SIMILAR PATTERNS OF AMINO ACIDS FOR 2UZ2_A_ACTA1123

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)


(Trypanosoma
cruzi)
PF00155
(Aminotran_1_2)
4 ASN A  48
LEU A  49
THR A  44
VAL A 256
None
None
None
LLP  A 253 ( 4.1A)
1.17A 2uz2A-1bw0A:
undetectable
2uz2A-1bw0A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezi CMP-N-ACETYLNEURAMIN
IC ACID SYNTHETASE


(Neisseria
meningitidis)
PF02348
(CTP_transf_3)
4 ASN A 181
SER A 129
THR A 197
VAL A 131
None
1.18A 2uz2A-1eziA:
undetectable
2uz2A-1eziA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE


(Staphylococcus
aureus)
PF01565
(FAD_binding_4)
PF02873
(MurB_C)
4 LEU A  99
SER A  97
TYR A  52
THR A  54
None
0.96A 2uz2A-1hskA:
undetectable
2uz2A-1hskA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA


(Bacillus
thuringiensis)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid)
4 ASN A 336
LEU A 316
SER A 334
THR A 332
None
1.02A 2uz2A-1i5pA:
undetectable
2uz2A-1i5pA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida)
no annotation 4 LEU B 261
TYR B 199
THR B 259
VAL B 300
None
1.03A 2uz2A-1jmzB:
undetectable
2uz2A-1jmzB:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9w GENERAL SECRETION
PATHWAY PROTEIN E


(Vibrio cholerae)
PF00437
(T2SSE)
4 LEU A 493
SER A 492
THR A 491
VAL A 486
None
1.15A 2uz2A-1p9wA:
undetectable
2uz2A-1p9wA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT


(Paracoccus
denitrificans)
no annotation 4 LEU B 221
TYR B 203
THR B 219
VAL B 236
None
1.12A 2uz2A-1pbyB:
undetectable
2uz2A-1pbyB:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1swf CIRCULARLY PERMUTED
CORE-STREPTAVIDIN
E51/A46


(Streptomyces
avidinii)
PF01382
(Avidin)
5 ASN A  23
LEU A  25
SER A  27
TYR A  43
TRP A  92
None
0.38A 2uz2A-1swfA:
undetectable
2uz2A-1swfA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE


(Thermotoga
maritima)
PF02547
(Queuosine_synth)
4 ASN A  59
LEU A 199
SER A  61
VAL A 201
None
1.12A 2uz2A-1vkyA:
undetectable
2uz2A-1vkyA:
15.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wbi AVIDIN-RELATED
PROTEIN 2


(Gallus gallus)
PF01382
(Avidin)
6 ASN A  12
LEU A  14
SER A  16
TYR A  33
THR A  35
VAL A  37
BTN  A1001 (-3.3A)
BTN  A1001 ( 4.8A)
BTN  A1001 (-2.7A)
BTN  A1001 (-4.6A)
BTN  A1001 (-3.8A)
BTN  A1001 (-4.9A)
0.36A 2uz2A-1wbiA:
20.4
2uz2A-1wbiA:
48.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wbi AVIDIN-RELATED
PROTEIN 2


(Gallus gallus)
PF01382
(Avidin)
5 ASN A 116
LEU A  14
TYR A  33
THR A  35
VAL A  37
BTN  A1001 (-3.4A)
BTN  A1001 ( 4.8A)
BTN  A1001 (-4.6A)
BTN  A1001 (-3.8A)
BTN  A1001 (-4.9A)
1.05A 2uz2A-1wbiA:
20.4
2uz2A-1wbiA:
48.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdi HYPOTHETICAL PROTEIN
TT0907


(Thermus
thermophilus)
PF02547
(Queuosine_synth)
4 ASN A  61
LEU A 209
SER A  63
VAL A 211
CIT  A1322 (-4.4A)
None
None
None
1.14A 2uz2A-1wdiA:
undetectable
2uz2A-1wdiA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpx CARBOXYPEPTIDASE Y
INHIBITOR


(Saccharomyces
cerevisiae)
PF01161
(PBP)
4 LEU B 666
SER B 711
TYR B 515
VAL B 664
None
1.19A 2uz2A-1wpxB:
undetectable
2uz2A-1wpxB:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x90 INVERTASE/PECTIN
METHYLESTERASE
INHIBITOR FAMILY
PROTEIN


(Arabidopsis
thaliana)
PF04043
(PMEI)
4 ASN A 144
LEU A 140
SER A 143
VAL A 101
None
1.16A 2uz2A-1x90A:
undetectable
2uz2A-1x90A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE


(Pseudomonas
aeruginosa)
PF00581
(Rhodanese)
4 LEU A 299
SER A 302
TYR A 294
VAL A 328
None
1.08A 2uz2A-1yt8A:
undetectable
2uz2A-1yt8A:
12.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a8g AVIDIN

(Gallus gallus)
PF01382
(Avidin)
5 ASN A  12
LEU A  14
SER A  16
TYR A  33
THR A  35
None
0.64A 2uz2A-2a8gA:
19.4
2uz2A-2a8gA:
54.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c1q BIOTIN BINDING
PROTEIN A


(Gallus gallus)
PF01382
(Avidin)
6 ASN A  12
LEU A  14
SER A  16
TYR A  33
THR A  35
VAL A  37
BTN  A1126 (-3.3A)
BTN  A1126 (-4.8A)
BTN  A1126 (-2.6A)
BTN  A1126 (-4.5A)
BTN  A1126 (-3.6A)
None
0.29A 2uz2A-2c1qA:
20.1
2uz2A-2c1qA:
49.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c1q BIOTIN BINDING
PROTEIN A


(Gallus gallus)
PF01382
(Avidin)
5 ASN A 119
LEU A  14
TYR A  33
THR A  35
VAL A  37
BTN  A1126 (-3.2A)
BTN  A1126 (-4.8A)
BTN  A1126 (-4.5A)
BTN  A1126 (-3.6A)
None
1.17A 2uz2A-2c1qA:
20.1
2uz2A-2c1qA:
49.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c4i AVIDIN

(Gallus gallus)
PF01382
(Avidin)
5 ASN A  63
LEU A  93
TYR A 112
THR A 114
VAL A 116
BTN  A1274 (-3.2A)
BTN  A1274 ( 4.9A)
BTN  A1274 (-4.5A)
BTN  A1274 (-3.7A)
BTN  A1274 (-4.9A)
1.10A 2uz2A-2c4iA:
4.7
2uz2A-2c4iA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c4i AVIDIN

(Gallus gallus)
PF01382
(Avidin)
6 ASN A  91
LEU A  93
SER A  95
TYR A 112
THR A 114
VAL A 116
BTN  A1274 (-3.3A)
BTN  A1274 ( 4.9A)
BTN  A1274 (-2.7A)
BTN  A1274 (-4.5A)
BTN  A1274 (-3.7A)
BTN  A1274 (-4.9A)
0.36A 2uz2A-2c4iA:
4.7
2uz2A-2c4iA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c4i AVIDIN

(Gallus gallus)
PF01382
(Avidin)
5 ASN A 184
LEU A 214
TYR A 233
THR A 235
VAL A 237
BTN  A1275 (-3.2A)
BTN  A1275 (-4.8A)
BTN  A1275 (-4.6A)
BTN  A1275 (-3.7A)
BTN  A1275 (-4.8A)
1.10A 2uz2A-2c4iA:
4.7
2uz2A-2c4iA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c4i AVIDIN

(Gallus gallus)
PF01382
(Avidin)
6 ASN A 212
LEU A 214
SER A 216
TYR A 233
THR A 235
VAL A 237
BTN  A1275 (-3.2A)
BTN  A1275 (-4.8A)
BTN  A1275 (-2.6A)
BTN  A1275 (-4.6A)
BTN  A1275 (-3.7A)
BTN  A1275 (-4.8A)
0.36A 2uz2A-2c4iA:
4.7
2uz2A-2c4iA:
31.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyg BETA-1, 3-GLUCANANSE

(Musa acuminata)
PF00332
(Glyco_hydro_17)
4 ASN A 324
SER A 269
THR A 278
VAL A 335
None
1.14A 2uz2A-2cygA:
undetectable
2uz2A-2cygA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czq CUTINASE-LIKE
PROTEIN


(Cryptococcus
sp. S-2)
PF01083
(Cutinase)
4 ASN A 126
LEU A 123
THR A 157
VAL A 154
None
1.03A 2uz2A-2czqA:
undetectable
2uz2A-2czqA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d52 PENTAKETIDE CHROMONE
SYNTHASE


(Aloe
arborescens)
PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C)
4 LEU A 399
THR A 397
VAL A 299
TRP A 316
None
0.97A 2uz2A-2d52A:
undetectable
2uz2A-2d52A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fb5 HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN


(Bacillus cereus)
PF02457
(DisA_N)
PF10372
(YojJ)
4 ASN A 150
LEU A 139
SER A 147
THR A 113
None
1.16A 2uz2A-2fb5A:
undetectable
2uz2A-2fb5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fb5 HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN


(Bacillus cereus)
PF02457
(DisA_N)
PF10372
(YojJ)
4 ASN A 150
LEU A 139
THR A 113
VAL A 146
None
1.04A 2uz2A-2fb5A:
undetectable
2uz2A-2fb5A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fhl AVIDIN-RELATED
PROTEIN 4/5


(Gallus gallus)
PF01382
(Avidin)
6 ASN A  12
LEU A  14
SER A  16
TYR A  33
THR A  35
VAL A  37
BNI  A 501 (-3.4A)
BNI  A 501 ( 4.9A)
BNI  A 501 (-2.7A)
BNI  A 501 (-4.6A)
BNI  A 501 (-3.6A)
BNI  A 501 (-4.9A)
0.38A 2uz2A-2fhlA:
20.9
2uz2A-2fhlA:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fhl AVIDIN-RELATED
PROTEIN 4/5


(Gallus gallus)
PF01382
(Avidin)
5 ASN A 116
LEU A  14
TYR A  33
THR A  35
VAL A  37
BNI  A 501 (-3.3A)
BNI  A 501 ( 4.9A)
BNI  A 501 (-4.6A)
BNI  A 501 (-3.6A)
BNI  A 501 (-4.9A)
1.13A 2uz2A-2fhlA:
20.9
2uz2A-2fhlA:
56.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h84 STEELY1

(Dictyostelium
discoideum)
PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C)
4 LEU A2962
SER A2961
TYR A2842
VAL A2839
None
1.08A 2uz2A-2h84A:
undetectable
2uz2A-2h84A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqm GLUTATHIONE
REDUCTASE


(Saccharomyces
cerevisiae)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 LEU A  51
TYR A  26
THR A  49
VAL A 132
None
1.10A 2uz2A-2hqmA:
undetectable
2uz2A-2hqmA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H


(Escherichia
coli)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
4 LEU X 227
SER X 311
TYR X 255
THR X 559
None
1.17A 2uz2A-2iv2X:
undetectable
2uz2A-2iv2X:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwb METHICILLIN
RESISTANCE MECR1
PROTEIN


(Staphylococcus
aureus)
PF00905
(Transpeptidase)
4 ASN A 491
TYR A 342
THR A 344
VAL A 346
None
1.12A 2uz2A-2iwbA:
undetectable
2uz2A-2iwbA:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgs CIRCULAR PERMUTANT
OF AVIDIN


(Gallus gallus)
PF01382
(Avidin)
6 ASN A 104
LEU A 106
SER A 108
TYR A 125
THR A 127
VAL A 129
BTN  A1001 ( 4.4A)
None
BTN  A1001 (-2.6A)
BTN  A1001 (-4.5A)
BTN  A1001 (-3.7A)
None
0.37A 2uz2A-2jgsA:
undetectable
2uz2A-2jgsA:
35.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lnv GENERAL SECRETION
PATHWAY PROTEIN C


(Dickeya
dadantii)
PF11356
(T2SSC)
4 ASN A  94
LEU A  95
TYR A 147
VAL A 128
None
1.11A 2uz2A-2lnvA:
undetectable
2uz2A-2lnvA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE


(Nostoc
punctiforme)
PF00221
(Lyase_aromatic)
4 ASN A 152
LEU A 151
THR A  46
VAL A  41
None
1.17A 2uz2A-2nyfA:
undetectable
2uz2A-2nyfA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410)
4 ASN A 205
LEU A 173
SER A 207
THR A 175
None
None
NAD  A1002 (-4.7A)
NAD  A1002 (-4.3A)
1.17A 2uz2A-2o4cA:
undetectable
2uz2A-2o4cA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)
PROTEIN (HELICASE
PCRA)


(Geobacillus
stearothermophilus;
Geobacillus
stearothermophilus)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
PF13361
(UvrD_C)
4 ASN A 297
LEU A 293
TYR B 605
THR B 609
None
1.10A 2uz2A-2pjrA:
undetectable
2uz2A-2pjrA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB


(Staphylococcus
aureus)
PF00781
(DAGK_cat)
4 LEU A 178
SER A 262
THR A 264
VAL A 176
None
1.07A 2uz2A-2qvlA:
undetectable
2uz2A-2qvlA:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uz2 XENAVIDIN

(Xenopus
tropicalis)
PF01382
(Avidin)
7 ASN A  14
LEU A  16
SER A  18
TYR A  35
THR A  37
VAL A  39
TRP A  78
ACT  A1123 (-3.4A)
ACT  A1123 ( 4.7A)
ACT  A1123 (-2.5A)
ACT  A1123 (-4.5A)
ACT  A1123 (-3.8A)
ACT  A1123 (-4.9A)
None
0.00A 2uz2A-2uz2A:
24.8
2uz2A-2uz2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE


(Amycolatopsis
orientalis)
PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N)
4 ASN A 854
LEU A 868
THR A 820
VAL A 821
None
1.18A 2uz2A-2x05A:
undetectable
2uz2A-2x05A:
9.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y32 BLR5658 PROTEIN

(Bradyrhizobium
japonicum)
PF01382
(Avidin)
4 ASN A   9
SER A  13
TYR A  31
TRP A  75
None
0.54A 2uz2A-2y32A:
13.3
2uz2A-2y32A:
32.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsc TAMAVIDIN2

(Pleurotus
cornucopiae)
PF01382
(Avidin)
6 ASN A  14
LEU A  16
SER A  18
TYR A  34
VAL A  38
TRP A  80
BTN  A 301 (-3.4A)
BTN  A 301 ( 4.9A)
BTN  A 301 (-2.6A)
BTN  A 301 (-4.5A)
BTN  A 301 (-4.8A)
BTN  A 301 (-4.8A)
0.29A 2uz2A-2zscA:
15.8
2uz2A-2zscA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120)
PF00805
(Pentapeptide)
4 ASN X 116
LEU X 141
SER X 118
THR X 143
None
1.05A 2uz2A-3du1X:
undetectable
2uz2A-3du1X:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ew2 RHIZAVIDIN

(Rhizobium etli)
PF01382
(Avidin)
4 ASN A  21
SER A  25
TYR A  41
TRP A  85
BTN  A 400 (-3.6A)
BTN  A 400 (-2.6A)
BTN  A 400 (-4.4A)
BTN  A 400 ( 4.7A)
0.22A 2uz2A-3ew2A:
14.7
2uz2A-3ew2A:
28.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7m SENSOR PROTEIN

(Geobacter
sulfurreducens)
PF00497
(SBP_bac_3)
4 ASN A  82
TYR A 238
THR A 139
VAL A 276
None
1.16A 2uz2A-3h7mA:
undetectable
2uz2A-3h7mA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbx GLUTAMATE
DECARBOXYLASE 1


(Arabidopsis
thaliana)
PF00282
(Pyridoxal_deC)
4 ASN A 232
LEU A 228
VAL A 196
TRP A 237
None
1.17A 2uz2A-3hbxA:
undetectable
2uz2A-3hbxA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdy UDP-GALACTOPYRANOSE
MUTASE


(Deinococcus
radiodurans)
PF03275
(GLF)
PF13450
(NAD_binding_8)
4 LEU A 191
SER A 159
THR A 196
VAL A 195
None
None
GDU  A 500 (-4.6A)
GDU  A 500 (-4.9A)
1.17A 2uz2A-3hdyA:
undetectable
2uz2A-3hdyA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE


(Shewanella
amazonensis)
PF08668
(HDOD)
4 SER A 121
THR A 120
VAL A 117
TRP A 212
None
0.97A 2uz2A-3i7aA:
undetectable
2uz2A-3i7aA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip3 OXIDOREDUCTASE,
PUTATIVE


(Thermotoga
maritima)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 LEU A  78
SER A  77
THR A 172
VAL A  75
None
1.10A 2uz2A-3ip3A:
undetectable
2uz2A-3ip3A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6e OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY


(Aeromonas
hydrophila)
PF00106
(adh_short)
4 LEU A  58
SER A 111
THR A 112
VAL A 115
None
1.18A 2uz2A-3l6eA:
undetectable
2uz2A-3l6eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mue PANTOTHENATE
SYNTHETASE


(Salmonella
enterica)
PF02569
(Pantoate_ligase)
4 ASN A 139
SER A 135
TYR A 168
VAL A 109
None
1.13A 2uz2A-3mueA:
undetectable
2uz2A-3mueA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nh9 ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
6, MITOCHONDRIAL


(Homo sapiens)
PF00005
(ABC_tran)
4 LEU A 583
SER A 661
THR A 658
VAL A 657
None
1.13A 2uz2A-3nh9A:
undetectable
2uz2A-3nh9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwn KINESIN-LIKE PROTEIN
KIF9


(Homo sapiens)
PF00225
(Kinesin)
4 LEU A 142
SER A 140
TYR A 223
THR A 221
UNX  A1005 ( 4.4A)
UNX  A1005 ( 2.9A)
None
UNX  A1005 ( 3.9A)
0.95A 2uz2A-3nwnA:
undetectable
2uz2A-3nwnA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB


(Thermus
thermophilus)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 SER A 246
TYR A 244
THR A 155
VAL A 153
None
1.05A 2uz2A-3oa0A:
undetectable
2uz2A-3oa0A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988


(Thermus
thermophilus)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
4 LEU A 133
TYR A 112
THR A 157
VAL A 152
None
0.99A 2uz2A-3oepA:
undetectable
2uz2A-3oepA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzu ENDOGLUCANASE

(Bacillus
subtilis)
PF00150
(Cellulase)
4 LEU A 271
SER A 274
THR A 260
VAL A 269
None
1.09A 2uz2A-3pzuA:
undetectable
2uz2A-3pzuA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q10 PANTOATE--BETA-ALANI
NE LIGASE


(Yersinia pestis)
PF02569
(Pantoate_ligase)
4 ASN A 139
SER A 135
TYR A 168
VAL A 109
None
1.04A 2uz2A-3q10A:
undetectable
2uz2A-3q10A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN


(Staphylococcus
aureus)
PF00149
(Metallophos)
PF02872
(5_nucleotid_C)
4 LEU A  77
SER A  74
TYR A 102
THR A 106
None
1.01A 2uz2A-3qfkA:
undetectable
2uz2A-3qfkA:
13.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3re5 STREPTAVIDIN

(Streptomyces
avidinii)
PF01382
(Avidin)
6 ASN A  23
LEU A  25
SER A  27
TYR A  43
VAL A  47
TRP A  92
None
0.61A 2uz2A-3re5A:
15.7
2uz2A-3re5A:
33.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2x AVIDIN/STREPTAVIDIN

(Shewanella
denitrificans)
PF01382
(Avidin)
4 ASN A  15
SER A  19
TYR A  36
TRP A  80
None
0.38A 2uz2A-3t2xA:
15.7
2uz2A-3t2xA:
28.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdp FORMATE/NITRITE
TRANSPORTER


(Clostridioides
difficile)
PF01226
(Form_Nir_trans)
4 ASN A 115
LEU A  82
THR A  80
VAL A  75
None
1.10A 2uz2A-3tdpA:
undetectable
2uz2A-3tdpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A


(Mycobacterium
tuberculosis)
PF00005
(ABC_tran)
4 ASN A 677
LEU A 698
THR A 865
VAL A 866
None
1.02A 2uz2A-3zqjA:
undetectable
2uz2A-3zqjA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0t PUP--PROTEIN LIGASE

(Corynebacterium
glutamicum)
PF03136
(Pup_ligase)
4 ASN A  57
SER A  59
TYR A  71
THR A  73
None
None
None
ADP  A1478 (-3.9A)
0.85A 2uz2A-4b0tA:
undetectable
2uz2A-4b0tA:
14.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bbo BLR5658 PROTEIN

(Bradyrhizobium
japonicum)
PF01382
(Avidin)
4 ASN A   9
SER A  13
TYR A  31
TRP A  75
BTN  A1001 (-3.3A)
BTN  A1001 (-2.6A)
BTN  A1001 (-4.9A)
BTN  A1001 (-4.9A)
0.23A 2uz2A-4bboA:
14.6
2uz2A-4bboA:
36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bj8 ZEBAVIDIN

(Danio rerio)
PF01382
(Avidin)
7 ASN A  14
LEU A  16
SER A  18
TYR A  33
THR A  35
VAL A  37
TRP A  78
BTN  A1123 (-3.7A)
BTN  A1123 ( 4.8A)
BTN  A1123 (-2.8A)
BTN  A1123 (-4.5A)
BTN  A1123 (-3.8A)
None
BTN  A1123 (-4.9A)
0.35A 2uz2A-4bj8A:
18.5
2uz2A-4bj8A:
32.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
4 ASN A 301
LEU A 297
TYR A 612
THR A 616
None
1.17A 2uz2A-4c30A:
undetectable
2uz2A-4c30A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3


(Saccharomyces
cerevisiae)
PF00415
(RCC1)
PF05207
(zf-CSL)
4 ASN A 240
LEU A 259
THR A 277
TRP A 235
None
1.10A 2uz2A-4d4pA:
undetectable
2uz2A-4d4pA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dag FUSION GLYCOPROTEIN
F0


(Human
metapneumovirus)
PF00523
(Fusion_gly)
4 LEU A  39
SER A  37
THR A 281
VAL A 278
None
1.13A 2uz2A-4dagA:
undetectable
2uz2A-4dagA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dne STREPTAVIDIN

(Streptomyces
avidinii)
PF01382
(Avidin)
6 ASN A  23
LEU A  25
SER A  27
TYR A  43
THR A  45
TRP A  92
DTB  A 201 (-3.4A)
DTB  A 201 ( 4.7A)
DTB  A 201 (-2.6A)
DTB  A 201 (-4.7A)
DTB  A 201 (-3.7A)
DTB  A 201 ( 4.5A)
0.35A 2uz2A-4dneA:
16.6
2uz2A-4dneA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fer EXPANSIN-YOAJ

(Bacillus
subtilis)
PF03330
(DPBB_1)
4 ASN A  86
SER A  84
TYR A  18
VAL A  67
None
1.17A 2uz2A-4ferA:
undetectable
2uz2A-4ferA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0a UNCHARACTERIZED
PROTEIN


(Staphylococcus
aureus)
PF00188
(CAP)
PF14504
(CAP_assoc_N)
4 LEU A 189
SER A 190
TYR A 116
THR A 118
None
1.04A 2uz2A-4h0aA:
undetectable
2uz2A-4h0aA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix8 TYROSINE
AMINOTRANSFERASE


(Leishmania
infantum)
PF00155
(Aminotran_1_2)
4 ASN A  86
LEU A  87
THR A  82
VAL A 289
None
None
None
LLP  A 286 ( 3.7A)
1.17A 2uz2A-4ix8A:
undetectable
2uz2A-4ix8A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3o OUTER MEMBRANE USHER
PROTEIN FIMD


(Escherichia
coli)
PF00577
(Usher)
PF13953
(PapC_C)
PF13954
(PapC_N)
4 LEU D 417
SER D 393
TYR D 366
VAL D 320
None
0.96A 2uz2A-4j3oD:
4.6
2uz2A-4j3oD:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6o METALLOPHOSPHOESTERA
SE


(Ruminiclostridium
thermocellum)
PF00149
(Metallophos)
4 LEU A 383
TYR A 374
THR A 388
VAL A 385
None
1.12A 2uz2A-4j6oA:
undetectable
2uz2A-4j6oA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnj STREPTAVIDIN/RHIZAVI
DIN HYBRID


(Streptomyces
avidinii)
PF01382
(Avidin)
4 ASN A  23
SER A  27
TYR A  43
TRP A  92
BTN  A 201 (-3.4A)
BTN  A 201 (-2.6A)
BTN  A 201 (-4.6A)
BTN  A 201 ( 4.8A)
0.14A 2uz2A-4jnjA:
14.8
2uz2A-4jnjA:
28.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jo6 STREPTAVIDIN

(Streptomyces
avidinii)
PF01382
(Avidin)
5 ASN A  23
LEU A  25
SER A  27
TYR A  43
TRP A  92
None
0.70A 2uz2A-4jo6A:
15.6
2uz2A-4jo6A:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jo6 STREPTAVIDIN
SBP-TAG


(Streptomyces
avidinii;
)
PF01382
(Avidin)
no annotation
5 ASN A  23
LEU A  25
SER A  27
TYR A  43
VAL Y  13
None
1.30A 2uz2A-4jo6A:
15.6
2uz2A-4jo6A:
32.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh3 ANTIGEN 43

(Escherichia
coli)
PF16168
(AIDA)
4 LEU A 470
SER A 473
THR A 454
VAL A 451
None
1.06A 2uz2A-4kh3A:
undetectable
2uz2A-4kh3A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4q S-ADENOSYLMETHIONINE
SYNTHASE


(Thermococcus
kodakarensis)
PF01941
(AdoMet_Synthase)
4 ASN A 294
LEU A 296
TYR A 169
VAL A  26
None
1.10A 2uz2A-4l4qA:
undetectable
2uz2A-4l4qA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)


(Streptococcus
agalactiae)
PF10425
(SdrG_C_C)
4 SER A 484
TYR A 498
THR A 500
VAL A 482
None
1.17A 2uz2A-4mboA:
undetectable
2uz2A-4mboA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrp ABC TRANSPORTER
RELATED PROTEIN


(Novosphingobium
aromaticivorans)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
4 LEU A 354
SER A 432
THR A 429
VAL A 428
None
1.10A 2uz2A-4mrpA:
undetectable
2uz2A-4mrpA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s13 FERULIC ACID
DECARBOXYLASE 1


(Saccharomyces
cerevisiae)
PF01977
(UbiD)
4 ASN A 463
LEU A 404
TYR A 470
VAL A 367
None
1.15A 2uz2A-4s13A:
undetectable
2uz2A-4s13A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4std SCYTALONE
DEHYDRATASE


(Magnaporthe
grisea)
PF02982
(Scytalone_dh)
4 ASN A 131
LEU A 106
SER A 129
VAL A 108
BFS  A 173 (-3.4A)
BFS  A 173 (-4.5A)
BFS  A 173 (-3.3A)
BFS  A 173 ( 4.4A)
1.06A 2uz2A-4stdA:
undetectable
2uz2A-4stdA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv2 SPERMIDINE SYNTHASE,
PUTATIVE


(Trypanosoma
cruzi)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
4 ASN A 200
LEU A 245
TYR A 185
VAL A 227
None
1.11A 2uz2A-4yv2A:
undetectable
2uz2A-4yv2A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2v AVIDIN FAMILY

(Hoeflea
phototrophica)
PF01382
(Avidin)
4 ASN A  22
SER A  26
TYR A  48
TRP A  94
None
0.36A 2uz2A-4z2vA:
14.4
2uz2A-4z2vA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL


(Homo sapiens)
PF03129
(HGTP_anticodon)
4 LEU B 385
TYR B 432
THR B 440
VAL B 441
None
1.09A 2uz2A-4ztuB:
undetectable
2uz2A-4ztuB:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2


(Saccharomyces
cerevisiae)
PF00909
(Ammonium_transp)
4 LEU A 120
SER A 119
TYR A 374
VAL A 117
None
1.18A 2uz2A-5aexA:
undetectable
2uz2A-5aexA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz0 REPLICASE
POLYPROTEIN 1AB


(Avian
coronavirus)
PF08715
(Viral_protease)
4 ASN A 100
LEU A  94
TYR A 141
TRP A 102
None
1.09A 2uz2A-5bz0A:
undetectable
2uz2A-5bz0A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c53 POL GAMMA B

(Homo sapiens)
PF03129
(HGTP_anticodon)
4 LEU B 385
TYR B 432
THR B 440
VAL B 441
None
1.10A 2uz2A-5c53B:
undetectable
2uz2A-5c53B:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF13476
(AAA_23)
4 LEU A 119
SER A 117
THR A  96
VAL A  94
None
1.03A 2uz2A-5dacA:
undetectable
2uz2A-5dacA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE


(Pyrococcus
horikoshii)
PF02449
(Glyco_hydro_42)
4 ASN A 169
LEU A 166
SER A 168
VAL A 275
None
0.94A 2uz2A-5gslA:
undetectable
2uz2A-5gslA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilg PHOTORECEPTOR
DEHYDROGENASE,
ISOFORM C


(Drosophila
melanogaster)
PF00106
(adh_short)
4 ASN A  89
SER A 113
TYR A  74
VAL A  64
None
None
None
NAD  A 302 (-3.6A)
1.17A 2uz2A-5ilgA:
undetectable
2uz2A-5ilgA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgj UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE


(Aspergillus
fumigatus)
PF01209
(Ubie_methyltran)
4 LEU A 280
THR A 282
VAL A 213
TRP A 193
None
1.05A 2uz2A-5jgjA:
undetectable
2uz2A-5jgjA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens)
PF03538
(VRP1)
4 ASN A2374
SER A2390
TYR A1982
THR A2483
None
1.18A 2uz2A-5lkiA:
undetectable
2uz2A-5lkiA:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens)
PF03538
(VRP1)
4 LEU A1949
SER A 110
THR A 108
VAL A 104
None
1.14A 2uz2A-5lkiA:
undetectable
2uz2A-5lkiA:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN


(Segniliparus
rugosus)
PF00501
(AMP-binding)
PF00550
(PP-binding)
4 ASN A 710
LEU A 706
SER A 709
VAL A 722
None
0.96A 2uz2A-5mswA:
undetectable
2uz2A-5mswA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN


(Shewanella
loihica)
no annotation 4 ASN A  79
LEU A  83
THR A  77
VAL A  85
None
1.17A 2uz2A-5x8zA:
undetectable
2uz2A-5x8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bp2 ENVELOPE
GLYCOPROTEIN


(Marburg
marburgvirus)
no annotation 4 ASN A  80
SER A 151
TYR A 155
THR A 153
None
0.98A 2uz2A-6bp2A:
undetectable
2uz2A-6bp2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3


(Sus scrofa)
no annotation 4 ASN C  55
LEU C 159
SER C  57
VAL C 151
None
1.09A 2uz2A-6exvC:
undetectable
2uz2A-6exvC:
undetectable