SIMILAR PATTERNS OF AMINO ACIDS FOR 2UVN_A_ECNA1409_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		5 PRO A 126
GLY A 294
GLY A 295
THR A 257
LEU A  31
 None
None
ZN  A 501 ( 4.1A)
None
None
 1.18A 2uvnA-1c3rA:
0.0		 2uvnA-1c3rA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		5 ASP A 145
THR A 118
GLY A 117
GLY A 116
LEU A  22
 None
NAP  A 191 (-4.4A)
NAP  A 191 (-3.3A)
NAP  A 191 ( 4.2A)
NAP  A 191 ( 4.7A)
 0.99A 2uvnA-1dr6A:
undetectable		 2uvnA-1dr6A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		5 ASP A 145
THR A 118
GLY A 117
GLY A 116
THR A  56
 None
NAP  A 191 (-4.4A)
NAP  A 191 (-3.3A)
NAP  A 191 ( 4.2A)
NAP  A 191 (-3.5A)
 0.83A 2uvnA-1dr6A:
undetectable		 2uvnA-1dr6A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy1 HEPARIN-BINDING
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 MET A  91
MET A  76
GLY A  28
GLY A  27
LEU A  95
 None
 0.95A 2uvnA-1fy1A:
undetectable		 2uvnA-1fy1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy1 HEPARIN-BINDING
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 MET A  91
MET A  76
THR A  38
GLY A  28
LEU A  95
 None
 1.07A 2uvnA-1fy1A:
undetectable		 2uvnA-1fy1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 MET A 183
THR A 189
GLY A 158
THR A 150
LEU A 574
 None
 1.17A 2uvnA-1g8kA:
0.0		 2uvnA-1g8kA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		5 THR A 297
THR A 303
GLY A 302
GLY A 301
LEU A 413
 None
 1.16A 2uvnA-1hn0A:
0.0		 2uvnA-1hn0A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iok CHAPERONIN 60

(Paracoccus
denitrificans) 		PF00118
(Cpn60_TCP1) 		5 LEU A 247
ASP A 217
THR A 296
GLY A 318
GLY A 298
 None
 1.06A 2uvnA-1iokA:
0.0		 2uvnA-1iokA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jg5 GTP CYCLOHYDROLASE I
FEEDBACK REGULATORY
PROTEIN

(Rattus
norvegicus) 		PF06399
(GFRP) 		5 LEU A  59
PRO A  52
THR A  16
THR A   7
LEU A  80
 None
None
None
K  A1504 (-3.8A)
None
 1.15A 2uvnA-1jg5A:
undetectable		 2uvnA-1jg5A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jrj EXENDIN-4

(Heloderma
suspectum) 		PF00123
(Hormone_2) 		5 LEU A  21
PRO A  38
PRO A  37
GLY A  30
GLY A  29
 None
 1.17A 2uvnA-1jrjA:
undetectable		 2uvnA-1jrjA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq9 ACTVA-ORF6
MONOOXYGENASE

(Streptomyces
coelicolor) 		PF03992
(ABM) 		5 LEU A  28
THR A  33
GLY A  34
GLY A  35
LEU A  92
 None
 1.14A 2uvnA-1lq9A:
undetectable		 2uvnA-1lq9A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		5 LEU A  77
ASP A 286
GLY A 228
GLY A 229
LEU A  82
 None
 1.21A 2uvnA-1mt5A:
0.0		 2uvnA-1mt5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 LEU A 179
GLY A 202
GLY A 203
THR A 206
LEU A 181
 None
 1.11A 2uvnA-1rzvA:
undetectable		 2uvnA-1rzvA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		5 PRO A  81
THR A  70
GLY A  47
GLY A  48
THR A  51
 None
None
None
NAP  A3075 (-3.4A)
None
 1.21A 2uvnA-1suwA:
undetectable		 2uvnA-1suwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5j HYPOTHETICAL PROTEIN
MJ1187

(Methanocaldococcus
jannaschii) 		PF03747
(ADP_ribosyl_GH) 		5 LEU A  36
THR A  29
GLY A 251
GLY A 252
THR A 254
 None
 0.91A 2uvnA-1t5jA:
undetectable		 2uvnA-1t5jA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt4 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF04107
(GCS2) 		6 LEU A 358
PRO A 101
MET A 171
THR A  99
GLY A  97
LEU A 361
 None
 1.46A 2uvnA-1tt4A:
undetectable		 2uvnA-1tt4A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2e 2-HYDROXY-6-KETONONA
-2,4-DIENEDIOIC ACID
HYDROLASE

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		5 LEU A 247
ASP A 241
THR A 137
GLY A 136
LEU A 255
 None
 1.19A 2uvnA-1u2eA:
undetectable		 2uvnA-1u2eA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		5 LEU A 136
ASP A  11
GLY A 178
GLY A 354
THR A 358
 None
None
None
PO4  A 500 (-3.1A)
None
 1.17A 2uvnA-1vlpA:
undetectable		 2uvnA-1vlpA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE

(Escherichia
coli) 		PF00171
(Aldedh) 		5 LEU A 328
GLY A 350
GLY A 349
THR A 363
LEU A 322
 None
 1.14A 2uvnA-1wnbA:
undetectable		 2uvnA-1wnbA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B

(Homo sapiens) 		PF00899
(ThiF)
PF14732
(UAE_UbL)
PF16195
(UBA2_C) 		5 LEU B 517
ASP B 520
THR B 488
GLY B 487
GLY B 485
 None
 1.21A 2uvnA-1y8qB:
undetectable		 2uvnA-1y8qB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybd URIDYLATE KINASE

(Neisseria
meningitidis) 		PF00696
(AA_kinase) 		5 LEU A  13
ASP A 146
MET A 156
THR A 138
GLY A 137
 None
GOL  A 250 ( 4.4A)
None
None
None
 1.18A 2uvnA-1ybdA:
undetectable		 2uvnA-1ybdA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys2 LIPASE

(Burkholderia
cepacia) 		PF00561
(Abhydrolase_1) 		5 PRO X 113
THR X 109
GLY X  90
THR X  92
LEU X 167
 None
None
None
None
2HS  X 600 ( 4.5A)
 1.21A 2uvnA-1ys2X:
undetectable		 2uvnA-1ys2X:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8i THREONINE ASPARTASE
1

(Homo sapiens) 		PF01112
(Asparaginase_2) 		5 THR A 290
GLY A 342
GLY A 341
THR A 373
LEU A 319
 None
 1.05A 2uvnA-2a8iA:
undetectable		 2uvnA-2a8iA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az4 HYPOTHETICAL PROTEIN
EF2904

(Enterococcus
faecalis) 		PF12706
(Lactamase_B_2) 		5 LEU A 104
THR A  38
GLY A  37
GLY A  20
LEU A 110
 None
 1.12A 2uvnA-2az4A:
undetectable		 2uvnA-2az4A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkn 3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Pseudomonas sp.
B-0831) 		PF13561
(adh_short_C2) 		5 ASP A  32
THR A  50
GLY A  47
GLY A  46
THR A  44
 NAI  A4000 (-2.7A)
None
None
None
None
 0.99A 2uvnA-2dknA:
undetectable		 2uvnA-2dknA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6u ORNITHINE
CARBAMOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A  20
PRO A  13
THR A 171
THR A 201
GLY A 173
 None
 1.02A 2uvnA-2i6uA:
undetectable		 2uvnA-2i6uA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Porphyromonas
gingivalis) 		PF04095
(NAPRTase) 		5 LEU A 124
ASP A   9
GLY A 166
GLY A 331
THR A 335
 None
 1.12A 2uvnA-2im5A:
undetectable		 2uvnA-2im5A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjx URIDYLATE KINASE

(Bacillus
anthracis) 		PF00696
(AA_kinase) 		5 LEU A   8
ASP A 142
GLY A 133
GLY A 132
THR A  79
 None
 1.21A 2uvnA-2jjxA:
undetectable		 2uvnA-2jjxA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjx URIDYLATE KINASE

(Bacillus
anthracis) 		PF00696
(AA_kinase) 		5 LEU A   8
ASP A 142
MET A 152
GLY A 133
GLY A 132
 None
 1.20A 2uvnA-2jjxA:
undetectable		 2uvnA-2jjxA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kho HEAT SHOCK PROTEIN
70

(Escherichia
coli) 		PF00012
(HSP70) 		5 ASP A  85
THR A 199
GLY A 198
GLY A 197
THR A  12
 None
 1.20A 2uvnA-2khoA:
undetectable		 2uvnA-2khoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii) 		PF01095
(Pectinesterase) 		5 LEU A 180
ASP A 199
THR A 289
GLY A 243
THR A 236
 None
 1.17A 2uvnA-2ntbA:
undetectable		 2uvnA-2ntbA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw8 EUGENOL SYNTHASE 1

(Ocimum
basilicum) 		PF05368
(NmrA) 		5 LEU A  54
THR A  16
GLY A  15
GLY A  20
LEU A  28
 None
NAP  A 401 (-2.8A)
None
None
None
 1.21A 2uvnA-2qw8A:
undetectable		 2uvnA-2qw8A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9p REPLICATION PROTEIN
E1

(Deltapapillomavirus
4) 		PF00519
(PPV_E1_C) 		5 PRO A 517
PRO A 516
GLY A 452
GLY A 451
LEU A 420
 None
 1.12A 2uvnA-2v9pA:
undetectable		 2uvnA-2v9pA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmj DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
xylosoxidans) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 PRO A 260
THR A 253
GLY A 275
THR A 125
LEU A 148
 None
 1.19A 2uvnA-2vmjA:
undetectable		 2uvnA-2vmjA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ASP A 644
PRO A  80
THR A 214
GLY A 211
THR A 241
 None
None
MGD  A1766 (-4.1A)
None
None
 1.22A 2uvnA-2vpwA:
undetectable		 2uvnA-2vpwA:
19.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wgy CYTOCHROME P450 130

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 LEU A  71
THR A 239
GLY A 244
THR A 247
LEU A 293
 HEM  A 450 ( 4.3A)
None
HEM  A 450 (-3.4A)
HEM  A 450 (-3.6A)
HEM  A 450 (-4.4A)
 0.71A 2uvnA-2wgyA:
59.6		 2uvnA-2wgyA:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wgy CYTOCHROME P450 130

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 MET A  89
THR A 239
GLY A 244
THR A 247
LEU A 293
 HEM  A 450 (-4.3A)
None
HEM  A 450 (-3.4A)
HEM  A 450 (-3.6A)
HEM  A 450 (-4.4A)
 1.18A 2uvnA-2wgyA:
59.6		 2uvnA-2wgyA:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wgy CYTOCHROME P450 130

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 MET A  89
THR A 239
THR A 242
GLY A 244
THR A 247
 HEM  A 450 (-4.3A)
None
None
HEM  A 450 (-3.4A)
HEM  A 450 (-3.6A)
 1.02A 2uvnA-2wgyA:
59.6		 2uvnA-2wgyA:
99.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 ASP A1278
PRO A 702
THR A 700
GLY A 730
GLY A 723
 None
 1.19A 2uvnA-3ecqA:
undetectable		 2uvnA-3ecqA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ASP B 834
GLY B 807
GLY B 806
THR B 839
LEU B 792
 None
 0.99A 2uvnA-3hkzB:
undetectable		 2uvnA-3hkzB:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl0 MALEYLACETATE
REDUCTASE

(Agrobacterium
fabrum) 		PF00465
(Fe-ADH) 		5 ASP A  46
THR A  97
GLY A  94
GLY A  95
THR A 118
 None
None
NAD  A 402 (-3.3A)
NAD  A 402 (-3.2A)
NAD  A 402 (-2.8A)
 1.13A 2uvnA-3hl0A:
undetectable		 2uvnA-3hl0A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5t AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00202
(Aminotran_3) 		5 LEU A 128
THR A 285
GLY A 299
GLY A 298
THR A 117
 None
 0.96A 2uvnA-3i5tA:
undetectable		 2uvnA-3i5tA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihj ALANINE
AMINOTRANSFERASE 2

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 PRO A 378
PRO A 377
THR A 185
GLY A 351
THR A 339
 None
 1.21A 2uvnA-3ihjA:
undetectable		 2uvnA-3ihjA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwp TRANSCRIPTIONAL
REGULATORY PROTEIN
SIR2 HOMOLOGUE

(Plasmodium
falciparum) 		PF02146
(SIR2) 		5 THR A  27
THR A 200
GLY A 199
GLY A  30
LEU A 247
 None
AMP  A 266 (-4.4A)
AMP  A 266 (-3.5A)
AMP  A 266 (-3.2A)
None
 1.05A 2uvnA-3jwpA:
undetectable		 2uvnA-3jwpA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus) 		PF03372
(Exo_endo_phos) 		5 LEU A 208
ASP A 251
GLY A 192
GLY A 193
THR A 149
 None
 1.20A 2uvnA-3k55A:
undetectable		 2uvnA-3k55A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksw STEROL 14-ALPHA
DEMETHYLASE

(Trypanosoma
cruzi) 		PF00067
(p450) 		5 LEU A 385
PRO A 354
PRO A 355
GLY A 414
GLY A 416
 None
None
None
None
HEM  A 488 ( 4.3A)
 1.15A 2uvnA-3kswA:
21.5		 2uvnA-3kswA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
SUMO-ACTIVATING
ENZYME SUBUNIT 2

(Homo sapiens) 		PF00899
(ThiF)
PF14732
(UAE_UbL) 		5 LEU A 318
ASP A 322
GLY A 308
THR B 389
LEU A  34
 None
 1.14A 2uvnA-3kydA:
undetectable		 2uvnA-3kydA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		5 LEU A 384
PRO A 353
PRO A 354
GLY A 414
GLY A 416
 None
None
HEM  A 481 ( 4.6A)
None
HEM  A 481 (-3.7A)
 1.19A 2uvnA-3l4dA:
26.6		 2uvnA-3l4dA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 LEU A 280
ASP A 271
THR A 291
GLY A 290
GLY A 289
 None
 1.18A 2uvnA-3mcxA:
undetectable		 2uvnA-3mcxA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o65 PUTATIVE
ATAXIN-3-LIKE
PROTEIN

(Homo sapiens) 		PF02099
(Josephin) 		5 LEU A  24
ASP A 176
PRO A 171
GLY A 168
LEU A  23
 None
 1.12A 2uvnA-3o65A:
undetectable		 2uvnA-3o65A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		5 LEU A 578
PRO A 616
THR A 600
GLY A 597
LEU A 580
 None
 1.22A 2uvnA-3okyA:
undetectable		 2uvnA-3okyA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		5 LEU A 108
THR A 213
GLY A 212
GLY A  52
LEU A  96
 None
A2N  A1000 (-3.8A)
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
 1.04A 2uvnA-3pkjA:
undetectable		 2uvnA-3pkjA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 LEU A 208
MET A1006
THR A1152
THR A1155
GLY A1156
 None
 1.15A 2uvnA-3qakA:
undetectable		 2uvnA-3qakA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1z ENDONUCLEASE
BSE634IR

(Geobacillus
stearothermophilus) 		PF07832
(Bse634I) 		5 PRO A  26
THR A  74
THR A  77
GLY A  76
THR A 199
 None
 1.11A 2uvnA-3v1zA:
undetectable		 2uvnA-3v1zA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc7 PUTATIVE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 LEU A 123
THR A  37
GLY A  14
GLY A  15
LEU A  85
 None
 1.12A 2uvnA-3vc7A:
undetectable		 2uvnA-3vc7A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 LEU A 433
ASP A 440
THR A 169
GLY A  86
GLY A  85
 None
None
None
FAD  A 702 (-4.3A)
FAD  A 702 ( 3.3A)
 1.21A 2uvnA-3vrbA:
undetectable		 2uvnA-3vrbA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(Aquifex
aeolicus;
synthetic
construct) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		5 ASP A  46
GLY A 162
GLY A 161
THR A 135
LEU A 198
 SO4  A1001 ( 4.7A)
None
None
None
None
 0.97A 2uvnA-3wfpA:
undetectable		 2uvnA-3wfpA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		5 LEU A 108
THR A 213
GLY A 212
GLY A  52
LEU A  96
 None
APR  A1296 (-3.7A)
APR  A1296 (-3.6A)
APR  A1296 (-3.3A)
None
 1.02A 2uvnA-3zg6A:
undetectable		 2uvnA-3zg6A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7k SAM-DEPENDENT
METHYLTRANSFERASES

(Streptomyces
davaonensis) 		PF00891
(Methyltransf_2) 		5 LEU A  92
ASP A  40
THR A 105
THR A 106
GLY A 103
 None
 1.21A 2uvnA-4d7kA:
undetectable		 2uvnA-4d7kA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00701
(DHDPS) 		5 LEU A 308
PRO A 301
THR A 108
GLY A 109
GLY A 105
 None
 1.12A 2uvnA-4dppA:
undetectable		 2uvnA-4dppA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzr PROTEIN-(GLUTAMINE-N
5)
METHYLTRANSFERASE,
RELEASE
FACTOR-SPECIFIC

(Alicyclobacillus
acidocaldarius) 		PF05175
(MTS) 		5 PRO A 207
PRO A 208
THR A 137
GLY A 136
LEU A 261
 None
 1.14A 2uvnA-4dzrA:
undetectable		 2uvnA-4dzrA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY

(Burkholderia
thailandensis) 		PF02636
(Methyltransf_28) 		5 LEU A 133
GLY A 187
GLY A 270
THR A 116
LEU A 137
 None
 1.13A 2uvnA-4f3nA:
undetectable		 2uvnA-4f3nA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		5 LEU A 385
PRO A 354
PRO A 355
GLY A 414
GLY A 416
 None
None
HEM  A 501 ( 4.8A)
None
HEM  A 501 (-4.0A)
 1.20A 2uvnA-4g3jA:
26.7		 2uvnA-4g3jA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6q PUTATIVE
UNCHARACTERIZED
PROTEIN

(Kribbella
flavida) 		PF12840
(HTH_20) 		5 ASP A  45
PRO A  20
GLY A 112
GLY A 111
LEU A  28
 None
 1.12A 2uvnA-4g6qA:
undetectable		 2uvnA-4g6qA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbq MUCOSAL ADDRESSIN
CELL ADHESION
MOLECULE 1

(Homo sapiens) 		PF09085
(Adhes-Ig_like) 		5 LEU A 172
PRO A 177
PRO A 178
GLY A 132
GLY A 133
 None
 0.88A 2uvnA-4hbqA:
undetectable		 2uvnA-4hbqA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE

(Vitis vinifera) 		PF00701
(DHDPS) 		5 LEU A 270
PRO A 263
THR A  70
GLY A  71
GLY A  67
 None
None
KPI  A 184 ( 3.8A)
None
None
 1.12A 2uvnA-4hnnA:
undetectable		 2uvnA-4hnnA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		6 MET A  88
THR A  77
THR A  66
GLY A  65
GLY A 301
LEU A 141
 None
None
None
None
None
BGC  A 942 ( 3.9A)
 1.39A 2uvnA-4iigA:
undetectable		 2uvnA-4iigA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ita SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Synechococcus
sp. PCC 7002) 		PF00171
(Aldedh) 		5 LEU A 310
GLY A 331
GLY A 330
THR A 344
LEU A 304
 None
 1.11A 2uvnA-4itaA:
undetectable		 2uvnA-4itaA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00012
(HSP70) 		5 ASP A 136
THR A 249
GLY A 248
GLY A 247
THR A  63
 None
NA  A 501 ( 4.6A)
None
None
None
 1.17A 2uvnA-4kboA:
undetectable		 2uvnA-4kboA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 PRO A 164
THR A 125
GLY A 126
THR B 221
LEU A 141
 None
None
None
FAD  B 301 ( 4.2A)
None
 1.16A 2uvnA-4kpuA:
undetectable		 2uvnA-4kpuA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Streptococcus
pneumoniae) 		PF01070
(FMN_dh) 		5 LEU A  95
ASP A 100
THR A 116
THR A  88
GLY A  89
 None
None
None
None
FNR  A 404 (-3.5A)
 0.98A 2uvnA-4n02A:
undetectable		 2uvnA-4n02A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE

(Homo sapiens) 		PF01112
(Asparaginase_2) 		5 LEU A 233
THR A 218
GLY A 264
GLY A 263
THR A 279
 None
 1.09A 2uvnA-4o0eA:
undetectable		 2uvnA-4o0eA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o48 UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF01112
(Asparaginase_2) 		5 LEU A 233
THR A 218
GLY A 265
GLY A 264
THR A 280
 None
 1.08A 2uvnA-4o48A:
undetectable		 2uvnA-4o48A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		5 LEU A 393
ASP A 418
THR A 446
GLY A 447
GLY A 452
 None
 1.17A 2uvnA-4oflA:
undetectable		 2uvnA-4oflA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otu GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		5 LEU B 459
THR B 483
GLY B 482
GLY B 481
THR B 399
 None
None
GLU  B 602 (-3.1A)
GLU  B 602 ( 4.2A)
GLU  B 602 (-2.7A)
 1.16A 2uvnA-4otuB:
undetectable		 2uvnA-4otuB:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ric FANCONI-ASSOCIATED
NUCLEASE 1

(Homo sapiens) 		PF08774
(VRR_NUC) 		5 PRO A 701
THR A 667
GLY A 663
THR A 661
LEU A 655
 None
 1.14A 2uvnA-4ricA:
undetectable		 2uvnA-4ricA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2i ESTERASE/LIPASE

(Thalassospira
sp. GB04J01) 		PF07859
(Abhydrolase_3) 		5 LEU A  99
GLY A 160
GLY A 161
THR A 164
LEU A 103
 None
 1.16A 2uvnA-4v2iA:
undetectable		 2uvnA-4v2iA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye7 ORF22 SIMILAR TO
XCGV ORF19

(Cydia pomonella
granulovirus) 		PF04512
(Baculo_PEP_N) 		5 ASP A  47
PRO A  50
GLY A  84
THR A  86
LEU A  36
 None
 1.01A 2uvnA-4ye7A:
undetectable		 2uvnA-4ye7A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A  32
THR A 345
GLY A 348
THR A 350
LEU A  28
 None
 1.08A 2uvnA-5bp1A:
undetectable		 2uvnA-5bp1A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		5 LEU A  81
ASP A 504
GLY A 131
THR A 197
LEU A 139
 None
 1.16A 2uvnA-5bp8A:
undetectable		 2uvnA-5bp8A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cr9 ABC-TYPE
FE3+-HYDROXAMATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Saccharomonospora
viridis) 		PF01497
(Peripla_BP_2) 		5 LEU A 131
PRO A  58
PRO A  57
GLY A 178
LEU A 133
 None
 0.91A 2uvnA-5cr9A:
undetectable		 2uvnA-5cr9A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 LEU A 165
ASP A  99
GLY A 233
GLY A 235
LEU A 140
 None
 1.17A 2uvnA-5dmhA:
undetectable		 2uvnA-5dmhA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez7 FLAVOENZYME PA4991

(Pseudomonas
aeruginosa) 		PF01266
(DAO) 		5 LEU A 171
PRO A 379
PRO A 380
GLY A  42
LEU A  34
 None
None
None
FAD  A 401 ( 4.6A)
None
 0.76A 2uvnA-5ez7A:
undetectable		 2uvnA-5ez7A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbu PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N) 		5 LEU A 387
PRO A 392
GLY A 821
GLY A 820
THR A 824
 5WP  A 901 (-4.3A)
None
None
None
None
 1.13A 2uvnA-5fbuA:
undetectable		 2uvnA-5fbuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		5 LEU A 265
PRO A 215
THR A  59
GLY A  31
GLY A  32
 None
 1.18A 2uvnA-5fyaA:
undetectable		 2uvnA-5fyaA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gli ENDOTHELIN RECEPTOR
SUBTYPE-B

(Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 LEU A 315
MET A1006
THR A1109
THR A1112
GLY A1113
 None
 0.96A 2uvnA-5gliA:
undetectable		 2uvnA-5gliA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))

(Thermoplasma
acidophilum) 		PF00171
(Aldedh) 		5 LEU A 327
GLY A 348
GLY A 347
THR A 366
LEU A 321
 None
 1.20A 2uvnA-5izdA:
undetectable		 2uvnA-5izdA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lvy ADHESIN PROTEIN

(Escherichia
coli) 		no annotation 5 THR A  77
THR A  78
GLY A  89
GLY A  90
LEU A  38
 None
 1.19A 2uvnA-5lvyA:
undetectable		 2uvnA-5lvyA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 5 PRO A 425
THR A 370
GLY A 369
GLY A 368
THR A 406
 None
 1.02A 2uvnA-5ny0A:
undetectable		 2uvnA-5ny0A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 5 LEU A 217
MET A 210
THR A 132
GLY A 135
LEU A 259
 None
 1.07A 2uvnA-5oynA:
undetectable		 2uvnA-5oynA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui3 DIHYDRODIPICOLINATE
SYNTHASE

(Chlamydomonas
reinhardtii) 		no annotation 5 LEU D 268
PRO D 261
THR D  68
GLY D  69
GLY D  65
 None
None
AKG  D 401 (-3.6A)
None
None
 1.13A 2uvnA-5ui3D:
undetectable		 2uvnA-5ui3D:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uib OXIDOREDUCTASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF01408
(GFO_IDH_MocA) 		5 ASP A 118
PRO A 120
MET A 122
THR A 312
GLY A 310
 None
 0.97A 2uvnA-5uibA:
undetectable		 2uvnA-5uibA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uu1 SERINE/THREONINE-PRO
TEIN KINASE VRK2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 124
MET A 121
GLY A  38
GLY A  39
LEU A 173
 7DZ  A 401 (-4.1A)
7DZ  A 401 (-4.3A)
7DZ  A 401 (-3.3A)
None
None
 0.83A 2uvnA-5uu1A:
undetectable		 2uvnA-5uu1A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4q GAMMA-GLUTAMYLTRANSP
EPTIDASE 1 LIGHT
CHAIN

(Homo sapiens) 		PF01019
(G_glu_transpept) 		6 LEU B 450
ASP B 422
THR B 475
GLY B 474
GLY B 473
THR B 381
 None
None
None
8WY  B1102 (-3.6A)
8WY  B1102 (-3.7A)
8WY  B1102 (-2.4A)
 1.40A 2uvnA-5v4qB:
undetectable		 2uvnA-5v4qB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5) 		PF01801
(Cytomega_gL) 		5 LEU B 123
ASP B 117
THR B 153
GLY B 161
LEU B  82
 None
 1.20A 2uvnA-5vocB:
undetectable		 2uvnA-5vocB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpq BETA-LACTAMASE

(Paraburkholderia
phymatum) 		PF13354
(Beta-lactamase2) 		5 PRO A 163
THR A 255
THR A 233
GLY A 232
THR A 262
 None
 1.02A 2uvnA-5vpqA:
undetectable		 2uvnA-5vpqA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw3 O-ACETYLSERINE LYASE

(Bacillus
anthracis) 		PF00291
(PALP) 		5 PRO A 137
THR A  66
GLY A  65
GLY A  64
THR A  62
 None
 1.08A 2uvnA-5xw3A:
undetectable		 2uvnA-5xw3A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae) 		no annotation 5 LEU A  86
PRO A  83
THR A  80
GLY A  72
GLY A  73
 None
 1.18A 2uvnA-6brdA:
undetectable		 2uvnA-6brdA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gb1 PEPTIDE 11

(synthetic
construct) 		no annotation 5 LEU B  21
PRO B  38
PRO B  37
GLY B  30
GLY B  29
 None
HEZ  B 101 (-3.2A)
HEZ  B 101 (-4.6A)
None
AIB  B  27 ( 4.5A)
 1.02A 2uvnA-6gb1B:
undetectable		 2uvnA-6gb1B:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdz EXENDIN-4

(Heloderma
suspectum) 		no annotation 5 LEU A  21
PRO A  38
PRO A  37
GLY A  30
GLY A  29
 None
None
None
None
AIB  A  27 ( 4.1A)
 1.20A 2uvnA-6gdzA:
undetectable		 2uvnA-6gdzA:
7.02