SIMILAR PATTERNS OF AMINO ACIDS FOR 2V0G_A_LEUA1887_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		4 TYR A 154
ASP A 168
SER A 133
TYR A 160
 None
 1.29A 2v0gA-1bxkA:
1.5		 2v0gA-1bxkA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e33 ARYLSULFATASE A

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		4 SER P 225
TYR P 201
HIS P 151
HIS P 226
 None
 1.03A 2v0gA-1e33P:
undetectable		 2v0gA-1e33P:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 TYR A  35
ASP A  17
SER A  20
HIS A  24
 None
None
None
OXY  A 405 ( 4.8A)
 1.23A 2v0gA-1e5dA:
undetectable		 2v0gA-1e5dA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		4 TYR A  38
ASP A  35
TYR A 170
TYR A 146
 None
 1.32A 2v0gA-1eg1A:
undetectable		 2v0gA-1eg1A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		4 TYR A 161
ASP A 175
SER A 132
TYR A 167
 None
 1.35A 2v0gA-1g1aA:
1.3		 2v0gA-1g1aA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		4 ASP A 153
SER A 182
TYR A 185
HIS A 146
 None
None
None
ZN  A 401 ( 3.2A)
 1.15A 2v0gA-1htdA:
undetectable		 2v0gA-1htdA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		4 ASP A 155
SER A 183
TYR A 186
HIS A 144
 None
None
None
CD  A 981 (-3.5A)
 1.37A 2v0gA-1kugA:
0.7		 2v0gA-1kugA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 SER A 252
TYR A  92
TYR A 192
HIS A 253
 None
FE  A 693 ( 4.2A)
CO3  A 695 ( 4.0A)
FE  A 693 ( 3.3A)
 1.30A 2v0gA-1n76A:
undetectable		 2v0gA-1n76A:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		6 MET A  40
ASP A  80
SER A 504
TYR A 507
TYR A 535
HIS A 545
 LMS  A1817 ( 3.7A)
NVA  A1816 (-3.9A)
NVA  A1816 ( 4.8A)
None
None
NVA  A1816 (-3.5A)
 0.61A 2v0gA-1obhA:
51.8		 2v0gA-1obhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		6 MET A  40
TYR A  43
ASP A  80
TYR A 507
TYR A 535
HIS A 545
 LMS  A1817 ( 3.7A)
NVA  A1816 ( 3.5A)
NVA  A1816 (-3.9A)
None
None
NVA  A1816 (-3.5A)
 0.41A 2v0gA-1obhA:
51.8		 2v0gA-1obhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvj PYROGENIC EXOTOXIN B

(Streptococcus
pyogenes) 		PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69) 		4 MET A 274
SER A 271
TYR A 216
TYR A 276
 None
 1.24A 2v0gA-1pvjA:
undetectable		 2v0gA-1pvjA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)

(Homo sapiens) 		PF00092
(VWA) 		4 MET B 411
ASP B 340
SER B 342
HIS B 447
 None
MG  B 602 ( 4.5A)
MG  B 602 (-2.1A)
None
 1.32A 2v0gA-1qc5B:
undetectable		 2v0gA-1qc5B:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snz ALDOSE 1-EPIMERASE

(Homo sapiens) 		PF01263
(Aldose_epim) 		4 TYR A 281
ASP A 243
HIS A 176
HIS A 107
 None
 1.13A 2v0gA-1snzA:
undetectable		 2v0gA-1snzA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tfd TRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		4 SER A 248
TYR A  95
TYR A 188
HIS A 249
 None
FE  A 950 ( 4.3A)
CO3  A 900 ( 3.6A)
FE  A 950 ( 3.4A)
 1.20A 2v0gA-1tfdA:
undetectable		 2v0gA-1tfdA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfd LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 SER A 252
TYR A  92
TYR A 192
HIS A 253
 None
FE  A 400 (-4.1A)
CO3  A 401 (-3.8A)
FE  A 400 (-3.1A)
 1.29A 2v0gA-1vfdA:
undetectable		 2v0gA-1vfdA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		4 MET A  82
TYR A  90
TYR A  93
HIS A 329
 None
 1.21A 2v0gA-1wzaA:
undetectable		 2v0gA-1wzaA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		4 ASP A 963
SER A1002
TYR A 994
TYR A  28
 MG  A2237 ( 2.6A)
None
TPP  A2236 (-4.5A)
None
 1.36A 2v0gA-2c3oA:
undetectable		 2v0gA-2c3oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		4 TYR A 608
ASP A 600
TYR A 692
HIS A 649
 None
 1.26A 2v0gA-2cn3A:
undetectable		 2v0gA-2cn3A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7j SEP-TRNA:CYS-TRNA
SYNTHASE

(Archaeoglobus
fulgidus) 		PF05889
(SepSecS) 		4 ASP A 157
TYR A 186
HIS A 298
HIS A 300
 None
PLP  A1209 (-4.2A)
None
None
 1.39A 2v0gA-2e7jA:
undetectable		 2v0gA-2e7jA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exh BETA-D-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43) 		4 ASP A 479
SER A 477
TYR A 462
TYR A 529
 None
 1.39A 2v0gA-2exhA:
undetectable		 2v0gA-2exhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		4 MET A 260
ASP A 257
TYR A 223
HIS A 214
 None
ZN  A1000 (-2.2A)
None
ZN  A1001 (-3.2A)
 1.21A 2v0gA-2gsnA:
undetectable		 2v0gA-2gsnA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
T-CELL RECEPTOR BETA
CHAIN V

(Mycoplasma
arthritidis;
Mus musculus) 		PF09245
(MA-Mit)
PF07686
(V-set) 		4 TYR J  33
TYR J 100
TYR G 188
HIS J  29
 None
 1.26A 2v0gA-2icwJ:
undetectable		 2v0gA-2icwJ:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2il5 HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF08327
(AHSA1) 		4 MET A  89
TYR A 121
ASP A 101
TYR A  60
 None
 1.35A 2v0gA-2il5A:
undetectable		 2v0gA-2il5A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 MET A 138
SER A 287
TYR A 290
TYR A  81
 None
 1.30A 2v0gA-2j3hA:
undetectable		 2v0gA-2j3hA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzd REPLICASE
POLYPROTEIN 1AB

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11633
(SUD-M) 		4 ASP A 552
SER A 585
TYR A 583
HIS A 613
 None
 1.02A 2v0gA-2jzdA:
undetectable		 2v0gA-2jzdA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqh PUTATIVE ISOMERASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 197
TYR A 221
HIS A 297
HIS A 268
 None
 1.30A 2v0gA-2oqhA:
undetectable		 2v0gA-2oqhA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE

(Pyrococcus
abyssi) 		PF00144
(Beta-lactamase)
PF13969
(Pab87_oct) 		4 TYR A 284
TYR A 291
TYR A 312
HIS A 302
 None
 1.34A 2v0gA-2qmiA:
undetectable		 2v0gA-2qmiA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r26 CITRATE SYNTHASE

(Thermoplasma
acidophilum) 		PF00285
(Citrate_synt) 		4 MET A 177
TYR A 156
ASP A  47
TYR A 324
 None
 1.14A 2v0gA-2r26A:
undetectable		 2v0gA-2r26A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Paraburkholderia
phymatum) 		PF13377
(Peripla_BP_3) 		4 ASP A 275
SER A 316
TYR A 301
HIS A 318
 None
 1.37A 2v0gA-2rgyA:
undetectable		 2v0gA-2rgyA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rij PUTATIVE
2,3,4,5-TETRAHYDROPY
RIDINE-2-CARBOXYLATE
N-
SUCCINYLTRANSFERASE

(Campylobacter
jejuni) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M)
PF14790
(THDPS_N) 		4 ASP A  33
SER A  46
TYR A 141
HIS A 210
 None
 1.20A 2v0gA-2rijA:
undetectable		 2v0gA-2rijA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Schistosoma
mansoni) 		PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 MET A 328
SER A 485
TYR A 479
HIS A 538
 None
 1.29A 2v0gA-2v6oA:
undetectable		 2v0gA-2v6oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2g NON-STRUCTURAL
PROTEIN 3

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11633
(SUD-M) 		4 ASP A 552
SER A 585
TYR A 583
HIS A 613
 None
 1.21A 2v0gA-2w2gA:
undetectable		 2v0gA-2w2gA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 MET A 357
SER A 393
TYR A 355
HIS A 395
 None
None
FAD  A 601 (-4.3A)
None
 1.33A 2v0gA-2wu5A:
undetectable		 2v0gA-2wu5A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybr SINGLE CHAIN
ANTIBODY FRAGMENT
9004G
BETA-MAMMAL TOXIN
CN2

(Homo sapiens;
Centruroides
noxius) 		PF07686
(V-set)
PF00537
(Toxin_3) 		4 ASP B 182
SER B 163
TYR B 164
TYR C  42
 None
 1.39A 2v0gA-2ybrB:
undetectable		 2v0gA-2ybrB:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4v FOLLISTATIN-LIKE 3

(Homo sapiens) 		PF07648
(Kazal_2)
PF09289
(FOLN) 		4 MET C 136
ASP C 112
TYR C 137
HIS C 165
 None
 1.36A 2v0gA-3b4vC:
undetectable		 2v0gA-3b4vC:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 MET A1012
ASP A 613
TYR A 651
TYR A 654
 None
 1.31A 2v0gA-3bg9A:
0.9		 2v0gA-3bg9A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI

(Pseudomonas
putida) 		PF10778
(DehI) 		4 ASP A 189
TYR A 217
HIS A 183
HIS A 181
 SO4  A 297 (-3.7A)
None
None
None
 1.38A 2v0gA-3bjxA:
undetectable		 2v0gA-3bjxA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2u XYLOSIDASE/ARABINOSI
DASE

(Selenomonas
ruminantium) 		PF04616
(Glyco_hydro_43)
PF07081
(DUF1349) 		4 TYR A 139
ASP A 133
TYR A 224
HIS A 221
 None
 1.32A 2v0gA-3c2uA:
undetectable		 2v0gA-3c2uA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)

(Streptococcus
pneumoniae) 		PF12850
(Metallophos_2) 		4 TYR A  64
ASP A  59
SER A  39
HIS A  35
 None
 0.91A 2v0gA-3ck2A:
undetectable		 2v0gA-3ck2A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d62 3C-LIKE PROTEINASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF05409
(Peptidase_C30) 		4 SER A 144
TYR A 161
HIS A 172
HIS A 163
 959  A 350 ( 4.4A)
None
None
None
 1.39A 2v0gA-3d62A:
undetectable		 2v0gA-3d62A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dgz THIOREDOXIN
REDUCTASE 2

(Mus musculus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 MET A 227
SER A 378
TYR A 372
HIS A 431
 None
 1.23A 2v0gA-3dgzA:
undetectable		 2v0gA-3dgzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh9 THIOREDOXIN
REDUCTASE 1

(Drosophila
melanogaster) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 MET A 229
SER A 378
TYR A 372
HIS A 431
 None
 1.23A 2v0gA-3dh9A:
undetectable		 2v0gA-3dh9A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn9 PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 SER A 590
TYR A 594
TYR A 504
HIS A 537
 None
 1.38A 2v0gA-3fn9A:
undetectable		 2v0gA-3fn9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		4 ASP A 255
SER A 254
TYR A 297
HIS A 239
 None
None
None
MLA  A 302 ( 3.5A)
 1.28A 2v0gA-3fssA:
undetectable		 2v0gA-3fssA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		4 ASP A 352
SER A 348
TYR A 177
HIS A 123
 None
 1.24A 2v0gA-3g8mA:
undetectable		 2v0gA-3g8mA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Giardia
intestinalis) 		PF01116
(F_bP_aldolase) 		4 MET A   9
SER A 303
TYR A  18
TYR A 310
 None
 1.34A 2v0gA-3gayA:
undetectable		 2v0gA-3gayA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs9 PROTEIN GP18

(Listeria
monocytogenes) 		PF06605
(Prophage_tail) 		4 TYR A 266
ASP A 265
SER A 230
TYR A 228
 None
None
None
MLY  A 260 ( 3.9A)
 1.29A 2v0gA-3gs9A:
undetectable		 2v0gA-3gs9A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 TYR A  94
TYR A  36
HIS A  53
HIS A 108
 None
 1.24A 2v0gA-3h3zA:
undetectable		 2v0gA-3h3zA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		4 TYR A 145
SER A 104
TYR A 121
HIS A 142
 None
AAE  A 501 (-2.5A)
None
None
 1.29A 2v0gA-3i09A:
undetectable		 2v0gA-3i09A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE

(Homo sapiens) 		PF01242
(PTPS) 		4 ASP A  94
SER A 105
TYR A  53
HIS A  49
 None
None
None
NI  A 146 (-3.1A)
 1.21A 2v0gA-3i2bA:
undetectable		 2v0gA-3i2bA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Leishmania
mexicana) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ASP B 318
SER B 370
TYR B 363
TYR B 210
 None
 1.38A 2v0gA-3igzB:
undetectable		 2v0gA-3igzB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js6 UNCHARACTERIZED PARM
PROTEIN

(Staphylococcus
aureus) 		no annotation 4 TYR A 201
ASP A 199
SER A 122
TYR A 330
 None
 1.37A 2v0gA-3js6A:
undetectable		 2v0gA-3js6A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Pectobacterium
atrosepticum) 		PF00155
(Aminotran_1_2) 		4 SER A 235
TYR A 264
HIS A 103
HIS A 104
 None
EDO  A   2 (-4.8A)
EDO  A   2 ( 4.4A)
None
 1.35A 2v0gA-3ly1A:
undetectable		 2v0gA-3ly1A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7o LYMPHOCYTE ANTIGEN
86

(Mus musculus) 		PF02221
(E1_DerP2_DerF2) 		4 TYR A 145
ASP A  84
SER A  98
TYR A  97
 BEN  A 165 (-3.4A)
BEN  A 163 ( 3.2A)
BEN  A 163 ( 3.4A)
L9R  A 301 ( 3.5A)
 0.94A 2v0gA-3m7oA:
undetectable		 2v0gA-3m7oA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng0 GLUTAMINE SYNTHETASE

(Synechocystis
sp. PCC 6803) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 MET A  68
ASP A  53
SER A  55
TYR A 103
 None
 1.27A 2v0gA-3ng0A:
undetectable		 2v0gA-3ng0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s99 BASIC MEMBRANE
LIPOPROTEIN

(Brucella
abortus) 		PF02608
(Bmp) 		4 TYR A  91
TYR A 122
TYR A 253
HIS A  40
 None
 1.16A 2v0gA-3s99A:
1.3		 2v0gA-3s99A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tze TRYPTOPHANYL-TRNA
SYNTHETASE

(Encephalitozoon
cuniculi) 		PF00579
(tRNA-synt_1b) 		4 TYR A 339
ASP A 316
SER A 297
TYR A 296
 None
 1.14A 2v0gA-3tzeA:
1.3		 2v0gA-3tzeA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525) 		no annotation 4 MET A 161
ASP A 167
HIS A 143
HIS A 140
 None
 1.30A 2v0gA-3w36A:
undetectable		 2v0gA-3w36A:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		8 MET A  43
TYR A  46
ASP A  84
SER A 324
TYR A 327
TYR A 361
HIS A 367
HIS A 371
 LSS  A1638 (-3.9A)
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 ( 3.9A)
LSS  A1638 (-4.8A)
None
LSS  A1638 (-3.8A)
LSS  A1638 (-3.7A)
 0.63A 2v0gA-3ziuA:
44.1		 2v0gA-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 TYR A 327
TYR A  46
HIS A 371
HIS A 367
 LSS  A1638 (-4.8A)
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-3.8A)
 0.90A 2v0gA-3ziuA:
44.1		 2v0gA-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 TYR A 361
TYR A  46
HIS A 371
HIS A 367
 None
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-3.8A)
 1.34A 2v0gA-3ziuA:
44.1		 2v0gA-3ziuA:
32.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		4 ASP A 153
SER A 182
TYR A 185
HIS A 146
 None
None
None
ZN  A 999 ( 3.3A)
 1.17A 2v0gA-4aigA:
undetectable		 2v0gA-4aigA:
11.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		7 MET A  40
ASP A  80
SER A 496
TYR A 499
TYR A 527
HIS A 533
HIS A 537
 LEU  A1001 ( 4.3A)
LEU  A1001 (-3.9A)
LEU  A1001 ( 3.7A)
None
None
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.80A 2v0gA-4arcA:
45.3		 2v0gA-4arcA:
45.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 MET A  40
SER A 497
TYR A 499
TYR A 527
HIS A 537
 LEU  A1001 ( 4.3A)
None
None
None
LEU  A1001 (-3.6A)
 1.44A 2v0gA-4arcA:
45.3		 2v0gA-4arcA:
45.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		7 MET A  40
TYR A  43
ASP A  80
TYR A 499
TYR A 527
HIS A 533
HIS A 537
 LEU  A1001 ( 4.3A)
LEU  A1001 (-3.5A)
LEU  A1001 (-3.9A)
None
None
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.69A 2v0gA-4arcA:
45.3		 2v0gA-4arcA:
45.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asl EPA1P

([Candida]
glabrata) 		PF10528
(GLEYA) 		4 ASP A  69
SER A  67
TYR A  68
TYR A  88
 NA  A 304 (-3.1A)
None
None
None
 1.09A 2v0gA-4aslA:
undetectable		 2v0gA-4aslA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b29 DIMETHYLSULFONIOPROP
IONATE LYASE

(Roseovarius
nubinhibens) 		PF16867
(DMSP_lyase) 		4 ASP A 191
SER A  80
TYR A  81
TYR A 124
 None
None
None
PO4  A1197 (-4.6A)
 1.33A 2v0gA-4b29A:
undetectable		 2v0gA-4b29A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia porcellus) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 TYR A 571
SER A 319
TYR A 578
HIS A 616
 SO4  A1659 (-4.7A)
None
None
FAD  A 999 (-3.9A)
 1.29A 2v0gA-4bc7A:
undetectable		 2v0gA-4bc7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4coy EPITHELIAL ADHESIN 6

([Candida]
glabrata) 		PF10528
(GLEYA) 		4 ASP A  69
SER A  67
TYR A  68
TYR A  88
 ACT  A1273 (-3.3A)
ACT  A1273 (-2.6A)
None
None
 1.06A 2v0gA-4coyA:
undetectable		 2v0gA-4coyA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgk PHYTOENE
DEHYDROGENASE

(Pantoea
ananatis) 		PF01593
(Amino_oxidase) 		4 ASP A  51
TYR A 371
TYR A 351
HIS A 322
 EDO  A 602 (-4.6A)
EDO  A 602 (-4.3A)
None
None
 1.14A 2v0gA-4dgkA:
undetectable		 2v0gA-4dgkA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 4 SER A 382
TYR A 480
HIS A 412
HIS A 383
 None
 1.14A 2v0gA-4ecoA:
undetectable		 2v0gA-4ecoA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 ASP C 554
SER C 509
TYR C 557
TYR C 465
 None
 1.39A 2v0gA-4hb4C:
undetectable		 2v0gA-4hb4C:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN

(Pseudomonas) 		PF01804
(Penicil_amidase) 		4 MET B 515
ASP B 481
SER B 518
HIS B  60
 None
 1.22A 2v0gA-4hstB:
undetectable		 2v0gA-4hstB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC

(Rattus
norvegicus) 		no annotation 4 MET E 232
SER E 386
TYR E 380
HIS E 439
 None
 1.30A 2v0gA-4kprE:
undetectable		 2v0gA-4kprE:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwm HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 MET A 226
SER A 181
TYR A  91
HIS A 179
 None
 1.29A 2v0gA-4kwmA:
undetectable		 2v0gA-4kwmA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mea PREDICTED PROTEIN

(Acinetobacter
nosocomialis) 		PF00561
(Abhydrolase_1) 		4 TYR A 235
SER A 183
TYR A 193
HIS A 206
 None
 1.39A 2v0gA-4meaA:
undetectable		 2v0gA-4meaA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		4 ASP A 230
SER A 272
TYR A 317
HIS A 308
 None
 1.38A 2v0gA-4n0rA:
2.1		 2v0gA-4n0rA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo2 CHLOROPHENOL-4-MONOO
XYGENASE

(Streptomyces
globisporus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 ASP A 122
SER A 120
TYR A 123
TYR A 465
 None
 1.23A 2v0gA-4oo2A:
undetectable		 2v0gA-4oo2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE

(Entamoeba
histolytica) 		PF00459
(Inositol_P) 		4 TYR A 212
SER A 219
TYR A 248
HIS A 258
 None
 1.26A 2v0gA-4qxdA:
undetectable		 2v0gA-4qxdA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 ASP A 239
SER A  38
TYR A 295
HIS A  36
 None
 1.36A 2v0gA-4uphA:
undetectable		 2v0gA-4uphA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xze NUCLEOPROTEIN

(Hazara
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 SER A 312
TYR A 315
TYR A 112
HIS A 379
 None
 1.37A 2v0gA-4xzeA:
undetectable		 2v0gA-4xzeA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yog 3C-LIKE PROTEINASE

(Tylonycteris
bat coronavirus
HKU4) 		PF05409
(Peptidase_C30) 		4 SER A 147
TYR A 164
HIS A 175
HIS A 166
 None
None
None
4F5  A 405 (-4.2A)
 1.37A 2v0gA-4yogA:
undetectable		 2v0gA-4yogA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ASP A  68
SER A  63
TYR A  96
HIS A 131
 None
 1.06A 2v0gA-4zo6A:
2.4		 2v0gA-4zo6A:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		8 MET A  38
TYR A  41
ASP A  78
SER A 493
TYR A 496
TYR A 523
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.53A 2v0gA-5ah5A:
47.1		 2v0gA-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		4 TYR A 496
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 0.86A 2v0gA-5ah5A:
47.1		 2v0gA-5ah5A:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT

(Sulfurisphaera
tokodaii;
Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N)
PF17147
(PFOR_II)
PF02775
(TPP_enzyme_C)
PF12367
(PFO_beta_C) 		4 ASP B  90
SER B 129
TYR B 121
TYR A 254
 MG  B 403 ( 3.1A)
None
TPP  B 402 (-4.2A)
TPP  B 402 (-4.6A)
 1.34A 2v0gA-5b47B:
undetectable		 2v0gA-5b47B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd2 ENDO-1,4-D-GLUCANASE

(Aliivibrio
fischeri) 		PF01270
(Glyco_hydro_8) 		4 TYR A 203
ASP A 136
TYR A  79
TYR A 359
 None
GOL  A 402 (-2.9A)
None
None
 1.39A 2v0gA-5cd2A:
undetectable		 2v0gA-5cd2A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy3 GLUCANASE

(Klebsiella
pneumoniae) 		PF01270
(Glyco_hydro_8) 		4 TYR A 175
ASP A 110
TYR A 316
HIS A  51
 None
 1.36A 2v0gA-5gy3A:
undetectable		 2v0gA-5gy3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i33 ADENYLOSUCCINATE
SYNTHETASE

(Cryptococcus
neoformans) 		PF00709
(Adenylsucc_synt) 		4 TYR A 237
ASP A 234
SER A 249
TYR A 329
 None
 1.12A 2v0gA-5i33A:
undetectable		 2v0gA-5i33A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldf GLUTAMINE SYNTHETASE

(Salmonella
enterica) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 MET A  65
ASP A  50
SER A  52
TYR A 100
 None
 1.37A 2v0gA-5ldfA:
undetectable		 2v0gA-5ldfA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		4 MET B  72
TYR B  80
TYR B  83
HIS B 304
 None
None
K  B 605 ( 3.2A)
None
 1.15A 2v0gA-5m99B:
2.5		 2v0gA-5m99B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2

(Homo sapiens) 		no annotation 4 ASP A 536
SER A 539
TYR A 532
HIS A 508
 None
 1.37A 2v0gA-5o0yA:
undetectable		 2v0gA-5o0yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 4 MET A  23
ASP A  19
TYR A  27
HIS A 589
 None
 1.24A 2v0gA-5oynA:
undetectable		 2v0gA-5oynA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum) 		no annotation 4 TYR A  38
ASP A  35
TYR A 170
TYR A 146
 TYR  A  38 ( 1.3A)
ASP  A  35 ( 0.6A)
TYR  A 170 ( 1.3A)
TYR  A 146 ( 1.3A)
 1.30A 2v0gA-5w0aA:
undetectable		 2v0gA-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1j THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Echinococcus
granulosus) 		no annotation 4 MET A 328
SER A 484
TYR A 478
HIS A 537
 None
 1.28A 2v0gA-5w1jA:
undetectable		 2v0gA-5w1jA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		4 ASP A 433
SER A   2
HIS A  45
HIS A  48
 None
 1.33A 2v0gA-5wwtA:
undetectable		 2v0gA-5wwtA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqj BETA-XYLOSIDASE

(Bacillus
pumilus) 		no annotation 4 ASP A 477
SER A 475
TYR A 460
TYR A 527
 None
 1.28A 2v0gA-5zqjA:
undetectable		 2v0gA-5zqjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 4 ASP A 405
SER A 474
TYR A 431
HIS A 478
 None
 1.39A 2v0gA-6eksA:
undetectable		 2v0gA-6eksA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f79 -

(-) 		no annotation 4 ASP A 260
TYR A 149
HIS A  69
HIS A  68
 0X9  A 407 (-4.3A)
None
ZN  A 401 ( 3.1A)
None
 1.24A 2v0gA-6f79A:
1.7		 2v0gA-6f79A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g21 PROBABLE FERULOYL
ESTERASE B-2

(Aspergillus
oryzae) 		no annotation 4 TYR A 327
ASP A 323
SER A 122
HIS A 118
 None
 1.22A 2v0gA-6g21A:
undetectable		 2v0gA-6g21A:
undetectable