SIMILAR PATTERNS OF AMINO ACIDS FOR 2UXO_B_TACB1211_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		5 LEU A 106
LEU A  73
ILE A 195
MET A 278
ILE A  82
 None
 1.22A 2uxoB-1epxA:
0.0		 2uxoB-1epxA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1is1 RIBOSOME RECYCLING
FACTOR

(Vibrio
parahaemolyticus) 		PF01765
(RRF) 		5 LEU A  37
VAL A  78
LEU A  65
VAL A  69
ILE A  98
 None
 1.19A 2uxoB-1is1A:
1.1		 2uxoB-1is1A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 LEU A 244
VAL A 161
LEU A  63
ILE A 302
ILE A   8
 None
 1.13A 2uxoB-1kv9A:
0.0		 2uxoB-1kv9A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 LEU A 100
LEU A 339
LEU A 112
ILE A   5
VAL A  70
 None
 1.13A 2uxoB-1ptjA:
undetectable		 2uxoB-1ptjA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzs REGULATORY PROTEIN
CRO

(Salmonella
virus P22) 		PF14549
(P22_Cro) 		5 LEU A  20
VAL A  16
MET A   1
VAL A   6
ILE A   7
 None
 1.15A 2uxoB-1rzsA:
undetectable		 2uxoB-1rzsA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1u CHOLINE
O-ACETYLTRANSFERASE

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		5 LEU A 168
LEU A 130
VAL A 134
VAL A 196
ILE A 277
 None
 1.22A 2uxoB-1t1uA:
0.3		 2uxoB-1t1uA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii) 		PF01266
(DAO) 		5 LEU B  90
VAL B 242
ILE B 131
VAL B 126
ILE B 238
 None
 1.06A 2uxoB-1y56B:
0.0		 2uxoB-1y56B:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 LEU A 699
LEU A 673
VAL A 676
LEU A 425
ILE A 704
 None
 1.22A 2uxoB-2b5mA:
0.0		 2uxoB-2b5mA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)

(Escherichia
virus phiX174) 		PF02306
(Phage_G) 		5 LEU 2  32
HIS 2  58
LEU 2 161
VAL 2 159
ILE 2  79
 None
 1.13A 2uxoB-2bpa2:
undetectable		 2uxoB-2bpa2:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7l PHYCOERYTHROCYANIN
ALPHA CHAIN
PHYCOERYTHROCYANIN
BETA CHAIN

(Mastigocladus
laminosus) 		PF00502
(Phycobilisome) 		5 LEU B  38
LEU B 160
VAL B  97
LEU A  24
ILE B  51
 CYC  B1174 (-3.6A)
None
None
CYC  B1174 (-4.7A)
None
 1.11A 2uxoB-2c7lB:
0.0		 2uxoB-2c7lB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1

(Bos taurus) 		PF02274
(Amidinotransf) 		5 LEU A  59
HIS A  14
LEU A 111
LEU A 224
VAL A  82
 None
 1.17A 2uxoB-2ci6A:
undetectable		 2uxoB-2ci6A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII

(Thermococcus
kodakarensis) 		PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		5 LEU A 106
LEU A 114
VAL A 120
ILE A  92
VAL A 533
 None
 1.21A 2uxoB-2cw7A:
undetectable		 2uxoB-2cw7A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 347
VAL A 371
LEU A 429
ILE A 256
ILE A 323
 None
 1.13A 2uxoB-2db3A:
undetectable		 2uxoB-2db3A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go7 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		5 LEU A  76
LEU A  54
VAL A  50
ILE A  34
VAL A  41
 CL  A 209 ( 4.9A)
None
CL  A 209 ( 4.5A)
None
None
 1.02A 2uxoB-2go7A:
undetectable		 2uxoB-2go7A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inv INSULIN
FRUCTOTRANSFERASE

(Bacillus sp.
snu-7) 		no annotation 5 LEU A 235
VAL A 237
LEU A 185
VAL A 249
ILE A 242
 None
 0.98A 2uxoB-2invA:
undetectable		 2uxoB-2invA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivg CYANATE LYASE

(Escherichia
coli) 		PF02560
(Cyanate_lyase) 		5 LEU A  48
VAL A  43
LEU A  19
VAL A  61
ILE A  32
 None
 1.20A 2uxoB-2ivgA:
undetectable		 2uxoB-2ivgA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		5 LEU A  61
LEU A  90
ILE A  68
VAL A  82
ILE A  85
 None
None
SO4  A1437 (-3.7A)
None
None
 1.08A 2uxoB-2j3zA:
undetectable		 2uxoB-2j3zA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgh UNCHARACTERIZED
PROTEIN

(Aeromonas
hydrophila) 		PF08327
(AHSA1) 		5 LEU A  79
LEU A 125
LEU A  45
ILE A   9
ILE A  26
 None
 1.13A 2uxoB-2lghA:
undetectable		 2uxoB-2lghA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE

(Neisseria
meningitidis) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 VAL A 633
ASN A 641
ILE A 516
MET A 513
VAL A 578
 None
 1.09A 2uxoB-2olsA:
undetectable		 2uxoB-2olsA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqz SORTASE B

(Bacillus
anthracis) 		PF04203
(Sortase) 		5 LEU A 177
VAL A 228
ASN A 126
ILE A  92
ILE A 136
 None
 1.16A 2uxoB-2oqzA:
undetectable		 2uxoB-2oqzA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B

(Bos taurus) 		PF00400
(WD40) 		5 LEU C 335
LEU C 362
ILE C 371
VAL C 259
ILE C 332
 None
 1.19A 2uxoB-2p9nC:
undetectable		 2uxoB-2p9nC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjq UNCHARACTERIZED
PROTEIN LP_2664

(Lactobacillus
plantarum) 		PF01966
(HD) 		5 HIS A  29
VAL A  33
LEU A 181
ILE A  97
VAL A 119
 None
 1.14A 2uxoB-2pjqA:
undetectable		 2uxoB-2pjqA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 LEU A 182
VAL A  20
LEU A  90
VAL A  94
ILE A  10
 None
None
None
NAD  A 401 ( 4.8A)
None
 1.07A 2uxoB-2plaA:
0.9		 2uxoB-2plaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjn RESPONSE REGULATOR
RECEIVER:METAL-DEPEN
DENT
PHOSPHOHYDROLASE, HD
SUBDOMAIN

(Neptuniibacter
caesariensis) 		PF00072
(Response_reg) 		5 LEU A 124
VAL A 120
LEU A  20
ILE A  80
VAL A  83
 None
 1.22A 2uxoB-2rjnA:
undetectable		 2uxoB-2rjnA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vo1 CTP SYNTHASE 1

(Homo sapiens) 		PF06418
(CTP_synth_N) 		5 LEU A 267
VAL A 262
LEU A  32
CYH A 176
ILE A  26
 None
 1.19A 2uxoB-2vo1A:
undetectable		 2uxoB-2vo1A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 LEU A 511
LEU A 618
ASN A 463
LEU A 466
VAL A 568
 None
 1.11A 2uxoB-2vxoA:
undetectable		 2uxoB-2vxoA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yax SULFUR
OXYGENASE/REDUCTASE

(Acidianus
ambivalens) 		PF07682
(SOR) 		5 LEU B  97
VAL B  30
ASN B  45
ILE B 207
MET B 210
 None
 1.21A 2uxoB-2yaxB:
undetectable		 2uxoB-2yaxB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		5 LEU A  65
HIS A  62
LEU A  37
VAL A   8
ILE A  55
 None
 1.20A 2uxoB-2zj8A:
2.0		 2uxoB-2zj8A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		5 LEU A 553
LEU A 466
VAL A 538
LEU A 577
ILE A 514
 None
 1.22A 2uxoB-3a6pA:
2.7		 2uxoB-3a6pA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw2 2-NITROPROPANE
DIOXYGENASE

(Streptomyces
ansochromogenes) 		PF03060
(NMO) 		5 LEU A 149
VAL A 161
LEU A   5
VAL A 207
ILE A 209
 None
 1.01A 2uxoB-3bw2A:
undetectable		 2uxoB-3bw2A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 LEU A 347
LEU A 631
ILE A 364
MET A 398
ILE A 811
 None
 1.22A 2uxoB-3f2bA:
undetectable		 2uxoB-3f2bA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE

(Pseudomonas
protegens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  41
LEU A 360
LEU A  81
ILE A 276
ILE A  89
 None
 1.12A 2uxoB-3fj4A:
undetectable		 2uxoB-3fj4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs3 RIBOSE OPERON
REPRESSOR

(Lactobacillus
acidophilus) 		PF13377
(Peripla_BP_3) 		5 HIS A 291
LEU A 294
ILE A  62
VAL A 138
ILE A 152
 None
 1.18A 2uxoB-3hs3A:
undetectable		 2uxoB-3hs3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1

(Schizosaccharomyces
pombe) 		PF00498
(FHA) 		5 LEU A 184
CYH A 204
ILE A 208
VAL A 152
ILE A 118
 None
 1.22A 2uxoB-3i0mA:
undetectable		 2uxoB-3i0mA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		5 LEU A 350
VAL A 452
ILE A 466
VAL A 444
ILE A 425
 None
 0.99A 2uxoB-3i6sA:
1.0		 2uxoB-3i6sA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kez PUTATIVE SUGAR
BINDING PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ASN A 477
LEU A 460
CYH A 190
ILE A 171
ILE A 463
 EDO  A   4 (-4.0A)
None
None
None
None
 1.02A 2uxoB-3kezA:
undetectable		 2uxoB-3kezA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv8 THYMIDYLATE KINASE

(Vibrio cholerae) 		PF02223
(Thymidylate_kin) 		5 LEU A  70
LEU A  63
LEU A 121
ILE A 157
ILE A 113
 None
None
None
TMP  A 214 (-3.3A)
None
 1.21A 2uxoB-3lv8A:
undetectable		 2uxoB-3lv8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1g PUTATIVE GLUTATHIONE
S-TRANSFERASE

(Corynebacterium
glutamicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		5 LEU A  80
LEU A 138
ASN A 159
LEU A 173
ILE A 156
 None
None
None
None
GOL  A 364 (-4.6A)
 1.18A 2uxoB-3m1gA:
undetectable		 2uxoB-3m1gA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qye TBC1 DOMAIN FAMILY
MEMBER 1

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 HIS A 794
LEU A 992
ASN A1043
ILE A 809
ILE A1042
 None
 1.16A 2uxoB-3qyeA:
undetectable		 2uxoB-3qyeA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r50 IPOMOELIN

(Ipomoea batatas) 		PF01419
(Jacalin) 		5 LEU A  32
LEU A  37
ILE A 100
VAL A  64
ILE A  62
 None
 1.22A 2uxoB-3r50A:
undetectable		 2uxoB-3r50A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry7 RIBOKINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 LEU A 264
LEU A 212
ILE A 275
VAL A 184
ILE A 183
 None
 1.10A 2uxoB-3ry7A:
undetectable		 2uxoB-3ry7A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 LEU A 898
LEU A 916
ASN A 894
ILE A 766
ILE A 889
 None
 1.09A 2uxoB-3s5kA:
undetectable		 2uxoB-3s5kA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8j PURINE NUCLEOSIDASE,
(IUNH-1)

(Sulfolobus
solfataricus) 		PF01156
(IU_nuc_hydro) 		5 LEU A 116
LEU A  21
VAL A  28
ILE A 121
VAL A  31
 None
None
None
NA  A 401 (-4.3A)
None
 1.18A 2uxoB-3t8jA:
undetectable		 2uxoB-3t8jA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujq LEGUME LECTIN

(Lablab
purpureus) 		PF00139
(Lectin_legB) 		5 LEU A 197
VAL A 217
ILE A  79
VAL A 143
ILE A 164
 None
 1.12A 2uxoB-3ujqA:
undetectable		 2uxoB-3ujqA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uki OXYR

(Porphyromonas
gingivalis) 		PF03466
(LysR_substrate) 		5 LEU A 105
VAL A 109
LEU A 282
VAL A 124
ILE A 122
 None
 1.17A 2uxoB-3ukiA:
undetectable		 2uxoB-3ukiA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		5 HIS B1658
LEU B1738
VAL B1736
MET B1806
ILE B1665
 None
 0.89A 2uxoB-3zefB:
undetectable		 2uxoB-3zefB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PDX2 PROTEIN

(Plasmodium
falciparum) 		PF01174
(SNO) 		5 LEU G  11
LEU G  68
ILE G  32
VAL G  48
ILE G  49
 None
 1.06A 2uxoB-4adsG:
undetectable		 2uxoB-4adsG:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b43 TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N) 		5 LEU A 231
LEU A  93
ILE A 215
VAL A 148
ILE A 146
 None
 1.13A 2uxoB-4b43A:
undetectable		 2uxoB-4b43A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7a TRNA
THREONYLCARBAMOYLADE
NOSINE DEHYDRATASE

(Escherichia
coli) 		PF00899
(ThiF) 		5 VAL A 109
LEU A 181
CYH A 142
VAL A  36
ILE A 129
 AMP  A 401 (-4.2A)
None
None
AMP  A 401 (-4.8A)
AMP  A 401 (-4.1A)
 1.00A 2uxoB-4d7aA:
undetectable		 2uxoB-4d7aA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di4 TATP(T) (TP0957)

(Treponema
pallidum) 		PF03480
(DctP) 		5 LEU B  87
LEU B  28
ILE B  93
VAL B 130
ILE B 131
 None
 1.19A 2uxoB-4di4B:
undetectable		 2uxoB-4di4B:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eca L-ASPARAGINE
AMIDOHYDROLASE

(Escherichia
coli) 		PF00710
(Asparaginase) 		5 LEU A 129
VAL A 110
LEU A  42
ILE A 187
ILE A   4
 None
 1.12A 2uxoB-4ecaA:
undetectable		 2uxoB-4ecaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN

(Rhizobium etli) 		PF01408
(GFO_IDH_MocA) 		5 LEU A 214
VAL A 140
LEU A 250
VAL A 177
ILE A 232
 None
 1.00A 2uxoB-4ew6A:
undetectable		 2uxoB-4ew6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn1 RAS-ASSOCIATED AND
PLECKSTRIN HOMOLOGY
DOMAINS-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH)
PF00788
(RA) 		5 LEU A 297
VAL A 296
MET A 277
VAL A 275
ILE A 273
 None
 1.17A 2uxoB-4gn1A:
undetectable		 2uxoB-4gn1A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu3 OXYGEN SENSOR
PROTEIN DOSP

(Escherichia
coli) 		PF00563
(EAL) 		5 VAL A 634
LEU A 646
ILE A 595
VAL A 611
ILE A 612
 None
 1.19A 2uxoB-4hu3A:
undetectable		 2uxoB-4hu3A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jip GTN REDUCTASE

(Agrobacterium
tumefaciens) 		PF00724
(Oxidored_FMN) 		5 LEU A 256
LEU A 231
ILE A  13
VAL A 175
ILE A 177
 None
 1.20A 2uxoB-4jipA:
0.3		 2uxoB-4jipA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjz TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N)
PF11987
(IF-2) 		5 LEU A 231
LEU A  93
ILE A 215
VAL A 148
ILE A 146
 None
 1.22A 2uxoB-4kjzA:
undetectable		 2uxoB-4kjzA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Mycobacterium
avium) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		5 LEU A 182
VAL A 242
LEU A 333
VAL A 329
ILE A 204
 None
 1.16A 2uxoB-4lgvA:
undetectable		 2uxoB-4lgvA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m3c LECTIN BETA CHAIN

(Butea
monosperma) 		PF00139
(Lectin_legB) 		5 LEU B 178
VAL B 198
ILE B  59
VAL B 123
ILE B 145
 None
 1.15A 2uxoB-4m3cB:
undetectable		 2uxoB-4m3cB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3

(Brucella
melitensis) 		PF13458
(Peripla_BP_6) 		5 VAL A 119
LEU A  68
ILE A 338
VAL A 307
ILE A 308
 None
 0.95A 2uxoB-4n0qA:
undetectable		 2uxoB-4n0qA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n27 BACTERIAL
TRANSFERASE
HEXAPEPTIDE REPEAT

(Brucella
abortus) 		PF00132
(Hexapep) 		5 VAL A 123
LEU A 134
ILE A  82
VAL A 111
ILE A 129
 None
 1.13A 2uxoB-4n27A:
undetectable		 2uxoB-4n27A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 LEU A 680
LEU A 749
LEU A 683
VAL A 755
ILE A 756
 None
 1.19A 2uxoB-4nc6A:
undetectable		 2uxoB-4nc6A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovd PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 174
VAL A 169
LEU A 231
ILE A 260
ILE A 235
 None
 1.19A 2uxoB-4ovdA:
undetectable		 2uxoB-4ovdA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovd PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 407
ASN A 318
LEU A 320
MET A 418
ILE A 314
 None
 1.02A 2uxoB-4ovdA:
undetectable		 2uxoB-4ovdA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkv LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		5 LEU A 514
LEU A 437
VAL A 486
LEU A 293
ILE A 427
 None
 1.18A 2uxoB-4pkvA:
undetectable		 2uxoB-4pkvA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00266
(Aminotran_5) 		5 LEU A 235
LEU A 182
VAL A 212
CYH A 141
ILE A 198
 None
 1.16A 2uxoB-4q76A:
undetectable		 2uxoB-4q76A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Mycolicibacterium
smegmatis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 LEU A 542
VAL A 143
LEU A 151
ILE A 483
ILE A 211
 None
 1.11A 2uxoB-4rmfA:
undetectable		 2uxoB-4rmfA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4url DNA TOPOISOMERASE
IV, B SUBUNIT

(Staphylococcus
aureus) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 LEU A 346
LEU A 336
ILE A 227
VAL A 256
ILE A 254
 None
 1.09A 2uxoB-4urlA:
undetectable		 2uxoB-4urlA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Francisella
tularensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A 274
VAL A 156
ILE A 291
VAL A 153
ILE A 255
 None
 1.17A 2uxoB-4wojA:
undetectable		 2uxoB-4wojA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B

(Anopheles
gambiae) 		PF13855
(LRR_8) 		5 LEU A 274
ASN A 323
ILE A 237
VAL A 284
ILE A 304
 None
None
PO4  A1003 (-4.8A)
None
None
 1.13A 2uxoB-4xgoA:
undetectable		 2uxoB-4xgoA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhp PARM HYBRID FUSION
PROTEIN

(Bacillus
thuringiensis) 		no annotation 5 LEU A  73
LEU A  11
ILE A 128
VAL A 177
ILE A 189
 None
 1.16A 2uxoB-4xhpA:
undetectable		 2uxoB-4xhpA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 LEU A1175
VAL A1025
LEU A 495
VAL A 984
ILE A 985
 None
 1.13A 2uxoB-5a22A:
undetectable		 2uxoB-5a22A:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ch6 FRIGIDA

(Vitis vinifera) 		PF07899
(Frigida) 		5 LEU A 188
LEU A 148
VAL A 144
LEU A 134
CYH A 161
 None
 0.86A 2uxoB-5ch6A:
undetectable		 2uxoB-5ch6A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 VAL A 213
LEU A 160
ILE A 236
VAL A 173
ILE A 171
 None
 1.12A 2uxoB-5eioA:
undetectable		 2uxoB-5eioA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq8 BT_2262
(UNCHARACTERISED
LIPOPROTEIN)

(Bacteroides
thetaiotaomicron) 		PF16403
(DUF5011)
PF16404
(DUF5012) 		5 LEU G 186
LEU G  95
ILE G 133
VAL G 210
ILE G 209
 None
 1.07A 2uxoB-5fq8G:
undetectable		 2uxoB-5fq8G:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 LEU A 331
LEU A  90
ILE A 245
VAL A  75
ILE A 177
 None
 1.06A 2uxoB-5gtmA:
undetectable		 2uxoB-5gtmA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE

(Mycobacterium
tuberculosis) 		PF02358
(Trehalose_PPase) 		5 LEU A 379
LEU A 152
LEU A 131
VAL A 350
ILE A 348
 None
 1.14A 2uxoB-5gvxA:
undetectable		 2uxoB-5gvxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqk PEPTIDASE, PUTATIVE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 LEU A 353
LEU A 328
ILE A 415
VAL A 386
ILE A 385
 None
 1.21A 2uxoB-5jqkA:
undetectable		 2uxoB-5jqkA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 122
VAL A 118
LEU A 144
MET A 132
ILE A 170
 None
 1.16A 2uxoB-5lohA:
undetectable		 2uxoB-5lohA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 5 LEU A 239
LEU A 232
VAL A 220
LEU A 167
VAL A 171
 None
 1.08A 2uxoB-5nn8A:
undetectable		 2uxoB-5nn8A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 5 LEU A 521
LEU A 428
ILE A 444
VAL A 502
ILE A 505
 None
 1.19A 2uxoB-5ovnA:
undetectable		 2uxoB-5ovnA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 516
LEU A 592
LEU A 541
ILE A 463
VAL A 511
 None
 1.18A 2uxoB-5tf0A:
undetectable		 2uxoB-5tf0A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 LEU A 267
LEU A 213
VAL A 262
VAL A  23
ILE A  26
 None
 1.11A 2uxoB-5u03A:
undetectable		 2uxoB-5u03A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE

(Pseudomonas
aeruginosa) 		PF03331
(LpxC) 		5 LEU A  66
LEU A  26
VAL A  93
LEU A 248
ILE A  37
 None
 1.22A 2uxoB-5u39A:
undetectable		 2uxoB-5u39A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Pseudomonas
syringae) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 LEU A 152
LEU A  96
VAL A  94
CYH A 157
VAL A 139
 None
 1.12A 2uxoB-5u5gA:
1.5		 2uxoB-5u5gA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uos METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN

(Homo sapiens) 		PF16690
(MMACHC) 		5 LEU A  51
LEU A 166
VAL A 164
LEU A  53
VAL A  90
 None
 1.19A 2uxoB-5uosA:
undetectable		 2uxoB-5uosA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi6 HISTONE DEACETYLASE
8

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 LEU A 264
VAL A 175
LEU A 318
ILE A 243
ILE A 291
 None
 1.22A 2uxoB-5vi6A:
undetectable		 2uxoB-5vi6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w25 ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Mycobacterium
tuberculosis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 LEU A 545
VAL A 146
LEU A 154
ILE A 486
ILE A 214
 None
 1.12A 2uxoB-5w25A:
undetectable		 2uxoB-5w25A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1

(Streptococcus
pyogenes) 		PF13395
(HNH_4)
PF16592
(Cas9_REC)
PF16593
(Cas9-BH)
PF16595
(Cas9_PI) 		5 LEU A 153
LEU A 101
LEU A 142
ILE A  79
ILE A 135
 None
A  B  47 ( 3.6A)
None
A  B  48 ( 4.4A)
A  B  46 ( 3.5A)
 1.20A 2uxoB-5xblA:
3.8		 2uxoB-5xblA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		5 ASN A 421
LEU A 431
MET A 442
VAL A 440
ILE A 428
 None
 1.16A 2uxoB-5xgsA:
undetectable		 2uxoB-5xgsA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14

(Saccharomyces
cerevisiae) 		PF00782
(DSPc)
PF14671
(DSPn) 		5 LEU A 247
LEU A 356
ILE A 242
VAL A 223
ILE A 279
 None
 1.06A 2uxoB-5xw5A:
undetectable		 2uxoB-5xw5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6f FLAGELLAR BRAKE
PROTEIN YCGR

(Escherichia
coli) 		no annotation 5 LEU A 209
LEU A 139
MET A 176
VAL A 174
ILE A 172
 None
 1.20A 2uxoB-5y6fA:
undetectable		 2uxoB-5y6fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6g FLAGELLAR BRAKE
PROTEIN YCGR

(Escherichia
coli) 		no annotation 5 LEU A 209
LEU A 139
MET A 176
VAL A 174
ILE A 172
 None
 1.04A 2uxoB-5y6gA:
undetectable		 2uxoB-5y6gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybw ASPARTATE RACEMASE

(Scapharca
broughtonii) 		no annotation 5 LEU A 213
VAL A 187
LEU A 176
ILE A 258
ILE A 171
 None
 0.97A 2uxoB-5ybwA:
undetectable		 2uxoB-5ybwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 5 LEU A 457
LEU A 639
VAL A 637
LEU A 750
ILE A 735
 None
 1.06A 2uxoB-6aunA:
undetectable		 2uxoB-6aunA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S25E
RIBOSOMAL PROTEIN S7

(Leishmania
donovani) 		no annotation 5 LEU H 159
LEU H  89
LEU H  78
ILE a  64
VAL a 100
 None
None
U  11874 ( 4.6A)
None
None
 1.18A 2uxoB-6az1H:
undetectable		 2uxoB-6az1H:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dcs STAGE III
SPORULATION PROTEIN
AF

(Bacillus
subtilis) 		no annotation 5 LEU A 103
LEU A 123
MET A 197
VAL A 195
ILE A 193
 None
 0.96A 2uxoB-6dcsA:
undetectable		 2uxoB-6dcsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 5 LEU A  86
CYH A 252
ILE A 206
VAL A 285
ILE A 283
 None
 1.18A 2uxoB-6em0A:
0.9		 2uxoB-6em0A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo2 TRANSCRIPTIONAL
REGULATORY PROTEIN
RCSB

(Salmonella
enterica) 		no annotation 5 LEU A  81
LEU A 120
LEU A  45
ILE A  19
VAL A  31
 None
 1.22A 2uxoB-6eo2A:
2.1		 2uxoB-6eo2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 1,
MITOCHONDRIAL

(Mus musculus) 		no annotation 5 LEU F 306
LEU F 322
CYH F 312
VAL F 334
ILE F 335
 None
 1.21A 2uxoB-6g2jF:
undetectable		 2uxoB-6g2jF:
17.17