SIMILAR PATTERNS OF AMINO ACIDS FOR 2V95_A_HCYA1375

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		5 PRO A  36
VAL A   9
ILE A  45
ASP A  43
PHE A  67
 None
 1.15A 2v95A-1a2oA:
undetectable		 2v95A-1a2oA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1) 		PF00082
(Peptidase_S8) 		6 ALA A 205
PRO A 206
VAL A 185
ILE A 260
ASP A 258
PHE A 267
 None
 1.22A 2v95A-1dbiA:
0.0		 2v95A-1dbiA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6o CAG-ALPHA

(Helicobacter
pylori) 		PF00437
(T2SSE) 		5 VAL A  56
THR A  32
PHE A  84
ILE A 130
PHE A  36
 None
 0.98A 2v95A-1g6oA:
0.3		 2v95A-1g6oA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7e ENDOPLASMIC
RETICULUM PROTEIN
ERP29

(Rattus
norvegicus) 		PF07912
(ERp29_N) 		5 ALA A  89
VAL A  58
PHE A 126
ILE A  50
PHE A  46
 None
 1.31A 2v95A-1g7eA:
undetectable		 2v95A-1g7eA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ism BONE MARROW STROMAL
CELL ANTIGEN 1

(Homo sapiens) 		PF02267
(Rib_hydrolayse) 		5 ALA A  20
ARG A  23
ILE A  38
ASP A  34
PHE A  15
 None
 1.25A 2v95A-1ismA:
0.0		 2v95A-1ismA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhw MACROPHAGE CAPPING
PROTEIN

(Homo sapiens) 		PF00626
(Gelsolin) 		5 ALA A 266
VAL A 265
GLN A 332
ILE A 277
PHE A 282
 None
 1.20A 2v95A-1jhwA:
0.0		 2v95A-1jhwA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkh MEVALONATE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ALA A 127
VAL A 128
THR A  44
ILE A  49
PHE A 100
 None
 1.27A 2v95A-1kkhA:
0.0		 2v95A-1kkhA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llu ALCOHOL
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 132
PRO A 134
VAL A 137
PHE A 146
ASP A  87
 None
 1.34A 2v95A-1lluA:
0.0		 2v95A-1lluA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llu ALCOHOL
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 132
PRO A 134
VAL A 137
PHE A 146
LYS A  37
 None
 1.22A 2v95A-1lluA:
0.0		 2v95A-1lluA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2b [2FE-2S] FERREDOXIN

(Aquifex
aeolicus) 		no annotation 5 PRO A  63
VAL A  65
ILE A  85
ASP A  81
PHE A  34
 None
 1.20A 2v95A-1m2bA:
undetectable		 2v95A-1m2bA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfh PROTEIN (GELATION
FACTOR)

(Dictyostelium
discoideum) 		PF00630
(Filamin) 		5 ALA A 767
VAL A 765
THR A 855
PHE A 782
LYS A 781
 None
 1.08A 2v95A-1qfhA:
undetectable		 2v95A-1qfhA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 ALA X 142
VAL X  83
ILE X 131
PHE X  77
LYS X 137
 None
 1.17A 2v95A-1u8xX:
undetectable		 2v95A-1u8xX:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlh GELATION FACTOR

(Dictyostelium
discoideum) 		PF00630
(Filamin) 		5 ALA A 767
VAL A 765
THR A 855
PHE A 782
LYS A 781
 None
 1.13A 2v95A-1wlhA:
undetectable		 2v95A-1wlhA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ALA A  38
PHE A 111
ILE A  86
ASP A  85
PHE A  88
 None
 1.33A 2v95A-1ys4A:
undetectable		 2v95A-1ys4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 VAL A 350
ILE A  86
ASP A  85
PHE A  34
LYS A   8
 None
 1.11A 2v95A-1ys4A:
undetectable		 2v95A-1ys4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE

(Streptomyces
cattleya) 		PF01887
(SAM_adeno_trans) 		5 ALA A 121
PRO A 122
VAL A 162
ASP A  16
PHE A  13
 None
None
None
SA8  A1299 (-2.9A)
None
 1.30A 2v95A-2c4tA:
undetectable		 2v95A-2c4tA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d16 HYPOTHETICAL PROTEIN
PH1918

(Pyrococcus
horikoshii) 		PF04008
(Adenosine_kin) 		5 ALA A 104
PRO A 103
VAL A 105
ILE A  99
PHE A  83
 None
 1.12A 2v95A-2d16A:
undetectable		 2v95A-2d16A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6l LECTIN, GALACTOSE
BINDING, SOLUBLE 9

(Mus musculus) 		PF00337
(Gal-bind_lectin) 		5 PRO X  16
VAL X 135
GLN X   7
PHE X 146
ILE X 144
 None
 1.32A 2v95A-2d6lX:
undetectable		 2v95A-2d6lX:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmd LECTIN

(Leucomphalos
mildbraedii) 		PF00139
(Lectin_legB) 		5 ALA A  67
THR A  71
PHE A  90
ILE A  92
PHE A  69
 None
 1.22A 2v95A-2fmdA:
undetectable		 2v95A-2fmdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A  68
PRO A 101
VAL A 102
PHE A  58
ASP A  98
 None
 1.35A 2v95A-2ihtA:
undetectable		 2v95A-2ihtA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)

(Homo sapiens) 		no annotation 5 ALA A 261
THR A 307
PHE A 296
ILE A 294
PHE A 308
 None
 1.19A 2v95A-2jdxA:
undetectable		 2v95A-2jdxA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jrb ORF 1 PROTEIN

(Mus musculus) 		PF17490
(Tnp_22_dsRBD) 		5 ALA A 299
VAL A 303
ILE A 324
PHE A 339
LYS A 338
 None
 1.19A 2v95A-2jrbA:
undetectable		 2v95A-2jrbA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
RIBONUCLEASE P
PROTEIN COMPONENT 4

(Pyrococcus
furiosus) 		PF01868
(UPF0086)
PF04032
(Rpr2) 		5 ALA B  25
VAL B  28
ILE A  71
ASP A  72
PHE A  30
 None
 1.15A 2v95A-2ki7B:
undetectable		 2v95A-2ki7B:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l5l THIOREDOXIN

(Bacteroides
vulgatus) 		PF00085
(Thioredoxin) 		5 PRO A  52
VAL A  56
PHE A  98
ILE A  96
PHE A 117
 None
 1.33A 2v95A-2l5lA:
undetectable		 2v95A-2l5lA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz1 SMALL INDUCIBLE
CYTOKINE A2

(Homo sapiens) 		PF00048
(IL8) 		5 ALA D  53
VAL D  41
ILE D  64
LYS D  58
TRP D  59
 None
 1.25A 2v95A-2nz1D:
undetectable		 2v95A-2nz1D:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5z TYPE VI SECRETION
SYSTEM COMPONENT

(Escherichia
coli) 		PF05954
(Phage_GPD) 		5 PRO X 364
VAL X 341
GLN X 314
THR X 359
PHE X 360
 None
 1.23A 2v95A-2p5zX:
undetectable		 2v95A-2p5zX:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6t DNAB REPLICATION
FORK HELICASE

(Thermus
aquaticus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 ALA A 207
THR A 219
PHE A 187
ILE A 413
PHE A 216
 None
 1.17A 2v95A-2q6tA:
undetectable		 2v95A-2q6tA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9g CYTOCHROME P450 46A1

(Homo sapiens) 		PF00067
(p450) 		5 THR A 298
PHE A 299
ILE A 141
ASP A 142
TRP A 134
 None
HEM  A 505 (-4.0A)
None
None
HEM  A 505 (-3.7A)
 1.19A 2v95A-2q9gA:
undetectable		 2v95A-2q9gA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis) 		no annotation 5 PRO A 324
VAL A 326
THR A 379
ILE A 360
ASP A 359
 NO3  A 502 (-3.7A)
None
None
None
None
 1.34A 2v95A-2q9uA:
undetectable		 2v95A-2q9uA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 5 ALA A 188
VAL A 187
THR A 176
PHE A 140
ILE A 138
 None
 1.15A 2v95A-2quaA:
undetectable		 2v95A-2quaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 ALA A 730
THR A 654
ILE A 724
ASP A 723
PHE A 697
 None
 1.31A 2v95A-2vcaA:
undetectable		 2v95A-2vcaA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3das PUTATIVE
OXIDOREDUCTASE

(Streptomyces
coelicolor) 		PF07995
(GSDH) 		5 ALA A 269
PRO A 315
VAL A 313
GLN A 300
PHE A 302
 None
None
None
EDO  A4334 (-4.3A)
EDO  A4334 ( 4.2A)
 1.21A 2v95A-3dasA:
undetectable		 2v95A-3dasA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwi CYSTEINE SYNTHASE B

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 VAL A 292
GLN A 151
THR A 185
ILE A  50
ASP A 295
 None
None
PLP  A 401 (-3.2A)
None
PLP  A 401 (-3.2A)
 1.22A 2v95A-3dwiA:
undetectable		 2v95A-3dwiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f67 PUTATIVE
DIENELACTONE
HYDROLASE

(Klebsiella
pneumoniae) 		PF01738
(DLH) 		5 ALA A  20
THR A 117
PHE A 119
ILE A  45
ASP A  47
 None
 1.08A 2v95A-3f67A:
undetectable		 2v95A-3f67A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9r PHOSPHOMANNOMUTASE

(Trypanosoma
brucei) 		PF03332
(PMM) 		5 VAL A 239
THR A  42
PHE A  63
ILE A  30
PHE A   9
 None
 1.18A 2v95A-3f9rA:
undetectable		 2v95A-3f9rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyq RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE

(Streptomyces
cyaneus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		5 ALA A  14
PRO A  13
PHE A  97
ILE A  19
ASP A  20
 None
 1.29A 2v95A-3gyqA:
undetectable		 2v95A-3gyqA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 ALA B 506
PRO B 507
VAL B 600
PHE B 483
ILE B 590
 None
 1.29A 2v95A-3hhsB:
undetectable		 2v95A-3hhsB:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ht4 ALUMINUM RESISTANCE
PROTEIN

(Bacillus cereus) 		PF06838
(Met_gamma_lyase) 		5 ALA A 344
PHE A 303
ILE A 411
ASP A 412
LYS A 404
 None
 1.07A 2v95A-3ht4A:
undetectable		 2v95A-3ht4A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyv SULFIDE-QUINONE
REDUCTASE

(Aquifex
aeolicus) 		PF07992
(Pyr_redox_2) 		5 ALA A 245
PRO A 244
VAL A 231
ILE A 185
PHE A 250
 None
 1.29A 2v95A-3hyvA:
undetectable		 2v95A-3hyvA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4q APC40078

(Oleispira
antarctica) 		PF00719
(Pyrophosphatase) 		5 ALA A 108
PRO A  90
VAL A 109
GLN A 129
ASP A 123
 None
 1.29A 2v95A-3i4qA:
undetectable		 2v95A-3i4qA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibt 1H-3-HYDROXY-4-OXOQU
INOLINE
2,4-DIOXYGENASE

(Pseudomonas
putida) 		PF12697
(Abhydrolase_6) 		5 THR A  23
PHE A  25
ILE A  81
ASP A  82
PHE A  89
 None
 1.32A 2v95A-3ibtA:
undetectable		 2v95A-3ibtA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irz URO-ADHERENCE FACTOR
A

(Staphylococcus
saprophyticus) 		PF17210
(SdrD_B) 		5 PRO A 549
VAL A 550
THR A 634
ARG A 679
LYS A 579
 None
 0.96A 2v95A-3irzA:
undetectable		 2v95A-3irzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mw4 NEUREXIN-2-BETA

(Mus musculus) 		PF02210
(Laminin_G_2) 		5 ALA A 130
PRO A 131
THR A 106
ILE A 127
PHE A 205
 None
 1.11A 2v95A-3mw4A:
undetectable		 2v95A-3mw4A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n79 PDUT

(Salmonella
enterica) 		PF00936
(BMC) 		5 ALA A  84
PRO A  83
THR A 102
ILE A 109
ASP A 113
 None
 1.31A 2v95A-3n79A:
undetectable		 2v95A-3n79A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onk EPSIN-3

(Saccharomyces
cerevisiae) 		PF01417
(ENTH) 		5 ALA A 160
THR A  59
PHE A 105
ILE A  98
ASP A  95
 None
 1.25A 2v95A-3onkA:
undetectable		 2v95A-3onkA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2m POSSIBLE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		5 ALA A 167
PRO A 168
VAL A 171
ILE A 161
ASP A 264
 None
 1.30A 2v95A-3p2mA:
undetectable		 2v95A-3p2mA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qzy BACULOVIRUS
SULFHYDRYL OXIDASE
AC92

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF05214
(Baculo_p33) 		5 PRO A   3
THR A 112
ILE A 119
ASP A 121
PHE A 115
 None
None
None
None
IMD  A 261 (-4.5A)
 1.29A 2v95A-3qzyA:
undetectable		 2v95A-3qzyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 ALA N  48
PRO N  13
VAL N  17
THR N  87
PHE N 241
 None
 1.29A 2v95A-3rkoN:
undetectable		 2v95A-3rkoN:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry7 RIBOKINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 ALA A 147
PRO A 121
VAL A 124
THR A 162
ILE A 154
 None
 1.23A 2v95A-3ry7A:
undetectable		 2v95A-3ry7A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry7 RIBOKINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 GLN A 235
THR A 232
PHE A 230
ILE A 275
ASP A 273
 None
 1.28A 2v95A-3ry7A:
undetectable		 2v95A-3ry7A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6v AC-ASP-7

(Ancylostoma
caninum) 		no annotation 5 VAL A  14
THR A  78
ARG A  19
ILE A  22
ASP A  23
 None
 0.99A 2v95A-3s6vA:
undetectable		 2v95A-3s6vA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ud2 ANKYRIN-1

(Homo sapiens) 		no annotation 5 ALA C 945
PRO C 946
THR C1057
ILE C 938
PHE C 985
 None
 1.30A 2v95A-3ud2C:
undetectable		 2v95A-3ud2C:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN

(Streptomyces
thermoviolaceus) 		PF01547
(SBP_bac_1) 		5 ALA A 238
PRO A 237
VAL A 239
THR A 396
ILE A 226
 None
 1.00A 2v95A-3vxcA:
undetectable		 2v95A-3vxcA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 VAL A 799
GLN A 733
ILE A 746
ASP A 745
PHE A 804
 None
 1.34A 2v95A-3w9hA:
undetectable		 2v95A-3w9hA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyh LYSOZYME G

(Struthio
camelus) 		PF01464
(SLT) 		5 ALA A  64
PRO A  63
VAL A  65
THR A  13
ASP A   7
 None
 1.30A 2v95A-3wyhA:
undetectable		 2v95A-3wyhA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zc7 ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VBHT

(Bartonella
schoenbuchensis) 		PF02661
(Fic) 		5 ALA A 100
PRO A 101
THR A 145
ASP A  58
PHE A 149
 None
 1.17A 2v95A-3zc7A:
undetectable		 2v95A-3zc7A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zcb ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VBHT

(Bartonella
schoenbuchensis) 		PF02661
(Fic) 		5 ALA A 100
PRO A 101
THR A 145
ASP A  58
PHE A 149
 None
 1.11A 2v95A-3zcbA:
undetectable		 2v95A-3zcbA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zei O-ACETYLSERINE
SULFHYDRYLASE

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 ALA A 270
VAL A 291
GLN A 144
THR A 179
ASP A 294
 None
None
AWH  A1302 (-3.3A)
PLP  A1301 (-2.8A)
PLP  A1301 (-3.3A)
 1.21A 2v95A-3zeiA:
undetectable		 2v95A-3zeiA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4y PROTEIN MXIG

(Shigella
flexneri) 		PF09480
(PrgH) 		5 PRO A  57
VAL A  58
PHE A  96
ILE A  67
PHE A 103
 None
 1.30A 2v95A-4a4yA:
undetectable		 2v95A-4a4yA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac3 BIFUNCTIONAL PROTEIN
GLMU

(Streptococcus
pneumoniae) 		PF00132
(Hexapep)
PF00483
(NTP_transferase)
PF14602
(Hexapep_2) 		5 ALA A 410
PRO A 411
THR A 364
PHE A 377
ILE A 396
 None
 1.25A 2v95A-4ac3A:
undetectable		 2v95A-4ac3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aej COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		PF01410
(COLFI) 		5 ALA A  84
VAL A 239
PHE A 235
ILE A 223
ASP A 222
 None
 1.30A 2v95A-4aejA:
undetectable		 2v95A-4aejA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b16 CHITINASE LIKE
LECTIN

(Tamarindus
indica) 		PF00704
(Glyco_hydro_18) 		5 ALA A 172
VAL A 142
THR A  45
ILE A 125
ASP A 126
 None
 1.01A 2v95A-4b16A:
undetectable		 2v95A-4b16A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b52 BACILLOLYSIN

(Paenibacillus
polymyxa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 ALA A  79
THR A 260
PHE A 161
ILE A 165
ASP A 168
 None
 1.34A 2v95A-4b52A:
undetectable		 2v95A-4b52A:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		8 ALA A  18
VAL A  22
GLN A 232
THR A 240
PHE A 242
ARG A 260
ILE A 263
PHE A 366
 None
 1.04A 2v95A-4c41A:
39.4		 2v95A-4c41A:
61.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce7 UNSATURATED
3S-RHAMNOGLYCURONYL
HYDROLASE

(Nonlabens
ulvanivorans) 		PF07470
(Glyco_hydro_88) 		5 ALA A 307
PRO A 306
VAL A 308
ILE A 300
ASP A 301
 None
 1.07A 2v95A-4ce7A:
undetectable		 2v95A-4ce7A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY

(Bacillus
subtilis) 		PF00171
(Aldedh) 		5 ALA A 353
VAL A 367
ILE A 293
PHE A 307
LYS A 306
 None
 0.93A 2v95A-4dngA:
undetectable		 2v95A-4dngA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz2 GLUTATHIONE
S-TRANSFERASE DOMAIN

(Xanthobacter
autotrophicus) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 ALA A 180
PRO A 179
VAL A 181
PHE A  96
ASP A 137
 None
 1.24A 2v95A-4hz2A:
undetectable		 2v95A-4hz2A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jj3 MAMP

(Magnetococcus
marinus) 		PF13180
(PDZ_2) 		5 ALA A  84
PRO A  85
VAL A  87
THR A 221
LYS A  80
 None
 1.33A 2v95A-4jj3A:
undetectable		 2v95A-4jj3A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k4k PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
uniformis) 		PF13149
(Mfa_like_1) 		5 ALA A 179
GLN A 249
PHE A 251
ILE A 276
ASP A 172
 None
 1.12A 2v95A-4k4kA:
undetectable		 2v95A-4k4kA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6e E3 SUMO-PROTEIN
LIGASE RANBP2

(Homo sapiens) 		PF00638
(Ran_BP1) 		5 ALA A2938
VAL A3022
THR A3036
ILE A2971
PHE A3033
 None
 1.10A 2v95A-4l6eA:
undetectable		 2v95A-4l6eA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8j PUTATIVE EFFLUX
TRANSPORTER

(Bacteroides
eggerthii) 		PF16576
(HlyD_D23) 		6 PRO A 257
VAL A  51
THR A 218
PHE A 220
ILE A 243
PHE A 212
 None
 1.34A 2v95A-4l8jA:
undetectable		 2v95A-4l8jA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Homo sapiens) 		PF00899
(ThiF)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 VAL A 248
THR A 274
ILE A 277
ASP A  51
PHE A 275
 None
 1.27A 2v95A-4p22A:
undetectable		 2v95A-4p22A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN

(Lactococcus
phage 1358) 		no annotation 5 ALA A 321
THR A 348
PHE A 346
ILE A 261
PHE A 282
 None
 1.28A 2v95A-4rggA:
undetectable		 2v95A-4rggA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 254
GLN A 208
THR A 189
PHE A 210
ILE A 249
 None
 1.34A 2v95A-4uekA:
undetectable		 2v95A-4uekA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uom FAB FRAGMENT HEAVY
CHAIN
FAB FRAGMENT LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL L  59
THR H 101
ARG L  55
ILE L  49
ASP L  53
 None
 1.31A 2v95A-4uomL:
undetectable		 2v95A-4uomL:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v36 LYSYL-TRNA-DEPENDENT
L-YSYL-PHOSPHATIDYLG
YCEROL SYNTHASE

(Bacillus
licheniformis) 		PF09924
(DUF2156) 		5 PRO A 729
PHE A 756
ILE A 738
ASP A 739
PHE A 771
 None
None
None
LYN  A1851 (-4.0A)
None
 1.18A 2v95A-4v36A:
undetectable		 2v95A-4v36A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila) 		no annotation 5 ALA A 785
VAL A 788
ILE A 799
PHE A 776
LYS A 778
 None
 1.14A 2v95A-4zuzA:
undetectable		 2v95A-4zuzA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum) 		no annotation 5 ALA A 567
VAL A 563
THR A 585
ILE A 528
PHE A 582
 None
 1.09A 2v95A-5affA:
undetectable		 2v95A-5affA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		5 ALA A 263
THR A 254
ILE A 272
ASP A 268
PHE A 257
 None
 1.27A 2v95A-5cerA:
undetectable		 2v95A-5cerA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxw PENICILLIN-BINDING
PROTEIN 1A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		5 ALA A 554
VAL A 569
THR A 565
ILE A 595
ASP A 594
 None
 1.17A 2v95A-5cxwA:
undetectable		 2v95A-5cxwA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 ALA A 752
PHE A 804
ILE A 746
ASP A 745
PHE A 801
 None
 1.09A 2v95A-5enoA:
undetectable		 2v95A-5enoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqj TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6

(Saccharomyces
cerevisiae) 		PF04189
(Gcd10p) 		5 PRO A  29
VAL A  43
PHE A  51
ILE A   7
ASP A   8
 None
 1.28A 2v95A-5eqjA:
undetectable		 2v95A-5eqjA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 VAL A 230
PHE A 146
ILE A 141
ASP A 140
PHE A 165
 None
 1.28A 2v95A-5f7sA:
undetectable		 2v95A-5f7sA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fw4 DYE-DECOLORIZING
PEROXIDASE TFU_3078

(Thermobifida
fusca) 		PF04261
(Dyp_perox) 		5 ALA A 377
PRO A 376
GLN A 210
PHE A 215
ILE A 219
 None
 1.28A 2v95A-5fw4A:
undetectable		 2v95A-5fw4A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		5 PRO A1116
VAL A1119
GLN A1183
ARG A1154
ILE A1155
 None
 1.11A 2v95A-5h64A:
undetectable		 2v95A-5h64A:
9.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hgc SERPIN

(Taeniopygia
guttata) 		PF00079
(Serpin) 		5 PRO A  33
THR A 254
PHE A 256
ILE A 277
PHE A 380
 HCY  A 501 (-3.8A)
HCY  A 501 ( 4.1A)
HCY  A 501 (-4.8A)
HCY  A 501 ( 4.2A)
HCY  A 501 (-4.2A)
 0.54A 2v95A-5hgcA:
43.9		 2v95A-5hgcA:
39.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy2 BETA-LACTAMASE
OXA-143

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		5 VAL A 152
THR A 197
ILE A  90
PHE A 193
LYS A 194
 None
 1.32A 2v95A-5iy2A:
undetectable		 2v95A-5iy2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		5 ALA A 121
PRO A 122
VAL A 162
ASP A  16
PHE A  13
 None
 1.25A 2v95A-5lmzA:
undetectable		 2v95A-5lmzA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		5 ALA A 418
VAL A 313
GLN A 308
PHE A 306
LYS A 414
 None
None
MLY  A 413 ( 3.5A)
None
MLY  A 413 ( 3.1A)
 1.27A 2v95A-5thmA:
undetectable		 2v95A-5thmA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqi PYRIDOXAL KINASE
PDXY

(Burkholderia
multivorans) 		PF08543
(Phos_pyr_kin) 		5 ALA A 254
VAL A 251
PHE A  23
ILE A 272
ASP A 270
 None
 1.34A 2v95A-5tqiA:
undetectable		 2v95A-5tqiA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bifidobacterium
bifidum) 		PF11308
(Glyco_hydro_129) 		5 ALA A 152
VAL A 153
GLN A 171
THR A 130
ASP A 192
 None
 0.93A 2v95A-5wzrA:
undetectable		 2v95A-5wzrA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xag TUBULIN TYROSINE
LIGASE

(Gallus gallus) 		no annotation 5 ALA F 339
PHE F 267
ARG F 202
ILE F 201
ASP F 200
 None
None
None
None
MG  F 401 (-3.8A)
 1.29A 2v95A-5xagF:
undetectable		 2v95A-5xagF:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xkl ESX-3
SECRETION-ASSOCIATED
PROTEIN ESPG3

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A 106
ILE A  74
ASP A  72
PHE A 133
LYS A   6
 None
 1.26A 2v95A-5xklA:
undetectable		 2v95A-5xklA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xkl ESX-3
SECRETION-ASSOCIATED
PROTEIN ESPG3

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A 106
VAL A  77
ASP A  72
PHE A 133
LYS A   6
 None
 1.30A 2v95A-5xklA:
undetectable		 2v95A-5xklA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y5a KLLA0F20702P

(Kluyveromyces
lactis) 		no annotation 5 ALA A  79
THR A  12
PHE A  16
ILE A  46
PHE A  13
 None
 1.33A 2v95A-5y5aA:
undetectable		 2v95A-5y5aA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 5 PRO A 538
GLN A 488
THR A 493
ILE A 475
ASP A 510
 None
 1.06A 2v95A-5ykbA:
undetectable		 2v95A-5ykbA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 5 ALA A 397
GLN A 483
THR A 473
ILE A 515
ASP A 513
 None
 1.33A 2v95A-5zl9A:
undetectable		 2v95A-5zl9A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 5 PRO A 837
GLN A 770
PHE A1005
ARG A 839
ILE A 843
 None
 1.16A 2v95A-6bf6A:
undetectable		 2v95A-6bf6A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A 293
GLN A 157
THR A 197
ILE A  52
ASP A 319
 None
ACT  A 402 (-3.0A)
PLP  A 401 (-2.9A)
None
PLP  A 401 (-3.3A)
 1.05A 2v95A-6c2hA:
undetectable		 2v95A-6c2hA:
12.97