SIMILAR PATTERNS OF AMINO ACIDS FOR 2V0Z_O_C41O1327_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus)
PF00026
(Asp)
4 TYR A  14
SER A  35
TYR A  75
THR A  77
None
0.72A 2v0zO-1b5fA:
28.5
2v0zO-1b5fA:
34.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)


(Escherichia
coli)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
4 TYR A 312
THR A 293
LEU A 300
THR A 390
None
0.97A 2v0zO-1bbuA:
undetectable
2v0zO-1bbuA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE


(Desulfovibrio
desulfuricans)
PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
4 SER A 577
THR A 576
PRO A 582
THR A 484
None
0.97A 2v0zO-1dgjA:
undetectable
2v0zO-1dgjA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN


(Escherichia
coli)
PF00899
(ThiF)
4 TYR B 215
THR B 165
PRO B 148
LEU B 124
None
1.16A 2v0zO-1jwaB:
undetectable
2v0zO-1jwaB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum)
PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ)
4 TYR A 273
TYR A 729
THR A 727
THR A1004
None
1.19A 2v0zO-1k32A:
undetectable
2v0zO-1k32A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae)
PF00291
(PALP)
PF14821
(Thr_synth_N)
4 TYR A  88
SER A  89
THR A  90
PRO A 119
None
0.76A 2v0zO-1kl7A:
undetectable
2v0zO-1kl7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2)
PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb)
4 THR B 128
PRO B 150
LEU B 149
THR A  88
None
1.11A 2v0zO-1mu2B:
undetectable
2v0zO-1mu2B:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvl LEUCOCIDIN

(Staphylococcus
aureus)
PF07968
(Leukocidin)
4 SER A  45
TYR A 118
SER A 117
THR A  50
None
1.20A 2v0zO-1pvlA:
undetectable
2v0zO-1pvlA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmn ALPHA-1-ANTICHYMOTRY
PSIN


(Homo sapiens)
PF00079
(Serpin)
4 SER A 178
SER A 314
THR A 313
LEU A 304
None
1.14A 2v0zO-1qmnA:
undetectable
2v0zO-1qmnA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1smr RENIN

(Mus musculus)
PF00026
(Asp)
4 SER A  35
TYR A  75
PRO A 111
THR A 295
None
0.60A 2v0zO-1smrA:
50.8
2v0zO-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1smr RENIN

(Mus musculus)
PF00026
(Asp)
4 TYR A  14
SER A  35
TYR A  75
PRO A 111
None
0.46A 2v0zO-1smrA:
50.8
2v0zO-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1smr RENIN

(Mus musculus)
PF00026
(Asp)
4 TYR A  14
TYR A  75
PRO A 111
LEU A 114
None
0.60A 2v0zO-1smrA:
50.8
2v0zO-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g1s RENIN

(Homo sapiens)
PF00026
(Asp)
7 TYR A  15
SER A  36
TYR A  78
SER A  79
THR A  80
PRO A 113
LEU A 116
None
4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
4IG  A 885 (-3.0A)
4IG  A 885 (-3.5A)
4IG  A 885 (-4.7A)
4IG  A 885 (-3.5A)
0.64A 2v0zO-2g1sA:
53.2
2v0zO-2g1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g1s RENIN

(Homo sapiens)
PF00026
(Asp)
5 TYR A  15
SER A  36
TYR A  78
SER A  79
THR A 304
None
4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
4IG  A 885 (-3.0A)
None
0.65A 2v0zO-2g1sA:
53.2
2v0zO-2g1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g1s RENIN

(Homo sapiens)
PF00026
(Asp)
4 TYR A  16
SER A  36
SER A  79
THR A  80
None
4IG  A 885 ( 4.8A)
4IG  A 885 (-3.0A)
4IG  A 885 (-3.5A)
0.90A 2v0zO-2g1sA:
53.2
2v0zO-2g1sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT


(Escherichia
coli)
PF00456
(Transketolase_N)
4 TYR A 596
SER A 493
THR A 494
PRO A 660
None
1.10A 2v0zO-2g28A:
undetectable
2v0zO-2g28A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE


(Helicobacter
pylori)
PF00698
(Acyl_transf_1)
4 TYR A  59
SER A  12
SER A  92
LEU A 113
None
1.14A 2v0zO-2h1yA:
undetectable
2v0zO-2h1yA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hig 6-PHOSPHO-1-FRUCTOKI
NASE


(Trypanosoma
brucei)
PF00365
(PFK)
4 SER A 172
THR A 195
LEU A 206
THR A 167
None
1.12A 2v0zO-2higA:
undetectable
2v0zO-2higA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuc ALKALINE PHOSPHATASE

(Antarctic
bacterium TAB5)
PF00245
(Alk_phosphatase)
4 TYR B  55
SER B  52
THR B  53
PRO B  61
None
1.14A 2v0zO-2iucB:
undetectable
2v0zO-2iucB:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nul PEPTIDYLPROLYL
ISOMERASE


(Escherichia
coli)
PF00160
(Pro_isomerase)
4 SER A  93
THR A  23
LEU A  76
THR A  64
None
1.10A 2v0zO-2nulA:
undetectable
2v0zO-2nulA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50


(Geobacillus
stearothermophilus)
PF00135
(COesterase)
4 TYR A 368
THR A 367
LEU A 225
THR A 351
TYR  A 368 ( 1.3A)
THR  A 367 ( 0.8A)
LEU  A 225 ( 0.6A)
THR  A 351 ( 0.8A)
1.09A 2v0zO-2ogsA:
undetectable
2v0zO-2ogsA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ol8 OUTER SURFACE
PROTEIN A


(Borreliella
burgdorferi)
PF00820
(Lipoprotein_1)
4 SER O  37
SER O 120
THR O 136
THR O  97
None
0.92A 2v0zO-2ol8O:
undetectable
2v0zO-2ol8O:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica)
PF00781
(DAGK_cat)
4 SER A 274
THR A 140
LEU A 231
THR A 133
None
1.20A 2v0zO-2p1rA:
undetectable
2v0zO-2p1rA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Aspergillus
oryzae)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TYR A  60
THR A  37
LEU A  16
THR A  74
None
1.20A 2v0zO-2ps2A:
undetectable
2v0zO-2ps2A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA


(Escherichia
coli)
PF01297
(ZnuA)
4 SER A  31
THR A 154
LEU A 113
THR A  49
None
0.97A 2v0zO-2ps3A:
undetectable
2v0zO-2ps3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp2 UNKNOWN PROTEIN

(Photorhabdus
laumondii)
PF01823
(MACPF)
4 TYR A  96
TYR A 158
THR A 157
LEU A 313
None
1.02A 2v0zO-2qp2A:
undetectable
2v0zO-2qp2A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA


(Thermotoga
maritima)
PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
4 SER A 363
THR A 339
PRO A 318
LEU A 264
None
1.11A 2v0zO-2r9vA:
undetectable
2v0zO-2r9vA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
4 SER A  66
TYR A  59
THR A  56
LEU A  31
None
0.97A 2v0zO-2vl8A:
undetectable
2v0zO-2vl8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wok CLAVULANIC ACID
BIOSYNTHESIS
OLIGOPEPTIDE BINDING
PROTEIN 2


(Streptomyces
clavuligerus)
PF00496
(SBP_bac_5)
4 TYR A  53
TYR A  70
LEU A  62
THR A 355
None
GOL  A1561 (-4.5A)
None
None
1.15A 2v0zO-2wokA:
undetectable
2v0zO-2wokA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1


(Plasmodium
falciparum)
PF05424
(Duffy_binding)
PF15447
(NTS)
4 SER A 191
THR A  14
PRO A  13
THR A 304
None
0.93A 2v0zO-2xu0A:
undetectable
2v0zO-2xu0A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE


(Pseudomonas sp.
P-501)
no annotation 4 TYR A 320
SER A 476
TYR A 536
SER A 535
None
FAD  A 801 ( 3.7A)
SO4  A 903 ( 4.7A)
None
0.99A 2v0zO-2yr5A:
undetectable
2v0zO-2yr5A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus)
PF01979
(Amidohydro_1)
4 SER A 395
THR A 305
PRO A 259
LEU A 336
None
1.14A 2v0zO-2z00A:
undetectable
2v0zO-2z00A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE


(Mesorhizobium
japonicum)
PF08241
(Methyltransf_11)
4 SER A 142
PRO A  39
LEU A  44
THR A 196
None
None
None
EDO  A 243 (-3.0A)
1.15A 2v0zO-3bkwA:
undetectable
2v0zO-3bkwA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwx ALPHA/BETA HYDROLASE

(Novosphingobium
aromaticivorans)
PF12697
(Abhydrolase_6)
4 SER A 134
SER A 104
PRO A 266
THR A 212
None
1.15A 2v0zO-3bwxA:
undetectable
2v0zO-3bwxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana)
PF13847
(Methyltransf_31)
4 SER A 712
SER A 715
THR A 716
LEU A 786
None
1.16A 2v0zO-3htxA:
undetectable
2v0zO-3htxA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k94 THIAMIN
PYROPHOSPHOKINASE


(Geobacillus
thermodenitrificans)
PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding)
4 SER A 182
THR A 183
PRO A 156
LEU A 204
None
1.05A 2v0zO-3k94A:
undetectable
2v0zO-3k94A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksw STEROL 14-ALPHA
DEMETHYLASE


(Trypanosoma
cruzi)
PF00067
(p450)
4 SER A 296
THR A 295
PRO A 355
THR A 178
HEM  A 488 ( 4.9A)
VNF  A 490 ( 4.0A)
None
None
1.10A 2v0zO-3kswA:
undetectable
2v0zO-3kswA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Vibrio cholerae)
PF00275
(EPSP_synthase)
4 SER A 393
TYR A 417
PRO A  19
THR A 382
None
1.10A 2v0zO-3nvsA:
undetectable
2v0zO-3nvsA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oag RENIN

(Homo sapiens)
PF00026
(Asp)
4 TYR A  20
SER A  41
PRO A 118
LEU A 121
None
LPQ  A 167 ( 3.9A)
LPQ  A 167 ( 4.4A)
None
0.61A 2v0zO-3oagA:
23.7
2v0zO-3oagA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qs1 PLASMEPSIN-1

(Plasmodium
falciparum)
PF00026
(Asp)
4 TYR A  15
SER A  35
TYR A  75
SER A  77
None
006  A 330 (-4.5A)
006  A 330 (-4.3A)
006  A 330 (-2.1A)
0.93A 2v0zO-3qs1A:
41.0
2v0zO-3qs1A:
35.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6m PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Burkholderia
pseudomallei)
PF00160
(Pro_isomerase)
4 SER A  93
THR A  23
LEU A  76
THR A  64
None
None
PEG  A 165 ( 4.0A)
None
1.13A 2v0zO-3s6mA:
undetectable
2v0zO-3s6mA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL


(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
4 TYR A1162
TYR A1167
LEU A1450
THR A1552
None
0.99A 2v0zO-3topA:
undetectable
2v0zO-3topA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uid PUTATIVE
UNCHARACTERIZED
PROTEIN


(Mycolicibacterium
smegmatis)
PF08327
(AHSA1)
4 TYR A 113
SER A  88
THR A 114
THR A  81
None
1.14A 2v0zO-3uidA:
undetectable
2v0zO-3uidA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux4 ACID-ACTIVATED UREA
CHANNEL


(Helicobacter
pylori)
PF02293
(AmiS_UreI)
4 SER A 108
PRO A 165
LEU A 166
THR A 115
None
1.20A 2v0zO-3ux4A:
undetectable
2v0zO-3ux4A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE


(Arabidopsis
thaliana)
PF00202
(Aminotran_3)
PF13500
(AAA_26)
4 SER A 349
PRO A 374
LEU A 382
THR A 338
None
1.15A 2v0zO-4a0hA:
undetectable
2v0zO-4a0hA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE


(Zymomonas
mobilis)
PF00724
(Oxidored_FMN)
4 SER A 186
THR A 187
PRO A 118
LEU A 178
None
1.14A 2v0zO-4a3uA:
undetectable
2v0zO-4a3uA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ab4 XENOBIOTIC REDUCTASE
B


(Pseudomonas
putida)
PF00724
(Oxidored_FMN)
4 SER A 187
THR A 188
PRO A 119
LEU A 179
None
1.12A 2v0zO-4ab4A:
undetectable
2v0zO-4ab4A:
23.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4amt RENIN

(Homo sapiens)
PF00026
(Asp)
PF07966
(A1_Propeptide)
4 TYR A 126
SER A 127
THR A 128
PRO A 161
None
0.89A 2v0zO-4amtA:
44.0
2v0zO-4amtA:
88.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asc KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 5


(Homo sapiens)
PF01344
(Kelch_1)
4 SER A 413
TYR A 415
LEU A 429
THR A 356
None
1.19A 2v0zO-4ascA:
undetectable
2v0zO-4ascA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE


(Trypanosoma
cruzi)
PF00102
(Y_phosphatase)
4 SER A 205
TYR A 191
LEU A 122
THR A 211
None
None
FMT  A1305 (-3.7A)
None
1.10A 2v0zO-4az1A:
undetectable
2v0zO-4az1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius)
PF03512
(Glyco_hydro_52)
4 TYR A 573
SER A 648
THR A 649
THR A 633
GOL  A1753 (-3.9A)
GOL  A1751 (-2.8A)
GOL  A1751 (-3.9A)
None
1.21A 2v0zO-4c1oA:
undetectable
2v0zO-4c1oA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA


(Homo sapiens)
PF01131
(Topoisom_bac)
PF01751
(Toprim)
4 TYR A 241
SER A 240
THR A 219
LEU A 113
None
0.93A 2v0zO-4cgyA:
undetectable
2v0zO-4cgyA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT


(Vaccinia virus)
PF03341
(Pox_mRNA-cap)
4 SER B  32
TYR B 133
LEU B 128
THR B 168
None
1.11A 2v0zO-4ckeB:
undetectable
2v0zO-4ckeB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE


(Gelatoporia
subvermispora)
PF00141
(peroxidase)
PF11895
(Peroxidase_ext)
4 SER A 245
PRO A 225
LEU A 226
THR A 255
HEM  A1374 (-3.3A)
None
None
None
1.07A 2v0zO-4czpA:
undetectable
2v0zO-4czpA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN


(Methanosarcina
mazei)
PF01458
(UPF0051)
4 SER A 192
THR A 220
PRO A 247
LEU A 260
None
1.17A 2v0zO-4dn7A:
undetectable
2v0zO-4dn7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA


(Bacillus
subtilis)
PF00268
(Ribonuc_red_sm)
4 TYR A 105
SER A 106
PRO A  32
LEU A  31
None
0.99A 2v0zO-4dr0A:
undetectable
2v0zO-4dr0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcs VERSATILE PEROXIDASE
VPL2


(Pleurotus
eryngii)
PF00141
(peroxidase)
PF11895
(Peroxidase_ext)
4 SER A 230
PRO A 221
LEU A 222
THR A 240
HEM  A 401 (-3.5A)
None
None
None
1.09A 2v0zO-4fcsA:
undetectable
2v0zO-4fcsA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE


(Trypanosoma
brucei)
PF00067
(p450)
4 SER A 296
THR A 295
PRO A 355
THR A 178
HEM  A 501 (-3.2A)
VNT  A 502 ( 3.2A)
HEM  A 501 ( 4.8A)
None
1.12A 2v0zO-4g3jA:
undetectable
2v0zO-4g3jA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN


(Dyadobacter
fermentans)
PF00501
(AMP-binding)
4 SER A  43
TYR A  86
PRO A 108
THR A 179
None
0.99A 2v0zO-4gs5A:
undetectable
2v0zO-4gs5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4icq AMINOPEPTIDASE PEPS

(Streptococcus
pneumoniae)
PF02073
(Peptidase_M29)
4 TYR A 266
SER A 346
LEU A 213
THR A 335
None
0.95A 2v0zO-4icqA:
undetectable
2v0zO-4icqA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig7 UBIQUITIN C-TERMINAL
HYDROLASE 37


(Trichinella
spiralis)
PF01088
(Peptidase_C12)
4 TYR A 262
SER A 139
SER A  87
LEU A  28
None
1.08A 2v0zO-4ig7A:
undetectable
2v0zO-4ig7A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jip GTN REDUCTASE

(Agrobacterium
tumefaciens)
PF00724
(Oxidored_FMN)
4 SER A 192
THR A 193
PRO A 119
LEU A 184
None
1.19A 2v0zO-4jipA:
undetectable
2v0zO-4jipA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqb PROTEIN H03A11.1

(Caenorhabditis
elegans)
PF06702
(Fam20C)
4 TYR A 343
SER A 415
THR A 416
LEU A 406
None
1.17A 2v0zO-4kqbA:
undetectable
2v0zO-4kqbA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
4 SER A 203
TYR A 132
LEU A 177
THR A 282
None
0.93A 2v0zO-4oqjA:
undetectable
2v0zO-4oqjA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN


(Streptococcus
pyogenes)
PF16569
(GramPos_pilinBB)
4 TYR A 119
TYR A 140
THR A 132
THR A 215
None
None
None
IOD  A 601 (-3.5A)
1.03A 2v0zO-4p0dA:
undetectable
2v0zO-4p0dA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uou FUCOSE-SPECIFIC
LECTIN FLEA


(Aspergillus
fumigatus)
PF07938
(Fungal_lectin)
4 TYR A  40
SER A  66
THR A 218
LEU A 283
None
1.20A 2v0zO-4uouA:
undetectable
2v0zO-4uouA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3


(Drosophila
melanogaster)
PF07034
(ORC3_N)
4 TYR C 430
TYR C 444
SER C 440
THR C 441
None
1.11A 2v0zO-4xgcC:
undetectable
2v0zO-4xgcC:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE


(Neurospora
crassa)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch)
4 TYR A 571
SER A 568
LEU A 597
THR A 326
None
1.19A 2v0zO-4xgtA:
undetectable
2v0zO-4xgtA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk8 AUTOPHAGY PROTEIN 13

(Schizosaccharomyces
pombe)
PF10033
(ATG13)
4 SER B  58
THR B  51
LEU B 174
THR B 113
None
0.87A 2v0zO-4yk8B:
undetectable
2v0zO-4yk8B:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13


(Mus musculus)
PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8)
4 SER A 397
THR A 351
LEU A 319
THR A 423
None
1.18A 2v0zO-4z0cA:
undetectable
2v0zO-4z0cA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE


(Vibrio
vulnificus)
PF06917
(Pectate_lyase_2)
4 SER A 512
PRO A 463
LEU A 466
THR A  59
None
1.21A 2v0zO-5a29A:
undetectable
2v0zO-5a29A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN


(Candidatus
Nitrososphaera
gargensis)
PF00561
(Abhydrolase_1)
4 SER A   8
THR A  13
LEU A  88
THR A  69
None
1.12A 2v0zO-5a62A:
undetectable
2v0zO-5a62A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo7 PREDICTED PROTEIN

(Aspergillus
oryzae)
PF07938
(Fungal_lectin)
4 TYR A  40
SER A  66
THR A 218
LEU A 278
SFU  A 405 (-3.1A)
None
None
None
1.10A 2v0zO-5eo7A:
undetectable
2v0zO-5eo7A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct)
PF00291
(PALP)
4 TYR B 354
SER B 373
LEU B 313
THR B  53
None
PLP  B 501 (-2.4A)
None
None
1.16A 2v0zO-5ey5B:
undetectable
2v0zO-5ey5B:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE


(Desulfovibrio
alaskensis)
PF01228
(Gly_radical)
PF02901
(PFL-like)
4 SER A 724
THR A 730
LEU A 656
THR A 697
None
1.08A 2v0zO-5favA:
undetectable
2v0zO-5favA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE


(Desulfovibrio
alaskensis)
PF01228
(Gly_radical)
PF02901
(PFL-like)
4 TYR A 667
SER A 724
LEU A 656
THR A 697
None
0.63A 2v0zO-5favA:
undetectable
2v0zO-5favA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
ALPHA


(Yarrowia
lipolytica)
PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
4 SER A 396
THR A 372
PRO A 351
LEU A 297
None
1.10A 2v0zO-5fl7A:
undetectable
2v0zO-5fl7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjn LYSINE/ORNITHINE
DECARBOXYLASE


(Selenomonas
ruminantium)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
4 SER A  26
PRO A 223
LEU A 232
THR A  55
None
0.97A 2v0zO-5gjnA:
undetectable
2v0zO-5gjnA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7w VENOM
5'-NUCLEOTIDASE


(Naja atra)
no annotation 4 SER A 520
PRO A 187
LEU A 191
THR A 421
None
1.07A 2v0zO-5h7wA:
undetectable
2v0zO-5h7wA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA


(Caldalkalibacillus
thermarum)
PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
4 SER A 362
THR A 338
PRO A 317
LEU A 263
None
1.15A 2v0zO-5ik2A:
undetectable
2v0zO-5ik2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jju UNCHARACTERIZED
PROTEIN RV2837C


(Mycobacterium
tuberculosis)
PF01368
(DHH)
PF02272
(DHHA1)
4 SER A 189
SER A 150
THR A 152
LEU A 159
None
1.20A 2v0zO-5jjuA:
undetectable
2v0zO-5jjuA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkr KINASE SUPPRESSOR OF
RAS 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 TYR B 865
THR B 862
LEU B 829
THR B 763
None
1.13A 2v0zO-5kkrB:
undetectable
2v0zO-5kkrB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE


(Streptomyces
violaceusniger)
PF04820
(Trp_halogenase)
4 TYR A 170
SER A 460
LEU A 272
THR A 106
None
1.16A 2v0zO-5lv9A:
undetectable
2v0zO-5lv9A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m76 LIGHT CHAIN DIMER

(Homo sapiens)
no annotation 4 SER A 182
TYR A 180
SER A 179
THR A 164
None
1.08A 2v0zO-5m76A:
undetectable
2v0zO-5m76A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus)
no annotation 4 SER A 310
THR A 319
LEU A 379
THR A 254
None
1.04A 2v0zO-5mktA:
39.8
2v0zO-5mktA:
9.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5pep PEPSIN

(Sus scrofa)
PF00026
(Asp)
4 TYR A  14
SER A  35
TYR A  75
THR A  77
None
0.63A 2v0zO-5pepA:
44.9
2v0zO-5pepA:
39.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta1 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis)
no annotation 4 TYR A 404
SER A 324
THR A 347
LEU A 413
None
1.10A 2v0zO-5ta1A:
undetectable
2v0zO-5ta1A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u84 ACID CERAMIDASE

(Balaenoptera
acutorostrata)
no annotation 4 TYR A 280
TYR A 137
LEU A 276
THR A 175
None
None
I3C  A 412 (-4.7A)
None
1.11A 2v0zO-5u84A:
undetectable
2v0zO-5u84A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN


(Geobacillus sp.
Y4.1MC1)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C)
4 TYR A1272
TYR A1264
THR A1262
LEU A1434
None
1.06A 2v0zO-5u89A:
undetectable
2v0zO-5u89A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium)
PF02310
(B12-binding)
4 THR A 142
PRO A 290
LEU A 136
THR A 280
B12  A 802 ( 4.2A)
None
None
EDO  A 807 (-3.0A)
1.20A 2v0zO-5ul4A:
undetectable
2v0zO-5ul4A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1


(Schizosaccharomyces
pombe)
PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB)
4 SER A 629
SER A 110
THR A  65
LEU A 120
None
1.00A 2v0zO-5um6A:
undetectable
2v0zO-5um6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usd PEPTIDASE S66

(Bacillus
anthracis)
PF02016
(Peptidase_S66)
4 SER A 206
THR A 207
LEU A 116
THR A 237
None
0.82A 2v0zO-5usdA:
undetectable
2v0zO-5usdA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1


(Pseudomonas
aeruginosa)
PF09611
(Cas_Csy1)
4 SER A 233
TYR A 235
PRO A 266
LEU A 268
None
1.18A 2v0zO-5uz9A:
undetectable
2v0zO-5uz9A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES


(Corynebacterium
glutamicum)
PF01053
(Cys_Met_Meta_PP)
4 SER A 354
TYR A 111
THR A 110
LEU A 146
None
1.16A 2v0zO-5x5hA:
undetectable
2v0zO-5x5hA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron)
no annotation 4 TYR A 333
THR A 524
LEU A 536
THR A 562
None
1.19A 2v0zO-5xfmA:
undetectable
2v0zO-5xfmA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN


(Pisum sativum)
no annotation 4 TYR B 172
SER B 446
PRO B  54
THR B 452
None
None
None
DGD  H 102 ( 4.7A)
1.15A 2v0zO-5xnmB:
undetectable
2v0zO-5xnmB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C)
no annotation 4 TYR 21116
SER 21222
LEU 21175
THR 21216
None
0.96A 2v0zO-5zvs2:
undetectable
2v0zO-5zvs2:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbl NEAMINE TRANSAMINASE
NEON


(Streptomyces
fradiae)
no annotation 4 SER A 217
THR A 218
PRO A 224
THR A 314
None
0.87A 2v0zO-6cblA:
undetectable
2v0zO-6cblA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2


(Saccharomyces
cerevisiae)
no annotation 4 SER B 431
SER B 438
THR B 439
THR B 124
None
1.18A 2v0zO-6f42B:
undetectable
2v0zO-6f42B:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE DELTA
SUBUNIT
ATP SYNTHASE EPSILON
SUBUNIT


(Trypanosoma
brucei)
no annotation 4 SER I  38
SER I  24
THR I  25
LEU H 117
None
1.06A 2v0zO-6f5dI:
undetectable
2v0zO-6f5dI:
11.42