SIMILAR PATTERNS OF AMINO ACIDS FOR 2V0M_D_KLND1498_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME


(Pseudomonas
putida)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 SER A 106
LEU A 328
ILE A 274
ALA A 315
LEU A 358
None
1.35A 2v0mD-1bkhA:
0.0
2v0mD-1bkhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE


(Lactobacillus
casei)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 SER A 198
LEU A 252
ILE A 201
THR A 113
LEU A 117
None
1.38A 2v0mD-1dxyA:
0.0
2v0mD-1dxyA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR


(Equus caballus)
PF00079
(Serpin)
5 SER A  53
LEU A 112
ILE A 188
PHE A 190
ALA A 347
None
1.36A 2v0mD-1hleA:
0.0
2v0mD-1hleA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE


(Homo sapiens)
PF00135
(COesterase)
5 LEU A 234
ALA A 241
ARG A 144
GLU A  43
LEU A 151
None
1.32A 2v0mD-1jmyA:
0.0
2v0mD-1jmyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE


(Methylosinus
trichosporium)
PF02332
(Phenol_Hydrox)
5 LEU D 204
ILE D 193
PHE D 192
ALA D 189
GLU D 460
None
1.27A 2v0mD-1mhzD:
1.4
2v0mD-1mhzD:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1m HYPOTHETICAL PROTEIN
TM0936


(Thermotoga
maritima)
PF01979
(Amidohydro_1)
5 LEU A  62
ALA A  58
THR A  56
ARG A 148
GLU A 151
None
None
None
MET  A5001 (-3.9A)
None
1.24A 2v0mD-1p1mA:
0.0
2v0mD-1p1mA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb8 WBPP

(Pseudomonas
aeruginosa)
PF01370
(Epimerase)
5 ILE A 310
ALA A 314
ARG A   9
GLU A 240
LEU A 248
None
1.29A 2v0mD-1sb8A:
0.0
2v0mD-1sb8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE


(Escherichia
coli)
PF00202
(Aminotran_3)
5 SER A 217
ILE A 205
ALA A 238
THR A 264
ARG A 247
None
1.30A 2v0mD-1szsA:
0.0
2v0mD-1szsA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE


(Rhodotorula
toruloides)
PF00221
(Lyase_aromatic)
5 LEU A 386
ALA A 510
THR A 514
ARG A 166
LEU A 281
None
1.36A 2v0mD-1t6pA:
0.0
2v0mD-1t6pA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE


(Staphylococcus
aureus)
PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C)
5 LEU A 285
ILE A 118
ALA A 114
THR A 278
MET A  54
None
1.39A 2v0mD-1tvzA:
undetectable
2v0mD-1tvzA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ


(Glycine max)
PF00190
(Cupin_1)
5 ARG A 363
LEU A 210
PHE A 481
ALA A 480
LEU A 214
None
1.36A 2v0mD-1uikA:
undetectable
2v0mD-1uikA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6)
PF00680
(RdRP_1)
5 LEU A 497
ILE A 449
ALA A 455
THR A 323
ARG A 507
None
1.25A 2v0mD-1wacA:
undetectable
2v0mD-1wacA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wub CONSERVED
HYPOTHETICAL PROTEIN
TT1927B


(Thermus
thermophilus)
PF04264
(YceI)
5 LEU A 101
ILE A  50
PHE A  82
ALA A  48
GLU A 166
OTP  A1001 ( 4.2A)
None
OTP  A1001 (-4.1A)
OTP  A1001 (-3.6A)
None
1.21A 2v0mD-1wubA:
undetectable
2v0mD-1wubA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN


(Legionella
pneumophila)
PF01369
(Sec7)
5 LEU A  53
ILE A  27
ARG A 109
GLU A  66
LEU A  62
None
1.16A 2v0mD-1xszA:
undetectable
2v0mD-1xszA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A


(Mus musculus)
PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
5 LEU A 282
ILE A 323
ALA A 326
THR A 329
GLU A 454
None
1.12A 2v0mD-1y1uA:
undetectable
2v0mD-1y1uA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abl ABL TYROSINE KINASE

(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
5 SER A 206
ALA A 225
THR A 231
ARG A 171
LEU A 184
None
1.38A 2v0mD-2ablA:
undetectable
2v0mD-2ablA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvm TOXIN B

(Clostridioides
difficile)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
5 SER A 413
ILE A 435
PHE A 446
THR A 464
LEU A 468
None
1.28A 2v0mD-2bvmA:
undetectable
2v0mD-2bvmA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4a MALATE DEHYDROGENASE

(Aeropyrum
pernix)
no annotation 5 SER B 221
ILE B 213
ALA B 209
THR B 206
MET B 171
None
1.39A 2v0mD-2d4aB:
undetectable
2v0mD-2d4aB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkp PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 5


(Homo sapiens)
PF00169
(PH)
5 LEU A  50
ILE A  72
ALA A  89
THR A  96
ARG A  83
None
1.29A 2v0mD-2dkpA:
undetectable
2v0mD-2dkpA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ery RAS-RELATED PROTEIN
R-RAS2


(Homo sapiens)
PF00071
(Ras)
5 LEU A  17
ILE A 123
PHE A 168
ALA A 167
LEU A  30
None
1.29A 2v0mD-2eryA:
undetectable
2v0mD-2eryA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f31 DIAPHANOUS PROTEIN
HOMOLOG 1


(Mus musculus)
PF06345
(Drf_DAD)
PF06367
(Drf_FH3)
PF06371
(Drf_GBD)
5 ARG A 269
LEU B   9
ILE A 222
MET A 274
LEU A 254
None
1.14A 2v0mD-2f31A:
undetectable
2v0mD-2f31A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE


(Escherichia
coli)
PF00698
(Acyl_transf_1)
5 SER A  97
LEU A  44
PHE A  33
GLU A 274
LEU A  19
None
1.26A 2v0mD-2g2oA:
undetectable
2v0mD-2g2oA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5n HYPOTHETICAL PROTEIN
PG_1108


(Porphyromonas
gingivalis)
PF05099
(TerB)
5 ARG A  83
LEU A  91
ILE A  76
ALA A  20
THR A  19
None
1.34A 2v0mD-2h5nA:
undetectable
2v0mD-2h5nA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG


(Thermus
thermophilus)
PF05690
(ThiG)
5 ARG A 119
ALA A  73
THR A  70
GLU A 118
LEU A  97
None
1.33A 2v0mD-2htmA:
undetectable
2v0mD-2htmA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iml HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus)
PF04289
(DUF447)
5 ILE A  15
ALA A  17
THR A  52
ARG A 108
LEU A  56
None
None
FMN  A 200 (-3.7A)
None
None
1.17A 2v0mD-2imlA:
undetectable
2v0mD-2imlA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR


(Burkholderia
pseudomallei)
PF07487
(SopE_GEF)
5 ARG A 129
LEU A 119
PHE A 229
ARG A 142
LEU A 149
None
1.34A 2v0mD-2jokA:
1.8
2v0mD-2jokA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2on5 NA GLUTATHIONE
S-TRANSFERASE 2


(Necator
americanus)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 SER A  72
LEU A 194
ILE A  21
ALA A  25
GLU A  84
None
None
None
EDO  A 428 (-4.3A)
None
1.22A 2v0mD-2on5A:
undetectable
2v0mD-2on5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE


(Xanthomonas
campestris)
PF13419
(HAD_2)
5 LEU A  56
ILE A  98
ALA A  82
THR A  86
LEU A  45
None
1.32A 2v0mD-2pkeA:
undetectable
2v0mD-2pkeA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbp L-ARGININE
BETA-HYDROXYLASE


(Streptomyces
vinaceus)
PF02668
(TauD)
5 ILE A 309
PHE A 308
ALA A 307
ARG A 110
LEU A 121
None
1.05A 2v0mD-2wbpA:
undetectable
2v0mD-2wbpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbp L-ARGININE
BETA-HYDROXYLASE


(Streptomyces
vinaceus)
PF02668
(TauD)
5 LEU A 128
PHE A 308
ALA A 307
ARG A 110
LEU A 121
None
1.14A 2v0mD-2wbpA:
undetectable
2v0mD-2wbpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae)
PF00328
(His_Phos_2)
5 LEU A  22
ILE A 315
ALA A 295
THR A 299
ARG A 366
None
1.23A 2v0mD-2wu0A:
undetectable
2v0mD-2wu0A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2


(Thermus
thermophilus)
PF00034
(Cytochrom_C)
PF00115
(COX1)
PF00116
(COX2)
PF00510
(COX3)
PF02790
(COX2_TM)
5 ILE B 183
PHE B  31
ALA B 170
ARG A 447
GLU B 199
None
None
None
HAS  A1016 ( 3.1A)
MG  A1801 ( 2.6A)
1.20A 2v0mD-2yevB:
undetectable
2v0mD-2yevB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyb HYPOTHETICAL PROTEIN
TTHA1606


(Thermus
thermophilus)
PF01784
(NIF3)
5 ARG A  82
LEU A  28
ALA A  95
GLU A  47
LEU A  61
None
1.31A 2v0mD-2yybA:
undetectable
2v0mD-2yybA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfd CALCINEURIN B-LIKE
PROTEIN 2
PUTATIVE
UNCHARACTERIZED
PROTEIN T20L15_90


(Arabidopsis
thaliana)
PF03822
(NAF)
PF13499
(EF-hand_7)
PF13833
(EF-hand_8)
5 ILE B 316
ALA B 312
THR A 171
ARG A 189
LEU A 191
None
1.31A 2v0mD-2zfdB:
undetectable
2v0mD-2zfdB:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9p CG5977-PA, ISOFORM A

(Drosophila
melanogaster)
PF00004
(AAA)
PF09336
(Vps4_C)
5 LEU A 567
ILE A 581
ALA A 549
THR A 553
LEU A 602
None
1.11A 2v0mD-3b9pA:
undetectable
2v0mD-3b9pA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3v ARACHIN ARAH3
ISOFORM


(Arachis
hypogaea)
PF00190
(Cupin_1)
5 SER A 178
ILE A  92
PHE A 150
GLU A  54
LEU A  75
None
1.30A 2v0mD-3c3vA:
undetectable
2v0mD-3c3vA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egl DEGV FAMILY PROTEIN

(Corynebacterium
glutamicum)
PF02645
(DegV)
5 LEU A 221
ILE A 168
PHE A 189
ALA A 188
GLU A 145
None
None
None
MLY  A 187 ( 3.7A)
None
1.20A 2v0mD-3eglA:
undetectable
2v0mD-3eglA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE


(Pseudomonas
protegens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 SER A 108
LEU A 330
ILE A 276
ALA A 317
LEU A 360
None
1.36A 2v0mD-3fj4A:
undetectable
2v0mD-3fj4A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE


(Pseudomonas
protegens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 SER A 112
LEU A 330
ILE A 276
ALA A 317
THR A 320
None
1.19A 2v0mD-3fj4A:
undetectable
2v0mD-3fj4A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fot 15-O-ACETYLTRANSFERA
SE


(Fusarium
sporotrichioides)
PF07428
(Tri3)
5 LEU A 386
ILE A 292
PHE A 517
ALA A 295
THR A 298
None
1.15A 2v0mD-3fotA:
undetectable
2v0mD-3fotA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE


(Homo sapiens)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C)
5 PHE A 145
ALA A 142
ARG A 165
GLU A 164
LEU A 155
None
None
None
NAG  A 624 ( 4.1A)
None
1.13A 2v0mD-3h55A:
undetectable
2v0mD-3h55A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjv MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE


(Vibrio cholerae)
PF00698
(Acyl_transf_1)
5 SER A 102
LEU A  49
PHE A  38
GLU A 279
LEU A  24
None
1.23A 2v0mD-3hjvA:
undetectable
2v0mD-3hjvA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksc LEGA CLASS

(Pisum sativum)
PF00190
(Cupin_1)
5 SER A 142
ILE A  70
PHE A 114
GLU A  32
LEU A  53
None
1.18A 2v0mD-3kscA:
undetectable
2v0mD-3kscA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mem PUTATIVE SIGNAL
TRANSDUCTION PROTEIN


(Marinobacter
hydrocarbonoclasticus)
PF04073
(tRNA_edit)
PF08668
(HDOD)
5 ARG A 441
LEU A 395
ALA A 286
GLU A 437
LEU A 403
None
1.37A 2v0mD-3memA:
undetectable
2v0mD-3memA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfb BETA-PEPTIDYL
AMINOPEPTIDASE


(Sphingosinicella
xenopeptidilytica)
PF03576
(Peptidase_S58)
5 ARG A 268
LEU A 309
ILE A 313
ALA A 259
THR A 257
None
1.25A 2v0mD-3nfbA:
undetectable
2v0mD-3nfbA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE


(Homo sapiens)
PF03372
(Exo_endo_phos)
5 SER A 237
LEU A 332
ILE A 285
ALA A 329
LEU A 405
None
1.07A 2v0mD-3ngoA:
undetectable
2v0mD-3ngoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7q L-FUCOSE-PROTON
SYMPORTER


(Escherichia
coli)
PF07690
(MFS_1)
5 LEU A 145
ILE A  25
PHE A  28
ALA A  29
LEU A 157
None
1.20A 2v0mD-3o7qA:
undetectable
2v0mD-3o7qA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4


(Saccharomyces
cerevisiae)
PF11701
(UNC45-central)
5 LEU A 714
PHE A 701
ALA A 702
GLU A 739
LEU A 747
None
1.39A 2v0mD-3opbA:
undetectable
2v0mD-3opbA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT


(Komagataella
pastoris)
PF00365
(PFK)
5 SER B 347
ALA B 481
THR B 482
GLU B 724
LEU B 244
None
1.35A 2v0mD-3opyB:
undetectable
2v0mD-3opyB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnz PHOSPHOTRIESTERASE
FAMILY PROTEIN


(Listeria
monocytogenes)
PF02126
(PTE)
5 SER A 186
LEU A 195
ILE A 213
ALA A 233
ARG A 175
None
1.14A 2v0mD-3pnzA:
undetectable
2v0mD-3pnzA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgn ADC OPERON REPRESSOR
ADCR


(Streptococcus
pneumoniae)
PF01047
(MarR)
5 ILE A  72
ALA A  71
THR A  39
GLU A  50
LEU A  61
None
1.35A 2v0mD-3tgnA:
undetectable
2v0mD-3tgnA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9p TYPE 3A
CELLULOSE-BINDING
DOMAIN PROTEIN


(Ruminiclostridium
thermocellum)
PF00942
(CBM_3)
5 SER A  63
LEU A  99
ILE A  65
ALA A  96
THR A  93
None
1.38A 2v0mD-4b9pA:
undetectable
2v0mD-4b9pA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbh PROTEIN SYNTHESIS
INHIBITOR I


(Hordeum vulgare)
PF00161
(RIP)
5 SER A  45
PHE A 236
ALA A 247
ARG A 178
LEU A 216
None
None
None
AMP  A 301 (-3.0A)
None
1.29A 2v0mD-4fbhA:
undetectable
2v0mD-4fbhA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
5 LEU A1013
ILE A1070
ALA A 921
GLU A 993
LEU A 937
None
1.29A 2v0mD-4g34A:
undetectable
2v0mD-4g34A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl0 LMO0810 PROTEIN

(Listeria
monocytogenes)
PF13416
(SBP_bac_8)
5 ILE A 170
ALA A 233
THR A 235
ARG A 177
LEU A 141
None
1.37A 2v0mD-4gl0A:
undetectable
2v0mD-4gl0A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k51 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A


(Saccharomyces
cerevisiae)
PF01399
(PCI)
5 SER A 369
ILE A 370
ALA A 332
THR A 335
LEU A 297
None
1.23A 2v0mD-4k51A:
undetectable
2v0mD-4k51A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans)
PF00343
(Phosphorylase)
5 SER A 490
LEU A 478
ILE A 492
ALA A 587
LEU A 472
None
1.32A 2v0mD-4l22A:
undetectable
2v0mD-4l22A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN


(Paenarthrobacter
aurescens)
PF00378
(ECH_1)
5 ILE A 132
PHE A 131
ALA A 190
GLU A 199
LEU A 205
None
1.31A 2v0mD-4mouA:
undetectable
2v0mD-4mouA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A


(Burkholderia
glumae)
PF05853
(BKACE)
5 LEU A 455
ILE A 397
ALA A 377
GLU A 433
LEU A 465
None
1.25A 2v0mD-4nnbA:
undetectable
2v0mD-4nnbA:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
7 ARG A 105
SER A 119
ILE A 301
ALA A 305
THR A 309
MET A 371
ARG A 372
HEM  A 601 ( 2.8A)
2QH  A 602 (-3.9A)
None
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
None
None
0.59A 2v0mD-4ny4A:
53.0
2v0mD-4ny4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
5 ARG A 105
SER A 119
ILE A 301
PHE A 304
ALA A 305
HEM  A 601 ( 2.8A)
2QH  A 602 (-3.9A)
None
2QH  A 602 (-3.3A)
2QH  A 602 ( 3.6A)
1.06A 2v0mD-4ny4A:
53.0
2v0mD-4ny4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
7 ARG A 105
SER A 119
LEU A 210
ILE A 301
ALA A 305
THR A 309
MET A 371
HEM  A 601 ( 2.8A)
2QH  A 602 (-3.9A)
None
None
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
None
1.03A 2v0mD-4ny4A:
53.0
2v0mD-4ny4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
5 ILE A 301
ALA A 305
THR A 309
MET A 371
GLU A 374
None
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
None
2QH  A 602 ( 4.8A)
0.81A 2v0mD-4ny4A:
53.0
2v0mD-4ny4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8a BIFUNCTIONAL PROTEIN
PUTA


(Escherichia
coli)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg)
5 ILE A 265
ALA A 268
THR A 261
ARG A 253
GLU A 547
None
1.36A 2v0mD-4o8aA:
undetectable
2v0mD-4o8aA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1


(Plasmodium
falciparum)
PF03011
(PFEMP)
PF05424
(Duffy_binding)
5 LEU A1310
ILE A1227
ALA A1303
GLU A1367
LEU A1272
None
1.35A 2v0mD-4p1tA:
undetectable
2v0mD-4p1tA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwu MODULATOR PROTEIN
MZRA


(Klebsiella
pneumoniae)
PF13721
(SecD-TM1)
5 LEU A  94
ILE A  65
ALA A  89
GLU A  36
LEU A 106
None
0.95A 2v0mD-4pwuA:
undetectable
2v0mD-4pwuA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A


(Saccharomyces
cerevisiae)
no annotation 5 SER C 369
ILE C 370
ALA C 332
THR C 335
LEU C 297
None
1.22A 2v0mD-4u1dC:
undetectable
2v0mD-4u1dC:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3A

(Lachancea
kluyveri)
no annotation 5 SER a 369
ILE a 370
ALA a 332
THR a 335
LEU a 297
None
1.18A 2v0mD-4uera:
undetectable
2v0mD-4uera:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN


(Agrobacterium
tumefaciens)
PF00884
(Sulfatase)
PF16347
(DUF4976)
5 LEU A 197
PHE A 218
ALA A  23
ARG A 356
LEU A 305
None
1.02A 2v0mD-4uphA:
undetectable
2v0mD-4uphA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd3 L-AMINO ACID LIGASE

(Bacillus
subtilis)
PF13535
(ATP-grasp_4)
5 ARG A  92
LEU A  64
ILE A   7
THR A  56
LEU A  58
None
1.36A 2v0mD-4wd3A:
undetectable
2v0mD-4wd3A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Streptococcus
suis)
PF01841
(Transglut_core)
5 SER A 243
LEU A 318
PHE A 313
ALA A 312
THR A 308
None
1.37A 2v0mD-4xz7A:
undetectable
2v0mD-4xz7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydj HEAVY CHAIN OF
ANTIBODY 44-VRC13.01
LIGHT CHAIN OF
ANTIBODY 44-VRC13.01


(Homo sapiens)
no annotation 5 ILE H  35
ALA H  93
ARG L  53
GLU H 100
LEU L  46
None
1.36A 2v0mD-4ydjH:
undetectable
2v0mD-4ydjH:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE


(Sinorhizobium
meliloti)
PF06253
(MTTB)
5 LEU A 337
ALA A 286
THR A 290
GLU A  55
LEU A 345
None
1.15A 2v0mD-4yycA:
undetectable
2v0mD-4yycA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens)
PF00079
(Serpin)
5 SER A  30
LEU A 101
ILE A 180
PHE A 182
ALA A 343
None
1.38A 2v0mD-4zk3A:
undetectable
2v0mD-4zk3A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila)
no annotation 5 ARG A 797
LEU A 780
PHE A 777
ALA A 773
GLU A 795
None
1.31A 2v0mD-4zuzA:
undetectable
2v0mD-4zuzA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwp DESIGNED HELICAL
REPEAT PROTEIN


(synthetic
construct)
no annotation 5 ARG A 211
LEU A 135
THR A 141
GLU A 212
LEU A 191
None
1.22A 2v0mD-5cwpA:
undetectable
2v0mD-5cwpA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE


(Deinococcus
radiodurans)
PF01368
(DHH)
PF02272
(DHHA1)
5 ALA A 216
THR A 220
ARG A 184
GLU A  50
LEU A 187
None
1.30A 2v0mD-5f56A:
undetectable
2v0mD-5f56A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqq HEME-BINDING PROTEIN
2


(Homo sapiens)
PF04832
(SOUL)
5 LEU A  69
ILE A  62
PHE A  66
GLU A 191
LEU A 185
None
1.12A 2v0mD-5gqqA:
undetectable
2v0mD-5gqqA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7


(synthetic
construct)
PF12796
(Ank_2)
5 LEU A  23
ILE A  16
ALA A  17
GLU A  46
LEU A  56
None
1.17A 2v0mD-5hs0A:
undetectable
2v0mD-5hs0A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idj CELL CYCLE HISTIDINE
KINASE CCKA


(Caulobacter
vibrioides)
PF00512
(HisKA)
PF02518
(HATPase_c)
5 LEU A 388
ILE A 475
THR A 408
ARG A 436
LEU A 396
None
1.36A 2v0mD-5idjA:
undetectable
2v0mD-5idjA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbh 30S RIBOSOMAL
PROTEIN US7


(Pyrococcus
abyssi)
PF00177
(Ribosomal_S7)
5 ILE H 111
PHE H 108
ALA H 107
ARG H 163
LEU H  67
None
None
None
U  21336 ( 4.4A)
None
1.19A 2v0mD-5jbhH:
undetectable
2v0mD-5jbhH:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqp GLUCOSIDASE 2
SUBUNIT BETA-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF12999
(PRKCSH-like)
5 SER B  49
LEU B  88
ILE B  50
THR B 101
LEU B  92
None
1.34A 2v0mD-5jqpB:
undetectable
2v0mD-5jqpB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr9 NEQ131

(Nanoarchaeum
equitans)
PF01997
(Translin)
5 LEU B 148
ILE B 172
MET B  40
GLU B 129
LEU B  89
None
1.35A 2v0mD-5jr9B:
undetectable
2v0mD-5jr9B:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfd ALLANTOIN RACEMASE

(Pseudomonas
fluorescens)
no annotation 5 ILE A  18
ALA A 184
MET A 144
GLU A  45
LEU A 149
None
1.26A 2v0mD-5lfdA:
undetectable
2v0mD-5lfdA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN7


(Saccharomyces
cerevisiae)
PF01399
(PCI)
PF10602
(RPN7)
5 SER R 254
ILE R 289
ALA R 285
THR R 283
GLU R 275
None
1.26A 2v0mD-5mpdR:
undetectable
2v0mD-5mpdR:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2


(Sus scrofa)
no annotation 5 LEU A 356
ILE A 348
ARG A 334
GLU A 731
LEU A 734
None
None
None
K  A1005 (-2.9A)
None
1.25A 2v0mD-5mpmA:
2.4
2v0mD-5mpmA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C)
5 SER A1333
LEU A1313
ILE A1363
ALA A1367
LEU A1373
None
1.22A 2v0mD-5t8vA:
undetectable
2v0mD-5t8vA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf4 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]


(Bartonella
henselae)
PF13561
(adh_short_C2)
5 SER A 123
LEU A 104
ALA A 199
THR A 197
GLU A 170
None
None
NAD  A 300 (-3.2A)
NAD  A 300 (-2.8A)
None
1.24A 2v0mD-5tf4A:
undetectable
2v0mD-5tf4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM3
MINICHROMOSOME
MAINTENANCE PROTEIN
5


(Saccharomyces
cerevisiae)
PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB)
5 SER 5 624
THR 5 660
ARG 3 567
GLU 3 563
LEU 5 614
None
1.28A 2v0mD-5udb5:
undetectable
2v0mD-5udb5:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE


(Naegleria
fowleri)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A 132
ILE A 412
THR A  70
MET A 400
LEU A  67
None
None
None
ADN  A 502 (-3.8A)
None
1.38A 2v0mD-5v96A:
undetectable
2v0mD-5v96A:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens)
no annotation 7 ARG A 105
SER A 119
ILE A 301
ALA A 305
THR A 309
GLU A 374
LEU A 481
HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
RIT  A 602 ( 4.9A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 ( 4.8A)
None
0.65A 2v0mD-5veuA:
56.5
2v0mD-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens)
no annotation 7 ARG A 105
SER A 119
ILE A 301
PHE A 304
ALA A 305
THR A 309
LEU A 481
HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
RIT  A 602 ( 4.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
None
0.65A 2v0mD-5veuA:
56.5
2v0mD-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens)
no annotation 7 SER A 119
ILE A 301
PHE A 304
ALA A 305
THR A 309
ARG A 372
LEU A 481
RIT  A 602 (-3.7A)
RIT  A 602 ( 4.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
None
None
0.95A 2v0mD-5veuA:
56.5
2v0mD-5veuA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H


(Human
betaherpesvirus
5)
PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C)
5 ILE A 227
ALA A 341
THR A 337
GLU A 221
LEU A 333
None
1.39A 2v0mD-5vocA:
undetectable
2v0mD-5vocA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0s 60 KDA CHAPERONIN

(Escherichia
coli)
PF00118
(Cpn60_TCP1)
5 ARG A  58
ALA A  78
THR A  93
GLU A  59
LEU A  23
None
1.30A 2v0mD-5w0sA:
undetectable
2v0mD-5w0sA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
PF03739
(YjgP_YjgQ)
5 LEU F 350
ALA F 288
THR F 285
ARG F  97
LEU F  99
None
1.31A 2v0mD-5x5yF:
undetectable
2v0mD-5x5yF:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN


(Homo sapiens)
PF00415
(RCC1)
PF13540
(RCC1_2)
5 LEU A 159
ALA A  71
THR A 119
MET A 198
LEU A 142
None
1.25A 2v0mD-5xgsA:
undetectable
2v0mD-5xgsA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amz 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E


(Acinetobacter
baumannii)
PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2)
5 SER A 231
ILE A 252
ALA A 250
THR A 212
GLU A 179
None
None
None
MRD  A 301 (-3.1A)
None
1.32A 2v0mD-6amzA:
undetectable
2v0mD-6amzA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aoj CEG4

(Legionella
pneumophila)
no annotation 5 SER A  81
LEU A 196
PHE A  87
ARG A 184
LEU A 156
None
1.28A 2v0mD-6aojA:
undetectable
2v0mD-6aojA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN


(Influenza B
virus)
no annotation 5 SER A 464
LEU A 496
ALA A 500
THR A 518
LEU A 283
None
1.07A 2v0mD-6f5oA:
undetectable
2v0mD-6f5oA:
9.98