SIMILAR PATTERNS OF AMINO ACIDS FOR 2V7U_A_SAMA1299
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cfv | MONOCLONAL ANTIBODYFV4155MONOCLONAL ANTIBODYFV4155 (Mus musculus;Mus musculus) |
PF07686(V-set)PF07686(V-set) | 4 | ASP H 107ASN H 100SER L 61ALA H 102 | None | 1.14A | 2v7uA-1cfvH:undetectable | 2v7uA-1cfvH:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f20 | NITRIC-OXIDESYNTHASE (Rattusnorvegicus) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 4 | ASP A1289PHE A1281SER A1313ARG A1314 | NoneNoneNAP A1502 (-2.6A)NAP A1502 (-4.0A) | 1.14A | 2v7uA-1f20A:2.1 | 2v7uA-1f20A:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hyl | HYPODERMA LINEATUMCOLLAGENASE (Hypodermalineatum) |
PF00089(Trypsin) | 4 | ASP A 102PHE A 94SER A 195ALA A 104 | None | 1.01A | 2v7uA-1hylA:undetectable | 2v7uA-1hylA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i5p | PESTICIDIAL CRYSTALPROTEIN CRY2AA (Bacillusthuringiensis) |
PF03944(Endotoxin_C)PF03945(Endotoxin_N)PF09131(Endotoxin_mid) | 4 | ASN A 416SER A 397ARG A 405ALA A 277 | None | 1.00A | 2v7uA-1i5pA:undetectable | 2v7uA-1i5pA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1id1 | PUTATIVE POTASSIUMCHANNEL PROTEIN (Escherichiacoli) |
PF02254(TrkA_N) | 4 | ASP A 84ASN A 87SER A 126ALA A 79 | None | 1.03A | 2v7uA-1id1A:undetectable | 2v7uA-1id1A:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kig | FACTOR XA (Bos taurus) |
PF00089(Trypsin) | 4 | ASP H 102PHE H 94SER H 195ALA H 104 | None | 1.15A | 2v7uA-1kigH:undetectable | 2v7uA-1kigH:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1poi | GLUTACONATE COENZYMEA-TRANSFERASEGLUTACONATE COENZYMEA-TRANSFERASE (Acidaminococcusfermentans;Acidaminococcusfermentans) |
PF01144(CoA_trans)PF01144(CoA_trans) | 4 | ASP A 100ASN A 72PHE A 87SER B 121 | None | 1.17A | 2v7uA-1poiA:undetectable | 2v7uA-1poiA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qso | HPA2 HISTONEACETYLTRANSFERASE (Saccharomycescerevisiae) |
PF00583(Acetyltransf_1) | 4 | ASP A 92ASN A 74PHE A 49ALA A 58 | None | 0.97A | 2v7uA-1qsoA:undetectable | 2v7uA-1qsoA:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r76 | PECTATE LYASE (Niveispirillumirakense) |
PF09492(Pec_lyase) | 4 | ASP A 230PHE A 213SER A 59ALA A 298 | None | 1.04A | 2v7uA-1r76A:undetectable | 2v7uA-1r76A:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uli | BIPHENYL DIOXYGENASESMALL SUBUNIT (Rhodococcusjostii) |
PF00866(Ring_hydroxyl_B) | 4 | PHE B 186PHE B 42SER B 107ARG B 137 | None | 1.09A | 2v7uA-1uliB:undetectable | 2v7uA-1uliB:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v8b | ADENOSYLHOMOCYSTEINASE (Plasmodiumfalciparum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | PHE A 412ASN A 409SER A 404ALA A 227 | None | 1.16A | 2v7uA-1v8bA:2.3 | 2v7uA-1v8bA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wu7 | HISTIDYL-TRNASYNTHETASE (Thermoplasmaacidophilum) |
PF03129(HGTP_anticodon)PF13393(tRNA-synt_His) | 4 | PHE A 39PHE A 310SER A 147ARG A 151 | None | 1.06A | 2v7uA-1wu7A:undetectable | 2v7uA-1wu7A:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wu8 | HYPOTHETICAL PROTEINPH0463 (Pyrococcushorikoshii) |
PF01887(SAM_adeno_trans) | 5 | ASP A 179PHE A 181ASN A 183SER A 226ALA A 233 | None | 1.10A | 2v7uA-1wu8A:26.7 | 2v7uA-1wu8A:28.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wvv | CHITINASE C (Streptomycesgriseus) |
PF00182(Glyco_hydro_19) | 4 | ASN A 143PHE A 249SER A 272ALA A 139 | None | 1.12A | 2v7uA-1wvvA:undetectable | 2v7uA-1wvvA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wx4 | TYROSINASE (Streptomycescastaneoglobisporus) |
PF00264(Tyrosinase) | 4 | ASN A 6SER A 89ARG A 153ALA A 8 | None | 1.13A | 2v7uA-1wx4A:undetectable | 2v7uA-1wx4A:24.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xpw | LOC51668 PROTEIN (Homo sapiens) |
PF00754(F5_F8_type_C) | 4 | PHE A 125PHE A 45SER A 20ALA A 121 | None | 1.12A | 2v7uA-1xpwA:undetectable | 2v7uA-1xpwA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y1p | ALDEHYDE REDUCTASEII (Sporidiobolussalmonicolor) |
PF01370(Epimerase) | 4 | PHE A 214PHE A 23SER A 249ARG A 328 | ACT A 803 (-4.5A)NoneNoneSO4 A 801 (-3.4A) | 0.66A | 2v7uA-1y1pA:undetectable | 2v7uA-1y1pA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b2i | AMMONIUM TRANSPORTER (Archaeoglobusfulgidus) |
PF00909(Ammonium_transp) | 4 | ASP A 149TRP A 137PHE A 266SER A 208 | None | 0.93A | 2v7uA-2b2iA:undetectable | 2v7uA-2b2iA:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bex | RIBONUCLEASEINHIBITOR (Homo sapiens) |
PF13516(LRR_6) | 4 | ASP A 435ASN A 406SER A 460ALA A 377 | None | 1.02A | 2v7uA-2bexA:undetectable | 2v7uA-2bexA:19.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2c4t | 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE (Streptomycescattleya) |
PF01887(SAM_adeno_trans) | 8 | ASP A 210PHE A 213ASN A 215TRP A 217PHE A 254SER A 269ARG A 270ALA A 276 | None | 0.18A | 2v7uA-2c4tA:47.1 | 2v7uA-2c4tA:99.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cfm | THERMOSTABLE DNALIGASE (Pyrococcusfuriosus) |
PF01068(DNA_ligase_A_M)PF04675(DNA_ligase_A_N)PF04679(DNA_ligase_A_C) | 4 | ASP A 429PHE A 312ARG A 269ALA A 529 | NoneNoneAMP A1563 (-3.4A)None | 1.18A | 2v7uA-2cfmA:undetectable | 2v7uA-2cfmA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cw5 | BACTERIALFLUORINATING ENZYMEHOMOLOG (Thermusthermophilus) |
PF01887(SAM_adeno_trans) | 5 | ASP A 182PHE A 184ASN A 186SER A 227ALA A 234 | None | 0.96A | 2v7uA-2cw5A:23.2 | 2v7uA-2cw5A:29.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ea3 | CHYMOTRYPSIN (Cellulomonasbogoriensis) |
PF00089(Trypsin) | 4 | ASP A 56PHE A 52SER A 137ALA A 58 | None | 0.89A | 2v7uA-2ea3A:undetectable | 2v7uA-2ea3A:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ei8 | COAGULATION FACTORX, HEAVY CHAIN (Homo sapiens) |
PF00089(Trypsin) | 4 | ASP A 102PHE A 94SER A 195ALA A 104 | NoneNoneDT8 A 700 ( 3.9A)None | 1.01A | 2v7uA-2ei8A:undetectable | 2v7uA-2ei8A:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f4n | HYPOTHETICAL PROTEINMJ1651 (Methanocaldococcusjannaschii) |
PF01887(SAM_adeno_trans) | 4 | ASP A 179PHE A 181ASN A 183SER A 236 | None | 0.73A | 2v7uA-2f4nA:8.4 | 2v7uA-2f4nA:27.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hgs | PROTEIN (GLUTATHIONESYNTHETASE) (Homo sapiens) |
PF03199(GSH_synthase)PF03917(GSH_synth_ATP) | 4 | ASP A 219PHE A 429SER A 157ARG A 158 | None | 1.00A | 2v7uA-2hgsA:undetectable | 2v7uA-2hgsA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hke | DIPHOSPHOMEVALONATEDECARBOXYLASE,PUTATIVE (Trypanosomabrucei) |
PF00288(GHMP_kinases_N) | 4 | PHE A 299PHE A 301SER A 38ARG A 149 | None | 1.01A | 2v7uA-2hkeA:undetectable | 2v7uA-2hkeA:24.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ivf | ETHYLBENZENEDEHYDROGENASEALPHA-SUBUNIT (Aromatoleumaromaticum) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 4 | PHE A 462PHE A 814SER A 468ALA A 812 | None | 1.17A | 2v7uA-2ivfA:3.0 | 2v7uA-2ivfA:13.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j04 | HYPOTHETICAL PROTEINYPL007C (Saccharomycescerevisiae) |
PF12660(zf-TFIIIC) | 4 | PHE A 324ASN A 326TRP A 321SER A 318 | None | 1.06A | 2v7uA-2j04A:undetectable | 2v7uA-2j04A:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2odp | COMPLEMENT C2 (Homo sapiens) |
PF00089(Trypsin)PF00092(VWA) | 4 | ASP A 541PHE A 524SER A 659ALA A 543 | None | 0.96A | 2v7uA-2odpA:undetectable | 2v7uA-2odpA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oua | SERINE PROTEASE (Nocardiopsisalba) |
PF00089(Trypsin) | 4 | ASP A 102PHE A 94SER A 195ALA A 104 | NoneNoneAES A9001 (-2.5A)None | 0.95A | 2v7uA-2ouaA:undetectable | 2v7uA-2ouaA:20.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2q6k | CHLORINASE (Salinisporatropica) |
PF01887(SAM_adeno_trans) | 6 | ASP A 183PHE A 186ASN A 188TRP A 190PHE A 228SER A 242 | PEG A 402 (-2.9A)NoneNoneNoneNonePEG A 402 (-3.3A) | 0.82A | 2v7uA-2q6kA:31.5 | 2v7uA-2q6kA:38.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qtz | METHIONINE SYNTHASEREDUCTASE (Homo sapiens) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 4 | ASP A 586PHE A 578SER A 610ARG A 611 | NoneNoneNAP A 701 (-2.7A)NAP A 701 (-3.9A) | 1.15A | 2v7uA-2qtzA:3.8 | 2v7uA-2qtzA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yha | POST-TRANSCRIPTIONALGENE SILENCINGPROTEIN QDE-2 (Neurosporacrassa) |
PF02171(Piwi) | 4 | ASN A 729SER A 688ARG A 722ALA A 731 | None | 1.11A | 2v7uA-2yhaA:undetectable | 2v7uA-2yhaA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zbv | UNCHARACTERIZEDCONSERVED PROTEIN (Thermotogamaritima) |
PF01887(SAM_adeno_trans) | 6 | ASP A 178PHE A 180ASN A 182PHE A 220SER A 234ALA A 241 | None | 0.87A | 2v7uA-2zbvA:30.5 | 2v7uA-2zbvA:29.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zyg | 6-PHOSPHOGLUCONATEDEHYDROGENASE,DECARBOXYLATING (Klebsiellapneumoniae) |
PF00393(6PGD)PF03446(NAD_binding_2) | 4 | ASP A 376PHE A 393ARG A 361ALA A 390 | None | 1.19A | 2v7uA-2zygA:undetectable | 2v7uA-2zygA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bkw | S-ADENOSYLMETHIONINEDEPENDENTMETHYLTRANSFERASE (Mesorhizobiumjaponicum) |
PF08241(Methyltransf_11) | 4 | PHE A 139SER A 203ARG A 127ALA A 110 | NoneNoneEDO A 245 (-2.9A)None | 1.18A | 2v7uA-3bkwA:undetectable | 2v7uA-3bkwA:24.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c2u | XYLOSIDASE/ARABINOSIDASE (Selenomonasruminantium) |
PF04616(Glyco_hydro_43)PF07081(DUF1349) | 4 | ASP A 519PHE A 400SER A 404ALA A 517 | None | 1.15A | 2v7uA-3c2uA:undetectable | 2v7uA-3c2uA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ecq | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Streptococcuspneumoniae) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 4 | PHE A 367ASN A 453PHE A 347SER A 449 | None | 1.05A | 2v7uA-3ecqA:undetectable | 2v7uA-3ecqA:11.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eh2 | PROTEIN TRANSPORTPROTEIN SEC24C (Homo sapiens) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 4 | PHE A 439PHE A 466ARG A 429ALA A 70 | None | 1.12A | 2v7uA-3eh2A:undetectable | 2v7uA-3eh2A:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ehm | SUSD HOMOLOG (Bacteroidesthetaiotaomicron) |
PF12741(SusD-like) | 4 | ASP A 467PHE A 73ASN A 78ALA A 77 | None | 1.15A | 2v7uA-3ehmA:undetectable | 2v7uA-3ehmA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqa | GLUCOAMYLASE (Aspergillusniger) |
PF00723(Glyco_hydro_15) | 4 | PHE A 211ASN A 271TRP A 202ALA A 259 | None | 1.16A | 2v7uA-3eqaA:undetectable | 2v7uA-3eqaA:23.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gcw | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8) | 4 | PHE A 318ASN A 354SER A 386ALA A 322 | None | 1.11A | 2v7uA-3gcwA:5.8 | 2v7uA-3gcwA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyr | PHENOXAZINONESYNTHASE (Streptomycesantibioticus) |
PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | PHE A 283ASN A 137SER A 279ALA A 135 | None | 0.90A | 2v7uA-3gyrA:undetectable | 2v7uA-3gyrA:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hbd | CLASS IV CHITINASECHIA4-PA2 (Picea abies) |
PF00182(Glyco_hydro_19) | 4 | ASN A 109PHE A 207SER A 229ALA A 105 | None | 1.10A | 2v7uA-3hbdA:undetectable | 2v7uA-3hbdA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hjr | EXTRACELLULAR SERINEPROTEASE (Aeromonassobria) |
PF00082(Peptidase_S8)PF01483(P_proprotein) | 4 | ASP A 170PHE A 174SER A 165ALA A 210 | None | 0.92A | 2v7uA-3hjrA:4.0 | 2v7uA-3hjrA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j4u | MAJOR CAPSID PROTEIN (Bordetellavirus BPP1) |
no annotation | 4 | ASP A 321ASN A 36ARG A 283ALA A 127 | None | 1.05A | 2v7uA-3j4uA:undetectable | 2v7uA-3j4uA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ldf | PUTATIVEUNCHARACTERIZEDPROTEIN SMU.776 (Streptococcusmutans) |
PF10672(Methyltrans_SAM) | 4 | PHE A 366ASN A 101SER A 122ARG A 154 | None | 1.10A | 2v7uA-3ldfA:undetectable | 2v7uA-3ldfA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lmk | METABOTROPICGLUTAMATE RECEPTOR 5 (Homo sapiens) |
PF01094(ANF_receptor) | 4 | ASP A 394SER A 42ARG A 61ALA A 71 | None | 1.01A | 2v7uA-3lmkA:2.7 | 2v7uA-3lmkA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mos | TRANSKETOLASE (Homo sapiens) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | PHE A 385PHE A 351SER A 332ARG A 334 | None | 1.19A | 2v7uA-3mosA:undetectable | 2v7uA-3mosA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3moy | PROBABLE ENOYL-COAHYDRATASE (Mycolicibacteriumsmegmatis) |
PF00378(ECH_1) | 4 | PHE A 63PHE A 129SER A 179ALA A 127 | None | 0.95A | 2v7uA-3moyA:undetectable | 2v7uA-3moyA:24.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oaj | PUTATIVERING-CLEAVINGDIOXYGENASE MHQO (Bacillussubtilis) |
PF00903(Glyoxalase) | 4 | ASP A 42ASN A 40PHE A 65ARG A 247 | None | 1.09A | 2v7uA-3oajA:undetectable | 2v7uA-3oajA:24.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ocd | SOXA (Starkeyanovella) |
no annotation | 4 | ASP A 148ASN A 145PHE A 50SER A 272 | None | 1.06A | 2v7uA-3ocdA:undetectable | 2v7uA-3ocdA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3poc | ALPHA-GLUCOSIDASE (Blautia obeum) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 4 | ASN A 421PHE A 465SER A 426ALA A 448 | None | 0.88A | 2v7uA-3pocA:undetectable | 2v7uA-3pocA:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pvl | MYOSIN VIIA ISOFORM1 (Mus musculus) |
PF00784(MyTH4) | 4 | ASP A1551ASN A1548SER A1521ARG A1553 | None | 0.98A | 2v7uA-3pvlA:undetectable | 2v7uA-3pvlA:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sun | DNA POLYMERASE (Escherichiavirus RB69) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 4 | PHE A 280ASN A 558PHE A 282SER A 565 | None | 1.09A | 2v7uA-3sunA:undetectable | 2v7uA-3sunA:15.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ure | ALPHA-LYTIC PROTEASE (Lysobacterenzymogenes) |
PF00089(Trypsin) | 4 | ASP A 102PHE A 94SER A 195ALA A 104 | NoneNoneSO4 A 304 (-2.8A)None | 0.89A | 2v7uA-3ureA:undetectable | 2v7uA-3ureA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v64 | LOW-DENSITYLIPOPROTEINRECEPTOR-RELATEDPROTEIN 4 (Rattusnorvegicus) |
PF00058(Ldl_recept_b)PF14670(FXa_inhibition) | 4 | ASN C 667PHE C 669SER C 432ARG C 427 | None | 1.17A | 2v7uA-3v64C:undetectable | 2v7uA-3v64C:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vzh | PUTATIVEUNCHARACTERIZEDPROTEIN (Streptococcuspyogenes) |
PF09704(Cas_Cas5d) | 5 | PHE A 101ASN A 55PHE A 99SER A 126ARG A 132 | None | 1.14A | 2v7uA-3vzhA:undetectable | 2v7uA-3vzhA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cmr | GLYCOSYLHYDROLASE/DEACETYLASE FAMILY PROTEIN (Pyrococcus sp.ST04) |
no annotation | 4 | ASP A 253PHE A 218SER A 318ALA A 217 | None | 0.81A | 2v7uA-4cmrA:undetectable | 2v7uA-4cmrA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dqk | BIFUNCTIONALP-450/NADPH-P450REDUCTASE (Bacillusmegaterium) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 4 | ASP A 943PHE A 935SER A 966ARG A 967 | NoneNoneSO4 A1103 (-2.8A)SO4 A1103 (-3.7A) | 1.13A | 2v7uA-4dqkA:2.2 | 2v7uA-4dqkA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4em6 | GLUCOSE-6-PHOSPHATEISOMERASE (Brucellamelitensis) |
no annotation | 4 | ASP D 51PHE D 38PHE D 31SER D 427 | None | 1.18A | 2v7uA-4em6D:undetectable | 2v7uA-4em6D:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fc9 | UNCHARACTERIZEDPROTEIN (Xanthomonaseuvesicatoria) |
no annotation | 4 | PHE B 527SER B 540ARG B 541ALA B 532 | None | 1.18A | 2v7uA-4fc9B:undetectable | 2v7uA-4fc9B:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g5e | 2,4,6-TRICHLOROPHENOL 4-MONOOXYGENASE (Cupriaviduspinatubonensis) |
PF03241(HpaB)PF11794(HpaB_N) | 4 | PHE A 374PHE A 333ARG A 367ALA A 301 | None | 1.09A | 2v7uA-4g5eA:undetectable | 2v7uA-4g5eA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ijm | CIRCADIAN CLOCKPROTEIN KINASE KAIC (Synechococcuselongatus) |
PF06745(ATPase) | 4 | ASP A 122PHE A 76ARG A 166ALA A 108 | None | 0.78A | 2v7uA-4ijmA:undetectable | 2v7uA-4ijmA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iw4 | MANNAN-BINDINGLECTIN SERINEPROTEASE 3 (Homo sapiens) |
PF00089(Trypsin) | 4 | ASP E 534PHE E 526SER E 645ALA E 536 | None | 1.11A | 2v7uA-4iw4E:undetectable | 2v7uA-4iw4E:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nt1 | ACCELERATED-CELL-DEATH 11 (Arabidopsisthaliana) |
PF08718(GLTP) | 4 | PHE A 36PHE A 17SER A 44ALA A 16 | None | 0.89A | 2v7uA-4nt1A:undetectable | 2v7uA-4nt1A:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ov6 | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8) | 4 | PHE B 318ASN B 354SER B 386ALA B 322 | None | 1.20A | 2v7uA-4ov6B:5.9 | 2v7uA-4ov6B:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qyi | HYPOXANTHINEPHOSPHORIBOSYLTRANSFERASE (Bacillusanthracis) |
PF00156(Pribosyltran) | 4 | PHE A 45PHE A 63ARG A 53ALA A 39 | None | 0.88A | 2v7uA-4qyiA:undetectable | 2v7uA-4qyiA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r0i | SUPPRESSOR OFTUMORIGENICITY 14PROTEIN (Homo sapiens) |
PF00089(Trypsin) | 4 | ASP A 102PHE A 94SER A 195ALA A 104 | NoneNone3KM A 900 (-3.6A)None | 1.13A | 2v7uA-4r0iA:undetectable | 2v7uA-4r0iA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r0j | UNCHARACTERIZEDPROTEIN (Streptococcusmutans) |
PF09704(Cas_Cas5d) | 5 | PHE A 103ASN A 57PHE A 101SER A 128ARG A 134 | NoneNoneNoneSO4 A 303 ( 4.7A)SO4 A 303 (-4.1A) | 1.21A | 2v7uA-4r0jA:undetectable | 2v7uA-4r0jA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rer | 5'-AMP-ACTIVATEDPROTEIN KINASESUBUNIT GAMMA-1 (Homo sapiens) |
PF00571(CBS) | 4 | PHE G 61PHE G 51ARG G 152ALA G 63 | NoneNoneAMP G 401 (-3.7A)None | 1.12A | 2v7uA-4rerG:undetectable | 2v7uA-4rerG:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uw2 | CSM1 (Thermococcusonnurineus) |
PF01966(HD) | 4 | ASP A 546PHE A 290PHE A 529ALA A 541 | None | 1.17A | 2v7uA-4uw2A:undetectable | 2v7uA-4uw2A:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a55 | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Streptococcuspneumoniae) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 4 | PHE A 367ASN A 453PHE A 347SER A 449 | None | 1.14A | 2v7uA-5a55A:undetectable | 2v7uA-5a55A:12.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aex | AMMONIUM TRANSPORTERMEP2 (Saccharomycescerevisiae) |
PF00909(Ammonium_transp) | 4 | ASP A 186TRP A 173PHE A 309SER A 249 | None | 1.15A | 2v7uA-5aexA:undetectable | 2v7uA-5aexA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cxc | RIBOSOME BIOGENESISPROTEIN ERB1 (Chaetomiumthermophilum) |
PF00400(WD40) | 4 | PHE B 649PHE B 680SER B 595ALA B 651 | None | 1.08A | 2v7uA-5cxcB:undetectable | 2v7uA-5cxcB:25.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7u | CYCLOALTERNAN-FORMING ENZYME (Listeriamonocytogenes) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16338(DUF4968)PF16990(CBM_35) | 4 | ASP A 659PHE A 612SER A 398ALA A 657 | None | 1.05A | 2v7uA-5f7uA:undetectable | 2v7uA-5f7uA:14.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmg | PROTEASOME SUBUNITALPHA TYPEPROTEASOME SUBUNITALPHA TYPE (Plasmodiumfalciparum;Plasmodiumfalciparum) |
PF00227(Proteasome)PF10584(Proteasome_A_N)PF00227(Proteasome)PF10584(Proteasome_A_N) | 4 | ASP E 84PHE E 139PHE D 10ALA E 30 | None | 1.17A | 2v7uA-5fmgE:undetectable | 2v7uA-5fmgE:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fsw | RNA DEPENDENT RNAPOLYMERASE QDE-1 (Thielaviaterrestris) |
PF05183(RdRP) | 4 | ASP A 591PHE A 588ARG A 583ALA A 649 | None | 1.15A | 2v7uA-5fswA:2.9 | 2v7uA-5fswA:13.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5g | PUTATIVE XANTHINEDEHYDROGENASE YAGTIRON-SULFUR-BINDINGSUBUNIT (Escherichiacoli) |
PF00111(Fer2)PF01799(Fer2_2) | 4 | PHE A 150SER A 168ARG A 115ALA A 219 | None | 1.04A | 2v7uA-5g5gA:undetectable | 2v7uA-5g5gA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gll | GLYCOSIDE HYDROLASEFAMILY 43 (unculturedbacterium) |
PF04616(Glyco_hydro_43) | 4 | ASP A 74PHE A 88SER A 339ALA A 77 | NoneGOL A 403 ( 3.7A)NoneNone | 1.13A | 2v7uA-5gllA:undetectable | 2v7uA-5gllA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h7t | CLASS IV CHITINASE (Cryptomeriajaponica) |
no annotation | 4 | ASN A 62PHE A 161SER A 183ALA A 58 | None | 1.10A | 2v7uA-5h7tA:undetectable | 2v7uA-5h7tA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iw4 | NADH PYROPHOSPHATASE (Escherichiacoli) |
PF00293(NUDIX)PF09297(zf-NADH-PPase) | 4 | ASN A 224SER A 140ARG A 227ALA A 223 | None | 1.18A | 2v7uA-5iw4A:undetectable | 2v7uA-5iw4A:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kyu | PROTEIN TRANSPORTPROTEIN SEC24D (Homo sapiens) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 4 | PHE B 705PHE B 732ARG B 695ALA B 336 | None | 1.14A | 2v7uA-5kyuB:undetectable | 2v7uA-5kyuB:16.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lmz | FLUORINASE (Streptomycessp. MA37) |
PF01887(SAM_adeno_trans) | 7 | ASP A 210PHE A 213ASN A 215TRP A 217PHE A 254SER A 269ALA A 276 | None1DA A 301 (-3.0A)1DA A 301 (-2.0A)None1DA A 301 (-3.3A)None1DA A 301 (-3.0A) | 0.35A | 2v7uA-5lmzA:42.9 | 2v7uA-5lmzA:87.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lmz | FLUORINASE (Streptomycessp. MA37) |
PF01887(SAM_adeno_trans) | 7 | ASP A 210PHE A 213ASN A 215TRP A 217SER A 269ARG A 270ALA A 276 | None1DA A 301 (-3.0A)1DA A 301 (-2.0A)NoneNoneNone1DA A 301 (-3.0A) | 0.73A | 2v7uA-5lmzA:42.9 | 2v7uA-5lmzA:87.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mrr | LYTIC ENDOPEPTIDASEPREPROENZYME (Lysobacter sp.XL1) |
no annotation | 4 | ASP A 63PHE A 59SER A 144ALA A 65 | None | 0.91A | 2v7uA-5mrrA:undetectable | 2v7uA-5mrrA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nyx | HEAVY CHAIN (Homo sapiens) |
no annotation | 4 | ASP H 111PHE H 112SER H 33ALA H 98 | None | 1.18A | 2v7uA-5nyxH:undetectable | 2v7uA-5nyxH:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ool | 39S RIBOSOMALPROTEIN L46,MITOCHONDRIAL (Homo sapiens) |
PF00297(Ribosomal_L3) | 4 | PHE e 234PHE e 204ARG e 190ALA e 236 | None | 0.98A | 2v7uA-5oole:undetectable | 2v7uA-5oole:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5td7 | ZGC:55652 (Danio rerio) |
PF00850(Hist_deacetyl) | 4 | ASP A 10SER A 14ARG A 15ALA A 111 | None | 1.04A | 2v7uA-5td7A:undetectable | 2v7uA-5td7A:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vlh | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8)PF05922(Inhibitor_I9) | 4 | PHE A 318ASN A 354SER A 386ALA A 322 | None | 1.10A | 2v7uA-5vlhA:5.3 | 2v7uA-5vlhA:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w7d | ACYLOXYACYLHYDROLASE (Mus musculus) |
no annotation | 4 | PHE A 267ASN A 296SER A 174ALA A 265 | PX8 A 610 (-3.1A)NoneMYR A 611 ( 4.6A)None | 0.98A | 2v7uA-5w7dA:undetectable | 2v7uA-5w7dA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgs | RCC1-LIKE GEXCHANGINGFACTOR-LIKE PROTEIN (Homo sapiens) |
PF00415(RCC1)PF13540(RCC1_2) | 4 | ASN A 200SER A 219ARG A 221ALA A 184 | None | 1.15A | 2v7uA-5xgsA:undetectable | 2v7uA-5xgsA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b3r | PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT 1 (Mus musculus) |
no annotation | 4 | ASN A2161SER A2168ARG A2169ALA A2160 | None | 1.09A | 2v7uA-6b3rA:undetectable | 2v7uA-6b3rA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b6l | GLYCOSYL HYDROLASEFAMILY 2, SUGARBINDING DOMAINPROTEIN (Bacteroidescellulosilyticus) |
no annotation | 4 | PHE A 733SER A 766ARG A 723ALA A 784 | None | 1.16A | 2v7uA-6b6lA:undetectable | 2v7uA-6b6lA:17.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b74 | COAGULATION FACTORXII (Homo sapiens) |
no annotation | 4 | ASP B 102PHE B 94SER B 195ALA B 104 | NoneNoneSO4 B 304 ( 2.5A)None | 1.08A | 2v7uA-6b74B:2.5 | 2v7uA-6b74B:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c8g | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL, SUBFAMILYV, MEMBER 4 (Xenopustropicalis) |
no annotation | 4 | PHE A 268PHE A 280ARG A 244ALA A 264 | None | 1.14A | 2v7uA-6c8gA:undetectable | 2v7uA-6c8gA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d21 | FERM, RHOGEF ANDPLECKSTRIN DOMAINPROTEIN 2 (Danio rerio) |
no annotation | 4 | ASP A 154PHE A 131SER A 127ARG A 125 | None | 0.98A | 2v7uA-6d21A:undetectable | 2v7uA-6d21A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ej2 | BETA-SECRETASE 1 (Homo sapiens) |
no annotation | 4 | ASN A 618SER A 693ARG A 706ALA A 660 | None | 0.95A | 2v7uA-6ej2A:undetectable | 2v7uA-6ej2A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6frv | GLUCOAMYLASE (Aspergillusniger) |
no annotation | 4 | PHE A 211ASN A 271TRP A 202ALA A 259 | None | 1.15A | 2v7uA-6frvA:undetectable | 2v7uA-6frvA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1biy | LACTOFERRIN (Bubalus bubalis) |
PF00405(Transferrin) | 5 | LEU A 298ASP A 302SER A 291TRP A 8THR A 10 | None | 1.46A | 2v7uC-1biyA:2.3 | 2v7uC-1biyA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n76 | LACTOFERRIN (Homo sapiens) |
PF00405(Transferrin) | 5 | LEU A 298ASP A 302SER A 291TRP A 8THR A 10 | None | 1.47A | 2v7uC-1n76A:0.4 | 2v7uC-1n76A:18.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qjm | LACTOFERRIN (Equus caballus) |
PF00405(Transferrin) | 5 | LEU A 298ASP A 302SER A 291TRP A 8THR A 10 | None | 1.40A | 2v7uC-1qjmA:0.6 | 2v7uC-1qjmA:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y7i | SALICYLICACID-BINDING PROTEIN2 (Nicotianatabacum) |
PF12697(Abhydrolase_6) | 5 | ASP A 185LEU A 186SER A 115THR A 54THR A 59 | None | 1.31A | 2v7uC-1y7iA:3.1 | 2v7uC-1y7iA:22.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2c4t | 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE (Streptomycescattleya) |
PF01887(SAM_adeno_trans) | 9 | ASP A 16LEU A 17ASP A 21SER A 23TRP A 50THR A 76TYR A 77THR A 80PHE A 156 | SA8 A1299 (-2.9A)SA8 A1299 ( 4.8A)SA8 A1299 (-3.7A)SA8 A1299 (-3.1A)SA8 A1299 (-4.2A)SA8 A1299 ( 4.7A)NoneSA8 A1299 (-4.0A)SA8 A1299 (-3.5A) | 0.18A | 2v7uC-2c4tA:46.9 | 2v7uC-2c4tA:99.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hsc | STREPTOLYSIN O (Streptococcuspyogenes) |
PF01289(Thiol_cytolysin)PF17440(Thiol_cytolys_C) | 5 | ASP X 205LEU X 206THR X 303TYR X 344PHE X 422 | None | 1.36A | 2v7uC-4hscX:0.0 | 2v7uC-4hscX:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jwz | CELLULOSE-BINDINGFAMILY II (Streptomycessp. SirexAA-E) |
PF02012(BNR) | 5 | ASP A 296ASP A 288SER A 290TYR A 298PHE A 301 | None | 1.40A | 2v7uC-5jwzA:0.0 | 2v7uC-5jwzA:17.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lmz | FLUORINASE (Streptomycessp. MA37) |
PF01887(SAM_adeno_trans) | 9 | ASP A 16LEU A 17ASP A 21SER A 23TRP A 50THR A 76TYR A 77THR A 80PHE A 156 | NoneNoneNoneNoneNoneNone CL A 302 ( 4.6A)NoneNone | 0.30A | 2v7uC-5lmzA:42.9 | 2v7uC-5lmzA:87.00 |