SIMILAR PATTERNS OF AMINO ACIDS FOR 2VAV_F_CSCF1383_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnv GALLERIA MELLONELLA
DENSOVIRUS CAPSID
PROTEIN

(Lepidopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		3 LEU A 358
MET A 159
MET A 219
 None
 0.96A 2vavF-1dnvA:
undetectable		 2vavF-1dnvA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE

(Rattus
norvegicus) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		3 LEU A 247
MET A 251
MET A 299
 None
 0.65A 2vavF-1gjvA:
undetectable		 2vavF-1gjvA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4i AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9) 		3 LEU A  10
MET A  48
MET A  27
 None
 1.00A 2vavF-1m4iA:
undetectable		 2vavF-1m4iA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1m HYPOTHETICAL PROTEIN
TM0936

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		3 LEU A 276
MET A 316
MET A 130
 None
 1.03A 2vavF-1p1mA:
1.8		 2vavF-1p1mA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		3 LEU A 123
MET A 127
MET A 381
 None
 0.99A 2vavF-1s0uA:
3.2		 2vavF-1s0uA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgm PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YXAF

(Bacillus
subtilis) 		PF00440
(TetR_N) 		3 LEU A 155
MET A 159
MET A 125
 None
 0.88A 2vavF-1sgmA:
undetectable		 2vavF-1sgmA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t98 CHROMOSOME PARTITION
PROTEIN MUKF

(Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M) 		3 LEU A 123
MET A 127
MET A 178
 None
 0.77A 2vavF-1t98A:
undetectable		 2vavF-1t98A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 LEU A 209
MET A 149
MET A 107
 None
 0.99A 2vavF-1vbgA:
undetectable		 2vavF-1vbgA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w89 THIOREDOXIN

(Homo sapiens) 		PF00085
(Thioredoxin) 		3 LEU A  78
MET A  80
MET A  44
 None
 0.86A 2vavF-1w89A:
undetectable		 2vavF-1w89A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x87 UROCANASE PROTEIN

(Geobacillus
stearothermophilus) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		3 LEU A 179
MET A 183
MET A 220
 None
 1.04A 2vavF-1x87A:
undetectable		 2vavF-1x87A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc1 UBIQUITIN FUSION
DEGRADATION PROTEIN
1

(Saccharomyces
cerevisiae) 		PF03152
(UFD1) 		3 LEU A  58
MET A  67
MET A  17
 None
 1.06A 2vavF-1zc1A:
undetectable		 2vavF-1zc1A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avt DNA POLYMERASE III
BETA SUBUNIT

(Streptococcus
pyogenes) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 LEU A 371
MET A 185
MET A 275
 None
 1.00A 2vavF-2avtA:
undetectable		 2vavF-2avtA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4e CORONIN-1A

(Mus musculus) 		PF00400
(WD40)
PF08953
(DUF1899)
PF16300
(WD40_4) 		3 LEU A  60
MET A  47
MET A 107
 None
 0.90A 2vavF-2b4eA:
undetectable		 2vavF-2b4eA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f22 BH3987

(Bacillus
halodurans) 		PF05163
(DinB) 		3 LEU A   7
MET A  80
MET A 105
 None
 0.91A 2vavF-2f22A:
undetectable		 2vavF-2f22A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHL

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox) 		3 LEU C 131
MET C 135
MET C 253
 None
 0.98A 2vavF-2inpC:
undetectable		 2vavF-2inpC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 LEU A 156
MET A 160
MET A 199
 None
 0.98A 2vavF-2nlxA:
undetectable		 2vavF-2nlxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE

(Shewanella
oneidensis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 LEU A 207
MET A 209
MET A 284
 None
 0.95A 2vavF-2oasA:
undetectable		 2vavF-2oasA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7t PROTEIN TRAI

(Escherichia
coli) 		PF08751
(TrwC) 		3 LEU A  82
MET A   2
MET A  29
 None
 0.92A 2vavF-2q7tA:
undetectable		 2vavF-2q7tA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 LEU A 620
MET A 618
MET A 720
 None
None
KCX  A 718 ( 3.6A)
 0.88A 2vavF-2qf7A:
undetectable		 2vavF-2qf7A:
17.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vat ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE

(Acremonium
chrysogenum) 		PF00561
(Abhydrolase_1) 		3 LEU A  59
MET A 150
MET A 367
 None
None
COA  A1383 (-3.6A)
 0.14A 2vavF-2vatA:
58.4		 2vavF-2vatA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00854
(PTR2) 		3 LEU A  39
MET A  40
MET A 168
 None
 1.04A 2vavF-2xutA:
undetectable		 2vavF-2xutA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		3 LEU A 440
MET A 445
MET A 366
 None
None
4AG  A1200 (-3.3A)
 0.85A 2vavF-2yevA:
undetectable		 2vavF-2yevA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 LEU A 214
MET A 215
MET A 233
 None
 1.04A 2vavF-2yfkA:
undetectable		 2vavF-2yfkA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		3 LEU A 643
MET A 641
MET A 743
 None
 0.89A 2vavF-3bg9A:
undetectable		 2vavF-3bg9A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00196
(GerE) 		3 LEU A  69
MET A  73
MET A 109
 None
 0.95A 2vavF-3c3wA:
undetectable		 2vavF-3c3wA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cad LECTIN-RELATED NK
CELL RECEPTOR LY49G1

(Mus musculus) 		PF00059
(Lectin_C) 		3 LEU A 240
MET A 233
MET A 155
 None
 1.01A 2vavF-3cadA:
undetectable		 2vavF-3cadA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE

(Bacillus cereus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LEU A 198
MET A 201
MET A  64
 DAL  A 701 ( 4.1A)
None
None
 0.99A 2vavF-3dhvA:
undetectable		 2vavF-3dhvA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU X 214
MET X 154
MET X 138
 None
 0.51A 2vavF-3e3bX:
undetectable		 2vavF-3e3bX:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euh CHROMOSOME PARTITION
PROTEIN MUKF

(Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M)
PF17193
(MukF_C) 		3 LEU A 123
MET A 127
MET A 178
 None
 0.89A 2vavF-3euhA:
undetectable		 2vavF-3euhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fh2 PROBABLE
ATP-DEPENDENT
PROTEASE (HEAT SHOCK
PROTEIN)

(Corynebacterium
glutamicum) 		PF02861
(Clp_N) 		3 LEU A  88
MET A   1
MET A  98
 None
 0.90A 2vavF-3fh2A:
undetectable		 2vavF-3fh2A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 LEU A 643
MET A 641
MET A 743
 None
 0.68A 2vavF-3ho8A:
undetectable		 2vavF-3ho8A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5p NUCLEOPORIN NUP170

(Saccharomyces
cerevisiae) 		PF03177
(Nucleoporin_C) 		3 LEU A1183
MET A1187
MET A1161
 None
 0.87A 2vavF-3i5pA:
undetectable		 2vavF-3i5pA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibr BACTERIOPHYTOCHROME

(Pseudomonas
aeruginosa) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		3 LEU A 151
MET A 154
MET A 279
 None
 1.06A 2vavF-3ibrA:
undetectable		 2vavF-3ibrA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		no annotation 3 LEU K 717
MET K 714
MET K 793
 None
 0.62A 2vavF-3jblK:
undetectable		 2vavF-3jblK:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Streptococcus
pyogenes) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LEU A 196
MET A 199
MET A  62
 None
 1.01A 2vavF-3lgxA:
undetectable		 2vavF-3lgxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		3 LEU A 171
MET A 137
MET A 121
 None
 0.71A 2vavF-3lq1A:
undetectable		 2vavF-3lq1A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		3 LEU B 565
MET B 569
MET B 871
 None
 0.96A 2vavF-3o8oB:
2.4		 2vavF-3o8oB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3og9 PROTEIN YAHD A
COPPER INDUCIBLE
HYDROLASE

(Lactococcus
lactis) 		PF01738
(DLH) 		3 LEU A  17
MET A 101
MET A  35
 None
 1.02A 2vavF-3og9A:
14.3		 2vavF-3og9A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		3 LEU A 200
MET A 247
MET A 171
 None
 0.91A 2vavF-3pdiA:
undetectable		 2vavF-3pdiA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 LEU A 231
MET A 196
MET A 475
 None
 1.06A 2vavF-3pocA:
undetectable		 2vavF-3pocA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		3 LEU B 894
MET B 898
MET B 595
 None
 0.95A 2vavF-3qd2B:
2.7		 2vavF-3qd2B:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhd LACTALDEHYDE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00171
(Aldedh) 		3 LEU A 282
MET A 280
MET A 294
 None
 0.93A 2vavF-3rhdA:
undetectable		 2vavF-3rhdA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro8 ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
sp. JDR-2) 		PF00331
(Glyco_hydro_10) 		3 LEU A  33
MET A  36
MET A  78
 None
 0.94A 2vavF-3ro8A:
undetectable		 2vavF-3ro8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		3 LEU A 559
MET A 561
MET A 500
 None
 0.99A 2vavF-3ue3A:
undetectable		 2vavF-3ue3A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
SUBUNIT B

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		3 LEU D  15
MET D  53
MET D  34
 None
 0.87A 2vavF-3vr5D:
undetectable		 2vavF-3vr5D:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 LEU A 338
MET A 303
MET A 296
 None
 0.80A 2vavF-3zo9A:
1.6		 2vavF-3zo9A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxl HIAXHD3

(Humicola
insolens) 		PF04616
(Glyco_hydro_43) 		3 LEU A 265
MET A 290
MET A 522
 None
 1.05A 2vavF-3zxlA:
undetectable		 2vavF-3zxlA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		3 LEU K 299
MET K 303
MET J 247
 None
 0.81A 2vavF-4cr4K:
undetectable		 2vavF-4cr4K:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1o HISTIDINE
DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		3 LEU A 374
MET A 307
MET A 384
 None
 0.97A 2vavF-4e1oA:
2.2		 2vavF-4e1oA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 479
MET A 636
MET A 517
 None
 0.80A 2vavF-4e3cA:
undetectable		 2vavF-4e3cA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		3 LEU A 315
MET A 339
MET A 277
 None
 1.02A 2vavF-4eygA:
undetectable		 2vavF-4eygA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia cuprina) 		PF00135
(COesterase) 		3 LEU A 353
MET A 413
MET A 425
 None
 0.84A 2vavF-4fnmA:
10.9		 2vavF-4fnmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz7 DIHYDROPYRIMIDINASE

(Tetraodon
nigroviridis) 		PF01979
(Amidohydro_1) 		3 LEU A 297
MET A 293
MET A 202
 None
MHA  A 601 (-4.3A)
None
 1.03A 2vavF-4gz7A:
undetectable		 2vavF-4gz7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 LEU A 115
MET A 113
MET A 225
 None
 0.96A 2vavF-4h1sA:
undetectable		 2vavF-4h1sA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hln STARCH SYNTHASE I

(Hordeum vulgare) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		3 LEU A 497
MET A 499
MET A 445
 None
 1.01A 2vavF-4hlnA:
4.1		 2vavF-4hlnA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzi ABC TRANSPORTER
ATP-BINDING PROTEIN

(Leptospira
interrogans) 		PF00005
(ABC_tran) 		3 LEU A  85
MET A 169
MET A  55
 None
 0.91A 2vavF-4hziA:
undetectable		 2vavF-4hziA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inw PHEROMONE-BINDING
PROTEIN 1

(Amyelois
transitella) 		PF01395
(PBP_GOBP) 		3 LEU A 112
MET A 109
MET A  61
 None
None
1EY  A 201 ( 4.2A)
 1.02A 2vavF-4inwA:
undetectable		 2vavF-4inwA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		3 LEU A 252
MET A 192
MET A 176
 None
 0.68A 2vavF-4jr7A:
undetectable		 2vavF-4jr7A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx6 PYRUVATE CARBOXYLASE

(Rhizobium etli) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		3 LEU A 620
MET A 618
MET A 720
 None
None
KCX  A 718 ( 3.6A)
 0.91A 2vavF-4jx6A:
undetectable		 2vavF-4jx6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpk ENOYL-COA
HYDRATASE/ISOMERASE

(Shewanella
pealeana) 		PF00378
(ECH_1) 		3 LEU A  53
MET A 107
MET A 219
 None
 0.97A 2vavF-4kpkA:
2.6		 2vavF-4kpkA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 SILKWORM STORAGE
PROTEIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 LEU A  72
MET A  85
MET A  64
 None
 1.05A 2vavF-4l37A:
undetectable		 2vavF-4l37A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmx CRYPTOPHYTE
PHYCOERYTHRIN (BETA
CHAIN)

(Hemiselmis
andersenii) 		PF00502
(Phycobilisome) 		3 LEU B  98
MET B  38
MET B 134
 None
PEB  B 202 (-4.7A)
None
 1.06A 2vavF-4lmxB:
undetectable		 2vavF-4lmxB:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 LEU A 346
MET A 311
MET A 304
 GOL  A 704 ( 4.6A)
None
None
 0.67A 2vavF-4lxfA:
undetectable		 2vavF-4lxfA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU E 213
MET E 153
MET E 137
 None
 0.66A 2vavF-4md8E:
undetectable		 2vavF-4md8E:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		3 LEU A 179
MET A   1
MET A 188
 None
 0.96A 2vavF-4o6rA:
undetectable		 2vavF-4o6rA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdr NEUROPILIN-2

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		3 LEU A 587
MET A 440
MET A 338
 None
 1.03A 2vavF-4qdrA:
undetectable		 2vavF-4qdrA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 3 LEU H 612
MET H 610
MET H 712
 None
 0.78A 2vavF-4qslH:
undetectable		 2vavF-4qslH:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rul DNA TOPOISOMERASE 1

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01396
(zf-C4_Topoisom)
PF01751
(Toprim)
PF08272
(Topo_Zn_Ribbon) 		3 LEU A 594
MET A 592
MET A 669
 None
 0.90A 2vavF-4rulA:
undetectable		 2vavF-4rulA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		3 LEU A 407
MET A 408
MET A 576
 None
 0.99A 2vavF-4xhjA:
undetectable		 2vavF-4xhjA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhg GH5

(Bacteroidetes
bacterium AC2a) 		PF00150
(Cellulase) 		3 LEU A  95
MET A  98
MET A  22
 None
 0.98A 2vavF-4yhgA:
undetectable		 2vavF-4yhgA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywj 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Pseudomonas
aeruginosa) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		3 LEU A  73
MET A  96
MET A   1
 None
 0.80A 2vavF-4ywjA:
4.0		 2vavF-4ywjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		3 LEU A 119
MET A 120
MET A 108
 None
 1.04A 2vavF-5abmA:
undetectable		 2vavF-5abmA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00632
(HECT) 		3 LEU A 773
MET A 777
MET A 835
 None
 0.95A 2vavF-5c91A:
undetectable		 2vavF-5c91A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbu PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N) 		3 LEU A 366
MET A 359
MET A 750
 None
 0.92A 2vavF-5fbuA:
undetectable		 2vavF-5fbuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus musculus) 		PF05175
(MTS) 		3 LEU A 386
MET A 388
MET A 417
 None
 1.06A 2vavF-5fulA:
undetectable		 2vavF-5fulA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 3 LEU A 325
MET A 290
MET A 283
 None
 0.81A 2vavF-5h2tA:
undetectable		 2vavF-5h2tA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h60 TRANSFERASE

(Escherichia
coli) 		no annotation 3 LEU A 273
MET A 193
MET A 254
 None
 1.06A 2vavF-5h60A:
undetectable		 2vavF-5h60A:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		3 LEU A2354
MET A2345
MET A2387
 None
 1.03A 2vavF-5h64A:
undetectable		 2vavF-5h64A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 FIG000906: PREDICTED
PERMEASE

(Klebsiella
pneumoniae) 		PF03739
(YjgP_YjgQ) 		3 LEU G  78
MET G  82
MET G 107
 None
PT  G 401 ( 4.9A)
None
 1.03A 2vavF-5l75G:
undetectable		 2vavF-5l75G:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 FIG000988: PREDICTED
PERMEASE

(Klebsiella
pneumoniae) 		PF03739
(YjgP_YjgQ) 		3 LEU F  70
MET F  74
MET F 103
 None
 1.00A 2vavF-5l75F:
undetectable		 2vavF-5l75F:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF06444
(NADH_dehy_S2_C) 		3 LEU N 153
MET N  96
MET N 139
 None
 0.76A 2vavF-5lc5N:
undetectable		 2vavF-5lc5N:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5x DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA135

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF06883
(RNA_pol_Rpa2_4) 		3 LEU B 404
MET B 205
MET B 461
 None
 0.72A 2vavF-5m5xB:
undetectable		 2vavF-5m5xB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mms CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		3 LEU A 106
MET A  89
MET A 337
 None
 1.04A 2vavF-5mmsA:
undetectable		 2vavF-5mmsA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 213
MET A 153
MET A 137
 None
 0.71A 2vavF-5movA:
undetectable		 2vavF-5movA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		3 LEU A1399
MET A1403
MET A1329
 None
 0.87A 2vavF-5mzoA:
undetectable		 2vavF-5mzoA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 3 LEU A 887
MET A 891
MET A 842
 None
 0.99A 2vavF-5n2gA:
undetectable		 2vavF-5n2gA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN

(Sinorhizobium
meliloti) 		PF12833
(HTH_18)
PF14525
(AraC_binding_2) 		3 LEU A 171
MET A 173
MET A  67
 None
 0.56A 2vavF-5nlaA:
undetectable		 2vavF-5nlaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oet GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 30
(GPA-GSS30-APO)

(Globodera
pallida) 		no annotation 3 LEU B 113
MET B 373
MET B 351
 None
 1.05A 2vavF-5oetB:
undetectable		 2vavF-5oetB:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR BETA
RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 3 LEU A 392
MET A 230
MET B 366
 None
 1.03A 2vavF-5uanA:
undetectable		 2vavF-5uanA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 3 LEU A  33
MET A 406
MET A 211
 None
 1.06A 2vavF-5vm9A:
2.6		 2vavF-5vm9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1u UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 3 LEU A 285
MET A 319
MET A 230
 None
 1.03A 2vavF-5x1uA:
undetectable		 2vavF-5x1uA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd7 3,6-ANHYDRO-ALPHA-L-
GALACTONATE
CYCLOISOMERASE

(Vibrio sp. EJY3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 252
MET A 248
MET A 302
 None
 0.94A 2vavF-5xd7A:
undetectable		 2vavF-5xd7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN SA

(Trichomonas
vaginalis) 		PF00318
(Ribosomal_S2) 		3 LEU A 145
MET A 169
MET A  15
 None
 1.05A 2vavF-5xyiA:
undetectable		 2vavF-5xyiA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 3 LEU A 688
MET A 692
MET A 665
 None
 1.03A 2vavF-6a91A:
2.1		 2vavF-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsp MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
9) 		no annotation 3 LEU C 246
MET C 237
MET C 394
 None
 0.98A 2vavF-6bspC:
undetectable		 2vavF-6bspC:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 3 LEU A 440
MET A 310
MET A 191
 None
 1.01A 2vavF-6c4gA:
undetectable		 2vavF-6c4gA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 3 LEU D 227
MET D 230
MET D 636
 None
 1.04A 2vavF-6eq8D:
undetectable		 2vavF-6eq8D:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es4 SYNCRIP, ISOFORM K

(Drosophila
melanogaster) 		no annotation 3 LEU A  96
MET A 100
MET A 197
 None
 0.87A 2vavF-6es4A:
undetectable		 2vavF-6es4A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exc ICMP (DOTM)

(Legionella
pneumophila) 		no annotation 3 LEU A 285
MET A 319
MET A 230
 None
 0.99A 2vavF-6excA:
undetectable		 2vavF-6excA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 3 LEU A 137
MET A 931
MET A 877
 None
 0.95A 2vavF-6fn1A:
undetectable		 2vavF-6fn1A:
10.86