SIMILAR PATTERNS OF AMINO ACIDS FOR 2V0M_A_KLNA1500_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bkh | MUCONATE LACTONIZINGENZYME (Pseudomonasputida) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | SER A 106LEU A 328ILE A 274ALA A 315LEU A 358 | None | 1.39A | 2v0mA-1bkhA:undetectable | 2v0mA-1bkhA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fxz | GLYCININ G1 (Glycine max) |
PF00190(Cupin_1) | 5 | SER A 145ILE A 72PHE A 117GLU A 34LEU A 55 | None | 1.44A | 2v0mA-1fxzA:0.0 | 2v0mA-1fxzA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gyt | CYTOSOLAMINOPEPTIDASE (Escherichiacoli) |
PF00883(Peptidase_M17)PF02789(Peptidase_M17_N) | 5 | SER A 39LEU A 60ALA A 45GLU A 11LEU A 28 | None | 1.42A | 2v0mA-1gytA:undetectable | 2v0mA-1gytA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kwc | 2,3-DIHYDROXYBIPHENYL DIOXYGENASE (Pseudomonas sp.KKS102) |
PF00903(Glyoxalase) | 5 | SER B 254LEU B 8ILE B 257PHE B 210LEU B 22 | None | 1.43A | 2v0mA-1kwcB:0.9 | 2v0mA-1kwcB:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhz | METHANEMONOOXYGENASEHYDROXYLASE (Methylosinustrichosporium) |
PF02332(Phenol_Hydrox) | 5 | LEU D 204ILE D 193PHE D 192ALA D 189GLU D 460 | None | 1.21A | 2v0mA-1mhzD:0.0 | 2v0mA-1mhzD:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pca | PROCARBOXYPEPTIDASEA PCPA (Sus scrofa) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 5 | PHE A 7LEU A 15PHE A 116ARG A 55GLU A 163 | None | 1.33A | 2v0mA-1pcaA:0.0 | 2v0mA-1pcaA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rrh | SEED LIPOXYGENASE-3 (Glycine max) |
PF00305(Lipoxygenase)PF01477(PLAT) | 5 | LEU A 546ILE A 701ALA A 697GLU A 670LEU A 664 | None | 1.36A | 2v0mA-1rrhA:0.0 | 2v0mA-1rrhA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tkc | TRANSKETOLASE (Saccharomycescerevisiae) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | LEU A 175ILE A 424ALA A 168GLU A 112LEU A 180 | None | 1.38A | 2v0mA-1tkcA:0.0 | 2v0mA-1tkcA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1twd | COPPER HOMEOSTASISPROTEIN CUTC (Shigellaflexneri) |
PF03932(CutC) | 5 | PHE A 65LEU A 134ILE A 172ALA A 143ARG A 59 | None | 1.37A | 2v0mA-1twdA:undetectable | 2v0mA-1twdA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u0m | PUTATIVE POLYKETIDESYNTHASE (Streptomycescoelicolor) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 5 | ARG A 86LEU A 114ILE A 192ALA A 164LEU A 161 | None | 1.16A | 2v0mA-1u0mA:undetectable | 2v0mA-1u0mA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uik | ALPHA PRIME SUBUNITOF BETA-CONGLYCININ (Glycine max) |
PF00190(Cupin_1) | 5 | ARG A 363LEU A 210PHE A 481ALA A 480LEU A 214 | None | 1.25A | 2v0mA-1uikA:undetectable | 2v0mA-1uikA:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vlc | 3-ISOPROPYLMALATEDEHYDROGENASE (Thermotogamaritima) |
PF00180(Iso_dh) | 5 | SER A 263LEU A 91ALA A 273MET A 240GLU A 135 | None | 1.35A | 2v0mA-1vlcA:undetectable | 2v0mA-1vlcA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wcg | THIOGLUCOSIDASE (Brevicorynebrassicae) |
PF00232(Glyco_hydro_1) | 5 | LEU A 73ILE A 67ALA A 66GLU A 21LEU A 109 | None | 1.24A | 2v0mA-1wcgA:undetectable | 2v0mA-1wcgA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wl4 | ACETYL-COENZYME AACETYLTRANSFERASE 2 (Homo sapiens) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | PHE A 57ARG A 15ALA A 24MET A 119LEU A 33 | None | 1.40A | 2v0mA-1wl4A:undetectable | 2v0mA-1wl4A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x9j | PROBABLE BUTYRATEKINASE 2 (Thermotogamaritima) |
PF00871(Acetate_kinase) | 5 | LEU A 65ILE A 7PHE A 71ALA A 113ARG A 347 | None | 1.41A | 2v0mA-1x9jA:undetectable | 2v0mA-1x9jA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xje | RIBONUCLEOTIDEREDUCTASE,B12-DEPENDENT (Thermotogamaritima) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC) | 5 | LEU A 357ILE A 423ALA A 427GLU A 324LEU A 365 | NoneNoneNoneGDP A1002 (-2.6A)None | 1.37A | 2v0mA-1xjeA:undetectable | 2v0mA-1xjeA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xsz | GUANINE NUCLEOTIDEEXCHANGE PROTEIN (Legionellapneumophila) |
PF01369(Sec7) | 5 | LEU A 53ILE A 27ARG A 109GLU A 66LEU A 62 | None | 1.13A | 2v0mA-1xszA:undetectable | 2v0mA-1xszA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ddh | ACYL-COA OXIDASE (Rattusnorvegicus) |
PF01756(ACOX)PF02770(Acyl-CoA_dh_M)PF14749(Acyl-CoA_ox_N) | 5 | PHE A 280LEU A 111ALA A 204MET A 278GLU A 421 | NoneNoneNoneNoneHXD A 900 (-3.5A) | 1.41A | 2v0mA-2ddhA:undetectable | 2v0mA-2ddhA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ee4 | RHO GTPASEACTIVATING PROTEIN 5VARIANT (Homo sapiens) |
PF00620(RhoGAP) | 5 | LEU A 162ILE A 142PHE A 166GLU A 36LEU A 87 | None | 1.42A | 2v0mA-2ee4A:undetectable | 2v0mA-2ee4A:15.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2on5 | NA GLUTATHIONES-TRANSFERASE 2 (Necatoramericanus) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | SER A 72LEU A 194ILE A 21ALA A 25GLU A 84 | NoneNoneNoneEDO A 428 (-4.3A)None | 1.13A | 2v0mA-2on5A:1.1 | 2v0mA-2on5A:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2poz | PUTATIVE DEHYDRATASE (Mesorhizobiumjaponicum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | SER A 56ILE A 52ALA A 95ARG A 67LEU A 100 | None | 1.34A | 2v0mA-2pozA:undetectable | 2v0mA-2pozA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qob | EPHRIN RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 814ILE A 874ALA A 731ARG A 745LEU A 747 | None | 1.38A | 2v0mA-2qobA:undetectable | 2v0mA-2qobA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v3c | SIGNAL RECOGNITION54 KDA PROTEIN (Methanocaldococcusjannaschii) |
PF00448(SRP54)PF02881(SRP54_N)PF02978(SRP_SPB) | 5 | PHE C 234LEU C 185ILE C 124ALA C 121LEU C 105 | None | 1.43A | 2v0mA-2v3cC:1.6 | 2v0mA-2v3cC:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w8q | SUCCINATE-SEMIALDEHYDE DEHYDROGENASE,MITOCHONDRIAL (Homo sapiens) |
PF00171(Aldedh) | 5 | PHE A 76SER A 208LEU A 58ILE A 157ALA A 139 | None | 1.44A | 2v0mA-2w8qA:undetectable | 2v0mA-2w8qA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xci | 3-DEOXY-D-MANNO-2-OCTULOSONIC ACIDTRANSFERASE (Aquifexaeolicus) |
PF04413(Glycos_transf_N) | 5 | PHE A 247LEU A 274ILE A 261ALA A 260LEU A 250 | None | 1.35A | 2v0mA-2xciA:undetectable | 2v0mA-2xciA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzw | ADP-RIBOSYLGLYCOHYDROLASE (Thermusthermophilus) |
PF03747(ADP_ribosyl_GH) | 5 | ARG A 194LEU A 262PHE A 232ALA A 233GLU A 191 | None | 1.42A | 2v0mA-2yzwA:undetectable | 2v0mA-2yzwA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c3v | ARACHIN ARAH3ISOFORM (Arachishypogaea) |
PF00190(Cupin_1) | 5 | SER A 178ILE A 92PHE A 150GLU A 54LEU A 75 | None | 1.33A | 2v0mA-3c3vA:undetectable | 2v0mA-3c3vA:18.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gms | PUTATIVENADPH:QUINONEREDUCTASE (Bacillusthuringiensis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | SER A 153LEU A 146ALA A 130ARG A 185GLU A 182 | None | 1.41A | 2v0mA-3gmsA:undetectable | 2v0mA-3gmsA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gqc | DNA REPAIR PROTEINREV1 (Homo sapiens) |
PF00817(IMS)PF11799(IMS_C) | 5 | ILE A 610PHE A 590ALA A 591GLU A 565LEU A 557 | None | 1.42A | 2v0mA-3gqcA:undetectable | 2v0mA-3gqcA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h55 | ALPHA-N-ACETYLGALACTOSAMINIDASE (Homo sapiens) |
PF16499(Melibiase_2)PF17450(Melibiase_2_C) | 5 | PHE A 145ALA A 142ARG A 165GLU A 164LEU A 155 | NoneNoneNoneNAG A 624 ( 4.1A)None | 1.13A | 2v0mA-3h55A:undetectable | 2v0mA-3h55A:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hjv | MALONYL COA-ACYLCARRIER PROTEINTRANSACYLASE (Vibrio cholerae) |
PF00698(Acyl_transf_1) | 5 | SER A 102LEU A 49PHE A 38GLU A 279LEU A 24 | None | 1.27A | 2v0mA-3hjvA:undetectable | 2v0mA-3hjvA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i8b | XYLULOSE KINASE (Bifidobacteriumadolescentis) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | LEU A 414ILE A 446ALA A 443ARG A 334LEU A 292 | None | 1.44A | 2v0mA-3i8bA:undetectable | 2v0mA-3i8bA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3im8 | MALONYL ACYL CARRIERPROTEIN TRANSACYLASE (Streptococcuspneumoniae) |
PF00698(Acyl_transf_1) | 5 | PHE A 269SER A 69ILE A 65ALA A 13LEU A 278 | None | 1.44A | 2v0mA-3im8A:undetectable | 2v0mA-3im8A:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9b | LIVERCARBOXYLESTERASE 1 (Homo sapiens) |
PF00135(COesterase) | 5 | LEU A1117ILE A1168ALA A1149GLU A1225LEU A1172 | None | 1.33A | 2v0mA-3k9bA:undetectable | 2v0mA-3k9bA:25.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3krt | CROTONYL COAREDUCTASE (Streptomycescoelicolor) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ARG A 445LEU A 218ILE A 388ALA A 251ARG A 270 | None | 1.42A | 2v0mA-3krtA:undetectable | 2v0mA-3krtA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ksc | LEGA CLASS (Pisum sativum) |
PF00190(Cupin_1) | 5 | SER A 142ILE A 70PHE A 114GLU A 32LEU A 53 | None | 1.22A | 2v0mA-3kscA:undetectable | 2v0mA-3kscA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mem | PUTATIVE SIGNALTRANSDUCTION PROTEIN (Marinobacterhydrocarbonoclasticus) |
PF04073(tRNA_edit)PF08668(HDOD) | 5 | ARG A 441LEU A 395ALA A 286GLU A 437LEU A 403 | None | 1.32A | 2v0mA-3memA:undetectable | 2v0mA-3memA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o4z | TELOMERE LENGTHREGULATION PROTEINTEL2 (Saccharomycescerevisiae) |
PF10193(Telomere_reg-2) | 5 | LEU A 538ILE A 510ALA A 506GLU A 445LEU A 490 | None | 1.22A | 2v0mA-3o4zA:undetectable | 2v0mA-3o4zA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o7q | L-FUCOSE-PROTONSYMPORTER (Escherichiacoli) |
PF07690(MFS_1) | 5 | LEU A 145ILE A 25PHE A 28ALA A 29LEU A 157 | None | 1.35A | 2v0mA-3o7qA:undetectable | 2v0mA-3o7qA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3opb | SWI5-DEPENDENT HOEXPRESSION PROTEIN 4 (Saccharomycescerevisiae) |
PF11701(UNC45-central) | 5 | LEU A 714PHE A 701ALA A 702GLU A 739LEU A 747 | None | 1.41A | 2v0mA-3opbA:undetectable | 2v0mA-3opbA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3peh | ENDOPLASMIN HOMOLOG (Plasmodiumfalciparum) |
PF00183(HSP90)PF02518(HATPase_c) | 5 | LEU A 100ILE A 243PHE A 99ALA A 197LEU A 247 | None | 1.39A | 2v0mA-3pehA:undetectable | 2v0mA-3pehA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pnz | PHOSPHOTRIESTERASEFAMILY PROTEIN (Listeriamonocytogenes) |
PF02126(PTE) | 5 | SER A 186LEU A 195ILE A 213ALA A 233ARG A 175 | None | 1.08A | 2v0mA-3pnzA:undetectable | 2v0mA-3pnzA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q6d | PROLINE DIPEPTIDASE (Bacillusanthracis) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 5 | PHE A 11ILE A 76ALA A 109GLU A 94LEU A 91 | None | 1.39A | 2v0mA-3q6dA:1.5 | 2v0mA-3q6dA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rk6 | POLYADENYLATE-BINDINGPROTEIN-INTERACTINGPROTEIN 1 (Homo sapiens) |
PF02854(MIF4G) | 5 | ILE A 101PHE A 104ALA A 105ARG A 166LEU A 121 | None | 1.32A | 2v0mA-3rk6A:undetectable | 2v0mA-3rk6A:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT JNADH-QUINONEOXIDOREDUCTASESUBUNIT KNADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli) |
no annotation | 5 | PHE J 67SER N 136LEU N 171ALA N 166LEU K 35 | None | 1.37A | 2v0mA-3rkoJ:undetectable | 2v0mA-3rkoJ:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u92 | GLUTAMATE RECEPTOR,IONOTROPIC KAINATE 3 (Rattusnorvegicus) |
PF10613(Lig_chan-Glu_bd) | 5 | SER A 102LEU A 40ILE A 229ALA A 232LEU A 242 | None | 1.10A | 2v0mA-3u92A:undetectable | 2v0mA-3u92A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ulz | BRASSINOSTEROIDINSENSITIVE1-ASSOCIATEDRECEPTOR KINASE 1 (Arabidopsisthaliana) |
PF00069(Pkinase) | 5 | SER A 397LEU A 385ILE A 422GLU A 564LEU A 538 | None | 1.44A | 2v0mA-3ulzA:undetectable | 2v0mA-3ulzA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v4g | ARGININE REPRESSOR (Vibriovulnificus) |
PF01316(Arg_repressor)PF02863(Arg_repressor_C) | 5 | LEU A 95ILE A 131PHE A 132ALA A 126ARG A 48 | None | 1.43A | 2v0mA-3v4gA:undetectable | 2v0mA-3v4gA:17.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wks | O-PHOSPHO-L-SERYL-TRNA:CYS-TRNA SYNTHASE (Methanocaldococcusjannaschii) |
PF05889(SepSecS) | 5 | ARG A 135LEU A 206ILE A 107ALA A 111LEU A 138 | None | 1.21A | 2v0mA-3wksA:undetectable | 2v0mA-3wksA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4asy | GLUCOSE-1-PHOSPHATETHYMIDYLYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00483(NTP_transferase) | 5 | ARG A 128SER A 124LEU A 45PHE A 118LEU A 175 | NoneNoneN5Y A1294 (-3.7A)NoneNone | 1.29A | 2v0mA-4asyA:undetectable | 2v0mA-4asyA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bhh | NUCLEOPROTEIN (Californiaencephalitisorthobunyavirus) |
PF00952(Bunya_nucleocap) | 5 | PHE B 152SER B 33ALA B 38ARG B 101LEU B 99 | None | 1.31A | 2v0mA-4bhhB:undetectable | 2v0mA-4bhhB:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c7p | RALF (Legionellapneumophila) |
PF01369(Sec7) | 5 | LEU A 53ILE A 27ARG A 109GLU A 66LEU A 62 | None | 1.12A | 2v0mA-4c7pA:undetectable | 2v0mA-4c7pA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dng | UNCHARACTERIZEDALDEHYDEDEHYDROGENASE ALDY (Bacillussubtilis) |
PF00171(Aldedh) | 5 | PHE A 383SER A 430ILE A 428ALA A 402GLU A 253 | None | 1.24A | 2v0mA-4dngA:0.3 | 2v0mA-4dngA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e1e | FARNESYLPYROPHOSPHATESYNTHASE (Trypanosomacruzi) |
PF00348(polyprenyl_synt) | 5 | LEU A 234ILE A 336ALA A 347ARG A 51LEU A 217 | NoneNoneNoneIPE A 405 (-2.5A)None | 1.20A | 2v0mA-4e1eA:undetectable | 2v0mA-4e1eA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fbh | PROTEIN SYNTHESISINHIBITOR I (Hordeum vulgare) |
PF00161(RIP) | 5 | SER A 45PHE A 236ALA A 247ARG A 178LEU A 216 | NoneNoneNoneAMP A 301 (-3.0A)None | 1.26A | 2v0mA-4fbhA:undetectable | 2v0mA-4fbhA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gwn | MEPRIN A SUBUNITBETA (Homo sapiens) |
PF00629(MAM)PF01400(Astacin) | 5 | LEU A 448ILE A 441ALA A 473ARG A 511LEU A 501 | None | 1.28A | 2v0mA-4gwnA:undetectable | 2v0mA-4gwnA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jmk | DUAL SPECIFICITYPROTEIN PHOSPHATASE8 (Homo sapiens) |
PF00782(DSPc) | 5 | SER A 228LEU A 170ILE A 256ALA A 193ARG A 207 | None | 1.40A | 2v0mA-4jmkA:undetectable | 2v0mA-4jmkA:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nfn | TAU-TUBULIN KINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 5 | SER A 224PHE A 199ALA A 210ARG A 240GLU A 231 | NoneNoneNoneSO4 A 403 (-4.1A)SO4 A 403 ( 4.9A) | 1.36A | 2v0mA-4nfnA:undetectable | 2v0mA-4nfnA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nnb | OBCA, OXALATEBIOSYNTHETICCOMPONENT A (Burkholderiaglumae) |
PF05853(BKACE) | 5 | LEU A 455ILE A 397ALA A 377GLU A 433LEU A 465 | None | 1.27A | 2v0mA-4nnbA:undetectable | 2v0mA-4nnbA:22.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ny4 | CYTOCHROME P450 3A4 (Homo sapiens) |
PF00067(p450) | 6 | ARG A 105SER A 119LEU A 210ILE A 301ALA A 305MET A 371 | HEM A 601 ( 2.8A)2QH A 602 (-3.9A)NoneNone2QH A 602 ( 3.6A)None | 1.03A | 2v0mA-4ny4A:53.2 | 2v0mA-4ny4A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ny4 | CYTOCHROME P450 3A4 (Homo sapiens) |
PF00067(p450) | 7 | PHE A 57ARG A 105SER A 119ILE A 301ALA A 305MET A 371ARG A 372 | NoneHEM A 601 ( 2.8A)2QH A 602 (-3.9A)None2QH A 602 ( 3.6A)NoneNone | 0.55A | 2v0mA-4ny4A:53.2 | 2v0mA-4ny4A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ny4 | CYTOCHROME P450 3A4 (Homo sapiens) |
PF00067(p450) | 6 | PHE A 57ARG A 105SER A 119ILE A 301PHE A 304ALA A 305 | NoneHEM A 601 ( 2.8A)2QH A 602 (-3.9A)None2QH A 602 (-3.3A)2QH A 602 ( 3.6A) | 1.19A | 2v0mA-4ny4A:53.2 | 2v0mA-4ny4A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ny4 | CYTOCHROME P450 3A4 (Homo sapiens) |
PF00067(p450) | 5 | SER A 119ILE A 301ALA A 305MET A 371GLU A 374 | 2QH A 602 (-3.9A)None2QH A 602 ( 3.6A)None2QH A 602 ( 4.8A) | 0.74A | 2v0mA-4ny4A:53.2 | 2v0mA-4ny4A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ny4 | CYTOCHROME P450 3A4 (Homo sapiens) |
PF00067(p450) | 5 | SER A 119ILE A 301PHE A 304ALA A 305GLU A 374 | 2QH A 602 (-3.9A)None2QH A 602 (-3.3A)2QH A 602 ( 3.6A)2QH A 602 ( 4.8A) | 1.22A | 2v0mA-4ny4A:53.2 | 2v0mA-4ny4A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oec | GLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE (Thermococcuskodakarensis) |
PF03009(GDPD) | 5 | PHE A 27LEU A 44ALA A 117GLU A 39LEU A 90 | NoneNoneNone MG A 401 (-2.6A)None | 1.43A | 2v0mA-4oecA:undetectable | 2v0mA-4oecA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p0f | SERINE PROTEASEINHIBITOR 4, ISOFORMB (Drosophilamelanogaster) |
PF00079(Serpin) | 5 | PHE A 359SER A 36LEU A 229ILE A 168PHE A 170 | None | 1.41A | 2v0mA-4p0fA:undetectable | 2v0mA-4p0fA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p0f | SERINE PROTEASEINHIBITOR 4, ISOFORMB (Drosophilamelanogaster) |
PF00079(Serpin) | 5 | SER A 36LEU A 229ILE A 168PHE A 170ALA A 330 | None | 1.41A | 2v0mA-4p0fA:undetectable | 2v0mA-4p0fA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pwu | MODULATOR PROTEINMZRA (Klebsiellapneumoniae) |
PF13721(SecD-TM1) | 5 | LEU A 94ILE A 65ALA A 89GLU A 36LEU A 106 | None | 0.99A | 2v0mA-4pwuA:undetectable | 2v0mA-4pwuA:11.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4up7 | LYSINE--TRNA LIGASE (Entamoebahistolytica) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 5 | PHE A 191LEU A 230ILE A 523ALA A 522ARG A 242 | None | 1.44A | 2v0mA-4up7A:undetectable | 2v0mA-4up7A:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wgx | MOLINATE HYDROLASE (Gulosibactermolinativorax) |
PF01979(Amidohydro_1) | 5 | LEU A 70ILE A 137ALA A 99GLU A 296LEU A 366 | None | 1.42A | 2v0mA-4wgxA:undetectable | 2v0mA-4wgxA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ydj | HEAVY CHAIN OFANTIBODY 44-VRC13.01LIGHT CHAIN OFANTIBODY 44-VRC13.01 (Homo sapiens) |
no annotation | 5 | ILE H 35ALA H 93ARG L 53GLU H 100LEU L 46 | None | 1.27A | 2v0mA-4ydjH:undetectable | 2v0mA-4ydjH:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z64 | PHYTOSULFOKINERECEPTOR 1 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13855(LRR_8) | 5 | PHE A 121LEU A 88ILE A 43GLU A 94LEU A 105 | None | 1.39A | 2v0mA-4z64A:undetectable | 2v0mA-4z64A:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zdn | AT-LESS POLYKETIDESYNTHASE (Streptomycesplatensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | ILE A 909ALA A 906ARG A 624GLU A 649LEU A 619 | None | 1.41A | 2v0mA-4zdnA:undetectable | 2v0mA-4zdnA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zuz | SIDC (Legionellapneumophila) |
no annotation | 5 | ARG A 797LEU A 780PHE A 777ALA A 773GLU A 795 | None | 1.36A | 2v0mA-4zuzA:2.6 | 2v0mA-4zuzA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zuz | SIDC (Legionellapneumophila) |
no annotation | 5 | LEU A 368ILE A 408ALA A 359GLU A 375LEU A 178 | None | 1.28A | 2v0mA-4zuzA:2.6 | 2v0mA-4zuzA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aa6 | VANADIUM-DEPENDENTBROMOPEROXIDASE 2 (Ascophyllumnodosum) |
no annotation | 5 | PHE A 491SER A 524LEU A 231ILE A 528GLU A 518 | None | 1.21A | 2v0mA-5aa6A:undetectable | 2v0mA-5aa6A:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cws | NUCLEOPORIN NSP1NUCLEOPORIN NUP57 (Chaetomiumthermophilum) |
PF05064(Nsp1_C)PF13874(Nup54) | 5 | ARG E 197LEU C 548ALA E 203ARG E 191LEU C 541 | None | 1.42A | 2v0mA-5cwsE:undetectable | 2v0mA-5cwsE:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dan | 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE (Thermotogamaritima) |
PF00248(Aldo_ket_red) | 5 | ILE A 260ALA A 231ARG A 247GLU A 249LEU A 201 | NoneNoneNAP A 301 (-4.1A)NoneNAP A 301 (-4.0A) | 1.27A | 2v0mA-5danA:undetectable | 2v0mA-5danA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f2o | FATTY ACIDO-METHYLTRANSFERASE (Mycobacteriummarinum) |
PF03492(Methyltransf_7) | 5 | SER A 149LEU A 264ILE A 153ALA A 154LEU A 359 | NoneNoneNone5UF A 401 ( 4.9A)None | 1.44A | 2v0mA-5f2oA:undetectable | 2v0mA-5f2oA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fv4 | CARBOXYLIC ESTERHYDROLASE (Sus scrofa) |
PF00135(COesterase) | 5 | LEU A 100ILE A 151ALA A 132GLU A 208LEU A 155 | None | 1.38A | 2v0mA-5fv4A:undetectable | 2v0mA-5fv4A:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gqq | HEME-BINDING PROTEIN2 (Homo sapiens) |
PF04832(SOUL) | 5 | LEU A 69ILE A 62PHE A 66GLU A 191LEU A 185 | None | 1.09A | 2v0mA-5gqqA:undetectable | 2v0mA-5gqqA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ica | PERIODIC TRYPTOPHANPROTEIN 2-LIKEPROTEIN (Chaetomiumthermophilum) |
PF04003(Utp12) | 5 | PHE D 738LEU D 791ALA D 820ARG D 772LEU D 774 | None | 1.44A | 2v0mA-5icaD:undetectable | 2v0mA-5icaD:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ig1 | CAMK/CAMK2 PROTEINKINASE (Salpingoecarosetta) |
PF00069(Pkinase) | 5 | PHE A 296LEU A 125ALA A 119GLU A 101LEU A 210 | None | 1.30A | 2v0mA-5ig1A:undetectable | 2v0mA-5ig1A:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikz | OXALATE BIOSYNTHETICCOMPONENT 1 (Burkholderiathailandensis) |
PF05853(BKACE) | 5 | LEU A 459ILE A 401ALA A 381GLU A 437LEU A 469 | None | 1.25A | 2v0mA-5ikzA:undetectable | 2v0mA-5ikzA:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jr9 | NEQ131 (Nanoarchaeumequitans) |
PF01997(Translin) | 5 | LEU B 148ILE B 172MET B 40GLU B 129LEU B 89 | None | 1.35A | 2v0mA-5jr9B:undetectable | 2v0mA-5jr9B:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lfd | ALLANTOIN RACEMASE (Pseudomonasfluorescens) |
no annotation | 5 | ILE A 18ALA A 184MET A 144GLU A 45LEU A 149 | None | 1.24A | 2v0mA-5lfdA:undetectable | 2v0mA-5lfdA:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5me3 | SISTER CHROMATIDCOHESION PROTEIN 2 (Eremotheciumgossypii) |
PF12765(Cohesin_HEAT)PF12830(Nipped-B_C) | 5 | SER A 437LEU A 517ILE A 433ARG A 529LEU A 527 | None | 1.38A | 2v0mA-5me3A:0.0 | 2v0mA-5me3A:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mpm | SARCOPLASMIC/ENDOPLASMIC RETICULUMCALCIUM ATPASE 2 (Sus scrofa) |
no annotation | 5 | LEU A 356ILE A 348ARG A 334GLU A 731LEU A 734 | NoneNoneNone K A1005 (-2.9A)None | 1.33A | 2v0mA-5mpmA:undetectable | 2v0mA-5mpmA:10.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mpm | SARCOPLASMIC/ENDOPLASMIC RETICULUMCALCIUM ATPASE 2 (Sus scrofa) |
no annotation | 5 | LEU A 356PHE A 739ARG A 334GLU A 731LEU A 734 | NoneNoneNone K A1005 (-2.9A)None | 1.44A | 2v0mA-5mpmA:undetectable | 2v0mA-5mpmA:10.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n6v | AMYLOSUCRASE (Neisseriapolysaccharea) |
no annotation | 5 | PHE A 312ARG A 75ILE A 169ALA A 179LEU A 283 | None | 1.26A | 2v0mA-5n6vA:undetectable | 2v0mA-5n6vA:10.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n6v | AMYLOSUCRASE (Neisseriapolysaccharea) |
no annotation | 5 | PHE A 312LEU A 135ILE A 169ALA A 179LEU A 283 | None | 1.23A | 2v0mA-5n6vA:undetectable | 2v0mA-5n6vA:10.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nva | PUTATIVESODIUM:SOLUTESYMPORTER (Proteusmirabilis) |
no annotation | 5 | PHE A 131SER A 468LEU A 456ALA A 449LEU A 413 | None | 1.33A | 2v0mA-5nvaA:0.0 | 2v0mA-5nvaA:11.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t8v | PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
PF12765(Cohesin_HEAT)PF12830(Nipped-B_C) | 5 | SER A1333LEU A1313ILE A1363ALA A1367LEU A1373 | None | 1.28A | 2v0mA-5t8vA:0.0 | 2v0mA-5t8vA:16.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5veu | CYTOCHROME P450 3A5 (Homo sapiens) |
no annotation | 6 | ARG A 105SER A 119ILE A 301ALA A 305GLU A 374LEU A 481 | HEM A 601 (-2.8A)RIT A 602 (-3.7A)RIT A 602 ( 4.9A)HEM A 601 (-3.4A)RIT A 602 ( 4.8A)None | 0.67A | 2v0mA-5veuA:56.5 | 2v0mA-5veuA:83.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5veu | CYTOCHROME P450 3A5 (Homo sapiens) |
no annotation | 6 | ARG A 105SER A 119ILE A 301PHE A 304ALA A 305LEU A 481 | HEM A 601 (-2.8A)RIT A 602 (-3.7A)RIT A 602 ( 4.9A)RIT A 602 (-3.7A)HEM A 601 (-3.4A)None | 0.73A | 2v0mA-5veuA:56.5 | 2v0mA-5veuA:83.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5veu | CYTOCHROME P450 3A5 (Homo sapiens) |
no annotation | 6 | PHE A 215ARG A 105ILE A 301PHE A 304ALA A 305LEU A 481 | RIT A 602 (-4.0A)HEM A 601 (-2.8A)RIT A 602 ( 4.9A)RIT A 602 (-3.7A)HEM A 601 (-3.4A)None | 1.49A | 2v0mA-5veuA:56.5 | 2v0mA-5veuA:83.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5veu | CYTOCHROME P450 3A5 (Homo sapiens) |
no annotation | 6 | SER A 119ILE A 301PHE A 304ALA A 305ARG A 372LEU A 481 | RIT A 602 (-3.7A)RIT A 602 ( 4.9A)RIT A 602 (-3.7A)HEM A 601 (-3.4A)NoneNone | 0.97A | 2v0mA-5veuA:56.5 | 2v0mA-5veuA:83.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6aoj | CEG4 (Legionellapneumophila) |
no annotation | 5 | SER A 81LEU A 196PHE A 87ARG A 184LEU A 156 | None | 1.33A | 2v0mA-6aojA:undetectable | 2v0mA-6aojA:10.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ces | RAS-RELATEDGTP-BINDING PROTEINC (Homo sapiens) |
no annotation | 5 | PHE C 134ILE C 195ALA C 199MET C 171GLU C 174 | None | 1.18A | 2v0mA-6cesC:undetectable | 2v0mA-6cesC:9.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cxd | PEPTIDASE B (Yersinia pestis) |
no annotation | 5 | LEU A 244ILE A 301ALA A 191GLU A 339LEU A 238 | NoneNoneNoneSO4 A 501 (-2.7A)None | 1.19A | 2v0mA-6cxdA:undetectable | 2v0mA-6cxdA:10.82 |