SIMILAR PATTERNS OF AMINO ACIDS FOR 2V7B_B_BEZB1529

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)

(Rattus
norvegicus) 		PF00171
(Aldedh) 		5 ALA A 411
TYR A 412
GLY A 126
GLY A 414
HIS A 413
 None
 1.34A 2v7bB-1ad3A:
2.4		 2v7bB-1ad3A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amu GRAMICIDIN
SYNTHETASE 1

(Brevibacillus
brevis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 PHE A 234
ALA A 301
GLY A 302
GLY A 324
LYS A 517
 PHE  A 566 ( 4.5A)
PHE  A 566 (-3.4A)
PHE  A 566 ( 3.6A)
PHE  A 566 (-4.7A)
AMP  A 567 ( 2.8A)
 0.65A 2v7bB-1amuA:
45.7		 2v7bB-1amuA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo sapiens) 		PF00080
(Sod_Cu) 		5 ALA A  91
ALA A 226
GLY A  94
GLY A 101
ILE A 119
 None
 1.19A 2v7bB-1do5A:
undetectable		 2v7bB-1do5A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Homo sapiens) 		PF00490
(ALAD) 		5 PHE A 200
ALA A 198
ALA A 230
GLY A 229
GLY A 232
 None
 1.28A 2v7bB-1e51A:
undetectable		 2v7bB-1e51A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanothermobacter
thermautotrophicus) 		PF00296
(Bac_luciferase) 		5 ALA A 202
TYR A 297
ALA A 299
GLY A 300
GLY A   4
 None
None
None
MPO  A 331 ( 4.1A)
None
 1.20A 2v7bB-1f07A:
undetectable		 2v7bB-1f07A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0u PROTEASOME COMPONENT
PUP2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ALA D  41
TYR D 146
GLY D 145
GLY D 140
ILE D 215
 None
 1.13A 2v7bB-1g0uD:
undetectable		 2v7bB-1g0uD:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gr0 INOSITOL-3-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01658
(Inos-1-P_synth) 		5 TYR A 145
ALA A  27
GLY A  24
GLY A  22
ILE A  20
 None
None
NAD  A1000 (-3.3A)
NAD  A1000 (-3.3A)
None
 1.21A 2v7bB-1gr0A:
3.1		 2v7bB-1gr0A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU) 		5 ALA A 162
ALA A 416
GLY A 190
GLY A 194
ILE A 412
 None
 1.11A 2v7bB-1iwpA:
undetectable		 2v7bB-1iwpA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 PHE A 456
ALA A 451
ALA A 570
GLY A 572
ILE A 445
 None
 1.34A 2v7bB-1q3xA:
undetectable		 2v7bB-1q3xA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr0 4'-PHOSPHOPANTETHEIN
YL TRANSFERASE SFP

(Bacillus
subtilis) 		PF01648
(ACPS) 		5 ALA A 203
ALA A  98
GLY A  97
GLY A 105
ILE A 104
 None
 1.23A 2v7bB-1qr0A:
undetectable		 2v7bB-1qr0A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryq DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E''

(Pyrococcus
furiosus) 		PF06093
(Spt4) 		5 ALA A  57
TYR A  56
ALA A  50
GLY A  49
ILE A  36
 None
 1.30A 2v7bB-1ryqA:
undetectable		 2v7bB-1ryqA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uax RIBONUCLEASE HII

(Pyrococcus
horikoshii) 		PF01351
(RNase_HII) 		5 ALA A  91
ALA A  23
GLY A   5
GLY A  21
ILE A 147
 None
 1.25A 2v7bB-1uaxA:
undetectable		 2v7bB-1uaxA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5v AMINOMETHYLTRANSFERA
SE

(Pyrococcus
horikoshii) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 ALA A 155
ALA A 161
GLY A 158
GLY A 203
ILE A 173
 None
 1.19A 2v7bB-1v5vA:
undetectable		 2v7bB-1v5vA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE

(Aeropyrum
pernix) 		PF00793
(DAHP_synth_1) 		5 ALA A 228
ALA A 236
GLY A 235
GLY A 238
ILE A 211
 None
 1.29A 2v7bB-1vs1A:
undetectable		 2v7bB-1vs1A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xat XENOBIOTIC
ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00132
(Hexapep) 		5 ALA A 141
ALA A  69
GLY A  68
GLY A 120
ILE A 119
 None
 1.14A 2v7bB-1xatA:
undetectable		 2v7bB-1xatA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzh CYTOCHROME C
PEROXIDASE

(Rhodobacter
capsulatus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 PHE A 143
ALA A 142
ALA A 161
GLY A  37
ILE A  34
 None
 1.32A 2v7bB-1zzhA:
undetectable		 2v7bB-1zzhA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bty ACETYLGLUTAMATE
KINASE

(Thermotoga
maritima) 		PF00696
(AA_kinase) 		5 ALA A 181
GLY A  30
GLY A  62
HIS A  60
ILE A 102
 NLG  A1284 ( 4.4A)
NLG  A1284 (-2.7A)
NLG  A1284 (-4.0A)
None
None
 1.27A 2v7bB-2btyA:
3.4		 2v7bB-2btyA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfc 2-(R)-HYDROXYPROPYL-
COM DEHYDROGENASE

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		5 ALA A 249
TYR A 247
GLY A 186
GLY A 245
ILE A 210
 None
None
KPC  A1252 (-4.7A)
None
None
 1.02A 2v7bB-2cfcA:
3.4		 2v7bB-2cfcA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dst HYPOTHETICAL PROTEIN
TTHA1544

(Thermus
thermophilus) 		no annotation 5 ALA A  67
ALA A  92
GLY A  90
GLY A  94
HIS A  96
 None
 1.18A 2v7bB-2dstA:
3.1		 2v7bB-2dstA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehh DIHYDRODIPICOLINATE
SYNTHASE

(Aquifex
aeolicus) 		PF00701
(DHDPS) 		5 ALA A  89
ALA A  96
GLY A  98
HIS A  90
ILE A  59
 None
 1.23A 2v7bB-2ehhA:
2.5		 2v7bB-2ehhA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2b AQUAPORIN AQPM

(Methanothermobacter
marburgensis) 		PF00230
(MIP) 		5 ALA A 122
ALA A 127
GLY A 130
GLY A 125
ILE A 124
 None
 1.27A 2v7bB-2f2bA:
undetectable		 2v7bB-2f2bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2b AQUAPORIN AQPM

(Methanothermobacter
marburgensis) 		PF00230
(MIP) 		5 ALA A 122
ALA A 127
GLY A 131
GLY A 125
ILE A 124
 None
 1.15A 2v7bB-2f2bA:
undetectable		 2v7bB-2f2bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jax HYPOTHETICAL PROTEIN
TB31.7

(Mycobacterium
tuberculosis) 		PF00582
(Usp) 		5 ALA A  27
ALA A  20
GLY A 117
GLY A  13
ILE A  14
 None
ATP  A1296 (-2.6A)
ATP  A1296 (-2.5A)
ATP  A1296 (-3.3A)
None
 1.14A 2v7bB-2jaxA:
3.5		 2v7bB-2jaxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		5 ALA A 516
ALA A 607
GLY A 608
GLY A 589
ILE A 590
 None
 0.84A 2v7bB-2o1xA:
2.7		 2v7bB-2o1xA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owa ARFGAP-LIKE FINGER
DOMAIN CONTAINING
PROTEIN

(Cryptosporidium
parvum) 		PF01412
(ArfGap) 		5 PHE A 104
ALA A 100
TYR A 103
GLY A 125
ILE A 131
 None
 0.96A 2v7bB-2owaA:
undetectable		 2v7bB-2owaA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 ALA A 819
ALA A 915
GLY A 916
GLY A 919
ILE A 882
 None
 0.96A 2v7bB-2po4A:
undetectable		 2v7bB-2po4A:
19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		9 PHE A 236
ALA A 237
TYR A 238
ALA A 308
GLY A 309
GLY A 333
HIS A 339
ILE A 340
LYS A 520
 BEZ  A1529 (-4.7A)
BEZ  A1529 ( 3.7A)
BEZ  A1529 (-4.3A)
BEZ  A1529 (-3.6A)
BEZ  A1529 (-3.5A)
BEZ  A1529 (-3.6A)
BEZ  A1529 (-3.8A)
BEZ  A1529 ( 4.9A)
BEZ  A1529 (-2.9A)
 0.09A 2v7bB-2v7bA:
72.2		 2v7bB-2v7bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wab ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00657
(Lipase_GDSL) 		5 PHE A 236
ALA A 239
GLY A 222
GLY A 179
ILE A 192
 None
 1.26A 2v7bB-2wabA:
2.8		 2v7bB-2wabA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF00532
(Peripla_BP_1) 		5 ALA A  49
ALA A  58
GLY A  60
GLY A   6
ILE A  36
 None
 1.18A 2v7bB-2wrzA:
4.6		 2v7bB-2wrzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8u SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
wittichii) 		PF00155
(Aminotran_1_2) 		5 ALA A 325
ALA A 331
GLY A 321
GLY A 189
ILE A 329
 None
 1.25A 2v7bB-2x8uA:
4.3		 2v7bB-2x8uA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ALA A 324
ALA A 234
GLY A 199
GLY A 231
ILE A 224
 None
 1.00A 2v7bB-3aoeA:
5.8		 2v7bB-3aoeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 PHE A 146
ALA A 172
ALA A 166
GLY A 103
GLY A 168
 None
 1.24A 2v7bB-3b96A:
undetectable		 2v7bB-3b96A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3baz HYDROXYPHENYLPYRUVAT
E REDUCTASE

(Plectranthus
scutellarioides) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 160
ALA A 202
GLY A 151
GLY A 153
ILE A 155
 None
None
NAP  A 500 (-3.5A)
NAP  A 500 (-3.1A)
NAP  A 500 (-3.6A)
 1.20A 2v7bB-3bazA:
4.9		 2v7bB-3bazA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD

(Bacillus
anthracis) 		no annotation 5 ALA L 227
TYR L 222
ALA L 218
GLY L 220
ILE L 213
 None
 1.24A 2v7bB-3g9kL:
undetectable		 2v7bB-3g9kL:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltm ALPHA-REP4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 ALA A  40
TYR A  24
ALA A  16
GLY A  44
ILE A  46
 None
 1.33A 2v7bB-3ltmA:
undetectable		 2v7bB-3ltmA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moq NEW ANTIGEN RECEPTOR
VARIABLE
DOMAIN,P3(40)
PEPTIDE FROM AMYLOID
BETA A4 PROTEIN,NEW
ANTIGEN RECEPTOR
VARIABLE DOMAIN

(Homo sapiens;
Orectolobus
maculatus) 		PF03494
(Beta-APP)
PF07686
(V-set) 		5 ALA A  85
ALA A 100
GLY A  99
GLY A 112
ILE A 102
 None
 0.91A 2v7bB-3moqA:
undetectable		 2v7bB-3moqA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqg LIPOPOLYSACCHARIDES
BIOSYNTHESIS
ACETYLTRANSFERASE

(Bordetella
petrii) 		PF00132
(Hexapep) 		5 ALA A 141
ALA A 107
GLY A 106
GLY A 122
ILE A 121
 None
 1.12A 2v7bB-3mqgA:
undetectable		 2v7bB-3mqgA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A 191
ALA A  13
GLY A  12
GLY A 347
ILE A 348
 None
 1.25A 2v7bB-3o04A:
undetectable		 2v7bB-3o04A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqc DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E''

(Pyrococcus
furiosus) 		PF06093
(Spt4) 		5 ALA E  57
TYR E  56
ALA E  50
GLY E  49
ILE E  36
 None
 1.14A 2v7bB-3qqcE:
undetectable		 2v7bB-3qqcE:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rq1 AMINOTRANSFERASE
CLASS I AND II

(Veillonella
parvula) 		PF00155
(Aminotran_1_2) 		5 PHE A  82
ALA A  85
ALA A 270
GLY A 269
ILE A 272
 None
 1.19A 2v7bB-3rq1A:
4.0		 2v7bB-3rq1A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s88 ENVELOPE
GLYCOPROTEIN

(Sudan
ebolavirus) 		PF01611
(Filo_glycop) 		5 PHE I 153
ALA I 152
TYR I 151
GLY I  91
GLY I 149
 None
 1.21A 2v7bB-3s88I:
undetectable		 2v7bB-3s88I:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr7 URACIL-DNA
GLYCOSYLASE

(Coxiella
burnetii) 		PF03167
(UDG) 		5 ALA A  75
TYR A  41
ALA A 132
GLY A 133
ILE A  40
 None
 1.13A 2v7bB-3tr7A:
undetectable		 2v7bB-3tr7A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A

(Burkholderia
thailandensis) 		PF06026
(Rib_5-P_isom_A) 		5 TYR A  54
ALA A  30
GLY A  29
GLY A  56
ILE A  32
 None
 1.28A 2v7bB-3u7jA:
2.3		 2v7bB-3u7jA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upu ATP-DEPENDENT DNA
HELICASE DDA

(Escherichia
virus T4) 		PF13604
(AAA_30) 		5 ALA A 398
ALA A 406
GLY A 432
GLY A 428
ILE A 408
 None
 1.13A 2v7bB-3upuA:
2.6		 2v7bB-3upuA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac3 BIFUNCTIONAL PROTEIN
GLMU

(Streptococcus
pneumoniae) 		PF00132
(Hexapep)
PF00483
(NTP_transferase)
PF14602
(Hexapep_2) 		5 ALA A 339
ALA A 307
GLY A 306
GLY A 304
ILE A 303
 None
 1.16A 2v7bB-4ac3A:
undetectable		 2v7bB-4ac3A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus) 		PF00793
(DAHP_synth_1) 		5 ALA A 213
ALA A 221
GLY A 220
GLY A 223
ILE A 196
 None
 1.27A 2v7bB-4c1lA:
undetectable		 2v7bB-4c1lA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE

(Pseudomonas
aeruginosa) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A 167
ALA A 190
GLY A 191
GLY A 109
ILE A 187
 None
 1.18A 2v7bB-4cvmA:
3.2		 2v7bB-4cvmA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE

(Pseudomonas
aeruginosa) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A 207
ALA A 190
GLY A 191
GLY A 109
ILE A 187
 None
 1.26A 2v7bB-4cvmA:
3.2		 2v7bB-4cvmA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw5 DFNA

(Bacillus
velezensis) 		PF03060
(NMO) 		5 ALA A 536
ALA A 707
GLY A 705
GLY A 559
ILE A 561
 FMN  A1753 ( 3.3A)
FMN  A1753 (-3.6A)
None
FMN  A1753 (-3.0A)
None
 1.13A 2v7bB-4cw5A:
undetectable		 2v7bB-4cw5A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2l 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		no annotation 5 ALA A 321
TYR A 324
ALA A 292
HIS A 325
ILE A 328
 None
 1.35A 2v7bB-4f2lA:
undetectable		 2v7bB-4f2lA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING

(Polaromonas sp.
JS666) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 168
ALA A 213
GLY A 159
GLY A 161
ILE A 163
 None
 1.17A 2v7bB-4g2nA:
5.1		 2v7bB-4g2nA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grs PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE,
2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus;
Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		5 ALA A 284
ALA A 292
GLY A 291
GLY A 294
ILE A 267
 None
 1.26A 2v7bB-4grsA:
undetectable		 2v7bB-4grsA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grw NANOBODY 124C4

(Lama glama) 		PF07686
(V-set) 		5 ALA E  61
TYR E  60
ALA E  58
GLY E  50
ILE E  70
 None
 1.25A 2v7bB-4grwE:
undetectable		 2v7bB-4grwE:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ily CHITOSANASE

(Streptomyces
sp. SirexAA-E) 		PF01374
(Glyco_hydro_46) 		5 PHE A 162
ALA A 156
ALA A  98
GLY A  99
GLY A  85
 None
 1.33A 2v7bB-4ilyA:
undetectable		 2v7bB-4ilyA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzu WXCM-LIKE PROTEIN

(Shewanella
denitrificans) 		PF00132
(Hexapep)
PF05523
(FdtA) 		5 ALA A 137
ALA A 103
GLY A 102
GLY A 118
ILE A 117
 None
 1.19A 2v7bB-4mzuA:
undetectable		 2v7bB-4mzuA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npc SORBITOL
DEHYDROGENASE

(Brucella suis) 		PF13561
(adh_short_C2) 		5 ALA A 162
TYR A 163
ALA A 152
GLY A 153
ILE A 157
 None
 1.11A 2v7bB-4npcA:
4.7		 2v7bB-4npcA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu2 ANTIFREEZE PROTEIN

(Flavobacterium
frigoris) 		PF11999
(DUF3494) 		5 ALA A 261
ALA A  95
GLY A  94
GLY A  80
ILE A  98
 None
 1.25A 2v7bB-4nu2A:
undetectable		 2v7bB-4nu2A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 ALA A 801
ALA A 804
GLY A 814
GLY A 816
ILE A 851
 None
 1.29A 2v7bB-4o9xA:
undetectable		 2v7bB-4o9xA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe6 PUTATIVE ABC
TRANSPORTER

(Thermobispora
bispora) 		PF13407
(Peripla_BP_4) 		5 PHE A 264
ALA A 270
TYR A 273
ALA A 249
GLY A 247
 None
 1.27A 2v7bB-4pe6A:
3.6		 2v7bB-4pe6A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY

(Trichormus
variabilis) 		PF13458
(Peripla_BP_6) 		5 PHE A 316
ALA A 319
TYR A 320
ALA A  76
GLY A  77
 None
None
GOL  A 503 (-4.8A)
GOL  A 503 (-3.5A)
None
 1.34A 2v7bB-4rdcA:
undetectable		 2v7bB-4rdcA:
20.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rlq BENZOATE-COENZYME A
LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		7 ALA A 227
TYR A 228
ALA A 302
GLY A 303
GLY A 327
HIS A 333
ILE A 334
 3SK  A1000 (-3.6A)
3SK  A1000 (-4.8A)
3SK  A1000 ( 3.8A)
3SK  A1000 (-3.3A)
3SK  A1000 (-3.6A)
3SK  A1000 ( 4.1A)
None
 0.32A 2v7bB-4rlqA:
62.0		 2v7bB-4rlqA:
61.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxt SUGAR ABC
TRANSPORTER

(Agrobacterium
tumefaciens) 		PF13407
(Peripla_BP_4) 		5 ALA A 229
ALA A 203
GLY A 205
GLY A 210
ILE A 213
 None
 0.87A 2v7bB-4rxtA:
4.2		 2v7bB-4rxtA:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wv3 ANTHRANILATE-COA
LIGASE

(Stigmatella
aurantiaca) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		6 PHE A 220
ALA A 293
GLY A 318
HIS A 324
ILE A 325
LYS A 506
 3UK  A 601 (-4.3A)
3UK  A 601 (-3.5A)
3UK  A 601 (-3.5A)
3UK  A 601 (-3.6A)
None
3UK  A 601 (-2.5A)
 0.53A 2v7bB-4wv3A:
59.9		 2v7bB-4wv3A:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yac C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		5 ALA A  92
ALA A  23
GLY A  21
GLY A  15
ILE A  36
 NAI  A 500 ( 4.1A)
None
None
NAI  A 500 ( 4.2A)
None
 1.12A 2v7bB-4yacA:
3.8		 2v7bB-4yacA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yer ABC TRANSPORTER
ATP-BINDING PROTEIN

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF13732
(DUF4162) 		5 TYR A 105
GLY A 106
GLY A 102
HIS A 101
ILE A 151
 None
 1.35A 2v7bB-4yerA:
undetectable		 2v7bB-4yerA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ALA A 334
TYR A 331
ALA A 162
GLY A 253
GLY A 216
 None
None
None
None
MO  A 802 ( 3.9A)
 0.82A 2v7bB-4zohA:
2.1		 2v7bB-4zohA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aov GLYOXYLATE REDUCTASE

(Pyrococcus
furiosus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 166
ALA A 211
GLY A 157
GLY A 159
ILE A 161
 None
None
NAP  A1335 (-3.3A)
NAP  A1335 (-3.0A)
NAP  A1335 (-3.5A)
 1.21A 2v7bB-5aovA:
6.1		 2v7bB-5aovA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb5 O-ACETYL-ADP-RIBOSE
DEACETYLASE

(Escherichia
coli) 		no annotation 5 ALA R  24
ALA R 100
GLY R  63
GLY R  83
ILE R 121
 None
 1.21A 2v7bB-5cb5R:
undetectable		 2v7bB-5cb5R:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		5 ALA A 733
ALA A 394
GLY A 398
GLY A 655
ILE A 390
 None
 1.18A 2v7bB-5dkxA:
undetectable		 2v7bB-5dkxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE

(Clostridium
sardiniense) 		PF13561
(adh_short_C2) 		5 ALA A  27
GLY A  30
GLY A  55
ILE A  50
LYS A   2
 None
 0.97A 2v7bB-5epoA:
3.8		 2v7bB-5epoA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esa ANTI-HCV E2
GLYCOPROTEIN FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA A  61
TYR A  60
ALA A  58
GLY A  50
ILE A  70
 None
 1.14A 2v7bB-5esaA:
undetectable		 2v7bB-5esaA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fud O-ACETYL-ADP-RIBOSE
DEACETYLASE

(Oceanobacillus
iheyensis) 		PF01661
(Macro) 		5 ALA A  54
ALA A  47
GLY A  48
GLY A  78
ILE A  86
 None
 1.30A 2v7bB-5fudA:
undetectable		 2v7bB-5fudA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h05 AMYP

(marine
metagenome) 		PF00128
(Alpha-amylase) 		5 ALA A 352
ALA A 260
GLY A 264
GLY A 308
ILE A 310
 CA  A 703 ( 4.9A)
None
None
None
None
 1.05A 2v7bB-5h05A:
undetectable		 2v7bB-5h05A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h35 MEMBRANE PROTEIN
TRIC

(Sulfolobus
solfataricus) 		PF03458
(UPF0126) 		5 PHE C  16
ALA C  44
GLY C  45
GLY C 132
ILE C 136
 None
None
None
PX4  C 303 ( 4.6A)
None
 1.19A 2v7bB-5h35C:
undetectable		 2v7bB-5h35C:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i84 PHOSPHATE-BINDING
PROTEIN PSTS

(Xanthomonas
citri) 		PF12849
(PBP_like_2) 		5 ALA A 189
ALA A  81
GLY A 164
GLY A  63
ILE A  66
 None
None
None
PO4  A 403 ( 3.1A)
PO4  A 404 (-4.2A)
 1.20A 2v7bB-5i84A:
undetectable		 2v7bB-5i84A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA

(Bacillus
subtilis) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 ALA A 146
TYR A 150
ALA A 173
GLY A 174
ILE A 153
 None
 1.21A 2v7bB-5iufA:
undetectable		 2v7bB-5iufA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		5 ALA A  88
ALA A 303
GLY A 304
GLY A 306
ILE A 309
 None
 0.93A 2v7bB-5iuyA:
undetectable		 2v7bB-5iuyA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE

(Acaryochloris
marina) 		no annotation 5 ALA A 518
ALA A 524
GLY A 525
HIS A 520
ILE A 584
 PO4  A 901 ( 4.3A)
None
None
PO4  A 901 (-4.1A)
None
 1.23A 2v7bB-5lpcA:
undetectable		 2v7bB-5lpcA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		5 TYR A  50
ALA A  53
GLY A  52
GLY A  87
ILE A  58
 None
 1.10A 2v7bB-5lq3A:
3.5		 2v7bB-5lq3A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		5 ALA A  94
TYR A  93
ALA A 222
GLY A  85
GLY A  89
 None
None
FAD  A 700 (-4.8A)
FAD  A 700 (-3.6A)
FAD  A 700 (-3.4A)
 1.30A 2v7bB-5mq6A:
undetectable		 2v7bB-5mq6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE

(Nocardia
iowensis) 		PF00501
(AMP-binding) 		5 ALA A 134
ALA A 102
GLY A 231
GLY A  98
HIS A 137
 None
 1.34A 2v7bB-5mscA:
34.3		 2v7bB-5mscA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 5 ALA A 924
TYR A 925
ALA A1256
GLY A1258
HIS A 922
 None
 1.35A 2v7bB-5ng6A:
undetectable		 2v7bB-5ng6A:
17.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5oe5 ANTHRANILATE--COA
LIGASE

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		6 PHE A 209
TYR A 211
ALA A 278
GLY A 279
GLY A 302
HIS A 308
 3UK  A 900 (-4.2A)
3UK  A 900 (-4.0A)
3UK  A 900 ( 2.9A)
3UK  A 900 (-3.2A)
3UK  A 900 (-3.4A)
3UK  A 900 ( 2.8A)
 0.28A 2v7bB-5oe5A:
51.0		 2v7bB-5oe5A:
30.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Brucella canis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA A 250
TYR A 251
ALA A 322
GLY A 323
GLY A 347
 None
 0.67A 2v7bB-5u2aA:
44.6		 2v7bB-5u2aA:
34.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf2 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Neisseria
gonorrhoeae) 		PF06026
(Rib_5-P_isom_A) 		5 PHE A 114
ALA A 108
GLY A  83
GLY A  28
ILE A  27
 None
BTB  A 303 (-3.9A)
EDO  A 306 (-3.2A)
None
None
 1.13A 2v7bB-5uf2A:
2.3		 2v7bB-5uf2A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufh LACI-TYPE
TRANSCRIPTIONAL
REGULATOR

(Bifidobacterium
animalis) 		PF13377
(Peripla_BP_3) 		5 ALA A  68
ALA A 119
GLY A 121
GLY A  66
ILE A  96
 None
 1.29A 2v7bB-5ufhA:
4.9		 2v7bB-5ufhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usc PREPHENATE
DEHYDROGENASE

(Bacillus
anthracis) 		PF02153
(PDH) 		5 ALA A  30
ALA A  80
GLY A  21
GLY A  23
ILE A  25
 None
 1.25A 2v7bB-5uscA:
5.7		 2v7bB-5uscA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCE

(Pseudomonas
aeruginosa) 		PF06833
(MdcE) 		5 ALA A 144
ALA A 114
GLY A  68
GLY A  64
ILE A 111
 None
 1.18A 2v7bB-5vipA:
undetectable		 2v7bB-5vipA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa3 PYRIDINE SYNTHASE
TBTD

(Thermobispora
bispora) 		no annotation 5 PHE A 308
ALA A 307
TYR A 311
ALA A 184
GLY A 179
 None
 1.10A 2v7bB-5wa3A:
undetectable		 2v7bB-5wa3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wl2 -

(-) 		no annotation 5 ALA H  61
TYR H  60
ALA H  58
GLY H  50
ILE H  70
 None
 1.20A 2v7bB-5wl2H:
undetectable		 2v7bB-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4j UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 5 ALA A  83
ALA A 162
GLY A 161
GLY A 138
HIS A 106
 ZN  A 501 ( 4.8A)
None
None
None
ZN  A 501 (-3.3A)
 1.28A 2v7bB-5x4jA:
undetectable		 2v7bB-5x4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9r CITRATE-SODIUM
SYMPORTER

(Klebsiella
pneumoniae) 		PF03390
(2HCT) 		5 ALA A 395
ALA A 155
GLY A 372
GLY A 151
ILE A 152
 None
 1.22A 2v7bB-5x9rA:
undetectable		 2v7bB-5x9rA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR

(Synechocystis
sp. PCC 6803) 		no annotation 5 ALA A 170
ALA A 231
GLY A 234
GLY A 237
ILE A 193
 None
 1.03A 2v7bB-5y2wA:
undetectable		 2v7bB-5y2wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy3 -

(-) 		no annotation 5 PHE A 383
ALA A 377
ALA A 354
GLY A 351
ILE A 372
 None
 1.26A 2v7bB-5yy3A:
undetectable		 2v7bB-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ALA A1186
TYR A1187
ALA A 370
GLY A1172
ILE A 178
 None
None
SO4  A1401 ( 3.9A)
SO4  A1401 (-3.3A)
None
 1.22A 2v7bB-6apxA:
undetectable		 2v7bB-6apxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus) 		no annotation 5 ALA A 164
ALA A 188
GLY A  25
GLY A 149
ILE A 148
 None
 1.28A 2v7bB-6d0nA:
undetectable		 2v7bB-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 5 ALA A 953
ALA A 950
GLY A 992
ILE A 990
LYS A 787
 None
 1.34A 2v7bB-6en4A:
undetectable		 2v7bB-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd PROTEASOME SUBUNIT
BETA TYPE-4

(Rattus
norvegicus) 		no annotation 5 ALA 7  68
ALA 7  97
GLY 7  96
GLY 7 157
ILE 7 156
 None
 1.28A 2v7bB-6epd7:
undetectable		 2v7bB-6epd7:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd PROTEASOME SUBUNIT
BETA TYPE-4

(Rattus
norvegicus) 		no annotation 5 ALA 7  68
ALA 7  97
GLY 7  96
GLY 7 158
ILE 7 156
 None
 1.16A 2v7bB-6epd7:
undetectable		 2v7bB-6epd7:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 5 ALA I 144
ALA I 141
GLY I 140
GLY I 159
ILE I  55
 None
 1.25A 2v7bB-6esqI:
undetectable		 2v7bB-6esqI:
undetectable