SIMILAR PATTERNS OF AMINO ACIDS FOR 2V0Z_O_C41O1327

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
ALA A 115
PHE A 117
ASP A 215
GLY A 217
 None
 0.62A 2v0zO-1am5A:
43.2		 2v0zO-1am5A:
37.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		5 ASP A  32
GLY A  34
ALA A 115
PHE A 117
ILE A 300
 None
 0.81A 2v0zO-1am5A:
43.2		 2v0zO-1am5A:
37.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		5 ASP A  32
GLY A  34
ASP A 215
GLY A 217
SER A 219
 None
 0.55A 2v0zO-1am5A:
43.2		 2v0zO-1am5A:
37.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		5 ASP A 215
GLY A 217
ASP A  32
GLY A  34
SER A  36
 None
 0.84A 2v0zO-1am5A:
43.2		 2v0zO-1am5A:
37.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		5 ASP A  32
GLY A  34
ASP A 215
GLY A 217
SER A 219
 None
 0.70A 2v0zO-1b5fA:
28.5		 2v0zO-1b5fA:
34.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		5 ASP A  32
GLY A  34
PHE A 117
ASP A 215
GLY A 217
 None
 0.35A 2v0zO-1b5fA:
28.5		 2v0zO-1b5fA:
34.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		5 ASP A 215
GLY A 217
ASP A  32
GLY A  34
SER A  36
 None
 0.72A 2v0zO-1b5fA:
28.5		 2v0zO-1b5fA:
34.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bru ELASTASE

(Sus scrofa) 		PF00089
(Trypsin) 		5 VAL P 213
ASP P 194
GLY P 142
ALA P 183
PHE P 228
 None
 0.83A 2v0zO-1bruP:
undetectable		 2v0zO-1bruP:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		5 ASP E 215
GLY E 217
ASP E  32
GLY E  34
SER E  36
 None
 0.87A 2v0zO-1cziE:
44.5		 2v0zO-1cziE:
36.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		8 GLN E  13
ASP E  32
GLY E  34
ALA E 115
PHE E 117
ASP E 215
GLY E 217
SER E 219
 None
 0.62A 2v0zO-1cziE:
44.5		 2v0zO-1cziE:
36.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		5 GLN E 188
ASP E 215
GLY E 217
ASP E  32
GLY E  34
 None
 0.67A 2v0zO-1cziE:
44.5		 2v0zO-1cziE:
36.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi8 NATURAL KILLER CELL
PROTEASE 1

(Rattus
norvegicus) 		PF00089
(Trypsin) 		5 VAL A 213
ASP A 194
GLY A 142
ALA A 183
PHE A 228
 None
 0.90A 2v0zO-1fi8A:
undetectable		 2v0zO-1fi8A:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		5 ASP A  32
GLY A  34
PHE A 117
ASP A 215
GLY A 217
 None
 0.53A 2v0zO-1g0vA:
43.5		 2v0zO-1g0vA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		5 ASP B  32
GLY B  34
ALA B 115
PHE B 117
GLY B 219
 None
 0.77A 2v0zO-1htrB:
35.3		 2v0zO-1htrB:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		5 ASP B  32
GLY B  34
ASP B 217
GLY B 219
SER B 221
 None
 0.65A 2v0zO-1htrB:
35.3		 2v0zO-1htrB:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		5 ASP B  32
GLY B  34
PHE B 117
ASP B 217
GLY B 219
 None
 0.56A 2v0zO-1htrB:
35.3		 2v0zO-1htrB:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		5 ASP B 217
GLY B 219
ASP B  32
GLY B  34
SER B  36
 None
 0.71A 2v0zO-1htrB:
35.3		 2v0zO-1htrB:
36.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		6 ASP A 218
GLY A 220
VAL A 216
ASP A  32
GLY A  34
SER A  36
 None
 1.06A 2v0zO-1j71A:
35.7		 2v0zO-1j71A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		5 VAL A  30
ASP A  32
GLY A  34
ASP A 218
GLY A 220
 None
 0.46A 2v0zO-1j71A:
35.7		 2v0zO-1j71A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		5 VAL A 216
ASP A 218
GLY A 220
ASP A  32
GLY A  34
 None
 0.63A 2v0zO-1j71A:
35.7		 2v0zO-1j71A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB

(Escherichia
coli) 		PF08501
(Shikimate_dh_N) 		6 GLY A 143
ALA A 164
VAL A 171
GLY A 140
SER A 136
ILE A 199
 None
 1.16A 2v0zO-1o9bA:
undetectable		 2v0zO-1o9bA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		5 ALA A 120
PHE A 122
ASP A 223
GLY A 225
ILE A   7
 None
 0.87A 2v0zO-1qdmA:
42.4		 2v0zO-1qdmA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		6 ASP A  36
GLY A  38
ALA A 120
PHE A 122
ASP A 223
GLY A 225
 None
 0.62A 2v0zO-1qdmA:
42.4		 2v0zO-1qdmA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		5 ASP A  36
GLY A  38
ASP A 223
GLY A 225
SER A 227
 None
 0.58A 2v0zO-1qdmA:
42.4		 2v0zO-1qdmA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		5 ASP A 223
GLY A 225
ASP A  36
GLY A  38
SER A  40
 None
 0.90A 2v0zO-1qdmA:
42.4		 2v0zO-1qdmA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qrp PEPSIN 3A

(Homo sapiens) 		PF00026
(Asp) 		8 VAL E  30
ASP E  32
GLY E  34
ALA E 115
PHE E 117
ASP E 215
GLY E 217
SER E 219
 HH0  E 327 ( 4.7A)
HH0  E 327 (-2.7A)
HH0  E 327 (-4.1A)
None
HH0  E 327 ( 4.8A)
HH0  E 327 (-2.5A)
HH0  E 327 (-3.5A)
HH0  E 327 (-3.0A)
 0.56A 2v0zO-1qrpE:
44.8		 2v0zO-1qrpE:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qs8 PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		5 ASP A  34
GLY A  36
PHE A 120
ASP A 214
GLY A 216
 None
 0.58A 2v0zO-1qs8A:
41.1		 2v0zO-1qs8A:
33.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1

(Saccharomyces
cerevisiae) 		PF00268
(Ribonuc_red_sm) 		5 VAL A 331
ALA A 303
VAL A 334
GLY A 245
ILE A 269
 None
 0.89A 2v0zO-1smqA:
undetectable		 2v0zO-1smqA:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		10 GLN A  13
ASP A  32
GLY A  34
ALA A 115
PHE A 117
VAL A 120
ASP A 215
GLY A 217
SER A 219
ILE A 291
 None
 0.77A 2v0zO-1smrA:
50.8		 2v0zO-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		6 VAL A 213
ASP A 215
GLY A 217
VAL A 300
ASP A  32
GLY A  34
 None
 0.43A 2v0zO-1smrA:
50.8		 2v0zO-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		6 VAL A 213
ASP A 215
VAL A 300
ASP A  32
GLY A  34
ILE A  73
 None
 1.49A 2v0zO-1smrA:
50.8		 2v0zO-1smrA:
69.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqw SACCHAROMYCES
CEREVISIAE NIP7P
HOMOLOG

(Homo sapiens) 		PF03657
(UPF0113) 		5 VAL A 133
GLY A 130
ALA A 103
VAL A  97
GLY A 144
 None
 0.91A 2v0zO-1sqwA:
undetectable		 2v0zO-1sqwA:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tzs CATHEPSIN E

(Homo sapiens) 		PF00026
(Asp) 		7 ASP A  43
GLY A  45
PHE A 128
ASP A 228
GLY A 230
SER A 232
ILE A 307
 None
 0.92A 2v0zO-1tzsA:
42.4		 2v0zO-1tzsA:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tzs CATHEPSIN E

(Homo sapiens) 		PF00026
(Asp) 		5 ASP A 228
GLY A 230
ALA A 311
ASP A  43
GLY A  45
 None
 0.56A 2v0zO-1tzsA:
42.4		 2v0zO-1tzsA:
40.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		5 VAL A 129
ALA A 114
VAL A  25
GLY A 122
ILE A 384
 None
 0.86A 2v0zO-1ua4A:
undetectable		 2v0zO-1ua4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		6 ASP A 218
GLY A 220
ASP A  32
GLY A  34
SER A  36
ILE A 119
 A70  A 500 ( 2.3A)
A70  A 500 (-3.3A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
A70  A 500 (-3.9A)
 1.05A 2v0zO-1zapA:
35.6		 2v0zO-1zapA:
27.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2anl PLASMEPSIN IV

(Plasmodium
malariae) 		PF00026
(Asp) 		6 ASP A  34
GLY A  36
ALA A 118
ASP A 214
GLY A 216
SER A 218
 JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
None
JE2  A3151 (-2.5A)
JE2  A3151 ( 3.9A)
None
 0.58A 2v0zO-2anlA:
39.9		 2v0zO-2anlA:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2anl PLASMEPSIN IV

(Plasmodium
malariae) 		PF00026
(Asp) 		6 ASP A  34
GLY A  36
ALA A 118
PHE A 120
ASP A 214
GLY A 216
 JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
None
None
JE2  A3151 (-2.5A)
JE2  A3151 ( 3.9A)
 1.11A 2v0zO-2anlA:
39.9		 2v0zO-2anlA:
34.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bju PLASMEPSIN II

(Plasmodium
falciparum) 		PF00026
(Asp) 		5 ASP A  34
GLY A  36
ASP A 214
GLY A 216
SER A 218
 IH4  A1330 (-4.2A)
IH4  A1330 ( 4.6A)
IH4  A1330 (-3.3A)
IH4  A1330 ( 4.3A)
IH4  A1331 (-3.9A)
 0.64A 2v0zO-2bjuA:
38.4		 2v0zO-2bjuA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		6 ASP A 241
GLY A 243
VAL A 344
ASP A  48
GLY A  50
SER A  52
 DBO  A1001 (-3.2A)
DBO  A1001 (-4.2A)
None
DBO  A1001 (-2.7A)
DBO  A1001 (-3.7A)
None
 1.18A 2v0zO-2ewyA:
35.4		 2v0zO-2ewyA:
27.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g1s RENIN

(Homo sapiens) 		PF00026
(Asp) 		12 GLN A  14
VAL A  31
ASP A  33
GLY A  35
ALA A 117
PHE A 119
VAL A 122
GLN A 130
ASP A 221
GLY A 223
SER A 225
ILE A 300
 4IG  A 885 (-3.2A)
4IG  A 885 (-4.3A)
4IG  A 885 (-2.7A)
4IG  A 885 (-3.5A)
4IG  A 885 ( 4.6A)
None
4IG  A 885 ( 4.4A)
None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 (-3.1A)
None
 0.49A 2v0zO-2g1sA:
53.2		 2v0zO-2g1sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6t CANDIDAPEPSIN-3

(Candida
albicans) 		PF00026
(Asp) 		5 ASP A 218
GLY A 220
ASP A  32
GLY A  34
SER A  36
 None
 0.78A 2v0zO-2h6tA:
34.4		 2v0zO-2h6tA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6t CANDIDAPEPSIN-3

(Candida
albicans) 		PF00026
(Asp) 		5 VAL A  30
ASP A  32
GLY A  34
ASP A 218
GLY A 220
 None
 0.36A 2v0zO-2h6tA:
34.4		 2v0zO-2h6tA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6x SECRETED CATHEPSIN L
1

(Fasciola
hepatica) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 VAL A 224
GLY A 268
ALA A 308
GLY A 266
ILE A 247
 None
 0.89A 2v0zO-2o6xA:
undetectable		 2v0zO-2o6xA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qae DIHYDROLIPOYL
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 179
GLY A 183
ALA A 194
VAL A 202
GLY A 186
 None
 0.90A 2v0zO-2qaeA:
undetectable		 2v0zO-2qaeA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		6 ASP A 218
GLY A 220
ASP A  32
GLY A  34
SER A  36
ILE A 119
 None
 1.00A 2v0zO-2qzwA:
35.4		 2v0zO-2qzwA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		5 ASP A 218
GLY A 220
ASP A  32
GLY A  34
SER A  36
 None
 0.88A 2v0zO-2qzxA:
35.9		 2v0zO-2qzxA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		6 VAL A 657
GLY A 662
ALA A 727
PHE A 499
GLY A 660
ILE A 632
 None
 1.40A 2v0zO-2vdcA:
undetectable		 2v0zO-2vdcA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8y ENDO-PECTATE LYASE

(Dickeya
chrysanthemi) 		PF03211
(Pectate_lyase) 		6 VAL A 132
GLY A 136
ALA A 125
PHE A 127
VAL A 161
SER A 119
 None
 1.44A 2v0zO-3b8yA:
undetectable		 2v0zO-3b8yA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		5 ASP A  32
GLY A  34
ASP A 215
GLY A 217
ILE A 299
 None
 0.51A 2v0zO-3emyA:
37.8		 2v0zO-3emyA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		5 ASP A 215
GLY A 217
ASP A  32
GLY A  34
SER A  36
 None
 0.84A 2v0zO-3emyA:
37.8		 2v0zO-3emyA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1

(Candida
parapsilosis) 		PF00026
(Asp) 		5 ASP A 220
GLY A 222
ASP A  32
GLY A  34
SER A  36
 None
 0.90A 2v0zO-3fv3A:
35.4		 2v0zO-3fv3A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 VAL A 427
GLY A 339
ALA A 407
PHE A 378
ILE A 541
 None
 0.92A 2v0zO-3gmeA:
undetectable		 2v0zO-3gmeA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4s KCBP INTERACTING
CA2+-BINDING PROTEIN

(Arabidopsis
thaliana) 		PF13833
(EF-hand_8) 		6 GLN E  80
VAL E  83
ASP E  87
GLY E  90
ASP E  91
GLY E  92
 None
None
CA  E 700 (-3.3A)
CA  E 700 ( 4.6A)
CA  E 700 (-3.0A)
None
 1.48A 2v0zO-3h4sE:
undetectable		 2v0zO-3h4sE:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i83 2-DEHYDROPANTOATE
2-REDUCTASE

(Methylococcus
capsulatus) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 VAL A   5
GLY A   9
ALA A  20
VAL A  28
GLY A  12
 None
 0.84A 2v0zO-3i83A:
undetectable		 2v0zO-3i83A:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oag RENIN

(Homo sapiens) 		PF00026
(Asp) 		8 GLN A  19
VAL A  36
ASP A  38
GLY A  40
ALA A 122
PHE A 124
VAL A 127
GLN A 135
 LPQ  A 167 ( 4.4A)
LPQ  A 167 ( 4.5A)
LPQ  A 167 (-2.8A)
LPQ  A 167 (-3.8A)
LPQ  A 167 (-3.6A)
LPQ  A 167 (-4.6A)
LPQ  A 167 (-4.6A)
None
 0.38A 2v0zO-3oagA:
23.7		 2v0zO-3oagA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		5 ASP A  32
GLY A  34
ALA A 115
PHE A 117
GLY A 217
 None
 0.82A 2v0zO-3psgA:
39.2		 2v0zO-3psgA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		5 ASP A  32
GLY A  34
ASP A 215
GLY A 217
SER A 219
 None
 0.73A 2v0zO-3psgA:
39.2		 2v0zO-3psgA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		5 ASP A  32
GLY A  34
PHE A 117
ASP A 215
GLY A 217
 None
 0.56A 2v0zO-3psgA:
39.2		 2v0zO-3psgA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qs1 PLASMEPSIN-1

(Plasmodium
falciparum) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
ALA A 111
ASP A 215
GLY A 217
SER A 219
 006  A 330 (-2.8A)
006  A 330 (-3.2A)
None
006  A 330 (-2.8A)
006  A 330 (-3.4A)
GOL  A 332 ( 2.5A)
 0.78A 2v0zO-3qs1A:
41.0		 2v0zO-3qs1A:
35.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		5 GLY A 701
ALA A 440
ASP A 706
GLY A 703
ILE A 623
 None
None
MG  A1005 ( 4.7A)
None
None
 0.80A 2v0zO-3tlmA:
undetectable		 2v0zO-3tlmA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 180
GLY A 184
ALA A 195
VAL A 203
GLY A 187
 None
 0.87A 2v0zO-3urhA:
undetectable		 2v0zO-3urhA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx6 E1

(Kluyveromyces
marxianus) 		PF16420
(ATG7_N) 		5 GLN A 142
GLY A 108
ALA A 146
SER A 140
ILE A 173
 None
 0.92A 2v0zO-3vx6A:
undetectable		 2v0zO-3vx6A:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		6 GLN A  15
ASP A  34
GLY A  36
ASP A 216
GLY A 218
SER A 220
 None
None
None
GOL  A1334 (-3.5A)
None
None
 1.00A 2v0zO-4aa9A:
39.9		 2v0zO-4aa9A:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		6 GLN A  15
VAL A  32
ASP A  34
GLY A  36
ASP A 216
GLY A 218
 None
None
None
None
GOL  A1334 (-3.5A)
None
 1.13A 2v0zO-4aa9A:
39.9		 2v0zO-4aa9A:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		6 VAL A  32
ASP A  34
GLY A  36
PHE A 119
ASP A 216
GLY A 218
 None
None
None
None
GOL  A1334 (-3.5A)
None
 0.53A 2v0zO-4aa9A:
39.9		 2v0zO-4aa9A:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4amt RENIN

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		6 GLN A 178
ASP A 269
GLY A 271
ASP A  81
GLY A  83
SER A  85
 None
 1.00A 2v0zO-4amtA:
44.0		 2v0zO-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4amt RENIN

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		6 VAL A  79
ASP A  81
ALA A 165
PHE A 167
VAL A 170
GLN A 178
 None
 0.71A 2v0zO-4amtA:
44.0		 2v0zO-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4amt RENIN

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		8 VAL A  79
ASP A  81
GLY A  83
PHE A 167
VAL A 170
GLN A 178
ASP A 269
GLY A 271
 None
 0.66A 2v0zO-4amtA:
44.0		 2v0zO-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4amt RENIN

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		9 VAL A  79
ASP A  81
GLY A  83
VAL A 170
GLN A 178
ASP A 269
GLY A 271
SER A 273
ILE A 348
 None
None
None
None
None
None
None
SO4  A1387 (-3.8A)
None
 0.70A 2v0zO-4amtA:
44.0		 2v0zO-4amtA:
88.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1n 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Clostridium
butyricum) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 VAL A   6
GLY A  10
ALA A  21
VAL A  29
GLY A  13
 None
 0.89A 2v0zO-4r1nA:
undetectable		 2v0zO-4r1nA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcd BETA-SECRETASE 1

(Homo sapiens) 		PF00026
(Asp) 		6 ASP A 228
GLY A 230
VAL A 332
ASP A  32
GLY A  34
SER A  36
 3LL  A 501 (-2.6A)
3LL  A 501 (-3.0A)
None
3LL  A 501 (-2.8A)
3LL  A 501 ( 3.9A)
None
 1.03A 2v0zO-4rcdA:
34.6		 2v0zO-4rcdA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		5 VAL A  30
ASP A  32
GLY A  34
ASP A 211
GLY A 213
 None
 0.27A 2v0zO-4y9wA:
34.6		 2v0zO-4y9wA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		5 VAL A 209
ASP A 211
GLY A 213
ASP A  32
GLY A  34
 None
 0.53A 2v0zO-4y9wA:
34.6		 2v0zO-4y9wA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zas CALS13

(Micromonospora
echinospora) 		PF01041
(DegT_DnrJ_EryC1) 		5 VAL A  56
GLY A  52
PHE A 211
VAL A 213
GLY A  48
 None
 0.84A 2v0zO-4zasA:
undetectable		 2v0zO-4zasA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		5 ASP A  35
GLY A  37
ASP A 219
GLY A 221
ILE A 302
 61P  A 406 (-2.7A)
61P  A 406 ( 4.0A)
61P  A 406 (-2.9A)
61P  A 406 ( 4.1A)
None
 0.66A 2v0zO-5hctA:
37.8		 2v0zO-5hctA:
24.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 5 ASP B  34
GLY B  36
ASP B 214
GLY B 216
SER B 218
 None
 0.30A 2v0zO-5i70B:
41.4		 2v0zO-5i70B:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 5 ASP B  34
GLY B  36
PHE B 120
ASP B 214
SER B 218
 None
 0.69A 2v0zO-5i70B:
41.4		 2v0zO-5i70B:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 5 VAL B 212
ASP B 214
GLY B 216
ASP B  34
GLY B  36
 None
 0.72A 2v0zO-5i70B:
41.4		 2v0zO-5i70B:
33.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 5 ASP A  81
ALA A 165
PHE A 167
VAL A 170
GLY A 268
 None
 0.75A 2v0zO-5mktA:
39.8		 2v0zO-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 6 ASP A  81
GLY A  83
PHE A 167
VAL A 170
ASP A 266
GLY A 268
 None
 0.55A 2v0zO-5mktA:
39.8		 2v0zO-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 6 ASP A  81
GLY A  83
VAL A 170
ASP A 266
GLY A 268
SER A 270
 None
 0.55A 2v0zO-5mktA:
39.8		 2v0zO-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 6 ASP A  81
GLY A 268
VAL A 170
ASP A 266
GLY A  83
ILE A 361
 None
 1.49A 2v0zO-5mktA:
39.8		 2v0zO-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 6 VAL A 264
ASP A 266
GLY A 268
VAL A 355
ASP A  81
GLY A  83
 None
 0.64A 2v0zO-5mktA:
39.8		 2v0zO-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 5 ASP A  81
ALA A 165
PHE A 167
VAL A 170
GLY A 268
 None
 0.69A 2v0zO-5mlgA:
44.9		 2v0zO-5mlgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 6 ASP A  81
GLY A  83
PHE A 167
VAL A 170
ASP A 266
GLY A 268
 None
 0.55A 2v0zO-5mlgA:
44.9		 2v0zO-5mlgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 6 ASP A  81
GLY A  83
VAL A 170
ASP A 266
GLY A 268
SER A 270
 None
 0.61A 2v0zO-5mlgA:
44.9		 2v0zO-5mlgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 6 ASP A  81
GLY A 268
VAL A 170
ASP A 266
GLY A  83
ILE A 361
 None
 1.45A 2v0zO-5mlgA:
44.9		 2v0zO-5mlgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 6 VAL A 264
ASP A 266
GLY A 268
VAL A 355
ASP A  81
GLY A  83
 None
 0.73A 2v0zO-5mlgA:
44.9		 2v0zO-5mlgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 7 ASP A  36
GLY A  38
ALA A 119
PHE A 121
ASP A 227
GLY A 229
SER A 231
 None
 0.66A 2v0zO-5n7qA:
45.2		 2v0zO-5n7qA:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B

(Cynara
cardunculus) 		no annotation 6 ASP A  80
GLY A  82
PHE A 166
ASP A 267
GLY A 269
SER A 271
 None
 0.53A 2v0zO-5nfgA:
44.2		 2v0zO-5nfgA:
39.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		5 ASP A  35
GLY A  37
ASP A 219
GLY A 221
ILE A 302
 None
 0.59A 2v0zO-5p60A:
37.7		 2v0zO-5p60A:
28.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5pep PEPSIN

(Sus scrofa) 		PF00026
(Asp) 		7 ASP A  32
GLY A  34
ALA A 115
PHE A 117
ASP A 215
GLY A 217
SER A 219
 None
 0.64A 2v0zO-5pepA:
44.9		 2v0zO-5pepA:
39.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux4 CATHEPSIN D

(Rattus
norvegicus) 		no annotation 8 GLN A  14
ASP A  33
GLY A  35
ALA A 124
ASP A 226
GLY A 228
SER A 230
ILE A 306
 None
3UT  A 404 (-2.9A)
3UT  A 404 (-3.5A)
None
3UT  A 404 (-2.4A)
3UT  A 404 (-3.1A)
3UT  A 404 ( 3.8A)
None
 0.71A 2v0zO-5ux4A:
47.0		 2v0zO-5ux4A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux4 CATHEPSIN D

(Rattus
norvegicus) 		no annotation 9 GLN A  14
VAL A  31
ASP A  33
GLY A  35
ALA A 124
PHE A 126
ASP A 226
GLY A 228
SER A 230
 None
3UT  A 404 (-4.5A)
3UT  A 404 (-2.9A)
3UT  A 404 (-3.5A)
None
None
3UT  A 404 (-2.4A)
3UT  A 404 (-3.1A)
3UT  A 404 ( 3.8A)
 0.37A 2v0zO-5ux4A:
47.0		 2v0zO-5ux4A:
14.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yid PLASMEPSIN II

(Plasmodium
falciparum) 		no annotation 5 ASP A  36
GLY A  38
ASP A 216
GLY A 218
SER A 220
 K95  A 401 ( 2.6A)
K95  A 401 ( 3.5A)
NA  A 403 ( 1.9A)
K95  A 401 ( 3.6A)
K95  A 401 (-3.3A)
 0.69A 2v0zO-5yidA:
39.4		 2v0zO-5yidA:
36.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys9 ACYL-COENZYME A
OXIDASE 3

(Yarrowia
lipolytica) 		no annotation 6 GLN A 109
ALA A 311
VAL A 316
GLY A 112
SER A 108
ILE A 259
 None
 1.28A 2v0zO-5ys9A:
undetectable		 2v0zO-5ys9A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 5 ASP A  80
GLY A  82
VAL A 188
ASP A 313
GLY A 315
 EQG  A 504 (-2.5A)
EQG  A 504 (-3.0A)
None
EQG  A 504 (-2.1A)
EQG  A 504 (-3.5A)
 0.33A 2v0zO-6c4gA:
34.1		 2v0zO-6c4gA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 5 ASP A 313
GLY A 315
ASP A  80
GLY A  82
SER A  84
 EQG  A 504 (-2.1A)
EQG  A 504 (-3.5A)
EQG  A 504 (-2.5A)
EQG  A 504 (-3.0A)
EDO  A 506 (-3.1A)
 0.82A 2v0zO-6c4gA:
34.1		 2v0zO-6c4gA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ej2 BETA-SECRETASE 1

(Homo sapiens) 		no annotation 6 ASP A 637
GLY A 639
VAL A 741
ASP A 441
GLY A 443
SER A 445
 B7E  A 901 (-2.6A)
B7E  A 901 (-3.8A)
None
B7E  A 901 (-2.9A)
B7E  A 901 ( 3.8A)
None
 1.03A 2v0zO-6ej2A:
34.1		 2v0zO-6ej2A:
13.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		4 TYR A  14
SER A  35
TYR A  75
THR A  77
 None
 0.72A 2v0zO-1b5fA:
28.5		 2v0zO-1b5fA:
34.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 TYR A 312
THR A 293
LEU A 300
THR A 390
 None
 0.97A 2v0zO-1bbuA:
undetectable		 2v0zO-1bbuA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 SER A 577
THR A 576
PRO A 582
THR A 484
 None
 0.97A 2v0zO-1dgjA:
undetectable		 2v0zO-1dgjA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN

(Escherichia
coli) 		PF00899
(ThiF) 		4 TYR B 215
THR B 165
PRO B 148
LEU B 124
 None
 1.16A 2v0zO-1jwaB:
undetectable		 2v0zO-1jwaB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 TYR A 273
TYR A 729
THR A 727
THR A1004
 None
 1.19A 2v0zO-1k32A:
undetectable		 2v0zO-1k32A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 TYR A  88
SER A  89
THR A  90
PRO A 119
 None
 0.76A 2v0zO-1kl7A:
undetectable		 2v0zO-1kl7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 THR B 128
PRO B 150
LEU B 149
THR A  88
 None
 1.11A 2v0zO-1mu2B:
undetectable		 2v0zO-1mu2B:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvl LEUCOCIDIN

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		4 SER A  45
TYR A 118
SER A 117
THR A  50
 None
 1.20A 2v0zO-1pvlA:
undetectable		 2v0zO-1pvlA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmn ALPHA-1-ANTICHYMOTRY
PSIN

(Homo sapiens) 		PF00079
(Serpin) 		4 SER A 178
SER A 314
THR A 313
LEU A 304
 None
 1.14A 2v0zO-1qmnA:
undetectable		 2v0zO-1qmnA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		4 SER A  35
TYR A  75
PRO A 111
THR A 295
 None
 0.60A 2v0zO-1smrA:
50.8		 2v0zO-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		4 TYR A  14
SER A  35
TYR A  75
PRO A 111
 None
 0.46A 2v0zO-1smrA:
50.8		 2v0zO-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		4 TYR A  14
TYR A  75
PRO A 111
LEU A 114
 None
 0.60A 2v0zO-1smrA:
50.8		 2v0zO-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g1s RENIN

(Homo sapiens) 		PF00026
(Asp) 		7 TYR A  15
SER A  36
TYR A  78
SER A  79
THR A  80
PRO A 113
LEU A 116
 None
4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
4IG  A 885 (-3.0A)
4IG  A 885 (-3.5A)
4IG  A 885 (-4.7A)
4IG  A 885 (-3.5A)
 0.64A 2v0zO-2g1sA:
53.2		 2v0zO-2g1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g1s RENIN

(Homo sapiens) 		PF00026
(Asp) 		5 TYR A  15
SER A  36
TYR A  78
SER A  79
THR A 304
 None
4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
4IG  A 885 (-3.0A)
None
 0.65A 2v0zO-2g1sA:
53.2		 2v0zO-2g1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g1s RENIN

(Homo sapiens) 		PF00026
(Asp) 		4 TYR A  16
SER A  36
SER A  79
THR A  80
 None
4IG  A 885 ( 4.8A)
4IG  A 885 (-3.0A)
4IG  A 885 (-3.5A)
 0.90A 2v0zO-2g1sA:
53.2		 2v0zO-2g1sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		4 TYR A 596
SER A 493
THR A 494
PRO A 660
 None
 1.10A 2v0zO-2g28A:
undetectable		 2v0zO-2g28A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE

(Helicobacter
pylori) 		PF00698
(Acyl_transf_1) 		4 TYR A  59
SER A  12
SER A  92
LEU A 113
 None
 1.14A 2v0zO-2h1yA:
undetectable		 2v0zO-2h1yA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hig 6-PHOSPHO-1-FRUCTOKI
NASE

(Trypanosoma
brucei) 		PF00365
(PFK) 		4 SER A 172
THR A 195
LEU A 206
THR A 167
 None
 1.12A 2v0zO-2higA:
undetectable		 2v0zO-2higA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuc ALKALINE PHOSPHATASE

(Antarctic
bacterium TAB5) 		PF00245
(Alk_phosphatase) 		4 TYR B  55
SER B  52
THR B  53
PRO B  61
 None
 1.14A 2v0zO-2iucB:
undetectable		 2v0zO-2iucB:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nul PEPTIDYLPROLYL
ISOMERASE

(Escherichia
coli) 		PF00160
(Pro_isomerase) 		4 SER A  93
THR A  23
LEU A  76
THR A  64
 None
 1.10A 2v0zO-2nulA:
undetectable		 2v0zO-2nulA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		4 TYR A 368
THR A 367
LEU A 225
THR A 351
 TYR  A 368 ( 1.3A)
THR  A 367 ( 0.8A)
LEU  A 225 ( 0.6A)
THR  A 351 ( 0.8A)
 1.09A 2v0zO-2ogsA:
undetectable		 2v0zO-2ogsA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ol8 OUTER SURFACE
PROTEIN A

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		4 SER O  37
SER O 120
THR O 136
THR O  97
 None
 0.92A 2v0zO-2ol8O:
undetectable		 2v0zO-2ol8O:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica) 		PF00781
(DAGK_cat) 		4 SER A 274
THR A 140
LEU A 231
THR A 133
 None
 1.20A 2v0zO-2p1rA:
undetectable		 2v0zO-2p1rA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Aspergillus
oryzae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A  60
THR A  37
LEU A  16
THR A  74
 None
 1.20A 2v0zO-2ps2A:
undetectable		 2v0zO-2ps2A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Escherichia
coli) 		PF01297
(ZnuA) 		4 SER A  31
THR A 154
LEU A 113
THR A  49
 None
 0.97A 2v0zO-2ps3A:
undetectable		 2v0zO-2ps3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp2 UNKNOWN PROTEIN

(Photorhabdus
laumondii) 		PF01823
(MACPF) 		4 TYR A  96
TYR A 158
THR A 157
LEU A 313
 None
 1.02A 2v0zO-2qp2A:
undetectable		 2v0zO-2qp2A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 SER A 363
THR A 339
PRO A 318
LEU A 264
 None
 1.11A 2v0zO-2r9vA:
undetectable		 2v0zO-2r9vA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 SER A  66
TYR A  59
THR A  56
LEU A  31
 None
 0.97A 2v0zO-2vl8A:
undetectable		 2v0zO-2vl8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wok CLAVULANIC ACID
BIOSYNTHESIS
OLIGOPEPTIDE BINDING
PROTEIN 2

(Streptomyces
clavuligerus) 		PF00496
(SBP_bac_5) 		4 TYR A  53
TYR A  70
LEU A  62
THR A 355
 None
GOL  A1561 (-4.5A)
None
None
 1.15A 2v0zO-2wokA:
undetectable		 2v0zO-2wokA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		4 SER A 191
THR A  14
PRO A  13
THR A 304
 None
 0.93A 2v0zO-2xu0A:
undetectable		 2v0zO-2xu0A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 4 TYR A 320
SER A 476
TYR A 536
SER A 535
 None
FAD  A 801 ( 3.7A)
SO4  A 903 ( 4.7A)
None
 0.99A 2v0zO-2yr5A:
undetectable		 2v0zO-2yr5A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		4 SER A 395
THR A 305
PRO A 259
LEU A 336
 None
 1.14A 2v0zO-2z00A:
undetectable		 2v0zO-2z00A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Mesorhizobium
japonicum) 		PF08241
(Methyltransf_11) 		4 SER A 142
PRO A  39
LEU A  44
THR A 196
 None
None
None
EDO  A 243 (-3.0A)
 1.15A 2v0zO-3bkwA:
undetectable		 2v0zO-3bkwA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwx ALPHA/BETA HYDROLASE

(Novosphingobium
aromaticivorans) 		PF12697
(Abhydrolase_6) 		4 SER A 134
SER A 104
PRO A 266
THR A 212
 None
 1.15A 2v0zO-3bwxA:
undetectable		 2v0zO-3bwxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana) 		PF13847
(Methyltransf_31) 		4 SER A 712
SER A 715
THR A 716
LEU A 786
 None
 1.16A 2v0zO-3htxA:
undetectable		 2v0zO-3htxA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k94 THIAMIN
PYROPHOSPHOKINASE

(Geobacillus
thermodenitrificans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 SER A 182
THR A 183
PRO A 156
LEU A 204
 None
 1.05A 2v0zO-3k94A:
undetectable		 2v0zO-3k94A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksw STEROL 14-ALPHA
DEMETHYLASE

(Trypanosoma
cruzi) 		PF00067
(p450) 		4 SER A 296
THR A 295
PRO A 355
THR A 178
 HEM  A 488 ( 4.9A)
VNF  A 490 ( 4.0A)
None
None
 1.10A 2v0zO-3kswA:
undetectable		 2v0zO-3kswA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		4 SER A 393
TYR A 417
PRO A  19
THR A 382
 None
 1.10A 2v0zO-3nvsA:
undetectable		 2v0zO-3nvsA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oag RENIN

(Homo sapiens) 		PF00026
(Asp) 		4 TYR A  20
SER A  41
PRO A 118
LEU A 121
 None
LPQ  A 167 ( 3.9A)
LPQ  A 167 ( 4.4A)
None
 0.61A 2v0zO-3oagA:
23.7		 2v0zO-3oagA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qs1 PLASMEPSIN-1

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 TYR A  15
SER A  35
TYR A  75
SER A  77
 None
006  A 330 (-4.5A)
006  A 330 (-4.3A)
006  A 330 (-2.1A)
 0.93A 2v0zO-3qs1A:
41.0		 2v0zO-3qs1A:
35.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6m PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00160
(Pro_isomerase) 		4 SER A  93
THR A  23
LEU A  76
THR A  64
 None
None
PEG  A 165 ( 4.0A)
None
 1.13A 2v0zO-3s6mA:
undetectable		 2v0zO-3s6mA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 TYR A1162
TYR A1167
LEU A1450
THR A1552
 None
 0.99A 2v0zO-3topA:
undetectable		 2v0zO-3topA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uid PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		PF08327
(AHSA1) 		4 TYR A 113
SER A  88
THR A 114
THR A  81
 None
 1.14A 2v0zO-3uidA:
undetectable		 2v0zO-3uidA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux4 ACID-ACTIVATED UREA
CHANNEL

(Helicobacter
pylori) 		PF02293
(AmiS_UreI) 		4 SER A 108
PRO A 165
LEU A 166
THR A 115
 None
 1.20A 2v0zO-3ux4A:
undetectable		 2v0zO-3ux4A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		4 SER A 349
PRO A 374
LEU A 382
THR A 338
 None
 1.15A 2v0zO-4a0hA:
undetectable		 2v0zO-4a0hA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Zymomonas
mobilis) 		PF00724
(Oxidored_FMN) 		4 SER A 186
THR A 187
PRO A 118
LEU A 178
 None
 1.14A 2v0zO-4a3uA:
undetectable		 2v0zO-4a3uA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ab4 XENOBIOTIC REDUCTASE
B

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		4 SER A 187
THR A 188
PRO A 119
LEU A 179
 None
 1.12A 2v0zO-4ab4A:
undetectable		 2v0zO-4ab4A:
23.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4amt RENIN

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		4 TYR A 126
SER A 127
THR A 128
PRO A 161
 None
 0.89A 2v0zO-4amtA:
44.0		 2v0zO-4amtA:
88.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asc KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF01344
(Kelch_1) 		4 SER A 413
TYR A 415
LEU A 429
THR A 356
 None
 1.19A 2v0zO-4ascA:
undetectable		 2v0zO-4ascA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE

(Trypanosoma
cruzi) 		PF00102
(Y_phosphatase) 		4 SER A 205
TYR A 191
LEU A 122
THR A 211
 None
None
FMT  A1305 (-3.7A)
None
 1.10A 2v0zO-4az1A:
undetectable		 2v0zO-4az1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		4 TYR A 573
SER A 648
THR A 649
THR A 633
 GOL  A1753 (-3.9A)
GOL  A1751 (-2.8A)
GOL  A1751 (-3.9A)
None
 1.21A 2v0zO-4c1oA:
undetectable		 2v0zO-4c1oA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 TYR A 241
SER A 240
THR A 219
LEU A 113
 None
 0.93A 2v0zO-4cgyA:
undetectable		 2v0zO-4cgyA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT

(Vaccinia virus) 		PF03341
(Pox_mRNA-cap) 		4 SER B  32
TYR B 133
LEU B 128
THR B 168
 None
 1.11A 2v0zO-4ckeB:
undetectable		 2v0zO-4ckeB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 SER A 245
PRO A 225
LEU A 226
THR A 255
 HEM  A1374 (-3.3A)
None
None
None
 1.07A 2v0zO-4czpA:
undetectable		 2v0zO-4czpA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
mazei) 		PF01458
(UPF0051) 		4 SER A 192
THR A 220
PRO A 247
LEU A 260
 None
 1.17A 2v0zO-4dn7A:
undetectable		 2v0zO-4dn7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
subtilis) 		PF00268
(Ribonuc_red_sm) 		4 TYR A 105
SER A 106
PRO A  32
LEU A  31
 None
 0.99A 2v0zO-4dr0A:
undetectable		 2v0zO-4dr0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcs VERSATILE PEROXIDASE
VPL2

(Pleurotus
eryngii) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 SER A 230
PRO A 221
LEU A 222
THR A 240
 HEM  A 401 (-3.5A)
None
None
None
 1.09A 2v0zO-4fcsA:
undetectable		 2v0zO-4fcsA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		4 SER A 296
THR A 295
PRO A 355
THR A 178
 HEM  A 501 (-3.2A)
VNT  A 502 ( 3.2A)
HEM  A 501 ( 4.8A)
None
 1.12A 2v0zO-4g3jA:
undetectable		 2v0zO-4g3jA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN

(Dyadobacter
fermentans) 		PF00501
(AMP-binding) 		4 SER A  43
TYR A  86
PRO A 108
THR A 179
 None
 0.99A 2v0zO-4gs5A:
undetectable		 2v0zO-4gs5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4icq AMINOPEPTIDASE PEPS

(Streptococcus
pneumoniae) 		PF02073
(Peptidase_M29) 		4 TYR A 266
SER A 346
LEU A 213
THR A 335
 None
 0.95A 2v0zO-4icqA:
undetectable		 2v0zO-4icqA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig7 UBIQUITIN C-TERMINAL
HYDROLASE 37

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		4 TYR A 262
SER A 139
SER A  87
LEU A  28
 None
 1.08A 2v0zO-4ig7A:
undetectable		 2v0zO-4ig7A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jip GTN REDUCTASE

(Agrobacterium
tumefaciens) 		PF00724
(Oxidored_FMN) 		4 SER A 192
THR A 193
PRO A 119
LEU A 184
 None
 1.19A 2v0zO-4jipA:
undetectable		 2v0zO-4jipA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqb PROTEIN H03A11.1

(Caenorhabditis
elegans) 		PF06702
(Fam20C) 		4 TYR A 343
SER A 415
THR A 416
LEU A 406
 None
 1.17A 2v0zO-4kqbA:
undetectable		 2v0zO-4kqbA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 SER A 203
TYR A 132
LEU A 177
THR A 282
 None
 0.93A 2v0zO-4oqjA:
undetectable		 2v0zO-4oqjA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN

(Streptococcus
pyogenes) 		PF16569
(GramPos_pilinBB) 		4 TYR A 119
TYR A 140
THR A 132
THR A 215
 None
None
None
IOD  A 601 (-3.5A)
 1.03A 2v0zO-4p0dA:
undetectable		 2v0zO-4p0dA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uou FUCOSE-SPECIFIC
LECTIN FLEA

(Aspergillus
fumigatus) 		PF07938
(Fungal_lectin) 		4 TYR A  40
SER A  66
THR A 218
LEU A 283
 None
 1.20A 2v0zO-4uouA:
undetectable		 2v0zO-4uouA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF07034
(ORC3_N) 		4 TYR C 430
TYR C 444
SER C 440
THR C 441
 None
 1.11A 2v0zO-4xgcC:
undetectable		 2v0zO-4xgcC:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 TYR A 571
SER A 568
LEU A 597
THR A 326
 None
 1.19A 2v0zO-4xgtA:
undetectable		 2v0zO-4xgtA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk8 AUTOPHAGY PROTEIN 13

(Schizosaccharomyces
pombe) 		PF10033
(ATG13) 		4 SER B  58
THR B  51
LEU B 174
THR B 113
 None
 0.87A 2v0zO-4yk8B:
undetectable		 2v0zO-4yk8B:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 397
THR A 351
LEU A 319
THR A 423
 None
 1.18A 2v0zO-4z0cA:
undetectable		 2v0zO-4z0cA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		4 SER A 512
PRO A 463
LEU A 466
THR A  59
 None
 1.21A 2v0zO-5a29A:
undetectable		 2v0zO-5a29A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN

(Candidatus
Nitrososphaera
gargensis) 		PF00561
(Abhydrolase_1) 		4 SER A   8
THR A  13
LEU A  88
THR A  69
 None
 1.12A 2v0zO-5a62A:
undetectable		 2v0zO-5a62A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo7 PREDICTED PROTEIN

(Aspergillus
oryzae) 		PF07938
(Fungal_lectin) 		4 TYR A  40
SER A  66
THR A 218
LEU A 278
 SFU  A 405 (-3.1A)
None
None
None
 1.10A 2v0zO-5eo7A:
undetectable		 2v0zO-5eo7A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct) 		PF00291
(PALP) 		4 TYR B 354
SER B 373
LEU B 313
THR B  53
 None
PLP  B 501 (-2.4A)
None
None
 1.16A 2v0zO-5ey5B:
undetectable		 2v0zO-5ey5B:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 SER A 724
THR A 730
LEU A 656
THR A 697
 None
 1.08A 2v0zO-5favA:
undetectable		 2v0zO-5favA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 TYR A 667
SER A 724
LEU A 656
THR A 697
 None
 0.63A 2v0zO-5favA:
undetectable		 2v0zO-5favA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 SER A 396
THR A 372
PRO A 351
LEU A 297
 None
 1.10A 2v0zO-5fl7A:
undetectable		 2v0zO-5fl7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjn LYSINE/ORNITHINE
DECARBOXYLASE

(Selenomonas
ruminantium) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 SER A  26
PRO A 223
LEU A 232
THR A  55
 None
 0.97A 2v0zO-5gjnA:
undetectable		 2v0zO-5gjnA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 4 SER A 520
PRO A 187
LEU A 191
THR A 421
 None
 1.07A 2v0zO-5h7wA:
undetectable		 2v0zO-5h7wA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA

(Caldalkalibacillus
thermarum) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 SER A 362
THR A 338
PRO A 317
LEU A 263
 None
 1.15A 2v0zO-5ik2A:
undetectable		 2v0zO-5ik2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jju UNCHARACTERIZED
PROTEIN RV2837C

(Mycobacterium
tuberculosis) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 SER A 189
SER A 150
THR A 152
LEU A 159
 None
 1.20A 2v0zO-5jjuA:
undetectable		 2v0zO-5jjuA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR B 865
THR B 862
LEU B 829
THR B 763
 None
 1.13A 2v0zO-5kkrB:
undetectable		 2v0zO-5kkrB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		4 TYR A 170
SER A 460
LEU A 272
THR A 106
 None
 1.16A 2v0zO-5lv9A:
undetectable		 2v0zO-5lv9A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m76 LIGHT CHAIN DIMER

(Homo sapiens) 		no annotation 4 SER A 182
TYR A 180
SER A 179
THR A 164
 None
 1.08A 2v0zO-5m76A:
undetectable		 2v0zO-5m76A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 4 SER A 310
THR A 319
LEU A 379
THR A 254
 None
 1.04A 2v0zO-5mktA:
39.8		 2v0zO-5mktA:
9.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5pep PEPSIN

(Sus scrofa) 		PF00026
(Asp) 		4 TYR A  14
SER A  35
TYR A  75
THR A  77
 None
 0.63A 2v0zO-5pepA:
44.9		 2v0zO-5pepA:
39.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta1 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		no annotation 4 TYR A 404
SER A 324
THR A 347
LEU A 413
 None
 1.10A 2v0zO-5ta1A:
undetectable		 2v0zO-5ta1A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u84 ACID CERAMIDASE

(Balaenoptera
acutorostrata) 		no annotation 4 TYR A 280
TYR A 137
LEU A 276
THR A 175
 None
None
I3C  A 412 (-4.7A)
None
 1.11A 2v0zO-5u84A:
undetectable		 2v0zO-5u84A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN

(Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C) 		4 TYR A1272
TYR A1264
THR A1262
LEU A1434
 None
 1.06A 2v0zO-5u89A:
undetectable		 2v0zO-5u89A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium) 		PF02310
(B12-binding) 		4 THR A 142
PRO A 290
LEU A 136
THR A 280
 B12  A 802 ( 4.2A)
None
None
EDO  A 807 (-3.0A)
 1.20A 2v0zO-5ul4A:
undetectable		 2v0zO-5ul4A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 SER A 629
SER A 110
THR A  65
LEU A 120
 None
 1.00A 2v0zO-5um6A:
undetectable		 2v0zO-5um6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usd PEPTIDASE S66

(Bacillus
anthracis) 		PF02016
(Peptidase_S66) 		4 SER A 206
THR A 207
LEU A 116
THR A 237
 None
 0.82A 2v0zO-5usdA:
undetectable		 2v0zO-5usdA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1

(Pseudomonas
aeruginosa) 		PF09611
(Cas_Csy1) 		4 SER A 233
TYR A 235
PRO A 266
LEU A 268
 None
 1.18A 2v0zO-5uz9A:
undetectable		 2v0zO-5uz9A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES

(Corynebacterium
glutamicum) 		PF01053
(Cys_Met_Meta_PP) 		4 SER A 354
TYR A 111
THR A 110
LEU A 146
 None
 1.16A 2v0zO-5x5hA:
undetectable		 2v0zO-5x5hA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 TYR A 333
THR A 524
LEU A 536
THR A 562
 None
 1.19A 2v0zO-5xfmA:
undetectable		 2v0zO-5xfmA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN

(Pisum sativum) 		no annotation 4 TYR B 172
SER B 446
PRO B  54
THR B 452
 None
None
None
DGD  H 102 ( 4.7A)
 1.15A 2v0zO-5xnmB:
undetectable		 2v0zO-5xnmB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 4 TYR 21116
SER 21222
LEU 21175
THR 21216
 None
 0.96A 2v0zO-5zvs2:
undetectable		 2v0zO-5zvs2:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbl NEAMINE TRANSAMINASE
NEON

(Streptomyces
fradiae) 		no annotation 4 SER A 217
THR A 218
PRO A 224
THR A 314
 None
 0.87A 2v0zO-6cblA:
undetectable		 2v0zO-6cblA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 4 SER B 431
SER B 438
THR B 439
THR B 124
 None
 1.18A 2v0zO-6f42B:
undetectable		 2v0zO-6f42B:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE DELTA
SUBUNIT
ATP SYNTHASE EPSILON
SUBUNIT

(Trypanosoma
brucei) 		no annotation 4 SER I  38
SER I  24
THR I  25
LEU H 117
 None
 1.06A 2v0zO-6f5dI:
undetectable		 2v0zO-6f5dI:
11.42