SIMILAR PATTERNS OF AMINO ACIDS FOR 2V0Z_O_C41O1327_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
ALA A 115
PHE A 117
ASP A 215
GLY A 217
 None
 0.62A 2v0zO-1am5A:
43.2		 2v0zO-1am5A:
37.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		5 ASP A  32
GLY A  34
ALA A 115
PHE A 117
ILE A 300
 None
 0.81A 2v0zO-1am5A:
43.2		 2v0zO-1am5A:
37.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		5 ASP A  32
GLY A  34
ASP A 215
GLY A 217
SER A 219
 None
 0.55A 2v0zO-1am5A:
43.2		 2v0zO-1am5A:
37.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		5 ASP A 215
GLY A 217
ASP A  32
GLY A  34
SER A  36
 None
 0.84A 2v0zO-1am5A:
43.2		 2v0zO-1am5A:
37.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		5 ASP A  32
GLY A  34
ASP A 215
GLY A 217
SER A 219
 None
 0.70A 2v0zO-1b5fA:
28.5		 2v0zO-1b5fA:
34.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		5 ASP A  32
GLY A  34
PHE A 117
ASP A 215
GLY A 217
 None
 0.35A 2v0zO-1b5fA:
28.5		 2v0zO-1b5fA:
34.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		5 ASP A 215
GLY A 217
ASP A  32
GLY A  34
SER A  36
 None
 0.72A 2v0zO-1b5fA:
28.5		 2v0zO-1b5fA:
34.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bru ELASTASE

(Sus scrofa) 		PF00089
(Trypsin) 		5 VAL P 213
ASP P 194
GLY P 142
ALA P 183
PHE P 228
 None
 0.83A 2v0zO-1bruP:
undetectable		 2v0zO-1bruP:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		5 ASP E 215
GLY E 217
ASP E  32
GLY E  34
SER E  36
 None
 0.87A 2v0zO-1cziE:
44.5		 2v0zO-1cziE:
36.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		8 GLN E  13
ASP E  32
GLY E  34
ALA E 115
PHE E 117
ASP E 215
GLY E 217
SER E 219
 None
 0.62A 2v0zO-1cziE:
44.5		 2v0zO-1cziE:
36.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		5 GLN E 188
ASP E 215
GLY E 217
ASP E  32
GLY E  34
 None
 0.67A 2v0zO-1cziE:
44.5		 2v0zO-1cziE:
36.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi8 NATURAL KILLER CELL
PROTEASE 1

(Rattus
norvegicus) 		PF00089
(Trypsin) 		5 VAL A 213
ASP A 194
GLY A 142
ALA A 183
PHE A 228
 None
 0.90A 2v0zO-1fi8A:
undetectable		 2v0zO-1fi8A:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		5 ASP A  32
GLY A  34
PHE A 117
ASP A 215
GLY A 217
 None
 0.53A 2v0zO-1g0vA:
43.5		 2v0zO-1g0vA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		5 ASP B  32
GLY B  34
ALA B 115
PHE B 117
GLY B 219
 None
 0.77A 2v0zO-1htrB:
35.3		 2v0zO-1htrB:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		5 ASP B  32
GLY B  34
ASP B 217
GLY B 219
SER B 221
 None
 0.65A 2v0zO-1htrB:
35.3		 2v0zO-1htrB:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		5 ASP B  32
GLY B  34
PHE B 117
ASP B 217
GLY B 219
 None
 0.56A 2v0zO-1htrB:
35.3		 2v0zO-1htrB:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		5 ASP B 217
GLY B 219
ASP B  32
GLY B  34
SER B  36
 None
 0.71A 2v0zO-1htrB:
35.3		 2v0zO-1htrB:
36.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		6 ASP A 218
GLY A 220
VAL A 216
ASP A  32
GLY A  34
SER A  36
 None
 1.06A 2v0zO-1j71A:
35.7		 2v0zO-1j71A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		5 VAL A  30
ASP A  32
GLY A  34
ASP A 218
GLY A 220
 None
 0.46A 2v0zO-1j71A:
35.7		 2v0zO-1j71A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		5 VAL A 216
ASP A 218
GLY A 220
ASP A  32
GLY A  34
 None
 0.63A 2v0zO-1j71A:
35.7		 2v0zO-1j71A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB

(Escherichia
coli) 		PF08501
(Shikimate_dh_N) 		6 GLY A 143
ALA A 164
VAL A 171
GLY A 140
SER A 136
ILE A 199
 None
 1.16A 2v0zO-1o9bA:
undetectable		 2v0zO-1o9bA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		5 ALA A 120
PHE A 122
ASP A 223
GLY A 225
ILE A   7
 None
 0.87A 2v0zO-1qdmA:
42.4		 2v0zO-1qdmA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		6 ASP A  36
GLY A  38
ALA A 120
PHE A 122
ASP A 223
GLY A 225
 None
 0.62A 2v0zO-1qdmA:
42.4		 2v0zO-1qdmA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		5 ASP A  36
GLY A  38
ASP A 223
GLY A 225
SER A 227
 None
 0.58A 2v0zO-1qdmA:
42.4		 2v0zO-1qdmA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		5 ASP A 223
GLY A 225
ASP A  36
GLY A  38
SER A  40
 None
 0.90A 2v0zO-1qdmA:
42.4		 2v0zO-1qdmA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qrp PEPSIN 3A

(Homo sapiens) 		PF00026
(Asp) 		8 VAL E  30
ASP E  32
GLY E  34
ALA E 115
PHE E 117
ASP E 215
GLY E 217
SER E 219
 HH0  E 327 ( 4.7A)
HH0  E 327 (-2.7A)
HH0  E 327 (-4.1A)
None
HH0  E 327 ( 4.8A)
HH0  E 327 (-2.5A)
HH0  E 327 (-3.5A)
HH0  E 327 (-3.0A)
 0.56A 2v0zO-1qrpE:
44.8		 2v0zO-1qrpE:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qs8 PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		5 ASP A  34
GLY A  36
PHE A 120
ASP A 214
GLY A 216
 None
 0.58A 2v0zO-1qs8A:
41.1		 2v0zO-1qs8A:
33.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1

(Saccharomyces
cerevisiae) 		PF00268
(Ribonuc_red_sm) 		5 VAL A 331
ALA A 303
VAL A 334
GLY A 245
ILE A 269
 None
 0.89A 2v0zO-1smqA:
undetectable		 2v0zO-1smqA:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		10 GLN A  13
ASP A  32
GLY A  34
ALA A 115
PHE A 117
VAL A 120
ASP A 215
GLY A 217
SER A 219
ILE A 291
 None
 0.77A 2v0zO-1smrA:
50.8		 2v0zO-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		6 VAL A 213
ASP A 215
GLY A 217
VAL A 300
ASP A  32
GLY A  34
 None
 0.43A 2v0zO-1smrA:
50.8		 2v0zO-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		6 VAL A 213
ASP A 215
VAL A 300
ASP A  32
GLY A  34
ILE A  73
 None
 1.49A 2v0zO-1smrA:
50.8		 2v0zO-1smrA:
69.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqw SACCHAROMYCES
CEREVISIAE NIP7P
HOMOLOG

(Homo sapiens) 		PF03657
(UPF0113) 		5 VAL A 133
GLY A 130
ALA A 103
VAL A  97
GLY A 144
 None
 0.91A 2v0zO-1sqwA:
undetectable		 2v0zO-1sqwA:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tzs CATHEPSIN E

(Homo sapiens) 		PF00026
(Asp) 		7 ASP A  43
GLY A  45
PHE A 128
ASP A 228
GLY A 230
SER A 232
ILE A 307
 None
 0.92A 2v0zO-1tzsA:
42.4		 2v0zO-1tzsA:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tzs CATHEPSIN E

(Homo sapiens) 		PF00026
(Asp) 		5 ASP A 228
GLY A 230
ALA A 311
ASP A  43
GLY A  45
 None
 0.56A 2v0zO-1tzsA:
42.4		 2v0zO-1tzsA:
40.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		5 VAL A 129
ALA A 114
VAL A  25
GLY A 122
ILE A 384
 None
 0.86A 2v0zO-1ua4A:
undetectable		 2v0zO-1ua4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		6 ASP A 218
GLY A 220
ASP A  32
GLY A  34
SER A  36
ILE A 119
 A70  A 500 ( 2.3A)
A70  A 500 (-3.3A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
A70  A 500 (-3.9A)
 1.05A 2v0zO-1zapA:
35.6		 2v0zO-1zapA:
27.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2anl PLASMEPSIN IV

(Plasmodium
malariae) 		PF00026
(Asp) 		6 ASP A  34
GLY A  36
ALA A 118
ASP A 214
GLY A 216
SER A 218
 JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
None
JE2  A3151 (-2.5A)
JE2  A3151 ( 3.9A)
None
 0.58A 2v0zO-2anlA:
39.9		 2v0zO-2anlA:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2anl PLASMEPSIN IV

(Plasmodium
malariae) 		PF00026
(Asp) 		6 ASP A  34
GLY A  36
ALA A 118
PHE A 120
ASP A 214
GLY A 216
 JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
None
None
JE2  A3151 (-2.5A)
JE2  A3151 ( 3.9A)
 1.11A 2v0zO-2anlA:
39.9		 2v0zO-2anlA:
34.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bju PLASMEPSIN II

(Plasmodium
falciparum) 		PF00026
(Asp) 		5 ASP A  34
GLY A  36
ASP A 214
GLY A 216
SER A 218
 IH4  A1330 (-4.2A)
IH4  A1330 ( 4.6A)
IH4  A1330 (-3.3A)
IH4  A1330 ( 4.3A)
IH4  A1331 (-3.9A)
 0.64A 2v0zO-2bjuA:
38.4		 2v0zO-2bjuA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		6 ASP A 241
GLY A 243
VAL A 344
ASP A  48
GLY A  50
SER A  52
 DBO  A1001 (-3.2A)
DBO  A1001 (-4.2A)
None
DBO  A1001 (-2.7A)
DBO  A1001 (-3.7A)
None
 1.18A 2v0zO-2ewyA:
35.4		 2v0zO-2ewyA:
27.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g1s RENIN

(Homo sapiens) 		PF00026
(Asp) 		12 GLN A  14
VAL A  31
ASP A  33
GLY A  35
ALA A 117
PHE A 119
VAL A 122
GLN A 130
ASP A 221
GLY A 223
SER A 225
ILE A 300
 4IG  A 885 (-3.2A)
4IG  A 885 (-4.3A)
4IG  A 885 (-2.7A)
4IG  A 885 (-3.5A)
4IG  A 885 ( 4.6A)
None
4IG  A 885 ( 4.4A)
None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 (-3.1A)
None
 0.49A 2v0zO-2g1sA:
53.2		 2v0zO-2g1sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6t CANDIDAPEPSIN-3

(Candida
albicans) 		PF00026
(Asp) 		5 ASP A 218
GLY A 220
ASP A  32
GLY A  34
SER A  36
 None
 0.78A 2v0zO-2h6tA:
34.4		 2v0zO-2h6tA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6t CANDIDAPEPSIN-3

(Candida
albicans) 		PF00026
(Asp) 		5 VAL A  30
ASP A  32
GLY A  34
ASP A 218
GLY A 220
 None
 0.36A 2v0zO-2h6tA:
34.4		 2v0zO-2h6tA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6x SECRETED CATHEPSIN L
1

(Fasciola
hepatica) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 VAL A 224
GLY A 268
ALA A 308
GLY A 266
ILE A 247
 None
 0.89A 2v0zO-2o6xA:
undetectable		 2v0zO-2o6xA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qae DIHYDROLIPOYL
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 179
GLY A 183
ALA A 194
VAL A 202
GLY A 186
 None
 0.90A 2v0zO-2qaeA:
undetectable		 2v0zO-2qaeA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		6 ASP A 218
GLY A 220
ASP A  32
GLY A  34
SER A  36
ILE A 119
 None
 1.00A 2v0zO-2qzwA:
35.4		 2v0zO-2qzwA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		5 ASP A 218
GLY A 220
ASP A  32
GLY A  34
SER A  36
 None
 0.88A 2v0zO-2qzxA:
35.9		 2v0zO-2qzxA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		6 VAL A 657
GLY A 662
ALA A 727
PHE A 499
GLY A 660
ILE A 632
 None
 1.40A 2v0zO-2vdcA:
undetectable		 2v0zO-2vdcA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8y ENDO-PECTATE LYASE

(Dickeya
chrysanthemi) 		PF03211
(Pectate_lyase) 		6 VAL A 132
GLY A 136
ALA A 125
PHE A 127
VAL A 161
SER A 119
 None
 1.44A 2v0zO-3b8yA:
undetectable		 2v0zO-3b8yA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		5 ASP A  32
GLY A  34
ASP A 215
GLY A 217
ILE A 299
 None
 0.51A 2v0zO-3emyA:
37.8		 2v0zO-3emyA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		5 ASP A 215
GLY A 217
ASP A  32
GLY A  34
SER A  36
 None
 0.84A 2v0zO-3emyA:
37.8		 2v0zO-3emyA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1

(Candida
parapsilosis) 		PF00026
(Asp) 		5 ASP A 220
GLY A 222
ASP A  32
GLY A  34
SER A  36
 None
 0.90A 2v0zO-3fv3A:
35.4		 2v0zO-3fv3A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 VAL A 427
GLY A 339
ALA A 407
PHE A 378
ILE A 541
 None
 0.92A 2v0zO-3gmeA:
undetectable		 2v0zO-3gmeA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4s KCBP INTERACTING
CA2+-BINDING PROTEIN

(Arabidopsis
thaliana) 		PF13833
(EF-hand_8) 		6 GLN E  80
VAL E  83
ASP E  87
GLY E  90
ASP E  91
GLY E  92
 None
None
CA  E 700 (-3.3A)
CA  E 700 ( 4.6A)
CA  E 700 (-3.0A)
None
 1.48A 2v0zO-3h4sE:
undetectable		 2v0zO-3h4sE:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i83 2-DEHYDROPANTOATE
2-REDUCTASE

(Methylococcus
capsulatus) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 VAL A   5
GLY A   9
ALA A  20
VAL A  28
GLY A  12
 None
 0.84A 2v0zO-3i83A:
undetectable		 2v0zO-3i83A:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oag RENIN

(Homo sapiens) 		PF00026
(Asp) 		8 GLN A  19
VAL A  36
ASP A  38
GLY A  40
ALA A 122
PHE A 124
VAL A 127
GLN A 135
 LPQ  A 167 ( 4.4A)
LPQ  A 167 ( 4.5A)
LPQ  A 167 (-2.8A)
LPQ  A 167 (-3.8A)
LPQ  A 167 (-3.6A)
LPQ  A 167 (-4.6A)
LPQ  A 167 (-4.6A)
None
 0.38A 2v0zO-3oagA:
23.7		 2v0zO-3oagA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		5 ASP A  32
GLY A  34
ALA A 115
PHE A 117
GLY A 217
 None
 0.82A 2v0zO-3psgA:
39.2		 2v0zO-3psgA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		5 ASP A  32
GLY A  34
ASP A 215
GLY A 217
SER A 219
 None
 0.73A 2v0zO-3psgA:
39.2		 2v0zO-3psgA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		5 ASP A  32
GLY A  34
PHE A 117
ASP A 215
GLY A 217
 None
 0.56A 2v0zO-3psgA:
39.2		 2v0zO-3psgA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qs1 PLASMEPSIN-1

(Plasmodium
falciparum) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
ALA A 111
ASP A 215
GLY A 217
SER A 219
 006  A 330 (-2.8A)
006  A 330 (-3.2A)
None
006  A 330 (-2.8A)
006  A 330 (-3.4A)
GOL  A 332 ( 2.5A)
 0.78A 2v0zO-3qs1A:
41.0		 2v0zO-3qs1A:
35.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		5 GLY A 701
ALA A 440
ASP A 706
GLY A 703
ILE A 623
 None
None
MG  A1005 ( 4.7A)
None
None
 0.80A 2v0zO-3tlmA:
undetectable		 2v0zO-3tlmA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 180
GLY A 184
ALA A 195
VAL A 203
GLY A 187
 None
 0.87A 2v0zO-3urhA:
undetectable		 2v0zO-3urhA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx6 E1

(Kluyveromyces
marxianus) 		PF16420
(ATG7_N) 		5 GLN A 142
GLY A 108
ALA A 146
SER A 140
ILE A 173
 None
 0.92A 2v0zO-3vx6A:
undetectable		 2v0zO-3vx6A:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		6 GLN A  15
ASP A  34
GLY A  36
ASP A 216
GLY A 218
SER A 220
 None
None
None
GOL  A1334 (-3.5A)
None
None
 1.00A 2v0zO-4aa9A:
39.9		 2v0zO-4aa9A:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		6 GLN A  15
VAL A  32
ASP A  34
GLY A  36
ASP A 216
GLY A 218
 None
None
None
None
GOL  A1334 (-3.5A)
None
 1.13A 2v0zO-4aa9A:
39.9		 2v0zO-4aa9A:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		6 VAL A  32
ASP A  34
GLY A  36
PHE A 119
ASP A 216
GLY A 218
 None
None
None
None
GOL  A1334 (-3.5A)
None
 0.53A 2v0zO-4aa9A:
39.9		 2v0zO-4aa9A:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4amt RENIN

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		6 GLN A 178
ASP A 269
GLY A 271
ASP A  81
GLY A  83
SER A  85
 None
 1.00A 2v0zO-4amtA:
44.0		 2v0zO-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4amt RENIN

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		6 VAL A  79
ASP A  81
ALA A 165
PHE A 167
VAL A 170
GLN A 178
 None
 0.71A 2v0zO-4amtA:
44.0		 2v0zO-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4amt RENIN

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		8 VAL A  79
ASP A  81
GLY A  83
PHE A 167
VAL A 170
GLN A 178
ASP A 269
GLY A 271
 None
 0.66A 2v0zO-4amtA:
44.0		 2v0zO-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4amt RENIN

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		9 VAL A  79
ASP A  81
GLY A  83
VAL A 170
GLN A 178
ASP A 269
GLY A 271
SER A 273
ILE A 348
 None
None
None
None
None
None
None
SO4  A1387 (-3.8A)
None
 0.70A 2v0zO-4amtA:
44.0		 2v0zO-4amtA:
88.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1n 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Clostridium
butyricum) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 VAL A   6
GLY A  10
ALA A  21
VAL A  29
GLY A  13
 None
 0.89A 2v0zO-4r1nA:
undetectable		 2v0zO-4r1nA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcd BETA-SECRETASE 1

(Homo sapiens) 		PF00026
(Asp) 		6 ASP A 228
GLY A 230
VAL A 332
ASP A  32
GLY A  34
SER A  36
 3LL  A 501 (-2.6A)
3LL  A 501 (-3.0A)
None
3LL  A 501 (-2.8A)
3LL  A 501 ( 3.9A)
None
 1.03A 2v0zO-4rcdA:
34.6		 2v0zO-4rcdA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		5 VAL A  30
ASP A  32
GLY A  34
ASP A 211
GLY A 213
 None
 0.27A 2v0zO-4y9wA:
34.6		 2v0zO-4y9wA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		5 VAL A 209
ASP A 211
GLY A 213
ASP A  32
GLY A  34
 None
 0.53A 2v0zO-4y9wA:
34.6		 2v0zO-4y9wA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zas CALS13

(Micromonospora
echinospora) 		PF01041
(DegT_DnrJ_EryC1) 		5 VAL A  56
GLY A  52
PHE A 211
VAL A 213
GLY A  48
 None
 0.84A 2v0zO-4zasA:
undetectable		 2v0zO-4zasA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		5 ASP A  35
GLY A  37
ASP A 219
GLY A 221
ILE A 302
 61P  A 406 (-2.7A)
61P  A 406 ( 4.0A)
61P  A 406 (-2.9A)
61P  A 406 ( 4.1A)
None
 0.66A 2v0zO-5hctA:
37.8		 2v0zO-5hctA:
24.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 5 ASP B  34
GLY B  36
ASP B 214
GLY B 216
SER B 218
 None
 0.30A 2v0zO-5i70B:
41.4		 2v0zO-5i70B:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 5 ASP B  34
GLY B  36
PHE B 120
ASP B 214
SER B 218
 None
 0.69A 2v0zO-5i70B:
41.4		 2v0zO-5i70B:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 5 VAL B 212
ASP B 214
GLY B 216
ASP B  34
GLY B  36
 None
 0.72A 2v0zO-5i70B:
41.4		 2v0zO-5i70B:
33.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 5 ASP A  81
ALA A 165
PHE A 167
VAL A 170
GLY A 268
 None
 0.75A 2v0zO-5mktA:
39.8		 2v0zO-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 6 ASP A  81
GLY A  83
PHE A 167
VAL A 170
ASP A 266
GLY A 268
 None
 0.55A 2v0zO-5mktA:
39.8		 2v0zO-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 6 ASP A  81
GLY A  83
VAL A 170
ASP A 266
GLY A 268
SER A 270
 None
 0.55A 2v0zO-5mktA:
39.8		 2v0zO-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 6 ASP A  81
GLY A 268
VAL A 170
ASP A 266
GLY A  83
ILE A 361
 None
 1.49A 2v0zO-5mktA:
39.8		 2v0zO-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 6 VAL A 264
ASP A 266
GLY A 268
VAL A 355
ASP A  81
GLY A  83
 None
 0.64A 2v0zO-5mktA:
39.8		 2v0zO-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 5 ASP A  81
ALA A 165
PHE A 167
VAL A 170
GLY A 268
 None
 0.69A 2v0zO-5mlgA:
44.9		 2v0zO-5mlgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 6 ASP A  81
GLY A  83
PHE A 167
VAL A 170
ASP A 266
GLY A 268
 None
 0.55A 2v0zO-5mlgA:
44.9		 2v0zO-5mlgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 6 ASP A  81
GLY A  83
VAL A 170
ASP A 266
GLY A 268
SER A 270
 None
 0.61A 2v0zO-5mlgA:
44.9		 2v0zO-5mlgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 6 ASP A  81
GLY A 268
VAL A 170
ASP A 266
GLY A  83
ILE A 361
 None
 1.45A 2v0zO-5mlgA:
44.9		 2v0zO-5mlgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 6 VAL A 264
ASP A 266
GLY A 268
VAL A 355
ASP A  81
GLY A  83
 None
 0.73A 2v0zO-5mlgA:
44.9		 2v0zO-5mlgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 7 ASP A  36
GLY A  38
ALA A 119
PHE A 121
ASP A 227
GLY A 229
SER A 231
 None
 0.66A 2v0zO-5n7qA:
45.2		 2v0zO-5n7qA:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B

(Cynara
cardunculus) 		no annotation 6 ASP A  80
GLY A  82
PHE A 166
ASP A 267
GLY A 269
SER A 271
 None
 0.53A 2v0zO-5nfgA:
44.2		 2v0zO-5nfgA:
39.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		5 ASP A  35
GLY A  37
ASP A 219
GLY A 221
ILE A 302
 None
 0.59A 2v0zO-5p60A:
37.7		 2v0zO-5p60A:
28.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5pep PEPSIN

(Sus scrofa) 		PF00026
(Asp) 		7 ASP A  32
GLY A  34
ALA A 115
PHE A 117
ASP A 215
GLY A 217
SER A 219
 None
 0.64A 2v0zO-5pepA:
44.9		 2v0zO-5pepA:
39.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux4 CATHEPSIN D

(Rattus
norvegicus) 		no annotation 8 GLN A  14
ASP A  33
GLY A  35
ALA A 124
ASP A 226
GLY A 228
SER A 230
ILE A 306
 None
3UT  A 404 (-2.9A)
3UT  A 404 (-3.5A)
None
3UT  A 404 (-2.4A)
3UT  A 404 (-3.1A)
3UT  A 404 ( 3.8A)
None
 0.71A 2v0zO-5ux4A:
47.0		 2v0zO-5ux4A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux4 CATHEPSIN D

(Rattus
norvegicus) 		no annotation 9 GLN A  14
VAL A  31
ASP A  33
GLY A  35
ALA A 124
PHE A 126
ASP A 226
GLY A 228
SER A 230
 None
3UT  A 404 (-4.5A)
3UT  A 404 (-2.9A)
3UT  A 404 (-3.5A)
None
None
3UT  A 404 (-2.4A)
3UT  A 404 (-3.1A)
3UT  A 404 ( 3.8A)
 0.37A 2v0zO-5ux4A:
47.0		 2v0zO-5ux4A:
14.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yid PLASMEPSIN II

(Plasmodium
falciparum) 		no annotation 5 ASP A  36
GLY A  38
ASP A 216
GLY A 218
SER A 220
 K95  A 401 ( 2.6A)
K95  A 401 ( 3.5A)
NA  A 403 ( 1.9A)
K95  A 401 ( 3.6A)
K95  A 401 (-3.3A)
 0.69A 2v0zO-5yidA:
39.4		 2v0zO-5yidA:
36.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys9 ACYL-COENZYME A
OXIDASE 3

(Yarrowia
lipolytica) 		no annotation 6 GLN A 109
ALA A 311
VAL A 316
GLY A 112
SER A 108
ILE A 259
 None
 1.28A 2v0zO-5ys9A:
undetectable		 2v0zO-5ys9A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 5 ASP A  80
GLY A  82
VAL A 188
ASP A 313
GLY A 315
 EQG  A 504 (-2.5A)
EQG  A 504 (-3.0A)
None
EQG  A 504 (-2.1A)
EQG  A 504 (-3.5A)
 0.33A 2v0zO-6c4gA:
34.1		 2v0zO-6c4gA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 5 ASP A 313
GLY A 315
ASP A  80
GLY A  82
SER A  84
 EQG  A 504 (-2.1A)
EQG  A 504 (-3.5A)
EQG  A 504 (-2.5A)
EQG  A 504 (-3.0A)
EDO  A 506 (-3.1A)
 0.82A 2v0zO-6c4gA:
34.1		 2v0zO-6c4gA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ej2 BETA-SECRETASE 1

(Homo sapiens) 		no annotation 6 ASP A 637
GLY A 639
VAL A 741
ASP A 441
GLY A 443
SER A 445
 B7E  A 901 (-2.6A)
B7E  A 901 (-3.8A)
None
B7E  A 901 (-2.9A)
B7E  A 901 ( 3.8A)
None
 1.03A 2v0zO-6ej2A:
34.1		 2v0zO-6ej2A:
13.38