SIMILAR PATTERNS OF AMINO ACIDS FOR 2V3D_B_NBVB1504

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqc PROTEIN
(BETA-MANNANASE)

(Thermobifida
fusca) 		PF00150
(Cellulase) 		5 ASN A 127
GLU A 128
TYR A 198
GLU A 225
TRP A 254
 None
 0.75A 2v3dB-1bqcA:
4.1		 2v3dB-1bqcA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		5 ASN A 182
GLU A 183
TYR A 326
GLU A 397
TRP A 446
 None
 0.80A 2v3dB-1cbgA:
2.5		 2v3dB-1cbgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus) 		PF00150
(Cellulase) 		5 ASN A 161
GLU A 162
TYR A 240
GLU A 282
TRP A 319
 BGC  A 403 (-3.5A)
BGC  A 402 ( 2.5A)
BGC  A 402 ( 4.7A)
BGC  A 403 (-2.8A)
BGC  A 403 ( 4.2A)
 0.83A 2v3dB-1eceA:
11.5		 2v3dB-1eceA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqc EXO-(B)-(1,3)-GLUCAN
ASE

(Candida
albicans) 		PF00150
(Cellulase) 		5 ASN A 191
GLU A 192
TYR A 255
GLU A 292
TRP A 363
 CTS  A 401 (-3.1A)
CTS  A 401 (-3.3A)
CTS  A 401 (-3.7A)
CTS  A 401 (-2.8A)
CTS  A 401 (-3.5A)
 0.77A 2v3dB-1eqcA:
13.9		 2v3dB-1eqcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		6 ASP A 201
ASN A 460
TYR A 503
GLU A 537
TRP A 568
ASN A 102
 None
None
None
None
None
MG  A3001 (-4.1A)
 1.46A 2v3dB-1f4hA:
4.1		 2v3dB-1f4hA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnx BETA-GLUCOSIDASE

(Streptomyces
sp.) 		PF00232
(Glyco_hydro_1) 		5 ASN A 177
GLU A 178
TYR A 309
GLU A 383
TRP A 430
 None
 0.86A 2v3dB-1gnxA:
16.0		 2v3dB-1gnxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzj EGI

(Thermoascus
aurantiacus) 		PF00150
(Cellulase) 		5 ASN A 132
GLU A 133
TYR A 200
GLU A 240
TRP A 273
 None
 0.89A 2v3dB-1gzjA:
6.3		 2v3dB-1gzjA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II

(Saccharomyces
cerevisiae) 		PF00150
(Cellulase) 		5 ASN A 231
GLU A 232
TYR A 297
GLU A 334
TRP A 409
 None
GOL  A1450 ( 4.7A)
GOL  A1450 ( 4.8A)
GOL  A1450 ( 4.1A)
GOL  A1450 (-3.5A)
 0.82A 2v3dB-1h4pA:
12.7		 2v3dB-1h4pA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		5 ASN A 185
GLU A 186
TYR A 328
GLU A 401
TRP A 452
 None
 0.84A 2v3dB-1hxjA:
2.6		 2v3dB-1hxjA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		5 ASN A 159
GLU A 160
PHE A 115
GLU A 277
TRP A 315
 XYP  A 601 (-3.1A)
XYP  A 601 (-2.2A)
XYP  A 601 (-4.5A)
XYP  A 601 (-2.7A)
XYP  A 601 (-4.1A)
 0.68A 2v3dB-1px8A:
18.1		 2v3dB-1px8A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		5 ASN A 159
GLU A 160
TYR A 230
GLU A 277
TRP A 315
 XYP  A 601 (-3.1A)
XYP  A 601 (-2.2A)
None
XYP  A 601 (-2.7A)
XYP  A 601 (-4.1A)
 0.74A 2v3dB-1px8A:
18.1		 2v3dB-1px8A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvb BETA-GLYCOSIDASE

(Thermosphaera
aggregans) 		PF00232
(Glyco_hydro_1) 		5 ASN A 207
GLU A 208
TYR A 321
GLU A 386
TRP A 424
 None
 0.81A 2v3dB-1qvbA:
15.2		 2v3dB-1qvbA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh9 ENDO-BETA-MANNANASE

(Solanum
lycopersicum) 		PF00150
(Cellulase) 		5 ASN A 203
GLU A 204
TYR A 279
GLU A 318
TRP A 360
 None
 0.89A 2v3dB-1rh9A:
16.3		 2v3dB-1rh9A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr1 BETA-GLUCOSIDASE A

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		5 ASN A 165
GLU A 166
TYR A 296
GLU A 352
TRP A 398
 None
GOL  A2000 ( 4.4A)
GOL  A2000 (-4.0A)
GOL  A2000 (-3.8A)
GOL  A2000 (-3.2A)
 0.88A 2v3dB-1tr1A:
16.8		 2v3dB-1tr1A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus) 		PF00232
(Glyco_hydro_1) 		5 ASN A 205
GLU A 206
TYR A 322
GLU A 387
TRP A 425
 None
 0.84A 2v3dB-1uwiA:
15.1		 2v3dB-1uwiA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor) 		PF00232
(Glyco_hydro_1) 		5 ASN A 188
GLU A 189
TYR A 331
GLU A 404
TRP A 453
 None
 0.79A 2v3dB-1v02A:
2.7		 2v3dB-1v02A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vff BETA-GLUCOSIDASE

(Pyrococcus
horikoshii) 		PF00232
(Glyco_hydro_1) 		5 ASN A 154
GLU A 155
TYR A 267
GLU A 324
TRP A 362
 None
 0.85A 2v3dB-1vffA:
16.0		 2v3dB-1vffA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjz ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		5 ASN A 138
GLU A 139
TYR A 200
GLU A 259
TRP A 292
 None
 0.89A 2v3dB-1vjzA:
16.5		 2v3dB-1vjzA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcg THIOGLUCOSIDASE

(Brevicoryne
brassicae) 		PF00232
(Glyco_hydro_1) 		5 ASN A 166
GLU A 167
TYR A 309
GLU A 374
TRP A 416
 GOL  A1465 (-2.9A)
GOL  A1466 ( 3.1A)
GOL  A1466 ( 3.7A)
GOL  A1465 (-2.6A)
GOL  A1465 (-3.5A)
 0.77A 2v3dB-1wcgA:
15.5		 2v3dB-1wcgA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		5 ASN A 157
GLU A 158
TYR A 225
GLU A 253
TRP A 282
 NA  A 505 ( 4.7A)
NA  A 505 (-2.9A)
None
NA  A 505 (-2.8A)
None
 0.77A 2v3dB-1wkyA:
10.7		 2v3dB-1wkyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		6 ASP A 201
ASN A 441
TYR A 483
GLU A 521
TRP A 552
ASN A 100
 NA  A7501 (-2.7A)
None
None
None
NA  A7501 (-4.7A)
NA  A7501 (-4.9A)
 1.33A 2v3dB-1yq2A:
4.3		 2v3dB-1yq2A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		5 ASN A 159
GLU A 160
PHE A 115
GLU A 278
TRP A 316
 None
 0.80A 2v3dB-2bs9A:
19.6		 2v3dB-2bs9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		5 ASN A 159
GLU A 160
TYR A 230
GLU A 278
TRP A 316
 None
 0.72A 2v3dB-2bs9A:
19.6		 2v3dB-2bs9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF12891
(Glyco_hydro_44) 		5 ASN A 185
GLU A 186
TYR A 285
GLU A 359
TRP A 392
 CTT  A 800 (-3.2A)
CTT  A 800 ( 2.9A)
CTT  A 800 (-4.0A)
CTT  A 800 (-2.6A)
CTT  A 800 ( 3.9A)
 0.86A 2v3dB-2e0pA:
13.0		 2v3dB-2e0pA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		5 ASN A 165
GLU A 166
TYR A 295
GLU A 351
TRP A 398
 IDE  A1446 (-3.1A)
IDE  A1446 (-2.5A)
IDE  A1446 (-3.5A)
IDE  A1446 (-2.5A)
IDE  A1446 (-3.6A)
 0.84A 2v3dB-2j7cA:
16.6		 2v3dB-2j7cA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		5 ASN A 206
GLU A 207
TYR A 345
GLU A 416
TRP A 465
 None
 0.68A 2v3dB-2jf7A:
2.6		 2v3dB-2jf7A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		5 ASN A 159
GLU A 160
TYR A 299
GLU A 375
TRP A 421
 None
 0.90A 2v3dB-2pbgA:
17.1		 2v3dB-2pbgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whl BETA-MANNANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		5 ASN A 126
GLU A 127
TYR A 194
GLU A 222
TRP A 251
 None
None
None
None
MAN  A1301 (-4.5A)
 0.82A 2v3dB-2whlA:
5.7		 2v3dB-2whlA:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB

(Salmonella
enterica) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		8 ASP A  94
TRP A 144
ASN A 195
GLU A 196
TYR A 270
GLU A 294
TRP A 331
ASN A 346
 GOL  A1449 (-2.7A)
GOL  A1449 (-4.2A)
GOL  A1449 (-3.5A)
GOL  A1449 (-3.7A)
None
GOL  A1449 (-2.3A)
GOL  A1449 (-4.1A)
GOL  A1449 (-4.4A)
 0.36A 2v3dB-2wnwA:
49.2		 2v3dB-2wnwA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB

(Salmonella
enterica) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		6 ASP A  94
TRP A 144
ASN A 195
GLU A 294
TRP A 331
ASN A 342
 GOL  A1449 (-2.7A)
GOL  A1449 (-4.2A)
GOL  A1449 (-3.5A)
GOL  A1449 (-2.3A)
GOL  A1449 (-4.1A)
None
 1.21A 2v3dB-2wnwA:
49.2		 2v3dB-2wnwA:
32.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		6 TRP A 113
ASN A 164
GLU A 165
TYR A 232
GLU A 253
TRP A 289
 XYP  A1001 (-3.9A)
XYP  A1001 (-3.1A)
XYP  A1001 ( 2.4A)
IMD  A1417 (-3.8A)
XYP  A1001 (-2.8A)
XYP  A1001 (-4.2A)
 0.66A 2v3dB-2y24A:
35.0		 2v3dB-2y24A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahx BETA-GLUCOSIDASE A

(Clostridium
cellulovorans) 		PF00232
(Glyco_hydro_1) 		5 ASN A 165
GLU A 166
TYR A 296
GLU A 352
TRP A 399
 None
 0.81A 2v3dB-3ahxA:
2.8		 2v3dB-3ahxA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahy BETA-GLUCOSIDASE

(Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		5 ASN A 164
GLU A 165
TYR A 298
GLU A 367
TRP A 417
 TRS  A 500 ( 4.8A)
TRS  A 500 (-2.9A)
TRS  A 500 (-4.1A)
TRS  A 500 (-3.2A)
TRS  A 500 ( 4.1A)
 0.84A 2v3dB-3ahyA:
15.4		 2v3dB-3ahyA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		5 ASN A 190
GLU A 191
TYR A 334
GLU A 407
TRP A 455
 None
HBO  A 900 (-2.5A)
HBO  A 900 ( 4.9A)
HBO  A 900 (-3.9A)
None
 0.82A 2v3dB-3aivA:
2.7		 2v3dB-3aivA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		5 ASN A 200
GLU A 201
TYR A 299
GLU A 342
TRP A 377
 None
CBI  A 459 ( 4.0A)
None
None
None
 0.85A 2v3dB-3axxA:
14.8		 2v3dB-3axxA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		6 ASP A 227
ASN A 483
TYR A 525
GLU A 548
TRP A 579
ASN A 121
 NA  A   4 (-2.8A)
None
None
None
None
MG  A   1 ( 4.8A)
 1.44A 2v3dB-3bgaA:
8.0		 2v3dB-3bgaA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF14587
(Glyco_hydr_30_2) 		5 ASN A 208
GLU A 209
TYR A 302
GLU A 335
TRP A 380
 None
 0.40A 2v3dB-3clwA:
31.4		 2v3dB-3clwA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		5 ASN A 179
GLU A 180
TYR A 279
GLU A 352
TRP A 385
 None
 0.83A 2v3dB-3ik2A:
15.2		 2v3dB-3ik2A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jug BETA-MANNANASE

(Bacillus sp.
N16-5) 		PF00150
(Cellulase) 		5 ASN A 157
GLU A 158
TYR A 225
GLU A 253
TRP A 282
 None
 0.81A 2v3dB-3jugA:
2.2		 2v3dB-3jugA:
20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		7 ASP A 127
TRP A 179
ASN A 234
GLU A 235
TYR A 313
GLU A 340
TRP A 381
 None
 0.77A 2v3dB-3kehA:
62.6		 2v3dB-3kehA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		6 ASP A 127
TRP A 179
ASN A 234
GLU A 340
TRP A 381
ASN A 392
 None
 1.28A 2v3dB-3kehA:
62.6		 2v3dB-3kehA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl0 GLUCURONOXYLANASE
XYNC

(Bacillus
subtilis) 		PF17189
(Glyco_hydro_30C) 		6 TRP A  85
ASN A 139
GLU A 140
TYR A 204
GLU A 229
TRP A 268
 None
None
HIS  A 405 (-2.7A)
HIS  A 405 ( 3.5A)
HIS  A 406 (-3.2A)
HIS  A 406 ( 3.2A)
 0.53A 2v3dB-3kl0A:
32.7		 2v3dB-3kl0A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmw ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		5 ASN A 135
GLU A 136
TYR A 198
GLU A 253
TRP A 286
 CD  A 320 ( 4.9A)
CD  A 320 (-2.5A)
None
CD  A 320 (-2.9A)
None
 0.88A 2v3dB-3mmwA:
15.9		 2v3dB-3mmwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		5 ASN A 178
GLU A 179
TYR A 322
GLU A 393
TRP A 442
 TRS  A1164 ( 4.6A)
TRS  A1164 (-2.9A)
TRS  A1164 (-4.6A)
TRS  A1164 (-3.2A)
TRS  A1164 (-3.6A)
 0.76A 2v3dB-3ptkA:
2.7		 2v3dB-3ptkA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qom 6-PHOSPHO-BETA-GLUCO
SIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		5 ASN A 179
GLU A 180
TYR A 317
GLU A 375
TRP A 423
 None
BGC  A 479 (-2.9A)
BGC  A 479 ( 4.8A)
None
None
 0.87A 2v3dB-3qomA:
15.3		 2v3dB-3qomA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr3 ENDOGLUCANASE EG-II

(Trichoderma
reesei) 		PF00150
(Cellulase) 		5 ASN A 147
GLU A 148
TYR A 220
GLU A 259
TRP A 292
 None
SO4  A 346 ( 4.1A)
SO4  A 346 (-4.6A)
SO4  A 346 (-3.6A)
SO4  A 346 (-3.3A)
 0.82A 2v3dB-3qr3A:
18.5		 2v3dB-3qr3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		5 ASN A 166
GLU A 167
TYR A 228
GLU A 283
TRP A 316
 None
GLC  A 402 (-2.9A)
GLC  A 402 ( 3.4A)
GLC  A 403 (-2.5A)
GLC  A 403 (-3.4A)
 0.85A 2v3dB-3rjyA:
12.7		 2v3dB-3rjyA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vup BETA-1,4-MANNANASE

(Aplysia kurodai) 		PF00150
(Cellulase) 		5 ASN A 161
GLU A 162
TYR A 264
GLU A 293
TRP A 322
 TRS  A 401 (-2.7A)
TRS  A 401 (-3.0A)
TRS  A 401 ( 4.8A)
TRS  A 401 (-2.7A)
TRS  A 401 (-3.8A)
 0.85A 2v3dB-3vupA:
13.9		 2v3dB-3vupA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE

(Caldanaerobius
polysaccharolyticus) 		PF00150
(Cellulase) 		5 ASN A 136
GLU A 137
TYR A 198
GLU A 258
TRP A 291
 TRS  A 401 (-3.0A)
TRS  A 401 (-2.7A)
TRS  A 401 ( 4.9A)
TRS  A 401 (-2.8A)
TRS  A 401 (-3.6A)
 0.79A 2v3dB-3w0kA:
16.1		 2v3dB-3w0kA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w53 BETA-GLUCOSIDASE

(Micrococcus
antarcticus) 		PF00232
(Glyco_hydro_1) 		5 ASN A 169
GLU A 170
TYR A 300
GLU A 377
TRP A 424
 None
TRS  A 501 (-2.7A)
TRS  A 501 (-3.8A)
TRS  A 501 (-3.0A)
TRS  A 501 ( 4.1A)
 0.89A 2v3dB-3w53A:
15.1		 2v3dB-3w53A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6m 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		5 ASN A 200
GLU A 201
TYR A 299
GLU A 342
TRP A 377
 None
 0.87A 2v3dB-3w6mA:
6.1		 2v3dB-3w6mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh7 BETA-GLUCOSIDASE

(metagenomes) 		PF00232
(Glyco_hydro_1) 		5 ASN A 165
GLU A 166
TYR A 295
GLU A 352
TRP A 399
 FCB  A 501 (-2.9A)
FCB  A 501 (-2.5A)
FCB  A 501 (-4.6A)
FCB  A 501 (-2.7A)
FCB  A 501 (-3.6A)
 0.82A 2v3dB-3wh7A:
15.4		 2v3dB-3wh7A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh9 ENDO-BETA-1,4-MANNAN
ASE

(Aspergillus
niger) 		PF00150
(Cellulase) 		5 ASN A 167
GLU A 168
TYR A 243
GLU A 276
TRP A 306
 TRS  A 404 (-2.7A)
TRS  A 404 (-2.9A)
TRS  A 404 ( 4.5A)
TRS  A 404 (-2.8A)
TRS  A 404 (-3.7A)
 0.86A 2v3dB-3wh9A:
2.1		 2v3dB-3wh9A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq4 BETA-PRIMEVEROSIDASE

(Camellia
sinensis) 		PF00232
(Glyco_hydro_1) 		5 ASN A 202
GLU A 203
TYR A 345
GLU A 416
TRP A 463
 None
 0.85A 2v3dB-3wq4A:
6.9		 2v3dB-3wq4A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq8 BETA-GLUCOSIDASE

(Pyrococcus
furiosus) 		PF00232
(Glyco_hydro_1) 		5 ASN A 206
GLU A 207
TYR A 307
GLU A 372
TRP A 410
 None
 0.71A 2v3dB-3wq8A:
14.8		 2v3dB-3wq8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsu BETA-MANNANASE

(Streptomyces
thermolilacinus) 		PF00150
(Cellulase) 		5 ASN A 177
GLU A 178
TYR A 246
GLU A 273
TRP A 303
 NA  A 402 ( 4.8A)
NA  A 402 (-2.8A)
GOL  A 403 (-4.6A)
NA  A 402 (-2.8A)
None
 0.74A 2v3dB-3wsuA:
15.5		 2v3dB-3wsuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF00150
(Cellulase) 		5 ASN A 168
GLU A 169
TYR A 243
GLU A 276
TRP A 308
 TRS  A1352 (-2.7A)
TRS  A1352 (-2.8A)
TRS  A1352 ( 4.5A)
TRS  A1352 (-2.8A)
TRS  A1352 (-3.7A)
 0.84A 2v3dB-3zizA:
3.0		 2v3dB-3zizA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		5 ASN A 163
GLU A 164
TYR A 284
GLU A 338
TRP A 385
 GOL  A 902 (-2.9A)
GOL  A 902 ( 3.4A)
None
GOL  A 902 (-2.5A)
GOL  A 902 (-3.8A)
 0.86A 2v3dB-3zjkA:
16.4		 2v3dB-3zjkA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awe ENDO-BETA-D-1,4-MANN
ANASE

(Neurospora
sitophila) 		PF00150
(Cellulase) 		5 ASN A 180
GLU A 181
TYR A 268
GLU A 301
TRP A 344
 TRS  A1391 (-2.7A)
TRS  A1391 ( 2.7A)
TRS  A1391 (-4.4A)
TRS  A1391 (-2.8A)
TRS  A1391 (-3.8A)
 0.89A 2v3dB-4aweA:
6.3		 2v3dB-4aweA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		5 TRP A 135
ASN A 181
GLU A 182
TYR A 238
GLU A 258
 2DG  A1001 (-4.1A)
2DG  A1001 ( 4.2A)
2DG  A1001 (-3.5A)
2DG  A1001 (-4.8A)
2DG  A1001 (-1.6A)
 0.68A 2v3dB-4ccdA:
28.5		 2v3dB-4ccdA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2

(Streptococcus
pneumoniae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ASN A 563
GLU A 564
TYR A 624
GLU A 645
TRP A 708
 DGJ  A1985 (-2.8A)
EDO  A2021 ( 3.0A)
EDO  A2021 ( 4.4A)
DGJ  A1985 (-2.9A)
DGJ  A1985 (-3.7A)
 0.65A 2v3dB-4cu8A:
13.4		 2v3dB-4cu8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk9 CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF00150
(Cellulase) 		5 ASN A 177
GLU A 178
TYR A 246
GLU A 273
TRP A 303
 None
 0.72A 2v3dB-4fk9A:
2.7		 2v3dB-4fk9A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmv GLUCURONOARABINOXYLA
N
ENDO-1,4-BETA-XYLANA
SE

([Clostridium]
papyrosolvens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		6 TRP A  88
ASN A 142
GLU A 143
TYR A 207
GLU A 232
TRP A 265
 None
 0.30A 2v3dB-4fmvA:
33.6		 2v3dB-4fmvA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN

(Thermotoga
maritima;
Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		5 ASN A 172
GLU A 173
TYR A 302
GLU A 371
TRP A 419
 None
 0.78A 2v3dB-4gxpA:
2.9		 2v3dB-4gxpA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		5 ASN A 207
GLU A 208
TYR A 320
GLU A 385
TRP A 423
 GOL  A 505 (-2.9A)
GOL  A 505 (-3.3A)
None
GOL  A 505 (-2.7A)
GOL  A 505 (-3.6A)
 0.79A 2v3dB-4ha4A:
15.5		 2v3dB-4ha4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu0 CELLULASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		5 ASN A 192
GLU A 193
TYR A 260
GLU A 289
TRP A 328
 CTT  A 401 (-2.8A)
CTT  A 401 (-2.8A)
CTT  A 401 (-4.3A)
CTT  A 401 (-2.9A)
CTT  A 401 (-3.8A)
 0.72A 2v3dB-4hu0A:
3.2		 2v3dB-4hu0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium) 		PF00232
(Glyco_hydro_1) 		5 ASN A 202
GLU A 203
TYR A 332
GLU A 387
TRP A 434
 BGC  A 501 (-3.1A)
BGC  A 501 (-2.3A)
BGC  A 501 (-4.3A)
BGC  A 501 (-2.6A)
BGC  A 501 (-3.6A)
 0.85A 2v3dB-4hz8A:
16.8		 2v3dB-4hz8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 ASN A 412
GLU A 413
TYR A 468
GLU A 504
TRP A 549
 None
1KV  A 701 (-3.4A)
1KV  A 701 ( 4.5A)
None
None
 0.76A 2v3dB-4jhzA:
18.2		 2v3dB-4jhzA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 ASN A 407
GLU A 408
TYR A 464
GLU A 501
TRP A 546
 None
 0.80A 2v3dB-4jklA:
17.6		 2v3dB-4jklA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx4 ENDOGLUCANASE(ENDO-1
,4-BETA-GLUCANASE)PR
OTEIN

(Pseudomonas
stutzeri) 		PF00150
(Cellulase) 		5 ASN A 143
GLU A 144
TYR A 208
GLU A 252
TRP A 283
 TRS  A 401 (-2.5A)
TRS  A 401 (-1.8A)
TRS  A 401 ( 4.9A)
TRS  A 401 (-2.6A)
TRS  A 401 ( 3.4A)
 0.89A 2v3dB-4lx4A:
2.2		 2v3dB-4lx4A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m29 BETA-XYLOSIDASE

(Caulobacter
vibrioides) 		PF01229
(Glyco_hydro_39) 		5 ASN A 162
GLU A 163
PHE A 119
GLU A 280
TRP A 318
 None
 0.77A 2v3dB-4m29A:
19.9		 2v3dB-4m29A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m29 BETA-XYLOSIDASE

(Caulobacter
vibrioides) 		PF01229
(Glyco_hydro_39) 		5 ASN A 162
GLU A 163
TYR A 231
GLU A 280
TRP A 318
 None
 0.78A 2v3dB-4m29A:
19.9		 2v3dB-4m29A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		5 ASN A 165
GLU A 166
TYR A 308
GLU A 377
TRP A 427
 None
GOL  A 507 (-3.2A)
GOL  A 507 (-4.1A)
GOL  A 507 (-3.8A)
GOL  A 507 (-3.5A)
 0.80A 2v3dB-4mdpA:
15.3		 2v3dB-4mdpA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oou BETA-1,4-MANNANASE

(Cryptopygus
antarcticus) 		no annotation 5 ASN B 180
GLU B 181
TYR B 282
GLU B 312
TRP B 341
 TRS  B 401 (-2.8A)
TRS  B 401 (-3.0A)
None
TRS  B 401 (-2.9A)
TRS  B 401 (-4.1A)
 0.89A 2v3dB-4oouB:
5.2		 2v3dB-4oouB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptx GLYCOSIDE HYDROLASE
FAMILY 1

(Halothermothrix
orenii) 		PF00232
(Glyco_hydro_1) 		5 ASN A 165
GLU A 166
TYR A 296
GLU A 354
TRP A 401
 BGC  A 501 (-3.3A)
BGC  A 501 (-2.4A)
BGC  A 501 (-4.1A)
BGC  A 501 (-2.7A)
BGC  A 501 (-3.6A)
 0.85A 2v3dB-4ptxA:
16.1		 2v3dB-4ptxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaw XYN30D

(Paenibacillus
barcinonensis) 		PF03422
(CBM_6)
PF17189
(Glyco_hydro_30C) 		6 TRP A  84
ASN A 137
GLU A 138
TYR A 203
GLU A 228
TRP A 267
 None
 0.57A 2v3dB-4qawA:
33.1		 2v3dB-4qawA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		5 ASN A 178
GLU A 179
TYR A 318
GLU A 389
TRP A 436
 MVL  A 501 (-2.9A)
MVL  A 501 (-2.6A)
MVL  A 501 (-3.8A)
MVL  A 501 (-2.8A)
MVL  A 501 (-3.7A)
 0.82A 2v3dB-4re2A:
3.8		 2v3dB-4re2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uq9 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF17189
(Glyco_hydro_30C) 		6 TRP A  81
ASN A 135
GLU A 136
TYR A 200
GLU A 225
TRP A 264
 None
 0.49A 2v3dB-4uq9A:
33.1		 2v3dB-4uq9A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7v CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		5 ASN A 133
GLU A 134
TYR A 206
GLU A 246
TRP A 279
 None
CBI  A 401 (-2.8A)
CBI  A 401 (-4.5A)
None
CBI  A 402 (-4.2A)
 0.78A 2v3dB-4w7vA:
2.7		 2v3dB-4w7vA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8b EXO-XYLOGLUCANASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		5 ASN A 292
GLU A 293
TYR A 370
GLU A 431
TRP A 471
 GLC  A 601 (-3.1A)
GLC  A 601 (-3.0A)
GLC  A 601 (-4.5A)
GLC  A 601 (-2.8A)
GLC  A 601 ( 4.0A)
 0.80A 2v3dB-4w8bA:
15.1		 2v3dB-4w8bA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ASN A 446
GLU A 447
TYR A 511
GLU A 532
TRP A 593
 None
 0.74A 2v3dB-4ypjA:
14.1		 2v3dB-4ypjA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzt CELLULOSE HYDROLASE

(Bacillus
licheniformis) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		5 ASN A 158
GLU A 159
TYR A 222
GLU A 268
TRP A 301
 BGC  A 803 (-2.9A)
BGC  A 803 (-2.4A)
BGC  A 803 ( 4.9A)
BGC  A 803 (-2.8A)
BGC  A 803 (-3.6A)
 0.86A 2v3dB-4yztA:
17.4		 2v3dB-4yztA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c70 GLUCURONIDASE

(Aspergillus
oryzae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		6 ASP A 162
ASN A 413
GLU A 414
TYR A 469
GLU A 505
TRP A 550
 None
 0.92A 2v3dB-5c70A:
17.3		 2v3dB-5c70A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg0 BETA-GLUCOSIDASE

(Spodoptera
frugiperda) 		PF00232
(Glyco_hydro_1) 		5 ASN A 186
GLU A 187
TYR A 331
GLU A 399
TRP A 444
 None
TRS  A 603 (-2.7A)
TRS  A 603 (-4.7A)
TRS  A 603 (-2.8A)
TRS  A 603 ( 4.2A)
 0.86A 2v3dB-5cg0A:
2.5		 2v3dB-5cg0A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum) 		PF02055
(Glyco_hydro_30) 		6 TRP A  87
ASN A 140
GLU A 141
TYR A 209
GLU A 230
TRP A 263
 P6G  A 622 (-4.0A)
P6G  A 622 (-3.3A)
NA  A 607 ( 2.1A)
P6G  A 622 ( 3.4A)
P6G  A 622 ( 2.7A)
P6G  A 622 (-3.5A)
 0.59A 2v3dB-5cxpA:
34.6		 2v3dB-5cxpA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8w ENDOGLUCANASE

(Ganoderma
lucidum) 		PF00150
(Cellulase) 		5 ASN A 163
GLU A 164
TYR A 237
GLU A 276
TRP A 309
 None
 0.89A 2v3dB-5d8wA:
6.4		 2v3dB-5d8wA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ASN A 446
GLU A 447
TYR A 511
GLU A 533
TRP A 591
 None
 0.76A 2v3dB-5dmyA:
14.3		 2v3dB-5dmyA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt5 BETA-GLUCOSIDASE

(Exiguobacterium
antarcticum) 		PF00232
(Glyco_hydro_1) 		5 ASN A 161
GLU A 162
TYR A 294
GLU A 350
TRP A 396
 None
 0.77A 2v3dB-5dt5A:
15.9		 2v3dB-5dt5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbk BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		5 ASN A 165
GLU A 166
TYR A 298
GLU A 367
TRP A 417
 None
GOL  A 501 (-2.9A)
GOL  A 501 (-4.1A)
GOL  A 501 (-3.8A)
GOL  A 501 (-3.9A)
 0.82A 2v3dB-5jbkA:
2.6		 2v3dB-5jbkA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		5 ASN A 171
GLU A 172
TYR A 316
GLU A 384
TRP A 434
 None
 0.82A 2v3dB-5jboA:
14.6		 2v3dB-5jboA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		7 ASP A 131
TRP A 179
ASN A 237
GLU A 238
TYR A 316
GLU A 339
TRP A 377
 None
 0.38A 2v3dB-5ngkA:
46.1		 2v3dB-5ngkA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 5 ASN A 163
GLU A 164
TYR A 291
GLU A 349
TRP A 395
 NOJ  A 506 (-3.1A)
NOJ  A 506 (-2.5A)
NOJ  A 506 (-3.8A)
NOJ  A 506 (-2.6A)
NOJ  A 506 (-3.2A)
 0.82A 2v3dB-5ns8A:
18.1		 2v3dB-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogz -

(-) 		no annotation 5 ASN A 165
GLU A 166
TYR A 296
GLU A 355
TRP A 402
 None
 0.87A 2v3dB-5ogzA:
16.1		 2v3dB-5ogzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ASN A 441
GLU A 442
TYR A 498
GLU A 519
TRP A 578
 TRS  A 909 (-3.9A)
EDO  A 908 ( 2.7A)
None
TRS  A 909 (-2.6A)
TRS  A 909 (-3.5A)
 0.75A 2v3dB-5t98A:
15.2		 2v3dB-5t98A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ASN A 435
GLU A 436
TYR A 531
GLU A 552
TRP A 575
 GIF  A 901 ( 4.0A)
GIF  A 901 (-2.9A)
None
GIF  A 901 (-2.8A)
GIF  A 901 (-4.0A)
 0.69A 2v3dB-5t9gA:
14.4		 2v3dB-5t9gA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		5 ASN A 425
GLU A 426
TYR A 495
GLU A 526
TRP A 573
 GOL  A 901 (-3.2A)
GOL  A 901 (-2.5A)
None
GOL  A 901 (-2.2A)
GOL  A 901 (-3.3A)
 0.75A 2v3dB-5uj6A:
5.3		 2v3dB-5uj6A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgz BETA-GLYCOSIDASE

(uncultured
microorganism) 		no annotation 5 ASN A 169
GLU A 170
TYR A 299
GLU A 356
TRP A 403
 None
GOL  A 502 ( 2.8A)
GOL  A 501 (-4.3A)
GOL  A 501 (-3.9A)
GOL  A 501 (-3.5A)
 0.86A 2v3dB-5xgzA:
2.8		 2v3dB-5xgzA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 5 ASN A 425
GLU A 426
TYR A 480
GLU A 501
TRP A 526
 None
 0.83A 2v3dB-6b6lA:
14.1		 2v3dB-6b6lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 5 ASN A 424
GLU A 425
TYR A 481
GLU A 516
TRP A 561
 E0V  A 701 (-3.3A)
E0V  A 701 (-2.6A)
E0V  A 701 (-4.4A)
E0V  A 701 (-2.6A)
E0V  A 701 (-3.9A)
 0.72A 2v3dB-6bo6A:
15.1		 2v3dB-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 6 ASP A 207
ASN A 440
TYR A 482
GLU A 517
TRP A 548
ASN A 110
 NA  A1105 (-2.6A)
None
None
None
None
None
 1.29A 2v3dB-6etzA:
11.1		 2v3dB-6etzA:
12.81