SIMILAR PATTERNS OF AMINO ACIDS FOR 2TSR_B_D16B409_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		5 ASP A 303
LEU A 306
GLY A 302
PHE A 301
TYR A  14
 None
 1.15A 2tsrB-1am5A:
undetectable		 2tsrB-1am5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aol GP70

(Murine leukemia
virus) 		PF00429
(TLV_coat) 		4 ARG A 225
ILE A 224
GLY A 195
PHE A 191
 None
 0.91A 2tsrB-1aolA:
0.0		 2tsrB-1aolA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b12 SIGNAL PEPTIDASE I

(Escherichia
coli) 		PF00717
(Peptidase_S24)
PF10502
(Peptidase_S26) 		4 ARG A 295
ILE A 130
ASP A 280
GLY A 272
 None
 0.87A 2tsrB-1b12A:
0.0		 2tsrB-1b12A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)

(Hordeum vulgare) 		PF01373
(Glyco_hydro_14) 		4 ILE A 392
LEU A 411
GLY A 413
PHE A 414
 None
 0.93A 2tsrB-1b1yA:
0.0		 2tsrB-1b1yA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bsf THYMIDYLATE SYNTHASE
A

(Bacillus
subtilis) 		PF00303
(Thymidylat_synt) 		4 ASP A 184
GLY A 188
PHE A 191
TYR A 224
 None
 0.42A 2tsrB-1bsfA:
31.1		 2tsrB-1bsfA:
35.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bsf THYMIDYLATE SYNTHASE
A

(Bacillus
subtilis) 		PF00303
(Thymidylat_synt) 		4 ILE A  93
ASP A 184
GLY A 188
TYR A 224
 None
 0.69A 2tsrB-1bsfA:
31.1		 2tsrB-1bsfA:
35.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0a ASPARTYL TRNA
SYNTHETASE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 ASP A 536
LEU A 535
GLY A 534
PHE A 533
 None
None
AMO  A 831 (-3.4A)
None
 0.79A 2tsrB-1c0aA:
0.0		 2tsrB-1c0aA:
18.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ci7 PROTEIN (THYMIDYLATE
SYNTHASE)

(Pneumocystis
carinii) 		PF00303
(Thymidylat_synt) 		6 ILE A  86
ASP A 202
LEU A 205
GLY A 206
PHE A 209
TYR A 242
 CB3  A 768 (-3.6A)
CB3  A 768 ( 3.6A)
CB3  A 768 ( 4.4A)
UMP  A 767 (-3.7A)
CB3  A 768 (-3.6A)
CB3  A 768 ( 4.7A)
 0.55A 2tsrB-1ci7A:
41.6		 2tsrB-1ci7A:
58.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ci7 PROTEIN (THYMIDYLATE
SYNTHASE)

(Pneumocystis
carinii) 		PF00303
(Thymidylat_synt) 		5 ILE A  86
TRP A  87
ASP A 202
PHE A 209
TYR A 242
 CB3  A 768 (-3.6A)
None
CB3  A 768 ( 3.6A)
CB3  A 768 (-3.6A)
CB3  A 768 ( 4.7A)
 0.79A 2tsrB-1ci7A:
41.6		 2tsrB-1ci7A:
58.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 176
ILE A 149
LEU A 141
GLY A 140
 TPO  A 183 ( 3.9A)
None
None
None
 0.78A 2tsrB-1cm8A:
undetectable		 2tsrB-1cm8A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cov COXSACKIEVIRUS COAT
PROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		4 ILE 3 114
LEU 3 104
GLY 3 101
PHE 3  95
 None
 0.85A 2tsrB-1cov3:
undetectable		 2tsrB-1cov3:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g38 MODIFICATION
METHYLASE TAQI

(Thermus
aquaticus) 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		4 ARG A 244
ILE A 243
TRP A 238
TYR A 140
 None
 0.91A 2tsrB-1g38A:
undetectable		 2tsrB-1g38A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g60 ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA

(Moraxella bovis) 		PF01555
(N6_N4_Mtase) 		4 TRP A  96
LEU A  86
PHE A  93
TYR A  54
 None
 0.79A 2tsrB-1g60A:
undetectable		 2tsrB-1g60A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g67 THIAMIN PHOSPHATE
SYNTHASE

(Bacillus
subtilis) 		PF02581
(TMP-TENI) 		5 ARG A  59
ILE A 186
ASP A 203
LEU A  26
GLY A 204
 POP  A2003 ( 3.9A)
ICP  A2001 ( 3.7A)
None
None
None
 1.49A 2tsrB-1g67A:
undetectable		 2tsrB-1g67A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ARG A 437
ASP A 323
LEU A 309
GLY A 308
 None
 0.94A 2tsrB-1gpeA:
undetectable		 2tsrB-1gpeA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF06470
(SMC_hinge) 		4 ILE A 524
LEU A 609
GLY A 610
PHE A 614
 None
 0.82A 2tsrB-1gxlA:
undetectable		 2tsrB-1gxlA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 ILE A 325
LEU A 301
GLY A 268
PHE A 334
 None
 0.85A 2tsrB-1hkkA:
undetectable		 2tsrB-1hkkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htw HI0065

(Haemophilus
influenzae) 		PF02367
(TsaE) 		4 ILE A  24
ASP A 126
LEU A 148
GLY A 149
 None
 0.92A 2tsrB-1htwA:
undetectable		 2tsrB-1htwA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv5 STROMELYSIN 3

(Mus musculus) 		PF00413
(Peptidase_M10) 		4 ILE A 159
LEU A 225
GLY A 222
PHE A 221
 None
 0.92A 2tsrB-1hv5A:
undetectable		 2tsrB-1hv5A:
20.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvy THYMIDYLATE SYNTHASE

(Homo sapiens) 		PF00303
(Thymidylat_synt) 		7 ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.51A 2tsrB-1hvyA:
44.9		 2tsrB-1hvyA:
92.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hze RIBOFLAVIN SYNTHASE
ALPHA CHAIN

(Escherichia
coli) 		PF00677
(Lum_binding) 		4 ILE A  70
ASP A  75
LEU A  73
GLY A  74
 RBF  A  98 ( 4.1A)
None
None
None
 0.96A 2tsrB-1hzeA:
undetectable		 2tsrB-1hzeA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		4 ILE A 137
LEU A  45
GLY A 114
TYR A  24
 None
 0.93A 2tsrB-1idjA:
undetectable		 2tsrB-1idjA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		5 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.13A 2tsrB-1izeA:
undetectable		 2tsrB-1izeA:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j3j BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00303
(Thymidylat_synt) 		5 ARG C 402
ASP C 513
LEU C 516
GLY C 517
TYR C 553
 None
UMP  C 611 (-4.9A)
None
UMP  C 611 (-3.5A)
UMP  C 611 (-4.9A)
 0.77A 2tsrB-1j3jC:
40.7		 2tsrB-1j3jC:
50.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j3j BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00303
(Thymidylat_synt) 		5 ARG C 402
ILE C 403
ASP C 513
GLY C 517
TYR C 553
 None
None
UMP  C 611 (-4.9A)
UMP  C 611 (-3.5A)
UMP  C 611 (-4.9A)
 1.11A 2tsrB-1j3jC:
40.7		 2tsrB-1j3jC:
50.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kr1 HEVAMINE A

(Hevea
brasiliensis) 		PF00704
(Glyco_hydro_18) 		4 TRP A 101
ASP A 120
LEU A 119
GLY A 121
 None
 0.95A 2tsrB-1kr1A:
undetectable		 2tsrB-1kr1A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Methanothermobacter
thermautotrophicus) 		PF00483
(NTP_transferase) 		4 ILE A  52
ASP A 108
LEU A 106
GLY A 107
 None
TYD  A3001 ( 2.9A)
TYD  A3001 (-3.4A)
TYD  A3001 (-4.1A)
 0.92A 2tsrB-1lvwA:
undetectable		 2tsrB-1lvwA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mf1 ADENYLOSUCCINATE
SYNTHETASE

(Mus musculus) 		PF00709
(Adenylsucc_synt) 		4 ARG A 431
ASP A 343
LEU A 344
GLY A 376
 None
 0.94A 2tsrB-1mf1A:
undetectable		 2tsrB-1mf1A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 ARG A 318
ILE A 316
LEU A 308
GLY A 313
 GCU  A 701 (-2.8A)
None
None
None
 0.92A 2tsrB-1mqqA:
undetectable		 2tsrB-1mqqA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		5 ARG A 366
ASP A 431
LEU A 435
GLY A 434
PHE A 381
 None
 1.04A 2tsrB-1pbyA:
undetectable		 2tsrB-1pbyA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pie GALACTOKINASE

(Lactococcus
lactis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 ILE A 196
ASP A 183
LEU A 182
PHE A 185
 None
PO4  A 401 ( 3.2A)
GLA  A 400 ( 4.3A)
None
 0.92A 2tsrB-1pieA:
undetectable		 2tsrB-1pieA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmj BETA-1,4-MANNANASE

(Caldicellulosiruptor
saccharolyticus) 		PF09212
(CBM27) 		4 ILE X 173
ASP X  61
GLY X 164
PHE X 103
 None
 0.95A 2tsrB-1pmjX:
undetectable		 2tsrB-1pmjX:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8r CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUSA

(Escherichia
coli) 		PF05866
(RusA) 		4 ARG A  58
ILE A  59
LEU A  82
PHE A  79
 None
 0.83A 2tsrB-1q8rA:
undetectable		 2tsrB-1q8rA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfj PROTEIN (FLAVIN
REDUCTASE)

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 ASP A 227
GLY A 226
PHE A 225
TYR A  35
 GOL  A 601 (-4.2A)
None
None
GOL  A 601 (-3.4A)
 0.95A 2tsrB-1qfjA:
undetectable		 2tsrB-1qfjA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)

(Streptomyces
venezuelae) 		PF07931
(CPT) 		5 ARG A  88
ILE A  89
ASP A  93
GLY A  35
PHE A  34
 None
 1.46A 2tsrB-1qhxA:
undetectable		 2tsrB-1qhxA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE

(Mus musculus) 		PF02348
(CTP_transf_3) 		4 ARG A 258
ASP A  79
GLY A 266
PHE A 265
 None
 0.88A 2tsrB-1qwjA:
undetectable		 2tsrB-1qwjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxp MU-LIKE CALPAIN

(Bos taurus;
Rattus
norvegicus) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 ILE A  73
TRP A  75
LEU A  63
GLY A  59
 None
 0.96A 2tsrB-1qxpA:
undetectable		 2tsrB-1qxpA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind) 		4 ARG A 396
ASP B 328
GLY B 329
PHE A 516
 None
 0.86A 2tsrB-1r4nA:
undetectable		 2tsrB-1r4nA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE

(Cryptococcus
neoformans) 		PF00475
(IGPD) 		5 ARG A 182
ILE A 181
LEU A  81
GLY A  82
PHE A  85
 None
 1.43A 2tsrB-1rhyA:
undetectable		 2tsrB-1rhyA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		4 ILE A  45
LEU A 210
GLY A 211
PHE A 214
 None
 0.68A 2tsrB-1rtrA:
undetectable		 2tsrB-1rtrA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		5 ARG A 284
ILE A 285
ASP A 234
GLY A 271
PHE A 298
 None
None
CA  A   1 (-3.4A)
None
None
 1.40A 2tsrB-1ru4A:
undetectable		 2tsrB-1ru4A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 ILE A 164
ASP A 151
LEU A 150
PHE A 153
 None
GLA  A 500 (-3.0A)
GLA  A 500 ( 4.4A)
None
 0.86A 2tsrB-1s4eA:
undetectable		 2tsrB-1s4eA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5j DNA POLYMERASE I

(Sulfolobus
solfataricus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ILE A 230
ASP A 261
LEU A 263
GLY A 259
 None
 0.93A 2tsrB-1s5jA:
undetectable		 2tsrB-1s5jA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ILE A 534
ASP A 714
GLY A 720
PHE A 719
 None
 0.94A 2tsrB-1sb3A:
undetectable		 2tsrB-1sb3A:
16.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tis THYMIDYLATE SYNTHASE

(Escherichia
virus T4) 		PF00303
(Thymidylat_synt) 		5 ASP A 179
LEU A 182
GLY A 183
PHE A 186
TYR A 219
 None
 0.97A 2tsrB-1tisA:
30.6		 2tsrB-1tisA:
41.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzx N UTILIZATION
SUBSTANCE PROTEIN B
HOMOLOG

(Thermotoga
maritima) 		PF01029
(NusB) 		4 ARG A  86
ASP A 128
GLY A 125
PHE A 122
 None
 0.92A 2tsrB-1tzxA:
undetectable		 2tsrB-1tzxA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ARG A  32
ASP A  44
LEU A  43
GLY A  42
 SO4  A 965 (-3.5A)
None
None
None
 0.95A 2tsrB-1uagA:
undetectable		 2tsrB-1uagA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3

(Homo sapiens) 		PF01088
(Peptidase_C12) 		4 ILE A 225
LEU A 100
GLY A  99
PHE A 170
 None
 0.87A 2tsrB-1uchA:
undetectable		 2tsrB-1uchA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 ILE A 327
LEU A 301
GLY A 268
PHE A 336
 None
 0.91A 2tsrB-1wb0A:
undetectable		 2tsrB-1wb0A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		4 ARG A  46
LEU A 175
GLY A 172
PHE A 171
 None
 0.92A 2tsrB-1wl1A:
undetectable		 2tsrB-1wl1A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ARG A 711
ILE A 714
LEU A 757
GLY A 756
 None
 0.92A 2tsrB-1z1wA:
undetectable		 2tsrB-1z1wA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		4 ILE A 129
GLY A 288
PHE A 307
TYR A 268
 None
 0.82A 2tsrB-1z7mA:
undetectable		 2tsrB-1z7mA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk5 F17G ADHESIN SUBUNIT

(Escherichia
coli) 		PF09222
(Fim-adh_lectin) 		4 ILE A 147
ASP A  61
GLY A 145
PHE A 166
 None
 0.91A 2tsrB-1zk5A:
undetectable		 2tsrB-1zk5A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ILE A 831
LEU A 856
GLY A 855
PHE A 854
 None
 0.95A 2tsrB-1zy4A:
undetectable		 2tsrB-1zy4A:
23.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		6 ILE A 100
ASP A 219
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 0.81A 2tsrB-2aazA:
undetectable		 2tsrB-2aazA:
59.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		6 ILE A 100
TRP A 101
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-3.7A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.72A 2tsrB-2aazA:
undetectable		 2tsrB-2aazA:
59.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amy PHOSPHOMANNOMUTASE 2

(Homo sapiens) 		PF03332
(PMM) 		4 ILE A 240
ASP A 209
GLY A 208
PHE A 207
 None
 0.85A 2tsrB-2amyA:
undetectable		 2tsrB-2amyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF10433
(MMS1_N) 		4 ARG A 567
LEU A 616
GLY A 615
PHE A 614
 None
 0.73A 2tsrB-2b5nA:
undetectable		 2tsrB-2b5nA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis) 		PF01182
(Glucosamine_iso) 		5 ARG A 192
ASP A  67
LEU A  66
GLY A 140
TYR A  80
 None
F6R  A1243 (-3.1A)
F6R  A1243 (-4.0A)
F6R  A1243 (-3.0A)
None
 1.46A 2tsrB-2bkxA:
undetectable		 2tsrB-2bkxA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmx ALKYL
HYDROPEROXIDASE C

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 ARG A  78
LEU A  83
GLY A  84
PHE A  51
 None
 0.88A 2tsrB-2bmxA:
undetectable		 2tsrB-2bmxA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct6 SH3 DOMAIN-BINDING
GLUTAMIC
ACID-RICH-LIKE
PROTEIN 2

(Homo sapiens) 		PF04908
(SH3BGR) 		4 ILE A  76
LEU A 104
GLY A 103
PHE A 101
 None
 0.95A 2tsrB-2ct6A:
undetectable		 2tsrB-2ct6A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6y PUTATIVE TETR FAMILY
REGULATORY PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 LEU A  55
GLY A  53
PHE A  56
TYR A  46
 None
 0.83A 2tsrB-2d6yA:
undetectable		 2tsrB-2d6yA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dej PROBABLE
GALACTOKINASE

(Pyrococcus
horikoshii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 ILE A 162
ASP A 149
LEU A 148
PHE A 151
 None
GLA  A 401 (-3.1A)
GLA  A 401 ( 4.3A)
None
 0.93A 2tsrB-2dejA:
undetectable		 2tsrB-2dejA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 ILE A 339
ASP A 272
LEU A 320
GLY A 319
 None
 0.87A 2tsrB-2exrA:
undetectable		 2tsrB-2exrA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnp TRANSCRIPTIONAL
REGULATOR

(Streptococcus
pneumoniae) 		PF04198
(Sugar-bind) 		4 ARG A 104
ILE A 107
GLY A 114
PHE A 138
 None
 0.87A 2tsrB-2gnpA:
undetectable		 2tsrB-2gnpA:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		6 ILE A 316
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 None
None
None
DU  A 611 (-3.5A)
None
DU  A 611 (-4.6A)
 0.66A 2tsrB-2h2qA:
40.3		 2tsrB-2h2qA:
38.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i53 CYCLIN K

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		4 ILE A 117
ASP A 134
GLY A 133
PHE A 132
 None
 0.91A 2tsrB-2i53A:
undetectable		 2tsrB-2i53A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idv EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-1

(Triticum
aestivum) 		PF01652
(IF4E) 		4 ILE A 166
ASP A 148
GLY A 147
PHE A 144
 None
 0.84A 2tsrB-2idvA:
undetectable		 2tsrB-2idvA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ARG A 269
ILE A 267
GLY A 114
PHE A 113
 None
 0.89A 2tsrB-2ifyA:
undetectable		 2tsrB-2ifyA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1q ARGININE KINASE

(Trypanosoma
cruzi) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 TRP A 221
ASP A 192
LEU A 195
GLY A 191
 None
 0.84A 2tsrB-2j1qA:
undetectable		 2tsrB-2j1qA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja2 GLUTAMYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00749
(tRNA-synt_1c) 		4 ARG A  25
ASP A 301
LEU A 300
PHE A 298
 CL  A1487 (-4.2A)
None
None
None
 0.88A 2tsrB-2ja2A:
undetectable		 2tsrB-2ja2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00698
(Acyl_transf_1)
PF16197
(KAsynt_C_assoc) 		5 ARG A 425
ILE A 800
ASP A 791
LEU A 793
PHE A 796
 None
 1.36A 2tsrB-2jfdA:
undetectable		 2tsrB-2jfdA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k1g LIPOPROTEIN SPR

(Escherichia
coli) 		PF00877
(NLPC_P60) 		4 ARG A 104
LEU A  82
GLY A  81
PHE A  80
 None
 0.91A 2tsrB-2k1gA:
undetectable		 2tsrB-2k1gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4j PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Helicobacter
pylori) 		PF00486
(Trans_reg_C) 		4 ILE A  23
LEU A 113
GLY A  58
TYR A 111
 None
 0.88A 2tsrB-2k4jA:
undetectable		 2tsrB-2k4jA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkd TRANSLATION
INITIATION FACTOR
IF-2

(Geobacillus
stearothermophilus) 		PF00009
(GTP_EFTU) 		4 ILE A  83
ASP A  61
LEU A  60
PHE A  59
 None
 0.90A 2tsrB-2lkdA:
undetectable		 2tsrB-2lkdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		4 ILE A 355
GLY A 247
PHE A 249
TYR A 214
 None
 0.77A 2tsrB-2o1oA:
undetectable		 2tsrB-2o1oA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi8 PUTATIVE REGULATORY
PROTEIN SCO4313

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 ARG A  45
ILE A  42
ASP A  61
GLY A  59
TYR A 118
 None
 1.44A 2tsrB-2oi8A:
undetectable		 2tsrB-2oi8A:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.58A 2tsrB-2oipA:
42.0		 2tsrB-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ILE A 315
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 0.99A 2tsrB-2oipA:
42.0		 2tsrB-2oipA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ILE A 315
TRP A 316
ASP A 426
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.66A 2tsrB-2oipA:
42.0		 2tsrB-2oipA:
35.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkd ZINC FINGER PROTEIN
ZPR1

(Mus musculus) 		PF03367
(zf-ZPR1) 		4 ARG A 126
ILE A 134
LEU A 157
GLY A 156
 None
 0.80A 2tsrB-2qkdA:
undetectable		 2tsrB-2qkdA:
22.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei) 		PF00303
(Thymidylat_synt) 		5 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.81A 2tsrB-2tddA:
34.1		 2tsrB-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei) 		PF00303
(Thymidylat_synt) 		5 ILE A  81
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 1.07A 2tsrB-2tddA:
34.1		 2tsrB-2tddA:
43.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 ARG G 264
ILE G 283
GLY G 276
PHE G 160
 None
 0.76A 2tsrB-2uv8G:
undetectable		 2tsrB-2uv8G:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9f CELL DIVISION
PROTEIN KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG B 163
ILE B 136
LEU B 128
GLY B 127
 None
 0.81A 2tsrB-2w9fB:
undetectable		 2tsrB-2w9fB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		5 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.17A 2tsrB-2wedA:
undetectable		 2tsrB-2wedA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Pisum sativum) 		PF01652
(IF4E) 		4 ILE A 179
ASP A 161
GLY A 160
PHE A 157
 None
 0.78A 2tsrB-2wmcA:
undetectable		 2tsrB-2wmcA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7m ARCHAEMETZINCIN

(Methanopyrus
kandleri) 		PF07998
(Peptidase_M54) 		4 ARG A  21
ILE A  18
LEU A  74
GLY A  75
 None
 0.80A 2tsrB-2x7mA:
undetectable		 2tsrB-2x7mA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE

(Lactobacillus
delbrueckii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A 159
LEU A 153
GLY A 155
TYR A 191
 None
 0.93A 2tsrB-2yq4A:
undetectable		 2tsrB-2yq4A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 ARG A 174
ILE A 173
ASP A 162
LEU A 161
PHE A 164
 None
 1.40A 2tsrB-2yxxA:
undetectable		 2tsrB-2yxxA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 ILE A  87
ASP B 313
GLY A 191
PHE A 193
 None
 0.92A 2tsrB-2z2mA:
undetectable		 2tsrB-2z2mA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhy ATP:COB(I)ALAMIN
ADENOSYLTRANSFERASE,
PUTATIVE

(Burkholderia
thailandensis) 		PF01923
(Cob_adeno_trans) 		4 ARG A 150
ILE A  84
LEU A  76
GLY A  73
 None
 0.87A 2tsrB-2zhyA:
undetectable		 2tsrB-2zhyA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		4 ILE A 603
ASP A  34
LEU A  31
GLY A  32
 None
 0.96A 2tsrB-2zuyA:
undetectable		 2tsrB-2zuyA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ILE A 520
LEU A 546
GLY A 576
TYR A 525
 None
 0.95A 2tsrB-3bgaA:
undetectable		 2tsrB-3bgaA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN-TYPE

(Toxoplasma
gondii) 		PF00160
(Pro_isomerase) 		4 ILE A 121
ASP A 144
LEU A 143
GLY A 142
 None
 0.76A 2tsrB-3bo7A:
undetectable		 2tsrB-3bo7A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs4 UNCHARACTERIZED
PROTEIN PH0321

(Pyrococcus
horikoshii) 		no annotation 4 ARG A  43
ILE A  40
PHE A 185
TYR A  58
 None
 0.63A 2tsrB-3bs4A:
undetectable		 2tsrB-3bs4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btz ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 2

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		4 ARG A 142
ILE A 141
GLY A 221
PHE A  73
 None
 0.88A 2tsrB-3btzA:
undetectable		 2tsrB-3btzA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		4 ARG A 296
ILE A 354
GLY A 303
PHE A 302
 None
 0.84A 2tsrB-3buzA:
undetectable		 2tsrB-3buzA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2t DEOXYURIDINE
TRIPHOSPHATASE

(Paramecium
bursaria
Chlorella virus
IL3A) 		PF00692
(dUTPase) 		4 ARG A  51
ILE A  50
LEU A   9
GLY A  47
 None
 0.65A 2tsrB-3c2tA:
undetectable		 2tsrB-3c2tA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ca9 DEOXYURIDINE
TRIPHOSPHATASE

(Paramecium
bursaria
Chlorella virus
IL3A) 		PF00692
(dUTPase) 		4 ARG A  51
ILE A  50
LEU A   9
GLY A  47
 None
 0.91A 2tsrB-3ca9A:
undetectable		 2tsrB-3ca9A:
21.45