SIMILAR PATTERNS OF AMINO ACIDS FOR 2V0M_A_KLNA1501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1att ANTITHROMBIN III

(Bos taurus) 		PF00079
(Serpin) 		5 SER A  83
ILE A 220
LEU A 273
THR A 281
GLY A 425
 None
 1.33A 2v0mA-1attA:
0.0		 2v0mA-1attA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 SER A 110
ILE A 121
LEU A 361
ILE A 150
GLY A  88
 PO4  A2001 ( 3.2A)
None
None
None
CA  A3001 (-3.4A)
 1.11A 2v0mA-1brwA:
0.0		 2v0mA-1brwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		5 PHE A  46
SER A 490
ILE A 499
LEU A  98
GLY A 166
 None
 1.23A 2v0mA-1eyyA:
undetectable		 2v0mA-1eyyA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE

(Weissella
confusa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ASP A 171
ILE A 257
THR A 172
ILE A  24
GLY A 165
 None
 1.22A 2v0mA-1hyhA:
0.0		 2v0mA-1hyhA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		5 SER A 237
ILE A 214
LEU A 102
ILE A 230
GLY A 175
 None
 1.37A 2v0mA-1idjA:
undetectable		 2v0mA-1idjA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ASP A  99
SER A  19
ILE A  23
THR A 110
GLY A  91
 None
 1.39A 2v0mA-1itzA:
0.0		 2v0mA-1itzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
horikoshii) 		PF01470
(Peptidase_C15) 		5 PHE A   8
ILE A 193
LEU A  50
THR A 146
GLY A   7
 None
 1.36A 2v0mA-1iu8A:
0.0		 2v0mA-1iu8A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		5 ASP A 354
SER A 334
ILE A 347
LEU A  54
GLY A  84
 None
 1.37A 2v0mA-1k1xA:
undetectable		 2v0mA-1k1xA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9g CONSERVED
HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF03167
(UDG) 		5 PHE A  59
ILE A 157
LEU A 166
ILE A 148
GLY A  45
 None
 1.28A 2v0mA-1l9gA:
undetectable		 2v0mA-1l9gA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7f CAMP-DEPENDENT RAP1
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP) 		5 ILE A 104
PHE A  71
LEU A  64
ILE A 388
GLY A 114
 None
 1.22A 2v0mA-1o7fA:
undetectable		 2v0mA-1o7fA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuu ACETATE KINASE

(Methanosarcina
thermophila) 		PF00871
(Acetate_kinase) 		5 ASP A 283
ILE A 343
LEU A 275
ILE A 313
GLY A 212
 ADP  A 401 (-3.7A)
None
None
None
SO4  A 400 (-3.4A)
 1.30A 2v0mA-1tuuA:
undetectable		 2v0mA-1tuuA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori) 		PF01264
(Chorismate_synt) 		5 ASP A  35
ARG A 144
ILE A 148
ILE A 289
GLY A 136
 None
 1.37A 2v0mA-1umfA:
undetectable		 2v0mA-1umfA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzg MAJOR ENVELOPE
PROTEIN E

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		5 ILE A 318
LEU A  41
THR A  32
ILE A 387
GLY A 146
 None
 1.32A 2v0mA-1uzgA:
undetectable		 2v0mA-1uzgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG

(Homo sapiens) 		PF08423
(Rad51) 		5 ASP A 337
ILE A 116
LEU A 310
ILE A 221
GLY A 334
 None
 1.29A 2v0mA-1v5wA:
undetectable		 2v0mA-1v5wA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE

(Bos taurus) 		PF00587
(tRNA-synt_2b) 		5 ASP A  42
ARG A 414
ILE A 418
ILE A 303
GLY A 343
 None
 1.15A 2v0mA-1wleA:
0.8		 2v0mA-1wleA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
furiosus) 		PF01470
(Peptidase_C15) 		5 PHE A   8
ILE A 200
LEU A 148
ILE A  29
GLY A   7
 None
 1.14A 2v0mA-1z8wA:
undetectable		 2v0mA-1z8wA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zca G ALPHA I/12

(Mus musculus) 		PF00503
(G-alpha) 		5 ASP A 334
ARG A 337
SER A 245
ILE A 246
ILE A  58
 None
 1.17A 2v0mA-1zcaA:
undetectable		 2v0mA-1zcaA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL
SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF08442
(ATP-grasp_2) 		5 ASP B 226
ARG A 256
ILE A 218
THR B 201
ILE A 246
 None
 1.30A 2v0mA-2fpgB:
undetectable		 2v0mA-2fpgB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 PHE A 373
ILE A 312
PHE A 387
LEU A 398
GLY A 389
 None
 1.11A 2v0mA-2fuvA:
undetectable		 2v0mA-2fuvA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i34 ACID PHOSPHATASE

(Bacillus
anthracis) 		PF03767
(Acid_phosphat_B) 		5 ILE A 174
PHE A 109
LEU A 103
THR A  69
GLY A  44
 None
 1.31A 2v0mA-2i34A:
undetectable		 2v0mA-2i34A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		5 PHE A  62
ARG A 370
THR A 390
ILE A 212
GLY A  77
 None
 1.35A 2v0mA-2i3oA:
0.4		 2v0mA-2i3oA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		5 ASP A 139
SER A 151
ILE A 119
LEU A 136
ILE A 153
 None
 1.31A 2v0mA-2i9uA:
undetectable		 2v0mA-2i9uA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg7 ANTIQUITIN

(Acanthopagrus
schlegelii) 		PF00171
(Aldedh) 		5 PHE A 400
ILE A 451
PHE A 167
THR A 244
ILE A 456
 NAD  A1510 (-3.8A)
None
None
NAD  A1510 (-4.1A)
None
 1.37A 2v0mA-2jg7A:
undetectable		 2v0mA-2jg7A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p10 MLL9387 PROTEIN

(Mesorhizobium
japonicum) 		PF09370
(PEP_hydrolase) 		5 ILE A 185
LEU A  70
THR A 129
ILE A  29
GLY A 233
 None
ACT  A 286 (-3.7A)
None
None
None
 1.25A 2v0mA-2p10A:
undetectable		 2v0mA-2p10A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		5 ILE B 188
LEU B 502
THR B 252
ILE B 215
GLY B 507
 None
 1.25A 2v0mA-2pffB:
undetectable		 2v0mA-2pffB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		5 ARG A  53
LEU A 362
THR A  65
ILE A 228
GLY A 354
 BEZ  A 501 ( 4.1A)
None
None
None
None
 1.30A 2v0mA-2q6uA:
undetectable		 2v0mA-2q6uA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		5 ASP A 457
ILE A 478
PHE A 485
ILE A 541
GLY A 500
 None
 1.28A 2v0mA-2x24A:
undetectable		 2v0mA-2x24A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Bacillus
subtilis) 		PF01008
(IF-2B) 		5 ASP A 135
LEU A 274
THR A 138
ILE A 189
GLY A 238
 None
 1.29A 2v0mA-2yrfA:
undetectable		 2v0mA-2yrfA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE

(Entamoeba
histolytica) 		PF01053
(Cys_Met_Meta_PP) 		5 SER A 218
ILE A 198
PHE A 115
THR A 131
ILE A 229
 None
 1.32A 2v0mA-3aczA:
undetectable		 2v0mA-3aczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcq ALPHA-CHAIN
HEMOGLOBIN

(Brycon cephalus) 		PF00042
(Globin) 		5 ILE A  74
LEU A  87
THR A  83
ILE A  10
GLY A  65
 None
 1.35A 2v0mA-3bcqA:
undetectable		 2v0mA-3bcqA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 5 PHE B  81
ILE B 273
LEU B 370
ILE B 205
GLY B  61
 None
 1.36A 2v0mA-3bxwB:
undetectable		 2v0mA-3bxwB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 SER A 282
ILE A 412
LEU A 338
ILE A 254
GLY A 392
 None
 1.23A 2v0mA-3cb5A:
undetectable		 2v0mA-3cb5A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce9 GLYCEROL
DEHYDROGENASE

(Clostridium
acetobutylicum) 		PF13685
(Fe-ADH_2) 		5 ILE A  28
PHE A  40
THR A 119
ILE A  61
GLY A  49
 None
None
EDO  A 401 (-4.0A)
None
None
 1.06A 2v0mA-3ce9A:
undetectable		 2v0mA-3ce9A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv2 MALATE SYNTHASE A

(Escherichia
coli) 		PF01274
(Malate_synthase) 		5 ASP A 447
ILE A 249
LEU A 524
ILE A 261
GLY A 169
 CSO  A 438 ( 4.8A)
None
None
None
None
 1.24A 2v0mA-3cv2A:
undetectable		 2v0mA-3cv2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3das PUTATIVE
OXIDOREDUCTASE

(Streptomyces
coelicolor) 		PF07995
(GSDH) 		5 ASP A 329
ARG A 311
ILE A 268
ILE A 288
GLY A 282
 PQQ  A4331 ( 4.9A)
PQQ  A4331 (-2.9A)
None
None
ARA  A 349 (-4.1A)
 1.30A 2v0mA-3dasA:
undetectable		 2v0mA-3dasA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzb PREPHENATE
DEHYDROGENASE

(Streptococcus
thermophilus) 		PF02153
(PDH) 		5 ASP A 182
ILE A  14
THR A 185
ILE A   8
GLY A 121
 None
 1.35A 2v0mA-3dzbA:
undetectable		 2v0mA-3dzbA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejw SMLSRB

(Sinorhizobium
meliloti) 		PF13407
(Peripla_BP_4) 		5 PHE A  15
ASP A 140
ILE A 297
PHE A   6
ILE A 271
 PAV  A 400 (-3.7A)
PAV  A 400 (-3.1A)
None
None
None
 1.28A 2v0mA-3ejwA:
undetectable		 2v0mA-3ejwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejw SMLSRB

(Sinorhizobium
meliloti) 		PF13407
(Peripla_BP_4) 		5 PHE A  15
ILE A 297
PHE A   6
ILE A 271
GLY A  19
 PAV  A 400 (-3.7A)
None
None
None
None
 1.38A 2v0mA-3ejwA:
undetectable		 2v0mA-3ejwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emq ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
barcinonensis) 		PF00331
(Glyco_hydro_10) 		5 ASP A 130
ARG A  79
ILE A  18
ILE A 328
GLY A 211
 None
 1.25A 2v0mA-3emqA:
undetectable		 2v0mA-3emqA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Thermoplasma
acidophilum) 		PF00814
(Peptidase_M22) 		5 ASP A 285
SER A  56
ILE A  55
LEU A  80
THR A   9
 MG  A 600 (-3.1A)
None
None
None
None
 1.22A 2v0mA-3enoA:
undetectable		 2v0mA-3enoA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9r PHOSPHOMANNOMUTASE

(Trypanosoma
brucei) 		PF03332
(PMM) 		5 ASP A 207
SER A 129
ILE A 177
LEU A  15
GLY A  45
 None
 1.23A 2v0mA-3f9rA:
undetectable		 2v0mA-3f9rA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N) 		5 SER A  93
ILE A  95
PHE A 334
THR A 132
GLY A 336
 None
 1.36A 2v0mA-3foaA:
undetectable		 2v0mA-3foaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0o BETA-GLUCANASE

(Fibrobacter
succinogenes) 		PF00722
(Glyco_hydro_16) 		5 PHE A 182
ILE A  73
PHE A  23
THR A 113
GLY A  21
 None
 1.32A 2v0mA-3h0oA:
undetectable		 2v0mA-3h0oA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ

(Carboxydothermus
hydrogenoformans) 		PF14450
(FtsA) 		5 ASP A  31
ILE A 150
LEU A 259
ILE A 213
GLY A 145
 ATP  A 301 (-3.7A)
None
None
None
ATP  A 301 (-3.7A)
 1.15A 2v0mA-3h1qA:
undetectable		 2v0mA-3h1qA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ASP A 376
ILE B 271
LEU A 383
ILE B 224
GLY B   9
 None
 1.35A 2v0mA-3hrdA:
undetectable		 2v0mA-3hrdA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		5 SER U  93
ILE U  95
PHE U 334
THR U 132
GLY U 336
 None
 1.36A 2v0mA-3j2nU:
undetectable		 2v0mA-3j2nU:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08454
(RIH_assoc)
PF08709
(Ins145_P3_rec) 		5 ARG A  54
SER A  16
PHE A 303
ILE A 220
GLY A 236
 None
 1.33A 2v0mA-3javA:
0.0		 2v0mA-3javA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		5 ILE A1195
PHE A1478
LEU A1454
THR A1457
ILE A1527
 None
 1.19A 2v0mA-3jroA:
undetectable		 2v0mA-3jroA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 ASP A 107
ILE A 116
LEU A 167
THR A 106
ILE A  38
 NA  A 647 (-3.2A)
None
None
NA  A 647 (-3.9A)
None
 1.24A 2v0mA-3lk6A:
undetectable		 2v0mA-3lk6A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		5 PHE A 555
ILE A 543
PHE A 574
LEU A 564
ILE A 507
 None
 1.33A 2v0mA-3mcaA:
undetectable		 2v0mA-3mcaA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nda SERPIN-2

(Ixodes ricinus) 		PF00079
(Serpin) 		5 SER A  36
ILE A 170
LEU A 224
THR A 232
GLY A 372
 None
 1.13A 2v0mA-3ndaA:
undetectable		 2v0mA-3ndaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		5 PHE A 788
ILE A 767
THR A 849
ILE A 777
GLY A 881
 None
 1.06A 2v0mA-3ob8A:
undetectable		 2v0mA-3ob8A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3u LIGNIN PEROXIDASE

(Trametopsis
cervina) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 ARG A  43
SER A 176
ILE A 177
THR A  90
GLY A 189
 HEM  A 338 (-3.6A)
CA  A 341 (-2.4A)
None
None
None
 1.35A 2v0mA-3q3uA:
undetectable		 2v0mA-3q3uA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8x METHIONYL-TRNA
FORMYLTRANSFERASE

(Yersinia pestis) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 ILE A 139
PHE A   9
LEU A  81
ILE A 137
GLY A  11
 None
 1.27A 2v0mA-3r8xA:
undetectable		 2v0mA-3r8xA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 SER A 506
ILE A 418
PHE A 458
LEU A 370
GLY A 448
 None
 1.16A 2v0mA-3s5kA:
undetectable		 2v0mA-3s5kA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfj GCVT-LIKE
AMINOMETHYLTRANSFERA
SE PROTEIN

(Candidatus
Pelagibacter
ubique) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 ILE A 302
PHE A 368
LEU A 244
ILE A 299
GLY A 294
 None
None
THG  A 370 ( 4.8A)
None
None
 1.33A 2v0mA-3tfjA:
undetectable		 2v0mA-3tfjA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2x EXODEOXYRIBONUCLEASE

(Methanothermobacter
thermautotrophicus) 		PF03372
(Exo_endo_phos) 		5 PHE A 152
ASP A 191
ARG A 220
THR A 192
GLY A 150
 None
 1.38A 2v0mA-3w2xA:
undetectable		 2v0mA-3w2xA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ypi TRIOSEPHOSPHATE
ISOMERASE

(Saccharomyces
cerevisiae) 		PF00121
(TIM) 		5 PHE A   6
SER A  50
LEU A 125
ILE A  20
GLY A   8
 None
 0.92A 2v0mA-3ypiA:
undetectable		 2v0mA-3ypiA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		5 ASP B1674
ILE B1665
PHE B1791
ILE B1775
GLY B1793
 None
 1.35A 2v0mA-3zefB:
0.0		 2v0mA-3zefB:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		5 PHE A 632
ASP A 166
SER A 652
LEU A 169
GLY A 634
 None
 1.26A 2v0mA-3zgbA:
0.0		 2v0mA-3zgbA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh2 L-LACTATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ASP A 155
ILE A 244
THR A 156
ILE A   7
GLY A 149
 None
 1.20A 2v0mA-3zh2A:
undetectable		 2v0mA-3zh2A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0m BETAINE ALDEHYDE
DEHYDROGENASE,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00171
(Aldedh) 		5 SER A 447
LEU A 256
THR A 234
ILE A 264
GLY A 440
 None
None
NAD  A1498 (-3.9A)
None
None
 1.39A 2v0mA-4a0mA:
undetectable		 2v0mA-4a0mA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		5 ASP A 371
ARG A 715
ILE A 702
LEU A 721
THR A 718
 None
GOL  A1737 (-3.3A)
None
None
None
 1.21A 2v0mA-4c1oA:
undetectable		 2v0mA-4c1oA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		5 PHE A  98
ILE A 222
LEU A 236
THR A 227
GLY A 147
 None
 1.35A 2v0mA-4cczA:
undetectable		 2v0mA-4cczA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ege DIPEPTIDASE PEPE

(Mycobacterium
ulcerans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ILE A 318
LEU A 140
THR A 137
ILE A 334
GLY A 309
 None
 1.28A 2v0mA-4egeA:
undetectable		 2v0mA-4egeA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		5 ILE A 104
PHE A  71
LEU A  64
ILE A 388
GLY A 114
 None
GOL  A1001 (-4.5A)
None
None
GOL  A1001 ( 2.8A)
 1.15A 2v0mA-4f7zA:
undetectable		 2v0mA-4f7zA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdn PROTEIN FLP

(Staphylococcus
aureus) 		PF00144
(Beta-lactamase) 		5 ASP A 170
SER A 149
ILE A 151
LEU A 259
GLY A 199
 None
 1.27A 2v0mA-4gdnA:
undetectable		 2v0mA-4gdnA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		5 PHE B 321
ASP B 370
ILE B 270
ILE B 251
GLY B 258
 None
 1.09A 2v0mA-4i0wB:
undetectable		 2v0mA-4i0wB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ict CYTOCHROME P450 121

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 ILE A 247
PHE A 314
LEU A 336
ILE A 375
GLY A 323
 None
 1.23A 2v0mA-4ictA:
26.5		 2v0mA-4ictA:
22.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		7 PHE A  57
ASP A  76
ARG A 106
SER A 119
ILE A 120
THR A 224
ILE A 301
 None
None
None
2QH  A 602 (-3.9A)
None
None
None
 0.62A 2v0mA-4ny4A:
53.2		 2v0mA-4ny4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 PHE A  57
ASP A  76
ARG A 106
THR A 224
GLY A 481
 None
 1.19A 2v0mA-4ny4A:
53.2		 2v0mA-4ny4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN

(Vibrio cholerae) 		PF00501
(AMP-binding) 		5 ASP A 247
SER A 259
ILE A 258
PHE A 369
THR A 346
 GAP  A 601 (-2.8A)
None
None
None
None
 1.38A 2v0mA-4oxiA:
undetectable		 2v0mA-4oxiA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxd ALLANTOATE
AMIDOHYDROLASE

(Escherichia
coli) 		PF01546
(Peptidase_M20) 		5 SER A 138
ILE A 141
LEU A 102
ILE A 362
GLY A  93
 None
 1.33A 2v0mA-4pxdA:
undetectable		 2v0mA-4pxdA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE

(Leishmania
major) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ASP A 301
ILE A 233
THR A  91
ILE A 206
GLY A 403
 MG  A 601 (-2.4A)
None
None
None
None
 1.37A 2v0mA-4qg5A:
undetectable		 2v0mA-4qg5A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		5 ASP A 349
ARG A 693
ILE A 680
LEU A 699
THR A 696
 None
TRS  A 803 (-3.4A)
None
None
None
 1.23A 2v0mA-4rhhA:
undetectable		 2v0mA-4rhhA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN C CHAIN

(Glossoscolex
paulistus) 		PF00042
(Globin) 		5 ASP C 127
ILE C  80
PHE C  33
ILE C 141
GLY C 121
 None
 1.38A 2v0mA-4u8uC:
undetectable		 2v0mA-4u8uC:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuo CYTOSOLIC MALATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 PHE A 107
SER A 285
LEU A   7
ILE A 181
GLY A 128
 None
 1.12A 2v0mA-4uuoA:
undetectable		 2v0mA-4uuoA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		5 ILE A 252
LEU A 266
THR A 111
ILE A 167
GLY A 282
 None
 1.30A 2v0mA-4w1wA:
undetectable		 2v0mA-4w1wA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB

(Brucella
abortus) 		PF00294
(PfkB) 		5 ASP A 249
ILE A  10
PHE A  48
LEU A  39
GLY A   6
 ANP  A 401 ( 4.3A)
None
None
None
None
 1.10A 2v0mA-4wjmA:
undetectable		 2v0mA-4wjmA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2x NS6 PROTEASE

(Norwalk virus) 		PF05416
(Peptidase_C37) 		5 PHE A  40
SER A   4
ILE A   5
LEU A  56
THR A  27
 None
 1.22A 2v0mA-4x2xA:
undetectable		 2v0mA-4x2xA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		5 PHE B  51
ARG B 148
ILE B 160
ILE B  62
GLY B  52
 None
GOL  B 802 (-4.0A)
None
None
None
 1.36A 2v0mA-4yg8B:
undetectable		 2v0mA-4yg8B:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8y RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		5 ASP A  56
ARG A  83
ILE A  85
LEU A  37
GLY A  78
 None
 1.27A 2v0mA-4z8yA:
undetectable		 2v0mA-4z8yA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8h TYPE III
PANTOTHENATE KINASE

(Burkholderia
cenocepacia) 		PF03309
(Pan_kinase) 		5 ASP A 230
ARG A 242
ILE A 124
LEU A 198
GLY A 128
 None
None
None
None
2PN  A 301 (-3.3A)
 1.37A 2v0mA-5b8hA:
undetectable		 2v0mA-5b8hA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		5 ASP A 880
SER A 624
LEU A 885
THR A 884
GLY A 868
 None
BCO  A1103 (-3.4A)
None
None
5AD  A1102 ( 3.5A)
 1.33A 2v0mA-5cjuA:
undetectable		 2v0mA-5cjuA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3

(Arabidopsis
thaliana) 		PF00311
(PEPcase) 		5 PHE A 635
ASP A 167
SER A 655
LEU A 170
GLY A 637
 None
 1.28A 2v0mA-5fdnA:
0.0		 2v0mA-5fdnA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h35 MEMBRANE PROTEIN
TRIC

(Sulfolobus
solfataricus) 		PF03458
(UPF0126) 		5 ARG C 187
SER C 160
PHE C  16
LEU C  22
GLY C 133
 None
 1.36A 2v0mA-5h35C:
undetectable		 2v0mA-5h35C:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h35 MEMBRANE PROTEIN
TRIC

(Sulfolobus
solfataricus) 		PF03458
(UPF0126) 		5 ARG C 187
SER C 160
PHE C  16
LEU C  22
GLY C 134
 None
 1.32A 2v0mA-5h35C:
undetectable		 2v0mA-5h35C:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ASP A 194
SER A 310
ILE A 321
ILE A 340
GLY A 370
 MG  A 501 ( 2.9A)
None
None
None
CAP  A 500 (-3.0A)
 1.28A 2v0mA-5hqlA:
undetectable		 2v0mA-5hqlA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnb POLY(A) RNA
POLYMERASE GLD-2
RNP (RRM RNA BINDING
DOMAIN) CONTAINING

(Caenorhabditis
elegans) 		PF03828
(PAP_assoc)
no annotation 		5 ASP A 608
SER A 688
ILE E 214
PHE E 207
LEU A 590
 MG  A1002 (-3.1A)
None
None
None
None
 1.32A 2v0mA-5jnbA:
undetectable		 2v0mA-5jnbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		5 ASP A 678
ARG A 670
ILE A 690
ILE A 581
GLY A  23
 None
 1.37A 2v0mA-5jxkA:
1.8		 2v0mA-5jxkA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ASP B 591
ILE B 585
THR B 592
ILE B 582
GLY B 430
 GNP  B 705 (-2.9A)
None
GNP  B 705 ( 4.7A)
None
GNP  B 705 (-3.1A)
 1.19A 2v0mA-5l3qB:
undetectable		 2v0mA-5l3qB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 ASP A1946
ARG A1895
SER A1558
ILE A1557
GLY A1690
 None
 1.38A 2v0mA-5m5pA:
undetectable		 2v0mA-5m5pA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nem INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		5 SER B 213
ILE B 212
PHE B 154
LEU B 139
GLY B 155
 None
 1.33A 2v0mA-5nemB:
undetectable		 2v0mA-5nemB:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swc CARBONIC ANHYDRASE

(Synechocystis
sp. PCC 6803) 		PF00484
(Pro_CA) 		5 ILE A  93
LEU A 124
THR A 127
ILE A  34
GLY A  97
 None
 1.20A 2v0mA-5swcA:
undetectable		 2v0mA-5swcA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 5 PHE A 924
SER A1493
LEU A 973
THR A 975
GLY A 956
 None
 1.38A 2v0mA-5xyaA:
undetectable		 2v0mA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybl MULTIFUNCTIONAL
DIOXYGENASE AUSE

(Aspergillus
nidulans) 		no annotation 5 ASP A  91
ARG A 259
PHE A 231
LEU A  96
ILE A 248
 None
 1.33A 2v0mA-5yblA:
undetectable		 2v0mA-5yblA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 5 ASP A 446
ILE A 492
THR A 561
ILE A 544
GLY A 571
 None
 1.28A 2v0mA-5z0uA:
undetectable		 2v0mA-5z0uA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3u ULVAN LYASE

(Nonlabens
ulvanivorans) 		no annotation 5 PHE A 136
SER A  89
ILE A  98
ILE A  91
GLY A 138
 None
 1.33A 2v0mA-6d3uA:
undetectable		 2v0mA-6d3uA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
COMPONENT RRP4
EXOSOME COMPLEX
COMPONENT RRP42

(Homo sapiens) 		no annotation 5 ASP E 213
ARG E  27
LEU E 216
THR E 215
ILE H 280
 None
 1.33A 2v0mA-6d6qE:
undetectable		 2v0mA-6d6qE:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejb XYLOSYLTRANSFERASE 1

(Homo sapiens) 		no annotation 5 PHE A 458
SER A 539
LEU A 525
THR A 524
GLY A 491
 None
 1.29A 2v0mA-6ejbA:
undetectable		 2v0mA-6ejbA:
9.71