SIMILAR PATTERNS OF AMINO ACIDS FOR 2V7U_B_SAMB1300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		5 LEU A 298
ASP A 302
SER A 291
TRP A   8
THR A  10
 None
 1.46A 2v7uB-1biyA:
2.3		 2v7uB-1biyA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 LEU A 640
ASP A 638
SER A 639
TYR A 587
PHE A 590
 None
 1.49A 2v7uB-1kv9A:
0.0		 2v7uB-1kv9A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		5 LEU A 298
ASP A 302
SER A 291
TRP A   8
THR A  10
 None
 1.48A 2v7uB-1n76A:
0.3		 2v7uB-1n76A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		5 LEU A 298
ASP A 302
SER A 291
TRP A   8
THR A  10
 None
 1.40A 2v7uB-1qjmA:
2.0		 2v7uB-1qjmA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum) 		PF12697
(Abhydrolase_6) 		5 ASP A 185
LEU A 186
SER A 115
THR A  54
THR A  59
 None
 1.32A 2v7uB-1y7iA:
2.9		 2v7uB-1y7iA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE

(Streptomyces
cattleya) 		PF01887
(SAM_adeno_trans) 		9 ASP A  16
LEU A  17
ASP A  21
SER A  23
TRP A  50
THR A  76
TYR A  77
THR A  80
PHE A 156
 SA8  A1299 (-2.9A)
SA8  A1299 ( 4.8A)
SA8  A1299 (-3.7A)
SA8  A1299 (-3.1A)
SA8  A1299 (-4.2A)
SA8  A1299 ( 4.7A)
None
SA8  A1299 (-4.0A)
SA8  A1299 (-3.5A)
 0.19A 2v7uB-2c4tA:
46.7		 2v7uB-2c4tA:
99.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsc STREPTOLYSIN O

(Streptococcus
pyogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		5 ASP X 205
LEU X 206
THR X 303
TYR X 344
PHE X 422
 None
 1.37A 2v7uB-4hscX:
0.0		 2v7uB-4hscX:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		5 ASP A 296
ASP A 288
SER A 290
TYR A 298
PHE A 301
 None
 1.40A 2v7uB-5jwzA:
0.0		 2v7uB-5jwzA:
17.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		9 ASP A  16
LEU A  17
ASP A  21
SER A  23
TRP A  50
THR A  76
TYR A  77
THR A  80
PHE A 156
 None
None
None
None
None
None
CL  A 302 ( 4.6A)
None
None
 0.32A 2v7uB-5lmzA:
42.9		 2v7uB-5lmzA:
87.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu8 HYPOTHETICAL PROTEIN
PH0463

(Pyrococcus
horikoshii) 		PF01887
(SAM_adeno_trans) 		6 ASP A 179
PHE A 181
ASN A 183
SER A 226
ALA A 233
ASN A 235
 None
 1.09A 2v7uC-1wu8A:
26.8		 2v7uC-1wu8A:
28.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE

(Streptomyces
cattleya) 		PF01887
(SAM_adeno_trans) 		9 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ARG A 270
ALA A 276
ASN A 278
 None
 0.20A 2v7uC-2c4tA:
46.9		 2v7uC-2c4tA:
99.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG

(Thermus
thermophilus) 		PF01887
(SAM_adeno_trans) 		6 ASP A 182
PHE A 184
ASN A 186
SER A 227
ALA A 234
ASN A 236
 None
 0.91A 2v7uC-2cw5A:
23.2		 2v7uC-2cw5A:
29.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q6k CHLORINASE

(Salinispora
tropica) 		PF01887
(SAM_adeno_trans) 		7 ASP A 183
PHE A 186
ASN A 188
TRP A 190
PHE A 228
SER A 242
ASN A 251
 PEG  A 402 (-2.9A)
None
None
None
None
PEG  A 402 (-3.3A)
None
 0.77A 2v7uC-2q6kA:
31.5		 2v7uC-2q6kA:
38.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbv UNCHARACTERIZED
CONSERVED PROTEIN

(Thermotoga
maritima) 		PF01887
(SAM_adeno_trans) 		7 ASP A 178
PHE A 180
ASN A 182
PHE A 220
SER A 234
ALA A 241
ASN A 243
 None
 0.86A 2v7uC-2zbvA:
30.6		 2v7uC-2zbvA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzh PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pyogenes) 		PF09704
(Cas_Cas5d) 		5 PHE A 101
ASN A  55
PHE A  99
SER A 126
ARG A 132
 None
 1.14A 2v7uC-3vzhA:
0.0		 2v7uC-3vzhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0j UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF09704
(Cas_Cas5d) 		5 PHE A 103
ASN A  57
PHE A 101
SER A 128
ARG A 134
 None
None
None
SO4  A 303 ( 4.7A)
SO4  A 303 (-4.1A)
 1.20A 2v7uC-4r0jA:
0.0		 2v7uC-4r0jA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		8 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ALA A 276
ASN A 278
 None
1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
None
1DA  A 301 (-3.3A)
None
1DA  A 301 (-3.0A)
1DA  A 301 ( 4.4A)
 0.35A 2v7uC-5lmzA:
42.9		 2v7uC-5lmzA:
87.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		8 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ARG A 270
ALA A 276
 None
1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
None
1DA  A 301 (-3.3A)
None
None
1DA  A 301 (-3.0A)
 0.69A 2v7uC-5lmzA:
42.9		 2v7uC-5lmzA:
87.00