SIMILAR PATTERNS OF AMINO ACIDS FOR 2V7U_A_SAMA1299_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		5 LEU A 298
ASP A 302
SER A 291
TRP A   8
THR A  10
 None
 1.46A 2v7uC-1biyA:
2.3		 2v7uC-1biyA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		5 LEU A 298
ASP A 302
SER A 291
TRP A   8
THR A  10
 None
 1.47A 2v7uC-1n76A:
0.4		 2v7uC-1n76A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		5 LEU A 298
ASP A 302
SER A 291
TRP A   8
THR A  10
 None
 1.40A 2v7uC-1qjmA:
0.6		 2v7uC-1qjmA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum) 		PF12697
(Abhydrolase_6) 		5 ASP A 185
LEU A 186
SER A 115
THR A  54
THR A  59
 None
 1.31A 2v7uC-1y7iA:
3.1		 2v7uC-1y7iA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE

(Streptomyces
cattleya) 		PF01887
(SAM_adeno_trans) 		9 ASP A  16
LEU A  17
ASP A  21
SER A  23
TRP A  50
THR A  76
TYR A  77
THR A  80
PHE A 156
 SA8  A1299 (-2.9A)
SA8  A1299 ( 4.8A)
SA8  A1299 (-3.7A)
SA8  A1299 (-3.1A)
SA8  A1299 (-4.2A)
SA8  A1299 ( 4.7A)
None
SA8  A1299 (-4.0A)
SA8  A1299 (-3.5A)
 0.18A 2v7uC-2c4tA:
46.9		 2v7uC-2c4tA:
99.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsc STREPTOLYSIN O

(Streptococcus
pyogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		5 ASP X 205
LEU X 206
THR X 303
TYR X 344
PHE X 422
 None
 1.36A 2v7uC-4hscX:
0.0		 2v7uC-4hscX:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		5 ASP A 296
ASP A 288
SER A 290
TYR A 298
PHE A 301
 None
 1.40A 2v7uC-5jwzA:
0.0		 2v7uC-5jwzA:
17.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		9 ASP A  16
LEU A  17
ASP A  21
SER A  23
TRP A  50
THR A  76
TYR A  77
THR A  80
PHE A 156
 None
None
None
None
None
None
CL  A 302 ( 4.6A)
None
None
 0.30A 2v7uC-5lmzA:
42.9		 2v7uC-5lmzA:
87.00