SIMILAR PATTERNS OF AMINO ACIDS FOR 2V0M_A_KLNA1500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME


(Pseudomonas
putida)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 SER A 106
LEU A 328
ILE A 274
ALA A 315
LEU A 358
None
1.39A 2v0mA-1bkhA:
undetectable
2v0mA-1bkhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxz GLYCININ G1

(Glycine max)
PF00190
(Cupin_1)
5 SER A 145
ILE A  72
PHE A 117
GLU A  34
LEU A  55
None
1.44A 2v0mA-1fxzA:
0.0
2v0mA-1fxzA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE


(Escherichia
coli)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
5 SER A  39
LEU A  60
ALA A  45
GLU A  11
LEU A  28
None
1.42A 2v0mA-1gytA:
undetectable
2v0mA-1gytA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE


(Pseudomonas sp.
KKS102)
PF00903
(Glyoxalase)
5 SER B 254
LEU B   8
ILE B 257
PHE B 210
LEU B  22
None
1.43A 2v0mA-1kwcB:
0.9
2v0mA-1kwcB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE


(Methylosinus
trichosporium)
PF02332
(Phenol_Hydrox)
5 LEU D 204
ILE D 193
PHE D 192
ALA D 189
GLU D 460
None
1.21A 2v0mA-1mhzD:
0.0
2v0mA-1mhzD:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pca PROCARBOXYPEPTIDASE
A PCPA


(Sus scrofa)
PF00246
(Peptidase_M14)
PF02244
(Propep_M14)
5 PHE A   7
LEU A  15
PHE A 116
ARG A  55
GLU A 163
None
1.33A 2v0mA-1pcaA:
0.0
2v0mA-1pcaA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
5 LEU A 546
ILE A 701
ALA A 697
GLU A 670
LEU A 664
None
1.36A 2v0mA-1rrhA:
0.0
2v0mA-1rrhA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 LEU A 175
ILE A 424
ALA A 168
GLU A 112
LEU A 180
None
1.38A 2v0mA-1tkcA:
0.0
2v0mA-1tkcA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twd COPPER HOMEOSTASIS
PROTEIN CUTC


(Shigella
flexneri)
PF03932
(CutC)
5 PHE A  65
LEU A 134
ILE A 172
ALA A 143
ARG A  59
None
1.37A 2v0mA-1twdA:
undetectable
2v0mA-1twdA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0m PUTATIVE POLYKETIDE
SYNTHASE


(Streptomyces
coelicolor)
PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C)
5 ARG A  86
LEU A 114
ILE A 192
ALA A 164
LEU A 161
None
1.16A 2v0mA-1u0mA:
undetectable
2v0mA-1u0mA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ


(Glycine max)
PF00190
(Cupin_1)
5 ARG A 363
LEU A 210
PHE A 481
ALA A 480
LEU A 214
None
1.25A 2v0mA-1uikA:
undetectable
2v0mA-1uikA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE


(Thermotoga
maritima)
PF00180
(Iso_dh)
5 SER A 263
LEU A  91
ALA A 273
MET A 240
GLU A 135
None
1.35A 2v0mA-1vlcA:
undetectable
2v0mA-1vlcA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcg THIOGLUCOSIDASE

(Brevicoryne
brassicae)
PF00232
(Glyco_hydro_1)
5 LEU A  73
ILE A  67
ALA A  66
GLU A  21
LEU A 109
None
1.24A 2v0mA-1wcgA:
undetectable
2v0mA-1wcgA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2


(Homo sapiens)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 PHE A  57
ARG A  15
ALA A  24
MET A 119
LEU A  33
None
1.40A 2v0mA-1wl4A:
undetectable
2v0mA-1wl4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9j PROBABLE BUTYRATE
KINASE 2


(Thermotoga
maritima)
PF00871
(Acetate_kinase)
5 LEU A  65
ILE A   7
PHE A  71
ALA A 113
ARG A 347
None
1.41A 2v0mA-1x9jA:
undetectable
2v0mA-1x9jA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT


(Thermotoga
maritima)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
5 LEU A 357
ILE A 423
ALA A 427
GLU A 324
LEU A 365
None
None
None
GDP  A1002 (-2.6A)
None
1.37A 2v0mA-1xjeA:
undetectable
2v0mA-1xjeA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN


(Legionella
pneumophila)
PF01369
(Sec7)
5 LEU A  53
ILE A  27
ARG A 109
GLU A  66
LEU A  62
None
1.13A 2v0mA-1xszA:
undetectable
2v0mA-1xszA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddh ACYL-COA OXIDASE

(Rattus
norvegicus)
PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N)
5 PHE A 280
LEU A 111
ALA A 204
MET A 278
GLU A 421
None
None
None
None
HXD  A 900 (-3.5A)
1.41A 2v0mA-2ddhA:
undetectable
2v0mA-2ddhA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ee4 RHO GTPASE
ACTIVATING PROTEIN 5
VARIANT


(Homo sapiens)
PF00620
(RhoGAP)
5 LEU A 162
ILE A 142
PHE A 166
GLU A  36
LEU A  87
None
1.42A 2v0mA-2ee4A:
undetectable
2v0mA-2ee4A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2on5 NA GLUTATHIONE
S-TRANSFERASE 2


(Necator
americanus)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 SER A  72
LEU A 194
ILE A  21
ALA A  25
GLU A  84
None
None
None
EDO  A 428 (-4.3A)
None
1.13A 2v0mA-2on5A:
1.1
2v0mA-2on5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poz PUTATIVE DEHYDRATASE

(Mesorhizobium
japonicum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 SER A  56
ILE A  52
ALA A  95
ARG A  67
LEU A 100
None
1.34A 2v0mA-2pozA:
undetectable
2v0mA-2pozA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 814
ILE A 874
ALA A 731
ARG A 745
LEU A 747
None
1.38A 2v0mA-2qobA:
undetectable
2v0mA-2qobA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3c SIGNAL RECOGNITION
54 KDA PROTEIN


(Methanocaldococcus
jannaschii)
PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB)
5 PHE C 234
LEU C 185
ILE C 124
ALA C 121
LEU C 105
None
1.43A 2v0mA-2v3cC:
1.6
2v0mA-2v3cC:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL


(Homo sapiens)
PF00171
(Aldedh)
5 PHE A  76
SER A 208
LEU A  58
ILE A 157
ALA A 139
None
1.44A 2v0mA-2w8qA:
undetectable
2v0mA-2w8qA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xci 3-DEOXY-D-MANNO-2-OC
TULOSONIC ACID
TRANSFERASE


(Aquifex
aeolicus)
PF04413
(Glycos_transf_N)
5 PHE A 247
LEU A 274
ILE A 261
ALA A 260
LEU A 250
None
1.35A 2v0mA-2xciA:
undetectable
2v0mA-2xciA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE


(Thermus
thermophilus)
PF03747
(ADP_ribosyl_GH)
5 ARG A 194
LEU A 262
PHE A 232
ALA A 233
GLU A 191
None
1.42A 2v0mA-2yzwA:
undetectable
2v0mA-2yzwA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3v ARACHIN ARAH3
ISOFORM


(Arachis
hypogaea)
PF00190
(Cupin_1)
5 SER A 178
ILE A  92
PHE A 150
GLU A  54
LEU A  75
None
1.33A 2v0mA-3c3vA:
undetectable
2v0mA-3c3vA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gms PUTATIVE
NADPH:QUINONE
REDUCTASE


(Bacillus
thuringiensis)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 SER A 153
LEU A 146
ALA A 130
ARG A 185
GLU A 182
None
1.41A 2v0mA-3gmsA:
undetectable
2v0mA-3gmsA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqc DNA REPAIR PROTEIN
REV1


(Homo sapiens)
PF00817
(IMS)
PF11799
(IMS_C)
5 ILE A 610
PHE A 590
ALA A 591
GLU A 565
LEU A 557
None
1.42A 2v0mA-3gqcA:
undetectable
2v0mA-3gqcA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE


(Homo sapiens)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C)
5 PHE A 145
ALA A 142
ARG A 165
GLU A 164
LEU A 155
None
None
None
NAG  A 624 ( 4.1A)
None
1.13A 2v0mA-3h55A:
undetectable
2v0mA-3h55A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjv MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE


(Vibrio cholerae)
PF00698
(Acyl_transf_1)
5 SER A 102
LEU A  49
PHE A  38
GLU A 279
LEU A  24
None
1.27A 2v0mA-3hjvA:
undetectable
2v0mA-3hjvA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 LEU A 414
ILE A 446
ALA A 443
ARG A 334
LEU A 292
None
1.44A 2v0mA-3i8bA:
undetectable
2v0mA-3i8bA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE


(Streptococcus
pneumoniae)
PF00698
(Acyl_transf_1)
5 PHE A 269
SER A  69
ILE A  65
ALA A  13
LEU A 278
None
1.44A 2v0mA-3im8A:
undetectable
2v0mA-3im8A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1


(Homo sapiens)
PF00135
(COesterase)
5 LEU A1117
ILE A1168
ALA A1149
GLU A1225
LEU A1172
None
1.33A 2v0mA-3k9bA:
undetectable
2v0mA-3k9bA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE


(Streptomyces
coelicolor)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ARG A 445
LEU A 218
ILE A 388
ALA A 251
ARG A 270
None
1.42A 2v0mA-3krtA:
undetectable
2v0mA-3krtA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksc LEGA CLASS

(Pisum sativum)
PF00190
(Cupin_1)
5 SER A 142
ILE A  70
PHE A 114
GLU A  32
LEU A  53
None
1.22A 2v0mA-3kscA:
undetectable
2v0mA-3kscA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mem PUTATIVE SIGNAL
TRANSDUCTION PROTEIN


(Marinobacter
hydrocarbonoclasticus)
PF04073
(tRNA_edit)
PF08668
(HDOD)
5 ARG A 441
LEU A 395
ALA A 286
GLU A 437
LEU A 403
None
1.32A 2v0mA-3memA:
undetectable
2v0mA-3memA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2


(Saccharomyces
cerevisiae)
PF10193
(Telomere_reg-2)
5 LEU A 538
ILE A 510
ALA A 506
GLU A 445
LEU A 490
None
1.22A 2v0mA-3o4zA:
undetectable
2v0mA-3o4zA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7q L-FUCOSE-PROTON
SYMPORTER


(Escherichia
coli)
PF07690
(MFS_1)
5 LEU A 145
ILE A  25
PHE A  28
ALA A  29
LEU A 157
None
1.35A 2v0mA-3o7qA:
undetectable
2v0mA-3o7qA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4


(Saccharomyces
cerevisiae)
PF11701
(UNC45-central)
5 LEU A 714
PHE A 701
ALA A 702
GLU A 739
LEU A 747
None
1.41A 2v0mA-3opbA:
undetectable
2v0mA-3opbA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3peh ENDOPLASMIN HOMOLOG

(Plasmodium
falciparum)
PF00183
(HSP90)
PF02518
(HATPase_c)
5 LEU A 100
ILE A 243
PHE A  99
ALA A 197
LEU A 247
None
1.39A 2v0mA-3pehA:
undetectable
2v0mA-3pehA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnz PHOSPHOTRIESTERASE
FAMILY PROTEIN


(Listeria
monocytogenes)
PF02126
(PTE)
5 SER A 186
LEU A 195
ILE A 213
ALA A 233
ARG A 175
None
1.08A 2v0mA-3pnzA:
undetectable
2v0mA-3pnzA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6d PROLINE DIPEPTIDASE

(Bacillus
anthracis)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
5 PHE A  11
ILE A  76
ALA A 109
GLU A  94
LEU A  91
None
1.39A 2v0mA-3q6dA:
1.5
2v0mA-3q6dA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1


(Homo sapiens)
PF02854
(MIF4G)
5 ILE A 101
PHE A 104
ALA A 105
ARG A 166
LEU A 121
None
1.32A 2v0mA-3rk6A:
undetectable
2v0mA-3rk6A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N


(Escherichia
coli)
no annotation 5 PHE J  67
SER N 136
LEU N 171
ALA N 166
LEU K  35
None
1.37A 2v0mA-3rkoJ:
undetectable
2v0mA-3rkoJ:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u92 GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3


(Rattus
norvegicus)
PF10613
(Lig_chan-Glu_bd)
5 SER A 102
LEU A  40
ILE A 229
ALA A 232
LEU A 242
None
1.10A 2v0mA-3u92A:
undetectable
2v0mA-3u92A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
5 SER A 397
LEU A 385
ILE A 422
GLU A 564
LEU A 538
None
1.44A 2v0mA-3ulzA:
undetectable
2v0mA-3ulzA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4g ARGININE REPRESSOR

(Vibrio
vulnificus)
PF01316
(Arg_repressor)
PF02863
(Arg_repressor_C)
5 LEU A  95
ILE A 131
PHE A 132
ALA A 126
ARG A  48
None
1.43A 2v0mA-3v4gA:
undetectable
2v0mA-3v4gA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE


(Methanocaldococcus
jannaschii)
PF05889
(SepSecS)
5 ARG A 135
LEU A 206
ILE A 107
ALA A 111
LEU A 138
None
1.21A 2v0mA-3wksA:
undetectable
2v0mA-3wksA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Pseudomonas
aeruginosa)
PF00483
(NTP_transferase)
5 ARG A 128
SER A 124
LEU A  45
PHE A 118
LEU A 175
None
None
N5Y  A1294 (-3.7A)
None
None
1.29A 2v0mA-4asyA:
undetectable
2v0mA-4asyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhh NUCLEOPROTEIN

(California
encephalitis
orthobunyavirus)
PF00952
(Bunya_nucleocap)
5 PHE B 152
SER B  33
ALA B  38
ARG B 101
LEU B  99
None
1.31A 2v0mA-4bhhB:
undetectable
2v0mA-4bhhB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7p RALF

(Legionella
pneumophila)
PF01369
(Sec7)
5 LEU A  53
ILE A  27
ARG A 109
GLU A  66
LEU A  62
None
1.12A 2v0mA-4c7pA:
undetectable
2v0mA-4c7pA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY


(Bacillus
subtilis)
PF00171
(Aldedh)
5 PHE A 383
SER A 430
ILE A 428
ALA A 402
GLU A 253
None
1.24A 2v0mA-4dngA:
0.3
2v0mA-4dngA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE


(Trypanosoma
cruzi)
PF00348
(polyprenyl_synt)
5 LEU A 234
ILE A 336
ALA A 347
ARG A  51
LEU A 217
None
None
None
IPE  A 405 (-2.5A)
None
1.20A 2v0mA-4e1eA:
undetectable
2v0mA-4e1eA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbh PROTEIN SYNTHESIS
INHIBITOR I


(Hordeum vulgare)
PF00161
(RIP)
5 SER A  45
PHE A 236
ALA A 247
ARG A 178
LEU A 216
None
None
None
AMP  A 301 (-3.0A)
None
1.26A 2v0mA-4fbhA:
undetectable
2v0mA-4fbhA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gwn MEPRIN A SUBUNIT
BETA


(Homo sapiens)
PF00629
(MAM)
PF01400
(Astacin)
5 LEU A 448
ILE A 441
ALA A 473
ARG A 511
LEU A 501
None
1.28A 2v0mA-4gwnA:
undetectable
2v0mA-4gwnA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmk DUAL SPECIFICITY
PROTEIN PHOSPHATASE
8


(Homo sapiens)
PF00782
(DSPc)
5 SER A 228
LEU A 170
ILE A 256
ALA A 193
ARG A 207
None
1.40A 2v0mA-4jmkA:
undetectable
2v0mA-4jmkA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfn TAU-TUBULIN KINASE 1

(Homo sapiens)
PF00069
(Pkinase)
5 SER A 224
PHE A 199
ALA A 210
ARG A 240
GLU A 231
None
None
None
SO4  A 403 (-4.1A)
SO4  A 403 ( 4.9A)
1.36A 2v0mA-4nfnA:
undetectable
2v0mA-4nfnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A


(Burkholderia
glumae)
PF05853
(BKACE)
5 LEU A 455
ILE A 397
ALA A 377
GLU A 433
LEU A 465
None
1.27A 2v0mA-4nnbA:
undetectable
2v0mA-4nnbA:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
6 ARG A 105
SER A 119
LEU A 210
ILE A 301
ALA A 305
MET A 371
HEM  A 601 ( 2.8A)
2QH  A 602 (-3.9A)
None
None
2QH  A 602 ( 3.6A)
None
1.03A 2v0mA-4ny4A:
53.2
2v0mA-4ny4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
7 PHE A  57
ARG A 105
SER A 119
ILE A 301
ALA A 305
MET A 371
ARG A 372
None
HEM  A 601 ( 2.8A)
2QH  A 602 (-3.9A)
None
2QH  A 602 ( 3.6A)
None
None
0.55A 2v0mA-4ny4A:
53.2
2v0mA-4ny4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
6 PHE A  57
ARG A 105
SER A 119
ILE A 301
PHE A 304
ALA A 305
None
HEM  A 601 ( 2.8A)
2QH  A 602 (-3.9A)
None
2QH  A 602 (-3.3A)
2QH  A 602 ( 3.6A)
1.19A 2v0mA-4ny4A:
53.2
2v0mA-4ny4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
5 SER A 119
ILE A 301
ALA A 305
MET A 371
GLU A 374
2QH  A 602 (-3.9A)
None
2QH  A 602 ( 3.6A)
None
2QH  A 602 ( 4.8A)
0.74A 2v0mA-4ny4A:
53.2
2v0mA-4ny4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
5 SER A 119
ILE A 301
PHE A 304
ALA A 305
GLU A 374
2QH  A 602 (-3.9A)
None
2QH  A 602 (-3.3A)
2QH  A 602 ( 3.6A)
2QH  A 602 ( 4.8A)
1.22A 2v0mA-4ny4A:
53.2
2v0mA-4ny4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE


(Thermococcus
kodakarensis)
PF03009
(GDPD)
5 PHE A  27
LEU A  44
ALA A 117
GLU A  39
LEU A  90
None
None
None
MG  A 401 (-2.6A)
None
1.43A 2v0mA-4oecA:
undetectable
2v0mA-4oecA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B


(Drosophila
melanogaster)
PF00079
(Serpin)
5 PHE A 359
SER A  36
LEU A 229
ILE A 168
PHE A 170
None
1.41A 2v0mA-4p0fA:
undetectable
2v0mA-4p0fA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B


(Drosophila
melanogaster)
PF00079
(Serpin)
5 SER A  36
LEU A 229
ILE A 168
PHE A 170
ALA A 330
None
1.41A 2v0mA-4p0fA:
undetectable
2v0mA-4p0fA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwu MODULATOR PROTEIN
MZRA


(Klebsiella
pneumoniae)
PF13721
(SecD-TM1)
5 LEU A  94
ILE A  65
ALA A  89
GLU A  36
LEU A 106
None
0.99A 2v0mA-4pwuA:
undetectable
2v0mA-4pwuA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up7 LYSINE--TRNA LIGASE

(Entamoeba
histolytica)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
5 PHE A 191
LEU A 230
ILE A 523
ALA A 522
ARG A 242
None
1.44A 2v0mA-4up7A:
undetectable
2v0mA-4up7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax)
PF01979
(Amidohydro_1)
5 LEU A  70
ILE A 137
ALA A  99
GLU A 296
LEU A 366
None
1.42A 2v0mA-4wgxA:
undetectable
2v0mA-4wgxA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydj HEAVY CHAIN OF
ANTIBODY 44-VRC13.01
LIGHT CHAIN OF
ANTIBODY 44-VRC13.01


(Homo sapiens)
no annotation 5 ILE H  35
ALA H  93
ARG L  53
GLU H 100
LEU L  46
None
1.27A 2v0mA-4ydjH:
undetectable
2v0mA-4ydjH:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
5 PHE A 121
LEU A  88
ILE A  43
GLU A  94
LEU A 105
None
1.39A 2v0mA-4z64A:
undetectable
2v0mA-4z64A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE


(Streptomyces
platensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ILE A 909
ALA A 906
ARG A 624
GLU A 649
LEU A 619
None
1.41A 2v0mA-4zdnA:
undetectable
2v0mA-4zdnA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila)
no annotation 5 ARG A 797
LEU A 780
PHE A 777
ALA A 773
GLU A 795
None
1.36A 2v0mA-4zuzA:
2.6
2v0mA-4zuzA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila)
no annotation 5 LEU A 368
ILE A 408
ALA A 359
GLU A 375
LEU A 178
None
1.28A 2v0mA-4zuzA:
2.6
2v0mA-4zuzA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2


(Ascophyllum
nodosum)
no annotation 5 PHE A 491
SER A 524
LEU A 231
ILE A 528
GLU A 518
None
1.21A 2v0mA-5aa6A:
undetectable
2v0mA-5aa6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cws NUCLEOPORIN NSP1
NUCLEOPORIN NUP57


(Chaetomium
thermophilum)
PF05064
(Nsp1_C)
PF13874
(Nup54)
5 ARG E 197
LEU C 548
ALA E 203
ARG E 191
LEU C 541
None
1.42A 2v0mA-5cwsE:
undetectable
2v0mA-5cwsE:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dan 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE


(Thermotoga
maritima)
PF00248
(Aldo_ket_red)
5 ILE A 260
ALA A 231
ARG A 247
GLU A 249
LEU A 201
None
None
NAP  A 301 (-4.1A)
None
NAP  A 301 (-4.0A)
1.27A 2v0mA-5danA:
undetectable
2v0mA-5danA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2o FATTY ACID
O-METHYLTRANSFERASE


(Mycobacterium
marinum)
PF03492
(Methyltransf_7)
5 SER A 149
LEU A 264
ILE A 153
ALA A 154
LEU A 359
None
None
None
5UF  A 401 ( 4.9A)
None
1.44A 2v0mA-5f2oA:
undetectable
2v0mA-5f2oA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE


(Sus scrofa)
PF00135
(COesterase)
5 LEU A 100
ILE A 151
ALA A 132
GLU A 208
LEU A 155
None
1.38A 2v0mA-5fv4A:
undetectable
2v0mA-5fv4A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqq HEME-BINDING PROTEIN
2


(Homo sapiens)
PF04832
(SOUL)
5 LEU A  69
ILE A  62
PHE A  66
GLU A 191
LEU A 185
None
1.09A 2v0mA-5gqqA:
undetectable
2v0mA-5gqqA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ica PERIODIC TRYPTOPHAN
PROTEIN 2-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF04003
(Utp12)
5 PHE D 738
LEU D 791
ALA D 820
ARG D 772
LEU D 774
None
1.44A 2v0mA-5icaD:
undetectable
2v0mA-5icaD:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE


(Salpingoeca
rosetta)
PF00069
(Pkinase)
5 PHE A 296
LEU A 125
ALA A 119
GLU A 101
LEU A 210
None
1.30A 2v0mA-5ig1A:
undetectable
2v0mA-5ig1A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1


(Burkholderia
thailandensis)
PF05853
(BKACE)
5 LEU A 459
ILE A 401
ALA A 381
GLU A 437
LEU A 469
None
1.25A 2v0mA-5ikzA:
undetectable
2v0mA-5ikzA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr9 NEQ131

(Nanoarchaeum
equitans)
PF01997
(Translin)
5 LEU B 148
ILE B 172
MET B  40
GLU B 129
LEU B  89
None
1.35A 2v0mA-5jr9B:
undetectable
2v0mA-5jr9B:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfd ALLANTOIN RACEMASE

(Pseudomonas
fluorescens)
no annotation 5 ILE A  18
ALA A 184
MET A 144
GLU A  45
LEU A 149
None
1.24A 2v0mA-5lfdA:
undetectable
2v0mA-5lfdA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2


(Eremothecium
gossypii)
PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C)
5 SER A 437
LEU A 517
ILE A 433
ARG A 529
LEU A 527
None
1.38A 2v0mA-5me3A:
0.0
2v0mA-5me3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2


(Sus scrofa)
no annotation 5 LEU A 356
ILE A 348
ARG A 334
GLU A 731
LEU A 734
None
None
None
K  A1005 (-2.9A)
None
1.33A 2v0mA-5mpmA:
undetectable
2v0mA-5mpmA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2


(Sus scrofa)
no annotation 5 LEU A 356
PHE A 739
ARG A 334
GLU A 731
LEU A 734
None
None
None
K  A1005 (-2.9A)
None
1.44A 2v0mA-5mpmA:
undetectable
2v0mA-5mpmA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea)
no annotation 5 PHE A 312
ARG A  75
ILE A 169
ALA A 179
LEU A 283
None
1.26A 2v0mA-5n6vA:
undetectable
2v0mA-5n6vA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea)
no annotation 5 PHE A 312
LEU A 135
ILE A 169
ALA A 179
LEU A 283
None
1.23A 2v0mA-5n6vA:
undetectable
2v0mA-5n6vA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nva PUTATIVE
SODIUM:SOLUTE
SYMPORTER


(Proteus
mirabilis)
no annotation 5 PHE A 131
SER A 468
LEU A 456
ALA A 449
LEU A 413
None
1.33A 2v0mA-5nvaA:
0.0
2v0mA-5nvaA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C)
5 SER A1333
LEU A1313
ILE A1363
ALA A1367
LEU A1373
None
1.28A 2v0mA-5t8vA:
0.0
2v0mA-5t8vA:
16.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens)
no annotation 6 ARG A 105
SER A 119
ILE A 301
ALA A 305
GLU A 374
LEU A 481
HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
RIT  A 602 ( 4.9A)
HEM  A 601 (-3.4A)
RIT  A 602 ( 4.8A)
None
0.67A 2v0mA-5veuA:
56.5
2v0mA-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens)
no annotation 6 ARG A 105
SER A 119
ILE A 301
PHE A 304
ALA A 305
LEU A 481
HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
RIT  A 602 ( 4.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
None
0.73A 2v0mA-5veuA:
56.5
2v0mA-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens)
no annotation 6 PHE A 215
ARG A 105
ILE A 301
PHE A 304
ALA A 305
LEU A 481
RIT  A 602 (-4.0A)
HEM  A 601 (-2.8A)
RIT  A 602 ( 4.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
None
1.49A 2v0mA-5veuA:
56.5
2v0mA-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens)
no annotation 6 SER A 119
ILE A 301
PHE A 304
ALA A 305
ARG A 372
LEU A 481
RIT  A 602 (-3.7A)
RIT  A 602 ( 4.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
None
None
0.97A 2v0mA-5veuA:
56.5
2v0mA-5veuA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aoj CEG4

(Legionella
pneumophila)
no annotation 5 SER A  81
LEU A 196
PHE A  87
ARG A 184
LEU A 156
None
1.33A 2v0mA-6aojA:
undetectable
2v0mA-6aojA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ces RAS-RELATED
GTP-BINDING PROTEIN
C


(Homo sapiens)
no annotation 5 PHE C 134
ILE C 195
ALA C 199
MET C 171
GLU C 174
None
1.18A 2v0mA-6cesC:
undetectable
2v0mA-6cesC:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxd PEPTIDASE B

(Yersinia pestis)
no annotation 5 LEU A 244
ILE A 301
ALA A 191
GLU A 339
LEU A 238
None
None
None
SO4  A 501 (-2.7A)
None
1.19A 2v0mA-6cxdA:
undetectable
2v0mA-6cxdA:
10.82