SIMILAR PATTERNS OF AMINO ACIDS FOR 2V0M_D_KLND1498
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bkh | MUCONATE LACTONIZINGENZYME (Pseudomonasputida) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | SER A 106LEU A 328ILE A 274ALA A 315LEU A 358 | None | 1.35A | 2v0mD-1bkhA:0.0 | 2v0mD-1bkhA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dxy | D-2-HYDROXYISOCAPROATE DEHYDROGENASE (Lactobacilluscasei) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | SER A 198LEU A 252ILE A 201THR A 113LEU A 117 | None | 1.38A | 2v0mD-1dxyA:0.0 | 2v0mD-1dxyA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hle | HORSE LEUKOCYTEELASTASE INHIBITOR (Equus caballus) |
PF00079(Serpin) | 5 | SER A 53LEU A 112ILE A 188PHE A 190ALA A 347 | None | 1.36A | 2v0mD-1hleA:0.0 | 2v0mD-1hleA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jmy | BILE-SALT-ACTIVATEDLIPASE (Homo sapiens) |
PF00135(COesterase) | 5 | LEU A 234ALA A 241ARG A 144GLU A 43LEU A 151 | None | 1.32A | 2v0mD-1jmyA:0.0 | 2v0mD-1jmyA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhz | METHANEMONOOXYGENASEHYDROXYLASE (Methylosinustrichosporium) |
PF02332(Phenol_Hydrox) | 5 | LEU D 204ILE D 193PHE D 192ALA D 189GLU D 460 | None | 1.27A | 2v0mD-1mhzD:1.4 | 2v0mD-1mhzD:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p1m | HYPOTHETICAL PROTEINTM0936 (Thermotogamaritima) |
PF01979(Amidohydro_1) | 5 | LEU A 62ALA A 58THR A 56ARG A 148GLU A 151 | NoneNoneNoneMET A5001 (-3.9A)None | 1.24A | 2v0mD-1p1mA:0.0 | 2v0mD-1p1mA:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sb8 | WBPP (Pseudomonasaeruginosa) |
PF01370(Epimerase) | 5 | ILE A 310ALA A 314ARG A 9GLU A 240LEU A 248 | None | 1.29A | 2v0mD-1sb8A:0.0 | 2v0mD-1sb8A:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1szs | 4-AMINOBUTYRATEAMINOTRANSFERASE (Escherichiacoli) |
PF00202(Aminotran_3) | 5 | SER A 217ILE A 205ALA A 238THR A 264ARG A 247 | None | 1.30A | 2v0mD-1szsA:0.0 | 2v0mD-1szsA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t6p | PHENYLALANINEAMMONIA-LYASE (Rhodotorulatoruloides) |
PF00221(Lyase_aromatic) | 5 | LEU A 386ALA A 510THR A 514ARG A 166LEU A 281 | None | 1.36A | 2v0mD-1t6pA:0.0 | 2v0mD-1t6pA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tvz | 3-HYDROXY-3-METHYLGLUTARYL-COA SYNTHASE (Staphylococcusaureus) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 5 | LEU A 285ILE A 118ALA A 114THR A 278MET A 54 | None | 1.39A | 2v0mD-1tvzA:undetectable | 2v0mD-1tvzA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uik | ALPHA PRIME SUBUNITOF BETA-CONGLYCININ (Glycine max) |
PF00190(Cupin_1) | 5 | ARG A 363LEU A 210PHE A 481ALA A 480LEU A 214 | None | 1.36A | 2v0mD-1uikA:undetectable | 2v0mD-1uikA:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wac | P2 PROTEIN (Pseudomonasvirus phi6) |
PF00680(RdRP_1) | 5 | LEU A 497ILE A 449ALA A 455THR A 323ARG A 507 | None | 1.25A | 2v0mD-1wacA:undetectable | 2v0mD-1wacA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wub | CONSERVEDHYPOTHETICAL PROTEINTT1927B (Thermusthermophilus) |
PF04264(YceI) | 5 | LEU A 101ILE A 50PHE A 82ALA A 48GLU A 166 | OTP A1001 ( 4.2A)NoneOTP A1001 (-4.1A)OTP A1001 (-3.6A)None | 1.21A | 2v0mD-1wubA:undetectable | 2v0mD-1wubA:15.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xsz | GUANINE NUCLEOTIDEEXCHANGE PROTEIN (Legionellapneumophila) |
PF01369(Sec7) | 5 | LEU A 53ILE A 27ARG A 109GLU A 66LEU A 62 | None | 1.16A | 2v0mD-1xszA:undetectable | 2v0mD-1xszA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y1u | SIGNAL TRANSDUCERAND ACTIVATOR OFTRANSCRIPTION 5A (Mus musculus) |
PF00017(SH2)PF01017(STAT_alpha)PF02864(STAT_bind) | 5 | LEU A 282ILE A 323ALA A 326THR A 329GLU A 454 | None | 1.12A | 2v0mD-1y1uA:undetectable | 2v0mD-1y1uA:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2abl | ABL TYROSINE KINASE (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1) | 5 | SER A 206ALA A 225THR A 231ARG A 171LEU A 184 | None | 1.38A | 2v0mD-2ablA:undetectable | 2v0mD-2ablA:13.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvm | TOXIN B (Clostridioidesdifficile) |
PF12918(TcdB_N)PF12919(TcdA_TcdB) | 5 | SER A 413ILE A 435PHE A 446THR A 464LEU A 468 | None | 1.28A | 2v0mD-2bvmA:undetectable | 2v0mD-2bvmA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d4a | MALATE DEHYDROGENASE (Aeropyrumpernix) |
no annotation | 5 | SER B 221ILE B 213ALA B 209THR B 206MET B 171 | None | 1.39A | 2v0mD-2d4aB:undetectable | 2v0mD-2d4aB:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dkp | PLECKSTRIN HOMOLOGYDOMAIN-CONTAININGFAMILY A MEMBER 5 (Homo sapiens) |
PF00169(PH) | 5 | LEU A 50ILE A 72ALA A 89THR A 96ARG A 83 | None | 1.29A | 2v0mD-2dkpA:undetectable | 2v0mD-2dkpA:12.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ery | RAS-RELATED PROTEINR-RAS2 (Homo sapiens) |
PF00071(Ras) | 5 | LEU A 17ILE A 123PHE A 168ALA A 167LEU A 30 | None | 1.29A | 2v0mD-2eryA:undetectable | 2v0mD-2eryA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f31 | DIAPHANOUS PROTEINHOMOLOG 1 (Mus musculus) |
PF06345(Drf_DAD)PF06367(Drf_FH3)PF06371(Drf_GBD) | 5 | ARG A 269LEU B 9ILE A 222MET A 274LEU A 254 | None | 1.14A | 2v0mD-2f31A:undetectable | 2v0mD-2f31A:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g2o | MALONYL COA-ACYLCARRIER PROTEINTRANSACYLASE (Escherichiacoli) |
PF00698(Acyl_transf_1) | 5 | SER A 97LEU A 44PHE A 33GLU A 274LEU A 19 | None | 1.26A | 2v0mD-2g2oA:undetectable | 2v0mD-2g2oA:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h5n | HYPOTHETICAL PROTEINPG_1108 (Porphyromonasgingivalis) |
PF05099(TerB) | 5 | ARG A 83LEU A 91ILE A 76ALA A 20THR A 19 | None | 1.34A | 2v0mD-2h5nA:undetectable | 2v0mD-2h5nA:15.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2htm | THIAZOLEBIOSYNTHESIS PROTEINTHIG (Thermusthermophilus) |
PF05690(ThiG) | 5 | ARG A 119ALA A 73THR A 70GLU A 118LEU A 97 | None | 1.33A | 2v0mD-2htmA:undetectable | 2v0mD-2htmA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iml | HYPOTHETICAL PROTEIN (Archaeoglobusfulgidus) |
PF04289(DUF447) | 5 | ILE A 15ALA A 17THR A 52ARG A 108LEU A 56 | NoneNoneFMN A 200 (-3.7A)NoneNone | 1.17A | 2v0mD-2imlA:undetectable | 2v0mD-2imlA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jok | PUTATIVEG-NUCLEOTIDEEXCHANGE FACTOR (Burkholderiapseudomallei) |
PF07487(SopE_GEF) | 5 | ARG A 129LEU A 119PHE A 229ARG A 142LEU A 149 | None | 1.34A | 2v0mD-2jokA:1.8 | 2v0mD-2jokA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2on5 | NA GLUTATHIONES-TRANSFERASE 2 (Necatoramericanus) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | SER A 72LEU A 194ILE A 21ALA A 25GLU A 84 | NoneNoneNoneEDO A 428 (-4.3A)None | 1.22A | 2v0mD-2on5A:undetectable | 2v0mD-2on5A:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pke | HALOACIDDELAHOGENASE-LIKEFAMILY HYDROLASE (Xanthomonascampestris) |
PF13419(HAD_2) | 5 | LEU A 56ILE A 98ALA A 82THR A 86LEU A 45 | None | 1.32A | 2v0mD-2pkeA:undetectable | 2v0mD-2pkeA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wbp | L-ARGININEBETA-HYDROXYLASE (Streptomycesvinaceus) |
PF02668(TauD) | 5 | ILE A 309PHE A 308ALA A 307ARG A 110LEU A 121 | None | 1.05A | 2v0mD-2wbpA:undetectable | 2v0mD-2wbpA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wbp | L-ARGININEBETA-HYDROXYLASE (Streptomycesvinaceus) |
PF02668(TauD) | 5 | LEU A 128PHE A 308ALA A 307ARG A 110LEU A 121 | None | 1.14A | 2v0mD-2wbpA:undetectable | 2v0mD-2wbpA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wu0 | PHYTASE (Klebsiellapneumoniae) |
PF00328(His_Phos_2) | 5 | LEU A 22ILE A 315ALA A 295THR A 299ARG A 366 | None | 1.23A | 2v0mD-2wu0A:undetectable | 2v0mD-2wu0A:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yev | CYTOCHROME C OXIDASEPOLYPEPTIDE I+IIICYTOCHROME C OXIDASESUBUNIT 2 (Thermusthermophilus) |
PF00034(Cytochrom_C)PF00115(COX1)PF00116(COX2)PF00510(COX3)PF02790(COX2_TM) | 5 | ILE B 183PHE B 31ALA B 170ARG A 447GLU B 199 | NoneNoneNoneHAS A1016 ( 3.1A) MG A1801 ( 2.6A) | 1.20A | 2v0mD-2yevB:undetectable | 2v0mD-2yevB:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yyb | HYPOTHETICAL PROTEINTTHA1606 (Thermusthermophilus) |
PF01784(NIF3) | 5 | ARG A 82LEU A 28ALA A 95GLU A 47LEU A 61 | None | 1.31A | 2v0mD-2yybA:undetectable | 2v0mD-2yybA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zfd | CALCINEURIN B-LIKEPROTEIN 2PUTATIVEUNCHARACTERIZEDPROTEIN T20L15_90 (Arabidopsisthaliana) |
PF03822(NAF)PF13499(EF-hand_7)PF13833(EF-hand_8) | 5 | ILE B 316ALA B 312THR A 171ARG A 189LEU A 191 | None | 1.31A | 2v0mD-2zfdB:undetectable | 2v0mD-2zfdB:13.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9p | CG5977-PA, ISOFORM A (Drosophilamelanogaster) |
PF00004(AAA)PF09336(Vps4_C) | 5 | LEU A 567ILE A 581ALA A 549THR A 553LEU A 602 | None | 1.11A | 2v0mD-3b9pA:undetectable | 2v0mD-3b9pA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c3v | ARACHIN ARAH3ISOFORM (Arachishypogaea) |
PF00190(Cupin_1) | 5 | SER A 178ILE A 92PHE A 150GLU A 54LEU A 75 | None | 1.30A | 2v0mD-3c3vA:undetectable | 2v0mD-3c3vA:18.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egl | DEGV FAMILY PROTEIN (Corynebacteriumglutamicum) |
PF02645(DegV) | 5 | LEU A 221ILE A 168PHE A 189ALA A 188GLU A 145 | NoneNoneNoneMLY A 187 ( 3.7A)None | 1.20A | 2v0mD-3eglA:undetectable | 2v0mD-3eglA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fj4 | MUCONATECYCLOISOMERASE (Pseudomonasprotegens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | SER A 108LEU A 330ILE A 276ALA A 317LEU A 360 | None | 1.36A | 2v0mD-3fj4A:undetectable | 2v0mD-3fj4A:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fj4 | MUCONATECYCLOISOMERASE (Pseudomonasprotegens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | SER A 112LEU A 330ILE A 276ALA A 317THR A 320 | None | 1.19A | 2v0mD-3fj4A:undetectable | 2v0mD-3fj4A:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fot | 15-O-ACETYLTRANSFERASE (Fusariumsporotrichioides) |
PF07428(Tri3) | 5 | LEU A 386ILE A 292PHE A 517ALA A 295THR A 298 | None | 1.15A | 2v0mD-3fotA:undetectable | 2v0mD-3fotA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h55 | ALPHA-N-ACETYLGALACTOSAMINIDASE (Homo sapiens) |
PF16499(Melibiase_2)PF17450(Melibiase_2_C) | 5 | PHE A 145ALA A 142ARG A 165GLU A 164LEU A 155 | NoneNoneNoneNAG A 624 ( 4.1A)None | 1.13A | 2v0mD-3h55A:undetectable | 2v0mD-3h55A:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hjv | MALONYL COA-ACYLCARRIER PROTEINTRANSACYLASE (Vibrio cholerae) |
PF00698(Acyl_transf_1) | 5 | SER A 102LEU A 49PHE A 38GLU A 279LEU A 24 | None | 1.23A | 2v0mD-3hjvA:undetectable | 2v0mD-3hjvA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ksc | LEGA CLASS (Pisum sativum) |
PF00190(Cupin_1) | 5 | SER A 142ILE A 70PHE A 114GLU A 32LEU A 53 | None | 1.18A | 2v0mD-3kscA:undetectable | 2v0mD-3kscA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mem | PUTATIVE SIGNALTRANSDUCTION PROTEIN (Marinobacterhydrocarbonoclasticus) |
PF04073(tRNA_edit)PF08668(HDOD) | 5 | ARG A 441LEU A 395ALA A 286GLU A 437LEU A 403 | None | 1.37A | 2v0mD-3memA:undetectable | 2v0mD-3memA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nfb | BETA-PEPTIDYLAMINOPEPTIDASE (Sphingosinicellaxenopeptidilytica) |
PF03576(Peptidase_S58) | 5 | ARG A 268LEU A 309ILE A 313ALA A 259THR A 257 | None | 1.25A | 2v0mD-3nfbA:undetectable | 2v0mD-3nfbA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ngo | CCR4-NOTTRANSCRIPTIONCOMPLEX SUBUNIT6-LIKE (Homo sapiens) |
PF03372(Exo_endo_phos) | 5 | SER A 237LEU A 332ILE A 285ALA A 329LEU A 405 | None | 1.07A | 2v0mD-3ngoA:undetectable | 2v0mD-3ngoA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o7q | L-FUCOSE-PROTONSYMPORTER (Escherichiacoli) |
PF07690(MFS_1) | 5 | LEU A 145ILE A 25PHE A 28ALA A 29LEU A 157 | None | 1.20A | 2v0mD-3o7qA:undetectable | 2v0mD-3o7qA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3opb | SWI5-DEPENDENT HOEXPRESSION PROTEIN 4 (Saccharomycescerevisiae) |
PF11701(UNC45-central) | 5 | LEU A 714PHE A 701ALA A 702GLU A 739LEU A 747 | None | 1.39A | 2v0mD-3opbA:undetectable | 2v0mD-3opbA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3opy | 6-PHOSPHOFRUCTO-1-KINASE BETA-SUBUNIT (Komagataellapastoris) |
PF00365(PFK) | 5 | SER B 347ALA B 481THR B 482GLU B 724LEU B 244 | None | 1.35A | 2v0mD-3opyB:undetectable | 2v0mD-3opyB:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pnz | PHOSPHOTRIESTERASEFAMILY PROTEIN (Listeriamonocytogenes) |
PF02126(PTE) | 5 | SER A 186LEU A 195ILE A 213ALA A 233ARG A 175 | None | 1.14A | 2v0mD-3pnzA:undetectable | 2v0mD-3pnzA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tgn | ADC OPERON REPRESSORADCR (Streptococcuspneumoniae) |
PF01047(MarR) | 5 | ILE A 72ALA A 71THR A 39GLU A 50LEU A 61 | None | 1.35A | 2v0mD-3tgnA:undetectable | 2v0mD-3tgnA:13.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b9p | TYPE 3ACELLULOSE-BINDINGDOMAIN PROTEIN (Ruminiclostridiumthermocellum) |
PF00942(CBM_3) | 5 | SER A 63LEU A 99ILE A 65ALA A 96THR A 93 | None | 1.38A | 2v0mD-4b9pA:undetectable | 2v0mD-4b9pA:17.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fbh | PROTEIN SYNTHESISINHIBITOR I (Hordeum vulgare) |
PF00161(RIP) | 5 | SER A 45PHE A 236ALA A 247ARG A 178LEU A 216 | NoneNoneNoneAMP A 301 (-3.0A)None | 1.29A | 2v0mD-4fbhA:undetectable | 2v0mD-4fbhA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 5 | LEU A1013ILE A1070ALA A 921GLU A 993LEU A 937 | None | 1.29A | 2v0mD-4g34A:undetectable | 2v0mD-4g34A:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gl0 | LMO0810 PROTEIN (Listeriamonocytogenes) |
PF13416(SBP_bac_8) | 5 | ILE A 170ALA A 233THR A 235ARG A 177LEU A 141 | None | 1.37A | 2v0mD-4gl0A:undetectable | 2v0mD-4gl0A:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k51 | EUKARYOTICTRANSLATIONINITIATION FACTOR 3SUBUNIT A (Saccharomycescerevisiae) |
PF01399(PCI) | 5 | SER A 369ILE A 370ALA A 332THR A 335LEU A 297 | None | 1.23A | 2v0mD-4k51A:undetectable | 2v0mD-4k51A:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l22 | PHOSPHORYLASE (Streptococcusmutans) |
PF00343(Phosphorylase) | 5 | SER A 490LEU A 478ILE A 492ALA A 587LEU A 472 | None | 1.32A | 2v0mD-4l22A:undetectable | 2v0mD-4l22A:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mou | ENOYL-COAHYDRATASE/ISOMERASEFAMILY PROTEIN (Paenarthrobacteraurescens) |
PF00378(ECH_1) | 5 | ILE A 132PHE A 131ALA A 190GLU A 199LEU A 205 | None | 1.31A | 2v0mD-4mouA:undetectable | 2v0mD-4mouA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nnb | OBCA, OXALATEBIOSYNTHETICCOMPONENT A (Burkholderiaglumae) |
PF05853(BKACE) | 5 | LEU A 455ILE A 397ALA A 377GLU A 433LEU A 465 | None | 1.25A | 2v0mD-4nnbA:undetectable | 2v0mD-4nnbA:22.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ny4 | CYTOCHROME P450 3A4 (Homo sapiens) |
PF00067(p450) | 7 | ARG A 105SER A 119ILE A 301ALA A 305THR A 309MET A 371ARG A 372 | HEM A 601 ( 2.8A)2QH A 602 (-3.9A)None2QH A 602 ( 3.6A)2QH A 602 ( 3.7A)NoneNone | 0.59A | 2v0mD-4ny4A:53.0 | 2v0mD-4ny4A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ny4 | CYTOCHROME P450 3A4 (Homo sapiens) |
PF00067(p450) | 5 | ARG A 105SER A 119ILE A 301PHE A 304ALA A 305 | HEM A 601 ( 2.8A)2QH A 602 (-3.9A)None2QH A 602 (-3.3A)2QH A 602 ( 3.6A) | 1.06A | 2v0mD-4ny4A:53.0 | 2v0mD-4ny4A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ny4 | CYTOCHROME P450 3A4 (Homo sapiens) |
PF00067(p450) | 7 | ARG A 105SER A 119LEU A 210ILE A 301ALA A 305THR A 309MET A 371 | HEM A 601 ( 2.8A)2QH A 602 (-3.9A)NoneNone2QH A 602 ( 3.6A)2QH A 602 ( 3.7A)None | 1.03A | 2v0mD-4ny4A:53.0 | 2v0mD-4ny4A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ny4 | CYTOCHROME P450 3A4 (Homo sapiens) |
PF00067(p450) | 5 | ILE A 301ALA A 305THR A 309MET A 371GLU A 374 | None2QH A 602 ( 3.6A)2QH A 602 ( 3.7A)None2QH A 602 ( 4.8A) | 0.81A | 2v0mD-4ny4A:53.0 | 2v0mD-4ny4A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o8a | BIFUNCTIONAL PROTEINPUTA (Escherichiacoli) |
PF01619(Pro_dh)PF14850(Pro_dh-DNA_bdg) | 5 | ILE A 265ALA A 268THR A 261ARG A 253GLU A 547 | None | 1.36A | 2v0mD-4o8aA:undetectable | 2v0mD-4o8aA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p1t | ERYTHROCYTE MEMBRANEPROTEIN 1 (Plasmodiumfalciparum) |
PF03011(PFEMP)PF05424(Duffy_binding) | 5 | LEU A1310ILE A1227ALA A1303GLU A1367LEU A1272 | None | 1.35A | 2v0mD-4p1tA:undetectable | 2v0mD-4p1tA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pwu | MODULATOR PROTEINMZRA (Klebsiellapneumoniae) |
PF13721(SecD-TM1) | 5 | LEU A 94ILE A 65ALA A 89GLU A 36LEU A 106 | None | 0.95A | 2v0mD-4pwuA:undetectable | 2v0mD-4pwuA:11.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u1d | EUKARYOTICTRANSLATIONINITIATION FACTOR 3SUBUNIT A (Saccharomycescerevisiae) |
no annotation | 5 | SER C 369ILE C 370ALA C 332THR C 335LEU C 297 | None | 1.22A | 2v0mD-4u1dC:undetectable | 2v0mD-4u1dC:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uer | EIF3A (Lachanceakluyveri) |
no annotation | 5 | SER a 369ILE a 370ALA a 332THR a 335LEU a 297 | None | 1.18A | 2v0mD-4uera:undetectable | 2v0mD-4uera:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uph | SULFATASE (SULFURICESTER HYDROLASE)PROTEIN (Agrobacteriumtumefaciens) |
PF00884(Sulfatase)PF16347(DUF4976) | 5 | LEU A 197PHE A 218ALA A 23ARG A 356LEU A 305 | None | 1.02A | 2v0mD-4uphA:undetectable | 2v0mD-4uphA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wd3 | L-AMINO ACID LIGASE (Bacillussubtilis) |
PF13535(ATP-grasp_4) | 5 | ARG A 92LEU A 64ILE A 7THR A 56LEU A 58 | None | 1.36A | 2v0mD-4wd3A:undetectable | 2v0mD-4wd3A:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xz7 | PUTATIVEUNCHARACTERIZEDPROTEIN (Streptococcussuis) |
PF01841(Transglut_core) | 5 | SER A 243LEU A 318PHE A 313ALA A 312THR A 308 | None | 1.37A | 2v0mD-4xz7A:undetectable | 2v0mD-4xz7A:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ydj | HEAVY CHAIN OFANTIBODY 44-VRC13.01LIGHT CHAIN OFANTIBODY 44-VRC13.01 (Homo sapiens) |
no annotation | 5 | ILE H 35ALA H 93ARG L 53GLU H 100LEU L 46 | None | 1.36A | 2v0mD-4ydjH:undetectable | 2v0mD-4ydjH:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yyc | PUTATIVETRIMETHYLAMINEMETHYLTRANSFERASE (Sinorhizobiummeliloti) |
PF06253(MTTB) | 5 | LEU A 337ALA A 286THR A 290GLU A 55LEU A 345 | None | 1.15A | 2v0mD-4yycA:undetectable | 2v0mD-4yycA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zk3 | SERPIN B3 (Homo sapiens) |
PF00079(Serpin) | 5 | SER A 30LEU A 101ILE A 180PHE A 182ALA A 343 | None | 1.38A | 2v0mD-4zk3A:undetectable | 2v0mD-4zk3A:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zuz | SIDC (Legionellapneumophila) |
no annotation | 5 | ARG A 797LEU A 780PHE A 777ALA A 773GLU A 795 | None | 1.31A | 2v0mD-4zuzA:undetectable | 2v0mD-4zuzA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwp | DESIGNED HELICALREPEAT PROTEIN (syntheticconstruct) |
no annotation | 5 | ARG A 211LEU A 135THR A 141GLU A 212LEU A 191 | None | 1.22A | 2v0mD-5cwpA:undetectable | 2v0mD-5cwpA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f56 | SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE (Deinococcusradiodurans) |
PF01368(DHH)PF02272(DHHA1) | 5 | ALA A 216THR A 220ARG A 184GLU A 50LEU A 187 | None | 1.30A | 2v0mD-5f56A:undetectable | 2v0mD-5f56A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gqq | HEME-BINDING PROTEIN2 (Homo sapiens) |
PF04832(SOUL) | 5 | LEU A 69ILE A 62PHE A 66GLU A 191LEU A 185 | None | 1.12A | 2v0mD-5gqqA:undetectable | 2v0mD-5gqqA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hs0 | ANKYRIN DOMAINPROTEIN ANK1C4_7 (syntheticconstruct) |
PF12796(Ank_2) | 5 | LEU A 23ILE A 16ALA A 17GLU A 46LEU A 56 | None | 1.17A | 2v0mD-5hs0A:undetectable | 2v0mD-5hs0A:16.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5idj | CELL CYCLE HISTIDINEKINASE CCKA (Caulobactervibrioides) |
PF00512(HisKA)PF02518(HATPase_c) | 5 | LEU A 388ILE A 475THR A 408ARG A 436LEU A 396 | None | 1.36A | 2v0mD-5idjA:undetectable | 2v0mD-5idjA:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jbh | 30S RIBOSOMALPROTEIN US7 (Pyrococcusabyssi) |
PF00177(Ribosomal_S7) | 5 | ILE H 111PHE H 108ALA H 107ARG H 163LEU H 67 | NoneNoneNone U 21336 ( 4.4A)None | 1.19A | 2v0mD-5jbhH:undetectable | 2v0mD-5jbhH:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jqp | GLUCOSIDASE 2SUBUNIT BETA-LIKEPROTEIN (Chaetomiumthermophilum) |
PF12999(PRKCSH-like) | 5 | SER B 49LEU B 88ILE B 50THR B 101LEU B 92 | None | 1.34A | 2v0mD-5jqpB:undetectable | 2v0mD-5jqpB:14.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jr9 | NEQ131 (Nanoarchaeumequitans) |
PF01997(Translin) | 5 | LEU B 148ILE B 172MET B 40GLU B 129LEU B 89 | None | 1.35A | 2v0mD-5jr9B:undetectable | 2v0mD-5jr9B:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lfd | ALLANTOIN RACEMASE (Pseudomonasfluorescens) |
no annotation | 5 | ILE A 18ALA A 184MET A 144GLU A 45LEU A 149 | None | 1.26A | 2v0mD-5lfdA:undetectable | 2v0mD-5lfdA:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mpd | 26S PROTEASOMEREGULATORY SUBUNITRPN7 (Saccharomycescerevisiae) |
PF01399(PCI)PF10602(RPN7) | 5 | SER R 254ILE R 289ALA R 285THR R 283GLU R 275 | None | 1.26A | 2v0mD-5mpdR:undetectable | 2v0mD-5mpdR:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mpm | SARCOPLASMIC/ENDOPLASMIC RETICULUMCALCIUM ATPASE 2 (Sus scrofa) |
no annotation | 5 | LEU A 356ILE A 348ARG A 334GLU A 731LEU A 734 | NoneNoneNone K A1005 (-2.9A)None | 1.25A | 2v0mD-5mpmA:2.4 | 2v0mD-5mpmA:10.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t8v | PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
PF12765(Cohesin_HEAT)PF12830(Nipped-B_C) | 5 | SER A1333LEU A1313ILE A1363ALA A1367LEU A1373 | None | 1.22A | 2v0mD-5t8vA:undetectable | 2v0mD-5t8vA:16.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tf4 | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE[NADH] (Bartonellahenselae) |
PF13561(adh_short_C2) | 5 | SER A 123LEU A 104ALA A 199THR A 197GLU A 170 | NoneNoneNAD A 300 (-3.2A)NAD A 300 (-2.8A)None | 1.24A | 2v0mD-5tf4A:undetectable | 2v0mD-5tf4A:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5udb | DNA REPLICATIONLICENSING FACTORMCM3MINICHROMOSOMEMAINTENANCE PROTEIN5 (Saccharomycescerevisiae) |
PF00493(MCM)PF14551(MCM_N)PF17207(MCM_OB) | 5 | SER 5 624THR 5 660ARG 3 567GLU 3 563LEU 5 614 | None | 1.28A | 2v0mD-5udb5:undetectable | 2v0mD-5udb5:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v96 | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE (Naegleriafowleri) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LEU A 132ILE A 412THR A 70MET A 400LEU A 67 | NoneNoneNoneADN A 502 (-3.8A)None | 1.38A | 2v0mD-5v96A:undetectable | 2v0mD-5v96A:21.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5veu | CYTOCHROME P450 3A5 (Homo sapiens) |
no annotation | 7 | ARG A 105SER A 119ILE A 301ALA A 305THR A 309GLU A 374LEU A 481 | HEM A 601 (-2.8A)RIT A 602 (-3.7A)RIT A 602 ( 4.9A)HEM A 601 (-3.4A)HEM A 601 ( 3.5A)RIT A 602 ( 4.8A)None | 0.65A | 2v0mD-5veuA:56.5 | 2v0mD-5veuA:83.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5veu | CYTOCHROME P450 3A5 (Homo sapiens) |
no annotation | 7 | ARG A 105SER A 119ILE A 301PHE A 304ALA A 305THR A 309LEU A 481 | HEM A 601 (-2.8A)RIT A 602 (-3.7A)RIT A 602 ( 4.9A)RIT A 602 (-3.7A)HEM A 601 (-3.4A)HEM A 601 ( 3.5A)None | 0.65A | 2v0mD-5veuA:56.5 | 2v0mD-5veuA:83.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5veu | CYTOCHROME P450 3A5 (Homo sapiens) |
no annotation | 7 | SER A 119ILE A 301PHE A 304ALA A 305THR A 309ARG A 372LEU A 481 | RIT A 602 (-3.7A)RIT A 602 ( 4.9A)RIT A 602 (-3.7A)HEM A 601 (-3.4A)HEM A 601 ( 3.5A)NoneNone | 0.95A | 2v0mD-5veuA:56.5 | 2v0mD-5veuA:83.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5voc | ENVELOPEGLYCOPROTEIN H (Humanbetaherpesvirus5) |
PF02489(Herpes_glycop_H)PF17488(Herpes_glycoH_C) | 5 | ILE A 227ALA A 341THR A 337GLU A 221LEU A 333 | None | 1.39A | 2v0mD-5vocA:undetectable | 2v0mD-5vocA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w0s | 60 KDA CHAPERONIN (Escherichiacoli) |
PF00118(Cpn60_TCP1) | 5 | ARG A 58ALA A 78THR A 93GLU A 59LEU A 23 | None | 1.30A | 2v0mD-5w0sA:undetectable | 2v0mD-5w0sA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x5y | UNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF03739(YjgP_YjgQ) | 5 | LEU F 350ALA F 288THR F 285ARG F 97LEU F 99 | None | 1.31A | 2v0mD-5x5yF:undetectable | 2v0mD-5x5yF:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgs | RCC1-LIKE GEXCHANGINGFACTOR-LIKE PROTEIN (Homo sapiens) |
PF00415(RCC1)PF13540(RCC1_2) | 5 | LEU A 159ALA A 71THR A 119MET A 198LEU A 142 | None | 1.25A | 2v0mD-5xgsA:undetectable | 2v0mD-5xgsA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6amz | 2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATEN-SUCCINYLTRANSFERASE (Acinetobacterbaumannii) |
PF00132(Hexapep)PF14602(Hexapep_2)PF14805(THDPS_N_2) | 5 | SER A 231ILE A 252ALA A 250THR A 212GLU A 179 | NoneNoneNoneMRD A 301 (-3.1A)None | 1.32A | 2v0mD-6amzA:undetectable | 2v0mD-6amzA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6aoj | CEG4 (Legionellapneumophila) |
no annotation | 5 | SER A 81LEU A 196PHE A 87ARG A 184LEU A 156 | None | 1.28A | 2v0mD-6aojA:undetectable | 2v0mD-6aojA:10.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f5o | POLYMERASE ACIDICPROTEIN (Influenza Bvirus) |
no annotation | 5 | SER A 464LEU A 496ALA A 500THR A 518LEU A 283 | None | 1.07A | 2v0mD-6f5oA:undetectable | 2v0mD-6f5oA:9.98 |