SIMILAR PATTERNS OF AMINO ACIDS FOR 2V3K_A_SAMA1254_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 107
GLY A 105
GLY A 192
LEU A 244
ALA A 177
 None
 0.97A 2v3kA-1e5mA:
undetectable		 2v3kA-1e5mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia5 POLYGALACTURONASE

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		5 GLY A 201
ASP A 231
GLY A 263
LEU A 256
SER A 294
 None
 0.97A 2v3kA-1ia5A:
undetectable		 2v3kA-1ia5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II

(Thermus
thermophilus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 101
GLY A  99
GLY A 186
LEU A 238
ALA A 171
 None
 0.91A 2v3kA-1j3nA:
undetectable		 2v3kA-1j3nA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Haemophilus
influenzae) 		PF08282
(Hydrolase_3) 		5 VAL A  18
GLY A  17
LEU A 139
SER A 140
ALA A 147
 None
CO  A 201 ( 4.4A)
None
None
None
 0.97A 2v3kA-1k1eA:
4.0		 2v3kA-1k1eA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ns5 HYPOTHETICAL PROTEIN
YBEA

(Escherichia
coli) 		PF02590
(SPOUT_MTase) 		5 LEU A  72
GLY A 103
LEU A 122
SER A 123
LEU A 127
 None
 0.64A 2v3kA-1ns5A:
7.5		 2v3kA-1ns5A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxz HYPOTHETICAL PROTEIN
HI0303

(Haemophilus
influenzae) 		PF04452
(Methyltrans_RNA) 		5 LEU A 171
GLY A 195
LEU A 218
LEU A 223
ALA A 228
 None
 0.96A 2v3kA-1nxzA:
7.6		 2v3kA-1nxzA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjw ALCOHOL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A  64
GLY A  65
LEU A 296
LEU A 138
ALA A 143
 None
 0.96A 2v3kA-1rjwA:
undetectable		 2v3kA-1rjwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		5 VAL A  31
GLY A  30
GLY A  79
LEU A 232
ALA A 231
 None
 1.00A 2v3kA-1s2nA:
undetectable		 2v3kA-1s2nA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sml PROTEIN
(PENICILLINASE)

(Stenotrophomonas
maltophilia) 		PF00753
(Lactamase_B) 		5 LEU A 114
GLY A 117
LEU A  82
SER A  83
ALA A  90
 None
 0.93A 2v3kA-1smlA:
undetectable		 2v3kA-1smlA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sml PROTEIN
(PENICILLINASE)

(Stenotrophomonas
maltophilia) 		PF00753
(Lactamase_B) 		5 LEU A 114
GLY A 118
LEU A  82
SER A  83
ALA A  90
 None
 0.97A 2v3kA-1smlA:
undetectable		 2v3kA-1smlA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tig TRANSLATION
INITIATION FACTOR 3

(Geobacillus
stearothermophilus) 		PF00707
(IF3_C) 		5 LEU A  90
LEU A 140
SER A 141
LEU A 163
ALA A 118
 None
 0.90A 2v3kA-1tigA:
undetectable		 2v3kA-1tigA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)

(Escherichia
coli) 		PF01408
(GFO_IDH_MocA) 		5 LEU A  85
VAL A  90
GLY A  89
LEU A  59
ALA A  63
 None
 0.87A 2v3kA-1tltA:
undetectable		 2v3kA-1tltA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 LEU B 340
VAL B  10
GLY B   9
GLY B 337
LEU B 333
SER B 335
 None
 1.44A 2v3kA-1tqyB:
undetectable		 2v3kA-1tqyB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6z HYPOTHETICAL PROTEIN
TTHA0657

(Thermus
thermophilus) 		PF04452
(Methyltrans_RNA) 		5 VAL A 180
GLY A 181
LEU A 204
LEU A 209
ALA A 214
 None
 0.63A 2v3kA-1v6zA:
7.7		 2v3kA-1v6zA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		5 GLY A 204
GLY A 226
LEU A 227
LEU A 232
ALA A 237
 None
 0.51A 2v3kA-1vhkA:
8.8		 2v3kA-1vhkA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wr6 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3

(Homo sapiens) 		PF03127
(GAT) 		5 LEU A 280
GLY A 277
LEU A 276
SER A 275
ALA A 266
 None
 0.93A 2v3kA-1wr6A:
undetectable		 2v3kA-1wr6A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7p RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00588
(SpoU_methylase) 		5 LEU A 155
VAL A 129
GLY A 128
SER A 176
ALA A 147
 None
 0.98A 2v3kA-1x7pA:
9.6		 2v3kA-1x7pA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd8 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3

(Homo sapiens) 		PF03127
(GAT) 		5 LEU G 280
GLY G 277
LEU G 276
SER G 275
ALA G 266
 None
 0.99A 2v3kA-1yd8G:
undetectable		 2v3kA-1yd8G:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		5 VAL A  68
ASP A  28
LEU A  51
LEU A  48
ALA A  79
 None
 0.98A 2v3kA-1yt8A:
undetectable		 2v3kA-1yt8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN

(Ovis aries) 		PF00230
(MIP) 		6 PHE A  26
GLY A  96
GLY A  27
LEU A  28
LEU A 104
ALA A 101
 None
 1.32A 2v3kA-2b6oA:
undetectable		 2v3kA-2b6oA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 LEU A 319
VAL A 323
GLY A 322
GLY A 317
LEU A 304
 None
 0.76A 2v3kA-2douA:
undetectable		 2v3kA-2douA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus) 		PF04452
(Methyltrans_RNA) 		6 LEU A 161
VAL A 184
GLY A 185
LEU A 208
LEU A 213
ALA A 218
 SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 3.6A)
 0.62A 2v3kA-2egwA:
7.1		 2v3kA-2egwA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE

(Aquifex
aeolicus) 		PF02441
(Flavoprotein) 		5 LEU A 121
VAL A  85
GLY A  84
LEU A 115
ALA A 114
 None
 0.85A 2v3kA-2ejbA:
undetectable		 2v3kA-2ejbA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 283
VAL A 288
GLY A 287
GLY A 280
LEU A 281
 None
None
None
None
FAD  A8482 (-4.7A)
 0.94A 2v3kA-2eq9A:
2.2		 2v3kA-2eq9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5x RIBOSOME-INACTIVATIN
G PROTEIN

(Silene
chalcedonica) 		PF00161
(RIP) 		5 LEU A  61
PHE A  45
VAL A  48
GLY A  72
LEU A  70
 None
 0.92A 2v3kA-2g5xA:
undetectable		 2v3kA-2g5xA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hig 6-PHOSPHO-1-FRUCTOKI
NASE

(Trypanosoma
brucei) 		PF00365
(PFK) 		5 LEU A 185
VAL A 190
GLY A 189
LEU A 142
SER A 143
 None
 0.97A 2v3kA-2higA:
undetectable		 2v3kA-2higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A 487
GLY A 462
ASP A 409
LEU A 473
SER A 471
 None
TPP  A 600 (-3.4A)
None
None
None
 0.90A 2v3kA-2ihtA:
undetectable		 2v3kA-2ihtA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8s AGR_C_984P

(Agrobacterium
fabrum) 		PF06748
(DUF1217) 		5 LEU A 200
VAL A 196
GLY A 195
LEU A 185
ALA A 189
 None
 0.93A 2v3kA-2o8sA:
undetectable		 2v3kA-2o8sA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q09 IMIDAZOLONEPROPIONAS
E

(unidentified) 		PF01979
(Amidohydro_1) 		5 LEU A 277
VAL A 282
GLY A 281
GLY A 273
ALA A 256
 None
 0.97A 2v3kA-2q09A:
undetectable		 2v3kA-2q09A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmm UPF0217 PROTEIN
AF_1056

(Archaeoglobus
fulgidus) 		PF04013
(Methyltrn_RNA_2) 		5 LEU A 221
GLY A 242
LEU A 265
SER A 266
LEU A 270
 SAM  A 301 (-4.3A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.4A)
SAM  A 301 (-4.2A)
SAM  A 301 (-4.5A)
 0.54A 2v3kA-2qmmA:
14.7		 2v3kA-2qmmA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 5 LEU A 586
VAL A 600
GLY A 599
ASP A 585
LEU A 588
 None
 0.90A 2v3kA-2quaA:
undetectable		 2v3kA-2quaA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz6 BETA-LACTAMASE

(Pseudomonas
fluorescens) 		PF00144
(Beta-lactamase) 		5 LEU A 157
GLY A 159
LEU A 161
LEU A 106
ALA A  89
 None
 0.99A 2v3kA-2qz6A:
undetectable		 2v3kA-2qz6A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkb SERINE
DEHYDRATASE-LIKE

(Homo sapiens) 		PF00291
(PALP) 		5 LEU A 179
VAL A 173
GLY A 174
GLY A 181
ALA A 238
 None
PLP  A 400 ( 4.1A)
PLP  A 400 ( 3.3A)
None
None
 0.97A 2v3kA-2rkbA:
undetectable		 2v3kA-2rkbA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF03308
(ArgK) 		5 LEU A 240
VAL A 176
GLY A 147
LEU A 148
SER A 149
 None
 0.93A 2v3kA-2wwwA:
undetectable		 2v3kA-2wwwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrm INTRACELLULAR
SUBTILISIN PROTEASE

(Bacillus
clausii) 		PF00082
(Peptidase_S8) 		6 VAL A  25
GLY A  24
GLY A 258
LEU A 262
LEU A 305
ALA A  30
 None
 1.30A 2v3kA-2xrmA:
undetectable		 2v3kA-2xrmA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu CROSSOVER JUNCTION
ENDONUCLEASE EME1

(Homo sapiens) 		PF02732
(ERCC4) 		5 LEU B 269
GLY B 271
LEU B 432
SER B 428
ALA B 433
 None
 0.84A 2v3kA-2ziuB:
undetectable		 2v3kA-2ziuB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a68 FERRITIN-4,
CHLOROPLASTIC

(Glycine max) 		PF00210
(Ferritin) 		5 VAL A 197
GLY A 194
GLY A  79
LEU A  80
ALA A 129
 None
 0.97A 2v3kA-3a68A:
undetectable		 2v3kA-3a68A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350

(Thermus
thermophilus) 		PF00582
(Usp) 		5 LEU A 208
VAL A 213
GLY A 212
LEU A 171
ALA A 175
 LEU  A 208 ( 0.6A)
VAL  A 213 ( 0.6A)
GLY  A 212 ( 0.0A)
LEU  A 171 ( 0.6A)
ALA  A 175 ( 0.0A)
 0.98A 2v3kA-3ab7A:
undetectable		 2v3kA-3ab7A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococcus
jannaschii) 		PF04013
(Methyltrn_RNA_2) 		5 LEU X 136
GLY X 156
LEU X 179
SER X 180
LEU X 184
 SAM  X 501 (-4.3A)
SAM  X 501 (-3.2A)
SAM  X 501 (-4.4A)
SAM  X 501 (-4.2A)
SAM  X 501 (-4.3A)
 0.46A 2v3kA-3ai9X:
14.0		 2v3kA-3ai9X:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		5 LEU A 172
VAL A 435
GLY A 436
GLY A 139
SER A 118
 None
 0.93A 2v3kA-3al0A:
undetectable		 2v3kA-3al0A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N) 		6 LEU A 395
GLY A  69
GLY A 391
LEU A 390
LEU A 389
ALA A 113
 None
 1.47A 2v3kA-3d4jA:
undetectable		 2v3kA-3d4jA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwz BETA-LACTAMASE

(Mycobacterium
tuberculosis) 		PF13354
(Beta-lactamase2) 		6 VAL A 302
GLY A  60
LEU A  59
SER A 279
LEU A 295
ALA A 298
 None
 1.39A 2v3kA-3dwzA:
undetectable		 2v3kA-3dwzA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 110
GLY A 108
GLY A 195
LEU A 248
ALA A 180
 None
 0.98A 2v3kA-3e60A:
undetectable		 2v3kA-3e60A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe1 HEAT SHOCK 70 KDA
PROTEIN 6

(Homo sapiens) 		PF00012
(HSP70) 		5 LEU A 255
GLY A 257
LEU A 289
SER A 288
ALA A 261
 None
 0.93A 2v3kA-3fe1A:
undetectable		 2v3kA-3fe1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvw PUTATIVE
NAD(P)H-DEPENDENT
FMN REDUCTASE

(Streptococcus
mutans) 		PF03358
(FMN_red) 		6 LEU A  89
PHE A  46
VAL A  86
GLY A  84
LEU A  93
SER A  94
 None
 1.29A 2v3kA-3fvwA:
undetectable		 2v3kA-3fvwA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8q PREDICTED
RNA-BINDING PROTEIN,
CONTAINS THUMP
DOMAIN

(Methanopyrus
kandleri) 		PF00383
(dCMP_cyt_deam_1)
PF02926
(THUMP) 		5 LEU A  96
VAL A 101
GLY A 100
GLY A  92
ALA A  75
 None
 0.89A 2v3kA-3g8qA:
undetectable		 2v3kA-3g8qA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		5 LEU A 144
VAL A  77
LEU A  62
SER A  59
ALA A  91
 None
None
None
SAM  A4633 ( 4.9A)
None
 0.95A 2v3kA-3gczA:
undetectable		 2v3kA-3gczA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gra TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY

(Pseudomonas
putida) 		PF01965
(DJ-1_PfpI) 		5 LEU A 138
VAL A 143
GLY A 142
GLY A 134
LEU A 114
 None
 0.65A 2v3kA-3graA:
2.8		 2v3kA-3graA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2v ADENYLYLTRANSFERASE
AND
SULFURTRANSFERASE
MOCS3

(Homo sapiens) 		PF00581
(Rhodanese) 		5 VAL A  76
ASP A  21
LEU A  44
LEU A  41
ALA A  87
 None
 0.96A 2v3kA-3i2vA:
undetectable		 2v3kA-3i2vA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 110
GLY A 108
GLY A 195
LEU A 248
ALA A 180
 None
 1.00A 2v3kA-3kzuA:
undetectable		 2v3kA-3kzuA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l76 ASPARTOKINASE

(Synechocystis
sp. PCC 6803) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		5 LEU A 379
VAL A 384
GLY A 383
LEU A 412
ALA A 408
 None
 0.96A 2v3kA-3l76A:
undetectable		 2v3kA-3l76A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9i LENS FIBER MAJOR
INTRINSIC PROTEIN

(Ovis aries) 		PF00230
(MIP) 		6 PHE A  26
GLY A  96
GLY A  27
LEU A  28
LEU A 104
ALA A 101
 None
 1.27A 2v3kA-3m9iA:
undetectable		 2v3kA-3m9iA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mah ASPARTOKINASE

(Porphyromonas
gingivalis) 		PF13840
(ACT_7) 		6 LEU A 401
VAL A 404
GLY A 403
LEU A 434
SER A 435
ALA A 430
 None
 1.35A 2v3kA-3mahA:
undetectable		 2v3kA-3mahA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkh NITROALKANE OXIDASE

(Podospora
anserina) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A 272
GLY A 341
SER A 424
LEU A 351
ALA A 334
 None
 0.92A 2v3kA-3mkhA:
undetectable		 2v3kA-3mkhA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1h PERIPLASMIC PROTEIN
TORT

(Vibrio
parahaemolyticus) 		PF00532
(Peripla_BP_1) 		5 GLY B 225
GLY B 260
LEU B 261
LEU B 253
ALA B 269
 None
 0.92A 2v3kA-3o1hB:
3.2		 2v3kA-3o1hB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		5 LEU B 287
VAL B 292
GLY B 291
GLY B 283
LEU B 239
 None
 0.84A 2v3kA-3o8oB:
undetectable		 2v3kA-3o8oB:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 6 LEU N 214
PHE N 216
VAL N 254
GLY N 213
LEU N 170
SER N 167
 None
 1.43A 2v3kA-3rkoN:
undetectable		 2v3kA-3rkoN:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8d COENZYME A
TRANSFERASE

(Yersinia pestis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 LEU A 244
VAL A 263
GLY A 262
LEU A 223
LEU A 255
 None
 0.68A 2v3kA-3s8dA:
undetectable		 2v3kA-3s8dA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sju KETO REDUCTASE

(Streptomyces
griseoruber) 		PF00106
(adh_short) 		5 GLY A  57
GLY A  17
LEU A  18
SER A  14
ALA A  44
 None
None
None
NDP  A 301 (-3.0A)
None
 0.90A 2v3kA-3sjuA:
undetectable		 2v3kA-3sjuA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR

(Arabidopsis
thaliana) 		PF05147
(LANC_like) 		5 LEU A  75
GLY A 124
GLY A  81
LEU A 383
SER A 382
 None
 1.00A 2v3kA-3t33A:
undetectable		 2v3kA-3t33A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		6 LEU A 390
VAL A 429
ASP A 391
LEU A 414
LEU A 411
ALA A 440
 None
 1.27A 2v3kA-3tp9A:
undetectable		 2v3kA-3tp9A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uj2 ENOLASE 1

(Anaerostipes
caccae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 VAL A  33
GLY A  32
SER A  87
LEU A   4
ALA A 127
 None
 0.85A 2v3kA-3uj2A:
undetectable		 2v3kA-3uj2A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6k SCPB

(Geobacillus
stearothermophilus) 		PF04079
(SMC_ScpB) 		5 LEU B  77
PHE B  26
VAL B  70
GLY B  29
ALA B  79
 None
 1.00A 2v3kA-3w6kB:
undetectable		 2v3kA-3w6kB:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b29 DIMETHYLSULFONIOPROP
IONATE LYASE

(Roseovarius
nubinhibens) 		PF16867
(DMSP_lyase) 		5 LEU A 180
VAL A 115
GLY A 116
LEU A  64
SER A  61
 None
None
EDO  A1201 ( 3.8A)
None
None
 0.98A 2v3kA-4b29A:
undetectable		 2v3kA-4b29A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dna PROBABLE GLUTATHIONE
REDUCTASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 275
VAL A 280
GLY A 279
GLY A 272
LEU A 273
 None
None
None
None
FAD  A 500 (-4.3A)
 0.91A 2v3kA-4dnaA:
undetectable		 2v3kA-4dnaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE

(Homo sapiens) 		PF00291
(PALP) 		5 LEU A 173
VAL A 167
GLY A 168
GLY A 175
ALA A 232
 None
LLP  A  41 ( 4.1A)
LLP  A  41 ( 3.5A)
None
None
 0.94A 2v3kA-4h27A:
undetectable		 2v3kA-4h27A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h43 27.5 KDA VIRULENCE
PROTEIN

(Salmonella
enterica) 		PF03536
(VRP3) 		6 LEU A 187
VAL A 192
GLY A 191
LEU A 121
SER A 122
ALA A 117
 None
 1.09A 2v3kA-4h43A:
undetectable		 2v3kA-4h43A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01746
(tRNA_m1G_MT) 		5 LEU A 186
VAL A 205
GLY A 206
LEU A 232
LEU A 246
 SAH  A 302 (-4.2A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.1A)
SAH  A 302 (-3.8A)
SAH  A 302 (-4.2A)
 0.71A 2v3kA-4jwjA:
7.0		 2v3kA-4jwjA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k22 PROTEIN VISC

(Escherichia
coli) 		PF01494
(FAD_binding_3) 		5 LEU A 284
GLY A 327
GLY A 162
LEU A 286
ALA A 280
 None
 1.00A 2v3kA-4k22A:
undetectable		 2v3kA-4k22A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Mycobacterium
tuberculosis) 		PF04452
(Methyltrans_RNA) 		5 LEU A 175
VAL A 198
GLY A 199
LEU A 222
ALA A 232
 None
 0.59A 2v3kA-4l69A:
8.1		 2v3kA-4l69A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8d PUTATIVE
UNCHARACTERIZED
PROTEIN

(Labrenzia
aggregata) 		PF04199
(Cyclase) 		5 VAL A 188
GLY A 142
GLY A 191
LEU A 223
LEU A 239
 None
 0.92A 2v3kA-4m8dA:
undetectable		 2v3kA-4m8dA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nef AQUAPORIN-2

(Homo sapiens) 		PF00230
(MIP) 		6 PHE A  26
GLY A  96
GLY A  27
LEU A  28
LEU A 104
ALA A 101
 None
 1.21A 2v3kA-4nefA:
undetectable		 2v3kA-4nefA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4noc PUTATIVE SIGNAL
TRANSDUCTION PROTEIN
WITH CBS DOMAINS

(Kribbella
flavida) 		PF00571
(CBS) 		6 LEU A  47
VAL A  88
GLY A  33
LEU A  26
LEU A  25
ALA A  22
 None
 1.36A 2v3kA-4nocA:
undetectable		 2v3kA-4nocA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0r CROSSOVER JUNCTION
ENDONUCLEASE EME1

(Homo sapiens) 		PF02732
(ERCC4) 		5 LEU B 269
GLY B 271
LEU B 432
SER B 428
ALA B 433
 None
 0.85A 2v3kA-4p0rB:
undetectable		 2v3kA-4p0rB:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE

(Plasmodium
vivax) 		PF00082
(Peptidase_S8) 		5 LEU A 526
VAL A 500
GLY A 596
LEU A 503
ALA A 528
 None
 1.00A 2v3kA-4tr2A:
undetectable		 2v3kA-4tr2A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE

(Pseudomonas sp.) 		PF00202
(Aminotran_3) 		6 LEU A 444
VAL A 447
GLY A 446
LEU A 420
LEU A 406
ALA A 402
 None
 1.48A 2v3kA-4uhmA:
undetectable		 2v3kA-4uhmA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs ECU04_1440 PROTEIN

(Encephalitozoon
cuniculi) 		PF00352
(TBP) 		5 GLY D 105
GLY D  77
LEU D  34
SER D  35
ALA D 108
 None
 0.89A 2v3kA-4wzsD:
undetectable		 2v3kA-4wzsD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmr PUTATIVE
METHYL-ACCEPTING
CHEMOTAXIS SIGNAL
TRANSDUCTION PROTEIN

(Campylobacter
jejuni) 		PF02743
(dCache_1) 		6 LEU A 119
VAL A 101
GLY A 102
GLY A 120
LEU A 121
LEU A 140
 None
 1.25A 2v3kA-4xmrA:
undetectable		 2v3kA-4xmrA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ziu UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF07678
(A2M_comp) 		6 LEU A1649
VAL A1626
ASP A1035
GLY A1554
LEU A1555
LEU A1551
 None
 1.31A 2v3kA-4ziuA:
undetectable		 2v3kA-4ziuA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 LEU A 421
GLY A 417
LEU A 425
LEU A  83
ALA A  79
 None
 0.98A 2v3kA-5a5gA:
undetectable		 2v3kA-5a5gA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		5 LEU A  77
VAL A 126
LEU A  81
SER A  82
ALA A 136
 None
 0.99A 2v3kA-5bp8A:
undetectable		 2v3kA-5bp8A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5x AQUAPORIN-5

(Homo sapiens) 		PF00230
(MIP) 		6 PHE A  27
GLY A  97
GLY A  28
LEU A  29
LEU A 105
ALA A 102
 None
 1.27A 2v3kA-5c5xA:
undetectable		 2v3kA-5c5xA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8a LIGHT-DEPENDENT
TRANSCRIPTIONAL
REGULATOR CARH

(Thermus
thermophilus) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		5 LEU A 188
VAL A 193
GLY A 192
LEU A 270
ALA A 271
 None
None
None
B12  A 300 ( 4.4A)
None
 0.81A 2v3kA-5c8aA:
undetectable		 2v3kA-5c8aA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czj DIHYDRODIPICOLINATE
SYNTHASE

(Sinorhizobium
meliloti) 		PF00701
(DHDPS) 		5 LEU A  87
VAL A  92
GLY A  91
GLY A  83
LEU A  48
 None
 0.84A 2v3kA-5czjA:
undetectable		 2v3kA-5czjA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d5p HCGB

(Methanococcus
maripaludis) 		PF11576
(DUF3236) 		5 LEU A 112
GLY A 110
GLY A 125
LEU A 114
ALA A  82
 None
 0.99A 2v3kA-5d5pA:
undetectable		 2v3kA-5d5pA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		6 LEU A 358
VAL A 267
GLY A 266
GLY A 357
LEU A 310
ALA A 313
 None
 1.48A 2v3kA-5dmhA:
3.1		 2v3kA-5dmhA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo6 COPROPORPHYRINOGEN
OXIDASE

(Acinetobacter
baumannii) 		PF01218
(Coprogen_oxidas) 		5 LEU A 199
PHE A 121
GLY A 136
ASP A 197
LEU A 120
 None
 0.93A 2v3kA-5eo6A:
undetectable		 2v3kA-5eo6A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evl BETA-LACTAMASE

(Chromobacterium
violaceum) 		PF00144
(Beta-lactamase) 		5 LEU A 158
GLY A 160
LEU A 162
LEU A 107
ALA A  90
 None
 0.97A 2v3kA-5evlA:
undetectable		 2v3kA-5evlA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey0 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Staphylococcus
aureus) 		no annotation 5 LEU B 224
VAL B 229
GLY B 228
LEU B 179
ALA B 175
 None
 0.93A 2v3kA-5ey0B:
undetectable		 2v3kA-5ey0B:
20.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1

(Homo sapiens) 		PF03587
(EMG1) 		5 PHE A 178
VAL A 200
GLY A 201
SER A 220
LEU A 224
 None
SAH  A 301 (-3.5A)
SAH  A 301 (-3.2A)
SAH  A 301 (-4.5A)
SAH  A 301 (-4.0A)
 0.35A 2v3kA-5faiA:
29.6		 2v3kA-5faiA:
50.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj3 PERIPLASMIC BINDING
PROTEIN

(Roseiflexus sp.
RS-1) 		PF01497
(Peripla_BP_2) 		5 PHE A 237
GLY A 264
GLY A 250
LEU A 236
ALA A 267
 None
 0.92A 2v3kA-5gj3A:
undetectable		 2v3kA-5gj3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens;
Homo sapiens) 		no annotation
PF04858
(TH1) 		5 LEU B 213
VAL A 128
GLY A 129
GLY B 216
ALA B 257
 None
 0.95A 2v3kA-5l3xB:
undetectable		 2v3kA-5l3xB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loe GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Bacillus
subtilis) 		PF06018
(CodY)
PF08222
(HTH_CodY) 		5 LEU A 224
VAL A 229
GLY A 228
LEU A 179
ALA A 175
 None
 0.94A 2v3kA-5loeA:
undetectable		 2v3kA-5loeA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t09 TYPE III SECRETION
SYSTEM EFFECTOR
HOPBA1

(Pseudomonas
syringae) 		no annotation 5 LEU A  72
VAL A  77
GLY A  76
LEU A  40
ALA A  44
 None
 0.97A 2v3kA-5t09A:
undetectable		 2v3kA-5t09A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0g PROTEASOME SUBUNIT
BETA TYPE-5

(Homo sapiens) 		PF00227
(Proteasome) 		5 VAL R 138
GLY R 137
ASP R 140
LEU R   4
ALA R 159
 None
 0.91A 2v3kA-5t0gR:
undetectable		 2v3kA-5t0gR:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tky PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 LEU A 257
GLY A 259
LEU A 291
SER A 290
ALA A 263
 None
 0.71A 2v3kA-5tkyA:
undetectable		 2v3kA-5tkyA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		PF13281
(DUF4071) 		6 LEU A 429
GLY A 479
GLY A 432
LEU A 459
LEU A 487
ALA A 484
 None
 1.35A 2v3kA-5ulmA:
undetectable		 2v3kA-5ulmA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF04084
(ORC2)
no annotation 		5 VAL B 319
GLY B 320
ASP B 457
GLY C 595
LEU C 596
 None
 0.96A 2v3kA-5v8fB:
undetectable		 2v3kA-5v8fB:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 5 VAL A 115
GLY A 114
GLY A  22
LEU A  24
LEU A 108
 None
 0.98A 2v3kA-6bfiA:
undetectable		 2v3kA-6bfiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY

(Brevundimonas
sp. BAL3) 		no annotation 5 ASP A 247
GLY A 274
SER A 272
LEU A 296
ALA A 301
 None
 0.97A 2v3kA-6frlA:
undetectable		 2v3kA-6frlA:
undetectable