SIMILAR PATTERNS OF AMINO ACIDS FOR 2V0Z_C_C41C1328

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
SER A  35
ASP A 215
GLY A 217
SER A 219
 None
 0.58A 2v0zC-1am5A:
42.7		 2v0zC-1am5A:
37.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
SER A  35
PHE A 117
ASP A 215
GLY A 217
 None
 0.65A 2v0zC-1am5A:
42.7		 2v0zC-1am5A:
37.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		5 ASP A 215
GLY A 217
ASP A  32
GLY A  34
SER A  36
 None
 0.84A 2v0zC-1am5A:
42.7		 2v0zC-1am5A:
37.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
SER A  35
ASP A 215
GLY A 217
SER A 219
 None
 0.68A 2v0zC-1b5fA:
7.5		 2v0zC-1b5fA:
34.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
SER A  35
TYR A  75
GLY A 217
SER A  13
 None
 1.16A 2v0zC-1b5fA:
7.5		 2v0zC-1b5fA:
34.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		7 ASP A  32
GLY A  34
SER A  35
TYR A  75
PHE A 117
ASP A 215
GLY A 217
 None
 0.48A 2v0zC-1b5fA:
7.5		 2v0zC-1b5fA:
34.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		5 ASP A 215
GLY A 217
ASP A  32
GLY A  34
SER A  36
 None
 0.75A 2v0zC-1b5fA:
7.5		 2v0zC-1b5fA:
34.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		5 ASP E 215
GLY E 217
ASP E  32
GLY E  34
SER E  36
 None
 0.87A 2v0zC-1cziE:
43.6		 2v0zC-1cziE:
36.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		9 GLN E  13
ASP E  32
GLY E  34
SER E  35
TYR E  75
PHE E 117
ASP E 215
GLY E 217
SER E 219
 None
 0.62A 2v0zC-1cziE:
43.6		 2v0zC-1cziE:
36.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		5 GLN E 188
ASP E 215
GLY E 217
ASP E  32
GLY E  34
 None
 0.66A 2v0zC-1cziE:
43.6		 2v0zC-1cziE:
36.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
SER A  35
PHE A 117
ASP A 215
GLY A 217
 None
 0.52A 2v0zC-1g0vA:
43.4		 2v0zC-1g0vA:
38.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		5 VAL A 765
GLY A 794
VAL A 738
GLY A 767
SER A 605
 None
FMN  A1030 (-3.5A)
None
FMN  A1030 (-3.5A)
None
 0.91A 2v0zC-1h7wA:
undetectable		 2v0zC-1h7wA:
15.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		6 ASP B  32
GLY B  34
SER B  35
ASP B 217
GLY B 219
SER B 221
 None
 0.62A 2v0zC-1htrB:
35.2		 2v0zC-1htrB:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		6 ASP B  32
GLY B  34
SER B  35
PHE B 117
ASP B 217
GLY B 219
 None
 0.58A 2v0zC-1htrB:
35.2		 2v0zC-1htrB:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		5 ASP B 217
GLY B 219
ASP B  32
GLY B  34
SER B  36
 None
 0.75A 2v0zC-1htrB:
35.2		 2v0zC-1htrB:
36.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ASP A  25
GLY A  27
PRO A  81
ASP A  25
GLY A  27
 A79  A 800 (-2.7A)
A79  A 800 (-3.0A)
A79  A 800 ( 3.9A)
A79  A 800 (-2.8A)
A79  A 800 (-3.0A)
 0.89A 2v0zC-1hvcA:
10.9		 2v0zC-1hvcA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
SER A  35
TYR A  74
ASP A 214
GLY A 216
 ZN  A1457 (-1.9A)
ZN  A1457 (-3.6A)
None
None
ZN  A1457 (-1.9A)
ZN  A1457 ( 3.7A)
 0.42A 2v0zC-1ibqA:
37.2		 2v0zC-1ibqA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		6 ASP A  33
GLY A  35
SER A  36
TYR A  75
ASP A 214
GLY A 216
 None
 0.33A 2v0zC-1izeA:
38.0		 2v0zC-1izeA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		6 ASP A 218
GLY A 220
VAL A 216
ASP A  32
GLY A  34
SER A  36
 None
 1.04A 2v0zC-1j71A:
36.4		 2v0zC-1j71A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		7 VAL A  30
ASP A  32
GLY A  34
SER A  35
TYR A  84
ASP A 218
GLY A 220
 None
 0.56A 2v0zC-1j71A:
36.4		 2v0zC-1j71A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		5 VAL A 216
ASP A 218
GLY A 220
ASP A  32
GLY A  34
 None
 0.64A 2v0zC-1j71A:
36.4		 2v0zC-1j71A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lyb CATHEPSIN D

(Homo sapiens) 		PF00026
(Asp) 		6 GLN A  14
VAL A  31
ASP A  33
GLY A  35
SER A  36
TYR A  78
 None
 0.28A 2v0zC-1lybA:
10.6		 2v0zC-1lybA:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mpp PEPSIN

(Rhizomucor
pusillus) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
SER A  35
TYR A  75
ASP A 215
GLY A 217
 None
 0.32A 2v0zC-1mppA:
37.6		 2v0zC-1mppA:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		6 ASP A  36
GLY A  38
SER A  39
ASP A 223
GLY A 225
SER A 227
 None
 0.65A 2v0zC-1qdmA:
42.2		 2v0zC-1qdmA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		7 ASP A  36
GLY A  38
SER A  39
TYR A  80
PHE A 122
ASP A 223
GLY A 225
 None
 0.79A 2v0zC-1qdmA:
42.2		 2v0zC-1qdmA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		5 ASP A 223
GLY A 225
ASP A  36
GLY A  38
SER A  40
 None
 0.90A 2v0zC-1qdmA:
42.2		 2v0zC-1qdmA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qrp PEPSIN 3A

(Homo sapiens) 		PF00026
(Asp) 		9 VAL E  30
ASP E  32
GLY E  34
SER E  35
TYR E  75
PHE E 117
ASP E 215
GLY E 217
SER E 219
 HH0  E 327 ( 4.7A)
HH0  E 327 (-2.7A)
HH0  E 327 (-4.1A)
HH0  E 327 (-4.1A)
HH0  E 327 (-4.5A)
HH0  E 327 ( 4.8A)
HH0  E 327 (-2.5A)
HH0  E 327 (-3.5A)
HH0  E 327 (-3.0A)
 0.48A 2v0zC-1qrpE:
44.5		 2v0zC-1qrpE:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qs8 PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		7 ASP A  34
GLY A  36
SER A  37
TYR A  77
PHE A 120
ASP A 214
GLY A 216
 None
 0.63A 2v0zC-1qs8A:
41.6		 2v0zC-1qs8A:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		11 GLN A  13
ASP A  32
GLY A  34
SER A  35
TYR A  75
PRO A 111
PHE A 117
VAL A 120
ASP A 215
GLY A 217
SER A 219
 None
 0.41A 2v0zC-1smrA:
51.3		 2v0zC-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		6 VAL A 120
ASP A  32
GLY A  34
PRO A 111
PHE A 117
ASP A 215
 None
 1.48A 2v0zC-1smrA:
51.3		 2v0zC-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		7 VAL A 213
ASP A 215
GLY A 217
SER A 218
VAL A 300
ASP A  32
GLY A  34
 None
 0.58A 2v0zC-1smrA:
51.3		 2v0zC-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tzs CATHEPSIN E

(Homo sapiens) 		PF00026
(Asp) 		8 ASP A  43
GLY A  45
SER A  46
TYR A  86
PHE A 128
ASP A 228
GLY A 230
SER A 232
 None
 0.65A 2v0zC-1tzsA:
41.8		 2v0zC-1tzsA:
40.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uh9 HIZOPUSPEPSIN I

(Rhizopus
microsporus) 		PF00026
(Asp) 		6 ASP A  35
GLY A  37
SER A  38
TYR A  77
ASP A 218
GLY A 220
 None
 0.29A 2v0zC-1uh9A:
40.7		 2v0zC-1uh9A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
SER A  35
TYR A  63
ASP A 212
GLY A 214
 None
 0.32A 2v0zC-1wkrA:
36.9		 2v0zC-1wkrA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
SER A  35
TYR A  84
ASP A 218
GLY A 220
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
A70  A 500 ( 4.5A)
A70  A 500 (-3.8A)
A70  A 500 ( 2.3A)
A70  A 500 (-3.3A)
 0.32A 2v0zC-1zapA:
35.7		 2v0zC-1zapA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		5 ASP A 218
GLY A 220
ASP A  32
GLY A  34
SER A  36
 A70  A 500 ( 2.3A)
A70  A 500 (-3.3A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
 0.90A 2v0zC-1zapA:
35.7		 2v0zC-1zapA:
27.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2anl PLASMEPSIN IV

(Plasmodium
malariae) 		PF00026
(Asp) 		7 ASP A  34
GLY A  36
SER A  37
TYR A  77
ASP A 214
GLY A 216
SER A 218
 JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
None
JE2  A3151 (-3.6A)
JE2  A3151 (-2.5A)
JE2  A3151 ( 3.9A)
None
 0.56A 2v0zC-2anlA:
40.1		 2v0zC-2anlA:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2anl PLASMEPSIN IV

(Plasmodium
malariae) 		PF00026
(Asp) 		7 ASP A  34
GLY A  36
SER A  37
TYR A  77
PHE A 120
ASP A 214
GLY A 216
 JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
None
JE2  A3151 (-3.6A)
None
JE2  A3151 (-2.5A)
JE2  A3151 ( 3.9A)
 0.68A 2v0zC-2anlA:
40.1		 2v0zC-2anlA:
34.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bju PLASMEPSIN II

(Plasmodium
falciparum) 		PF00026
(Asp) 		6 ASP A  34
GLY A  36
SER A  37
ASP A 214
GLY A 216
SER A 218
 IH4  A1330 (-4.2A)
IH4  A1330 ( 4.6A)
IH4  A1330 ( 4.6A)
IH4  A1330 (-3.3A)
IH4  A1330 ( 4.3A)
IH4  A1331 (-3.9A)
 0.57A 2v0zC-2bjuA:
38.7		 2v0zC-2bjuA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		6 ASP A  48
GLY A  50
SER A  51
TYR A  87
ASP A 241
GLY A 243
 DBO  A1001 (-2.7A)
DBO  A1001 (-3.7A)
DBO  A1001 (-4.1A)
DBO  A1001 (-3.8A)
DBO  A1001 (-3.2A)
DBO  A1001 (-4.2A)
 0.39A 2v0zC-2ewyA:
35.1		 2v0zC-2ewyA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		6 ASP A 241
GLY A 243
VAL A 344
ASP A  48
GLY A  50
SER A  52
 DBO  A1001 (-3.2A)
DBO  A1001 (-4.2A)
None
DBO  A1001 (-2.7A)
DBO  A1001 (-3.7A)
None
 1.19A 2v0zC-2ewyA:
35.1		 2v0zC-2ewyA:
27.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g1s RENIN

(Homo sapiens) 		PF00026
(Asp) 		5 ASP A 221
GLY A 223
PRO A 301
ASP A  33
GLY A  35
 4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
None
4IG  A 885 (-2.7A)
4IG  A 885 (-3.5A)
 0.91A 2v0zC-2g1sA:
55.4		 2v0zC-2g1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g1s RENIN

(Homo sapiens) 		PF00026
(Asp) 		12 GLN A  14
VAL A  31
ASP A  33
GLY A  35
SER A  36
TYR A  78
PRO A 113
PHE A 119
VAL A 122
ASP A 221
GLY A 223
SER A 225
 4IG  A 885 (-3.2A)
4IG  A 885 (-4.3A)
4IG  A 885 (-2.7A)
4IG  A 885 (-3.5A)
4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
4IG  A 885 (-4.7A)
None
4IG  A 885 ( 4.4A)
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 (-3.1A)
 0.45A 2v0zC-2g1sA:
55.4		 2v0zC-2g1sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6t CANDIDAPEPSIN-3

(Candida
albicans) 		PF00026
(Asp) 		5 ASP A 218
GLY A 220
ASP A  32
GLY A  34
SER A  36
 None
 0.78A 2v0zC-2h6tA:
34.7		 2v0zC-2h6tA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6t CANDIDAPEPSIN-3

(Candida
albicans) 		PF00026
(Asp) 		7 VAL A  30
ASP A  32
GLY A  34
SER A  35
TYR A  84
ASP A 218
GLY A 220
 None
 0.47A 2v0zC-2h6tA:
34.7		 2v0zC-2h6tA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
SER A  35
PRO A 120
ASP A 218
GLY A 220
 None
 1.16A 2v0zC-2qzwA:
35.6		 2v0zC-2qzwA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
SER A  35
TYR A  84
ASP A 218
GLY A 220
 None
 0.29A 2v0zC-2qzwA:
35.6		 2v0zC-2qzwA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		5 ASP A 218
GLY A 220
ASP A  32
GLY A  34
SER A  36
 None
 0.89A 2v0zC-2qzwA:
35.6		 2v0zC-2qzwA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
SER A  35
TYR A  84
ASP A 218
GLY A 220
 None
 0.36A 2v0zC-2qzxA:
36.0		 2v0zC-2qzxA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		5 ASP A 218
GLY A 220
ASP A  32
GLY A  34
SER A  36
 None
 0.87A 2v0zC-2qzxA:
36.0		 2v0zC-2qzxA:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		6 ASP A  38
GLY A  40
SER A  41
TYR A  82
ASP A 237
GLY A 239
 None
 0.42A 2v0zC-2rmpA:
38.4		 2v0zC-2rmpA:
30.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		6 ASP A  33
GLY A  35
SER A  36
TYR A  75
ASP A 213
GLY A 215
 PP6  A 327 ( 2.7A)
PP6  A 327 (-4.0A)
PP6  A 327 ( 4.0A)
PP6  A 327 (-3.8A)
PP6  A 327 ( 2.5A)
PP6  A 327 (-3.6A)
 0.38A 2v0zC-2wedA:
38.3		 2v0zC-2wedA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
SER A  35
TYR A  75
ASP A 215
GLY A 217
 None
 0.35A 2v0zC-3emyA:
37.7		 2v0zC-3emyA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		5 ASP A 215
GLY A 217
ASP A  32
GLY A  34
SER A  36
 None
 0.83A 2v0zC-3emyA:
37.7		 2v0zC-3emyA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1

(Candida
parapsilosis) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
SER A  35
TYR A  78
ASP A 220
GLY A 222
 None
 0.33A 2v0zC-3fv3A:
36.0		 2v0zC-3fv3A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1

(Candida
parapsilosis) 		PF00026
(Asp) 		5 ASP A 220
GLY A 222
ASP A  32
GLY A  34
SER A  36
 None
 0.88A 2v0zC-3fv3A:
36.0		 2v0zC-3fv3A:
27.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oag RENIN

(Homo sapiens) 		PF00026
(Asp) 		8 GLN A  19
VAL A  36
ASP A  38
GLY A  40
SER A  41
PRO A 118
PHE A 124
VAL A 127
 LPQ  A 167 ( 4.4A)
LPQ  A 167 ( 4.5A)
LPQ  A 167 (-2.8A)
LPQ  A 167 (-3.8A)
LPQ  A 167 ( 3.9A)
LPQ  A 167 ( 4.4A)
LPQ  A 167 (-4.6A)
LPQ  A 167 (-4.6A)
 0.50A 2v0zC-3oagA:
23.6		 2v0zC-3oagA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		7 ASP A  32
GLY A  34
SER A  35
TYR A  75
PHE A 117
ASP A 215
GLY A 217
 None
 0.56A 2v0zC-3psgA:
39.0		 2v0zC-3psgA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qs1 PLASMEPSIN-1

(Plasmodium
falciparum) 		PF00026
(Asp) 		7 ASP A  32
GLY A  34
SER A  35
TYR A  75
ASP A 215
GLY A 217
SER A 219
 006  A 330 (-2.8A)
006  A 330 (-3.2A)
006  A 330 (-4.5A)
006  A 330 (-4.3A)
006  A 330 (-2.8A)
006  A 330 (-3.4A)
GOL  A 332 ( 2.5A)
 0.60A 2v0zC-3qs1A:
41.4		 2v0zC-3qs1A:
35.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		6 ASP A 216
GLY A 218
TYR A  11
ASP A  34
GLY A  36
SER A  38
 GOL  A1334 (-3.5A)
None
GOL  A1334 (-2.9A)
None
None
None
 1.14A 2v0zC-4aa9A:
39.2		 2v0zC-4aa9A:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		7 GLN A  15
ASP A  34
GLY A  36
SER A  37
ASP A 216
GLY A 218
SER A 220
 None
None
None
None
GOL  A1334 (-3.5A)
None
None
 0.98A 2v0zC-4aa9A:
39.2		 2v0zC-4aa9A:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		7 GLN A  15
VAL A  32
ASP A  34
GLY A  36
SER A  37
ASP A 216
GLY A 218
 None
None
None
None
None
GOL  A1334 (-3.5A)
None
 1.15A 2v0zC-4aa9A:
39.2		 2v0zC-4aa9A:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		7 VAL A  32
ASP A  34
GLY A  36
SER A  37
PHE A 119
ASP A 216
GLY A 218
 None
None
None
None
None
GOL  A1334 (-3.5A)
None
 0.54A 2v0zC-4aa9A:
39.2		 2v0zC-4aa9A:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4amt RENIN

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		5 ASP A 269
GLY A 271
PRO A 349
ASP A  81
GLY A  83
 None
 0.87A 2v0zC-4amtA:
44.2		 2v0zC-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4amt RENIN

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		6 GLN A 178
ASP A 269
GLY A 271
ASP A  81
GLY A  83
SER A  85
 None
 1.00A 2v0zC-4amtA:
44.2		 2v0zC-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4amt RENIN

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		8 VAL A  79
ASP A  81
GLY A  83
SER A  84
PHE A 167
VAL A 170
ASP A 269
GLY A 271
 None
 0.62A 2v0zC-4amtA:
44.2		 2v0zC-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4amt RENIN

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		8 VAL A  79
ASP A  81
GLY A  83
SER A  84
VAL A 170
ASP A 269
GLY A 271
SER A 273
 None
None
None
None
None
None
None
SO4  A1387 (-3.8A)
 0.58A 2v0zC-4amtA:
44.2		 2v0zC-4amtA:
88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4amt RENIN

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		6 VAL A  79
ASP A  81
SER A  84
PRO A 161
PHE A 167
VAL A 170
 None
 0.66A 2v0zC-4amtA:
44.2		 2v0zC-4amtA:
88.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehc PE-PGRS FAMILY
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 6 ASP A  36
GLY A  38
SER A  39
VAL A 115
ASP A 189
GLY A 191
 ZN  A 301 (-2.3A)
ZN  A 301 ( 3.9A)
None
None
ZN  A 301 (-2.0A)
ZN  A 301 ( 3.9A)
 0.36A 2v0zC-4ehcA:
5.4		 2v0zC-4ehcA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcd BETA-SECRETASE 1

(Homo sapiens) 		PF00026
(Asp) 		5 ASP A  32
GLY A  34
SER A  35
ASP A 228
GLY A 230
 3LL  A 501 (-2.8A)
3LL  A 501 ( 3.9A)
3LL  A 501 ( 4.3A)
3LL  A 501 (-2.6A)
3LL  A 501 (-3.0A)
 0.32A 2v0zC-4rcdA:
34.5		 2v0zC-4rcdA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcd BETA-SECRETASE 1

(Homo sapiens) 		PF00026
(Asp) 		6 ASP A 228
GLY A 230
VAL A 332
ASP A  32
GLY A  34
SER A  36
 3LL  A 501 (-2.6A)
3LL  A 501 (-3.0A)
None
3LL  A 501 (-2.8A)
3LL  A 501 ( 3.9A)
None
 1.04A 2v0zC-4rcdA:
34.5		 2v0zC-4rcdA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rld ASPARTIC PROTEASE
BLA G 2

(Blattella
germanica) 		PF00026
(Asp) 		5 VAL A  30
ASP A  32
SER A  35
VAL A 120
ASP A 215
 None
 0.66A 2v0zC-4rldA:
37.2		 2v0zC-4rldA:
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		7 VAL A  30
ASP A  32
GLY A  34
SER A  35
TYR A  77
ASP A 211
GLY A 213
 None
 0.39A 2v0zC-4y9wA:
35.1		 2v0zC-4y9wA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		5 VAL A 209
ASP A 211
GLY A 213
ASP A  32
GLY A  34
 None
 0.55A 2v0zC-4y9wA:
35.1		 2v0zC-4y9wA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zas CALS13

(Micromonospora
echinospora) 		PF01041
(DegT_DnrJ_EryC1) 		5 VAL A  56
GLY A  52
PHE A 211
VAL A 213
GLY A  48
 None
 0.80A 2v0zC-4zasA:
undetectable		 2v0zC-4zasA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		6 ASP A  35
GLY A  37
SER A  38
TYR A  79
ASP A 219
GLY A 221
 61P  A 406 (-2.7A)
61P  A 406 ( 4.0A)
None
61P  A 406 (-4.3A)
61P  A 406 (-2.9A)
61P  A 406 ( 4.1A)
 0.28A 2v0zC-5hctA:
38.1		 2v0zC-5hctA:
24.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 7 ASP B  34
GLY B  36
SER B  37
TYR B  77
ASP B 214
GLY B 216
SER B 218
 None
 0.41A 2v0zC-5i70B:
41.7		 2v0zC-5i70B:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 6 ASP B  34
GLY B  36
SER B  37
TYR B  77
PHE B 120
ASP B 214
 None
 0.68A 2v0zC-5i70B:
41.7		 2v0zC-5i70B:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 5 VAL B 212
ASP B 214
GLY B 216
ASP B  34
GLY B  36
 None
 0.73A 2v0zC-5i70B:
41.7		 2v0zC-5i70B:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jod PROPLASMEPSIN IV

(Plasmodium
falciparum) 		PF00026
(Asp) 		5 ASP A  34
GLY A  36
SER A  37
TYR A  77
PHE A 120
 None
 0.88A 2v0zC-5jodA:
35.1		 2v0zC-5jodA:
31.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 8 ASP A  81
GLY A  83
SER A  84
PRO A 161
PHE A 167
VAL A 170
ASP A 266
GLY A 268
 None
 0.63A 2v0zC-5mktA:
39.6		 2v0zC-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 7 ASP A  81
GLY A  83
SER A  84
VAL A 170
ASP A 266
GLY A 268
SER A 270
 None
 0.60A 2v0zC-5mktA:
39.6		 2v0zC-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 7 VAL A 264
ASP A 266
GLY A 268
SER A 269
VAL A 355
ASP A  81
GLY A  83
 None
 0.67A 2v0zC-5mktA:
39.6		 2v0zC-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 8 ASP A  81
GLY A  83
SER A  84
PRO A 161
PHE A 167
VAL A 170
ASP A 266
GLY A 268
 None
 0.71A 2v0zC-5mlgA:
45.6		 2v0zC-5mlgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 6 ASP A  81
GLY A  83
VAL A 170
ASP A 266
GLY A 268
SER A 270
 None
 0.63A 2v0zC-5mlgA:
45.6		 2v0zC-5mlgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 6 VAL A 264
ASP A 266
GLY A 268
VAL A 355
ASP A  81
GLY A  83
 None
 0.75A 2v0zC-5mlgA:
45.6		 2v0zC-5mlgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 8 ASP A  36
GLY A  38
SER A  39
TYR A  79
PHE A 121
ASP A 227
GLY A 229
SER A 231
 None
 0.51A 2v0zC-5n7qA:
45.9		 2v0zC-5n7qA:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B

(Cynara
cardunculus) 		no annotation 7 ASP A  80
GLY A  82
SER A  83
PHE A 166
ASP A 267
GLY A 269
SER A 271
 None
 0.52A 2v0zC-5nfgA:
44.7		 2v0zC-5nfgA:
39.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		6 ASP A  35
GLY A  37
SER A  38
TYR A  79
ASP A 219
GLY A 221
 None
 0.38A 2v0zC-5p60A:
38.1		 2v0zC-5p60A:
28.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5pep PEPSIN

(Sus scrofa) 		PF00026
(Asp) 		8 ASP A  32
GLY A  34
SER A  35
TYR A  75
PHE A 117
ASP A 215
GLY A 217
SER A 219
 None
 0.57A 2v0zC-5pepA:
44.5		 2v0zC-5pepA:
39.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5pep PEPSIN

(Sus scrofa) 		PF00026
(Asp) 		5 ASP A 215
GLY A 217
ASP A  32
GLY A  34
SER A  36
 None
 0.91A 2v0zC-5pepA:
44.5		 2v0zC-5pepA:
39.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux4 CATHEPSIN D

(Rattus
norvegicus) 		no annotation 9 GLN A  14
VAL A  31
ASP A  33
GLY A  35
SER A  36
PHE A 126
ASP A 226
GLY A 228
SER A 230
 None
3UT  A 404 (-4.5A)
3UT  A 404 (-2.9A)
3UT  A 404 (-3.5A)
3UT  A 404 ( 4.5A)
None
3UT  A 404 (-2.4A)
3UT  A 404 (-3.1A)
3UT  A 404 ( 3.8A)
 0.40A 2v0zC-5ux4A:
46.8		 2v0zC-5ux4A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN

(Pyrococcus
horikoshii) 		no annotation 6 VAL A 151
ASP A 134
GLY A 378
SER A 379
PRO A 180
GLY A 132
 None
ACY  A 602 ( 4.5A)
None
None
None
None
 1.39A 2v0zC-5x09A:
undetectable		 2v0zC-5x09A:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yid PLASMEPSIN II

(Plasmodium
falciparum) 		no annotation 7 ASP A  36
GLY A  38
SER A  39
TYR A  79
ASP A 216
GLY A 218
SER A 220
 K95  A 401 ( 2.6A)
K95  A 401 ( 3.5A)
K95  A 401 ( 4.8A)
K95  A 401 (-4.3A)
NA  A 403 ( 1.9A)
K95  A 401 ( 3.6A)
K95  A 401 (-3.3A)
 0.72A 2v0zC-5yidA:
40.1		 2v0zC-5yidA:
36.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yid PLASMEPSIN II

(Plasmodium
falciparum) 		no annotation 5 ASP A  36
GLY A  38
SER A  39
TYR A  79
PHE A 122
 K95  A 401 ( 2.6A)
K95  A 401 ( 3.5A)
K95  A 401 ( 4.8A)
K95  A 401 (-4.3A)
None
 0.77A 2v0zC-5yidA:
40.1		 2v0zC-5yidA:
36.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 7 ASP A  80
GLY A  82
SER A  83
TYR A 139
VAL A 188
ASP A 313
GLY A 315
 EQG  A 504 (-2.5A)
EQG  A 504 (-3.0A)
EQG  A 504 (-4.3A)
EQG  A 504 (-3.2A)
None
EQG  A 504 (-2.1A)
EQG  A 504 (-3.5A)
 0.45A 2v0zC-6c4gA:
33.8		 2v0zC-6c4gA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 5 ASP A 313
GLY A 315
ASP A  80
GLY A  82
SER A  84
 EQG  A 504 (-2.1A)
EQG  A 504 (-3.5A)
EQG  A 504 (-2.5A)
EQG  A 504 (-3.0A)
EDO  A 506 (-3.1A)
 0.86A 2v0zC-6c4gA:
33.8		 2v0zC-6c4gA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 6 ASP A 313
GLY A 315
SER A 316
ASP A  80
GLY A  82
SER A 192
 EQG  A 504 (-2.1A)
EQG  A 504 (-3.5A)
EQG  A 504 (-3.3A)
EQG  A 504 (-2.5A)
EQG  A 504 (-3.0A)
EDO  A 506 (-3.0A)
 1.31A 2v0zC-6c4gA:
33.8		 2v0zC-6c4gA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ej2 BETA-SECRETASE 1

(Homo sapiens) 		no annotation 5 ASP A 441
GLY A 443
SER A 444
ASP A 637
GLY A 639
 B7E  A 901 (-2.9A)
B7E  A 901 ( 3.8A)
B7E  A 901 ( 3.7A)
B7E  A 901 (-2.6A)
B7E  A 901 (-3.8A)
 0.34A 2v0zC-6ej2A:
33.9		 2v0zC-6ej2A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ej2 BETA-SECRETASE 1

(Homo sapiens) 		no annotation 6 ASP A 637
GLY A 639
VAL A 741
ASP A 441
GLY A 443
SER A 445
 B7E  A 901 (-2.6A)
B7E  A 901 (-3.8A)
None
B7E  A 901 (-2.9A)
B7E  A 901 ( 3.8A)
None
 1.04A 2v0zC-6ej2A:
33.9		 2v0zC-6ej2A:
13.38