SIMILAR PATTERNS OF AMINO ACIDS FOR 2V0M_C_KLNC1498

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fez PHOSPHONOACETALDEHYD
E HYDROLASE

(Bacillus cereus) 		PF13419
(HAD_2) 		5 PHE A 237
LEU A 252
ILE A 122
ALA A   8
MET A 191
 None
 1.22A 2v0mC-1fezA:
undetectable		 2v0mC-1fezA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he9 EXOENZYME S

(Pseudomonas
aeruginosa) 		PF03545
(YopE) 		5 LEU A 171
LEU A 181
ALA A 151
THR A 150
GLU A 122
 None
 1.27A 2v0mC-1he9A:
undetectable		 2v0mC-1he9A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		5 ARG A 486
LEU A 501
LEU A 500
ALA A 468
THR A 471
 None
 1.05A 2v0mC-1jqoA:
0.0		 2v0mC-1jqoA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
gordonii) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 PHE A 129
LEU A   5
ALA A  39
MET A 144
GLU A 139
 None
 1.28A 2v0mC-1k20A:
0.0		 2v0mC-1k20A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 LEU A 250
LEU A 251
ILE A 109
ALA A 216
THR A  93
 None
None
None
None
PO4  A 301 (-3.8A)
 1.08A 2v0mC-1k27A:
0.0		 2v0mC-1k27A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpp PEPSIN

(Rhizomucor
pusillus) 		PF00026
(Asp) 		5 PHE A 284
LEU A 262
LEU A 260
PHE A 322
ALA A 211
 None
 1.23A 2v0mC-1mppA:
0.0		 2v0mC-1mppA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n97 CYP175A1

(Thermus
thermophilus) 		PF00067
(p450) 		5 LEU A 236
LEU A 237
PHE A 310
ALA A 229
ARG A 355
 None
None
None
HEM  A 602 ( 4.2A)
None
 1.09A 2v0mC-1n97A:
33.4		 2v0mC-1n97A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 175
LEU A 177
PHE A 397
ILE A 424
ALA A 168
 None
 1.21A 2v0mC-1tkcA:
0.0		 2v0mC-1tkcA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		5 LEU A 497
ILE A 449
ALA A 455
THR A 323
ARG A 507
 None
 1.25A 2v0mC-1wacA:
0.0		 2v0mC-1wacA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C2

(Methylococcus
capsulatus) 		PF04896
(AmoC) 		5 PHE C  92
ILE C 145
ALA C 149
THR C 153
GLU C 100
 None
 1.24A 2v0mC-1yewC:
undetectable		 2v0mC-1yewC:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1

(Bacteroides
thetaiotaomicron) 		no annotation 5 ARG A 183
LEU A 152
PHE A 169
ALA A 195
ARG A 186
 None
 1.25A 2v0mC-1zxoA:
0.0		 2v0mC-1zxoA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		PF12937
(F-box-like) 		5 SER B2320
LEU B2340
LEU B2315
PHE B2331
THR B2394
 None
 1.21A 2v0mC-2assB:
undetectable		 2v0mC-2assB:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkw HYPOTHETICAL PROTEIN
KIAA1240

(Homo sapiens) 		PF00439
(Bromodomain) 		5 ARG A  29
LEU A  69
PHE A  68
ILE A 107
ALA A 106
 None
 1.11A 2v0mC-2dkwA:
undetectable		 2v0mC-2dkwA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eaa 7S GLOBULIN-3

(Vigna angularis) 		PF00190
(Cupin_1) 		5 LEU A 278
LEU A 277
ILE A 299
ALA A 297
THR A 345
 None
 1.08A 2v0mC-2eaaA:
undetectable		 2v0mC-2eaaA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		5 PHE A 299
LEU A 538
LEU A 535
ALA A 469
GLU A 459
 None
 1.26A 2v0mC-2f5uA:
undetectable		 2v0mC-2f5uA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr2 HYPOTHETICAL PROTEIN
RV2717C

(Mycobacterium
tuberculosis) 		PF08768
(DUF1794) 		5 LEU A  49
LEU A  71
PHE A  41
ALA A  11
GLU A 107
 None
 1.25A 2v0mC-2fr2A:
undetectable		 2v0mC-2fr2A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 LEU A 371
LEU A 381
ALA A 366
THR A 391
MET A 361
 None
None
LLP  A 396 ( 3.5A)
None
None
 1.26A 2v0mC-2okkA:
undetectable		 2v0mC-2okkA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owo DNA LIGASE

(Escherichia
coli) 		PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 LEU A 538
LEU A 535
PHE A 564
ALA A 509
THR A 507
 None
None
None
None
SO4  A 674 ( 4.1A)
 1.12A 2v0mC-2owoA:
undetectable		 2v0mC-2owoA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pas PARVALBUMIN

(Esox lucius) 		PF13499
(EF-hand_7) 		5 PHE A  70
LEU A  86
LEU A  63
ALA A  80
THR A  78
 None
 1.22A 2v0mC-2pasA:
undetectable		 2v0mC-2pasA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 121
ILE A 310
ALA A 314
THR A 317
ARG A 283
 None
 1.05A 2v0mC-2pceA:
undetectable		 2v0mC-2pceA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 PHE A 133
LEU A 247
LEU A 246
ILE A 308
ALA A 221
 None
 1.23A 2v0mC-2q1yA:
undetectable		 2v0mC-2q1yA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk2 LP04448P

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		5 PHE A 370
LEU A 347
LEU A 344
PHE A 355
ALA A 323
 None
 1.22A 2v0mC-2qk2A:
undetectable		 2v0mC-2qk2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3b YJEF-RELATED PROTEIN

(Enterococcus
faecalis) 		PF01256
(Carb_kinase) 		5 SER A  51
LEU A  97
LEU A  30
ALA A 227
GLU A  74
 None
 1.22A 2v0mC-2r3bA:
undetectable		 2v0mC-2r3bA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vtx NPM-A PROTEIN

(Xenopus laevis) 		PF03066
(Nucleoplasmin) 		5 LEU A 111
LEU A  23
ILE A  62
ALA A 106
GLU A  73
 None
 1.23A 2v0mC-2vtxA:
undetectable		 2v0mC-2vtxA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 LEU M 487
ILE M 480
ALA M 465
ARG M 251
GLU M 266
 None
 1.20A 2v0mC-2w4gM:
undetectable		 2v0mC-2w4gM:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae) 		PF00328
(His_Phos_2) 		5 LEU A  22
ILE A 315
ALA A 295
THR A 299
ARG A 366
 None
 1.25A 2v0mC-2wu0A:
undetectable		 2v0mC-2wu0A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 543
PHE A 547
ILE A  85
ALA A  88
THR A  90
 None
 1.23A 2v0mC-2x40A:
undetectable		 2v0mC-2x40A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		5 SER A 634
LEU A 582
LEU A 578
ILE A 635
ALA A 380
 None
 1.18A 2v0mC-3aqpA:
undetectable		 2v0mC-3aqpA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9p CG5977-PA, ISOFORM A

(Drosophila
melanogaster) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 LEU A 567
PHE A 568
ILE A 581
ALA A 549
THR A 553
 None
 0.88A 2v0mC-3b9pA:
undetectable		 2v0mC-3b9pA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chm COP9 SIGNALOSOME
COMPLEX SUBUNIT 7

(Arabidopsis
thaliana) 		PF01399
(PCI) 		5 LEU A  68
LEU A  65
PHE A  69
ALA A  81
THR A  82
 None
 1.22A 2v0mC-3chmA:
undetectable		 2v0mC-3chmA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czp PUTATIVE
POLYPHOSPHATE KINASE
2

(Pseudomonas
aeruginosa) 		PF03976
(PPK2) 		5 LEU A 370
ILE A 390
ALA A 386
ARG A 340
GLU A 339
 None
 1.25A 2v0mC-3czpA:
undetectable		 2v0mC-3czpA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8b FIDGETIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 LEU A 485
PHE A 486
ILE A 499
ALA A 467
THR A 471
 None
 1.28A 2v0mC-3d8bA:
undetectable		 2v0mC-3d8bA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans) 		PF00432
(Prenyltrans) 		5 LEU B 354
LEU B 357
PHE B 337
ILE B   6
ALA B 366
 None
 1.21A 2v0mC-3draB:
undetectable		 2v0mC-3draB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f95 BETA-GLUCOSIDASE

(Pseudoalteromonas
sp. BB1) 		no annotation 5 PHE A 750
ARG A 783
LEU A 798
LEU A 716
ILE A 778
 None
 1.16A 2v0mC-3f95A:
undetectable		 2v0mC-3f95A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE

(Pseudomonas
protegens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 SER A 112
LEU A 330
ILE A 276
ALA A 317
THR A 320
 None
 1.23A 2v0mC-3fj4A:
undetectable		 2v0mC-3fj4A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Aquifex
aeolicus) 		PF01706
(FliG_C)
PF14841
(FliG_M)
PF14842
(FliG_N) 		5 LEU A  64
LEU A  63
PHE A  80
ILE A  72
ALA A  70
 None
 1.15A 2v0mC-3hjlA:
undetectable		 2v0mC-3hjlA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k33 DEATH ON CURING
PROTEIN

(Escherichia
virus P1) 		PF02661
(Fic) 		5 PHE A  68
ILE A  35
ALA A  61
THR A  57
ARG A   2
 None
 1.27A 2v0mC-3k33A:
undetectable		 2v0mC-3k33A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Coxiella
burnetii) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 PHE A  88
SER A 139
LEU A  80
ALA A  19
THR A  18
 None
 1.26A 2v0mC-3k96A:
1.1		 2v0mC-3k96A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4e UNCHARACTERIZED
PEPTIDASE LMO0363

(Listeria
monocytogenes) 		PF03575
(Peptidase_S51) 		5 LEU A  92
ILE A 105
ALA A 101
THR A  99
GLU A  61
 None
 1.16A 2v0mC-3l4eA:
undetectable		 2v0mC-3l4eA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lb9 ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		5 SER A   9
LEU A  39
ILE A 172
ALA A  31
ARG A 114
 None
 1.28A 2v0mC-3lb9A:
undetectable		 2v0mC-3lb9A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE

(Coccidioides
immitis) 		PF13409
(GST_N_2)
PF14497
(GST_C_3) 		5 LEU A  82
LEU A  85
ILE A 119
ALA A 177
THR A 175
 None
 1.27A 2v0mC-3lg6A:
undetectable		 2v0mC-3lg6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljl TRANSCRIPTIONAL
REGULATOR LUXT

(Vibrio
parahaemolyticus) 		PF00440
(TetR_N) 		5 PHE A  83
LEU A 100
ILE A 107
ALA A 117
MET A 127
 None
 1.25A 2v0mC-3ljlA:
undetectable		 2v0mC-3ljlA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n28 PHOSPHOSERINE
PHOSPHATASE

(Vibrio cholerae) 		PF00702
(Hydrolase) 		5 LEU A  88
ILE A  38
ALA A  96
THR A 298
GLU A 182
 None
 1.26A 2v0mC-3n28A:
undetectable		 2v0mC-3n28A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfb BETA-PEPTIDYL
AMINOPEPTIDASE

(Sphingosinicella
xenopeptidilytica) 		PF03576
(Peptidase_S58) 		5 ARG A 268
LEU A 309
ILE A 313
ALA A 259
THR A 257
 None
 1.26A 2v0mC-3nfbA:
undetectable		 2v0mC-3nfbA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 SER A 237
LEU A 332
LEU A 354
ILE A 285
ALA A 329
 None
 1.07A 2v0mC-3ngoA:
undetectable		 2v0mC-3ngoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnz PHOSPHOTRIESTERASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF02126
(PTE) 		5 SER A 186
LEU A 195
ILE A 213
ALA A 233
ARG A 175
 None
 1.10A 2v0mC-3pnzA:
undetectable		 2v0mC-3pnzA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Bacteroides
thetaiotaomicron) 		PF13306
(LRR_5) 		5 LEU A 336
LEU A 345
PHE A 313
ALA A 307
THR A 330
 None
 1.28A 2v0mC-3sb4A:
undetectable		 2v0mC-3sb4A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl8 EFFECTOR PROTEIN
HOPAB2

(Pseudomonas
syringae group
genomosp. 3) 		PF16847
(AvrPtoB_bdg) 		5 LEU B 341
LEU B 344
ILE B 317
ALA B 302
THR B 301
 None
 1.25A 2v0mC-3tl8B:
undetectable		 2v0mC-3tl8B:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 ARG A  55
LEU A 326
ALA A 340
THR A 338
GLU A 378
 None
 1.26A 2v0mC-3u0kA:
undetectable		 2v0mC-3u0kA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9w LEUKOTRIENE A-4
HYDROLASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 LEU A1404
LEU A1407
ILE A1328
ALA A1244
GLU A1318
 None
None
None
None
ZN  A2001 ( 2.2A)
 1.28A 2v0mC-3u9wA:
undetectable		 2v0mC-3u9wA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 PHE A 275
LEU A 214
LEU A 236
ILE A 200
THR A 228
 None
 1.01A 2v0mC-3zynA:
undetectable		 2v0mC-3zynA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg0 COMPLEMENT
REGULATOR-ACQUIRING
SURFACE PROTEIN 2
(CRASP-2 (CRASP-2)

(Borreliella
burgdorferi) 		no annotation 5 PHE A  18
LEU A 165
LEU A 168
ILE A  32
ALA A  31
 None
 1.01A 2v0mC-4bg0A:
undetectable		 2v0mC-4bg0A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		5 PHE A 284
LEU A 394
LEU A 250
PHE A 398
THR A 297
 None
 1.19A 2v0mC-4d4lA:
undetectable		 2v0mC-4d4lA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 ARG A  50
LEU A 248
LEU A 252
PHE A 221
ARG A  48
 None
 1.25A 2v0mC-4efcA:
undetectable		 2v0mC-4efcA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es6 UROPORPHYRINOGEN-III
SYNTHASE

(Pseudomonas
aeruginosa) 		PF02602
(HEM4) 		5 ARG A 150
LEU A 116
LEU A 117
PHE A 122
ILE A 135
 None
 0.84A 2v0mC-4es6A:
undetectable		 2v0mC-4es6A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glx DNA LIGASE

(Escherichia
coli) 		PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 LEU A 538
LEU A 535
PHE A 564
ALA A 509
THR A 507
 None
None
None
None
SO4  A 602 ( 3.9A)
 1.13A 2v0mC-4glxA:
undetectable		 2v0mC-4glxA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 PHE A 759
LEU A 850
PHE A 824
ILE A 833
ALA A 828
 None
 1.25A 2v0mC-4gzuA:
undetectable		 2v0mC-4gzuA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h18 CMT1

(Corynebacterium
glutamicum) 		PF00756
(Esterase) 		5 PHE A 142
SER A 195
LEU A 275
ALA A 216
THR A 218
 None
 1.25A 2v0mC-4h18A:
undetectable		 2v0mC-4h18A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvn HYPOTHETICAL PROTEIN

(Catenulispora
acidiphila) 		PF12680
(SnoaL_2) 		5 LEU A  25
LEU A  22
PHE A  26
ALA A  11
THR A  15
 None
 1.28A 2v0mC-4hvnA:
undetectable		 2v0mC-4hvnA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i98 SEGREGATION AND
CONDENSATION PROTEIN
B

(Streptococcus
pneumoniae) 		PF04079
(SMC_ScpB) 		5 LEU B  39
LEU B  56
ILE B  19
ALA B  62
THR B  59
 None
 1.18A 2v0mC-4i98B:
undetectable		 2v0mC-4i98B:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij4 CHITINASE A

(Gemmabryum
coronatum) 		PF00182
(Glyco_hydro_19) 		5 SER A  62
LEU A  28
PHE A  12
ILE A  58
THR A 135
 None
 1.02A 2v0mC-4ij4A:
undetectable		 2v0mC-4ij4A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij4 CHITINASE A

(Gemmabryum
coronatum) 		PF00182
(Glyco_hydro_19) 		5 SER A  62
PHE A  12
ILE A  58
ALA A 136
THR A 135
 None
 1.03A 2v0mC-4ij4A:
undetectable		 2v0mC-4ij4A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		5 LEU A 442
LEU A 339
PHE A 328
ALA A 321
THR A 319
 None
 1.21A 2v0mC-4j9uA:
undetectable		 2v0mC-4j9uA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		5 ARG A 144
LEU A 185
LEU A 164
PHE A 158
ALA A 190
 None
 1.19A 2v0mC-4kngA:
undetectable		 2v0mC-4kngA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l15 FIDGETIN-LIKE
PROTEIN 1

(Caenorhabditis
elegans) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 LEU A 400
PHE A 401
ILE A 414
ALA A 382
THR A 386
 None
 1.15A 2v0mC-4l15A:
undetectable		 2v0mC-4l15A:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		6 ARG A 105
SER A 119
LEU A 210
ILE A 301
ALA A 305
THR A 309
 HEM  A 601 ( 2.8A)
2QH  A 602 (-3.9A)
None
None
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
 1.01A 2v0mC-4ny4A:
51.9		 2v0mC-4ny4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		9 PHE A  57
ARG A 105
SER A 119
PHE A 241
ILE A 301
ALA A 305
THR A 309
MET A 371
ARG A 372
 None
HEM  A 601 ( 2.8A)
2QH  A 602 (-3.9A)
2QH  A 602 (-4.5A)
None
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
None
None
 0.82A 2v0mC-4ny4A:
51.9		 2v0mC-4ny4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		6 PHE A  57
PHE A 241
ALA A 305
THR A 309
MET A 371
GLU A 374
 None
2QH  A 602 (-4.5A)
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
None
2QH  A 602 ( 4.8A)
 1.18A 2v0mC-4ny4A:
51.9		 2v0mC-4ny4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol8 REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Saccharomyces
cerevisiae) 		PF00078
(RVT_1) 		5 LEU A 187
ILE A  55
ALA A 123
THR A 119
GLU A 179
 None
 1.28A 2v0mC-4ol8A:
undetectable		 2v0mC-4ol8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p13 MEDIUM-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  87
PHE A  30
ILE A  53
ALA A  97
GLU A  41
 None
 1.22A 2v0mC-4p13A:
undetectable		 2v0mC-4p13A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qd9 THIOESTERASE PA1618

(Pseudomonas
aeruginosa) 		PF03061
(4HBT) 		5 SER A  65
LEU A 120
ILE A  27
ALA A  39
ARG A 132
 None
 1.19A 2v0mC-4qd9A:
undetectable		 2v0mC-4qd9A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 LEU A4180
LEU A4183
PHE A4179
ILE A4217
ALA A4202
 None
 1.02A 2v0mC-4rh7A:
undetectable		 2v0mC-4rh7A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ulx LPBCA-L89K
THIOREDOXIN

(synthetic
construct) 		PF00085
(Thioredoxin) 		5 PHE A  11
LEU A  44
LEU A  23
ILE A  37
ALA A  38
 None
None
None
None
CL  A1107 (-3.6A)
 1.27A 2v0mC-4ulxA:
undetectable		 2v0mC-4ulxA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpz CYTOCHROME P450

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 LEU A 127
LEU A 131
ILE A 248
ALA A 366
ARG A 378
 None
 1.22A 2v0mC-4wpzA:
30.0		 2v0mC-4wpzA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpz CYTOCHROME P450

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 SER A 249
LEU A 127
LEU A 131
ALA A 366
ARG A 378
 None
 1.07A 2v0mC-4wpzA:
30.0		 2v0mC-4wpzA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xch S-RIBOSYLHOMOCYSTEIN
E LYASE

(Streptococcus
suis) 		PF02664
(LuxS) 		5 PHE A  80
LEU A  66
LEU A  63
ALA A 111
ARG A  42
 None
 1.22A 2v0mC-4xchA:
undetectable		 2v0mC-4xchA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens) 		PF00079
(Serpin) 		5 SER A  30
LEU A 101
PHE A  92
ALA A 179
THR A 155
 None
 1.28A 2v0mC-4zk3A:
undetectable		 2v0mC-4zk3A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF13654
(AAA_32) 		5 ARG A 332
LEU A 381
ALA A 368
THR A 324
ARG A 333
 None
 1.19A 2v0mC-4zpxA:
undetectable		 2v0mC-4zpxA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		5 PHE A 284
LEU A 394
LEU A 250
PHE A 398
THR A 297
 None
 1.19A 2v0mC-5ajzA:
undetectable		 2v0mC-5ajzA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq1 GLUCOSE-6-PHOSPHATE
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		5 PHE A 219
ARG A 495
LEU A 249
ILE A 330
GLU A 239
 None
 1.28A 2v0mC-5aq1A:
undetectable		 2v0mC-5aq1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3

(Homo sapiens) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3)
PF14622
(Ribonucleas_3_3) 		5 PHE A 988
LEU A1067
LEU A1068
ILE A1048
ALA A1060
 None
 1.11A 2v0mC-5b16A:
undetectable		 2v0mC-5b16A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		5 PHE A 500
LEU A 413
ILE A 767
ALA A 669
ARG A 496
 None
 1.28A 2v0mC-5by3A:
undetectable		 2v0mC-5by3A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		5 SER A 482
LEU A 512
ALA A 464
ARG A 418
GLU A 438
 None
 1.17A 2v0mC-5ddsA:
undetectable		 2v0mC-5ddsA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlk TQAA

(Penicillium
aethiopicum) 		PF00668
(Condensation) 		5 LEU A 350
LEU A 351
ILE A 475
ALA A 470
THR A 469
 None
 1.03A 2v0mC-5dlkA:
undetectable		 2v0mC-5dlkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej3 ENDO-1,4-BETA-XYLANA
SE B

(Streptomyces
lividans) 		PF00457
(Glyco_hydro_11) 		5 SER A 138
LEU A 165
ILE A 116
ALA A 157
ARG A  59
 None
 1.28A 2v0mC-5ej3A:
undetectable		 2v0mC-5ej3A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc8 PRENYLTRANSFERENCE
FOR PROTEIN

(Lavandula
lanata) 		PF01255
(Prenyltransf) 		5 LEU A 246
PHE A 258
ILE A  75
ALA A 249
THR A 271
 None
 1.05A 2v0mC-5hc8A:
undetectable		 2v0mC-5hc8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 5 PHE C 882
ALA C 627
THR C 819
MET C 793
ARG C 891
 None
 1.28A 2v0mC-5hr4C:
undetectable		 2v0mC-5hr4C:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 173
LEU A 175
PHE A 394
ILE A 421
ALA A 166
 None
 1.20A 2v0mC-5i51A:
undetectable		 2v0mC-5i51A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk0 TYROSINE RECOMBINASE
XERH

(Helicobacter
pylori) 		PF00589
(Phage_integrase) 		5 LEU A 274
LEU A 220
PHE A 275
ILE A 253
THR A 233
 None
 1.19A 2v0mC-5jk0A:
undetectable		 2v0mC-5jk0A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs MICROTUBULE
INTEGRITY PROTEIN
MAL3

(Schizosaccharomyces
pombe) 		no annotation 5 LEU D  65
PHE D  69
ILE D  35
ALA D  31
GLU D  93
 None
 1.21A 2v0mC-5mjsD:
undetectable		 2v0mC-5mjsD:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT

(Escherichia
coli) 		PF03814
(KdpA) 		5 PHE A 149
LEU A  19
LEU A  23
ILE A 185
ALA A 258
 None
 1.27A 2v0mC-5mrwA:
undetectable		 2v0mC-5mrwA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 5 PHE A 312
LEU A 135
PHE A 136
ILE A 169
ALA A 179
 None
 1.26A 2v0mC-5n6vA:
undetectable		 2v0mC-5n6vA:
10.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 7 ARG A 105
SER A 119
PHE A 241
ILE A 301
ALA A 305
THR A 309
GLU A 374
 HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
RIT  A 602 (-3.9A)
RIT  A 602 ( 4.9A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 ( 4.8A)
 0.72A 2v0mC-5veuA:
48.7		 2v0mC-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 6 SER A 119
PHE A 241
ILE A 301
ALA A 305
THR A 309
ARG A 372
 RIT  A 602 (-3.7A)
RIT  A 602 (-3.9A)
RIT  A 602 ( 4.9A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
None
 0.78A 2v0mC-5veuA:
48.7		 2v0mC-5veuA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Pseudomonas
aeruginosa) 		no annotation 5 SER B  75
LEU B  48
LEU B  45
PHE B 102
ILE B  32
 None
 1.10A 2v0mC-5wybB:
undetectable		 2v0mC-5wybB:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		no annotation 5 PHE A 191
LEU A 128
LEU A 152
ILE A 114
ALA A 142
 None
 1.26A 2v0mC-5xnpA:
undetectable		 2v0mC-5xnpA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 5 ARG A 497
LEU A 479
LEU A 501
ILE A 420
ARG A 546
 None
 1.18A 2v0mC-5y3jA:
undetectable		 2v0mC-5y3jA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft -

(-) 		no annotation 5 LEU B 157
LEU B 154
ILE B 179
ALA B 182
ARG B 144
 None
 1.24A 2v0mC-6dftB:
undetectable		 2v0mC-6dftB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE

(Thermococcus
kodakarensis) 		no annotation 5 SER A 126
LEU A 105
PHE A 148
ILE A 247
GLU A 138
 None
 1.28A 2v0mC-6emsA:
undetectable		 2v0mC-6emsA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Saccharomyces
cerevisiae) 		no annotation 5 PHE U  61
SER U  73
LEU U 175
LEU U 164
ILE U 200
 None
 1.23A 2v0mC-6ezmU:
undetectable		 2v0mC-6ezmU:
11.23