SIMILAR PATTERNS OF AMINO ACIDS FOR 2UXP_A_CLMA1211

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)

(Escherichia
coli) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain) 		5 ALA B1627
GLU B1529
LEU B1622
LEU B1618
ILE B1552
 None
 1.34A 2uxpA-1a9xB:
undetectable		 2uxpA-1a9xB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agx GLUTAMINASE-ASPARAGI
NASE

(Acinetobacter
glutaminasificans) 		PF00710
(Asparaginase) 		5 LEU A  36
LEU A 132
ILE A  49
VAL A  87
ILE A  88
 None
 1.41A 2uxpA-1agxA:
0.4		 2uxpA-1agxA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0z PROTEIN
(PHOSPHOGLUCOSE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00342
(PGI) 		5 GLU A 128
LEU A 124
LEU A 123
VAL A  76
ILE A  78
 None
 1.37A 2uxpA-1b0zA:
0.0		 2uxpA-1b0zA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)

(Escherichia
coli) 		PF00490
(ALAD) 		5 ALA A 157
LEU A  98
CYH A 106
ILE A 105
VAL A  37
 None
 1.22A 2uxpA-1b4eA:
0.0		 2uxpA-1b4eA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8u PROTEIN (MALATE
DEHYDROGENASE)

(Aquaspirillum
arcticum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A  13
LEU A  88
ILE A  25
VAL A  86
ILE A 127
 None
 1.37A 2uxpA-1b8uA:
undetectable		 2uxpA-1b8uA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 238
LEU A 173
ILE A 227
VAL A 197
ILE A 175
 None
 1.21A 2uxpA-1bxzA:
undetectable		 2uxpA-1bxzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8b SPORE PROTEASE

(Bacillus
megaterium) 		PF03418
(Peptidase_A25) 		5 ALA A 561
LEU A 538
LEU A 753
VAL A 649
ILE A 651
 None
 1.33A 2uxpA-1c8bA:
undetectable		 2uxpA-1c8bA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ALA A 318
LEU A 319
LEU A 236
ILE A 182
VAL A 242
 None
 1.18A 2uxpA-1cliA:
0.0		 2uxpA-1cliA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)

(Salmonella
enterica) 		PF00180
(Iso_dh) 		5 ALA A 315
LEU A 309
LEU A 305
VAL A  26
ILE A 355
 None
 1.26A 2uxpA-1cnzA:
0.0		 2uxpA-1cnzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct5 PROTEIN (YEAST
HYPOTHETICAL
PROTEIN, SELENOMET)

(Saccharomyces
cerevisiae) 		PF01168
(Ala_racemase_N) 		5 LEU A 168
LEU A 177
ILE A 209
VAL A 141
ILE A 114
 None
 1.42A 2uxpA-1ct5A:
undetectable		 2uxpA-1ct5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ

(Sinorhizobium
meliloti) 		PF00072
(Response_reg) 		5 ALA A  98
LEU A  66
LEU A  65
ILE A  76
VAL A   9
 None
 1.47A 2uxpA-1dbwA:
0.0		 2uxpA-1dbwA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 ALA A 387
LEU A 346
LEU A 350
VAL A  16
ILE A  17
 None
 1.21A 2uxpA-1dedA:
0.3		 2uxpA-1dedA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnp DNA PHOTOLYASE

(Escherichia
coli) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 ALA A  64
LEU A  13
LEU A  19
ILE A  70
VAL A   5
 None
 1.25A 2uxpA-1dnpA:
undetectable		 2uxpA-1dnpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxx DYSTROPHIN

(Homo sapiens) 		PF00307
(CH) 		5 ALA A  80
LEU A  54
LEU A  53
VAL A  25
ILE A  37
 None
 1.42A 2uxpA-1dxxA:
undetectable		 2uxpA-1dxxA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 LEU C 221
LEU C 171
CYH C 228
VAL C 174
ILE C 136
 None
 1.46A 2uxpA-1ea9C:
undetectable		 2uxpA-1ea9C:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fez PHOSPHONOACETALDEHYD
E HYDROLASE

(Bacillus cereus) 		PF13419
(HAD_2) 		5 ALA A 107
GLU A 110
LEU A 252
ILE A 112
VAL A   9
 None
 1.39A 2uxpA-1fezA:
undetectable		 2uxpA-1fezA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geu GLUTATHIONE
REDUCTASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A  57
GLU A  61
LEU A 189
VAL A 170
ILE A 258
 None
 1.07A 2uxpA-1geuA:
undetectable		 2uxpA-1geuA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm1 PROTEIN TYROSINE
PHOSPHATASE

(Mus musculus) 		PF00595
(PDZ) 		5 ALA A  52
LEU A  25
LEU A  85
ILE A  59
VAL A  29
 None
 1.42A 2uxpA-1gm1A:
undetectable		 2uxpA-1gm1A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnw GLUTATHIONE
S-TRANSFERASE

(Arabidopsis
thaliana) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ALA A 114
LEU A 143
LEU A 147
ILE A 176
VAL A 194
 None
 1.36A 2uxpA-1gnwA:
undetectable		 2uxpA-1gnwA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyg L-LACTATE/MALATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLU A 247
LEU A 251
LEU A 253
ILE A 243
ILE A 121
 None
 1.02A 2uxpA-1hygA:
undetectable		 2uxpA-1hygA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 ALA A  87
LEU A  88
LEU A 103
VAL A  70
ILE A  61
 None
 1.20A 2uxpA-1i7qA:
undetectable		 2uxpA-1i7qA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 ALA A 429
GLU A  56
LEU A 424
LEU A 203
VAL A 452
 None
 1.46A 2uxpA-1iidA:
undetectable		 2uxpA-1iidA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqp RFCS

(Pyrococcus
furiosus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		5 ALA A 121
LEU A 122
LEU A 130
ILE A 153
ILE A 114
 None
 1.38A 2uxpA-1iqpA:
2.3		 2uxpA-1iqpA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jax CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF03807
(F420_oxidored) 		5 ALA A  62
LEU A   6
LEU A  70
VAL A 119
ILE A  78
 None
 1.20A 2uxpA-1jaxA:
undetectable		 2uxpA-1jaxA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jlv GLUTATHIONE
TRANSFERASE GST1-3

(Anopheles
cracens) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ALA A  19
LEU A  26
LEU A  28
ILE A 195
ILE A  52
 None
None
None
None
GSH  A 701 (-4.6A)
 1.41A 2uxpA-1jlvA:
undetectable		 2uxpA-1jlvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jro XANTHINE
DEHYDROGENASE, CHAIN
A

(Rhodobacter
capsulatus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		5 GLU A  79
LEU A  27
LEU A  26
VAL A  14
ILE A   3
 None
 1.31A 2uxpA-1jroA:
undetectable		 2uxpA-1jroA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwq N-ACETYLMURAMOYL-L-A
LANINE AMIDASE CWLV

(Paenibacillus
polymyxa) 		PF01520
(Amidase_3) 		5 ALA A  34
LEU A 141
ILE A 172
VAL A 139
ILE A 131
 None
 1.22A 2uxpA-1jwqA:
undetectable		 2uxpA-1jwqA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		5 LEU H 123
LEU H  47
ILE H 212
VAL H 105
ILE H 241
 None
 1.25A 2uxpA-1kigH:
undetectable		 2uxpA-1kigH:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkm PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
subtilis) 		PF00381
(PTS-HPr) 		5 ALA H  73
LEU H  22
ILE H  63
VAL H  50
ILE H  47
 None
None
None
SEP  H  46 ( 4.2A)
SEP  H  46 ( 3.5A)
 1.47A 2uxpA-1kkmH:
undetectable		 2uxpA-1kkmH:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkm PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
subtilis) 		PF00381
(PTS-HPr) 		5 ALA H  73
LEU H  77
LEU H  22
VAL H  50
ILE H  47
 None
None
None
SEP  H  46 ( 4.2A)
SEP  H  46 ( 3.5A)
 1.30A 2uxpA-1kkmH:
undetectable		 2uxpA-1kkmH:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ALA A  35
LEU A 113
ILE A  42
VAL A  58
ILE A  87
 None
 1.12A 2uxpA-1lxtA:
undetectable		 2uxpA-1lxtA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 GLU A  36
LEU A 113
ILE A  39
VAL A  58
ILE A  87
 None
 1.28A 2uxpA-1lxtA:
undetectable		 2uxpA-1lxtA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5h FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01913
(FTR)
PF02741
(FTR_C) 		5 GLU A 113
LEU A  84
LEU A  88
VAL A  23
ILE A  74
 None
 1.32A 2uxpA-1m5hA:
undetectable		 2uxpA-1m5hA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhq ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA2

(Homo sapiens) 		PF00790
(VHS) 		5 LEU A  26
LEU A  30
CYH A  93
VAL A  85
ILE A  46
 None
 1.33A 2uxpA-1mhqA:
2.0		 2uxpA-1mhqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Leishmania
major) 		PF00581
(Rhodanese)
PF09122
(DUF1930) 		5 ALA A 122
LEU A 117
LEU A 113
VAL A  31
ILE A  30
 None
 1.45A 2uxpA-1okgA:
undetectable		 2uxpA-1okgA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pch PHOSPHOCARRIER
PROTEIN

(Mycoplasma
capricolum) 		PF00381
(PTS-HPr) 		5 LEU A  86
LEU A  14
ILE A  63
VAL A  50
ILE A  47
 None
None
None
None
SO4  A  90 (-4.2A)
 1.25A 2uxpA-1pchA:
undetectable		 2uxpA-1pchA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q14 HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		5 ALA A 274
LEU A  99
LEU A 100
ILE A  35
VAL A 112
 None
 1.19A 2uxpA-1q14A:
undetectable		 2uxpA-1q14A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1a HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		5 ALA A 274
LEU A  99
LEU A 100
ILE A  35
VAL A 112
 None
 1.15A 2uxpA-1q1aA:
undetectable		 2uxpA-1q1aA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 ALA A 388
LEU A 347
LEU A 351
VAL A  10
ILE A  11
 None
 1.32A 2uxpA-1qhoA:
undetectable		 2uxpA-1qhoA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmv PEROXIREDOXIN-2

(Homo sapiens) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		6 ALA A  17
GLU A  27
LEU A 104
LEU A  73
VAL A  38
ILE A 132
 None
 1.35A 2uxpA-1qmvA:
undetectable		 2uxpA-1qmvA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF00899
(ThiF) 		5 LEU A 113
LEU A 139
ILE A  60
VAL A 126
ILE A 148
 None
 1.26A 2uxpA-1r4nA:
2.2		 2uxpA-1r4nA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5a GLUTATHIONE
TRANSFERASE

(Anopheles
cracens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 ALA A  21
LEU A  28
LEU A  30
ILE A 200
ILE A  54
 None
None
None
None
GTS  A1004 (-4.0A)
 1.24A 2uxpA-1r5aA:
undetectable		 2uxpA-1r5aA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		5 ALA A 187
LEU A 249
LEU A 245
VAL A 191
ILE A 130
 None
None
None
None
NAD  A 360 (-4.8A)
 1.13A 2uxpA-1rkxA:
undetectable		 2uxpA-1rkxA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rr9 ATP-DEPENDENT
PROTEASE LA

(Escherichia
coli) 		PF05362
(Lon_C) 		5 ALA A 770
LEU A 771
CYH A 685
ILE A 763
ILE A 654
 None
 1.37A 2uxpA-1rr9A:
undetectable		 2uxpA-1rr9A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si1 IRON BINDING PROTEIN
FBPA

(Mannheimia
haemolytica) 		PF13343
(SBP_bac_6) 		5 ALA A 258
LEU A 249
ILE A  15
VAL A  54
ILE A 236
 None
 1.22A 2uxpA-1si1A:
undetectable		 2uxpA-1si1A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si1 IRON BINDING PROTEIN
FBPA

(Mannheimia
haemolytica) 		PF13343
(SBP_bac_6) 		5 ALA A 258
LEU A 253
LEU A 249
VAL A  30
ILE A  32
 None
 1.29A 2uxpA-1si1A:
undetectable		 2uxpA-1si1A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA

(Leishmania
major) 		PF02580
(Tyr_Deacylase) 		5 ALA A 136
LEU A  66
LEU A  65
VAL A  40
ILE A  42
 None
 1.25A 2uxpA-1tc5A:
undetectable		 2uxpA-1tc5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1th8 ANTI-SIGMA F FACTOR
ANTAGONIST

(Geobacillus
stearothermophilus) 		PF01740
(STAS) 		5 ALA B  27
LEU B  22
LEU B  53
ILE B  64
VAL B  87
 None
 1.20A 2uxpA-1th8B:
undetectable		 2uxpA-1th8B:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u08 HYPOTHETICAL
AMINOTRANSFERASE
YBDL

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A 306
LEU A 383
ILE A 365
VAL A 347
ILE A  33
 None
 1.46A 2uxpA-1u08A:
undetectable		 2uxpA-1u08A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0s CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima) 		PF07194
(P2) 		5 ALA A 245
LEU A 203
ILE A 257
VAL A 233
ILE A 234
 None
 1.24A 2uxpA-1u0sA:
undetectable		 2uxpA-1u0sA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Mycobacterium
tuberculosis) 		PF01513
(NAD_kinase) 		5 ALA A  22
LEU A   9
LEU A  80
ILE A 121
VAL A 128
 None
 1.16A 2uxpA-1u0tA:
undetectable		 2uxpA-1u0tA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u4f INWARD RECTIFIER
POTASSIUM CHANNEL 2

(Mus musculus) 		PF01007
(IRK) 		5 LEU A 222
LEU A 263
CYH A 311
VAL A 214
ILE A 269
 None
 1.06A 2uxpA-1u4fA:
undetectable		 2uxpA-1u4fA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue6 SINGLE-STRAND
BINDING PROTEIN

(Mycobacterium
tuberculosis) 		PF00436
(SSB) 		5 ALA A  29
LEU A  71
CYH A  57
VAL A  77
ILE A  78
 None
 1.42A 2uxpA-1ue6A:
undetectable		 2uxpA-1ue6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori) 		PF01264
(Chorismate_synt) 		5 ALA A 139
LEU A  39
ILE A  79
VAL A  63
ILE A  83
 None
 1.15A 2uxpA-1umfA:
undetectable		 2uxpA-1umfA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5z MAJOR NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Aliivibrio
fischeri) 		PF00881
(Nitroreductase) 		5 ALA A 150
LEU A  36
LEU A  33
ILE A 191
VAL A  52
 None
 1.26A 2uxpA-1v5zA:
undetectable		 2uxpA-1v5zA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Thermotoga
maritima) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ALA A 157
LEU A 158
LEU A 214
ILE A 241
VAL A 224
 None
 1.00A 2uxpA-1vknA:
undetectable		 2uxpA-1vknA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 ALA A 200
GLU A 203
LEU A 157
LEU A 160
VAL A 125
 None
 1.24A 2uxpA-1vp4A:
undetectable		 2uxpA-1vp4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vq0 33 KDA CHAPERONIN

(Thermotoga
maritima) 		PF01430
(HSP33) 		5 ALA A 137
LEU A  49
ILE A 198
VAL A  17
ILE A 227
 None
 1.47A 2uxpA-1vq0A:
undetectable		 2uxpA-1vq0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wel RNA-BINDING PROTEIN
12

(Homo sapiens) 		PF00076
(RRM_1) 		5 LEU A 437
LEU A 434
ILE A 460
VAL A 432
ILE A 505
 None
 1.39A 2uxpA-1welA:
undetectable		 2uxpA-1welA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		5 ALA A 174
LEU A 175
LEU A 192
VAL A 278
ILE A 279
 None
 1.12A 2uxpA-1wl1A:
1.6		 2uxpA-1wl1A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwk PHOSPHOGLYCERATE
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 160
LEU A 161
LEU A 137
VAL A 196
ILE A 226
 None
 1.43A 2uxpA-1wwkA:
undetectable		 2uxpA-1wwkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 ALA A  55
LEU A 128
LEU A 192
VAL A  31
ILE A  38
 None
 1.27A 2uxpA-1x3lA:
undetectable		 2uxpA-1x3lA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xs3 HYPOTHETICAL PROTEIN
XC975

(Xanthomonas
euvesicatoria) 		PF01722
(BolA) 		5 ALA A  75
LEU A  79
LEU A  81
VAL A  64
ILE A  24
 None
 1.43A 2uxpA-1xs3A:
undetectable		 2uxpA-1xs3A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		5 GLU A  56
LEU A  13
LEU A 215
ILE A  53
VAL A 208
 None
 1.36A 2uxpA-1xt8A:
undetectable		 2uxpA-1xt8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y51 PHOSPHOCARRIER
PROTEIN HPR

(Geobacillus
stearothermophilus) 		PF00381
(PTS-HPr) 		5 ALA A  73
LEU A  77
LEU A  22
VAL A  50
ILE A  47
 None
 1.34A 2uxpA-1y51A:
undetectable		 2uxpA-1y51A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 LEU A  35
LEU A 184
ILE A 208
VAL A 152
ILE A 159
 None
 1.42A 2uxpA-1yq2A:
undetectable		 2uxpA-1yq2A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrw PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 ALA A 281
LEU A 296
LEU A 298
ILE A 276
VAL A 259
 None
 1.45A 2uxpA-1yrwA:
undetectable		 2uxpA-1yrwA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0x TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Enterococcus
faecalis) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 GLU A  25
LEU A  18
LEU A  17
VAL A  32
ILE A  10
 None
 1.16A 2uxpA-1z0xA:
11.1		 2uxpA-1z0xA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z47 PUTATIVE
ABC-TRANSPORTER
ATP-BINDING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 ALA A  62
LEU A  58
LEU A  46
ILE A  15
VAL A  44
 None
 1.36A 2uxpA-1z47A:
undetectable		 2uxpA-1z47A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		5 ALA A 281
LEU A 296
LEU A 298
ILE A 276
VAL A 259
 None
 1.40A 2uxpA-1z7eA:
1.4		 2uxpA-1z7eA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbs HYPOTHETICAL PROTEIN
PG1100

(Porphyromonas
gingivalis) 		PF01869
(BcrAD_BadFG) 		5 ALA A  44
LEU A  45
LEU A  82
VAL A  63
ILE A  60
 None
 1.24A 2uxpA-1zbsA:
undetectable		 2uxpA-1zbsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoq INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF10401
(IRF-3) 		5 ALA A 283
LEU A 272
LEU A 228
VAL A 206
ILE A 220
 None
 1.39A 2uxpA-1zoqA:
undetectable		 2uxpA-1zoqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		5 ALA A 247
LEU A 248
LEU A 204
VAL A 229
ILE A 182
 None
 1.18A 2uxpA-1zzmA:
undetectable		 2uxpA-1zzmA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		5 ALA A 327
LEU A 317
LEU A 292
ILE A 297
VAL A 278
 None
 1.41A 2uxpA-2aw5A:
0.3		 2uxpA-2aw5A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayu NUCLEOSOME ASSEMBLY
PROTEIN

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		5 ALA A 356
LEU A 193
ILE A 217
VAL A 199
ILE A 198
 None
 1.48A 2uxpA-2ayuA:
undetectable		 2uxpA-2ayuA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2boa CARBOXYPEPTIDASE A4

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 GLU A1072
LEU A1108
ILE A1068
VAL A1179
ILE A1183
 ZN  A1402 (-1.6A)
None
None
None
None
 1.46A 2uxpA-2boaA:
undetectable		 2uxpA-2boaA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chg REPLICATION FACTOR C
SMALL SUBUNIT

(Archaeoglobus
fulgidus) 		PF00004
(AAA) 		5 ALA A 113
LEU A 114
LEU A 122
ILE A 145
ILE A 106
 None
 1.40A 2uxpA-2chgA:
undetectable		 2uxpA-2chgA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		5 ALA A 733
LEU A 465
LEU A 474
VAL A  43
ILE A  45
 None
 1.31A 2uxpA-2cn3A:
undetectable		 2uxpA-2cn3A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqc ARGININE/SERINE-RICH
SPLICING FACTOR 10

(Homo sapiens) 		PF00076
(RRM_1) 		5 ALA A 175
GLU A 174
LEU A 120
ILE A 144
ILE A 149
 None
 1.35A 2uxpA-2cqcA:
undetectable		 2uxpA-2cqcA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu6 DTDP-4-KETO-L-RHAMNO
SE REDUCTASE-RELATED
PROTEIN

(Thermus
thermophilus) 		PF01883
(FeS_assembly_P) 		5 ALA A  13
GLU A  16
LEU A  14
LEU A  68
VAL A  38
 None
 1.41A 2uxpA-2cu6A:
undetectable		 2uxpA-2cu6A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4a MALATE DEHYDROGENASE

(Aeropyrum
pernix) 		no annotation 5 ALA B  15
LEU B 229
ILE B   2
VAL B 113
ILE B 114
 None
 1.32A 2uxpA-2d4aB:
undetectable		 2uxpA-2d4aB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dby GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		5 ALA A  20
LEU A 271
LEU A 274
ILE A   6
VAL A 207
 None
 1.31A 2uxpA-2dbyA:
undetectable		 2uxpA-2dbyA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkn 3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Pseudomonas sp.
B-0831) 		PF13561
(adh_short_C2) 		5 ALA A 109
LEU A 101
LEU A  63
CYH A  68
VAL A  55
 None
 1.29A 2uxpA-2dknA:
undetectable		 2uxpA-2dknA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 181
LEU A 285
ILE A 330
VAL A 288
ILE A 246
 None
 1.40A 2uxpA-2dphA:
undetectable		 2uxpA-2dphA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpw HYPOTHETICAL PROTEIN
TTHA0179

(Thermus
thermophilus) 		PF12804
(NTP_transf_3) 		5 ALA A 101
GLU A 219
LEU A  42
ILE A  94
VAL A   7
 None
 1.46A 2uxpA-2dpwA:
undetectable		 2uxpA-2dpwA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ego GENERAL RECEPTOR FOR
PHOSPHOINOSITIDES
1-ASSOCIATED
SCAFFOLD PROTEIN

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 ALA A 146
LEU A 103
LEU A 181
VAL A 157
ILE A 170
 None
 1.40A 2uxpA-2egoA:
undetectable		 2uxpA-2egoA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF01063
(Aminotran_4) 		5 ALA A 192
GLU A 193
LEU A 141
VAL A 263
ILE A 271
 None
PMP  A3413 (-3.3A)
None
None
None
 1.45A 2uxpA-2ej0A:
undetectable		 2uxpA-2ej0A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		5 ALA X   2
LEU X  24
LEU X  65
VAL X  41
ILE X  39
 None
 1.37A 2uxpA-2epkX:
undetectable		 2uxpA-2epkX:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		5 ALA X   2
LEU X  24
LEU X  69
VAL X  76
ILE X  78
 None
 1.25A 2uxpA-2epkX:
undetectable		 2uxpA-2epkX:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 ALA A 191
LEU A 186
LEU A 183
ILE A 138
VAL A  86
 None
 1.27A 2uxpA-2fmtA:
undetectable		 2uxpA-2fmtA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 LEU A 286
LEU A 283
ILE A 214
VAL A 274
ILE A 264
 None
 1.27A 2uxpA-2fmtA:
undetectable		 2uxpA-2fmtA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyx TRANSPOSASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF01797
(Y1_Tnp) 		5 ALA A  42
LEU A  49
LEU A  52
VAL A  59
ILE A  16
 None
 1.31A 2uxpA-2fyxA:
undetectable		 2uxpA-2fyxA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9b CALBINDIN

(Rattus
norvegicus) 		PF13405
(EF-hand_6)
PF13499
(EF-hand_7) 		5 ALA A   2
GLU A  42
LEU A   6
LEU A  82
ILE A  75
 None
 1.32A 2uxpA-2g9bA:
undetectable		 2uxpA-2g9bA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb3 ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 ALA A 134
LEU A 138
ILE A 103
VAL A 167
ILE A 166
 None
 1.36A 2uxpA-2gb3A:
undetectable		 2uxpA-2gb3A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER

(Bacillus
subtilis) 		PF07470
(Glyco_hydro_88) 		5 ALA A 307
LEU A 260
ILE A 312
VAL A 326
ILE A 329
 None
 1.42A 2uxpA-2gh4A:
undetectable		 2uxpA-2gh4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		5 ALA A 332
LEU A 361
LEU A 364
ILE A 380
VAL A 388
 None
 1.31A 2uxpA-2h21A:
undetectable		 2uxpA-2h21A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ALA A 217
GLU A 219
LEU A 236
VAL A 163
ILE A 191
 None
 1.33A 2uxpA-2hakA:
0.2		 2uxpA-2hakA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB

(Methanocaldococcus
jannaschii) 		PF02492
(cobW) 		5 GLU A  51
LEU A 200
LEU A 198
VAL A 165
ILE A 142
 None
GSP  A 300 (-4.2A)
None
None
None
 1.45A 2uxpA-2hf8A:
undetectable		 2uxpA-2hf8A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hx1 PREDICTED SUGAR
PHOSPHATASES OF THE
HAD SUPERFAMILY

(Cytophaga
hutchinsonii) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 ALA A  55
LEU A 138
ILE A 164
VAL A  99
ILE A 116
 None
 1.41A 2uxpA-2hx1A:
undetectable		 2uxpA-2hx1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 ALA A  41
GLU A  35
LEU A  32
LEU A  27
ILE A  10
 None
 1.45A 2uxpA-2i4nA:
undetectable		 2uxpA-2i4nA:
19.35