SIMILAR PATTERNS OF AMINO ACIDS FOR 2ROX_A_T44A128_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aog TRYPANOTHIONE
REDUCTASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LYS A 414
LEU A 235
ALA A 413
LEU A 430
 None
 1.45A 2roxA-1aogA:
undetectable		 2roxA-1aogA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dly HEMOGLOBIN

(Chlamydomonas
moewusii) 		PF01152
(Bac_globin) 		4 LYS A   5
LEU A   2
ALA A   4
LEU A  53
 SO4  A 123 ( 4.0A)
SO4  A 123 (-4.5A)
None
None
 1.30A 2roxA-1dlyA:
undetectable		 2roxA-1dlyA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		4 LYS A  81
LEU A  78
ALA A  80
LEU A  75
 None
 1.00A 2roxA-1eb3A:
undetectable		 2roxA-1eb3A:
14.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
 None
 0.73A 2roxA-1gkeA:
22.2		 2roxA-1gkeA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH

(Escherichia
coli) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		4 LYS A 139
LEU A 134
ALA A 142
LEU A 109
 None
 1.18A 2roxA-1gz0A:
0.0		 2roxA-1gz0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		4 LYS A 119
LEU A  79
ALA A 118
LEU A 125
 None
 1.33A 2roxA-1iugA:
undetectable		 2roxA-1iugA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl7 MONOMER HEMOGLOBIN
COMPONENT III

(Glycera
dibranchiata) 		PF00042
(Globin) 		4 LYS A  61
LEU A  58
ALA A  60
LEU A  31
 None
CYN  A 149 ( 3.5A)
None
None
 1.46A 2roxA-1jl7A:
undetectable		 2roxA-1jl7A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p99 HYPOTHETICAL PROTEIN
PG110

(Staphylococcus
aureus) 		PF03180
(Lipoprotein_9) 		4 LYS A  55
LEU A  59
ALA A 264
LEU A 258
 None
 1.37A 2roxA-1p99A:
undetectable		 2roxA-1p99A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdb CYTOCHROME C NITRITE
REDUCTASE

(Sulfurospirillum
deleyianum) 		PF02335
(Cytochrom_C552) 		4 LYS A 454
LEU A  76
ALA A 457
LEU A  82
 None
 1.38A 2roxA-1qdbA:
0.0		 2roxA-1qdbA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1n FERRIC-IRON BINDING
PROTEIN

(Neisseria
gonorrhoeae) 		PF01547
(SBP_bac_1) 		4 LYS A 163
LEU A 159
ALA A 306
LEU A 302
 None
 1.32A 2roxA-1r1nA:
0.0		 2roxA-1r1nA:
18.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
 None
 0.48A 2roxA-1sn2A:
20.5		 2roxA-1sn2A:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II

(Homo sapiens) 		PF00106
(adh_short) 		4 LYS A 229
LEU A 253
ALA A 234
LEU A 236
 None
 1.50A 2roxA-1so8A:
undetectable		 2roxA-1so8A:
22.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
 None
 0.36A 2roxA-1tfpA:
19.4		 2roxA-1tfpA:
73.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uvx GLOBIN LI637

(Chlamydomonas
moewusii) 		PF01152
(Bac_globin) 		4 LYS A   5
LEU A   2
ALA A   4
LEU A  53
 None
 1.32A 2roxA-1uvxA:
undetectable		 2roxA-1uvxA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvy SFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 LYS A 163
LEU A 159
ALA A 306
LEU A 302
 None
 1.33A 2roxA-1xvyA:
undetectable		 2roxA-1xvyA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckx TELOMERE BINDING
PROTEIN TBP1

(Nicotiana
tabacum) 		PF00249
(Myb_DNA-binding) 		4 LYS A 604
LEU A 619
ALA A 607
LEU A 588
 None
 1.31A 2roxA-2ckxA:
undetectable		 2roxA-2ckxA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e80 CYTOCHROME C-552

(Wolinella
succinogenes) 		PF02335
(Cytochrom_C552) 		4 LYS A 448
LEU A  77
ALA A 451
LEU A  83
 None
 1.39A 2roxA-2e80A:
undetectable		 2roxA-2e80A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esr METHYLTRANSFERASE

(Streptococcus
pyogenes) 		PF03602
(Cons_hypoth95) 		4 LYS A 135
LEU A 137
ALA A 134
LEU A 138
 None
 1.39A 2roxA-2esrA:
undetectable		 2roxA-2esrA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqi RAS
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00018
(SH3_1) 		4 LYS A  29
LEU A  14
ALA A  12
LEU A  61
 None
 1.27A 2roxA-2gqiA:
undetectable		 2roxA-2gqiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8o GERANYLTRANSTRANSFER
ASE

(Agrobacterium
fabrum) 		PF00348
(polyprenyl_synt) 		4 LYS A 319
LEU A  99
ALA A 321
LEU A 323
 None
 1.33A 2roxA-2h8oA:
undetectable		 2roxA-2h8oA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'

(Homo sapiens) 		PF03095
(PTPA) 		4 LYS A 183
LEU A  78
ALA A 179
LEU A  77
 None
 1.46A 2roxA-2ixmA:
undetectable		 2roxA-2ixmA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkn AH
RECEPTOR-INTERACTING
PROTEIN

(Homo sapiens) 		PF00254
(FKBP_C) 		4 LYS A 103
LEU A 100
ALA A 102
LEU A  97
 None
 1.40A 2roxA-2lknA:
undetectable		 2roxA-2lknA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvq SMALL S PROTEIN

(Podospora
anserina) 		PF14479
(HeLo) 		4 LYS A 218
LEU A 197
ALA A 214
LEU A 200
 None
 1.40A 2roxA-2wvqA:
undetectable		 2roxA-2wvqA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x49 INVASION PROTEIN
INVA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		4 LYS A 512
LEU A 509
ALA A 511
LEU A 517
 None
 1.36A 2roxA-2x49A:
undetectable		 2roxA-2x49A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 LYS A 283
LEU A 306
ALA A 281
LEU A 278
 None
 1.44A 2roxA-2zxoA:
undetectable		 2roxA-2zxoA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edu SPECTRIN BETA CHAIN,
ERYTHROCYTE

(Homo sapiens) 		PF00435
(Spectrin) 		4 LYS A1870
LEU A1799
ALA A1871
LEU A1862
 None
 1.33A 2roxA-3eduA:
undetectable		 2roxA-3eduA:
21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
 0.81A 2roxA-3fc8A:
23.2		 2roxA-3fc8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LYS A 179
LEU A 175
ALA A 178
LEU A 174
 None
 1.25A 2roxA-3gd5A:
undetectable		 2roxA-3gd5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h32 FIBRINOGEN BETA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 LYS B 323
LEU B 311
ALA B 324
LEU B 310
 None
 1.49A 2roxA-3h32B:
undetectable		 2roxA-3h32B:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH

(Streptomyces
glaucescens) 		PF13416
(SBP_bac_8) 		4 LYS A 159
LEU A 220
ALA A 162
LEU A 174
 None
 1.48A 2roxA-3jzjA:
undetectable		 2roxA-3jzjA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwu MUNC13-1

(Rattus
norvegicus) 		PF00168
(C2) 		4 LYS A 704
LEU A 778
ALA A 703
LEU A 701
 CL  A 911 ( 3.2A)
None
None
None
 1.47A 2roxA-3kwuA:
2.5		 2roxA-3kwuA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 LYS A 351
LEU A 265
ALA A 350
LEU A 248
 None
 1.41A 2roxA-3ldrA:
undetectable		 2roxA-3ldrA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		4 LYS A 144
LEU A 171
ALA A 145
LEU A 167
 None
 1.42A 2roxA-3mjoA:
undetectable		 2roxA-3mjoA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwo MOTAVIZUMAB EPITOPE
SCAFFOLD

(Staphylococcus
aureus) 		PF02216
(B) 		4 LYS C  49
LEU C  45
ALA C  48
LEU C  44
 None
 1.47A 2roxA-3qwoC:
undetectable		 2roxA-3qwoC:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb5 NA/CA EXCHANGE
PROTEIN

(Drosophila
melanogaster) 		PF03160
(Calx-beta) 		4 LYS A 656
LEU A 653
ALA A 655
LEU A 647
 None
 1.32A 2roxA-3rb5A:
2.4		 2roxA-3rb5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 LYS A 169
LEU A 166
ALA A 168
LEU A 268
 None
 1.29A 2roxA-3s29A:
undetectable		 2roxA-3s29A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 4 LYS B 761
LEU B 757
ALA B 760
LEU B 754
 None
 1.44A 2roxA-3tixB:
undetectable		 2roxA-3tixB:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 LYS A 143
LEU A  83
ALA A 142
LEU A  82
 None
 1.29A 2roxA-4a1oA:
undetectable		 2roxA-4a1oA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2q ATP SYNTHASE SUBUNIT
DELTA, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF02823
(ATP-synt_DE_N) 		4 LYS H 109
LEU H 105
ALA H 108
LEU H 104
 None
 1.47A 2roxA-4b2qH:
undetectable		 2roxA-4b2qH:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dez DNA POLYMERASE IV 1

(Mycolicibacterium
smegmatis) 		PF00817
(IMS) 		4 LYS A 230
LEU A 226
ALA A 229
LEU A 225
 None
 1.29A 2roxA-4dezA:
undetectable		 2roxA-4dezA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe3 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		4 LYS A 280
LEU A 277
ALA A 279
LEU A 273
 None
 1.30A 2roxA-4pe3A:
undetectable		 2roxA-4pe3A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Rhizobium etli) 		PF13407
(Peripla_BP_4) 		4 LYS A 305
LEU A 311
ALA A 303
LEU A 262
 None
 1.50A 2roxA-4ry0A:
undetectable		 2roxA-4ry0A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Shewanella
loihica) 		PF01156
(IU_nuc_hydro) 		4 LYS A 296
LEU A 299
ALA A 292
LEU A 340
 None
 1.32A 2roxA-4wr2A:
undetectable		 2roxA-4wr2A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcp NEMATODE FATTY ACID
RETINOID BINDING
PROTEIN

(Necator
americanus) 		PF05823
(Gp-FAR-1) 		4 LYS A  62
LEU A  59
ALA A  61
LEU A  52
 None
None
None
PLM  A 202 ( 4.2A)
 1.35A 2roxA-4xcpA:
undetectable		 2roxA-4xcpA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LYS A 312
LEU A 362
ALA A 308
LEU A 365
 None
 1.02A 2roxA-4xvxA:
undetectable		 2roxA-4xvxA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yod THIOREDOXIN-LIKE
PROTEIN

(Bacteroides
caccae) 		PF13905
(Thioredoxin_8)
PF17127
(DUF5106) 		4 LYS A 292
LEU A 202
ALA A 179
LEU A 204
 None
 1.29A 2roxA-4yodA:
undetectable		 2roxA-4yodA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B

(Homo sapiens) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 LYS A 439
LEU A 436
ALA A 438
LEU A 420
 None
 1.42A 2roxA-5dseA:
undetectable		 2roxA-5dseA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		4 LYS A 633
LEU A 629
ALA A 632
LEU A 628
 None
 1.43A 2roxA-5h2vA:
undetectable		 2roxA-5h2vA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hss LINALOOL
DEHYDRATASE/ISOMERAS
E

(Castellaniella
defragrans) 		no annotation 4 LYS A 350
LEU A 346
ALA A 349
LEU A 345
 None
 1.45A 2roxA-5hssA:
undetectable		 2roxA-5hssA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsb MCL-1 INHIBITOR

(synthetic
construct) 		no annotation 4 LYS B  68
LEU B  92
ALA B  71
LEU B   7
 None
 1.33A 2roxA-5jsbB:
undetectable		 2roxA-5jsbB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k57 PROTEIN DDI1 HOMOLOG
2

(Homo sapiens) 		no annotation 4 LYS A  39
LEU A  35
ALA A  46
LEU A  28
 None
 1.43A 2roxA-5k57A:
undetectable		 2roxA-5k57A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvr PYRUVATE
DEHYDROGENASE
COMPLEX REPRESSOR

(Escherichia
coli) 		PF00392
(GntR) 		4 LYS A  61
LEU A  58
ALA A  60
LEU A  64
 None
 1.26A 2roxA-5kvrA:
undetectable		 2roxA-5kvrA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ave ACID-SENSING ION
CHANNEL 1

(Gallus gallus) 		no annotation 4 LYS A 142
LEU A 109
ALA A 143
LEU A 119
 None
 1.40A 2roxA-6aveA:
2.7		 2roxA-6aveA:
21.88