2vctA-1a4sA:
0.0		 2vctA-1a4sA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlk THROMBIN HEAVY CHAIN

(Bos taurus) 		PF00089
(Trypsin) 		4 ILE B 181
GLY B 211
LEU B 209
LEU B 123
 None
 0.86A 2vctA-1dlkB:
undetectable		 2vctA-1dlkB:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 ILE C 314
GLY C 321
LEU C 236
PHE C 241
 None
 0.79A 2vctA-1ea9C:
0.0		 2vctA-1ea9C:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		4 ILE A 429
GLY A 372
LEU A 415
PHE A 436
 None
PIN  A 506 ( 3.4A)
None
None
 0.72A 2vctA-1ecgA:
0.0		 2vctA-1ecgA:
18.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gul GLUTATHIONE
TRANSFERASE A4-4

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 TYR A   9
GLY A  14
ARG A  15
PHE A 111
 None
 0.54A 2vctA-1gulA:
33.5		 2vctA-1gulA:
54.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		4 ILE A 796
GLY A 802
LEU A 806
PHE A 570
 None
 0.81A 2vctA-1h7wA:
1.2		 2vctA-1h7wA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Aquifex
aeolicus) 		PF00885
(DMRL_synthase) 		4 ILE A  72
ARG A  68
LEU A 107
LEU A 103
 None
 0.71A 2vctA-1hqkA:
0.0		 2vctA-1hqkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyl HYPODERMA LINEATUM
COLLAGENASE

(Hypoderma
lineatum) 		PF00089
(Trypsin) 		4 ILE A 181
GLY A 211
LEU A 209
LEU A 123
 None
 0.78A 2vctA-1hylA:
undetectable		 2vctA-1hylA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 ILE A 508
LEU A 520
PHE A 445
PHE A 379
 None
 0.87A 2vctA-1j0hA:
0.0		 2vctA-1j0hA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ILE A 185
GLY A 186
LEU A 151
PHE A 425
 None
 0.83A 2vctA-1p43A:
undetectable		 2vctA-1p43A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ILE A 294
LEU A 128
LEU A 113
PHE A 110
PHE A 267
 None
 1.23A 2vctA-1svdA:
undetectable		 2vctA-1svdA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szq 2-METHYLCITRATE
DEHYDRATASE

(Escherichia
coli) 		PF03972
(MmgE_PrpD) 		4 ILE A 483
GLY A  78
LEU A  49
LEU A 447
 None
 0.86A 2vctA-1szqA:
undetectable		 2vctA-1szqA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tig TRANSLATION
INITIATION FACTOR 3

(Geobacillus
stearothermophilus) 		PF00707
(IF3_C) 		4 ILE A 132
GLY A 133
LEU A 137
LEU A 140
 None
 0.79A 2vctA-1tigA:
undetectable		 2vctA-1tigA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5t VPS36P
DEFECTIVE IN
VACUOLAR PROTEIN
SORTING

(Saccharomyces
cerevisiae) 		PF04157
(EAP30) 		4 TYR B 432
ILE B 434
LEU B 518
LEU B 514
 None
 0.89A 2vctA-1u5tB:
undetectable		 2vctA-1u5tB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		4 ILE A 130
GLY A  59
LEU A  60
LEU A 203
 None
 0.88A 2vctA-1v9cA:
undetectable		 2vctA-1v9cA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8t HYPOTHETICAL PROTEIN
RV0983

(Mycobacterium
tuberculosis) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 ILE A 158
GLY A 182
LEU A 180
LEU A 105
 None
 0.81A 2vctA-1y8tA:
undetectable		 2vctA-1y8tA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ya0 SMG-7 TRANSCRIPT
VARIANT 2

(Homo sapiens) 		PF10373
(EST1_DNA_bind)
PF10374
(EST1) 		4 ILE A 466
GLY A 463
LEU A 397
LEU A 396
 None
 0.67A 2vctA-1ya0A:
4.0		 2vctA-1ya0A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9n SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		4 ILE A 176
LEU A 137
PHE A  55
PHE A  69
 None
 0.87A 2vctA-1z9nA:
undetectable		 2vctA-1z9nA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 ILE A 258
GLY A 274
LEU A 280
LEU A 305
 None
 0.78A 2vctA-2b5mA:
undetectable		 2vctA-2b5mA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dej PROBABLE
GALACTOKINASE

(Pyrococcus
horikoshii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 ILE A  88
GLY A  87
LEU A  58
PHE A  75
 None
 0.72A 2vctA-2dejA:
undetectable		 2vctA-2dejA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f91 HEPATOPANCREAS
TRYPSIN

(Astacus
leptodactylus) 		PF00089
(Trypsin) 		4 ILE A 181
GLY A 211
LEU A 209
LEU A 123
 CD  A 405 ( 4.9A)
None
None
None
 0.86A 2vctA-2f91A:
undetectable		 2vctA-2f91A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9f PEPTIDE N-GLYCANASE

(Mus musculus) 		PF04721
(PAW) 		5 ILE A 511
GLY A 517
LEU A 477
PHE A 478
PHE A 490
 None
None
None
GOL  A 103 ( 4.7A)
None
 1.42A 2vctA-2g9fA:
undetectable		 2vctA-2g9fA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnp TRANSCRIPTIONAL
REGULATOR

(Streptococcus
pneumoniae) 		PF04198
(Sugar-bind) 		4 ILE A 210
GLY A 209
LEU A 121
LEU A 124
 None
 0.78A 2vctA-2gnpA:
undetectable		 2vctA-2gnpA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi9 PLASMA SERINE
PROTEASE INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		4 ILE A 249
LEU A 363
LEU A 280
PHE A 275
 None
 0.84A 2vctA-2hi9A:
undetectable		 2vctA-2hi9A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m3e INTEGRIN ALPHA-L

(Homo sapiens) 		PF00357
(Integrin_alpha) 		4 ILE A1073
GLY A1074
LEU A1078
LEU A1081
 None
 0.80A 2vctA-2m3eA:
undetectable		 2vctA-2m3eA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ncj UNCHARACTERIZED
PROTEIN

(Cronobacter
sakazakii) 		PF07445
(PriC) 		4 ILE A  21
GLY A  22
LEU A  46
LEU A  50
 None
 0.80A 2vctA-2ncjA:
2.6		 2vctA-2ncjA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfv EXOCYST COMPLEX
COMPONENT EXO70

(Saccharomyces
cerevisiae) 		PF03081
(Exo70) 		4 ILE A 472
GLY A 473
LEU A 477
LEU A 480
 None
 0.86A 2vctA-2pfvA:
4.9		 2vctA-2pfvA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 ILE A 195
GLY A 227
LEU A 229
PHE A 401
 None
 0.78A 2vctA-2qpmA:
undetectable		 2vctA-2qpmA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qza SECRETED EFFECTOR
PROTEIN

(Salmonella
enterica) 		PF13599
(Pentapeptide_4)
PF13979
(SopA_C)
PF13981
(SopA) 		4 ILE A 609
LEU A 689
PHE A 693
PHE A 651
 None
 0.84A 2vctA-2qzaA:
1.6		 2vctA-2qzaA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5x UNCHARACTERIZED
CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF08868
(YugN) 		4 ILE A  71
GLY A  57
ARG A  37
LEU A  74
 None
 0.81A 2vctA-2r5xA:
undetectable		 2vctA-2r5xA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 ILE B 384
LEU B 355
LEU B 353
PHE B 392
 None
 0.87A 2vctA-2v9tB:
undetectable		 2vctA-2v9tB:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbk TAILSPIKE-PROTEIN

(Shigella virus
Sf6) 		PF12708
(Pectate_lyase_3) 		4 GLY A 405
LEU A 398
LEU A 396
PHE A 415
 None
 0.87A 2vctA-2vbkA:
undetectable		 2vctA-2vbkA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xs2 DELETED IN
AZOOSPERMIA-LIKE

(Mus musculus) 		PF00076
(RRM_1) 		4 GLY A  46
LEU A 110
PHE A  43
PHE A  84
 None
None
U  B   4 ( 3.5A)
U  B   5 ( 3.5A)
 0.89A 2vctA-2xs2A:
undetectable		 2vctA-2xs2A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a18 ALDOXIME DEHYDRATASE

(Rhodococcus
erythropolis) 		PF13816
(Dehydratase_hem) 		4 TYR A 146
ILE A 162
GLY A  32
LEU A  38
 None
 0.86A 2vctA-3a18A:
undetectable		 2vctA-3a18A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 TYR A 542
GLY A 408
ARG A 410
LEU A 423
 None
 0.88A 2vctA-3aflA:
4.6		 2vctA-3aflA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526

(Sulfurisphaera
tokodaii) 		PF01300
(Sua5_yciO_yrdC)
PF03481
(SUA5) 		4 TYR A  38
ILE A 171
GLY A 173
LEU A  10
 None
 0.89A 2vctA-3ajeA:
undetectable		 2vctA-3ajeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		4 ILE A 240
GLY A 237
LEU A 287
LEU A 292
 None
 0.71A 2vctA-3axxA:
undetectable		 2vctA-3axxA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9i GITR LIGAND

(Mus musculus) 		no annotation 4 TYR A 136
ILE A  91
GLY A 133
LEU A 130
 None
 0.84A 2vctA-3b9iA:
undetectable		 2vctA-3b9iA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e79 HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37

(Mycoplasma
hyorhinis) 		PF06646
(Mycoplasma_p37) 		4 TYR A 162
ILE A 336
GLY A 165
PHE A 243
 None
 0.81A 2vctA-3e79A:
undetectable		 2vctA-3e79A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g04 THYROTROPIN RECEPTOR

(Homo sapiens) 		PF13306
(LRR_5) 		4 ILE C 158
LEU C 207
LEU C 213
PHE C 189
 None
 0.87A 2vctA-3g04C:
undetectable		 2vctA-3g04C:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf5 MAJOR VAULT PROTEIN

(Mus musculus) 		PF01505
(Vault) 		4 ILE A 380
GLY A 331
LEU A 326
LEU A 363
 None
 0.81A 2vctA-3gf5A:
undetectable		 2vctA-3gf5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gon PHOSPHOMEVALONATE
KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N) 		4 TYR A  11
ILE A  18
LEU A 139
PHE A 132
 PMV  A 400 (-4.0A)
PMV  A 400 (-4.6A)
None
None
 0.83A 2vctA-3gonA:
undetectable		 2vctA-3gonA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1n PROBABLE GLUTATHIONE
S-TRANSFERASE

(Bordetella
bronchiseptica) 		PF14497
(GST_C_3) 		4 TYR A   7
ILE A  11
GLY A  13
ARG A  14
 None
None
CL  A 234 (-3.6A)
None
 0.81A 2vctA-3h1nA:
20.8		 2vctA-3h1nA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1w MANNOSE-6-PHOSPHATE
ISOMERASE

(Salmonella
enterica) 		PF01238
(PMI_typeI) 		4 GLY A 276
LEU A 187
PHE A 184
PHE A 148
 EDO  A 393 ( 3.7A)
EDO  A 394 ( 4.0A)
EDO  A 394 (-4.3A)
None
 0.76A 2vctA-3h1wA:
undetectable		 2vctA-3h1wA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieh PUTATIVE
METALLOPEPTIDASE

(Shewanella
baltica) 		PF04952
(AstE_AspA) 		4 ILE A 165
GLY A 241
LEU A 269
PHE A 266
 None
 0.75A 2vctA-3iehA:
undetectable		 2vctA-3iehA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		4 TYR A 108
GLY A 352
LEU A 347
PHE A 324
 LEU  A 601 (-4.5A)
NA  A 751 ( 4.8A)
None
None
 0.83A 2vctA-3mpnA:
undetectable		 2vctA-3mpnA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0w ABC BRANCHED CHAIN
AMINO ACID FAMILY
TRANSPORTER,
PERIPLASMIC LIGAND
BINDING PROTEIN

(Paraburkholderia
xenovorans) 		PF13458
(Peripla_BP_6) 		4 GLY A 351
LEU A 347
LEU A 332
PHE A 329
 None
 0.70A 2vctA-3n0wA:
undetectable		 2vctA-3n0wA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9o PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF02373
(JmjC) 		4 GLY A 579
LEU A 484
LEU A 423
PHE A 498
 None
None
OGA  A   4 (-4.4A)
None
 0.73A 2vctA-3n9oA:
3.5		 2vctA-3n9oA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njp EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 ILE A 143
LEU A  80
LEU A  77
PHE A 126
 None
 0.83A 2vctA-3njpA:
undetectable		 2vctA-3njpA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1

(Anopheles
gambiae) 		PF00560
(LRR_1) 		4 ILE A 203
LEU A 173
LEU A 171
PHE A 183
 None
 0.80A 2vctA-3ojaA:
undetectable		 2vctA-3ojaA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		4 ILE A 147
GLY A 172
ARG A 171
LEU A  92
 None
 0.74A 2vctA-3sggA:
undetectable		 2vctA-3sggA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0o SELENIDE, WATER
DIKINASE

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ILE A 182
GLY A 181
LEU A 295
LEU A 296
 None
 0.69A 2vctA-3u0oA:
undetectable		 2vctA-3u0oA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2r REGULATORY PROTEIN
MARR

(Planctopirus
limnophila) 		PF01047
(MarR) 		4 GLY A  87
ARG A  86
LEU A  88
LEU A 112
 None
 0.80A 2vctA-3u2rA:
undetectable		 2vctA-3u2rA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgf MALTO-OLIGOSYLTREHAL
OSE TREHALOHYDROLASE

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF09071
(Alpha-amyl_C) 		5 TYR A 397
ILE A 473
GLY A 420
ARG A 387
LEU A 465
 None
 1.16A 2vctA-3vgfA:
undetectable		 2vctA-3vgfA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ILE A 711
LEU A 682
LEU A 680
PHE A 719
 None
 0.89A 2vctA-3wpeA:
undetectable		 2vctA-3wpeA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo0 E3 UBIQUITIN-PROTEIN
LIGASE TRIM21

(Mus musculus) 		PF00622
(SPRY)
PF13765
(PRY) 		4 ILE B 130
GLY B  79
LEU B  54
PHE B  59
 None
 0.80A 2vctA-3zo0B:
undetectable		 2vctA-3zo0B:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C

(Homo sapiens) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 ILE A 112
LEU A  83
LEU A  81
PHE A 120
 None
 0.85A 2vctA-3zyjA:
undetectable		 2vctA-3zyjA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE

(Homo sapiens) 		PF02668
(TauD)
PF06155
(DUF971) 		4 ILE A 289
GLY A 234
LEU A 320
PHE A 317
 None
 0.68A 2vctA-4bhiA:
undetectable		 2vctA-4bhiA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 ILE A 171
GLY A 203
LEU A 201
LEU A 113
 None
 0.81A 2vctA-4dgjA:
undetectable		 2vctA-4dgjA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffl PYLC

(Methanosarcina
barkeri) 		PF02655
(ATP-grasp_3) 		4 ILE A 322
ARG A 348
LEU A 352
LEU A 363
 None
 0.87A 2vctA-4fflA:
undetectable		 2vctA-4fflA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxw ADENOSINE DEAMINASE

(Burkholderia
ambifaria) 		PF00962
(A_deaminase) 		4 TYR A  66
ILE A  62
LEU A  82
LEU A  87
 None
 0.71A 2vctA-4gxwA:
undetectable		 2vctA-4gxwA:
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 TYR A   9
GLY A  14
ARG A  15
LEU A 107
LEU A 108
 LZ6  A 301 (-4.6A)
LZ6  A 301 ( 3.9A)
None
LZ6  A 301 (-4.4A)
None
 0.43A 2vctA-4hj2A:
36.0		 2vctA-4hj2A:
94.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx2 HYPOTHETICAL PROTEIN

(Legionella
pneumophila) 		no annotation 4 ILE A 252
GLY A 253
LEU A 257
LEU A 260
 None
 0.78A 2vctA-4jx2A:
3.2		 2vctA-4jx2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ILE A 260
LEU A 232
LEU A 230
PHE A 268
 None
 0.89A 2vctA-4kt1A:
undetectable		 2vctA-4kt1A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lzk PIXA INCLUSION BODY
PROTEIN

(Burkholderia
cenocepacia) 		PF12306
(PixA) 		4 ILE A  96
GLY A  83
LEU A  20
LEU A  53
 None
 0.86A 2vctA-4lzkA:
undetectable		 2vctA-4lzkA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6f PUTATIVE THIOSUGAR
SYNTHASE

(Amycolatopsis
orientalis) 		PF05690
(ThiG) 		4 ILE A  52
GLY A  82
LEU A 109
LEU A 111
 None
 0.87A 2vctA-4n6fA:
undetectable		 2vctA-4n6fA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9f CULLIN-5

(Homo sapiens) 		no annotation 4 ILE U  69
ARG U 136
LEU U 140
PHE U 100
 None
 0.85A 2vctA-4n9fU:
undetectable		 2vctA-4n9fU:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE

(Bacteroides
fragilis) 		PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 ILE A 322
GLY A 318
ARG A 308
LEU A 305
 None
 0.60A 2vctA-4ogzA:
undetectable		 2vctA-4ogzA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae) 		PF07859
(Abhydrolase_3) 		4 ILE A  49
LEU A 136
PHE A 139
PHE A  64
 None
 0.87A 2vctA-4p9nA:
undetectable		 2vctA-4p9nA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 ILE A 293
LEU A 264
LEU A 262
PHE A 301
 None
 0.83A 2vctA-4qdhA:
undetectable		 2vctA-4qdhA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ILE A3881
GLY A3884
ARG A3877
LEU A3998
 None
 0.87A 2vctA-4rh7A:
undetectable		 2vctA-4rh7A:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Neisseria
meningitidis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ILE A   6
GLY A   8
LEU A 137
PHE A 117
 None
 0.82A 2vctA-4rybA:
undetectable		 2vctA-4rybA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 TYR P 531
ILE P 533
LEU P 479
LEU P 477
 None
 0.84A 2vctA-4s2tP:
undetectable		 2vctA-4s2tP:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		4 ILE A 303
LEU A 274
LEU A 272
PHE A 311
 None
 0.89A 2vctA-4u7lA:
undetectable		 2vctA-4u7lA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwu INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH) 		4 ILE A  94
GLY A 250
LEU A 271
LEU A 300
 None
 0.75A 2vctA-4xwuA:
undetectable		 2vctA-4xwuA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ys4 MEROZOITE SURFACE
PROTEIN P41

(Plasmodium
falciparum) 		PF07422
(s48_45) 		4 ILE A  52
LEU A  87
LEU A  86
PHE A 109
 None
 0.82A 2vctA-4ys4A:
undetectable		 2vctA-4ys4A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		4 ILE A 183
GLY A 184
LEU A 188
LEU A 191
 None
 0.87A 2vctA-4yzzA:
undetectable		 2vctA-4yzzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)

(Agrobacterium
fabrum) 		PF00496
(SBP_bac_5) 		4 ILE A 488
GLY A 329
ARG A 477
PHE A 332
 None
 0.80A 2vctA-4ze8A:
undetectable		 2vctA-4ze8A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 4 ILE A 236
GLY A 235
LEU A 233
PHE A 195
 None
 0.83A 2vctA-5c2vA:
undetectable		 2vctA-5c2vA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cx8 LIPOPROTEIN RAGB

(Porphyromonas
gingivalis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ILE A 106
GLY A 105
LEU A  81
PHE A  84
 None
 0.83A 2vctA-5cx8A:
2.4		 2vctA-5cx8A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyv TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF01047
(MarR) 		4 GLY A  80
ARG A  79
LEU A  81
LEU A 105
 None
 0.88A 2vctA-5cyvA:
undetectable		 2vctA-5cyvA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN

(Thermobaculum
terrenum) 		PF13181
(TPR_8)
PF13844
(Glyco_transf_41) 		4 ILE A 410
GLY A 334
LEU A 362
LEU A 392
 None
 0.88A 2vctA-5djsA:
undetectable		 2vctA-5djsA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 360
GLY A 393
ARG A 394
LEU A 404
 None
 0.64A 2vctA-5e7qA:
2.1		 2vctA-5e7qA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvt PLASMA KALLIKREIN

(Mus musculus) 		no annotation 4 ILE A 181
GLY A 211
LEU A 209
LEU A 123
 None
 0.80A 2vctA-5gvtA:
undetectable		 2vctA-5gvtA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 ILE A 458
GLY A 482
LEU A 506
LEU A 511
PHE A 487
 None
 1.32A 2vctA-5ixqA:
undetectable		 2vctA-5ixqA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1t TORSIN-1A

(Homo sapiens) 		PF06309
(Torsin) 		4 ILE A 155
LEU A 131
PHE A 132
PHE A 138
 None
 0.89A 2vctA-5j1tA:
undetectable		 2vctA-5j1tA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		4 TYR A 462
ILE A 400
ARG A 392
LEU A 535
 None
 0.88A 2vctA-5jxkA:
2.9		 2vctA-5jxkA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ku1 MITOCHONDRIAL RHO
GTPASE 1

(Homo sapiens) 		PF08355
(EF_assoc_1)
PF08356
(EF_assoc_2) 		5 ILE A 192
LEU A 204
LEU A 209
PHE A 212
PHE A 217
 None
 1.33A 2vctA-5ku1A:
undetectable		 2vctA-5ku1A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B

(Cynara
cardunculus) 		no annotation 4 GLY A 316
LEU A 319
PHE A 320
PHE A 362
 None
 0.88A 2vctA-5nfgA:
undetectable		 2vctA-5nfgA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ILE A  94
GLY A 250
LEU A 271
LEU A 300
 None
 0.79A 2vctA-5tc3A:
undetectable		 2vctA-5tc3A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5urb METHIONINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 ILE A 339
LEU A 324
LEU A  23
PHE A  84
 None
 0.85A 2vctA-5urbA:
2.5		 2vctA-5urbA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5va3 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2

(Homo sapiens) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF13426
(PAS_9) 		4 ILE A 571
GLY A 572
LEU A 586
LEU A 589
 None
 0.71A 2vctA-5va3A:
undetectable		 2vctA-5va3A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkv CYTOCHROME C-TYPE
BIOGENESIS PROTEIN
CCDA

(Thermus
thermophilus) 		no annotation 4 ILE A 128
GLY A 129
LEU A 136
PHE A  54
 None
 0.83A 2vctA-5vkvA:
undetectable		 2vctA-5vkvA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1d PROTOCADHERIN-15

(Mus musculus) 		no annotation 4 ILE A 393
GLY A 381
ARG A 477
LEU A 397
 None
 0.79A 2vctA-5w1dA:
undetectable		 2vctA-5w1dA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		no annotation 4 ILE B 101
LEU B  72
LEU B  70
PHE B 109
 None
 0.80A 2vctA-5xwuB:
undetectable		 2vctA-5xwuB:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		no annotation 4 ILE B 149
LEU B 120
LEU B 118
PHE B 157
 None
 0.77A 2vctA-5xwuB:
undetectable		 2vctA-5xwuB:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 4 ILE A 714
LEU A 685
LEU A 683
PHE A 722
 None
 0.85A 2vctA-5zlnA:
undetectable		 2vctA-5zlnA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 4 GLY A  72
ARG A  20
LEU A  96
PHE A  12
 None
 0.70A 2vctA-6a8mA:
undetectable		 2vctA-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus) 		no annotation 4 TYR A 349
ILE A 366
LEU A 157
PHE A 154
 None
 0.82A 2vctA-6d0nA:
undetectable		 2vctA-6d0nA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 4 ILE A 182
GLY A  84
PHE A 116
PHE A 118
 None
 0.64A 2vctA-6ekiA:
undetectable		 2vctA-6ekiA:
16.67