SIMILAR PATTERNS OF AMINO ACIDS FOR 2V7U_A_SAMA1299_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfv MONOCLONAL ANTIBODY
FV4155
MONOCLONAL ANTIBODY
FV4155


(Mus musculus;
Mus musculus)
PF07686
(V-set)
PF07686
(V-set)
4 ASP H 107
ASN H 100
SER L  61
ALA H 102
None
1.14A 2v7uA-1cfvH:
undetectable
2v7uA-1cfvH:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f20 NITRIC-OXIDE
SYNTHASE


(Rattus
norvegicus)
PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1)
4 ASP A1289
PHE A1281
SER A1313
ARG A1314
None
None
NAP  A1502 (-2.6A)
NAP  A1502 (-4.0A)
1.14A 2v7uA-1f20A:
2.1
2v7uA-1f20A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyl HYPODERMA LINEATUM
COLLAGENASE


(Hypoderma
lineatum)
PF00089
(Trypsin)
4 ASP A 102
PHE A  94
SER A 195
ALA A 104
None
1.01A 2v7uA-1hylA:
undetectable
2v7uA-1hylA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA


(Bacillus
thuringiensis)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid)
4 ASN A 416
SER A 397
ARG A 405
ALA A 277
None
1.00A 2v7uA-1i5pA:
undetectable
2v7uA-1i5pA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id1 PUTATIVE POTASSIUM
CHANNEL PROTEIN


(Escherichia
coli)
PF02254
(TrkA_N)
4 ASP A  84
ASN A  87
SER A 126
ALA A  79
None
1.03A 2v7uA-1id1A:
undetectable
2v7uA-1id1A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kig FACTOR XA

(Bos taurus)
PF00089
(Trypsin)
4 ASP H 102
PHE H  94
SER H 195
ALA H 104
None
1.15A 2v7uA-1kigH:
undetectable
2v7uA-1kigH:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poi GLUTACONATE COENZYME
A-TRANSFERASE
GLUTACONATE COENZYME
A-TRANSFERASE


(Acidaminococcus
fermentans;
Acidaminococcus
fermentans)
PF01144
(CoA_trans)
PF01144
(CoA_trans)
4 ASP A 100
ASN A  72
PHE A  87
SER B 121
None
1.17A 2v7uA-1poiA:
undetectable
2v7uA-1poiA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qso HPA2 HISTONE
ACETYLTRANSFERASE


(Saccharomyces
cerevisiae)
PF00583
(Acetyltransf_1)
4 ASP A  92
ASN A  74
PHE A  49
ALA A  58
None
0.97A 2v7uA-1qsoA:
undetectable
2v7uA-1qsoA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r76 PECTATE LYASE

(Niveispirillum
irakense)
PF09492
(Pec_lyase)
4 ASP A 230
PHE A 213
SER A  59
ALA A 298
None
1.04A 2v7uA-1r76A:
undetectable
2v7uA-1r76A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
SMALL SUBUNIT


(Rhodococcus
jostii)
PF00866
(Ring_hydroxyl_B)
4 PHE B 186
PHE B  42
SER B 107
ARG B 137
None
1.09A 2v7uA-1uliB:
undetectable
2v7uA-1uliB:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE


(Plasmodium
falciparum)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 PHE A 412
ASN A 409
SER A 404
ALA A 227
None
1.16A 2v7uA-1v8bA:
2.3
2v7uA-1v8bA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu7 HISTIDYL-TRNA
SYNTHETASE


(Thermoplasma
acidophilum)
PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His)
4 PHE A  39
PHE A 310
SER A 147
ARG A 151
None
1.06A 2v7uA-1wu7A:
undetectable
2v7uA-1wu7A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu8 HYPOTHETICAL PROTEIN
PH0463


(Pyrococcus
horikoshii)
PF01887
(SAM_adeno_trans)
5 ASP A 179
PHE A 181
ASN A 183
SER A 226
ALA A 233
None
1.10A 2v7uA-1wu8A:
26.7
2v7uA-1wu8A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvv CHITINASE C

(Streptomyces
griseus)
PF00182
(Glyco_hydro_19)
4 ASN A 143
PHE A 249
SER A 272
ALA A 139
None
1.12A 2v7uA-1wvvA:
undetectable
2v7uA-1wvvA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus)
PF00264
(Tyrosinase)
4 ASN A   6
SER A  89
ARG A 153
ALA A   8
None
1.13A 2v7uA-1wx4A:
undetectable
2v7uA-1wx4A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpw LOC51668 PROTEIN

(Homo sapiens)
PF00754
(F5_F8_type_C)
4 PHE A 125
PHE A  45
SER A  20
ALA A 121
None
1.12A 2v7uA-1xpwA:
undetectable
2v7uA-1xpwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1p ALDEHYDE REDUCTASE
II


(Sporidiobolus
salmonicolor)
PF01370
(Epimerase)
4 PHE A 214
PHE A  23
SER A 249
ARG A 328
ACT  A 803 (-4.5A)
None
None
SO4  A 801 (-3.4A)
0.66A 2v7uA-1y1pA:
undetectable
2v7uA-1y1pA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2i AMMONIUM TRANSPORTER

(Archaeoglobus
fulgidus)
PF00909
(Ammonium_transp)
4 ASP A 149
TRP A 137
PHE A 266
SER A 208
None
0.93A 2v7uA-2b2iA:
undetectable
2v7uA-2b2iA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR


(Homo sapiens)
PF13516
(LRR_6)
4 ASP A 435
ASN A 406
SER A 460
ALA A 377
None
1.02A 2v7uA-2bexA:
undetectable
2v7uA-2bexA:
19.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE


(Streptomyces
cattleya)
PF01887
(SAM_adeno_trans)
8 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ARG A 270
ALA A 276
None
0.18A 2v7uA-2c4tA:
47.1
2v7uA-2c4tA:
99.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE


(Pyrococcus
furiosus)
PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C)
4 ASP A 429
PHE A 312
ARG A 269
ALA A 529
None
None
AMP  A1563 (-3.4A)
None
1.18A 2v7uA-2cfmA:
undetectable
2v7uA-2cfmA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG


(Thermus
thermophilus)
PF01887
(SAM_adeno_trans)
5 ASP A 182
PHE A 184
ASN A 186
SER A 227
ALA A 234
None
0.96A 2v7uA-2cw5A:
23.2
2v7uA-2cw5A:
29.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ea3 CHYMOTRYPSIN

(Cellulomonas
bogoriensis)
PF00089
(Trypsin)
4 ASP A  56
PHE A  52
SER A 137
ALA A  58
None
0.89A 2v7uA-2ea3A:
undetectable
2v7uA-2ea3A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN


(Homo sapiens)
PF00089
(Trypsin)
4 ASP A 102
PHE A  94
SER A 195
ALA A 104
None
None
DT8  A 700 ( 3.9A)
None
1.01A 2v7uA-2ei8A:
undetectable
2v7uA-2ei8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4n HYPOTHETICAL PROTEIN
MJ1651


(Methanocaldococcus
jannaschii)
PF01887
(SAM_adeno_trans)
4 ASP A 179
PHE A 181
ASN A 183
SER A 236
None
0.73A 2v7uA-2f4nA:
8.4
2v7uA-2f4nA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)


(Homo sapiens)
PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP)
4 ASP A 219
PHE A 429
SER A 157
ARG A 158
None
1.00A 2v7uA-2hgsA:
undetectable
2v7uA-2hgsA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE


(Trypanosoma
brucei)
PF00288
(GHMP_kinases_N)
4 PHE A 299
PHE A 301
SER A  38
ARG A 149
None
1.01A 2v7uA-2hkeA:
undetectable
2v7uA-2hkeA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT


(Aromatoleum
aromaticum)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
4 PHE A 462
PHE A 814
SER A 468
ALA A 812
None
1.17A 2v7uA-2ivfA:
3.0
2v7uA-2ivfA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 HYPOTHETICAL PROTEIN
YPL007C


(Saccharomyces
cerevisiae)
PF12660
(zf-TFIIIC)
4 PHE A 324
ASN A 326
TRP A 321
SER A 318
None
1.06A 2v7uA-2j04A:
undetectable
2v7uA-2j04A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens)
PF00089
(Trypsin)
PF00092
(VWA)
4 ASP A 541
PHE A 524
SER A 659
ALA A 543
None
0.96A 2v7uA-2odpA:
undetectable
2v7uA-2odpA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oua SERINE PROTEASE

(Nocardiopsis
alba)
PF00089
(Trypsin)
4 ASP A 102
PHE A  94
SER A 195
ALA A 104
None
None
AES  A9001 (-2.5A)
None
0.95A 2v7uA-2ouaA:
undetectable
2v7uA-2ouaA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q6k CHLORINASE

(Salinispora
tropica)
PF01887
(SAM_adeno_trans)
6 ASP A 183
PHE A 186
ASN A 188
TRP A 190
PHE A 228
SER A 242
PEG  A 402 (-2.9A)
None
None
None
None
PEG  A 402 (-3.3A)
0.82A 2v7uA-2q6kA:
31.5
2v7uA-2q6kA:
38.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE


(Homo sapiens)
PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1)
4 ASP A 586
PHE A 578
SER A 610
ARG A 611
None
None
NAP  A 701 (-2.7A)
NAP  A 701 (-3.9A)
1.15A 2v7uA-2qtzA:
3.8
2v7uA-2qtzA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2


(Neurospora
crassa)
PF02171
(Piwi)
4 ASN A 729
SER A 688
ARG A 722
ALA A 731
None
1.11A 2v7uA-2yhaA:
undetectable
2v7uA-2yhaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbv UNCHARACTERIZED
CONSERVED PROTEIN


(Thermotoga
maritima)
PF01887
(SAM_adeno_trans)
6 ASP A 178
PHE A 180
ASN A 182
PHE A 220
SER A 234
ALA A 241
None
0.87A 2v7uA-2zbvA:
30.5
2v7uA-2zbvA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING


(Klebsiella
pneumoniae)
PF00393
(6PGD)
PF03446
(NAD_binding_2)
4 ASP A 376
PHE A 393
ARG A 361
ALA A 390
None
1.19A 2v7uA-2zygA:
undetectable
2v7uA-2zygA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE


(Mesorhizobium
japonicum)
PF08241
(Methyltransf_11)
4 PHE A 139
SER A 203
ARG A 127
ALA A 110
None
None
EDO  A 245 (-2.9A)
None
1.18A 2v7uA-3bkwA:
undetectable
2v7uA-3bkwA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2u XYLOSIDASE/ARABINOSI
DASE


(Selenomonas
ruminantium)
PF04616
(Glyco_hydro_43)
PF07081
(DUF1349)
4 ASP A 519
PHE A 400
SER A 404
ALA A 517
None
1.15A 2v7uA-3c2uA:
undetectable
2v7uA-3c2uA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Streptococcus
pneumoniae)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
4 PHE A 367
ASN A 453
PHE A 347
SER A 449
None
1.05A 2v7uA-3ecqA:
undetectable
2v7uA-3ecqA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C


(Homo sapiens)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
4 PHE A 439
PHE A 466
ARG A 429
ALA A  70
None
1.12A 2v7uA-3eh2A:
undetectable
2v7uA-3eh2A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron)
PF12741
(SusD-like)
4 ASP A 467
PHE A  73
ASN A  78
ALA A  77
None
1.15A 2v7uA-3ehmA:
undetectable
2v7uA-3ehmA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger)
PF00723
(Glyco_hydro_15)
4 PHE A 211
ASN A 271
TRP A 202
ALA A 259
None
1.16A 2v7uA-3eqaA:
undetectable
2v7uA-3eqaA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
4 PHE A 318
ASN A 354
SER A 386
ALA A 322
None
1.11A 2v7uA-3gcwA:
5.8
2v7uA-3gcwA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE


(Streptomyces
antibioticus)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 PHE A 283
ASN A 137
SER A 279
ALA A 135
None
0.90A 2v7uA-3gyrA:
undetectable
2v7uA-3gyrA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbd CLASS IV CHITINASE
CHIA4-PA2


(Picea abies)
PF00182
(Glyco_hydro_19)
4 ASN A 109
PHE A 207
SER A 229
ALA A 105
None
1.10A 2v7uA-3hbdA:
undetectable
2v7uA-3hbdA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE


(Aeromonas
sobria)
PF00082
(Peptidase_S8)
PF01483
(P_proprotein)
4 ASP A 170
PHE A 174
SER A 165
ALA A 210
None
0.92A 2v7uA-3hjrA:
4.0
2v7uA-3hjrA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1)
no annotation 4 ASP A 321
ASN A  36
ARG A 283
ALA A 127
None
1.05A 2v7uA-3j4uA:
undetectable
2v7uA-3j4uA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldf PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.776


(Streptococcus
mutans)
PF10672
(Methyltrans_SAM)
4 PHE A 366
ASN A 101
SER A 122
ARG A 154
None
1.10A 2v7uA-3ldfA:
undetectable
2v7uA-3ldfA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5


(Homo sapiens)
PF01094
(ANF_receptor)
4 ASP A 394
SER A  42
ARG A  61
ALA A  71
None
1.01A 2v7uA-3lmkA:
2.7
2v7uA-3lmkA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 PHE A 385
PHE A 351
SER A 332
ARG A 334
None
1.19A 2v7uA-3mosA:
undetectable
2v7uA-3mosA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moy PROBABLE ENOYL-COA
HYDRATASE


(Mycolicibacterium
smegmatis)
PF00378
(ECH_1)
4 PHE A  63
PHE A 129
SER A 179
ALA A 127
None
0.95A 2v7uA-3moyA:
undetectable
2v7uA-3moyA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaj PUTATIVE
RING-CLEAVING
DIOXYGENASE MHQO


(Bacillus
subtilis)
PF00903
(Glyoxalase)
4 ASP A  42
ASN A  40
PHE A  65
ARG A 247
None
1.09A 2v7uA-3oajA:
undetectable
2v7uA-3oajA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocd SOXA

(Starkeya
novella)
no annotation 4 ASP A 148
ASN A 145
PHE A  50
SER A 272
None
1.06A 2v7uA-3ocdA:
undetectable
2v7uA-3ocdA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
4 ASN A 421
PHE A 465
SER A 426
ALA A 448
None
0.88A 2v7uA-3pocA:
undetectable
2v7uA-3pocA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1


(Mus musculus)
PF00784
(MyTH4)
4 ASP A1551
ASN A1548
SER A1521
ARG A1553
None
0.98A 2v7uA-3pvlA:
undetectable
2v7uA-3pvlA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
4 PHE A 280
ASN A 558
PHE A 282
SER A 565
None
1.09A 2v7uA-3sunA:
undetectable
2v7uA-3sunA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ure ALPHA-LYTIC PROTEASE

(Lysobacter
enzymogenes)
PF00089
(Trypsin)
4 ASP A 102
PHE A  94
SER A 195
ALA A 104
None
None
SO4  A 304 (-2.8A)
None
0.89A 2v7uA-3ureA:
undetectable
2v7uA-3ureA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v64 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4


(Rattus
norvegicus)
PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition)
4 ASN C 667
PHE C 669
SER C 432
ARG C 427
None
1.17A 2v7uA-3v64C:
undetectable
2v7uA-3v64C:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzh PUTATIVE
UNCHARACTERIZED
PROTEIN


(Streptococcus
pyogenes)
PF09704
(Cas_Cas5d)
5 PHE A 101
ASN A  55
PHE A  99
SER A 126
ARG A 132
None
1.14A 2v7uA-3vzhA:
undetectable
2v7uA-3vzhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN


(Pyrococcus sp.
ST04)
no annotation 4 ASP A 253
PHE A 218
SER A 318
ALA A 217
None
0.81A 2v7uA-4cmrA:
undetectable
2v7uA-4cmrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqk BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE


(Bacillus
megaterium)
PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1)
4 ASP A 943
PHE A 935
SER A 966
ARG A 967
None
None
SO4  A1103 (-2.8A)
SO4  A1103 (-3.7A)
1.13A 2v7uA-4dqkA:
2.2
2v7uA-4dqkA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE


(Brucella
melitensis)
no annotation 4 ASP D  51
PHE D  38
PHE D  31
SER D 427
None
1.18A 2v7uA-4em6D:
undetectable
2v7uA-4em6D:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc9 UNCHARACTERIZED
PROTEIN


(Xanthomonas
euvesicatoria)
no annotation 4 PHE B 527
SER B 540
ARG B 541
ALA B 532
None
1.18A 2v7uA-4fc9B:
undetectable
2v7uA-4fc9B:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g5e 2,4,6-TRICHLOROPHENO
L 4-MONOOXYGENASE


(Cupriavidus
pinatubonensis)
PF03241
(HpaB)
PF11794
(HpaB_N)
4 PHE A 374
PHE A 333
ARG A 367
ALA A 301
None
1.09A 2v7uA-4g5eA:
undetectable
2v7uA-4g5eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC


(Synechococcus
elongatus)
PF06745
(ATPase)
4 ASP A 122
PHE A  76
ARG A 166
ALA A 108
None
0.78A 2v7uA-4ijmA:
undetectable
2v7uA-4ijmA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3


(Homo sapiens)
PF00089
(Trypsin)
4 ASP E 534
PHE E 526
SER E 645
ALA E 536
None
1.11A 2v7uA-4iw4E:
undetectable
2v7uA-4iw4E:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nt1 ACCELERATED-CELL-DEA
TH 11


(Arabidopsis
thaliana)
PF08718
(GLTP)
4 PHE A  36
PHE A  17
SER A  44
ALA A  16
None
0.89A 2v7uA-4nt1A:
undetectable
2v7uA-4nt1A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
4 PHE B 318
ASN B 354
SER B 386
ALA B 322
None
1.20A 2v7uA-4ov6B:
5.9
2v7uA-4ov6B:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyi HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE


(Bacillus
anthracis)
PF00156
(Pribosyltran)
4 PHE A  45
PHE A  63
ARG A  53
ALA A  39
None
0.88A 2v7uA-4qyiA:
undetectable
2v7uA-4qyiA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN


(Homo sapiens)
PF00089
(Trypsin)
4 ASP A 102
PHE A  94
SER A 195
ALA A 104
None
None
3KM  A 900 (-3.6A)
None
1.13A 2v7uA-4r0iA:
undetectable
2v7uA-4r0iA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0j UNCHARACTERIZED
PROTEIN


(Streptococcus
mutans)
PF09704
(Cas_Cas5d)
5 PHE A 103
ASN A  57
PHE A 101
SER A 128
ARG A 134
None
None
None
SO4  A 303 ( 4.7A)
SO4  A 303 (-4.1A)
1.21A 2v7uA-4r0jA:
undetectable
2v7uA-4r0jA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1


(Homo sapiens)
PF00571
(CBS)
4 PHE G  61
PHE G  51
ARG G 152
ALA G  63
None
None
AMP  G 401 (-3.7A)
None
1.12A 2v7uA-4rerG:
undetectable
2v7uA-4rerG:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus)
PF01966
(HD)
4 ASP A 546
PHE A 290
PHE A 529
ALA A 541
None
1.17A 2v7uA-4uw2A:
undetectable
2v7uA-4uw2A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Streptococcus
pneumoniae)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
4 PHE A 367
ASN A 453
PHE A 347
SER A 449
None
1.14A 2v7uA-5a55A:
undetectable
2v7uA-5a55A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2


(Saccharomyces
cerevisiae)
PF00909
(Ammonium_transp)
4 ASP A 186
TRP A 173
PHE A 309
SER A 249
None
1.15A 2v7uA-5aexA:
undetectable
2v7uA-5aexA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1


(Chaetomium
thermophilum)
PF00400
(WD40)
4 PHE B 649
PHE B 680
SER B 595
ALA B 651
None
1.08A 2v7uA-5cxcB:
undetectable
2v7uA-5cxcB:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME


(Listeria
monocytogenes)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35)
4 ASP A 659
PHE A 612
SER A 398
ALA A 657
None
1.05A 2v7uA-5f7uA:
undetectable
2v7uA-5f7uA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE
PROTEASOME SUBUNIT
ALPHA TYPE


(Plasmodium
falciparum;
Plasmodium
falciparum)
PF00227
(Proteasome)
PF10584
(Proteasome_A_N)
PF00227
(Proteasome)
PF10584
(Proteasome_A_N)
4 ASP E  84
PHE E 139
PHE D  10
ALA E  30
None
1.17A 2v7uA-5fmgE:
undetectable
2v7uA-5fmgE:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1


(Thielavia
terrestris)
PF05183
(RdRP)
4 ASP A 591
PHE A 588
ARG A 583
ALA A 649
None
1.15A 2v7uA-5fswA:
2.9
2v7uA-5fswA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT


(Escherichia
coli)
PF00111
(Fer2)
PF01799
(Fer2_2)
4 PHE A 150
SER A 168
ARG A 115
ALA A 219
None
1.04A 2v7uA-5g5gA:
undetectable
2v7uA-5g5gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gll GLYCOSIDE HYDROLASE
FAMILY 43


(uncultured
bacterium)
PF04616
(Glyco_hydro_43)
4 ASP A  74
PHE A  88
SER A 339
ALA A  77
None
GOL  A 403 ( 3.7A)
None
None
1.13A 2v7uA-5gllA:
undetectable
2v7uA-5gllA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7t CLASS IV CHITINASE

(Cryptomeria
japonica)
no annotation 4 ASN A  62
PHE A 161
SER A 183
ALA A  58
None
1.10A 2v7uA-5h7tA:
undetectable
2v7uA-5h7tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw4 NADH PYROPHOSPHATASE

(Escherichia
coli)
PF00293
(NUDIX)
PF09297
(zf-NADH-PPase)
4 ASN A 224
SER A 140
ARG A 227
ALA A 223
None
1.18A 2v7uA-5iw4A:
undetectable
2v7uA-5iw4A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D


(Homo sapiens)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
4 PHE B 705
PHE B 732
ARG B 695
ALA B 336
None
1.14A 2v7uA-5kyuB:
undetectable
2v7uA-5kyuB:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmz FLUORINASE

(Streptomyces
sp. MA37)
PF01887
(SAM_adeno_trans)
7 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ALA A 276
None
1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
None
1DA  A 301 (-3.3A)
None
1DA  A 301 (-3.0A)
0.35A 2v7uA-5lmzA:
42.9
2v7uA-5lmzA:
87.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmz FLUORINASE

(Streptomyces
sp. MA37)
PF01887
(SAM_adeno_trans)
7 ASP A 210
PHE A 213
ASN A 215
TRP A 217
SER A 269
ARG A 270
ALA A 276
None
1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
None
None
None
1DA  A 301 (-3.0A)
0.73A 2v7uA-5lmzA:
42.9
2v7uA-5lmzA:
87.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrr LYTIC ENDOPEPTIDASE
PREPROENZYME


(Lysobacter sp.
XL1)
no annotation 4 ASP A  63
PHE A  59
SER A 144
ALA A  65
None
0.91A 2v7uA-5mrrA:
undetectable
2v7uA-5mrrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyx HEAVY CHAIN

(Homo sapiens)
no annotation 4 ASP H 111
PHE H 112
SER H  33
ALA H  98
None
1.18A 2v7uA-5nyxH:
undetectable
2v7uA-5nyxH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L46,
MITOCHONDRIAL


(Homo sapiens)
PF00297
(Ribosomal_L3)
4 PHE e 234
PHE e 204
ARG e 190
ALA e 236
None
0.98A 2v7uA-5oole:
undetectable
2v7uA-5oole:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td7 ZGC:55652

(Danio rerio)
PF00850
(Hist_deacetyl)
4 ASP A  10
SER A  14
ARG A  15
ALA A 111
None
1.04A 2v7uA-5td7A:
undetectable
2v7uA-5td7A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9)
4 PHE A 318
ASN A 354
SER A 386
ALA A 322
None
1.10A 2v7uA-5vlhA:
5.3
2v7uA-5vlhA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE


(Mus musculus)
no annotation 4 PHE A 267
ASN A 296
SER A 174
ALA A 265
PX8  A 610 (-3.1A)
None
MYR  A 611 ( 4.6A)
None
0.98A 2v7uA-5w7dA:
undetectable
2v7uA-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN


(Homo sapiens)
PF00415
(RCC1)
PF13540
(RCC1_2)
4 ASN A 200
SER A 219
ARG A 221
ALA A 184
None
1.15A 2v7uA-5xgsA:
undetectable
2v7uA-5xgsA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1


(Mus musculus)
no annotation 4 ASN A2161
SER A2168
ARG A2169
ALA A2160
None
1.09A 2v7uA-6b3rA:
undetectable
2v7uA-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN


(Bacteroides
cellulosilyticus)
no annotation 4 PHE A 733
SER A 766
ARG A 723
ALA A 784
None
1.16A 2v7uA-6b6lA:
undetectable
2v7uA-6b6lA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b74 COAGULATION FACTOR
XII


(Homo sapiens)
no annotation 4 ASP B 102
PHE B  94
SER B 195
ALA B 104
None
None
SO4  B 304 ( 2.5A)
None
1.08A 2v7uA-6b74B:
2.5
2v7uA-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8g TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4


(Xenopus
tropicalis)
no annotation 4 PHE A 268
PHE A 280
ARG A 244
ALA A 264
None
1.14A 2v7uA-6c8gA:
undetectable
2v7uA-6c8gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2


(Danio rerio)
no annotation 4 ASP A 154
PHE A 131
SER A 127
ARG A 125
None
0.98A 2v7uA-6d21A:
undetectable
2v7uA-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ej2 BETA-SECRETASE 1

(Homo sapiens)
no annotation 4 ASN A 618
SER A 693
ARG A 706
ALA A 660
None
0.95A 2v7uA-6ej2A:
undetectable
2v7uA-6ej2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger)
no annotation 4 PHE A 211
ASN A 271
TRP A 202
ALA A 259
None
1.15A 2v7uA-6frvA:
undetectable
2v7uA-6frvA:
undetectable