SIMILAR PATTERNS OF AMINO ACIDS FOR 2V0M_B_KLNB1498

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 PHE A 263
ILE A 331
ALA A 374
GLY A 318
LEU A 317
 None
 1.27A 2v0mB-1b25A:
0.0		 2v0mB-1b25A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d3y DNA TOPOISOMERASE VI
A SUBUNIT

(Methanocaldococcus
jannaschii) 		PF04406
(TP6A_N) 		5 SER A 146
LEU A 236
ILE A 177
GLU A 197
LEU A 262
 None
None
None
MG  A 371 (-2.5A)
None
 1.01A 2v0mB-1d3yA:
0.0		 2v0mB-1d3yA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 LEU 1 195
ILE 1 317
ALA 1 254
GLU 1 312
GLY 1 348
 None
 1.20A 2v0mB-1gt91:
undetectable		 2v0mB-1gt91:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermotoga
maritima) 		PF00218
(IGPS) 		5 ARG A   9
LEU A 207
ILE A  56
ALA A  53
GLU A  12
 None
 1.26A 2v0mB-1j5tA:
0.0		 2v0mB-1j5tA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF03623
(Focal_AT) 		5 LEU A1022
ILE A 937
ALA A1029
GLU A 957
LEU A 998
 None
 1.26A 2v0mB-1ktmA:
undetectable		 2v0mB-1ktmA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Methanothermobacter
thermautotrophicus) 		PF00483
(NTP_transferase) 		5 LEU A  38
ILE A  46
ALA A  44
GLY A 172
LEU A 173
 None
 1.12A 2v0mB-1lvwA:
0.0		 2v0mB-1lvwA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 SER A  73
ILE A  11
ALA A  37
GLY A  65
LEU A  62
 None
 1.06A 2v0mB-1qgdA:
0.0		 2v0mB-1qgdA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 LEU A 352
ILE A 336
ALA A 320
GLY A 164
LEU A 315
 None
None
None
A3P  A1302 (-3.3A)
None
 1.14A 2v0mB-1t8tA:
undetectable		 2v0mB-1t8tA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0m PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ARG A  86
LEU A 114
ILE A 192
ALA A 164
LEU A 161
 None
 1.22A 2v0mB-1u0mA:
0.0		 2v0mB-1u0mA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE

(Pyrococcus
horikoshii) 		PF04587
(ADP_PFK_GK) 		5 LEU A  52
ILE A  76
ALA A  80
GLY A 196
LEU A 195
 None
 1.06A 2v0mB-1u2xA:
0.5		 2v0mB-1u2xA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		5 SER C 566
LEU C 479
GLU C 559
GLY C 489
LEU C 493
 None
 1.29A 2v0mB-1w36C:
undetectable		 2v0mB-1w36C:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 PHE A  57
ARG A  15
ALA A  24
GLY A  34
LEU A  33
 None
 1.05A 2v0mB-1wl4A:
undetectable		 2v0mB-1wl4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 PHE A  57
ARG A  15
LEU A 206
GLY A  34
LEU A  33
 None
 1.09A 2v0mB-1wl4A:
undetectable		 2v0mB-1wl4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg0 DRP35

(Staphylococcus
aureus) 		PF08450
(SGL) 		5 ARG A 205
LEU A 196
ILE A 178
ALA A 223
GLY A 263
 None
 1.19A 2v0mB-2dg0A:
undetectable		 2v0mB-2dg0A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 136
ALA A 371
GLU A 406
GLY A 184
LEU A 180
 None
 1.21A 2v0mB-2hneA:
undetectable		 2v0mB-2hneA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A  45
ILE A  25
ALA A  87
GLY A  79
LEU A  78
 None
 1.30A 2v0mB-2i3aA:
undetectable		 2v0mB-2i3aA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ia2 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		5 SER A 114
LEU A 201
ILE A 121
GLU A 257
GLY A 197
 None
 1.20A 2v0mB-2ia2A:
undetectable		 2v0mB-2ia2A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 ARG A 557
LEU A 768
ILE A 552
ALA A 269
GLY A 565
 None
 1.01A 2v0mB-2iujA:
undetectable		 2v0mB-2iujA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvo RO SIXTY-RELATED
PROTEIN, RSR

(Deinococcus
radiodurans) 		PF05731
(TROVE) 		5 LEU A 364
ILE A 395
ALA A 391
GLY A 493
LEU A 494
 None
 0.85A 2v0mB-2nvoA:
undetectable		 2v0mB-2nvoA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		5 PHE A 188
SER A 226
ALA A 129
GLY A 179
LEU A 181
 None
 1.10A 2v0mB-2nyfA:
undetectable		 2v0mB-2nyfA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2on5 NA GLUTATHIONE
S-TRANSFERASE 2

(Necator
americanus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 SER A  72
LEU A 194
ILE A  21
ALA A  25
GLU A  84
 None
None
None
EDO  A 428 (-4.3A)
None
 1.27A 2v0mB-2on5A:
undetectable		 2v0mB-2on5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506

(Zoanthus sp.) 		PF01353
(GFP) 		5 ILE A  60
ALA A  57
GLU A 146
GLY A 175
LEU A 171
 None
 1.23A 2v0mB-2pxsA:
undetectable		 2v0mB-2pxsA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Methanosarcina
mazei) 		PF00875
(DNA_photolyase) 		5 PHE A 225
ILE A 400
ALA A 399
GLY A 371
LEU A 367
 None
 1.14A 2v0mB-2xryA:
undetectable		 2v0mB-2xryA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Methanosarcina
mazei) 		PF00875
(DNA_photolyase) 		5 PHE A 225
ILE A 419
ALA A 382
GLY A 371
LEU A 367
 None
FAD  A1463 ( 4.7A)
FAD  A1463 (-3.5A)
None
None
 1.07A 2v0mB-2xryA:
undetectable		 2v0mB-2xryA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 5 LEU A 199
ILE A 180
ALA A 189
GLY A 149
LEU A 150
 None
 1.12A 2v0mB-3a0fA:
undetectable		 2v0mB-3a0fA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgw DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 SER A 279
LEU A 213
ILE A 276
ALA A 246
GLY A 181
 None
 0.86A 2v0mB-3bgwA:
undetectable		 2v0mB-3bgwA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh0 DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF03796
(DnaB_C) 		5 SER A 279
LEU A 213
ILE A 276
ALA A 246
GLY A 181
 None
 0.95A 2v0mB-3bh0A:
undetectable		 2v0mB-3bh0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		5 SER A 151
ILE A 139
ALA A 213
GLY A 192
LEU A 187
 None
 1.12A 2v0mB-3bptA:
undetectable		 2v0mB-3bptA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9w PUTATIVE
ACETYLTRANSFERASE

(Nocardia
farcinica) 		PF00797
(Acetyltransf_2) 		5 ARG A  95
ALA A  20
GLU A  94
GLY A  87
LEU A  88
 None
 1.21A 2v0mB-3d9wA:
undetectable		 2v0mB-3d9wA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3del ARGININE BINDING
PROTEIN

(Chlamydia
trachomatis) 		PF00497
(SBP_bac_3) 		5 ILE B  98
ALA B  96
GLU B 239
GLY B  72
LEU B  71
 None
 1.14A 2v0mB-3delB:
undetectable		 2v0mB-3delB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 PHE A 147
LEU A 209
ILE A 220
GLU A 524
GLY A 176
 None
 1.04A 2v0mB-3dmyA:
undetectable		 2v0mB-3dmyA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2s PROLINE
DEHYDROGENASE

(Escherichia
coli) 		PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		5 ILE A 495
ALA A 493
GLU A 559
GLY A 517
LEU A 520
 None
None
FAD  A2001 (-2.8A)
None
None
 1.12A 2v0mB-3e2sA:
undetectable		 2v0mB-3e2sA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8l SERINE PROTEINASE
INHIBITOR A

(Sagittaria
sagittifolia) 		PF00197
(Kunitz_legume) 		5 LEU C  38
ALA C  50
GLU C 167
GLY C 163
LEU C 162
 None
 1.26A 2v0mB-3e8lC:
undetectable		 2v0mB-3e8lC:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN

(Homo sapiens) 		PF08324
(PUL) 		5 LEU A 647
ILE A 698
ALA A 701
GLU A 734
LEU A 728
 None
 1.29A 2v0mB-3ebbA:
undetectable		 2v0mB-3ebbA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emk GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		5 ILE A 140
ALA A 181
GLU A 186
GLY A  17
LEU A  18
 None
 1.27A 2v0mB-3emkA:
undetectable		 2v0mB-3emkA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4f (+)-DELTA-CADINENE
SYNTHASE ISOZYME XC1

(Gossypium
arboreum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 SER A 161
LEU A 201
ILE A 175
GLU A 123
GLY A 208
 None
 1.18A 2v0mB-3g4fA:
undetectable		 2v0mB-3g4fA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum) 		PF13458
(Peripla_BP_6) 		5 LEU A 222
ILE A 144
ALA A 142
GLY A 217
LEU A 218
 None
 1.06A 2v0mB-3ipcA:
undetectable		 2v0mB-3ipcA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y BL21

(Homo sapiens) 		PF00829
(Ribosomal_L21p) 		5 LEU S  95
ILE S  87
ALA S 201
GLY S 145
LEU S 149
 None
 1.26A 2v0mB-3j7yS:
undetectable		 2v0mB-3j7yS:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jua TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-3

(Mus musculus) 		no annotation 5 LEU A 424
ALA A 285
GLU A 336
GLY A 273
LEU A 277
 None
 1.30A 2v0mB-3juaA:
undetectable		 2v0mB-3juaA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1i FLAGELLAR PROTEIN

(Helicobacter
pylori) 		PF02561
(FliS) 		5 LEU A  91
ILE A  31
ALA A 110
GLY A  82
LEU A  83
 None
 1.30A 2v0mB-3k1iA:
undetectable		 2v0mB-3k1iA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ka7 OXIDOREDUCTASE

(Methanosarcina
mazei) 		PF01593
(Amino_oxidase) 		5 ILE A  78
ALA A  66
GLU A 203
GLY A  11
LEU A  14
 None
None
None
FAD  A 500 (-3.3A)
None
 1.16A 2v0mB-3ka7A:
undetectable		 2v0mB-3ka7A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke6 PROTEIN
RV1364C/MT1410

(Mycobacterium
tuberculosis) 		PF07228
(SpoIIE)
PF13581
(HATPase_c_2) 		5 LEU A 324
ILE A 368
ALA A 179
GLY A 265
LEU A 207
 None
 1.01A 2v0mB-3ke6A:
undetectable		 2v0mB-3ke6A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kqf ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00378
(ECH_1) 		5 LEU A 117
ILE A  88
ALA A 145
GLY A 133
LEU A 134
 None
 1.22A 2v0mB-3kqfA:
undetectable		 2v0mB-3kqfA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljn HYPOTHETICAL PROTEIN

(Leishmania
major) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 PHE A 179
ARG A 120
ALA A  90
GLY A 143
LEU A 144
 None
 1.21A 2v0mB-3ljnA:
undetectable		 2v0mB-3ljnA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		5 ARG A 324
SER A 360
LEU A 200
ALA A 320
GLY A 209
 None
 1.21A 2v0mB-3lvvA:
undetectable		 2v0mB-3lvvA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6a ATP-DEPENDENT
PROTEASE LA 1

(Bacillus
subtilis) 		PF00004
(AAA)
PF05362
(Lon_C) 		5 ILE A 664
ALA A 685
GLU A 704
GLY A 709
LEU A 761
 None
 1.16A 2v0mB-3m6aA:
undetectable		 2v0mB-3m6aA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5f N-CARBAMOYL-L-AMINO
ACID HYDROLASE

(Geobacillus
stearothermophilus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A 265
ILE A 219
GLU A 251
GLY A 260
LEU A 283
 None
 1.23A 2v0mB-3n5fA:
undetectable		 2v0mB-3n5fA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 SER A 237
LEU A 332
ILE A 285
ALA A 329
LEU A 405
 None
 1.22A 2v0mB-3ngoA:
undetectable		 2v0mB-3ngoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz APC VARIANT PROTEIN

(Homo sapiens) 		PF00514
(Arm) 		5 SER A 643
LEU A 662
ALA A 680
GLY A 618
LEU A 620
 None
 1.29A 2v0mB-3nmzA:
undetectable		 2v0mB-3nmzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Arachis
duranensis;
Escherichia
coli) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		5 ILE A1109
ALA A1105
GLU A1086
GLY A1138
LEU A1139
 None
 1.17A 2v0mB-3ob4A:
undetectable		 2v0mB-3ob4A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow2 50S RIBOSOMAL
PROTEIN L2P

(Haloarcula
marismortui) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		5 LEU A  67
ILE A  45
ALA A  70
GLY A  40
LEU A  80
 None
 1.26A 2v0mB-3ow2A:
undetectable		 2v0mB-3ow2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6d PROLINE DIPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ILE A  76
ALA A 109
GLU A  94
GLY A  18
LEU A  91
 None
 1.28A 2v0mB-3q6dA:
undetectable		 2v0mB-3q6dA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsi PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 LEU A 169
ILE A 154
ALA A 159
GLY A 111
LEU A 133
 None
None
None
IOD  A 263 ( 4.1A)
None
 1.18A 2v0mB-3rsiA:
undetectable		 2v0mB-3rsiA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trr PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 LEU A 109
ILE A 124
ALA A 102
GLY A  80
LEU A  81
 None
 1.11A 2v0mB-3trrA:
undetectable		 2v0mB-3trrA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u88 HISTONE-LYSINE
N-METHYLTRANSFERASE
2A
LENS
EPITHELIUM-DERIVED
GROWTH FACTOR

(Homo sapiens) 		PF11467
(LEDGF)
no annotation 		5 PHE M 133
LEU C 383
ALA C 376
GLU C 395
LEU C 400
 None
 1.14A 2v0mB-3u88M:
undetectable		 2v0mB-3u88M:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 PHE A 349
ARG A 399
ALA A 320
GLY A 395
LEU A 372
 None
 0.97A 2v0mB-3v4cA:
undetectable		 2v0mB-3v4cA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v76 FLAVOPROTEIN

(Sinorhizobium
meliloti) 		PF03486
(HI0933_like) 		5 LEU A 193
ALA A 240
GLU A 252
GLY A 331
LEU A 196
 None
 1.13A 2v0mB-3v76A:
undetectable		 2v0mB-3v76A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx6 E1

(Kluyveromyces
marxianus) 		PF16420
(ATG7_N) 		5 SER A 219
ILE A 245
ALA A 146
GLY A 101
LEU A 253
 None
 1.19A 2v0mB-3vx6A:
undetectable		 2v0mB-3vx6A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 5 ARG A 122
LEU A 172
ALA A 202
GLU A  98
GLY A 213
 SO4  A 802 (-3.8A)
None
None
SO4  A 802 (-3.7A)
None
 1.06A 2v0mB-3wevA:
undetectable		 2v0mB-3wevA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 LEU A 503
ILE A 544
ALA A 498
GLY A 608
LEU A 607
 None
 1.26A 2v0mB-3wiqA:
undetectable		 2v0mB-3wiqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3

(Homo sapiens) 		PF01399
(PCI) 		5 LEU C 107
ILE C 141
ALA C 127
GLY C  57
LEU C  56
 None
 1.23A 2v0mB-4d10C:
undetectable		 2v0mB-4d10C:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48

(Caldicellulosiruptor
bescii) 		PF02011
(Glyco_hydro_48) 		5 LEU A  63
ILE A 620
ALA A 616
GLU A 539
GLY A  26
 None
 1.23A 2v0mB-4el8A:
undetectable		 2v0mB-4el8A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		5 LEU A 200
ILE A 219
ALA A 246
GLU A 231
GLY A 205
 None
 1.30A 2v0mB-4fs7A:
undetectable		 2v0mB-4fs7A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5u PROBABLE HYDROLASE
NIT2

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		5 LEU A   5
ILE A 266
ALA A 281
GLY A 162
LEU A 161
 None
 1.14A 2v0mB-4h5uA:
undetectable		 2v0mB-4h5uA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N) 		5 LEU M 394
ALA M 384
GLU L 132
GLY L 168
LEU L 171
 None
 1.29A 2v0mB-4heaM:
undetectable		 2v0mB-4heaM:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6f PUTATIVE ALCOHOL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 350
LEU A 203
ILE A 320
GLY A 352
LEU A 328
 None
 1.18A 2v0mB-4j6fA:
undetectable		 2v0mB-4j6fA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		5 ILE A 321
ALA A 612
GLU A 599
GLY A 177
LEU A 271
 None
None
ZN  A1102 ( 4.9A)
None
None
 1.25A 2v0mB-4k0eA:
undetectable		 2v0mB-4k0eA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4koa 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A 175
ALA A 316
GLU A 305
GLY A 103
LEU A 100
 None
 1.27A 2v0mB-4koaA:
undetectable		 2v0mB-4koaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0h CONSERVED
HYPOTHETICAL
PROTEIN, PUTATIVE
ANTI-SIGMA FACTOR

(Parabacteroides
distasonis) 		PF04773
(FecR)
PF16344
(DUF4974) 		5 ARG A 281
LEU A 312
ILE A 276
GLY A 264
LEU A 265
 None
 1.27A 2v0mB-4m0hA:
undetectable		 2v0mB-4m0hA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mla CYTOKININ OXIDASE 2

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		5 LEU A 503
ILE A 192
ALA A 214
GLU A 137
GLY A  97
 None
None
None
None
FAD  A 601 (-3.4A)
 1.23A 2v0mB-4mlaA:
undetectable		 2v0mB-4mlaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmp SIALIC ACID BINDING
PROTEIN

(Pasteurella
multocida) 		PF03480
(DctP) 		5 SER A  95
ALA A  71
GLU A 302
GLY A 107
LEU A 108
 None
 1.24A 2v0mB-4mmpA:
undetectable		 2v0mB-4mmpA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A

(Burkholderia
glumae) 		PF05853
(BKACE) 		5 LEU A 455
ILE A 397
ALA A 377
GLY A 464
LEU A 465
 None
 1.02A 2v0mB-4nnbA:
undetectable		 2v0mB-4nnbA:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 PHE A  57
ARG A 105
LEU A 210
ILE A 301
ALA A 305
 None
HEM  A 601 ( 2.8A)
None
None
2QH  A 602 ( 3.6A)
 1.01A 2v0mB-4ny4A:
53.2		 2v0mB-4ny4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		6 PHE A  57
ARG A 105
SER A 119
ILE A 301
ALA A 305
GLU A 374
 None
HEM  A 601 ( 2.8A)
2QH  A 602 (-3.9A)
None
2QH  A 602 ( 3.6A)
2QH  A 602 ( 4.8A)
 0.61A 2v0mB-4ny4A:
53.2		 2v0mB-4ny4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		5 ARG B 290
LEU B 125
ALA B 147
GLY B 156
LEU B 152
 None
 1.04A 2v0mB-4o27B:
undetectable		 2v0mB-4o27B:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwu MODULATOR PROTEIN
MZRA

(Klebsiella
pneumoniae) 		PF13721
(SecD-TM1) 		5 LEU A  94
ILE A  65
ALA A  89
GLU A  36
LEU A 106
 None
 1.02A 2v0mB-4pwuA:
undetectable		 2v0mB-4pwuA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr5 NEPRILYSIN

(Oryctolagus
cuniculus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 LEU A 200
ILE A 358
ALA A 286
GLY A 225
LEU A 224
 None
 1.18A 2v0mB-4zr5A:
undetectable		 2v0mB-4zr5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF00348
(polyprenyl_synt) 		5 SER A  56
LEU A 291
ALA A 286
GLY A 217
LEU A 216
 None
 1.09A 2v0mB-5aypA:
1.8		 2v0mB-5aypA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		5 LEU A 357
ILE A 303
GLU A 291
GLY A 334
LEU A 335
 None
 1.04A 2v0mB-5c1bA:
undetectable		 2v0mB-5c1bA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cpg (R)-SPECIFIC
ENOYL-COA HYDRATASE

(Pseudomonas
aeruginosa) 		PF01575
(MaoC_dehydratas) 		5 PHE A  90
SER A  22
LEU A  31
ALA A  25
GLY A  61
 None
 1.01A 2v0mB-5cpgA:
undetectable		 2v0mB-5cpgA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn8 GTPASE DER

(Coxiella
burnetii) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		5 PHE A  19
ILE A 181
ALA A 254
GLY A  43
LEU A  53
 None
 1.22A 2v0mB-5dn8A:
undetectable		 2v0mB-5dn8A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5emw TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-5

(Homo sapiens) 		no annotation 5 LEU A 435
ALA A 296
GLU A 347
GLY A 284
LEU A 288
 None
 1.30A 2v0mB-5emwA:
undetectable		 2v0mB-5emwA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5goo ALKALINE INVERTASE

(Nostoc sp. PCC
7120) 		PF12899
(Glyco_hydro_100) 		5 LEU A 215
ILE A 135
ALA A 210
GLY A 230
LEU A 232
 None
 1.07A 2v0mB-5gooA:
undetectable		 2v0mB-5gooA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs7 CHOLOYLGLYCINE
HYDROLASE

(Enterococcus
faecalis) 		PF02275
(CBAH) 		5 SER A 234
ILE A 250
ALA A 227
GLY A 211
LEU A 214
 None
 1.20A 2v0mB-5gs7A:
undetectable		 2v0mB-5gs7A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Kribbella
flavida) 		PF13416
(SBP_bac_8) 		5 SER A 324
LEU A 333
ALA A 328
GLY A 151
LEU A 122
 None
 0.94A 2v0mB-5ixpA:
undetectable		 2v0mB-5ixpA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7

(Saccharomyces
cerevisiae) 		PF00160
(Pro_isomerase)
PF00515
(TPR_1) 		5 LEU A  40
ILE A 191
ALA A  73
GLY A 162
LEU A 129
 None
 1.20A 2v0mB-5jheA:
undetectable		 2v0mB-5jheA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 5 PHE B 188
SER B 226
ALA B 129
GLY B 179
LEU B 181
 None
 1.05A 2v0mB-5ltmB:
undetectable		 2v0mB-5ltmB:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp7 RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Mycolicibacterium
smegmatis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 ARG A 104
LEU A 228
ILE A 233
ALA A 258
GLY A 180
 None
 1.29A 2v0mB-5mp7A:
undetectable		 2v0mB-5mp7A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT

(Escherichia
coli) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 LEU B 262
ILE B 590
ALA B 620
GLY B  42
LEU B  72
 None
 1.12A 2v0mB-5mrwB:
undetectable		 2v0mB-5mrwB:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 5 PHE A 312
LEU A 135
ILE A 169
ALA A 179
LEU A 283
 None
 1.14A 2v0mB-5n6vA:
undetectable		 2v0mB-5n6vA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npy FLAGELLAR BASAL BODY
PROTEIN

(Helicobacter
pylori) 		no annotation 5 LEU A 248
ILE A 229
ALA A 242
GLU A 270
GLY A 272
 None
 1.21A 2v0mB-5npyA:
undetectable		 2v0mB-5npyA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nva PUTATIVE
SODIUM:SOLUTE
SYMPORTER

(Proteus
mirabilis) 		no annotation 5 PHE A 131
SER A 468
LEU A 456
ALA A 449
LEU A 413
 None
 1.29A 2v0mB-5nvaA:
undetectable		 2v0mB-5nvaA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 SER A1333
LEU A1313
ILE A1363
ALA A1367
LEU A1373
 None
 1.28A 2v0mB-5t8vA:
undetectable		 2v0mB-5t8vA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrv PROTEIN REGULATED BY
ACID PH

(Agrobacterium
fabrum) 		PF09924
(DUF2156) 		5 LEU A 626
ILE A 577
ALA A 588
GLY A 634
LEU A 635
 None
 1.05A 2v0mB-5vrvA:
undetectable		 2v0mB-5vrvA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrv PROTEIN REGULATED BY
ACID PH

(Agrobacterium
fabrum) 		PF09924
(DUF2156) 		5 SER A 709
ILE A 856
ALA A 852
GLY A 641
LEU A 640
 None
 1.05A 2v0mB-5vrvA:
undetectable		 2v0mB-5vrvA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE

(Bacillus
licheniformis) 		no annotation 5 ILE A 387
ALA A 332
GLU A 356
GLY A 347
LEU A 348
 ILE  A 387 ( 0.7A)
ALA  A 332 ( 0.0A)
GLU  A 356 ( 0.5A)
GLY  A 347 ( 0.0A)
LEU  A 348 ( 0.5A)
 1.18A 2v0mB-5xluA:
undetectable		 2v0mB-5xluA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 5 ARG A 114
LEU A 127
ALA A 149
GLY A 158
LEU A 154
 None
 1.26A 2v0mB-6ao5A:
undetectable		 2v0mB-6ao5A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 5 SER A 921
LEU A 856
ILE A 897
GLY A 846
LEU A 875
 None
 1.10A 2v0mB-6b3eA:
undetectable		 2v0mB-6b3eA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 5 ILE A 774
ALA A 756
GLU A 715
GLY A 781
LEU A 829
 None
 1.23A 2v0mB-6czaA:
undetectable		 2v0mB-6czaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE

(Homo sapiens) 		no annotation 5 PHE A 450
ALA A 166
GLU A 374
GLY A  99
LEU A 100
 None
 1.26A 2v0mB-6dd3A:
undetectable		 2v0mB-6dd3A:
9.58