SIMILAR PATTERNS OF AMINO ACIDS FOR 2V0G_D_LEUD1883

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		4 TYR A  38
ASP A  35
TYR A 170
TYR A 146
 None
 1.37A 2v0gD-1eg1A:
undetectable		 2v0gD-1eg1A:
15.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		4 TYR A  43
ASP A  80
TYR A 507
TYR A 535
 NVA  A1816 ( 3.5A)
NVA  A1816 (-3.9A)
None
None
 0.34A 2v0gD-1obhA:
37.2		 2v0gD-1obhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg7 HUMANIZED ANTIBODY
D3H44
MURINE ANTIBODY 6A6
FAB FRAGMENT

(Homo sapiens;
Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  33
ASP H  52
TYR X 102
HIS X  32
 None
 1.42A 2v0gD-1pg7H:
undetectable		 2v0gD-1pg7H:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC

(Escherichia
coli) 		PF03009
(GDPD) 		4 TYR A 238
ASP A 280
TYR A 281
TYR A 323
 None
 1.30A 2v0gD-1t8qA:
1.2		 2v0gD-1t8qA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		4 TYR A  58
ASP A 286
TYR A 380
HIS A 384
 None
 1.40A 2v0gD-1tz7A:
0.0		 2v0gD-1tz7A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6x CITRATE SYNTHASE 1

(Bacillus
subtilis) 		PF00285
(Citrate_synt) 		4 TYR A 255
ASP A 259
TYR A  28
HIS A 178
 None
None
None
CIT  A1366 (-3.0A)
 1.47A 2v0gD-2c6xA:
0.0		 2v0gD-2c6xA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2el7 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		4 TYR A  44
ASP A  43
TYR A 140
HIS A  90
 None
 1.45A 2v0gD-2el7A:
6.8		 2v0gD-2el7A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja2 GLUTAMYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00749
(tRNA-synt_1c) 		4 ASP A 133
TYR A 132
TYR A 108
HIS A 138
 None
 1.23A 2v0gD-2ja2A:
13.5		 2v0gD-2ja2A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE

(Pyrococcus
abyssi) 		PF00144
(Beta-lactamase)
PF13969
(Pab87_oct) 		4 TYR A 284
TYR A 291
TYR A 312
HIS A 302
 None
 1.24A 2v0gD-2qmiA:
undetectable		 2v0gD-2qmiA:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 TYR A  46
ASP A  84
TYR A 327
TYR A 361
HIS A 367
 LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-4.8A)
None
LSS  A1638 (-3.8A)
 0.40A 2v0gD-3ziuA:
43.7		 2v0gD-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 TYR A  43
ASP A  80
TYR A 499
TYR A 527
HIS A 533
 LEU  A1001 (-3.5A)
LEU  A1001 (-3.9A)
None
None
LEU  A1001 (-4.2A)
 0.57A 2v0gD-4arcA:
34.1		 2v0gD-4arcA:
45.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		4 TYR A 764
ASP A 456
TYR A 533
TYR A 528
 None
 1.49A 2v0gD-4areA:
3.4		 2v0gD-4areA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Bacillus
anthracis) 		PF00144
(Beta-lactamase) 		4 TYR A 196
TYR A 209
TYR A 372
HIS A 198
 None
 1.49A 2v0gD-4gb7A:
undetectable		 2v0gD-4gb7A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kia LMO2213 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 TYR A 157
ASP A 155
TYR A  72
TYR A  53
 None
 1.12A 2v0gD-4kiaA:
undetectable		 2v0gD-4kiaA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2b ENDO-1,4-BETA-D-GLUC
ANASE

(Pseudomonas
putida) 		PF01270
(Glyco_hydro_8) 		4 TYR A 182
ASP A 116
TYR A  59
TYR A 335
 None
TRS  A 402 (-2.8A)
None
None
 1.48A 2v0gD-4q2bA:
2.8		 2v0gD-4q2bA:
17.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 TYR A  41
ASP A  78
TYR A 496
TYR A 523
HIS A 529
 LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-4.0A)
 0.36A 2v0gD-5ah5A:
46.1		 2v0gD-5ah5A:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd2 ENDO-1,4-D-GLUCANASE

(Aliivibrio
fischeri) 		PF01270
(Glyco_hydro_8) 		4 TYR A 203
ASP A 136
TYR A  79
TYR A 359
 None
GOL  A 402 (-2.9A)
None
None
 1.30A 2v0gD-5cd2A:
2.1		 2v0gD-5cd2A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 TYR A 299
TYR A 399
TYR A 374
HIS A 270
 None
None
None
FAD  A 901 (-4.8A)
 1.05A 2v0gD-5l46A:
undetectable		 2v0gD-5l46A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER

(Prochlorococcus
marinus) 		no annotation 4 TYR A 206
ASP A 205
TYR A 203
HIS A 158
 GB  A 401 (-3.2A)
GB  A 401 (-2.7A)
None
GB  A 401 (-4.0A)
 1.21A 2v0gD-5lq8A:
undetectable		 2v0gD-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7e COLH PROTEIN

(Hathewaya
histolytica) 		no annotation 4 TYR A 695
ASP A 388
TYR A 465
TYR A 460
 None
 1.47A 2v0gD-5o7eA:
undetectable		 2v0gD-5o7eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum) 		no annotation 4 TYR A  38
ASP A  35
TYR A 170
TYR A 146
 TYR  A  38 ( 1.3A)
ASP  A  35 ( 0.6A)
TYR  A 170 ( 1.3A)
TYR  A 146 ( 1.3A)
 1.38A 2v0gD-5w0aA:
undetectable		 2v0gD-5w0aA:
undetectable