SIMILAR PATTERNS OF AMINO ACIDS FOR 2V7B_A_BEZA1529_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ad3 | ALDEHYDEDEHYDROGENASE (CLASS3) (Rattusnorvegicus) |
PF00171(Aldedh) | 5 | ALA A 411TYR A 412GLY A 126GLY A 414HIS A 413 | None | 1.36A | 2v7bA-1ad3A:2.2 | 2v7bA-1ad3A:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1amu | GRAMICIDINSYNTHETASE 1 (Brevibacillusbrevis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | PHE A 234ALA A 301GLY A 302GLY A 324LYS A 517 | PHE A 566 ( 4.5A)PHE A 566 (-3.4A)PHE A 566 ( 3.6A)PHE A 566 (-4.7A)AMP A 567 ( 2.8A) | 0.64A | 2v7bA-1amuA:45.7 | 2v7bA-1amuA:25.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1do5 | HUMAN COPPERCHAPERONE FORSUPEROXIDE DISMUTASEDOMAIN II (Homo sapiens) |
PF00080(Sod_Cu) | 5 | ALA A 91ALA A 226GLY A 94GLY A 101ILE A 119 | None | 1.19A | 2v7bA-1do5A:undetectable | 2v7bA-1do5A:13.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f07 | COENZYMEF420-DEPENDENTN5,N10-METHYLENETETRAHYDROMETHANOPTERINREDUCTASE (Methanothermobacterthermautotrophicus) |
PF00296(Bac_luciferase) | 5 | ALA A 202TYR A 297ALA A 299GLY A 300GLY A 4 | NoneNoneNoneMPO A 331 ( 4.1A)None | 1.19A | 2v7bA-1f07A:undetectable | 2v7bA-1f07A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g0u | PROTEASOME COMPONENTPUP2 (Saccharomycescerevisiae) |
PF00227(Proteasome)PF10584(Proteasome_A_N) | 5 | ALA D 41TYR D 146GLY D 145GLY D 140ILE D 215 | None | 1.13A | 2v7bA-1g0uD:undetectable | 2v7bA-1g0uD:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iwp | GLYCEROL DEHYDRATASEALPHA SUBUNIT (Klebsiellapneumoniae) |
PF02286(Dehydratase_LU) | 5 | ALA A 162ALA A 416GLY A 190GLY A 194ILE A 412 | None | 1.13A | 2v7bA-1iwpA:undetectable | 2v7bA-1iwpA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m64 | FLAVOCYTOCHROME C3 (Shewanellafrigidimarina) |
PF00890(FAD_binding_2)PF14537(Cytochrom_c3_2) | 5 | ALA A 312ALA A 165GLY A 162GLY A 136ILE A 553 | NoneFAD A3000 (-3.3A)NoneFAD A3000 (-4.1A)FAD A3000 (-3.6A) | 1.26A | 2v7bA-1m64A:undetectable | 2v7bA-1m64A:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m64 | FLAVOCYTOCHROME C3 (Shewanellafrigidimarina) |
PF00890(FAD_binding_2)PF14537(Cytochrom_c3_2) | 5 | ALA A 312ALA A 165GLY A 163GLY A 136ILE A 553 | NoneFAD A3000 (-3.3A)FAD A3000 (-3.2A)FAD A3000 (-4.1A)FAD A3000 (-3.6A) | 1.36A | 2v7bA-1m64A:undetectable | 2v7bA-1m64A:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pl0 | BIFUNCTIONAL PURINEBIOSYNTHESIS PROTEINPURH (Homo sapiens) |
PF01808(AICARFT_IMPCHas)PF02142(MGS) | 5 | ALA A 421ALA A 309GLY A 272GLY A 443ILE A 442 | None | 1.36A | 2v7bA-1pl0A:3.5 | 2v7bA-1pl0A:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q3x | MANNAN-BINDINGLECTIN SERINEPROTEASE 2 (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 5 | PHE A 456ALA A 451ALA A 570GLY A 572ILE A 445 | None | 1.35A | 2v7bA-1q3xA:undetectable | 2v7bA-1q3xA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qr0 | 4'-PHOSPHOPANTETHEINYL TRANSFERASE SFP (Bacillussubtilis) |
PF01648(ACPS) | 5 | ALA A 203ALA A 98GLY A 97GLY A 105ILE A 104 | None | 1.23A | 2v7bA-1qr0A:undetectable | 2v7bA-1qr0A:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rrv | GLYCOSYLTRANSFERASEGTFD (Amycolatopsisorientalis) |
PF03033(Glyco_transf_28) | 5 | PHE A 121ALA A 114ALA A 107GLY A 189GLY A 109 | PHE A 121 ( 1.3A)ALA A 114 ( 0.0A)ALA A 107 ( 0.0A)GLY A 189 ( 0.0A)GLY A 109 ( 0.0A) | 1.37A | 2v7bA-1rrvA:4.1 | 2v7bA-1rrvA:25.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ryq | DNA-DIRECTED RNAPOLYMERASE, SUBUNITE'' (Pyrococcusfuriosus) |
PF06093(Spt4) | 5 | ALA A 57TYR A 56ALA A 50GLY A 49ILE A 36 | None | 1.33A | 2v7bA-1ryqA:undetectable | 2v7bA-1ryqA:8.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s2n | EXTRACELLULARSUBTILISIN-LIKESERINE PROTEINASE (Vibrio sp.PA-44) |
PF00082(Peptidase_S8) | 5 | ALA A 4TYR A 22GLY A 84GLY A 7ILE A 11 | None | 1.31A | 2v7bA-1s2nA:2.5 | 2v7bA-1s2nA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sfr | ANTIGEN 85-A (Mycobacteriumtuberculosis) |
PF00756(Esterase) | 5 | PHE A 240ALA A 243TYR A 244GLY A 198ILE A 201 | None | 1.12A | 2v7bA-1sfrA:2.3 | 2v7bA-1sfrA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uax | RIBONUCLEASE HII (Pyrococcushorikoshii) |
PF01351(RNase_HII) | 5 | ALA A 91ALA A 23GLY A 5GLY A 21ILE A 147 | None | 1.26A | 2v7bA-1uaxA:undetectable | 2v7bA-1uaxA:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v19 | 2-KETO-3-DEOXYGLUCONATE KINASE (Thermusthermophilus) |
PF00294(PfkB) | 5 | PHE A 145ALA A 117ALA A 7GLY A 8GLY A 54 | None | 1.31A | 2v7bA-1v19A:2.3 | 2v7bA-1v19A:23.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5v | AMINOMETHYLTRANSFERASE (Pyrococcushorikoshii) |
PF01571(GCV_T)PF08669(GCV_T_C) | 5 | ALA A 155ALA A 161GLY A 158GLY A 203ILE A 173 | None | 1.22A | 2v7bA-1v5vA:undetectable | 2v7bA-1v5vA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vs1 | 3-DEOXY-7-PHOSPHOHEPTULONATE SYNTHASE (Aeropyrumpernix) |
PF00793(DAHP_synth_1) | 5 | ALA A 228ALA A 236GLY A 235GLY A 238ILE A 211 | None | 1.28A | 2v7bA-1vs1A:undetectable | 2v7bA-1vs1A:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xat | XENOBIOTICACETYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00132(Hexapep) | 5 | ALA A 141ALA A 69GLY A 68GLY A 120ILE A 119 | None | 1.12A | 2v7bA-1xatA:undetectable | 2v7bA-1xatA:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yy5 | FMS1 PROTEIN (Saccharomycescerevisiae) |
PF01593(Amino_oxidase) | 5 | ALA A 23ALA A 492GLY A 478GLY A 17ILE A 18 | NoneFAD A 803 (-3.3A)FAD A 803 (-2.9A)FAD A 803 (-3.6A)FAD A 803 (-4.7A) | 1.25A | 2v7bA-1yy5A:undetectable | 2v7bA-1yy5A:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zzh | CYTOCHROME CPEROXIDASE (Rhodobactercapsulatus) |
PF00034(Cytochrom_C)PF03150(CCP_MauG) | 5 | PHE A 143ALA A 142ALA A 161GLY A 37ILE A 34 | None | 1.31A | 2v7bA-1zzhA:undetectable | 2v7bA-1zzhA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bty | ACETYLGLUTAMATEKINASE (Thermotogamaritima) |
PF00696(AA_kinase) | 5 | ALA A 181GLY A 30GLY A 62HIS A 60ILE A 102 | NLG A1284 ( 4.4A)NLG A1284 (-2.7A)NLG A1284 (-4.0A)NoneNone | 1.28A | 2v7bA-2btyA:2.7 | 2v7bA-2btyA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cfc | 2-(R)-HYDROXYPROPYL-COM DEHYDROGENASE (Xanthobacterautotrophicus) |
PF13561(adh_short_C2) | 5 | ALA A 249TYR A 247GLY A 186GLY A 245ILE A 210 | NoneNoneKPC A1252 (-4.7A)NoneNone | 1.04A | 2v7bA-2cfcA:4.4 | 2v7bA-2cfcA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dst | HYPOTHETICAL PROTEINTTHA1544 (Thermusthermophilus) |
no annotation | 5 | ALA A 67ALA A 92GLY A 90GLY A 94HIS A 96 | None | 1.18A | 2v7bA-2dstA:3.1 | 2v7bA-2dstA:14.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ehh | DIHYDRODIPICOLINATESYNTHASE (Aquifexaeolicus) |
PF00701(DHDPS) | 5 | ALA A 89ALA A 96GLY A 98HIS A 90ILE A 59 | None | 1.27A | 2v7bA-2ehhA:2.1 | 2v7bA-2ehhA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gp4 | 6-PHOSPHOGLUCONATEDEHYDRATASE (Shewanellaoneidensis) |
PF00920(ILVD_EDD) | 5 | ALA A 314ALA A 165GLY A 164GLY A 169ILE A 278 | None | 1.27A | 2v7bA-2gp4A:2.6 | 2v7bA-2gp4A:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jax | HYPOTHETICAL PROTEINTB31.7 (Mycobacteriumtuberculosis) |
PF00582(Usp) | 5 | ALA A 27ALA A 20GLY A 117GLY A 13ILE A 14 | NoneATP A1296 (-2.6A)ATP A1296 (-2.5A)ATP A1296 (-3.3A)None | 1.14A | 2v7bA-2jaxA:3.0 | 2v7bA-2jaxA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nqo | GAMMA-GLUTAMYLTRANSPEPTIDASE (Helicobacterpylori) |
PF01019(G_glu_transpept) | 5 | ALA A 237TYR A 232ALA A 228GLY A 230ILE A 223 | None | 1.36A | 2v7bA-2nqoA:undetectable | 2v7bA-2nqoA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o1x | 1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE (Deinococcusradiodurans) |
PF02779(Transket_pyr)PF02780(Transketolase_C)PF13292(DXP_synthase_N) | 5 | ALA A 516ALA A 607GLY A 608GLY A 589ILE A 590 | None | 0.86A | 2v7bA-2o1xA:4.1 | 2v7bA-2o1xA:23.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2owa | ARFGAP-LIKE FINGERDOMAIN CONTAININGPROTEIN (Cryptosporidiumparvum) |
PF01412(ArfGap) | 5 | PHE A 104ALA A 100TYR A 103GLY A 125ILE A 131 | None | 0.95A | 2v7bA-2owaA:undetectable | 2v7bA-2owaA:11.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2po4 | VIRION RNAPOLYMERASE (Escherichiavirus N4) |
no annotation | 5 | ALA A 819ALA A 915GLY A 916GLY A 919ILE A 882 | None | 0.98A | 2v7bA-2po4A:undetectable | 2v7bA-2po4A:19.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2v7b | BENZOATE-COENZYME ALIGASE (Paraburkholderiaxenovorans) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 9 | PHE A 236ALA A 237TYR A 238ALA A 308GLY A 309GLY A 333HIS A 339ILE A 340LYS A 520 | BEZ A1529 (-4.7A)BEZ A1529 ( 3.7A)BEZ A1529 (-4.3A)BEZ A1529 (-3.6A)BEZ A1529 (-3.5A)BEZ A1529 (-3.6A)BEZ A1529 (-3.8A)BEZ A1529 ( 4.9A)BEZ A1529 (-2.9A) | 0.00A | 2v7bA-2v7bA:74.1 | 2v7bA-2v7bA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wab | ENDOGLUCANASE E (Ruminiclostridiumthermocellum) |
PF00657(Lipase_GDSL) | 5 | PHE A 236ALA A 239GLY A 222GLY A 179ILE A 192 | None | 1.25A | 2v7bA-2wabA:2.2 | 2v7bA-2wabA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wrz | L-ARABINOSE-BINDINGPERIPLASMIC PROTEIN (Escherichiacoli) |
PF00532(Peripla_BP_1) | 5 | ALA A 49ALA A 58GLY A 60GLY A 6ILE A 36 | None | 1.21A | 2v7bA-2wrzA:3.2 | 2v7bA-2wrzA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x8u | SERINEPALMITOYLTRANSFERASE (Sphingomonaswittichii) |
PF00155(Aminotran_1_2) | 5 | ALA A 325ALA A 331GLY A 321GLY A 189ILE A 329 | None | 1.26A | 2v7bA-2x8uA:4.6 | 2v7bA-2x8uA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b96 | VERY LONG-CHAINSPECIFIC ACYL-COADEHYDROGENASE (Homo sapiens) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | PHE A 146ALA A 172ALA A 166GLY A 103GLY A 168 | None | 1.24A | 2v7bA-3b96A:undetectable | 2v7bA-3b96A:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrd | NICOTINATEDEHYDROGENASE LARGEMOLYBDOPTERINSUBUNITNICOTINATEDEHYDROGENASE SMALLFES SUBUNIT (Eubacteriumbarkeri;Eubacteriumbarkeri) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2)PF00111(Fer2)PF01799(Fer2_2) | 5 | PHE A 27TYR D 103GLY D 102GLY A 237LYS A 20 | NoneNoneFES D 907 (-4.3A)MCN B 921 (-3.7A)None | 1.35A | 2v7bA-3hrdA:undetectable | 2v7bA-3hrdA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3moq | NEW ANTIGEN RECEPTORVARIABLEDOMAIN,P3(40)PEPTIDE FROM AMYLOIDBETA A4 PROTEIN,NEWANTIGEN RECEPTORVARIABLE DOMAIN (Homo sapiens;Orectolobusmaculatus) |
PF03494(Beta-APP)PF07686(V-set) | 5 | ALA A 85ALA A 100GLY A 99GLY A 112ILE A 102 | None | 0.94A | 2v7bA-3moqA:undetectable | 2v7bA-3moqA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mqg | LIPOPOLYSACCHARIDESBIOSYNTHESISACETYLTRANSFERASE (Bordetellapetrii) |
PF00132(Hexapep) | 5 | ALA A 141ALA A 107GLY A 106GLY A 122ILE A 121 | None | 1.10A | 2v7bA-3mqgA:undetectable | 2v7bA-3mqgA:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o04 | BETA-KETO-ACYLCARRIER PROTEINSYNTHASE II (Listeriamonocytogenes) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ALA A 191ALA A 13GLY A 12GLY A 347ILE A 348 | None | 1.24A | 2v7bA-3o04A:undetectable | 2v7bA-3o04A:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qqc | DNA-DIRECTED RNAPOLYMERASE, SUBUNITE'' (Pyrococcusfuriosus) |
PF06093(Spt4) | 5 | ALA E 57TYR E 56ALA E 50GLY E 49ILE E 36 | None | 1.17A | 2v7bA-3qqcE:undetectable | 2v7bA-3qqcE:7.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rq1 | AMINOTRANSFERASECLASS I AND II (Veillonellaparvula) |
PF00155(Aminotran_1_2) | 5 | PHE A 82ALA A 85ALA A 270GLY A 269ILE A 272 | None | 1.19A | 2v7bA-3rq1A:3.9 | 2v7bA-3rq1A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s88 | ENVELOPEGLYCOPROTEIN (Sudanebolavirus) |
PF01611(Filo_glycop) | 5 | PHE I 153ALA I 152TYR I 151GLY I 91GLY I 149 | None | 1.20A | 2v7bA-3s88I:undetectable | 2v7bA-3s88I:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t4c | 2-DEHYDRO-3-DEOXYPHOSPHOOCTONATEALDOLASE 1 (Burkholderiaambifaria) |
PF00793(DAHP_synth_1) | 5 | PHE A 47ALA A 18TYR A 49ALA A 33GLY A 34 | None | 1.35A | 2v7bA-3t4cA:undetectable | 2v7bA-3t4cA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tr7 | URACIL-DNAGLYCOSYLASE (Coxiellaburnetii) |
PF03167(UDG) | 5 | ALA A 75TYR A 41ALA A 132GLY A 133ILE A 40 | None | 1.13A | 2v7bA-3tr7A:undetectable | 2v7bA-3tr7A:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u7j | RIBOSE-5-PHOSPHATEISOMERASE A (Burkholderiathailandensis) |
PF06026(Rib_5-P_isom_A) | 5 | TYR A 54ALA A 30GLY A 29GLY A 56ILE A 32 | None | 1.28A | 2v7bA-3u7jA:2.5 | 2v7bA-3u7jA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3upu | ATP-DEPENDENT DNAHELICASE DDA (Escherichiavirus T4) |
PF13604(AAA_30) | 5 | ALA A 398ALA A 406GLY A 432GLY A 428ILE A 408 | None | 1.13A | 2v7bA-3upuA:undetectable | 2v7bA-3upuA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ac3 | BIFUNCTIONAL PROTEINGLMU (Streptococcuspneumoniae) |
PF00132(Hexapep)PF00483(NTP_transferase)PF14602(Hexapep_2) | 5 | ALA A 339ALA A 307GLY A 306GLY A 304ILE A 303 | None | 1.19A | 2v7bA-4ac3A:undetectable | 2v7bA-4ac3A:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c1l | 2-DEHYDRO-3-DEOXYPHOSPHOHEPTONATEALDOLASE (Pyrococcusfuriosus) |
PF00793(DAHP_synth_1) | 5 | ALA A 213ALA A 221GLY A 220GLY A 223ILE A 196 | None | 1.25A | 2v7bA-4c1lA:undetectable | 2v7bA-4c1lA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cvm | UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D- ALANINE LIGASE (Pseudomonasaeruginosa) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | ALA A 167ALA A 190GLY A 191GLY A 109ILE A 187 | None | 1.15A | 2v7bA-4cvmA:2.7 | 2v7bA-4cvmA:24.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cvm | UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D- ALANINE LIGASE (Pseudomonasaeruginosa) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | ALA A 207ALA A 190GLY A 191GLY A 109ILE A 187 | None | 1.23A | 2v7bA-4cvmA:2.7 | 2v7bA-4cvmA:24.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cw5 | DFNA (Bacillusvelezensis) |
PF03060(NMO) | 5 | ALA A 536ALA A 707GLY A 705GLY A 559ILE A 561 | FMN A1753 ( 3.3A)FMN A1753 (-3.6A)NoneFMN A1753 (-3.0A)None | 1.14A | 2v7bA-4cw5A:undetectable | 2v7bA-4cw5A:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f2l | 5'-AMP-ACTIVATEDPROTEIN KINASECATALYTIC SUBUNITALPHA-1 (Rattusnorvegicus) |
no annotation | 5 | ALA A 321TYR A 324ALA A 292HIS A 325ILE A 328 | None | 1.34A | 2v7bA-4f2lA:undetectable | 2v7bA-4f2lA:7.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g2n | D-ISOMER SPECIFIC2-HYDROXYACIDDEHYDROGENASE,NAD-BINDING (Polaromonas sp.JS666) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | ALA A 168ALA A 213GLY A 159GLY A 161ILE A 163 | None | 1.20A | 2v7bA-4g2nA:5.4 | 2v7bA-4g2nA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4grs | PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATEALDOLASE,2-DEHYDRO-3-DEOXYPHOSPHOHEPTONATEALDOLASE (Pyrococcusfuriosus;Thermotogamaritima) |
PF00793(DAHP_synth_1) | 5 | ALA A 284ALA A 292GLY A 291GLY A 294ILE A 267 | None | 1.25A | 2v7bA-4grsA:undetectable | 2v7bA-4grsA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4grw | NANOBODY 124C4 (Lama glama) |
PF07686(V-set) | 5 | ALA E 61TYR E 60ALA E 58GLY E 50ILE E 70 | None | 1.27A | 2v7bA-4grwE:undetectable | 2v7bA-4grwE:12.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ily | CHITOSANASE (Streptomycessp. SirexAA-E) |
PF01374(Glyco_hydro_46) | 5 | PHE A 162ALA A 156ALA A 98GLY A 99GLY A 85 | None | 1.35A | 2v7bA-4ilyA:undetectable | 2v7bA-4ilyA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mzu | WXCM-LIKE PROTEIN (Shewanelladenitrificans) |
PF00132(Hexapep)PF05523(FdtA) | 5 | ALA A 137ALA A 103GLY A 102GLY A 118ILE A 117 | None | 1.18A | 2v7bA-4mzuA:undetectable | 2v7bA-4mzuA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4npc | SORBITOLDEHYDROGENASE (Brucella suis) |
PF13561(adh_short_C2) | 5 | ALA A 162TYR A 163ALA A 152GLY A 153ILE A 157 | None | 1.13A | 2v7bA-4npcA:4.6 | 2v7bA-4npcA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nu2 | ANTIFREEZE PROTEIN (Flavobacteriumfrigoris) |
PF11999(DUF3494) | 5 | ALA A 261ALA A 95GLY A 94GLY A 80ILE A 98 | None | 1.23A | 2v7bA-4nu2A:undetectable | 2v7bA-4nu2A:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4olo | BMC DOMAIN PROTEIN (Clostridialesbacterium1_7_47FAA) |
PF00936(BMC) | 5 | ALA A 86ALA A 34GLY A 78GLY A 36ILE A 5 | None | 1.12A | 2v7bA-4oloA:undetectable | 2v7bA-4oloA:10.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pe6 | PUTATIVE ABCTRANSPORTER (Thermobisporabispora) |
PF13407(Peripla_BP_4) | 5 | PHE A 264ALA A 270TYR A 273ALA A 249GLY A 247 | None | 1.25A | 2v7bA-4pe6A:3.5 | 2v7bA-4pe6A:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rdc | AMINO ACID/AMIDE ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN, HAAT FAMILY (Trichormusvariabilis) |
PF13458(Peripla_BP_6) | 5 | PHE A 316ALA A 319TYR A 320ALA A 76GLY A 77 | NoneNoneGOL A 503 (-4.8A)GOL A 503 (-3.5A)None | 1.32A | 2v7bA-4rdcA:2.8 | 2v7bA-4rdcA:20.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4rlq | BENZOATE-COENZYME ALIGASE (Rhodopseudomonaspalustris) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 7 | ALA A 227TYR A 228ALA A 302GLY A 303GLY A 327HIS A 333ILE A 334 | 3SK A1000 (-3.6A)3SK A1000 (-4.8A)3SK A1000 ( 3.8A)3SK A1000 (-3.3A)3SK A1000 (-3.6A)3SK A1000 ( 4.1A)None | 0.31A | 2v7bA-4rlqA:62.0 | 2v7bA-4rlqA:61.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rxt | SUGAR ABCTRANSPORTER (Agrobacteriumtumefaciens) |
PF13407(Peripla_BP_4) | 5 | ALA A 229ALA A 203GLY A 205GLY A 210ILE A 213 | None | 0.86A | 2v7bA-4rxtA:4.6 | 2v7bA-4rxtA:20.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4wv3 | ANTHRANILATE-COALIGASE (Stigmatellaaurantiaca) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 6 | PHE A 220ALA A 293GLY A 318HIS A 324ILE A 325LYS A 506 | 3UK A 601 (-4.3A)3UK A 601 (-3.5A)3UK A 601 (-3.5A)3UK A 601 (-3.6A)None3UK A 601 (-2.5A) | 0.53A | 2v7bA-4wv3A:59.8 | 2v7bA-4wv3A:40.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zoh | PUTATIVEOXIDOREDUCTASEMOLYBDOPTERIN-BINDING SUBUNIT (Sulfurisphaeratokodaii) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | ALA A 334TYR A 331ALA A 162GLY A 253GLY A 216 | NoneNoneNoneNone MO A 802 ( 3.9A) | 0.84A | 2v7bA-4zohA:undetectable | 2v7bA-4zohA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zud | CHIMERA PROTEIN OFSOLUBLE CYTOCHROMEB562 AND TYPE-1ANGIOTENSIN IIRECEPTOR (Escherichiacoli;Homo sapiens) |
PF00001(7tm_1)PF07361(Cytochrom_B562) | 5 | PHE A 117ALA A 114TYR A 113ALA A 159GLY A 157 | None | 1.09A | 2v7bA-4zudA:undetectable | 2v7bA-4zudA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aov | GLYOXYLATE REDUCTASE (Pyrococcusfuriosus) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | ALA A 166ALA A 211GLY A 157GLY A 159ILE A 161 | NoneNoneNAP A1335 (-3.3A)NAP A1335 (-3.0A)NAP A1335 (-3.5A) | 1.23A | 2v7bA-5aovA:6.2 | 2v7bA-5aovA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dkx | ALPHAGLUCOSIDASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF17137(DUF5110) | 5 | ALA A 733ALA A 394GLY A 398GLY A 655ILE A 390 | None | 1.15A | 2v7bA-5dkxA:undetectable | 2v7bA-5dkxA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epo | 7-ALPHA-HYDROXYSTEROID DEYDROGENASE (Clostridiumsardiniense) |
PF13561(adh_short_C2) | 5 | ALA A 27GLY A 30GLY A 55ILE A 50LYS A 2 | None | 0.98A | 2v7bA-5epoA:5.0 | 2v7bA-5epoA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5esa | ANTI-HCV E2GLYCOPROTEIN FABHEAVY CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 5 | ALA A 61TYR A 60ALA A 58GLY A 50ILE A 70 | None | 1.15A | 2v7bA-5esaA:undetectable | 2v7bA-5esaA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fud | O-ACETYL-ADP-RIBOSEDEACETYLASE (Oceanobacillusiheyensis) |
PF01661(Macro) | 5 | ALA A 54ALA A 47GLY A 48GLY A 78ILE A 86 | None | 1.25A | 2v7bA-5fudA:2.1 | 2v7bA-5fudA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h05 | AMYP (marinemetagenome) |
PF00128(Alpha-amylase) | 5 | ALA A 352ALA A 260GLY A 264GLY A 308ILE A 310 | CA A 703 ( 4.9A)NoneNoneNoneNone | 1.09A | 2v7bA-5h05A:undetectable | 2v7bA-5h05A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i84 | PHOSPHATE-BINDINGPROTEIN PSTS (Xanthomonascitri) |
PF12849(PBP_like_2) | 5 | ALA A 189ALA A 81GLY A 164GLY A 63ILE A 66 | NoneNoneNonePO4 A 403 ( 3.1A)PO4 A 404 (-4.2A) | 1.22A | 2v7bA-5i84A:undetectable | 2v7bA-5i84A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iuf | BIFUNCTIONALOLIGORIBONUCLEASEAND PAP PHOSPHATASENRNA (Bacillussubtilis) |
PF01368(DHH)PF02272(DHHA1) | 5 | ALA A 146TYR A 150ALA A 173GLY A 174ILE A 153 | None | 1.21A | 2v7bA-5iufA:undetectable | 2v7bA-5iufA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iuy | MULTIDRUG EFFLUXOUTER MEMBRANEPROTEIN OPRN (Pseudomonasaeruginosa) |
PF02321(OEP) | 5 | ALA A 88ALA A 303GLY A 304GLY A 306ILE A 309 | None | 0.93A | 2v7bA-5iuyA:undetectable | 2v7bA-5iuyA:25.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kia | L-THREONINE3-DEHYDROGENASE (Burkholderiathailandensis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 145TYR A 65ALA A 120GLY A 62ILE A 32 | None | 1.03A | 2v7bA-5kiaA:undetectable | 2v7bA-5kiaA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lpc | VANADIUM-DEPENDENTBROMOPEROXIDASE (Acaryochlorismarina) |
no annotation | 5 | ALA A 518ALA A 524GLY A 525HIS A 520ILE A 584 | PO4 A 901 ( 4.3A)NoneNonePO4 A 901 (-4.1A)None | 1.21A | 2v7bA-5lpcA:undetectable | 2v7bA-5lpcA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mq6 | PYRIDINENUCLEOTIDE-DISULFIDEOXIDOREDUCTASE-LIKEPROTEIN (Thermothelomycesthermophila) |
PF07992(Pyr_redox_2) | 5 | ALA A 94TYR A 93ALA A 222GLY A 85GLY A 89 | NoneNoneFAD A 700 (-4.8A)FAD A 700 (-3.6A)FAD A 700 (-3.4A) | 1.31A | 2v7bA-5mq6A:undetectable | 2v7bA-5mq6A:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5msc | CARBOXYLIC ACIDREDUCTASE (Nocardiaiowensis) |
PF00501(AMP-binding) | 5 | ALA A 134ALA A 102GLY A 231GLY A 98HIS A 137 | None | 1.35A | 2v7bA-5mscA:34.1 | 2v7bA-5mscA:20.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5oe5 | ANTHRANILATE--COALIGASE (Pseudomonasaeruginosa) |
PF00501(AMP-binding) | 6 | PHE A 209TYR A 211ALA A 278GLY A 279GLY A 302HIS A 308 | 3UK A 900 (-4.2A)3UK A 900 (-4.0A)3UK A 900 ( 2.9A)3UK A 900 (-3.2A)3UK A 900 (-3.4A)3UK A 900 ( 2.8A) | 0.30A | 2v7bA-5oe5A:50.9 | 2v7bA-5oe5A:30.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5u2a | AMP-DEPENDENTSYNTHETASE ANDLIGASE (Brucella canis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | ALA A 250TYR A 251ALA A 322GLY A 323GLY A 347 | None | 0.68A | 2v7bA-5u2aA:44.8 | 2v7bA-5u2aA:34.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uf2 | RIBOSE-5-PHOSPHATEISOMERASE A (Neisseriagonorrhoeae) |
PF06026(Rib_5-P_isom_A) | 5 | PHE A 114ALA A 108GLY A 83GLY A 28ILE A 27 | NoneBTB A 303 (-3.9A)EDO A 306 (-3.2A)NoneNone | 1.15A | 2v7bA-5uf2A:undetectable | 2v7bA-5uf2A:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ufh | LACI-TYPETRANSCRIPTIONALREGULATOR (Bifidobacteriumanimalis) |
PF13377(Peripla_BP_3) | 5 | ALA A 68ALA A 119GLY A 121GLY A 66ILE A 96 | None | 1.31A | 2v7bA-5ufhA:5.0 | 2v7bA-5ufhA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5usc | PREPHENATEDEHYDROGENASE (Bacillusanthracis) |
PF02153(PDH) | 5 | ALA A 30ALA A 80GLY A 21GLY A 23ILE A 25 | None | 1.26A | 2v7bA-5uscA:6.0 | 2v7bA-5uscA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ux9 | CHLORAMPHENICOLACETYLTRANSFERASE (Aliivibriofischeri) |
PF00132(Hexapep) | 5 | ALA A 149ALA A 80GLY A 79GLY A 128ILE A 127 | None | 1.05A | 2v7bA-5ux9A:undetectable | 2v7bA-5ux9A:17.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vip | MDCE (Pseudomonasaeruginosa) |
PF06833(MdcE) | 5 | ALA A 144ALA A 114GLY A 68GLY A 64ILE A 111 | None | 1.20A | 2v7bA-5vipA:undetectable | 2v7bA-5vipA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wa3 | PYRIDINE SYNTHASETBTD (Thermobisporabispora) |
no annotation | 5 | PHE A 308ALA A 307TYR A 311ALA A 184GLY A 179 | None | 1.08A | 2v7bA-5wa3A:undetectable | 2v7bA-5wa3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wl2 | - (-) |
no annotation | 5 | ALA H 61TYR H 60ALA H 58GLY H 50ILE H 70 | None | 1.21A | 2v7bA-5wl2H:undetectable | 2v7bA-5wl2H:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x4j | UNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
no annotation | 5 | ALA A 83ALA A 162GLY A 161GLY A 138HIS A 106 | ZN A 501 ( 4.8A)NoneNoneNone ZN A 501 (-3.3A) | 1.27A | 2v7bA-5x4jA:2.7 | 2v7bA-5x4jA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y2w | RUBISCO OPERONTRANSCRIPTIONALREGULATOR (Synechocystissp. PCC 6803) |
no annotation | 5 | ALA A 170ALA A 231GLY A 234GLY A 237ILE A 193 | None | 1.04A | 2v7bA-5y2wA:undetectable | 2v7bA-5y2wA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yy3 | - (-) |
no annotation | 5 | PHE A 383ALA A 377ALA A 354GLY A 351ILE A 372 | None | 1.29A | 2v7bA-5yy3A:undetectable | 2v7bA-5yy3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6apx | MALTOSE-BINDINGPERIPLASMICPROTEIN,DUALSPECIFICITY PROTEINPHOSPHATASE 1 (Escherichiacoli;Homo sapiens) |
no annotation | 5 | ALA A1186TYR A1187ALA A 370GLY A1172ILE A 178 | NoneNoneSO4 A1401 ( 3.9A)SO4 A1401 (-3.3A)None | 1.21A | 2v7bA-6apxA:2.5 | 2v7bA-6apxA:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bii | GLYOXYLATE REDUCTASE (Pyrococcusyayanosii) |
no annotation | 5 | ALA A 166ALA A 211GLY A 157GLY A 159ILE A 161 | NoneNoneNAP A 401 (-3.4A)NAP A 401 (-3.3A)NAP A 401 (-3.7A) | 1.28A | 2v7bA-6biiA:6.2 | 2v7bA-6biiA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d0n | CLC-TYPEFLUORIDE/PROTONANTIPORTER (Enterococcuscasseliflavus) |
no annotation | 5 | ALA A 164ALA A 188GLY A 25GLY A 149ILE A 148 | None | 1.29A | 2v7bA-6d0nA:undetectable | 2v7bA-6d0nA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6epd | PROTEASOME SUBUNITBETA TYPE-4 (Rattusnorvegicus) |
no annotation | 5 | ALA 7 68ALA 7 97GLY 7 96GLY 7 157ILE 7 156 | None | 1.28A | 2v7bA-6epd7:undetectable | 2v7bA-6epd7:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6epd | PROTEASOME SUBUNITBETA TYPE-4 (Rattusnorvegicus) |
no annotation | 5 | ALA 7 68ALA 7 97GLY 7 96GLY 7 158ILE 7 156 | None | 1.16A | 2v7bA-6epd7:undetectable | 2v7bA-6epd7:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6esq | HYDROXYMETHYLGLUTARYL-COA SYNTHASE (Methanothermococcusthermolithotrophicus) |
no annotation | 5 | ALA I 144ALA I 141GLY I 140GLY I 159ILE I 55 | None | 1.26A | 2v7bA-6esqI:undetectable | 2v7bA-6esqI:undetectable |