SIMILAR PATTERNS OF AMINO ACIDS FOR 2V0M_B_KLNB1499_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhq CD11B

(Homo sapiens) 		PF00092
(VWA) 		4 PHE 1 275
THR 1 211
ILE 1 316
GLY 1 270
 None
 0.82A 2v0mB-1bhq1:
undetectable		 2v0mB-1bhq1:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 PHE A 207
ILE A 121
ILE A 150
GLY A  85
 None
 0.89A 2v0mB-1brwA:
0.0		 2v0mB-1brwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)

(Bacillus
subtilis) 		PF01467
(CTP_transf_like) 		4 PHE A  10
PHE A  89
ILE A  81
GLY A   8
 CTP  A 130 (-4.3A)
None
None
CTP  A 130 ( 3.8A)
 0.86A 2v0mB-1cozA:
0.0		 2v0mB-1cozA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 PHE A 247
ILE A 313
ILE A 281
GLY A 262
 None
 0.98A 2v0mB-1dq3A:
undetectable		 2v0mB-1dq3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqs PROTEIN
(3-DEHYDROQUINATE
SYNTHASE)

(Aspergillus
nidulans) 		PF01761
(DHQ_synthase) 		4 SER A  14
ILE A  15
THR A 140
GLY A 118
 None
None
NAD  A 400 (-2.7A)
None
 0.97A 2v0mB-1dqsA:
0.0		 2v0mB-1dqsA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ey2 HOMOGENTISATE
1,2-DIOXYGENASE

(Homo sapiens) 		PF04209
(HgmA) 		4 PHE A 154
ILE A 156
ILE A 190
GLY A 185
 None
 0.95A 2v0mB-1ey2A:
undetectable		 2v0mB-1ey2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 PHE A 235
ILE A 455
ILE A 534
GLY A 346
 None
 0.96A 2v0mB-1f4hA:
0.0		 2v0mB-1f4hA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00115
(COX1) 		4 ILE A 385
THR A 304
ILE A 461
GLY A 435
 None
 0.85A 2v0mB-1fftA:
0.3		 2v0mB-1fftA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7k CATALASE

(Proteus
mirabilis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 PHE A  79
ILE A  70
THR A 117
ILE A 262
 None
 0.95A 2v0mB-1h7kA:
0.0		 2v0mB-1h7kA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)

(Homo sapiens) 		PF00012
(HSP70) 		4 ILE A   7
THR A 158
ILE A  29
GLY A  12
 None
None
None
ADP  A 383 (-3.5A)
 0.86A 2v0mB-1hjoA:
undetectable		 2v0mB-1hjoA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knx PROBABLE HPR(SER)
KINASE/PHOSPHATASE

(Mycoplasma
pneumoniae) 		PF02603
(Hpr_kinase_N)
PF07475
(Hpr_kinase_C) 		4 PHE A  93
SER A  52
ILE A  50
GLY A  57
 None
 0.89A 2v0mB-1knxA:
undetectable		 2v0mB-1knxA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean pod mottle
virus) 		PF02247
(Como_LCP) 		4 SER 2 102
ILE 2 107
ILE 2  41
GLY 2 145
 None
 0.88A 2v0mB-1pgw2:
undetectable		 2v0mB-1pgw2:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szq 2-METHYLCITRATE
DEHYDRATASE

(Escherichia
coli) 		PF03972
(MmgE_PrpD) 		4 ILE A 383
THR A 313
ILE A 348
GLY A 359
 None
 1.00A 2v0mB-1szqA:
undetectable		 2v0mB-1szqA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE

(Pyrococcus
horikoshii) 		PF04587
(ADP_PFK_GK) 		4 SER A 305
THR A 126
ILE A 353
GLY A 454
 None
 0.98A 2v0mB-1u2xA:
undetectable		 2v0mB-1u2xA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm7 HYPOTHETICAL PROTEIN
AQ_1665

(Aquifex
aeolicus) 		PF12850
(Metallophos_2) 		4 PHE A  90
ILE A 177
THR A   8
ILE A 182
 None
 0.96A 2v0mB-1xm7A:
undetectable		 2v0mB-1xm7A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		4 PHE A 332
ILE A 178
ILE A 219
GLY A 184
 None
 0.85A 2v0mB-2ctzA:
undetectable		 2v0mB-2ctzA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d81 PHB DEPOLYMERASE

(Talaromyces
funiculosus) 		PF10503
(Esterase_phd) 		4 PHE A 157
ILE A 177
ILE A 257
GLY A  42
 None
 0.81A 2v0mB-2d81A:
undetectable		 2v0mB-2d81A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2c PUTATIVE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN

(Corynebacterium
diphtheriae) 		PF00994
(MoCF_biosynth) 		4 PHE A  69
ILE A   3
THR A  72
GLY A 122
 None
 0.88A 2v0mB-2g2cA:
undetectable		 2v0mB-2g2cA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU

(Streptococcus
pneumoniae) 		PF01895
(PhoU) 		4 PHE A  16
PHE A 193
ILE A  45
GLY A  20
 None
 0.82A 2v0mB-2i0mA:
undetectable		 2v0mB-2i0mA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgr YEGS

(Escherichia
coli) 		PF00781
(DAGK_cat) 		4 ILE A 136
THR A 140
ILE A  90
GLY A 207
 None
 0.80A 2v0mB-2jgrA:
undetectable		 2v0mB-2jgrA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv4 UPF0066 PROTEIN
AF_0241

(Archaeoglobus
fulgidus) 		PF01980
(UPF0066) 		4 PHE A  35
ILE A  34
ILE A 121
GLY A 115
 None
 0.93A 2v0mB-2nv4A:
undetectable		 2v0mB-2nv4A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osy ENDOGLYCOCERAMIDASE
II

(Rhodococcus sp.) 		PF00150
(Cellulase) 		4 PHE A 191
THR A 165
ILE A 276
GLY A 157
 None
 0.75A 2v0mB-2osyA:
undetectable		 2v0mB-2osyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p38 PROTEIN INVOLVED IN
RIBOSOMAL BIOGENESIS

(Pyrococcus
abyssi) 		PF03657
(UPF0113) 		4 PHE A 108
PHE A  88
ILE A  91
GLY A 143
 None
 0.97A 2v0mB-2p38A:
undetectable		 2v0mB-2p38A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzu PUTATIVE SULFATASE
YIDJ

(Bacteroides
fragilis) 		PF00884
(Sulfatase) 		4 ILE A 276
THR A  53
ILE A 261
GLY A  40
 None
 0.90A 2v0mB-2qzuA:
undetectable		 2v0mB-2qzuA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3s UNCHARACTERIZED
PROTEIN

(Nostoc
punctiforme) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 PHE A 286
PHE A 244
THR A 294
ILE A 256
 None
 0.81A 2v0mB-2r3sA:
undetectable		 2v0mB-2r3sA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfb CYTOCHROME P450

(Picrophilus
torridus) 		PF00067
(p450) 		4 PHE A  75
ILE A  80
ILE A  87
GLY A 197
 None
None
None
HEM  A 410 (-4.3A)
 0.55A 2v0mB-2rfbA:
27.5		 2v0mB-2rfbA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 PHE G1242
ILE G1219
ILE G1170
GLY G1247
 None
 0.93A 2v0mB-2uv8G:
undetectable		 2v0mB-2uv8G:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 ILE B 184
THR B  96
ILE B 324
GLY B 133
 None
SH0  A 503 (-2.9A)
None
None
 0.96A 2v0mB-2v4jB:
undetectable		 2v0mB-2v4jB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN

(Halomonas
elongata) 		PF03480
(DctP) 		4 PHE A 104
SER A  97
ILE A 100
GLY A 296
 None
 0.81A 2v0mB-2vpnA:
undetectable		 2v0mB-2vpnA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wae PENICILLIN-BINDING
PROTEIN 2B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 PHE A 604
ILE A 612
THR A 600
ILE A 645
 None
 0.79A 2v0mB-2waeA:
undetectable		 2v0mB-2waeA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		5 PHE A 800
SER A 794
ILE A 797
THR A 851
GLY A 958
 None
 1.47A 2v0mB-2xhsA:
1.5		 2v0mB-2xhsA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		4 PHE A 361
ILE A 360
ILE A 506
GLY A 444
 None
 0.75A 2v0mB-3ayfA:
undetectable		 2v0mB-3ayfA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8a HEXOKINASE-1

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 SER X 470
THR X 222
ILE X 166
GLY X 458
 None
 0.83A 2v0mB-3b8aX:
undetectable		 2v0mB-3b8aX:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 SER A  31
THR A 313
ILE A  32
GLY A  21
 None
 0.95A 2v0mB-3fefA:
undetectable		 2v0mB-3fefA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN

([Eubacterium]
rectale) 		PF13614
(AAA_31) 		4 ILE A 245
THR A 166
ILE A 352
GLY A 137
 None
None
None
ATP  A 500 (-3.2A)
 0.62A 2v0mB-3fkqA:
undetectable		 2v0mB-3fkqA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fob BROMOPEROXIDASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 PHE A 217
ILE A 219
THR A 241
GLY A  97
 None
 0.86A 2v0mB-3fobA:
undetectable		 2v0mB-3fobA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g04 HUMAN THYROID
STIMULATING
AUTOANTIBODY M22
HEAVY CHAIN
THYROTROPIN RECEPTOR

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF13306
(LRR_5) 		4 PHE C 130
ILE C  85
THR C 159
GLY B  98
 None
 0.91A 2v0mB-3g04C:
undetectable		 2v0mB-3g04C:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Clostridioides
difficile) 		PF01380
(SIS) 		4 ILE A 314
THR A 149
ILE A 212
GLY A  42
 None
None
None
CIT  A 401 ( 3.7A)
 0.66A 2v0mB-3g68A:
undetectable		 2v0mB-3g68A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl1 HEAT SHOCK PROTEIN
SSB1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		4 ILE A  10
THR A 160
ILE A  31
GLY A  15
 None
None
None
CL  A 710 ( 4.0A)
 0.88A 2v0mB-3gl1A:
undetectable		 2v0mB-3gl1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		4 ILE A 227
THR A 154
ILE A 362
GLY A 378
 None
 0.76A 2v0mB-3hbjA:
undetectable		 2v0mB-3hbjA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg6 CURF

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		4 PHE A1728
ILE A1764
THR A1731
ILE A1769
 None
 0.98A 2v0mB-3kg6A:
undetectable		 2v0mB-3kg6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgl CRUCIFERIN

(Brassica napus) 		PF00190
(Cupin_1) 		4 PHE A 368
PHE A 395
ILE A 330
ILE A 307
 None
 0.92A 2v0mB-3kglA:
undetectable		 2v0mB-3kglA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF00356
(LacI)
PF00532
(Peripla_BP_1) 		4 PHE A 188
ILE A 217
THR A 191
GLY A 279
 None
 0.96A 2v0mB-3kjxA:
undetectable		 2v0mB-3kjxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A  69
ILE A  73
THR A  62
GLY A 269
 None
 0.90A 2v0mB-3kumA:
undetectable		 2v0mB-3kumA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm3 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12979
(DUF3863)
PF12980
(DUF3864) 		4 PHE A 250
ILE A 387
THR A 247
GLY A 301
 None
 0.89A 2v0mB-3lm3A:
undetectable		 2v0mB-3lm3A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxt GLUTATHIONE S
TRANSFERASE

(Pseudomonas
protegens) 		PF13417
(GST_N_3) 		4 PHE A  42
ILE A  69
ILE A 161
GLY A   7
 None
 0.99A 2v0mB-3lxtA:
undetectable		 2v0mB-3lxtA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pet PUTATIVE ADHESIN

(Bacteroides
fragilis) 		PF10988
(DUF2807) 		4 PHE A 118
PHE A 101
ILE A  75
GLY A  50
 None
ACT  A 247 (-4.4A)
ACT  A 247 (-4.9A)
PG4  A 251 ( 4.2A)
 0.82A 2v0mB-3petA:
undetectable		 2v0mB-3petA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfe PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE FAMILY
PROTEIN

(Coccidioides
immitis) 		PF00701
(DHDPS) 		4 PHE A  55
ILE A 123
ILE A 160
GLY A  84
 None
 0.97A 2v0mB-3qfeA:
undetectable		 2v0mB-3qfeA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 PHE A 576
ILE A 574
THR A 680
GLY A 610
 None
None
UDP  A 901 (-3.2A)
None
 0.62A 2v0mB-3s29A:
undetectable		 2v0mB-3s29A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA

(Pyrococcus
furiosus) 		PF09376
(NurA) 		4 PHE A 299
ILE A 362
THR A 307
GLY A 131
 None
 0.94A 2v0mB-3talA:
undetectable		 2v0mB-3talA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2h S-LAYER PROTEIN
MA0829

(Methanosarcina
acetivorans) 		PF07752
(S-layer) 		4 PHE A 549
SER A 539
ILE A 551
GLY A 544
 None
 0.96A 2v0mB-3u2hA:
undetectable		 2v0mB-3u2hA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ug7 ARSENICAL
PUMP-DRIVING ATPASE

(Methanocaldococcus
jannaschii) 		PF02374
(ArsA_ATPase) 		4 PHE A 240
SER A  67
THR A 165
GLY A  32
 None
MG  A 403 ( 4.4A)
None
None
 0.95A 2v0mB-3ug7A:
undetectable		 2v0mB-3ug7A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwv PEROXIREDOXIN-4

(Mus musculus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 PHE A 117
THR A 218
ILE A 175
GLY A 225
 None
 0.77A 2v0mB-3vwvA:
undetectable		 2v0mB-3vwvA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 PHE A 309
ILE A  37
THR A 670
ILE A  72
 None
 0.64A 2v0mB-3wiqA:
undetectable		 2v0mB-3wiqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 PHE A 189
ILE A 172
ILE A 543
GLY A 115
 None
 1.00A 2v0mB-3zz1A:
undetectable		 2v0mB-3zz1A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 SER A1123
ILE A1121
THR A1102
ILE A1248
 None
 0.95A 2v0mB-4a4zA:
undetectable		 2v0mB-4a4zA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 SER A 260
ILE A 287
THR A 340
GLY A 439
 None
 0.86A 2v0mB-4av6A:
undetectable		 2v0mB-4av6A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		4 PHE A 240
PHE A 685
ILE A 681
ILE A 597
 None
 0.95A 2v0mB-4ckbA:
undetectable		 2v0mB-4ckbA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica) 		PF00291
(PALP) 		4 ILE A  35
THR A 315
ILE A 299
GLY A 217
 None
LLP  A  51 ( 3.4A)
None
None
 0.90A 2v0mB-4d8uA:
undetectable		 2v0mB-4d8uA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg5 PHOSPHOGLYCERATE
KINASE

(Staphylococcus
aureus) 		PF00162
(PGK) 		4 ILE A 340
THR A 301
ILE A 350
GLY A 322
 None
 0.79A 2v0mB-4dg5A:
undetectable		 2v0mB-4dg5A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eys MCCC FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF02016
(Peptidase_S66) 		4 PHE A 105
ILE A  14
THR A  83
GLY A 107
 None
 0.50A 2v0mB-4eysA:
undetectable		 2v0mB-4eysA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsf PENICILLIN-BINDING
PROTEIN 3

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 PHE A 507
SER A 302
ILE A 449
GLY A 509
 None
 0.69A 2v0mB-4fsfA:
undetectable		 2v0mB-4fsfA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gij PSEUDOURIDINE-5'-PHO
SPHATE GLYCOSIDASE

(Escherichia
coli) 		PF04227
(Indigoidine_A) 		4 ILE A 186
THR A 174
ILE A 303
GLY A 132
 None
 0.77A 2v0mB-4gijA:
undetectable		 2v0mB-4gijA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hka TRYPTOPHAN
2,3-DIOXYGENASE

(Drosophila
melanogaster) 		PF03301
(Trp_dioxygenase) 		4 PHE A 167
PHE A  68
ILE A  71
ILE A 301
 None
HEM  A 401 (-4.7A)
None
None
 0.91A 2v0mB-4hkaA:
undetectable		 2v0mB-4hkaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 PHE A 527
ILE A 579
ILE A 594
GLY A 560
 None
 0.88A 2v0mB-4hwtA:
undetectable		 2v0mB-4hwtA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN

(Homo sapiens;
Rattus
norvegicus) 		PF00012
(HSP70) 		4 ILE A   7
THR A 158
ILE A  29
GLY A  12
 None
None
None
PO4  A 603 (-3.3A)
 0.93A 2v0mB-4j8fA:
undetectable		 2v0mB-4j8fA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 PHE A 288
ILE A 446
ILE A 313
GLY A 367
 None
 0.86A 2v0mB-4l68A:
undetectable		 2v0mB-4l68A:
22.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		4 PHE A  57
SER A 119
ILE A 120
ILE A 301
 None
2QH  A 602 (-3.9A)
None
None
 0.60A 2v0mB-4ny4A:
53.2		 2v0mB-4ny4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		4 PHE A  57
SER A 119
THR A 224
ILE A 301
 None
2QH  A 602 (-3.9A)
None
None
 0.57A 2v0mB-4ny4A:
53.2		 2v0mB-4ny4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odi PHOSPHOGLYCERATE
MUTASE PGMII

(Toxoplasma
gondii) 		PF00300
(His_Phos_1) 		4 PHE A  67
ILE A  94
THR A  20
GLY A  64
 None
 0.86A 2v0mB-4odiA:
undetectable		 2v0mB-4odiA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4olq ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Hyphomonas
neptunium) 		PF00378
(ECH_1) 		4 PHE A  70
SER A  83
ILE A  73
GLY A 139
 None
 0.86A 2v0mB-4olqA:
undetectable		 2v0mB-4olqA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oon PENICILLIN-BINDING
PROTEIN 1A

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		4 PHE A 707
SER A 469
ILE A 660
GLY A 709
 None
 0.56A 2v0mB-4oonA:
undetectable		 2v0mB-4oonA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovd PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 PHE A 524
SER A 313
ILE A 466
GLY A 526
 None
 0.80A 2v0mB-4ovdA:
undetectable		 2v0mB-4ovdA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgk FATTY ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 PHE A 364
ILE A 216
THR A 384
GLY A 232
 None
 0.88A 2v0mB-4qgkA:
undetectable		 2v0mB-4qgkA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 SER B 707
THR B 924
ILE B 709
GLY B 671
 None
 0.81A 2v0mB-4qiwB:
undetectable		 2v0mB-4qiwB:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 PHE A 325
THR A  41
ILE A 377
GLY A  28
 None
 0.77A 2v0mB-4uphA:
undetectable		 2v0mB-4uphA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yai C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		4 PHE A 126
ILE A  37
ILE A  94
GLY A 122
 None
NAI  A 500 (-3.7A)
NAI  A 500 ( 4.7A)
None
 0.96A 2v0mB-4yaiA:
undetectable		 2v0mB-4yaiA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG

(Haemophilus
influenzae) 		PF03595
(SLAC1) 		4 SER A  24
THR A 302
ILE A  96
GLY A  15
 None
None
None
BOG  A 401 ( 4.2A)
 0.98A 2v0mB-4ycrA:
undetectable		 2v0mB-4ycrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7e LMO1422 PROTEIN

(Listeria
monocytogenes) 		PF04069
(OpuAC) 		4 PHE A 292
THR A 420
ILE A 502
GLY A 444
 PPI  A 601 (-3.2A)
None
None
PPI  A 601 ( 3.9A)
 0.91A 2v0mB-4z7eA:
undetectable		 2v0mB-4z7eA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 4 SER A 228
ILE A 227
THR A 119
GLY A  88
 None
 0.96A 2v0mB-5ah1A:
undetectable		 2v0mB-5ah1A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN

(Campylobacter
jejuni) 		PF07196
(Flagellin_IN)
PF07559
(FlaE) 		4 ILE A 531
THR A 441
ILE A 561
GLY A 524
 None
 0.84A 2v0mB-5az4A:
undetectable		 2v0mB-5az4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqt PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRMBL2

(Pyrococcus
furiosus) 		PF01978
(TrmB)
PF11495
(Regulator_TrmB) 		4 SER A 191
THR A 139
ILE A 194
GLY A 156
 None
 0.81A 2v0mB-5bqtA:
undetectable		 2v0mB-5bqtA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4m HYDROXYNITRILE LYASE

(Davallia
tyermannii) 		no annotation 4 PHE A 136
ILE A  26
ILE A 174
GLY A  39
 None
 0.79A 2v0mB-5e4mA:
undetectable		 2v0mB-5e4mA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		4 SER A  27
ILE A 324
ILE A  12
GLY A  22
 None
 0.93A 2v0mB-5inrA:
undetectable		 2v0mB-5inrA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1l TOXR-ACTIVATED GENE
(TAGE)

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		4 PHE A 208
THR A 227
ILE B 185
GLY B 255
 None
 0.97A 2v0mB-5j1lA:
undetectable		 2v0mB-5j1lA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		4 ILE A 322
THR A 334
ILE A  46
GLY A 314
 None
 1.00A 2v0mB-5mifA:
undetectable		 2v0mB-5mifA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 4 ILE A  11
THR A 366
ILE A  67
GLY A 268
 None
 0.95A 2v0mB-5mktA:
undetectable		 2v0mB-5mktA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 ILE A 356
THR A 361
ILE A 433
GLY A 427
 None
 0.83A 2v0mB-5n4lA:
undetectable		 2v0mB-5n4lA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oet GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 30
(GPA-GSS30-APO)

(Globodera
pallida) 		no annotation 4 PHE B 478
SER B  94
ILE B 454
GLY B 476
 None
 0.82A 2v0mB-5oetB:
undetectable		 2v0mB-5oetB:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 SER A 602
ILE A 570
ILE A 589
GLY A 545
 None
 0.99A 2v0mB-5oljA:
undetectable		 2v0mB-5oljA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 PHE A 397
PHE A 111
ILE A 293
GLY A 215
 None
 0.98A 2v0mB-5thmA:
undetectable		 2v0mB-5thmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uib OXIDOREDUCTASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF01408
(GFO_IDH_MocA) 		4 PHE A 189
ILE A 190
THR A 314
ILE A 255
 None
 0.89A 2v0mB-5uibA:
undetectable		 2v0mB-5uibA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeo CYSTEINE SYNTHASE

(Fusobacterium
nucleatum) 		no annotation 4 SER A 205
THR A 293
ILE A 213
GLY A 178
 None
PLP  A 401 (-3.4A)
None
PLP  A 401 (-3.3A)
 0.70A 2v0mB-5xeoA:
undetectable		 2v0mB-5xeoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 4 PHE A 458
SER A 434
THR A 331
GLY A 428
 None
None
HFG  A 801 (-3.4A)
None
 0.83A 2v0mB-5xioA:
undetectable		 2v0mB-5xioA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xl2 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 PHE A 121
ILE A 233
ILE A 107
GLY A 253
 None
 0.97A 2v0mB-5xl2A:
undetectable		 2v0mB-5xl2A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5znn SORTILIN

(Mus musculus) 		no annotation 4 ILE A 351
THR A 414
ILE A 325
GLY A 372
 None
 0.86A 2v0mB-5znnA:
undetectable		 2v0mB-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6an0 HISTIDINOL
DEHYDROGENASE

(Elizabethkingia
anophelis) 		PF00815
(Histidinol_dh) 		4 PHE A  34
ILE A  37
ILE A 198
GLY A 223
 None
 0.91A 2v0mB-6an0A:
undetectable		 2v0mB-6an0A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhv POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		no annotation 4 PHE A1007
PHE A 869
ILE A 778
ILE A 801
 None
 1.00A 2v0mB-6bhvA:
undetectable		 2v0mB-6bhvA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 822
ILE A  25
ILE A 357
GLY A  34
 None
 0.88A 2v0mB-6c6lA:
undetectable		 2v0mB-6c6lA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G

(Pyrococcus
furiosus) 		no annotation 4 SER C  76
THR G  63
ILE C  54
GLY A  20
 None
 0.95A 2v0mB-6cfwC:
undetectable		 2v0mB-6cfwC:
11.59