SIMILAR PATTERNS OF AMINO ACIDS FOR 2UXP_B_CLMB1211

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8q BROMOPEROXIDASE A1

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		5 HIS A  26
ALA A  92
GLY A  98
ILE A 121
VAL A 225
 None
 1.17A 2uxpB-1a8qA:
undetectable		 2uxpB-1a8qA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azz COLLAGENASE

(Leptuca
pugilator) 		PF00089
(Trypsin) 		5 ALA A  32
VAL A  81
GLY A  44
ILE A  52
VAL A 112
 None
 1.21A 2uxpB-1azzA:
undetectable		 2uxpB-1azzA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Escherichia
coli) 		PF02126
(PTE) 		5 HIS A 148
ALA A 147
VAL A 177
GLY A  82
ILE A 126
 None
 1.21A 2uxpB-1bf6A:
0.0		 2uxpB-1bf6A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE BETA
CHAIN

(Sphingomonas
paucimobilis) 		PF02900
(LigB) 		5 HIS B 105
ALA B 107
GLY B  76
ILE B 148
VAL B 185
 None
 1.21A 2uxpB-1bouB:
0.0		 2uxpB-1bouB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnp DNA PHOTOLYASE

(Escherichia
coli) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 HIS A 340
ALA A 230
GLU A 413
GLY A 412
ILE A 415
 None
 1.27A 2uxpB-1dnpA:
0.7		 2uxpB-1dnpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3b GLUTATHIONE
S-TRANSFERASE YA
CHAIN

(Mus musculus) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 HIS A 142
GLU A  87
VAL A 138
GLY A  82
ILE A  91
 None
 1.23A 2uxpB-1f3bA:
0.0		 2uxpB-1f3bA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		5 ALA A 198
SER A 199
GLY A 284
ILE A 482
VAL A 464
 FAD  A1031 (-3.4A)
None
FAD  A1031 (-3.6A)
None
None
 1.27A 2uxpB-1h7wA:
0.0		 2uxpB-1h7wA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii8 RAD50 ABC-ATPASE
RAD50 ABC-ATPASE

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF13476
(AAA_23)
PF13304
(AAA_21) 		5 ALA B 752
MET B 808
GLY B 801
ILE A 146
VAL B 776
 None
 1.17A 2uxpB-1ii8B:
undetectable		 2uxpB-1ii8B:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 134
CYH A 430
GLY A 432
ILE A 433
VAL A 417
 None
 1.11A 2uxpB-1itzA:
1.1		 2uxpB-1itzA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		5 ALA A 239
VAL A 166
CYH A 248
GLY A 244
ILE A 246
 None
 1.06A 2uxpB-1kcxA:
0.0		 2uxpB-1kcxA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mx3 C-TERMINAL BINDING
PROTEIN 1

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 123
SER A 124
GLY A  99
ILE A  98
VAL A  40
 None
None
ACY  A4000 ( 3.8A)
None
None
 1.31A 2uxpB-1mx3A:
0.0		 2uxpB-1mx3A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 ALA A 285
CYH A 340
GLY A 191
ILE A 195
VAL A 333
 None
 1.14A 2uxpB-1pgjA:
undetectable		 2uxpB-1pgjA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF13476
(AAA_23)
no annotation 		5 ALA B 752
MET B 808
GLY B 801
ILE A 146
VAL B 776
 None
 1.15A 2uxpB-1us8B:
undetectable		 2uxpB-1us8B:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf1 GLUTATHIONE
S-TRANSFERASE 3

(Gallus gallus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 HIS A 143
GLU A  88
VAL A 139
GLY A  83
ILE A  92
 None
 1.20A 2uxpB-1vf1A:
undetectable		 2uxpB-1vf1A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A 310
VAL A 348
CYH A 401
GLY A 402
ILE A 330
 None
 1.25A 2uxpB-1w78A:
undetectable		 2uxpB-1w78A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6j L-LACTATE
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A 239
MET A  26
GLY A  19
ILE A  12
VAL A  77
 None
 1.31A 2uxpB-1y6jA:
undetectable		 2uxpB-1y6jA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a74 COMPLEMENT COMPONENT
C3C

(Homo sapiens) 		PF00207
(A2M) 		5 ALA B 893
VAL B 864
GLY B 902
ILE B 809
VAL B 874
 GOL  B 701 (-3.5A)
None
None
None
None
 1.29A 2uxpB-2a74B:
undetectable		 2uxpB-2a74B:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a87 THIOREDOXIN
REDUCTASE

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		5 ALA A 286
VAL A 269
GLY A  21
ILE A  20
VAL A 257
 None
None
FAD  A 348 (-3.1A)
None
None
 1.22A 2uxpB-2a87A:
undetectable		 2uxpB-2a87A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLU A   8
VAL A  19
GLY A   7
ILE A  33
VAL A  69
 None
 1.24A 2uxpB-2ag1A:
undetectable		 2uxpB-2ag1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2auj DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN

(Thermus
aquaticus) 		no annotation 5 ALA D 369
GLU D 376
VAL D 355
ILE D 378
VAL D 361
 None
 1.06A 2uxpB-2aujD:
undetectable		 2uxpB-2aujD:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjs UNC-13 HOMOLOG A
REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2

(Rattus
norvegicus;
Rattus
norvegicus) 		PF00168
(C2)
no annotation 		5 ALA C 117
SER A   2
GLU A  52
GLY C 105
VAL C 130
 None
EDO  A1155 (-3.3A)
EDO  A1155 (-3.6A)
EDO  A1155 (-3.5A)
GOL  C1145 (-4.7A)
 1.14A 2uxpB-2cjsC:
undetectable		 2uxpB-2cjsC:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqc ARGININE/SERINE-RICH
SPLICING FACTOR 10

(Homo sapiens) 		PF00076
(RRM_1) 		5 ALA A 175
GLU A 174
VAL A 122
GLY A 142
ILE A 144
 None
 1.27A 2uxpB-2cqcA:
undetectable		 2uxpB-2cqcA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4w GLYCEROL KINASE

(Cellulomonas
sp.) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 HIS A 228
ALA A  75
VAL A 235
GLY A 242
ILE A  78
 None
 1.20A 2uxpB-2d4wA:
undetectable		 2uxpB-2d4wA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dm4 SORTILIN-RELATED
RECEPTOR

(Homo sapiens) 		PF00041
(fn3) 		5 ALA A  22
GLU A  23
VAL A  27
GLY A 102
ILE A 100
 None
 1.23A 2uxpB-2dm4A:
undetectable		 2uxpB-2dm4A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 ALA A 177
VAL A 170
GLY A 424
ILE A 425
VAL A 151
 None
 1.00A 2uxpB-2e0wA:
0.0		 2uxpB-2e0wA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gn1 THREONINE
DEHYDRATASE
CATABOLIC

(Salmonella
enterica) 		PF00291
(PALP) 		5 ALA A 284
GLU A 282
VAL A 208
GLY A 312
ILE A 310
 LLP  A  58 ( 3.4A)
LLP  A  58 ( 3.7A)
None
LLP  A  58 ( 3.5A)
None
 1.11A 2uxpB-2gn1A:
undetectable		 2uxpB-2gn1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1

(Mus musculus) 		PF00595
(PDZ) 		5 ALA A 288
VAL A 252
GLY A 263
ILE A 264
VAL A 335
 None
 1.18A 2uxpB-2mx6A:
undetectable		 2uxpB-2mx6A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1

(Mus musculus) 		PF00595
(PDZ) 		5 ALA A 291
VAL A 252
GLY A 263
ILE A 264
VAL A 335
 None
 1.22A 2uxpB-2mx6A:
undetectable		 2uxpB-2mx6A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6t DNAB REPLICATION
FORK HELICASE

(Thermus
aquaticus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 HIS A 169
SER A 201
GLY A 353
ILE A 354
VAL A 230
 None
 1.11A 2uxpB-2q6tA:
1.9		 2uxpB-2q6tA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A 544
GLU A 536
GLY A 533
ILE A 537
VAL A 876
 None
 1.28A 2uxpB-2qo3A:
undetectable		 2uxpB-2qo3A:
14.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR

(Pseudomonas
putida) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		11 HIS A  67
HIS A  70
ALA A  74
SER A  77
GLU A  78
MET A  89
VAL A  96
CYH A 137
GLY A 140
ILE A 141
VAL A 171
 None
 0.48A 2uxpB-2uxoA:
31.8		 2uxpB-2uxoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR

(Pseudomonas
putida) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		6 HIS A  70
ALA A  74
SER A  77
GLU A  78
VAL A  96
VAL A 195
 None
 1.31A 2uxpB-2uxoA:
31.8		 2uxpB-2uxoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyy N-PAC PROTEIN

(Homo sapiens) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 HIS A 291
SER A 394
GLY A 421
ILE A 401
VAL A 358
 None
None
K  A1554 (-4.2A)
None
None
 1.21A 2uxpB-2uyyA:
undetectable		 2uxpB-2uyyA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 HIS A 196
MET A 221
CYH A 259
GLY A 256
VAL A 235
 None
 1.03A 2uxpB-2v55A:
0.4		 2uxpB-2v55A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Bacillus
subtilis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 GLU A 292
MET A 207
VAL A 250
GLY A 289
VAL A 199
 None
 1.16A 2uxpB-2xd4A:
undetectable		 2uxpB-2xd4A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yue PROTEIN NEURALIZED

(Drosophila
melanogaster) 		PF07177
(Neuralized) 		5 ALA A  37
CYH A 154
GLY A 152
ILE A  66
VAL A  53
 None
 1.04A 2uxpB-2yueA:
undetectable		 2uxpB-2yueA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zle PROTEASE DO

(Escherichia
coli) 		PF00595
(PDZ)
PF13365
(Trypsin_2) 		5 ALA A 116
GLU A 175
VAL A 202
GLY A 174
VAL A  64
 None
 1.24A 2uxpB-2zleA:
undetectable		 2uxpB-2zleA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zle PROTEASE DO

(Escherichia
coli) 		PF00595
(PDZ)
PF13365
(Trypsin_2) 		5 ALA A 116
GLU A 175
VAL A 202
ILE A 113
VAL A  64
 None
 1.16A 2uxpB-2zleA:
undetectable		 2uxpB-2zleA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		5 HIS A 152
ALA A 488
MET A 169
VAL A 176
GLY A 484
 None
 1.24A 2uxpB-3ahiA:
undetectable		 2uxpB-3ahiA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdx SUCCINYLGLUTAMATEDES
UCCINYLASE/ASPARTOAC
YLASE

(Rhodobacter
sphaeroides) 		PF04952
(AstE_AspA) 		5 HIS A 238
VAL A 241
GLY A 231
ILE A 232
VAL A  88
 None
 1.08A 2uxpB-3cdxA:
undetectable		 2uxpB-3cdxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cij UPF0100 PROTEIN
AF_0094

(Archaeoglobus
fulgidus) 		PF13531
(SBP_bac_11) 		5 HIS A  58
ALA A  53
GLU A 310
VAL A  63
VAL A  86
 None
 1.05A 2uxpB-3cijA:
undetectable		 2uxpB-3cijA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		5 HIS C 266
SER C 227
GLY C 271
ILE C 195
VAL C 206
 None
 1.13A 2uxpB-3degC:
undetectable		 2uxpB-3degC:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e35 UNCHARACTERIZED
PROTEIN SCO1997

(Streptomyces
coelicolor) 		PF09754
(PAC2) 		6 SER A 138
MET A  31
VAL A  18
GLY A 127
ILE A 129
VAL A  61
 None
 1.42A 2uxpB-3e35A:
undetectable		 2uxpB-3e35A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edm SHORT CHAIN
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF13561
(adh_short_C2) 		5 ALA A  12
CYH A  22
GLY A  19
ILE A  18
VAL A 183
 None
 1.08A 2uxpB-3edmA:
undetectable		 2uxpB-3edmA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etc AMP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 HIS A 109
ALA A  77
GLY A  86
ILE A  85
VAL A 140
 None
 1.08A 2uxpB-3etcA:
undetectable		 2uxpB-3etcA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9w TALIN-2

(Mus musculus) 		PF00373
(FERM_M)
PF02174
(IRS) 		5 ALA A 363
VAL A 359
GLY A 388
ILE A 391
VAL A 340
 None
 1.20A 2uxpB-3g9wA:
undetectable		 2uxpB-3g9wA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h07 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Yersinia pestis) 		PF00926
(DHBP_synthase) 		5 HIS A 153
VAL A  31
CYH A  69
GLY A 142
ILE A 158
 None
 1.26A 2uxpB-3h07A:
undetectable		 2uxpB-3h07A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq0 PUTATIVE RIBOKINASE
II

(Escherichia
coli) 		PF00294
(PfkB) 		5 HIS A 133
ALA A  37
GLU A   9
GLY A   8
VAL A  76
 None
 1.16A 2uxpB-3iq0A:
undetectable		 2uxpB-3iq0A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		5 HIS A 431
SER A 460
VAL A 433
CYH A 448
ILE A 447
 None
 1.22A 2uxpB-3k40A:
undetectable		 2uxpB-3k40A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg9 CURK

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		5 HIS A1116
ALA A1144
GLY A1180
ILE A1179
VAL A1240
 None
 1.19A 2uxpB-3kg9A:
undetectable		 2uxpB-3kg9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF04816
(TrmK) 		5 HIS A  62
ALA A  27
SER A  24
VAL A  34
ILE A   2
 None
 1.29A 2uxpB-3kr9A:
undetectable		 2uxpB-3kr9A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8u PUTATIVE RRNA
METHYLASE

(Streptococcus
mutans) 		PF00588
(SpoU_methylase) 		5 HIS A  19
HIS A 112
ALA A 161
GLY A 169
ILE A 168
 None
 1.26A 2uxpB-3l8uA:
undetectable		 2uxpB-3l8uA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3max HISTONE DEACETYLASE
2

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 VAL A 262
CYH A 266
GLY A 267
ILE A 180
VAL A 293
 None
 1.25A 2uxpB-3maxA:
undetectable		 2uxpB-3maxA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owa ACYL-COA
DEHYDROGENASE

(Bacillus
anthracis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 HIS A 112
HIS A 115
GLY A 265
ILE A 264
VAL A 124
 None
 1.30A 2uxpB-3owaA:
undetectable		 2uxpB-3owaA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Vibrio cholerae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ALA A  90
VAL A  68
GLY A 130
ILE A 127
VAL A 157
 None
 1.15A 2uxpB-3p4eA:
undetectable		 2uxpB-3p4eA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv4 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 SER A 281
MET A 248
VAL A 252
GLY A 287
VAL A 308
 None
 1.29A 2uxpB-3pv4A:
undetectable		 2uxpB-3pv4A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		5 HIS A 128
ALA A 108
VAL A  43
GLY A 146
ILE A 147
 None
NAD  A 400 (-3.3A)
None
None
None
 1.29A 2uxpB-3qbdA:
undetectable		 2uxpB-3qbdA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz1 STEROID
21-HYDROXYLASE

(Bos taurus) 		PF00067
(p450) 		5 ALA A 296
VAL A 440
GLY A 291
ILE A 172
VAL A 140
 None
None
HEM  A 500 (-3.6A)
None
None
 1.32A 2uxpB-3qz1A:
undetectable		 2uxpB-3qz1A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh9 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(NAD(P)(+))

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		5 SER A  21
MET A  44
VAL A 218
ILE A  14
VAL A 177
 None
 1.24A 2uxpB-3rh9A:
undetectable		 2uxpB-3rh9A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slu M23 PEPTIDASE DOMAIN
PROTEIN

(Neisseria
meningitidis) 		PF01551
(Peptidase_M23) 		5 HIS A 343
GLU A 377
VAL A 308
GLY A 297
ILE A 298
 None
 1.14A 2uxpB-3sluA:
undetectable		 2uxpB-3sluA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u8v METAL-BINDING
PROTEIN SMBP

(Nitrosomonas
europaea) 		PF16785
(SMBP) 		5 HIS A   3
ALA A  10
SER A  36
GLY A  55
ILE A  56
 None
 1.22A 2uxpB-3u8vA:
undetectable		 2uxpB-3u8vA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u8v METAL-BINDING
PROTEIN SMBP

(Nitrosomonas
europaea) 		PF16785
(SMBP) 		5 HIS A   3
HIS A   6
ALA A  10
GLY A  55
ILE A  56
 None
NI  A  94 (-3.2A)
None
None
None
 0.81A 2uxpB-3u8vA:
undetectable		 2uxpB-3u8vA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9l 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		5 ALA A 245
VAL A 251
GLY A  16
ILE A   8
VAL A  90
 None
 1.22A 2uxpB-3u9lA:
undetectable		 2uxpB-3u9lA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 SER A 242
GLU A 380
GLY A 168
ILE A 171
VAL A 186
 None
 1.16A 2uxpB-3wd8A:
undetectable		 2uxpB-3wd8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		5 ALA A 677
VAL A 683
GLY A 472
ILE A 473
VAL A 540
 None
 0.95A 2uxpB-3wfzA:
0.8		 2uxpB-3wfzA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zid TUBULIN/FTSZ, GTPASE

(Methanothrix
thermoacetophila) 		PF00091
(Tubulin) 		5 ALA A 207
SER A 210
GLU A 211
GLY A 306
ILE A 307
 None
 1.26A 2uxpB-3zidA:
undetectable		 2uxpB-3zidA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Cryptococcus
neoformans) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ALA B 433
MET B  88
GLY B 471
ILE B 344
VAL B 476
 None
IMP  B1527 (-4.0A)
IMP  B1527 (-3.1A)
None
None
 1.15A 2uxpB-4af0B:
undetectable		 2uxpB-4af0B:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 5 HIS A  53
ALA A 344
SER A 343
GLY A 282
ILE A 283
 L6S  A1610 (-4.0A)
L6S  A1610 ( 4.5A)
None
None
GLA  A1608 ( 4.7A)
 1.30A 2uxpB-4aw7A:
undetectable		 2uxpB-4aw7A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkx HISTONE DEACETYLASE
1

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 VAL B 257
CYH B 261
GLY B 262
ILE B 175
VAL B 288
 None
 1.20A 2uxpB-4bkxB:
undetectable		 2uxpB-4bkxB:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN

(Methylobacillus
flagellatus) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 ALA A  97
CYH A 161
GLY A 160
ILE A 157
VAL A  67
 None
 1.32A 2uxpB-4gltA:
undetectable		 2uxpB-4gltA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 HIS A 143
GLU A  88
VAL A 139
GLY A  83
ILE A  92
 None
 1.20A 2uxpB-4hj2A:
undetectable		 2uxpB-4hj2A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huj UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored) 		5 ALA A  90
VAL A 113
GLY A   8
ILE A   7
VAL A  76
 None
 1.11A 2uxpB-4hujA:
undetectable		 2uxpB-4hujA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jat ALPHA-PYRONE
SYNTHESIS POLYKETIDE
SYNTHASE-LIKE PKS11

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ALA A 297
VAL A 287
GLY A 272
ILE A 271
VAL A 257
 None
 1.18A 2uxpB-4jatA:
undetectable		 2uxpB-4jatA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgu COLH PROTEIN

(Hathewaya
histolytica) 		PF00801
(PKD) 		5 GLU A 835
VAL A 783
GLY A 834
ILE A 858
VAL A 793
 None
 1.14A 2uxpB-4jguA:
undetectable		 2uxpB-4jguA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lb8 UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF16140
(DUF4848) 		5 SER A 184
VAL A 308
GLY A 202
ILE A 293
VAL A 237
 None
 1.12A 2uxpB-4lb8A:
undetectable		 2uxpB-4lb8A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxn UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF00295
(Glyco_hydro_28) 		5 HIS A 183
MET A 212
VAL A 162
CYH A 207
ILE A 204
 None
 1.14A 2uxpB-4mxnA:
undetectable		 2uxpB-4mxnA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n54 INOSITOL
DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 HIS A 110
ALA A 107
VAL A 114
GLY A 102
ILE A 101
 None
 1.21A 2uxpB-4n54A:
undetectable		 2uxpB-4n54A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		5 ALA A 752
MET A 808
GLY A 801
ILE A 146
VAL A 776
 None
 1.25A 2uxpB-4ncjA:
undetectable		 2uxpB-4ncjA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN

(Legionella
pneumophila) 		PF14566
(PTPlike_phytase) 		5 HIS A 113
ALA A 120
SER A  42
GLY A 118
VAL A 188
 None
 1.30A 2uxpB-4tvvA:
0.4		 2uxpB-4tvvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11

(Homo sapiens) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 HIS A 103
ALA A  73
CYH A 106
GLY A 108
VAL A 149
 None
 1.18A 2uxpB-4uucA:
undetectable		 2uxpB-4uucA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Medicago
truncatula) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 ALA A  26
MET A  21
VAL A  76
ILE A 161
VAL A 125
 None
 1.22A 2uxpB-5bshA:
3.6		 2uxpB-5bshA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Medicago
truncatula) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 MET A  21
VAL A  76
GLY A  28
ILE A 161
VAL A 125
 None
 1.20A 2uxpB-5bshA:
3.6		 2uxpB-5bshA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce9 POLYPHENOL OXIDASE

(Juglans regia) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		5 HIS A 272
ALA A 263
SER A 262
GLY A 247
ILE A 254
 None
 1.17A 2uxpB-5ce9A:
undetectable		 2uxpB-5ce9A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvo WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		5 ALA A 104
VAL A 101
CYH A  85
GLY A  87
VAL A 132
 None
 1.20A 2uxpB-5cvoA:
undetectable		 2uxpB-5cvoA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dp1 CURK

(Moorea
producens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 HIS A 325
GLU A 230
GLY A 229
ILE A 232
VAL A 223
 None
 1.25A 2uxpB-5dp1A:
undetectable		 2uxpB-5dp1A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 HIS X  87
ALA X  88
MET X 217
VAL X  94
GLY X 223
 None
 1.08A 2uxpB-5evyX:
undetectable		 2uxpB-5evyX:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5o DIGUANYLATE CYCLASE

(Xanthomonas
campestris) 		PF00027
(cNMP_binding) 		5 HIS A 117
ALA A 116
MET A  61
GLY A  40
VAL A 131
 None
 1.32A 2uxpB-5h5oA:
undetectable		 2uxpB-5h5oA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6q CELL WALL BINDING
PROTEIN CWP8

(Clostridioides
difficile) 		PF04122
(CW_binding_2) 		5 SER A 295
GLU A 582
VAL A 291
GLY A 583
ILE A 584
 None
 1.06A 2uxpB-5j6qA:
undetectable		 2uxpB-5j6qA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 ALA A 170
CYH A 147
GLY A 145
ILE A 144
VAL A 247
 None
None
None
None
GOL  A 502 ( 4.9A)
 1.31A 2uxpB-5jryA:
0.9		 2uxpB-5jryA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3

(Arabidopsis
thaliana) 		PF01680
(SOR_SNZ) 		5 HIS A 179
ALA A 228
CYH A 145
GLY A 144
ILE A 162
 None
6R3  A 404 ( 4.3A)
None
EDO  A 405 (-4.1A)
None
 1.16A 2uxpB-5k2zA:
undetectable		 2uxpB-5k2zA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnt PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.1

(Arabidopsis
thaliana) 		PF01680
(SOR_SNZ) 		5 HIS A 180
ALA A 229
CYH A 146
GLY A 145
ILE A 163
 None
KPR  A 401 (-3.2A)
None
None
None
 1.18A 2uxpB-5lntA:
undetectable		 2uxpB-5lntA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 HIS A 322
ALA A 313
VAL A 306
GLY A 265
ILE A 266
 CAP  A 501 (-4.0A)
None
None
None
None
 1.25A 2uxpB-5macA:
undetectable		 2uxpB-5macA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 5 ALA A 226
VAL A 201
GLY A 315
ILE A 233
VAL A 204
 None
 1.18A 2uxpB-5n7qA:
undetectable		 2uxpB-5n7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogx CYTOCHROME P450
REDUCTASE

(Amycolatopsis
methanolica) 		no annotation 5 HIS A  54
ALA A  57
VAL A  52
GLY A  41
VAL A  85
 None
None
None
FES  A 402 (-3.7A)
None
 1.29A 2uxpB-5ogxA:
undetectable		 2uxpB-5ogxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4n FRUCTOSE-1

(Neisseria
gonorrhoeae) 		PF01116
(F_bP_aldolase) 		5 HIS A  84
SER A 116
GLY A 144
ILE A 143
VAL A 187
 PO4  A 402 (-3.6A)
None
None
None
None
 1.21A 2uxpB-5u4nA:
undetectable		 2uxpB-5u4nA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 HIS A 212
MET A 237
CYH A 275
GLY A 272
VAL A 251
 None
 0.99A 2uxpB-5u7qA:
undetectable		 2uxpB-5u7qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue1 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 ALA A   8
SER A  48
VAL A 192
GLY A  51
VAL A  95
 TRS  A 302 ( 3.7A)
None
None
None
None
 1.16A 2uxpB-5ue1A:
undetectable		 2uxpB-5ue1A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 ALA A 295
SER A 274
VAL A 336
GLY A 300
VAL A 342
 None
 1.32A 2uxpB-5w3fA:
undetectable		 2uxpB-5w3fA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE

(Mus musculus) 		no annotation 5 HIS A 529
HIS A 266
ALA A 265
SER A 335
GLY A 260
 PX8  A 610 (-3.7A)
None
None
None
None
 1.24A 2uxpB-5w7dA:
2.2		 2uxpB-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apg DISD PROTEIN

(Sorangium
cellulosum) 		no annotation 5 ALA A 143
GLU A 165
VAL A 134
ILE A 166
VAL A 126
 None
 0.93A 2uxpB-6apgA:
undetectable		 2uxpB-6apgA:
undetectable