SIMILAR PATTERNS OF AMINO ACIDS FOR 2V0M_D_KLND1499_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htq GLUTAMINE SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 PHE A  38
SER A 202
PHE A  89
ILE A 241
 None
 1.02A 2v0mD-1htqA:
0.0		 2v0mD-1htqA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 PHE A 276
SER A 313
PHE A 283
ILE A 311
 None
 1.26A 2v0mD-1iidA:
0.0		 2v0mD-1iidA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqp DIPEPTIDYL PEPTIDASE
I

(Rattus
norvegicus) 		PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc) 		4 PHE A 113
SER A 267
PHE A  68
ILE A 281
 None
 1.01A 2v0mD-1jqpA:
0.0		 2v0mD-1jqpA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3b DIPEPTYDIL-PEPTIDASE
I EXCLUSION DOMAIN
DIPEPTYDIL-PEPTIDASE
I LIGHT CHAIN

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc) 		4 PHE A 113
SER B 268
PHE A  68
ILE B 282
 None
 1.02A 2v0mD-1k3bA:
0.0		 2v0mD-1k3bA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg5 ASPARTATE
CARBAMOYLTRANSFERASE

(Sulfolobus
acidocaldarius) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 PHE A  19
PHE A 152
SER A 254
PHE A 174
 None
 1.32A 2v0mD-1pg5A:
0.0		 2v0mD-1pg5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 CYTOCHROME B6
CYTOCHROME B6-F
COMPLEX SUBUNIT 4
CYTOCHROME B6F
COMPLEX SUBUNIT PETG

(Chlamydomonas
reinhardtii) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
PF02529
(PetG) 		4 PHE G  22
PHE B 110
PHE D 133
ILE D 117
 LMG  D 953 (-3.8A)
None
None
None
 1.39A 2v0mD-1q90G:
undetectable		 2v0mD-1q90G:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME

(Campylobacter
jejuni) 		PF01128
(IspD)
PF02542
(YgbB) 		4 PHE A  47
SER A 170
PHE A 107
ILE A 145
 None
 1.16A 2v0mD-1w55A:
undetectable		 2v0mD-1w55A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkb LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 PHE A 162
PHE A 621
PHE A 629
ILE A  38
 None
 1.34A 2v0mD-1wkbA:
undetectable		 2v0mD-1wkbA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 PHE A 162
PHE A 621
PHE A 629
ILE A  38
 None
 1.29A 2v0mD-1wz2A:
undetectable		 2v0mD-1wz2A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xco PHOSPHATE
ACETYLTRANSFERASE

(Bacillus
subtilis) 		PF01515
(PTA_PTB) 		4 PHE A 285
SER A 185
PHE A 243
ILE A 181
 None
 1.21A 2v0mD-1xcoA:
undetectable		 2v0mD-1xcoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE

(Entamoeba
histolytica) 		PF05770
(Ins134_P3_kin) 		4 PHE X 208
SER X 194
PHE X 144
ILE X 177
 None
ADP  X 871 (-2.6A)
None
ADP  X 871 (-4.6A)
 1.39A 2v0mD-1z2oX:
undetectable		 2v0mD-1z2oX:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7d ORNITHINE
AMINOTRANSFERASE

(Plasmodium
yoelii) 		PF00202
(Aminotran_3) 		4 PHE A 325
SER A 336
PHE A  50
ILE A 338
 None
 1.21A 2v0mD-1z7dA:
undetectable		 2v0mD-1z7dA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8e HYPOTHETICAL PROTEIN
YKTB

(Bacillus
subtilis) 		PF06335
(DUF1054) 		4 PHE A 196
PHE A  98
SER A 135
PHE A  75
 None
 1.28A 2v0mD-2a8eA:
undetectable		 2v0mD-2a8eA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0g WINDBEUTEL PROTEIN

(Drosophila
melanogaster) 		PF07749
(ERp29)
PF07912
(ERp29_N) 		4 PHE A1049
PHE A1135
PHE A1111
ILE A1144
 None
 1.39A 2v0mD-2c0gA:
undetectable		 2v0mD-2c0gA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpm PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1)

(Streptococcus
pneumoniae) 		PF02086
(MethyltransfD12) 		4 PHE A 214
PHE A 226
PHE A  43
ILE A 255
 SAM  A 300 ( 4.8A)
None
SAM  A 300 (-4.2A)
None
 1.34A 2v0mD-2dpmA:
undetectable		 2v0mD-2dpmA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyc GALECTIN-4

(Mus musculus) 		PF00337
(Gal-bind_lectin) 		4 PHE A  76
PHE A  46
PHE A 121
ILE A 147
 None
 1.12A 2v0mD-2dycA:
undetectable		 2v0mD-2dycA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9y ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Escherichia
coli) 		PF01039
(Carboxyl_trans) 		4 PHE B 125
SER B 248
PHE B 210
ILE B 260
 None
 1.40A 2v0mD-2f9yB:
undetectable		 2v0mD-2f9yB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00698
(Acyl_transf_1)
PF16197
(KAsynt_C_assoc) 		4 PHE A 553
SER A 714
PHE A 682
ILE A 717
 None
 1.16A 2v0mD-2jfdA:
undetectable		 2v0mD-2jfdA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lba BABP PROTEIN

(Gallus gallus) 		PF14651
(Lipocalin_7) 		4 PHE A  94
SER A 114
PHE A  63
ILE A  21
 CHO  A 201 (-2.9A)
None
CHO  A 201 (-3.1A)
CHO  A 201 ( 4.3A)
 1.33A 2v0mD-2lbaA:
undetectable		 2v0mD-2lbaA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2s PUTATIVE
OXIDOREDUCTASE

(Pectobacterium
atrosepticum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 PHE A 296
SER A 324
PHE A  93
ILE A 325
 None
 1.19A 2v0mD-2p2sA:
undetectable		 2v0mD-2p2sA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrn PROTEASE I

(Deinococcus
radiodurans) 		PF01965
(DJ-1_PfpI) 		4 PHE A 180
SER A  43
PHE A 172
ILE A  49
 None
 1.25A 2v0mD-2vrnA:
undetectable		 2v0mD-2vrnA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 PHE A 553
SER A 714
PHE A 682
ILE A 717
 None
 1.22A 2v0mD-2vz9A:
undetectable		 2v0mD-2vz9A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE

(Vibrio cholerae) 		PF00155
(Aminotran_1_2) 		4 PHE A  96
SER A 315
PHE A 238
ILE A 317
 None
 1.38A 2v0mD-2wk8A:
undetectable		 2v0mD-2wk8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana) 		PF07859
(Abhydrolase_3) 		4 PHE A 251
PHE A 112
SER A  78
ILE A  70
 None
 1.02A 2v0mD-2zsiA:
undetectable		 2v0mD-2zsiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE

(Photobacterium
phosphoreum) 		PF11477
(PM0188) 		4 PHE A 373
SER A 364
PHE A 275
ILE A 345
 None
 1.31A 2v0mD-2zwiA:
undetectable		 2v0mD-2zwiA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN

(Thermosynechococcus
vulcanus) 		PF00124
(Photo_RC)
PF00421
(PSII) 		4 PHE B 363
PHE D 168
SER D 172
PHE D 339
 None
 1.12A 2v0mD-3a0hB:
undetectable		 2v0mD-3a0hB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayn RHODOPSIN

(Todarodes
pacificus) 		PF00001
(7tm_1) 		4 PHE A 188
PHE A 270
SER A  79
PHE A 205
 RET  A1000 (-4.5A)
None
None
RET  A1000 ( 3.8A)
 1.33A 2v0mD-3aynA:
undetectable		 2v0mD-3aynA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		4 PHE A 454
PHE A 301
SER A 534
ILE A 318
 None
 1.40A 2v0mD-3bolA:
undetectable		 2v0mD-3bolA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbk ELASTASE

(Pseudomonas
aeruginosa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 PHE A 248
SER A 134
PHE A 166
ILE A 190
 None
 1.22A 2v0mD-3dbkA:
undetectable		 2v0mD-3dbkA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Plasmodium
vivax) 		PF01182
(Glucosamine_iso) 		4 PHE A 241
SER A  59
PHE A 162
ILE A  89
 None
 1.09A 2v0mD-3e15A:
undetectable		 2v0mD-3e15A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3es5 PUTATIVE CAPSID
PROTEIN

(Penicillium
stoloniferum
virus F) 		no annotation 4 PHE A  77
PHE A 118
SER A 111
ILE A 193
 None
 1.32A 2v0mD-3es5A:
2.0		 2v0mD-3es5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fob BROMOPEROXIDASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 PHE A 168
SER A  65
PHE A  98
ILE A  16
 None
 1.28A 2v0mD-3fobA:
undetectable		 2v0mD-3fobA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		PF01436
(NHL) 		4 PHE A 662
PHE A 606
PHE A 633
ILE A 562
 None
 1.35A 2v0mD-3fw0A:
undetectable		 2v0mD-3fw0A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis) 		PF12741
(SusD-like) 		4 PHE A 321
SER A 431
PHE A 459
ILE A 433
 None
 1.10A 2v0mD-3gzsA:
undetectable		 2v0mD-3gzsA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS

(Bordetella
bronchiseptica) 		no annotation 4 PHE A  94
PHE A  69
PHE A 138
ILE A  80
 None
 1.36A 2v0mD-3hftA:
undetectable		 2v0mD-3hftA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 PHE A 553
SER A 714
PHE A 682
ILE A 717
 None
 1.11A 2v0mD-3hhdA:
undetectable		 2v0mD-3hhdA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8t GALECTIN-4

(Mus musculus) 		PF00337
(Gal-bind_lectin) 		4 PHE A  88
PHE A  58
PHE A 133
ILE A 159
 None
 1.08A 2v0mD-3i8tA:
undetectable		 2v0mD-3i8tA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5

(Homo sapiens) 		PF00443
(UCH)
PF00627
(UBA)
PF02148
(zf-UBP) 		4 PHE A 829
PHE A 345
PHE A 440
ILE A 412
 None
 1.38A 2v0mD-3ihpA:
undetectable		 2v0mD-3ihpA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		4 PHE B 368
PHE B 381
PHE B 351
ILE B 294
 None
 1.27A 2v0mD-3jb9B:
undetectable		 2v0mD-3jb9B:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kf3 INVERTASE

(Schwanniomyces
occidentalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PHE A 183
SER A 113
PHE A 276
ILE A 138
 None
 1.24A 2v0mD-3kf3A:
undetectable		 2v0mD-3kf3A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kij PROBABLE GLUTATHIONE
PEROXIDASE 8

(Homo sapiens) 		PF00255
(GSHPx) 		4 PHE A  47
PHE A 134
PHE A 106
ILE A 187
 None
 1.26A 2v0mD-3kijA:
undetectable		 2v0mD-3kijA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE

(Listeria
monocytogenes) 		PF00563
(EAL) 		4 PHE A 112
PHE A  59
PHE A  37
ILE A 103
 None
 1.25A 2v0mD-3kzpA:
undetectable		 2v0mD-3kzpA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgg ADENOSINE DEAMINASE
CECR1

(Homo sapiens) 		PF00962
(A_deaminase)
PF08451
(A_deaminase_N) 		4 PHE A 289
PHE A 198
SER A 205
ILE A  92
 None
 1.30A 2v0mD-3lggA:
undetectable		 2v0mD-3lggA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1

(Saccharomyces
cerevisiae) 		PF02383
(Syja_N) 		4 PHE X  16
SER X 102
PHE X  61
ILE X 104
 None
 1.36A 2v0mD-3lwtX:
undetectable		 2v0mD-3lwtX:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1a PUTATIVE
DEHYDROGENASE

(Streptomyces
avermitilis) 		PF00106
(adh_short) 		4 PHE A 148
PHE A 184
PHE A 139
ILE A  21
 None
 1.29A 2v0mD-3m1aA:
undetectable		 2v0mD-3m1aA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzb NICKEL-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 PHE A 494
SER A  74
PHE A 196
ILE A 160
 None
 1.32A 2v0mD-3mzbA:
undetectable		 2v0mD-3mzbA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2x UNCHARACTERIZED
PROTEIN YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		4 PHE A 265
PHE A  52
PHE A 147
ILE A  71
 None
MCL  A 174 ( 4.8A)
None
None
 1.40A 2v0mD-3n2xA:
undetectable		 2v0mD-3n2xA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ops MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Paenibacillus
sp. Y412MC10) 		PF13378
(MR_MLE_C) 		4 PHE A  81
PHE A 365
SER A  60
ILE A 287
 None
 1.25A 2v0mD-3opsA:
undetectable		 2v0mD-3opsA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdf DIPEPTIDYL PEPTIDASE
1

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc) 		4 PHE A 113
SER A 268
PHE A  68
ILE A 282
 None
 1.02A 2v0mD-3pdfA:
undetectable		 2v0mD-3pdfA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbo PHOSPHOSERINE
AMINOTRANSFERASE

(Yersinia pestis) 		PF00266
(Aminotran_5) 		4 PHE A 252
PHE A  46
SER A  35
PHE A  71
 None
 1.38A 2v0mD-3qboA:
undetectable		 2v0mD-3qboA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2u METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Staphylococcus
aureus) 		PF00753
(Lactamase_B) 		4 PHE A 142
PHE A   6
PHE A   3
ILE A  39
 None
 1.39A 2v0mD-3r2uA:
undetectable		 2v0mD-3r2uA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 PHE A 343
PHE A 359
PHE A 356
ILE A 427
 None
 1.26A 2v0mD-3redA:
undetectable		 2v0mD-3redA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 PHE A 344
PHE A 359
PHE A 356
ILE A 427
 None
 1.04A 2v0mD-3redA:
undetectable		 2v0mD-3redA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9j MEMBER OF DUF4221
FAMILY

(Bacteroides
vulgatus) 		PF13970
(DUF4221) 		4 PHE A 107
PHE A  57
SER A 112
ILE A 165
 None
None
FMT  A 408 (-4.3A)
FMT  A 408 ( 4.1A)
 1.37A 2v0mD-3s9jA:
undetectable		 2v0mD-3s9jA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tij NUPC FAMILY PROTEIN

(Vibrio cholerae) 		PF01773
(Nucleos_tra2_N)
PF07662
(Nucleos_tra2_C)
PF07670
(Gate) 		4 PHE A  97
PHE A 270
PHE A 333
ILE A 277
 None
DMU  A 422 ( 4.1A)
URI  A 419 (-4.9A)
None
 1.37A 2v0mD-3tijA:
undetectable		 2v0mD-3tijA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwq OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Vibrio cholerae) 		PF00215
(OMPdecase) 		4 PHE A  63
SER A  71
PHE A  58
ILE A 102
 None
XPE  A 233 (-4.1A)
None
None
 1.37A 2v0mD-3uwqA:
undetectable		 2v0mD-3uwqA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vfd SPASTIN

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 PHE A 469
SER A 399
PHE A 501
ILE A 359
 None
 1.21A 2v0mD-3vfdA:
undetectable		 2v0mD-3vfdA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvj OVALBUMIN

(Dromaius
novaehollandiae) 		PF00079
(Serpin) 		4 PHE A 199
PHE A 359
SER A 356
PHE A 365
 None
 1.40A 2v0mD-3vvjA:
undetectable		 2v0mD-3vvjA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayi LIPOPROTEIN GNA1870
CCOMPND 7

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		4 PHE D 222
PHE D 143
SER D 114
PHE D 194
 None
 1.38A 2v0mD-4ayiD:
undetectable		 2v0mD-4ayiD:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 PHE A 235
PHE A  72
PHE A  86
ILE A 296
 None
 1.24A 2v0mD-4bkmA:
undetectable		 2v0mD-4bkmA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx0 PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 PHE A 222
PHE A  72
PHE A  86
ILE A 283
 None
 1.25A 2v0mD-4bx0A:
undetectable		 2v0mD-4bx0A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		4 PHE A 180
PHE A 280
SER A 225
PHE A 209
 None
 1.29A 2v0mD-4conA:
undetectable		 2v0mD-4conA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d51 CYMA

(Klebsiella
oxytoca) 		PF16941
(CymA) 		4 PHE A 324
PHE A  65
PHE A  56
ILE A 111
 None
 1.36A 2v0mD-4d51A:
undetectable		 2v0mD-4d51A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz6 NUCLEOSIDE
DIPHOSPHATE KINASE

(Borreliella
burgdorferi) 		PF00334
(NDK) 		4 PHE A  29
SER A  89
PHE A  80
ILE A  90
 None
 1.14A 2v0mD-4dz6A:
undetectable		 2v0mD-4dz6A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqv INVERTASE 2

(Saccharomyces
cerevisiae) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PHE A 155
SER A  85
PHE A 250
ILE A 110
 None
 1.29A 2v0mD-4eqvA:
undetectable		 2v0mD-4eqvA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esj TYPE-2 RESTRICTION
ENZYME DPNI

(Streptococcus
pneumoniae) 		PF06044
(DpnI) 		4 PHE A 172
SER A 122
PHE A  63
ILE A 123
 None
 1.31A 2v0mD-4esjA:
undetectable		 2v0mD-4esjA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwi ABC-TYPE
DIPEPTIDE/OLIGOPEPTI
DE/NICKEL TRANSPORT
SYSTEM, ATPASE
COMPONENT

(Caldanaerobacter
subterraneus) 		PF00005
(ABC_tran)
PF08352
(oligo_HPY) 		4 PHE B 243
PHE B 210
SER B  35
ILE B  31
 None
 1.36A 2v0mD-4fwiB:
undetectable		 2v0mD-4fwiB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hva CASPASE-6

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 PHE A 288
PHE A 114
SER A 150
PHE A  78
 None
 1.34A 2v0mD-4hvaA:
undetectable		 2v0mD-4hvaA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre NITRITE EXTRUSION
PROTEIN 1

(Escherichia
coli) 		PF07690
(MFS_1) 		4 PHE A 370
PHE A 270
PHE A 147
ILE A 421
 None
None
NO2  A 501 (-3.3A)
GYP  A 502 (-4.6A)
 1.30A 2v0mD-4jreA:
undetectable		 2v0mD-4jreA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3

(Zea mays) 		PF01156
(IU_nuc_hydro) 		4 PHE A 255
PHE A 178
SER A 180
ILE A 133
 None
 1.18A 2v0mD-4kpoA:
undetectable		 2v0mD-4kpoA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 PHE A  31
PHE A  91
PHE A 226
ILE A  86
 None
 1.15A 2v0mD-4lxfA:
undetectable		 2v0mD-4lxfA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		4 PHE A 265
PHE A  52
PHE A 147
ILE A  71
 None
PYR  A 410 (-4.6A)
GXT  A 409 (-4.1A)
None
 1.36A 2v0mD-4oe7A:
undetectable		 2v0mD-4oe7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oem DIPEPTIDYL PEPTIDASE
1 HEAVY CHAIN

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc) 		4 PHE A 113
SER A 268
PHE A  68
ILE A 282
 None
EDO  A 509 (-4.1A)
None
None
 1.05A 2v0mD-4oemA:
undetectable		 2v0mD-4oemA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		4 PHE A 164
PHE A 152
SER A 195
PHE A 229
 None
 1.13A 2v0mD-4p56A:
undetectable		 2v0mD-4p56A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA

(Escherichia
coli) 		PF03611
(EIIC-GAT) 		4 PHE A 276
SER A  74
PHE A 361
ILE A 354
 None
 1.32A 2v0mD-4rp8A:
undetectable		 2v0mD-4rp8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0t ADC-7 BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00144
(Beta-lactamase) 		4 PHE A 170
SER A 165
PHE A  69
ILE A  83
 None
 1.18A 2v0mD-4u0tA:
undetectable		 2v0mD-4u0tA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		4 PHE A 113
SER A 139
PHE A 176
ILE A 142
 None
 1.35A 2v0mD-4wnzA:
undetectable		 2v0mD-4wnzA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ww3 RHODOPSIN

(Todarodes
pacificus) 		PF00001
(7tm_1) 		4 PHE A 188
PHE A 270
SER A  79
PHE A 205
 RET  A 401 (-4.7A)
None
None
RET  A 401 (-3.6A)
 1.26A 2v0mD-4ww3A:
undetectable		 2v0mD-4ww3A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzp GALECTIN-4

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 PHE A  76
PHE A  46
PHE A 121
ILE A 147
 None
 1.05A 2v0mD-4xzpA:
undetectable		 2v0mD-4xzpA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 PHE A  57
SER A 412
PHE A 504
ILE A 400
 FAD  A 601 (-4.5A)
None
FAD  A 601 (-4.2A)
None
 1.39A 2v0mD-4ynuA:
undetectable		 2v0mD-4ynuA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PHE A 464
SER A 487
PHE A 432
ILE A 483
 None
 1.39A 2v0mD-4z0cA:
undetectable		 2v0mD-4z0cA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		4 PHE A1449
SER A1711
PHE A1488
ILE A1469
 None
 0.93A 2v0mD-5a22A:
undetectable		 2v0mD-5a22A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cay ENVELOPE
GLYCOPROTEIN GP120
CORE FROM ST STRAIN
OF HIV-2

(Human
immunodeficiency
virus 2) 		PF00516
(GP120) 		4 PHE G 400
SER G 465
PHE G  94
ILE G 298
 None
 1.30A 2v0mD-5cayG:
undetectable		 2v0mD-5cayG:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dux GALECTIN-4

(Homo sapiens) 		no annotation 4 PHE B  76
PHE B  46
PHE B 121
ILE B 147
 None
 1.07A 2v0mD-5duxB:
undetectable		 2v0mD-5duxB:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h60 TRANSFERASE

(Escherichia
coli) 		no annotation 4 PHE A 126
PHE A 202
SER A 217
PHE A  93
 None
 1.13A 2v0mD-5h60A:
undetectable		 2v0mD-5h60A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 PHE A 252
PHE A 190
PHE A 231
ILE A 144
 None
KCX  A 192 ( 4.0A)
None
None
 1.25A 2v0mD-5hqlA:
undetectable		 2v0mD-5hqlA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hss LINALOOL
DEHYDRATASE/ISOMERAS
E

(Castellaniella
defragrans) 		no annotation 4 PHE A 255
SER A 186
PHE A 221
ILE A 156
 None
 1.34A 2v0mD-5hssA:
undetectable		 2v0mD-5hssA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmc SYNAPTIC VESICLE
GLYCOPROTEIN 2C

(Rattus
norvegicus) 		PF13599
(Pentapeptide_4) 		4 PHE B 562
PHE B 517
PHE B 552
ILE B 483
 None
 1.25A 2v0mD-5jmcB:
undetectable		 2v0mD-5jmcB:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2

(Rhinovirus C) 		PF00073
(Rhv) 		4 PHE A 114
PHE A 181
PHE A 106
ILE C 188
 None
 1.39A 2v0mD-5k0uA:
undetectable		 2v0mD-5k0uA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 PHE A1960
PHE A1938
PHE A1945
ILE A4069
 None
 1.36A 2v0mD-5nugA:
undetectable		 2v0mD-5nugA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opg ENVELOPE
GLYCOPROTEIN GN

(Hantaan
orthohantavirus) 		PF01567
(Hanta_G1) 		4 PHE A  96
PHE A 343
SER A 291
ILE A 319
 None
None
None
NAG  A 407 (-3.7A)
 1.36A 2v0mD-5opgA:
undetectable		 2v0mD-5opgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63) 		PF01600
(Corona_S1)
PF01601
(Corona_S2) 		4 PHE A 563
PHE A 554
PHE A 522
ILE A 507
 None
 1.24A 2v0mD-5szsA:
undetectable		 2v0mD-5szsA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1

(synthetic
construct) 		no annotation 4 PHE A  54
PHE A 102
PHE A 189
ILE A  75
 None
 1.19A 2v0mD-5tdxA:
undetectable		 2v0mD-5tdxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjw RHIZOBIALES-LIKE
PHOSPHATASE 2

(Arabidopsis
thaliana) 		no annotation 4 PHE A  88
SER A 179
PHE A 160
ILE A  63
 None
 1.27A 2v0mD-5vjwA:
undetectable		 2v0mD-5vjwA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqd BETA-GLUCOSIDE
PHOSPHORYLASE BGLX

(unidentified) 		no annotation 4 PHE A 434
PHE A 508
SER A 496
PHE A 511
 None
 1.16A 2v0mD-5vqdA:
undetectable		 2v0mD-5vqdA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1

(Homo sapiens) 		PF15879
(MWFE) 		4 PHE s  56
PHE s 223
SER s 209
ILE s 213
 None
 1.13A 2v0mD-5xtds:
undetectable		 2v0mD-5xtds:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER

(Mycobacterium
tuberculosis) 		no annotation 4 PHE A 217
PHE A 315
SER A 432
ILE A 428
 None
 1.40A 2v0mD-5yk2A:
undetectable		 2v0mD-5yk2A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio harveyi) 		no annotation 4 PHE A  41
PHE A 122
SER A  90
PHE A  57
 None
 1.37A 2v0mD-5yqwA:
undetectable		 2v0mD-5yqwA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 4 PHE 2 773
SER 2 598
PHE 2 708
ILE 2 599
 None
 1.37A 2v0mD-5zvs2:
undetectable		 2v0mD-5zvs2:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
VARIABLE LYMPHOCYTE
RECEPTOR 2

(Danio rerio;
Eptatretus
burgeri;
Petromyzon
marinus) 		no annotation 4 PHE C 104
SER A  26
PHE C  93
ILE A  28
 None
 1.28A 2v0mD-6bxaC:
undetectable		 2v0mD-6bxaC:
9.55