SIMILAR PATTERNS OF AMINO ACIDS FOR 2V7U_B_SAMB1300_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu8 HYPOTHETICAL PROTEIN
PH0463


(Pyrococcus
horikoshii)
PF01887
(SAM_adeno_trans)
6 ASP A 179
PHE A 181
ASN A 183
SER A 226
ALA A 233
ASN A 235
None
1.09A 2v7uC-1wu8A:
26.8
2v7uC-1wu8A:
28.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE


(Streptomyces
cattleya)
PF01887
(SAM_adeno_trans)
9 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ARG A 270
ALA A 276
ASN A 278
None
0.20A 2v7uC-2c4tA:
46.9
2v7uC-2c4tA:
99.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG


(Thermus
thermophilus)
PF01887
(SAM_adeno_trans)
6 ASP A 182
PHE A 184
ASN A 186
SER A 227
ALA A 234
ASN A 236
None
0.91A 2v7uC-2cw5A:
23.2
2v7uC-2cw5A:
29.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q6k CHLORINASE

(Salinispora
tropica)
PF01887
(SAM_adeno_trans)
7 ASP A 183
PHE A 186
ASN A 188
TRP A 190
PHE A 228
SER A 242
ASN A 251
PEG  A 402 (-2.9A)
None
None
None
None
PEG  A 402 (-3.3A)
None
0.77A 2v7uC-2q6kA:
31.5
2v7uC-2q6kA:
38.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbv UNCHARACTERIZED
CONSERVED PROTEIN


(Thermotoga
maritima)
PF01887
(SAM_adeno_trans)
7 ASP A 178
PHE A 180
ASN A 182
PHE A 220
SER A 234
ALA A 241
ASN A 243
None
0.86A 2v7uC-2zbvA:
30.6
2v7uC-2zbvA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzh PUTATIVE
UNCHARACTERIZED
PROTEIN


(Streptococcus
pyogenes)
PF09704
(Cas_Cas5d)
5 PHE A 101
ASN A  55
PHE A  99
SER A 126
ARG A 132
None
1.14A 2v7uC-3vzhA:
0.0
2v7uC-3vzhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0j UNCHARACTERIZED
PROTEIN


(Streptococcus
mutans)
PF09704
(Cas_Cas5d)
5 PHE A 103
ASN A  57
PHE A 101
SER A 128
ARG A 134
None
None
None
SO4  A 303 ( 4.7A)
SO4  A 303 (-4.1A)
1.20A 2v7uC-4r0jA:
0.0
2v7uC-4r0jA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmz FLUORINASE

(Streptomyces
sp. MA37)
PF01887
(SAM_adeno_trans)
8 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ALA A 276
ASN A 278
None
1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
None
1DA  A 301 (-3.3A)
None
1DA  A 301 (-3.0A)
1DA  A 301 ( 4.4A)
0.35A 2v7uC-5lmzA:
42.9
2v7uC-5lmzA:
87.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmz FLUORINASE

(Streptomyces
sp. MA37)
PF01887
(SAM_adeno_trans)
8 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ARG A 270
ALA A 276
None
1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
None
1DA  A 301 (-3.3A)
None
None
1DA  A 301 (-3.0A)
0.69A 2v7uC-5lmzA:
42.9
2v7uC-5lmzA:
87.00