SIMILAR PATTERNS OF AMINO ACIDS FOR 2TSR_A_D16A309_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

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	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1am5	PEPSIN (Gadus morhua)	PF00026 (Asp)	5	ASP A 303 LEU A 306 GLY A 302 PHE A 301 TYR A 14	None	1.18A	2tsrA-1am5A: 0.0	2tsrA-1am5A: 22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1bsf	THYMIDYLATE SYNTHASE A (Bacillus subtilis)	PF00303 (Thymidylat_synt)	4	ASP A 184 GLY A 188 PHE A 191 TYR A 224	None	0.29A	2tsrA-1bsfA: 31.6	2tsrA-1bsfA: 35.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1bsf	THYMIDYLATE SYNTHASE A (Bacillus subtilis)	PF00303 (Thymidylat_synt)	4	ILE A 93 ASP A 184 GLY A 188 TYR A 224	None	0.60A	2tsrA-1bsfA: 31.6	2tsrA-1bsfA: 35.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ci7	PROTEIN (THYMIDYLATE SYNTHASE) (Pneumocystis carinii)	PF00303 (Thymidylat_synt)	6	ILE A 86 ASP A 202 LEU A 205 GLY A 206 PHE A 209 TYR A 242	CB3 A 768 (-3.6A) CB3 A 768 ( 3.6A) CB3 A 768 ( 4.4A) UMP A 767 (-3.7A) CB3 A 768 (-3.6A) CB3 A 768 ( 4.7A)	0.58A	2tsrA-1ci7A: 41.0	2tsrA-1ci7A: 58.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1cov	COXSACKIEVIRUS COAT PROTEIN (Enterovirus B)	PF00073 (Rhv)	4	ILE 3 114 LEU 3 104 GLY 3 101 PHE 3 95	None	0.70A	2tsrA-1cov3: 0.0	2tsrA-1cov3: 20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1gxl	CHROMOSOME SEGREGATION SMC PROTEIN (Thermotoga maritima)	PF06470 (SMC_hinge)	4	ILE A 524 LEU A 609 GLY A 610 PHE A 614	None	0.83A	2tsrA-1gxlA: 0.0	2tsrA-1gxlA: 22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1hv5	STROMELYSIN 3 (Mus musculus)	PF00413 (Peptidase_M10)	4	ILE A 159 LEU A 225 GLY A 222 PHE A 221	None	0.78A	2tsrA-1hv5A: undetectable	2tsrA-1hv5A: 20.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvy	THYMIDYLATE SYNTHASE (Homo sapiens)	PF00303 (Thymidylat_synt)	6	ILE A 108 ASP A 218 LEU A 221 GLY A 222 PHE A 225 TYR A 258	D16 A 414 (-3.7A) D16 A 414 ( 3.6A) D16 A 414 (-4.0A) D16 A 414 (-3.3A) D16 A 414 (-3.6A) UMP A 314 ( 4.4A)	0.57A	2tsrA-1hvyA: 44.0	2tsrA-1hvyA: 92.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ize	ASPARTIC PROTEINASE (Aspergillus oryzae)	PF00026 (Asp)	5	ASP A 300 LEU A 303 GLY A 299 PHE A 298 TYR A 17	None	1.16A	2tsrA-1izeA: 0.0	2tsrA-1izeA: 21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1j3j	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE (Plasmodium falciparum)	PF00303 (Thymidylat_synt)	4	ASP C 513 LEU C 516 GLY C 517 TYR C 553	UMP C 611 (-4.9A) None UMP C 611 (-3.5A) UMP C 611 (-4.9A)	0.59A	2tsrA-1j3jC: 40.4	2tsrA-1j3jC: 50.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1j3j	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE (Plasmodium falciparum)	PF00303 (Thymidylat_synt)	4	ILE C 403 ASP C 513 GLY C 517 TYR C 553	None UMP C 611 (-4.9A) UMP C 611 (-3.5A) UMP C 611 (-4.9A)	0.42A	2tsrA-1j3jC: 40.4	2tsrA-1j3jC: 50.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1l6j	MATRIX METALLOPROTEINASE-9 (Homo sapiens)	PF00040 (fn2) PF00413 (Peptidase_M10) PF01471 (PG_binding_1)	4	ILE A 166 LEU A 407 GLY A 404 PHE A 403	None	0.87A	2tsrA-1l6jA: undetectable	2tsrA-1l6jA: 21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1pmj	BETA-1,4-MANNANASE (Caldicellulosiruptor saccharolyticus)	PF09212 (CBM27)	4	ILE X 173 ASP X 61 GLY X 164 PHE X 103	None	0.88A	2tsrA-1pmjX: undetectable	2tsrA-1pmjX: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1rtr	GERANYLTRANSTRANSFER ASE (Staphylococcus aureus)	PF00348 (polyprenyl_synt)	4	ILE A 45 LEU A 210 GLY A 211 PHE A 214	None	0.52A	2tsrA-1rtrA: undetectable	2tsrA-1rtrA: 23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1sch	PEANUT PEROXIDASE, MAJOR CATIONIC ISOZYME (Arachis hypogaea)	PF00141 (peroxidase)	4	ILE A 183 ASP A 239 LEU A 235 GLY A 234	None	0.89A	2tsrA-1schA: undetectable	2tsrA-1schA: 20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1tis	THYMIDYLATE SYNTHASE (Escherichia virus T4)	PF00303 (Thymidylat_synt)	4	ASP A 179 GLY A 183 PHE A 186 TYR A 219	None	0.46A	2tsrA-1tisA: 30.8	2tsrA-1tisA: 41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1tis	THYMIDYLATE SYNTHASE (Escherichia virus T4)	PF00303 (Thymidylat_synt)	4	ASP A 179 LEU A 182 GLY A 183 TYR A 219	None	0.46A	2tsrA-1tisA: 30.8	2tsrA-1tisA: 41.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1uch	UBIQUITIN C-TERMINAL HYDROLASE UCH-L3 (Homo sapiens)	PF01088 (Peptidase_C12)	4	ILE A 225 LEU A 100 GLY A 99 PHE A 170	None	0.88A	2tsrA-1uchA: undetectable	2tsrA-1uchA: 22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2aaz	THYMIDYLATE SYNTHASE (Cryptococcus neoformans)	PF00303 (Thymidylat_synt)	5	ILE A 100 ASP A 219 LEU A 222 GLY A 223 TYR A 259	CB3 A2351 (-3.6A) CB3 A2351 ( 3.6A) CB3 A2351 (-4.1A) CB3 A2351 ( 3.2A) CB3 A2351 ( 4.3A)	0.69A	2tsrA-2aazA: undetectable	2tsrA-2aazA: 59.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2aaz	THYMIDYLATE SYNTHASE (Cryptococcus neoformans)	PF00303 (Thymidylat_synt)	5	ILE A 100 LEU A 222 GLY A 223 PHE A 226 TYR A 259	CB3 A2351 (-3.6A) CB3 A2351 (-4.1A) CB3 A2351 ( 3.2A) CB3 A2351 (-3.8A) CB3 A2351 ( 4.3A)	1.02A	2tsrA-2aazA: undetectable	2tsrA-2aazA: 59.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2amy	PHOSPHOMANNOMUTASE 2 (Homo sapiens)	PF03332 (PMM)	4	ILE A 240 ASP A 209 GLY A 208 PHE A 207	None	0.81A	2tsrA-2amyA: undetectable	2tsrA-2amyA: 22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2cb1	O-ACETYL HOMOSERINE SULFHYDRYLASE (Thermus thermophilus)	PF01053 (Cys_Met_Meta_PP)	4	LEU A 185 GLY A 180 PHE A 179 TYR A 3	None	0.86A	2tsrA-2cb1A: undetectable	2tsrA-2cb1A: 23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2drq	XYLANASE Y (Bacillus halodurans)	PF01270 (Glyco_hydro_8)	4	ILE A 87 ASP A 42 GLY A 41 PHE A 40	None	0.89A	2tsrA-2drqA: undetectable	2tsrA-2drqA: 20.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2h2q	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE (Trypanosoma cruzi)	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	5	ASP A 426 LEU A 429 GLY A 430 PHE A 433 TYR A 466	None None DU A 611 (-3.5A) None DU A 611 (-4.6A)	0.65A	2tsrA-2h2qA: 40.5	2tsrA-2h2qA: 38.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2h2q	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE (Trypanosoma cruzi)	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	5	ILE A 316 ASP A 426 GLY A 430 PHE A 433 TYR A 466	None None DU A 611 (-3.5A) None DU A 611 (-4.6A)	0.41A	2tsrA-2h2qA: 40.5	2tsrA-2h2qA: 38.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2i53	CYCLIN K (Homo sapiens)	PF00134 (Cyclin_N) PF02984 (Cyclin_C)	4	ILE A 117 ASP A 134 GLY A 133 PHE A 132	None	0.86A	2tsrA-2i53A: undetectable	2tsrA-2i53A: 21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2idv	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-1 (Triticum aestivum)	PF01652 (IF4E)	4	ILE A 166 ASP A 148 GLY A 147 PHE A 144	None	0.77A	2tsrA-2idvA: undetectable	2tsrA-2idvA: 18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ivg	CYANATE LYASE (Escherichia coli)	PF02560 (Cyanate_lyase)	4	ILE A 121 ASP A 118 GLY A 117 PHE A 116	None	0.90A	2tsrA-2ivgA: undetectable	2tsrA-2ivgA: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2o1o	PUTATIVE FARNESYL PYROPHOSPHATE SYNTHASE (Cryptosporidium parvum)	PF00348 (polyprenyl_synt)	4	ILE A 355 GLY A 247 PHE A 249 TYR A 214	None	0.78A	2tsrA-2o1oA: undetectable	2tsrA-2o1oA: 21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2oip	CHAIN A, CRYSTAL STRUCTURE OF DHFR (Cryptosporidium hominis)	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	5	ILE A 315 ASP A 426 LEU A 429 GLY A 430 TYR A 466	CB3 A 604 ( 3.7A) CB3 A 604 ( 3.9A) CB3 A 604 ( 4.4A) CB3 A 604 ( 3.4A) UMP A 603 ( 4.3A)	0.70A	2tsrA-2oipA: 41.4	2tsrA-2oipA: 35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2tdd	THYMIDYLATE SYNTHASE (Lactobacillus casei)	PF00303 (Thymidylat_synt)	4	ASP A 221 LEU A 224 GLY A 225 TYR A 261	UFP A 529 (-4.7A) THF A 568 (-3.6A) UFP A 529 ( 4.0A) UFP A 529 (-4.7A)	0.85A	2tsrA-2tddA: 33.8	2tsrA-2tddA: 43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2tdd	THYMIDYLATE SYNTHASE (Lactobacillus casei)	PF00303 (Thymidylat_synt)	4	ILE A 81 ASP A 221 GLY A 225 TYR A 261	THF A 568 ( 4.8A) UFP A 529 (-4.7A) UFP A 529 ( 4.0A) UFP A 529 (-4.7A)	0.64A	2tsrA-2tddA: 33.8	2tsrA-2tddA: 43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2tdd	THYMIDYLATE SYNTHASE (Lactobacillus casei)	PF00303 (Thymidylat_synt)	4	LEU A 224 GLY A 225 PHE A 228 TYR A 261	THF A 568 (-3.6A) UFP A 529 ( 4.0A) THF A 568 (-4.8A) UFP A 529 (-4.7A)	0.82A	2tsrA-2tddA: 33.8	2tsrA-2tddA: 43.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2vn8	RETICULON-4-INTERACT ING PROTEIN 1 (Homo sapiens)	PF08240 (ADH_N) PF13602 (ADH_zinc_N_2)	4	ARG A 103 ILE A 86 LEU A 119 GLY A 120	None	0.79A	2tsrA-2vn8A: undetectable	2tsrA-2vn8A: 22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2wed	PENICILLOPEPSIN (Penicillium janthinellum)	PF00026 (Asp)	5	ASP A 300 LEU A 303 GLY A 299 PHE A 298 TYR A 17	None	1.20A	2tsrA-2wedA: undetectable	2tsrA-2wedA: 20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2wmc	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E (Pisum sativum)	PF01652 (IF4E)	4	ILE A 179 ASP A 161 GLY A 160 PHE A 157	None	0.69A	2tsrA-2wmcA: undetectable	2tsrA-2wmcA: 17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3bo7	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE CYCLOPHILIN-TYPE (Toxoplasma gondii)	PF00160 (Pro_isomerase)	4	ILE A 121 ASP A 144 LEU A 143 GLY A 142	None	0.71A	2tsrA-3bo7A: undetectable	2tsrA-3bo7A: 19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3bw2	2-NITROPROPANE DIOXYGENASE (Streptomyces ansochromogenes)	PF03060 (NMO)	4	ARG A 329 ILE A 13 GLY A 237 PHE A 240	None None FMN A 370 (-3.2A) None	0.88A	2tsrA-3bw2A: undetectable	2tsrA-3bw2A: 21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3emy	TRICHODERMA REESEI ASPARTIC PROTEASE (Trichoderma reesei)	PF00026 (Asp)	5	ASP A 304 LEU A 307 GLY A 303 PHE A 302 TYR A 14	None	1.14A	2tsrA-3emyA: undetectable	2tsrA-3emyA: 19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3heb	RESPONSE REGULATOR RECEIVER DOMAIN PROTEIN (CHEY) (Rhodospirillum rubrum)	PF00072 (Response_reg)	4	ILE A 10 LEU A 135 GLY A 136 PHE A 139	None	0.65A	2tsrA-3hebA: undetectable	2tsrA-3hebA: 21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ix6	THYMIDYLATE SYNTHASE (Brucella melitensis)	PF00303 (Thymidylat_synt)	4	ASP A 169 LEU A 172 GLY A 173 TYR A 209	None	0.77A	2tsrA-3ix6A: 33.6	2tsrA-3ix6A: 41.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3kgb	THYMIDYLATE SYNTHASE 1/2 (Encephalitozoon cuniculi)	PF00303 (Thymidylat_synt)	4	LEU A 200 GLY A 201 PHE A 204 TYR A 237	None	0.64A	2tsrA-3kgbA: 36.5	2tsrA-3kgbA: 57.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3kjr	DIHYDROFOLATE REDUCTASE/THYMIDYLAT E SYNTHASE (Babesia bovis)	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	4	ASP A 416 LEU A 419 GLY A 420 TYR A 456	None	0.61A	2tsrA-3kjrA: 40.9	2tsrA-3kjrA: 34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3kq5	HYPOTHETICAL CYTOSOLIC PROTEIN (Coxiella burnetii)	PF07515 (TraI_2_C)	4	ILE A 367 LEU A 320 GLY A 319 PHE A 318	None	0.76A	2tsrA-3kq5A: undetectable	2tsrA-3kq5A: 23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3o7t	CYCLOPHILIN A (Moniliophthora perniciosa)	PF00160 (Pro_isomerase)	4	ILE A 112 ASP A 135 LEU A 134 GLY A 133	None	0.73A	2tsrA-3o7tA: undetectable	2tsrA-3o7tA: 18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA 6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	PF00365 (PFK)	4	ARG B 383 ILE A 355 ASP A 309 GLY A 308	F6P A 988 (-2.3A) F6P A 988 (-4.9A) None None	0.77A	2tsrA-3o8oB: undetectable	2tsrA-3o8oB: 18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3thn	EXONUCLEASE, PUTATIVE (Thermotoga maritima)	PF00149 (Metallophos)	4	ILE A 230 ASP A 14 GLY A 233 PHE A 220	None MN A 360 (-3.4A) None None	0.79A	2tsrA-3thnA: undetectable	2tsrA-3thnA: 20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3tho	EXONUCLEASE, PUTATIVE (Thermotoga maritima)	PF00149 (Metallophos)	4	ILE B 230 ASP B 14 GLY B 233 PHE B 220	None MN B 1 (-3.7A) None None	0.77A	2tsrA-3thoB: undetectable	2tsrA-3thoB: 20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3uca	GERANYLTRANSTRANSFER ASE (Clostridium perfringens)	PF00348 (polyprenyl_synt)	4	ILE A 54 LEU A 220 GLY A 221 PHE A 224	None	0.76A	2tsrA-3ucaA: undetectable	2tsrA-3ucaA: 23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3um6	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE (Plasmodium falciparum)	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	4	ASP A 513 LEU A 516 GLY A 517 TYR A 553	UMP A 611 (-4.9A) None UMP A 611 (-3.3A) UMP A 611 (-4.5A)	0.60A	2tsrA-3um6A: 40.7	2tsrA-3um6A: 28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3um6	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE (Plasmodium falciparum)	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	4	ILE A 403 ASP A 513 GLY A 517 TYR A 553	None UMP A 611 (-4.9A) UMP A 611 (-3.3A) UMP A 611 (-4.5A)	0.44A	2tsrA-3um6A: 40.7	2tsrA-3um6A: 28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3usz	EXO-1,3/1,4-BETA-GLU CANASE (Pseudoalteromonas sp. BB1)	PF00933 (Glyco_hydro_3) PF01915 (Glyco_hydro_3_C)	4	ILE A 210 ASP A 287 GLY A 288 PHE A 289	None	0.82A	2tsrA-3uszA: undetectable	2tsrA-3uszA: 15.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3v8h	THYMIDYLATE SYNTHASE (Burkholderia thailandensis)	PF00303 (Thymidylat_synt)	4	ASP A 217 GLY A 221 PHE A 224 TYR A 257	None None None CIT A 400 (-4.5A)	0.52A	2tsrA-3v8hA: 34.5	2tsrA-3v8hA: 34.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3v8h	THYMIDYLATE SYNTHASE (Burkholderia thailandensis)	PF00303 (Thymidylat_synt)	4	LEU A 220 GLY A 221 PHE A 224 TYR A 257	None None None CIT A 400 (-4.5A)	0.79A	2tsrA-3v8hA: 34.5	2tsrA-3v8hA: 34.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3wjo	OCTAPRENYL DIPHOSPHATE SYNTHASE (Escherichia coli)	PF00348 (polyprenyl_synt)	4	ILE A 47 LEU A 203 GLY A 204 PHE A 207	None None None IPE A 402 (-4.5A)	0.60A	2tsrA-3wjoA: undetectable	2tsrA-3wjoA: 22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4aee	ALPHA AMYLASE, CATALYTIC REGION (Staphylothermus marinus)	PF00128 (Alpha-amylase)	4	ILE A 447 LEU A 472 GLY A 470 TYR A 489	None	0.83A	2tsrA-4aeeA: undetectable	2tsrA-4aeeA: 17.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4dq1	THYMIDYLATE SYNTHASE (Staphylococcus aureus)	PF00303 (Thymidylat_synt)	4	ASP A 224 LEU A 227 GLY A 228 TYR A 264	None None UMP A 501 ( 4.0A) UMP A 501 (-4.2A)	0.74A	2tsrA-4dq1A: 34.2	2tsrA-4dq1A: 46.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4dq1	THYMIDYLATE SYNTHASE (Staphylococcus aureus)	PF00303 (Thymidylat_synt)	5	ILE A 84 ASP A 224 GLY A 228 PHE A 231 TYR A 264	None None UMP A 501 ( 4.0A) None UMP A 501 (-4.2A)	0.53A	2tsrA-4dq1A: 34.2	2tsrA-4dq1A: 46.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4fog	THYMIDYLATE SYNTHASE (Mycobacterium tuberculosis)	PF00303 (Thymidylat_synt)	4	ILE A 79 ASP A 169 GLY A 173 TYR A 209	C2F A 302 (-3.3A) C2F A 302 ( 3.9A) C2F A 302 (-3.2A) C2F A 302 ( 4.6A)	0.46A	2tsrA-4fogA: 36.8	2tsrA-4fogA: 47.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4fvl	COLLAGENASE 3 (Homo sapiens)	PF00045 (Hemopexin) PF00413 (Peptidase_M10)	4	ILE A 163 LEU A 228 GLY A 225 PHE A 224	None	0.90A	2tsrA-4fvlA: undetectable	2tsrA-4fvlA: 22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4h0u	THYMIDYLATE SYNTHASE (Corynebacterium glutamicum)	PF00303 (Thymidylat_synt)	4	ASP A 172 LEU A 175 GLY A 176 TYR A 212	None None UMP A 301 (-3.6A) UMP A 301 (-4.5A)	0.72A	2tsrA-4h0uA: 35.7	2tsrA-4h0uA: 46.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4h0u	THYMIDYLATE SYNTHASE (Corynebacterium glutamicum)	PF00303 (Thymidylat_synt)	4	ILE A 82 ASP A 172 GLY A 176 TYR A 212	None None UMP A 301 (-3.6A) UMP A 301 (-4.5A)	0.47A	2tsrA-4h0uA: 35.7	2tsrA-4h0uA: 46.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4h1x	PHOSPHATE-BINDING PROTEIN PSTS 2 (Streptococcus pneumoniae)	PF12849 (PBP_like_2)	4	ILE A 212 LEU A 143 GLY A 144 PHE A 147	None	0.41A	2tsrA-4h1xA: undetectable	2tsrA-4h1xA: 20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4iqq	THYMIDYLATE SYNTHASE (Caenorhabditis elegans)	PF00303 (Thymidylat_synt)	6	ILE A 110 ASP A 220 LEU A 223 GLY A 224 PHE A 227 TYR A 260	D16 A 402 (-4.0A) D16 A 402 ( 4.0A) D16 A 402 (-3.7A) D16 A 402 ( 3.1A) D16 A 402 (-3.2A) D16 A 402 ( 4.2A)	0.22A	2tsrA-4iqqA: 43.0	2tsrA-4iqqA: 63.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4k6l	CYTOLETHAL DISTENDING TOXIN SUBUNIT B HOMOLOG (Salmonella enterica)	PF03372 (Exo_endo_phos)	4	ILE F 124 ASP F 131 LEU F 151 GLY F 150	None	0.75A	2tsrA-4k6lF: undetectable	2tsrA-4k6lF: 20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4kzs	LPP20 LIPOFAMILY PROTEIN (Helicobacter pylori)	PF02169 (LPP20)	4	ILE A 171 ASP A 130 GLY A 127 PHE A 124	None	0.86A	2tsrA-4kzsA: undetectable	2tsrA-4kzsA: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4myo	VIRGINIAMYCIN A ACETYLTRANSFERASE (Staphylococcus aureus)	PF00132 (Hexapep)	4	ARG A 170 ILE A 178 ASP A 124 GLY A 142	None	0.78A	2tsrA-4myoA: undetectable	2tsrA-4myoA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4o3s	DNA POLYMERASE ETA (Homo sapiens)	PF00817 (IMS) PF11799 (IMS_C)	4	ILE A 255 LEU A 278 GLY A 276 PHE A 247	None None GOL A 504 (-3.2A) None	0.90A	2tsrA-4o3sA: undetectable	2tsrA-4o3sA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4p6v	NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT A (Vibrio cholerae)	PF05896 (NQRA) PF11973 (NQRA_SLBB)	4	ILE A 239 ASP A 179 LEU A 178 GLY A 177	None	0.90A	2tsrA-4p6vA: undetectable	2tsrA-4p6vA: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4pph	CONGLUTIN GAMMA (Lupinus angustifolius)	PF14541 (TAXi_C) PF14543 (TAXi_N)	4	ARG A 193 ILE A 344 GLY A 361 TYR A 319	None	0.87A	2tsrA-4pphA: undetectable	2tsrA-4pphA: 19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4prk	4-PHOSPHOERYTHRONATE DEHYDROGENASE (Lactobacillus jensenii)	PF00389 (2-Hacid_dh) PF02826 (2-Hacid_dh_C)	4	ILE A 157 LEU A 151 GLY A 153 TYR A 189	None	0.89A	2tsrA-4prkA: undetectable	2tsrA-4prkA: 21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4rjz	ABC TRANSPORTER, SUBSTRATE BINDING PROTEIN (SUGAR) (Agrobacterium fabrum)	PF01547 (SBP_bac_1)	4	ILE A 88 GLY A 136 PHE A 102 TYR A 120	None	0.74A	2tsrA-4rjzA: undetectable	2tsrA-4rjzA: 21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xct	MATRIX METALLOPROTEINASE-9, MATRIX METALLOPROTEINASE-9 (Homo sapiens)	PF00413 (Peptidase_M10)	4	ILE A 166 LEU A 232 GLY A 229 PHE A 228	None	0.88A	2tsrA-4xctA: undetectable	2tsrA-4xctA: 17.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4xsc	THYMIDYLATE SYNTHASE (Human alphaherpesvirus 3)	PF00303 (Thymidylat_synt)	5	ILE A 96 ASP A 206 GLY A 210 PHE A 213 TYR A 246	1PE A1002 (-4.6A) None BVP A1001 (-3.4A) 1PE A1002 (-3.8A) BVP A1001 (-4.5A)	0.28A	2tsrA-4xscA: 40.8	2tsrA-4xscA: 65.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5by6	THYMIDYLATE SYNTHASE (Trichinella spiralis)	PF00303 (Thymidylat_synt)	4	ASP A 212 LEU A 215 GLY A 216 TYR A 252	None None UMP A 401 (-3.5A) UMP A 401 (-4.6A)	0.71A	2tsrA-5by6A: 43.0	2tsrA-5by6A: 62.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5by6	THYMIDYLATE SYNTHASE (Trichinella spiralis)	PF00303 (Thymidylat_synt)	5	ILE A 102 ASP A 212 GLY A 216 PHE A 219 TYR A 252	DTT A 402 ( 4.3A) None UMP A 401 (-3.5A) DTT A 402 ( 4.1A) UMP A 401 (-4.6A)	0.41A	2tsrA-5by6A: 43.0	2tsrA-5by6A: 62.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5e3q	2,3,4,5-TETRAHYDROPY RIDINE-2,6-DICARBOXY LATE N-SUCCINYLTRANSFERAS E (Corynebacterium glutamicum)	PF14602 (Hexapep_2) PF14789 (THDPS_M)	4	ILE A 89 LEU A 74 GLY A 153 PHE A 170	None	0.77A	2tsrA-5e3qA: undetectable	2tsrA-5e3qA: 21.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5h3a	ORF70 (Human gammaherpesvirus 8)	PF00303 (Thymidylat_synt)	5	ILE A 132 ASP A 242 GLY A 246 PHE A 249 TYR A 282	D16 A 401 ( 4.0A) D16 A 401 ( 4.0A) D16 A 401 ( 3.2A) D16 A 401 (-3.4A) UMP A 402 (-4.5A)	0.23A	2tsrA-5h3aA: 43.9	2tsrA-5h3aA: 70.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5hct	ENDOTHIAPEPSIN (Cryphonectria parasitica)	PF00026 (Asp)	5	ASP A 307 LEU A 310 GLY A 306 PHE A 305 TYR A 17	None	1.12A	2tsrA-5hctA: undetectable	2tsrA-5hctA: 19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5iai	SUGAR ABC TRANSPORTER (Agrobacterium tumefaciens)	PF01547 (SBP_bac_1)	4	ILE A 131 LEU A 139 GLY A 140 PHE A 149	None	0.85A	2tsrA-5iaiA: undetectable	2tsrA-5iaiA: 20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5iw7	RIBOSOME BIOGENESIS PROTEIN TSR1,RIBOSOME BIOGENESIS PROTEIN TSR1 (Saccharomyces cerevisiae)	PF04950 (RIBIOP_C) PF08142 (AARP2CN)	4	ILE A 177 LEU A 162 GLY A 161 PHE A 160	None	0.75A	2tsrA-5iw7A: undetectable	2tsrA-5iw7A: 18.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5j7w	THYMIDYLATE SYNTHASE (Enterococcus faecalis)	PF00303 (Thymidylat_synt)	5	ASP A 220 LEU A 223 GLY A 224 PHE A 227 TYR A 260	None	0.76A	2tsrA-5j7wA: 33.9	2tsrA-5j7wA: 47.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5j7w	THYMIDYLATE SYNTHASE (Enterococcus faecalis)	PF00303 (Thymidylat_synt)	4	ILE A 80 ASP A 220 PHE A 227 TYR A 260	None	0.65A	2tsrA-5j7wA: 33.9	2tsrA-5j7wA: 47.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5k0u	CAPSID PROTEIN VP3 (Rhinovirus C)	PF00073 (Rhv)	4	ILE B 112 LEU B 102 GLY B 99 PHE B 93	None	0.86A	2tsrA-5k0uB: undetectable	2tsrA-5k0uB: 22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5mac	RIBULOSE-1,5-BISPHOS PHATE CARBOXYLASE-OXYGENAS E TYPE III (Methanococcoides burtonii)	PF00016 (RuBisCO_large) PF02788 (RuBisCO_large_N)	4	ARG A 151 ILE A 397 GLY A 163 PHE A 191	None None None KCX A 193 ( 4.8A)	0.89A	2tsrA-5macA: undetectable	2tsrA-5macA: 21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5min	QUINOPROTEIN GLUCOSE DEHYDROGENASE B (Acinetobacter calcoaceticus)	no annotation	4	ILE A 94 LEU A 149 GLY A 81 PHE A 82	None	0.73A	2tsrA-5minA: undetectable	2tsrA-5minA: 15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5p60	ENDOTHIAPEPSIN (Cryphonectria parasitica)	PF00026 (Asp)	5	ASP A 307 LEU A 310 GLY A 306 PHE A 305 TYR A 17	None	1.11A	2tsrA-5p60A: undetectable	2tsrA-5p60A: 18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5sy5	NEURONAL PAS DOMAIN-CONTAINING PROTEIN 1 (Mus musculus)	PF00010 (HLH) PF00989 (PAS) PF08447 (PAS_3)	4	ILE B 271 ASP B 147 GLY B 148 PHE B 149	None	0.83A	2tsrA-5sy5B: undetectable	2tsrA-5sy5B: 20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5sy7	NEURONAL PAS DOMAIN-CONTAINING PROTEIN 3 (Mus musculus)	PF00010 (HLH) PF00989 (PAS) PF08447 (PAS_3)	4	ILE B 291 ASP B 164 GLY B 165 PHE B 166	None	0.72A	2tsrA-5sy7B: undetectable	2tsrA-5sy7B: 21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5t0l	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE (Toxoplasma gondii)	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	6	ARG A 603 ILE A 402 ASP A 513 LEU A 516 GLY A 517 PHE A 520	CB3 A 703 (-3.2A) CB3 A 703 (-3.4A) CB3 A 703 ( 3.8A) CB3 A 703 (-3.7A) CB3 A 703 ( 3.0A) CB3 A 703 (-3.8A)	0.94A	2tsrA-5t0lA: 42.3	2tsrA-5t0lA: 34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5t0l	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE (Toxoplasma gondii)	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	6	ILE A 402 ASP A 513 LEU A 516 GLY A 517 PHE A 520 TYR A 553	CB3 A 703 (-3.4A) CB3 A 703 ( 3.8A) CB3 A 703 (-3.7A) CB3 A 703 ( 3.0A) CB3 A 703 (-3.8A) UMP A 701 (-4.4A)	0.44A	2tsrA-5t0lA: 42.3	2tsrA-5t0lA: 34.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5th6	MATRIX METALLOPROTEINASE-9, MATRIX METALLOPROTEINASE-9 (Homo sapiens)	PF00413 (Peptidase_M10) PF01471 (PG_binding_1)	4	ILE A 166 LEU A 407 GLY A 404 PHE A 403	None	0.88A	2tsrA-5th6A: undetectable	2tsrA-5th6A: 21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5tw1	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Mycolicibacterium smegmatis)	PF00562 (RNA_pol_Rpb2_6) PF04560 (RNA_pol_Rpb2_7) PF04561 (RNA_pol_Rpb2_2) PF04563 (RNA_pol_Rpb2_1) PF04565 (RNA_pol_Rpb2_3) PF10385 (RNA_pol_Rpb2_45)	4	ILE C 627 LEU C 44 GLY C 43 TYR C 494	None	0.84A	2tsrA-5tw1C: undetectable	2tsrA-5tw1C: 12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5twt	PEROXIDASE PVI9 (Panicum virgatum)	PF00141 (peroxidase)	4	ILE A 181 ASP A 236 LEU A 232 GLY A 231	None	0.85A	2tsrA-5twtA: undetectable	2tsrA-5twtA: 21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5vt9	MYOSIN LIGHT CHAIN TGMLC1 (Toxoplasma gondii)	no annotation	4	ILE A 199 LEU A 174 GLY A 171 TYR A 177	None	0.86A	2tsrA-5vt9A: undetectable	2tsrA-5vt9A: 22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5y09	PROTEASE DO-LIKE 9 (Arabidopsis thaliana)	no annotation	4	ILE A 314 ASP A 222 GLY A 221 PHE A 220	None	0.90A	2tsrA-5y09A: undetectable	2tsrA-5y09A: 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5z9s	GLYCOSYL HYDROLASE FAMILY 3 PROTEIN (Bifidobacterium longum)	no annotation	4	ILE A 279 ASP A 95 LEU A 67 GLY A 94	None	0.85A	2tsrA-5z9sA: undetectable	2tsrA-5z9sA: 13.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6auj	THYMIDYLATE SYNTHASE (Elizabethkingia anophelis)	PF00303 (Thymidylat_synt)	5	ILE A 87 ASP A 177 GLY A 181 PHE A 184 TYR A 217	PGE A 301 ( 4.2A) None PGE A 301 ( 4.0A) PGE A 301 (-3.7A) None	0.54A	2tsrA-6aujA: 34.3	2tsrA-6aujA: 49.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6cdz	THYMIDYLATE SYNTHASE (Escherichia coli)	no annotation	5	ILE A 79 ASP A 169 GLY A 173 PHE A 176 TYR A 209	CB3 A 701 (-3.9A) CB3 A 701 ( 3.6A) CB3 A 701 (-3.3A) CB3 A 701 (-3.8A) UMP A 702 ( 4.2A)	0.33A	2tsrA-6cdzA: 37.0	2tsrA-6cdzA: 39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6cdz	THYMIDYLATE SYNTHASE (Escherichia coli)	no annotation	5	ILE A 79 LEU A 172 GLY A 173 PHE A 176 TYR A 209	CB3 A 701 (-3.9A) CB3 A 701 (-3.5A) CB3 A 701 (-3.3A) CB3 A 701 (-3.8A) UMP A 702 ( 4.2A)	0.48A	2tsrA-6cdzA: 37.0	2tsrA-6cdzA: 39.81

[["2TSR_A_D16A309_1","1am5","Gadus morhua","PEPSIN","PF00026(Asp)",5,"ASP A 303;LEU A 306;GLY A 302;PHE A 301;TYR A  14","None","1.18A","2tsrA-1am5A:0.0","2tsrA-1am5A:22.19"],["2TSR_A_D16A309_1","1bsf","Bacillus subtilis","THYMIDYLATE SYNTHASE A","PF00303(Thymidylat_synt)",4,"ASP A 184;GLY A 188;PHE A 191;TYR A 224","None","0.29A","2tsrA-1bsfA:31.6","2tsrA-1bsfA:35.16"],["2TSR_A_D16A309_1","1bsf","Bacillus subtilis","THYMIDYLATE SYNTHASE A","PF00303(Thymidylat_synt)",4,"ILE A  93;ASP A 184;GLY A 188;TYR A 224","None","0.60A","2tsrA-1bsfA:31.6","2tsrA-1bsfA:35.16"],["2TSR_A_D16A309_1","1ci7","Pneumocystis carinii","PROTEIN (THYMIDYLATE SYNTHASE)","PF00303(Thymidylat_synt)",6,"ILE A  86;ASP A 202;LEU A 205;GLY A 206;PHE A 209;TYR A 242","CB3 A 768 (-3.6A);CB3 A 768 ( 3.6A);CB3 A 768 ( 4.4A);UMP A 767 (-3.7A);CB3 A 768 (-3.6A);CB3 A 768 ( 4.7A)","0.58A","2tsrA-1ci7A:41.0","2tsrA-1ci7A:58.41"],["2TSR_A_D16A309_1","1cov","Enterovirus B","COXSACKIEVIRUS COAT PROTEIN","PF00073(Rhv)",4,"ILE 3 114;LEU 3 104;GLY 3 101;PHE 3  95","None","0.70A","2tsrA-1cov3:0.0","2tsrA-1cov3:20.75"],["2TSR_A_D16A309_1","1gxl","Thermotoga maritima","CHROMOSOME SEGREGATION SMC PROTEIN","PF06470(SMC_hinge)",4,"ILE A 524;LEU A 609;GLY A 610;PHE A 614","None","0.83A","2tsrA-1gxlA:0.0","2tsrA-1gxlA:22.61"],["2TSR_A_D16A309_1","1hv5","Mus musculus","STROMELYSIN 3","PF00413(Peptidase_M10)",4,"ILE A 159;LEU A 225;GLY A 222;PHE A 221","None","0.78A","2tsrA-1hv5A:undetectable","2tsrA-1hv5A:20.66"],["2TSR_A_D16A309_1","1hvy","Homo sapiens","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",6,"ILE A 108;ASP A 218;LEU A 221;GLY A 222;PHE A 225;TYR A 258","D16 A 414 (-3.7A);D16 A 414 ( 3.6A);D16 A 414 (-4.0A);D16 A 414 (-3.3A);D16 A 414 (-3.6A);UMP A 314 ( 4.4A)","0.57A","2tsrA-1hvyA:44.0","2tsrA-1hvyA:92.71"],["2TSR_A_D16A309_1","1ize","Aspergillus oryzae","ASPARTIC PROTEINASE","PF00026(Asp)",5,"ASP A 300;LEU A 303;GLY A 299;PHE A 298;TYR A  17","None","1.16A","2tsrA-1izeA:0.0","2tsrA-1izeA:21.33"],["2TSR_A_D16A309_1","1j3j","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",4,"ASP C 513;LEU C 516;GLY C 517;TYR C 553","UMP C 611 (-4.9A);None;UMP C 611 (-3.5A);UMP C 611 (-4.9A)","0.59A","2tsrA-1j3jC:40.4","2tsrA-1j3jC:50.30"],["2TSR_A_D16A309_1","1j3j","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",4,"ILE C 403;ASP C 513;GLY C 517;TYR C 553","None;UMP C 611 (-4.9A);UMP C 611 (-3.5A);UMP C 611 (-4.9A)","0.42A","2tsrA-1j3jC:40.4","2tsrA-1j3jC:50.30"],["2TSR_A_D16A309_1","1l6j","Homo sapiens","MATRIX METALLOPROTEINASE-9","PF00040(fn2);PF00413(Peptidase_M10);PF01471(PG_binding_1)",4,"ILE A 166;LEU A 407;GLY A 404;PHE A 403","None","0.87A","2tsrA-1l6jA:undetectable","2tsrA-1l6jA:21.63"],["2TSR_A_D16A309_1","1pmj","Caldicellulosiruptor saccharolyticus","BETA-1,4-MANNANASE","PF09212(CBM27)",4,"ILE X 173;ASP X  61;GLY X 164;PHE X 103","None","0.88A","2tsrA-1pmjX:undetectable","2tsrA-1pmjX:20.00"],["2TSR_A_D16A309_1","1rtr","Staphylococcus aureus","GERANYLTRANSTRANSFERASE","PF00348(polyprenyl_synt)",4,"ILE A  45;LEU A 210;GLY A 211;PHE A 214","None","0.52A","2tsrA-1rtrA:undetectable","2tsrA-1rtrA:23.55"],["2TSR_A_D16A309_1","1sch","Arachis hypogaea","PEANUT PEROXIDASE, MAJOR CATIONIC ISOZYME","PF00141(peroxidase)",4,"ILE A 183;ASP A 239;LEU A 235;GLY A 234","None","0.89A","2tsrA-1schA:undetectable","2tsrA-1schA:20.92"],["2TSR_A_D16A309_1","1tis","Escherichia virus T4","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",4,"ASP A 179;GLY A 183;PHE A 186;TYR A 219","None","0.46A","2tsrA-1tisA:30.8","2tsrA-1tisA:41.10"],["2TSR_A_D16A309_1","1tis","Escherichia virus T4","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",4,"ASP A 179;LEU A 182;GLY A 183;TYR A 219","None","0.46A","2tsrA-1tisA:30.8","2tsrA-1tisA:41.10"],["2TSR_A_D16A309_1","1uch","Homo sapiens","UBIQUITIN C-TERMINAL HYDROLASE UCH-L3","PF01088(Peptidase_C12)",4,"ILE A 225;LEU A 100;GLY A  99;PHE A 170","None","0.88A","2tsrA-1uchA:undetectable","2tsrA-1uchA:22.67"],["2TSR_A_D16A309_1","2aaz","Cryptococcus neoformans","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",5,"ILE A 100;ASP A 219;LEU A 222;GLY A 223;TYR A 259","CB3 A2351 (-3.6A);CB3 A2351 ( 3.6A);CB3 A2351 (-4.1A);CB3 A2351 ( 3.2A);CB3 A2351 ( 4.3A)","0.69A","2tsrA-2aazA:undetectable","2tsrA-2aazA:59.19"],["2TSR_A_D16A309_1","2aaz","Cryptococcus neoformans","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",5,"ILE A 100;LEU A 222;GLY A 223;PHE A 226;TYR A 259","CB3 A2351 (-3.6A);CB3 A2351 (-4.1A);CB3 A2351 ( 3.2A);CB3 A2351 (-3.8A);CB3 A2351 ( 4.3A)","1.02A","2tsrA-2aazA:undetectable","2tsrA-2aazA:59.19"],["2TSR_A_D16A309_1","2amy","Homo sapiens","PHOSPHOMANNOMUTASE 2","PF03332(PMM)",4,"ILE A 240;ASP A 209;GLY A 208;PHE A 207","None","0.81A","2tsrA-2amyA:undetectable","2tsrA-2amyA:22.53"],["2TSR_A_D16A309_1","2cb1","Thermus thermophilus","O-ACETYL HOMOSERINE SULFHYDRYLASE","PF01053(Cys_Met_Meta_PP)",4,"LEU A 185;GLY A 180;PHE A 179;TYR A   3","None","0.86A","2tsrA-2cb1A:undetectable","2tsrA-2cb1A:23.22"],["2TSR_A_D16A309_1","2drq","Bacillus halodurans","XYLANASE Y","PF01270(Glyco_hydro_8)",4,"ILE A  87;ASP A  42;GLY A  41;PHE A  40","None","0.89A","2tsrA-2drqA:undetectable","2tsrA-2drqA:20.24"],["2TSR_A_D16A309_1","2h2q","Trypanosoma cruzi","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",5,"ASP A 426;LEU A 429;GLY A 430;PHE A 433;TYR A 466","None;None; DU A 611 (-3.5A);None; DU A 611 (-4.6A)","0.65A","2tsrA-2h2qA:40.5","2tsrA-2h2qA:38.00"],["2TSR_A_D16A309_1","2h2q","Trypanosoma cruzi","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",5,"ILE A 316;ASP A 426;GLY A 430;PHE A 433;TYR A 466","None;None; DU A 611 (-3.5A);None; DU A 611 (-4.6A)","0.41A","2tsrA-2h2qA:40.5","2tsrA-2h2qA:38.00"],["2TSR_A_D16A309_1","2i53","Homo sapiens","CYCLIN K","PF00134(Cyclin_N);PF02984(Cyclin_C)",4,"ILE A 117;ASP A 134;GLY A 133;PHE A 132","None","0.86A","2tsrA-2i53A:undetectable","2tsrA-2i53A:21.30"],["2TSR_A_D16A309_1","2idv","Triticum aestivum","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-1","PF01652(IF4E)",4,"ILE A 166;ASP A 148;GLY A 147;PHE A 144","None","0.77A","2tsrA-2idvA:undetectable","2tsrA-2idvA:18.24"],["2TSR_A_D16A309_1","2ivg","Escherichia coli","CYANATE LYASE","PF02560(Cyanate_lyase)",4,"ILE A 121;ASP A 118;GLY A 117;PHE A 116","None","0.90A","2tsrA-2ivgA:undetectable","2tsrA-2ivgA:20.65"],["2TSR_A_D16A309_1","2o1o","Cryptosporidium parvum","PUTATIVE FARNESYL PYROPHOSPHATE SYNTHASE","PF00348(polyprenyl_synt)",4,"ILE A 355;GLY A 247;PHE A 249;TYR A 214","None","0.78A","2tsrA-2o1oA:undetectable","2tsrA-2o1oA:21.00"],["2TSR_A_D16A309_1","2oip","Cryptosporidium hominis","CHAIN A, CRYSTAL STRUCTURE OF DHFR","PF00186(DHFR_1);PF00303(Thymidylat_synt)",5,"ILE A 315;ASP A 426;LEU A 429;GLY A 430;TYR A 466","CB3 A 604 ( 3.7A);CB3 A 604 ( 3.9A);CB3 A 604 ( 4.4A);CB3 A 604 ( 3.4A);UMP A 603 ( 4.3A)","0.70A","2tsrA-2oipA:41.4","2tsrA-2oipA:35.07"],["2TSR_A_D16A309_1","2tdd","Lactobacillus casei","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",4,"ASP A 221;LEU A 224;GLY A 225;TYR A 261","UFP A 529 (-4.7A);THF A 568 (-3.6A);UFP A 529 ( 4.0A);UFP A 529 (-4.7A)","0.85A","2tsrA-2tddA:33.8","2tsrA-2tddA:43.60"],["2TSR_A_D16A309_1","2tdd","Lactobacillus casei","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",4,"ILE A  81;ASP A 221;GLY A 225;TYR A 261","THF A 568 ( 4.8A);UFP A 529 (-4.7A);UFP A 529 ( 4.0A);UFP A 529 (-4.7A)","0.64A","2tsrA-2tddA:33.8","2tsrA-2tddA:43.60"],["2TSR_A_D16A309_1","2tdd","Lactobacillus casei","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",4,"LEU A 224;GLY A 225;PHE A 228;TYR A 261","THF A 568 (-3.6A);UFP A 529 ( 4.0A);THF A 568 (-4.8A);UFP A 529 (-4.7A)","0.82A","2tsrA-2tddA:33.8","2tsrA-2tddA:43.60"],["2TSR_A_D16A309_1","2vn8","Homo sapiens","RETICULON-4-INTERACTING PROTEIN 1","PF08240(ADH_N);PF13602(ADH_zinc_N_2)",4,"ARG A 103;ILE A  86;LEU A 119;GLY A 120","None","0.79A","2tsrA-2vn8A:undetectable","2tsrA-2vn8A:22.38"],["2TSR_A_D16A309_1","2wed","Penicillium janthinellum","PENICILLOPEPSIN","PF00026(Asp)",5,"ASP A 300;LEU A 303;GLY A 299;PHE A 298;TYR A  17","None","1.20A","2tsrA-2wedA:undetectable","2tsrA-2wedA:20.49"],["2TSR_A_D16A309_1","2wmc","Pisum sativum","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E","PF01652(IF4E)",4,"ILE A 179;ASP A 161;GLY A 160;PHE A 157","None","0.69A","2tsrA-2wmcA:undetectable","2tsrA-2wmcA:17.80"],["2TSR_A_D16A309_1","3bo7","Toxoplasma gondii","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE CYCLOPHILIN-TYPE","PF00160(Pro_isomerase)",4,"ILE A 121;ASP A 144;LEU A 143;GLY A 142","None","0.71A","2tsrA-3bo7A:undetectable","2tsrA-3bo7A:19.43"],["2TSR_A_D16A309_1","3bw2","Streptomyces ansochromogenes","2-NITROPROPANE DIOXYGENASE","PF03060(NMO)",4,"ARG A 329;ILE A  13;GLY A 237;PHE A 240","None;None;FMN A 370 (-3.2A);None","0.88A","2tsrA-3bw2A:undetectable","2tsrA-3bw2A:21.59"],["2TSR_A_D16A309_1","3emy","Trichoderma reesei","TRICHODERMA REESEI ASPARTIC PROTEASE","PF00026(Asp)",5,"ASP A 304;LEU A 307;GLY A 303;PHE A 302;TYR A  14","None","1.14A","2tsrA-3emyA:undetectable","2tsrA-3emyA:19.77"],["2TSR_A_D16A309_1","3heb","Rhodospirillum rubrum","RESPONSE REGULATOR RECEIVER DOMAIN PROTEIN (CHEY)","PF00072(Response_reg)",4,"ILE A  10;LEU A 135;GLY A 136;PHE A 139","None","0.65A","2tsrA-3hebA:undetectable","2tsrA-3hebA:21.33"],["2TSR_A_D16A309_1","3ix6","Brucella melitensis","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",4,"ASP A 169;LEU A 172;GLY A 173;TYR A 209","None","0.77A","2tsrA-3ix6A:33.6","2tsrA-3ix6A:41.58"],["2TSR_A_D16A309_1","3kgb","Encephalitozoon cuniculi","THYMIDYLATE SYNTHASE 1\/2","PF00303(Thymidylat_synt)",4,"LEU A 200;GLY A 201;PHE A 204;TYR A 237","None","0.64A","2tsrA-3kgbA:36.5","2tsrA-3kgbA:57.74"],["2TSR_A_D16A309_1","3kjr","Babesia bovis","DIHYDROFOLATE REDUCTASE\/THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",4,"ASP A 416;LEU A 419;GLY A 420;TYR A 456","None","0.61A","2tsrA-3kjrA:40.9","2tsrA-3kjrA:34.30"],["2TSR_A_D16A309_1","3kq5","Coxiella burnetii","HYPOTHETICAL CYTOSOLIC PROTEIN","PF07515(TraI_2_C)",4,"ILE A 367;LEU A 320;GLY A 319;PHE A 318","None","0.76A","2tsrA-3kq5A:undetectable","2tsrA-3kq5A:23.41"],["2TSR_A_D16A309_1","3o7t","Moniliophthora perniciosa","CYCLOPHILIN A","PF00160(Pro_isomerase)",4,"ILE A 112;ASP A 135;LEU A 134;GLY A 133","None","0.73A","2tsrA-3o7tA:undetectable","2tsrA-3o7tA:18.87"],["2TSR_A_D16A309_1","3o8o","Saccharomyces cerevisiae","6-PHOSPHOFRUCTOKINASE SUBUNIT ALPHA;6-PHOSPHOFRUCTOKINASE SUBUNIT BETA","PF00365(PFK)",4,"ARG B 383;ILE A 355;ASP A 309;GLY A 308","F6P A 988 (-2.3A);F6P A 988 (-4.9A);None;None","0.77A","2tsrA-3o8oB:undetectable","2tsrA-3o8oB:18.57"],["2TSR_A_D16A309_1","3thn","Thermotoga maritima","EXONUCLEASE, PUTATIVE","PF00149(Metallophos)",4,"ILE A 230;ASP A  14;GLY A 233;PHE A 220","None; MN A 360 (-3.4A);None;None","0.79A","2tsrA-3thnA:undetectable","2tsrA-3thnA:20.87"],["2TSR_A_D16A309_1","3tho","Thermotoga maritima","EXONUCLEASE, PUTATIVE","PF00149(Metallophos)",4,"ILE B 230;ASP B  14;GLY B 233;PHE B 220","None; MN B   1 (-3.7A);None;None","0.77A","2tsrA-3thoB:undetectable","2tsrA-3thoB:20.74"],["2TSR_A_D16A309_1","3uca","Clostridium perfringens","GERANYLTRANSTRANSFERASE","PF00348(polyprenyl_synt)",4,"ILE A  54;LEU A 220;GLY A 221;PHE A 224","None","0.76A","2tsrA-3ucaA:undetectable","2tsrA-3ucaA:23.22"],["2TSR_A_D16A309_1","3um6","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",4,"ASP A 513;LEU A 516;GLY A 517;TYR A 553","UMP A 611 (-4.9A);None;UMP A 611 (-3.3A);UMP A 611 (-4.5A)","0.60A","2tsrA-3um6A:40.7","2tsrA-3um6A:28.95"],["2TSR_A_D16A309_1","3um6","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",4,"ILE A 403;ASP A 513;GLY A 517;TYR A 553","None;UMP A 611 (-4.9A);UMP A 611 (-3.3A);UMP A 611 (-4.5A)","0.44A","2tsrA-3um6A:40.7","2tsrA-3um6A:28.95"],["2TSR_A_D16A309_1","3usz","Pseudoalteromonas sp. BB1","EXO-1,3\/1,4-BETA-GLUCANASE","PF00933(Glyco_hydro_3);PF01915(Glyco_hydro_3_C)",4,"ILE A 210;ASP A 287;GLY A 288;PHE A 289","None","0.82A","2tsrA-3uszA:undetectable","2tsrA-3uszA:15.98"],["2TSR_A_D16A309_1","3v8h","Burkholderia thailandensis","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",4,"ASP A 217;GLY A 221;PHE A 224;TYR A 257","None;None;None;CIT A 400 (-4.5A)","0.52A","2tsrA-3v8hA:34.5","2tsrA-3v8hA:34.68"],["2TSR_A_D16A309_1","3v8h","Burkholderia thailandensis","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",4,"LEU A 220;GLY A 221;PHE A 224;TYR A 257","None;None;None;CIT A 400 (-4.5A)","0.79A","2tsrA-3v8hA:34.5","2tsrA-3v8hA:34.68"],["2TSR_A_D16A309_1","3wjo","Escherichia coli","OCTAPRENYL DIPHOSPHATE SYNTHASE","PF00348(polyprenyl_synt)",4,"ILE A  47;LEU A 203;GLY A 204;PHE A 207","None;None;None;IPE A 402 (-4.5A)","0.60A","2tsrA-3wjoA:undetectable","2tsrA-3wjoA:22.28"],["2TSR_A_D16A309_1","4aee","Staphylothermus marinus","ALPHA AMYLASE, CATALYTIC REGION","PF00128(Alpha-amylase)",4,"ILE A 447;LEU A 472;GLY A 470;TYR A 489","None","0.83A","2tsrA-4aeeA:undetectable","2tsrA-4aeeA:17.34"],["2TSR_A_D16A309_1","4dq1","Staphylococcus aureus","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",4,"ASP A 224;LEU A 227;GLY A 228;TYR A 264","None;None;UMP A 501 ( 4.0A);UMP A 501 (-4.2A)","0.74A","2tsrA-4dq1A:34.2","2tsrA-4dq1A:46.43"],["2TSR_A_D16A309_1","4dq1","Staphylococcus aureus","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",5,"ILE A  84;ASP A 224;GLY A 228;PHE A 231;TYR A 264","None;None;UMP A 501 ( 4.0A);None;UMP A 501 (-4.2A)","0.53A","2tsrA-4dq1A:34.2","2tsrA-4dq1A:46.43"],["2TSR_A_D16A309_1","4fog","Mycobacterium tuberculosis","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",4,"ILE A  79;ASP A 169;GLY A 173;TYR A 209","C2F A 302 (-3.3A);C2F A 302 ( 3.9A);C2F A 302 (-3.2A);C2F A 302 ( 4.6A)","0.46A","2tsrA-4fogA:36.8","2tsrA-4fogA:47.88"],["2TSR_A_D16A309_1","4fvl","Homo sapiens","COLLAGENASE 3","PF00045(Hemopexin);PF00413(Peptidase_M10)",4,"ILE A 163;LEU A 228;GLY A 225;PHE A 224","None","0.90A","2tsrA-4fvlA:undetectable","2tsrA-4fvlA:22.25"],["2TSR_A_D16A309_1","4h0u","Corynebacterium glutamicum","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",4,"ASP A 172;LEU A 175;GLY A 176;TYR A 212","None;None;UMP A 301 (-3.6A);UMP A 301 (-4.5A)","0.72A","2tsrA-4h0uA:35.7","2tsrA-4h0uA:46.25"],["2TSR_A_D16A309_1","4h0u","Corynebacterium glutamicum","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",4,"ILE A  82;ASP A 172;GLY A 176;TYR A 212","None;None;UMP A 301 (-3.6A);UMP A 301 (-4.5A)","0.47A","2tsrA-4h0uA:35.7","2tsrA-4h0uA:46.25"],["2TSR_A_D16A309_1","4h1x","Streptococcus pneumoniae","PHOSPHATE-BINDING PROTEIN PSTS 2","PF12849(PBP_like_2)",4,"ILE A 212;LEU A 143;GLY A 144;PHE A 147","None","0.41A","2tsrA-4h1xA:undetectable","2tsrA-4h1xA:20.89"],["2TSR_A_D16A309_1","4iqq","Caenorhabditis elegans","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",6,"ILE A 110;ASP A 220;LEU A 223;GLY A 224;PHE A 227;TYR A 260","D16 A 402 (-4.0A);D16 A 402 ( 4.0A);D16 A 402 (-3.7A);D16 A 402 ( 3.1A);D16 A 402 (-3.2A);D16 A 402 ( 4.2A)","0.22A","2tsrA-4iqqA:43.0","2tsrA-4iqqA:63.29"],["2TSR_A_D16A309_1","4k6l","Salmonella enterica","CYTOLETHAL DISTENDING TOXIN SUBUNIT B HOMOLOG","PF03372(Exo_endo_phos)",4,"ILE F 124;ASP F 131;LEU F 151;GLY F 150","None","0.75A","2tsrA-4k6lF:undetectable","2tsrA-4k6lF:20.06"],["2TSR_A_D16A309_1","4kzs","Helicobacter pylori","LPP20 LIPOFAMILY PROTEIN","PF02169(LPP20)",4,"ILE A 171;ASP A 130;GLY A 127;PHE A 124","None","0.86A","2tsrA-4kzsA:undetectable","2tsrA-4kzsA:20.55"],["2TSR_A_D16A309_1","4myo","Staphylococcus aureus","VIRGINIAMYCIN A ACETYLTRANSFERASE","PF00132(Hexapep)",4,"ARG A 170;ILE A 178;ASP A 124;GLY A 142","None","0.78A","2tsrA-4myoA:undetectable","2tsrA-4myoA:18.79"],["2TSR_A_D16A309_1","4o3s","Homo sapiens","DNA POLYMERASE ETA","PF00817(IMS);PF11799(IMS_C)",4,"ILE A 255;LEU A 278;GLY A 276;PHE A 247","None;None;GOL A 504 (-3.2A);None","0.90A","2tsrA-4o3sA:undetectable","2tsrA-4o3sA:20.00"],["2TSR_A_D16A309_1","4p6v","Vibrio cholerae","NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT A","PF05896(NQRA);PF11973(NQRA_SLBB)",4,"ILE A 239;ASP A 179;LEU A 178;GLY A 177","None","0.90A","2tsrA-4p6vA:undetectable","2tsrA-4p6vA:20.82"],["2TSR_A_D16A309_1","4pph","Lupinus angustifolius","CONGLUTIN GAMMA","PF14541(TAXi_C);PF14543(TAXi_N)",4,"ARG A 193;ILE A 344;GLY A 361;TYR A 319","None","0.87A","2tsrA-4pphA:undetectable","2tsrA-4pphA:19.15"],["2TSR_A_D16A309_1","4prk","Lactobacillus jensenii","4-PHOSPHOERYTHRONATE DEHYDROGENASE","PF00389(2-Hacid_dh);PF02826(2-Hacid_dh_C)",4,"ILE A 157;LEU A 151;GLY A 153;TYR A 189","None","0.89A","2tsrA-4prkA:undetectable","2tsrA-4prkA:21.29"],["2TSR_A_D16A309_1","4rjz","Agrobacterium fabrum","ABC TRANSPORTER, SUBSTRATE BINDING PROTEIN (SUGAR)","PF01547(SBP_bac_1)",4,"ILE A  88;GLY A 136;PHE A 102;TYR A 120","None","0.74A","2tsrA-4rjzA:undetectable","2tsrA-4rjzA:21.31"],["2TSR_A_D16A309_1","4xct","Homo sapiens","MATRIX METALLOPROTEINASE-9,MATRIX METALLOPROTEINASE-9","PF00413(Peptidase_M10)",4,"ILE A 166;LEU A 232;GLY A 229;PHE A 228","None","0.88A","2tsrA-4xctA:undetectable","2tsrA-4xctA:17.82"],["2TSR_A_D16A309_1","4xsc","Human alphaherpesvirus 3","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",5,"ILE A  96;ASP A 206;GLY A 210;PHE A 213;TYR A 246","1PE A1002 (-4.6A);None;BVP A1001 (-3.4A);1PE A1002 (-3.8A);BVP A1001 (-4.5A)","0.28A","2tsrA-4xscA:40.8","2tsrA-4xscA:65.27"],["2TSR_A_D16A309_1","5by6","Trichinella spiralis","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",4,"ASP A 212;LEU A 215;GLY A 216;TYR A 252","None;None;UMP A 401 (-3.5A);UMP A 401 (-4.6A)","0.71A","2tsrA-5by6A:43.0","2tsrA-5by6A:62.99"],["2TSR_A_D16A309_1","5by6","Trichinella spiralis","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",5,"ILE A 102;ASP A 212;GLY A 216;PHE A 219;TYR A 252","DTT A 402 ( 4.3A);None;UMP A 401 (-3.5A);DTT A 402 ( 4.1A);UMP A 401 (-4.6A)","0.41A","2tsrA-5by6A:43.0","2tsrA-5by6A:62.99"],["2TSR_A_D16A309_1","5e3q","Corynebacterium glutamicum","2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATE N-SUCCINYLTRANSFERASE","PF14602(Hexapep_2);PF14789(THDPS_M)",4,"ILE A  89;LEU A  74;GLY A 153;PHE A 170","None","0.77A","2tsrA-5e3qA:undetectable","2tsrA-5e3qA:21.49"],["2TSR_A_D16A309_1","5h3a","Human gammaherpesvirus 8","ORF70","PF00303(Thymidylat_synt)",5,"ILE A 132;ASP A 242;GLY A 246;PHE A 249;TYR A 282","D16 A 401 ( 4.0A);D16 A 401 ( 4.0A);D16 A 401 ( 3.2A);D16 A 401 (-3.4A);UMP A 402 (-4.5A)","0.23A","2tsrA-5h3aA:43.9","2tsrA-5h3aA:70.24"],["2TSR_A_D16A309_1","5hct","Cryphonectria parasitica","ENDOTHIAPEPSIN","PF00026(Asp)",5,"ASP A 307;LEU A 310;GLY A 306;PHE A 305;TYR A  17","None","1.12A","2tsrA-5hctA:undetectable","2tsrA-5hctA:19.21"],["2TSR_A_D16A309_1","5iai","Agrobacterium tumefaciens","SUGAR ABC TRANSPORTER","PF01547(SBP_bac_1)",4,"ILE A 131;LEU A 139;GLY A 140;PHE A 149","None","0.85A","2tsrA-5iaiA:undetectable","2tsrA-5iaiA:20.61"],["2TSR_A_D16A309_1","5iw7","Saccharomyces cerevisiae","RIBOSOME BIOGENESIS PROTEIN TSR1,RIBOSOME BIOGENESIS PROTEIN TSR1","PF04950(RIBIOP_C);PF08142(AARP2CN)",4,"ILE A 177;LEU A 162;GLY A 161;PHE A 160","None","0.75A","2tsrA-5iw7A:undetectable","2tsrA-5iw7A:18.39"],["2TSR_A_D16A309_1","5j7w","Enterococcus faecalis","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",5,"ASP A 220;LEU A 223;GLY A 224;PHE A 227;TYR A 260","None","0.76A","2tsrA-5j7wA:33.9","2tsrA-5j7wA:47.54"],["2TSR_A_D16A309_1","5j7w","Enterococcus faecalis","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",4,"ILE A  80;ASP A 220;PHE A 227;TYR A 260","None","0.65A","2tsrA-5j7wA:33.9","2tsrA-5j7wA:47.54"],["2TSR_A_D16A309_1","5k0u","Rhinovirus C","CAPSID PROTEIN VP3","PF00073(Rhv)",4,"ILE B 112;LEU B 102;GLY B  99;PHE B  93","None","0.86A","2tsrA-5k0uB:undetectable","2tsrA-5k0uB:22.36"],["2TSR_A_D16A309_1","5mac","Methanococcoides burtonii","RIBULOSE-1,5-BISPHOSPHATE CARBOXYLASE-OXYGENASE TYPE III","PF00016(RuBisCO_large);PF02788(RuBisCO_large_N)",4,"ARG A 151;ILE A 397;GLY A 163;PHE A 191","None;None;None;KCX A 193 ( 4.8A)","0.89A","2tsrA-5macA:undetectable","2tsrA-5macA:21.61"],["2TSR_A_D16A309_1","5min","Acinetobacter calcoaceticus","QUINOPROTEIN GLUCOSE DEHYDROGENASE B","no annotation",4,"ILE A  94;LEU A 149;GLY A  81;PHE A  82","None","0.73A","2tsrA-5minA:undetectable","2tsrA-5minA:15.21"],["2TSR_A_D16A309_1","5p60","Cryphonectria parasitica","ENDOTHIAPEPSIN","PF00026(Asp)",5,"ASP A 307;LEU A 310;GLY A 306;PHE A 305;TYR A  17","None","1.11A","2tsrA-5p60A:undetectable","2tsrA-5p60A:18.57"],["2TSR_A_D16A309_1","5sy5","Mus musculus","NEURONAL PAS DOMAIN-CONTAINING PROTEIN 1","PF00010(HLH);PF00989(PAS);PF08447(PAS_3)",4,"ILE B 271;ASP B 147;GLY B 148;PHE B 149","None","0.83A","2tsrA-5sy5B:undetectable","2tsrA-5sy5B:20.81"],["2TSR_A_D16A309_1","5sy7","Mus musculus","NEURONAL PAS DOMAIN-CONTAINING PROTEIN 3","PF00010(HLH);PF00989(PAS);PF08447(PAS_3)",4,"ILE B 291;ASP B 164;GLY B 165;PHE B 166","None","0.72A","2tsrA-5sy7B:undetectable","2tsrA-5sy7B:21.84"],["2TSR_A_D16A309_1","5t0l","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",6,"ARG A 603;ILE A 402;ASP A 513;LEU A 516;GLY A 517;PHE A 520","CB3 A 703 (-3.2A);CB3 A 703 (-3.4A);CB3 A 703 ( 3.8A);CB3 A 703 (-3.7A);CB3 A 703 ( 3.0A);CB3 A 703 (-3.8A)","0.94A","2tsrA-5t0lA:42.3","2tsrA-5t0lA:34.63"],["2TSR_A_D16A309_1","5t0l","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",6,"ILE A 402;ASP A 513;LEU A 516;GLY A 517;PHE A 520;TYR A 553","CB3 A 703 (-3.4A);CB3 A 703 ( 3.8A);CB3 A 703 (-3.7A);CB3 A 703 ( 3.0A);CB3 A 703 (-3.8A);UMP A 701 (-4.4A)","0.44A","2tsrA-5t0lA:42.3","2tsrA-5t0lA:34.63"],["2TSR_A_D16A309_1","5th6","Homo sapiens","MATRIX METALLOPROTEINASE-9,MATRIX METALLOPROTEINASE-9","PF00413(Peptidase_M10);PF01471(PG_binding_1)",4,"ILE A 166;LEU A 407;GLY A 404;PHE A 403","None","0.88A","2tsrA-5th6A:undetectable","2tsrA-5th6A:21.70"],["2TSR_A_D16A309_1","5tw1","Mycolicibacterium smegmatis","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","PF00562(RNA_pol_Rpb2_6);PF04560(RNA_pol_Rpb2_7);PF04561(RNA_pol_Rpb2_2);PF04563(RNA_pol_Rpb2_1);PF04565(RNA_pol_Rpb2_3);PF10385(RNA_pol_Rpb2_45)",4,"ILE C 627;LEU C  44;GLY C  43;TYR C 494","None","0.84A","2tsrA-5tw1C:undetectable","2tsrA-5tw1C:12.82"],["2TSR_A_D16A309_1","5twt","Panicum virgatum","PEROXIDASE PVI9","PF00141(peroxidase)",4,"ILE A 181;ASP A 236;LEU A 232;GLY A 231","None","0.85A","2tsrA-5twtA:undetectable","2tsrA-5twtA:21.01"],["2TSR_A_D16A309_1","5vt9","Toxoplasma gondii","MYOSIN LIGHT CHAIN TGMLC1","no annotation",4,"ILE A 199;LEU A 174;GLY A 171;TYR A 177","None","0.86A","2tsrA-5vt9A:undetectable","2tsrA-5vt9A:22.95"],["2TSR_A_D16A309_1","5y09","Arabidopsis thaliana","PROTEASE DO-LIKE 9","no annotation",4,"ILE A 314;ASP A 222;GLY A 221;PHE A 220","None","0.90A","2tsrA-5y09A:undetectable","2tsrA-5y09A:20.83"],["2TSR_A_D16A309_1","5z9s","Bifidobacterium longum","GLYCOSYL HYDROLASE FAMILY 3 PROTEIN","no annotation",4,"ILE A 279;ASP A  95;LEU A  67;GLY A  94","None","0.85A","2tsrA-5z9sA:undetectable","2tsrA-5z9sA:13.88"],["2TSR_A_D16A309_1","6auj","Elizabethkingia anophelis","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",5,"ILE A  87;ASP A 177;GLY A 181;PHE A 184;TYR A 217","PGE A 301 ( 4.2A);None;PGE A 301 ( 4.0A);PGE A 301 (-3.7A);None","0.54A","2tsrA-6aujA:34.3","2tsrA-6aujA:49.68"],["2TSR_A_D16A309_1","6cdz","Escherichia coli","THYMIDYLATE SYNTHASE","no annotation",5,"ILE A  79;ASP A 169;GLY A 173;PHE A 176;TYR A 209","CB3 A 701 (-3.9A);CB3 A 701 ( 3.6A);CB3 A 701 (-3.3A);CB3 A 701 (-3.8A);UMP A 702 ( 4.2A)","0.33A","2tsrA-6cdzA:37.0","2tsrA-6cdzA:39.81"],["2TSR_A_D16A309_1","6cdz","Escherichia coli","THYMIDYLATE SYNTHASE","no annotation",5,"ILE A  79;LEU A 172;GLY A 173;PHE A 176;TYR A 209","CB3 A 701 (-3.9A);CB3 A 701 (-3.5A);CB3 A 701 (-3.3A);CB3 A 701 (-3.8A);UMP A 702 ( 4.2A)","0.48A","2tsrA-6cdzA:37.0","2tsrA-6cdzA:39.81"]]