SIMILAR PATTERNS OF AMINO ACIDS FOR 2RLF_D_RIMD499

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		4 ILE A  27
LEU A  29
LEU A 240
ASP A 237
 None
 1.08A 2rlfA-1cs1A:
0.0
2rlfD-1cs1A:
0.0		 2rlfA-1cs1A:
7.47
2rlfD-1cs1A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1db3 GDP-MANNOSE
4,6-DEHYDRATASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		4 ILE A 304
ARG A 259
LEU A 273
LEU A 217
 None
 0.69A 2rlfA-1db3A:
0.0
2rlfD-1db3A:
0.0		 2rlfA-1db3A:
9.76
2rlfD-1db3A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl3 PROTEIN
(PHOSPHORIBOSYLANTRA
NILATE ISOMERASE)

(Thermotoga
maritima) 		PF00697
(PRAI) 		4 ILE A 144
ARG A 148
LEU A 145
LEU A 156
 None
 1.06A 2rlfA-1dl3A:
0.0
2rlfD-1dl3A:
0.0		 2rlfA-1dl3A:
13.93
2rlfD-1dl3A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		4 TRP A 504
ILE A 503
LEU A 321
LEU A   3
 None
 1.06A 2rlfA-1gzvA:
0.0
2rlfD-1gzvA:
0.0		 2rlfA-1gzvA:
6.42
2rlfD-1gzvA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihp PHYTASE

(Aspergillus
ficuum) 		PF00328
(His_Phos_2) 		4 ILE A 177
LEU A 187
LEU A 319
ASP A 320
 None
 1.06A 2rlfA-1ihpA:
0.0
2rlfD-1ihpA:
undetectable		 2rlfA-1ihpA:
9.12
2rlfD-1ihpA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2m 17-KDA
PKC-POTENTIATED
INHIBITORY PROTEIN
OF PP1

(Sus scrofa) 		PF05361
(PP1_inhibitor) 		4 ILE A  35
ARG A  38
LEU A  39
LEU A  90
 None
 1.07A 2rlfA-1j2mA:
0.0
2rlfD-1j2mA:
0.0		 2rlfA-1j2mA:
15.15
2rlfD-1j2mA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 ILE A 676
ARG A 587
LEU A 591
LEU A 669
 None
 1.03A 2rlfA-1kblA:
0.0
2rlfD-1kblA:
0.0		 2rlfA-1kblA:
4.60
2rlfD-1kblA:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 ILE A  28
ARG A  25
LEU A  24
LEU A  96
 None
 1.06A 2rlfA-1ldjA:
0.0
2rlfD-1ldjA:
0.0		 2rlfA-1ldjA:
5.47
2rlfD-1ldjA:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Ovis aries) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 ILE A  97
ARG A 111
LEU A 115
LEU A  72
 None
 0.96A 2rlfA-1pgpA:
0.0
2rlfD-1pgpA:
0.0		 2rlfA-1pgpA:
7.17
2rlfD-1pgpA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qap QUINOLINIC ACID
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 ILE A 232
LEU A 234
LEU A 225
ASP A 222
 None
 1.07A 2rlfA-1qapA:
undetectable
2rlfD-1qapA:
undetectable		 2rlfA-1qapA:
9.25
2rlfD-1qapA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE

(Escherichia
coli) 		PF02441
(Flavoprotein) 		4 ILE A  94
ARG A  95
LEU A  91
LEU A 111
 None
 1.07A 2rlfA-1sbzA:
undetectable
2rlfD-1sbzA:
undetectable		 2rlfA-1sbzA:
14.02
2rlfD-1sbzA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)

(Archaeoglobus
fulgidus) 		PF01888
(CbiD) 		4 ILE A 251
LEU A 258
LEU A 243
ASP A 240
 None
 1.02A 2rlfA-1sr8A:
undetectable
2rlfD-1sr8A:
undetectable		 2rlfA-1sr8A:
11.87
2rlfD-1sr8A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF02358
(Trehalose_PPase) 		4 ILE A  32
ARG A 216
LEU A 219
LEU A  56
 None
 0.99A 2rlfA-1u02A:
undetectable
2rlfD-1u02A:
undetectable		 2rlfA-1u02A:
10.91
2rlfD-1u02A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0m ENDO-1,4-BETA-XYLANA
SE A

(Streptomyces
lividans) 		PF00331
(Glyco_hydro_10) 		4 ILE A  20
ARG A  24
LEU A  25
ASP A 272
 None
 0.85A 2rlfA-1v0mA:
undetectable
2rlfD-1v0mA:
undetectable		 2rlfA-1v0mA:
8.70
2rlfD-1v0mA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0g ISCA

(Thermosynechococcus
elongatus) 		PF01521
(Fe-S_biosyn) 		4 ILE A  27
ARG A  29
LEU A  56
ASP A  54
 None
 1.03A 2rlfA-1x0gA:
undetectable
2rlfD-1x0gA:
undetectable		 2rlfA-1x0gA:
17.17
2rlfD-1x0gA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ILE A 871
ARG A 870
LEU A 762
LEU A1009
 None
 1.05A 2rlfA-1yq2A:
undetectable
2rlfD-1yq2A:
undetectable		 2rlfA-1yq2A:
3.42
2rlfD-1yq2A:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjr MFP2B

(Ascaris suum) 		PF12150
(MFP2b) 		4 ILE A 163
ARG A 165
LEU A  80
ASP A   9
 None
 1.03A 2rlfA-2bjrA:
undetectable
2rlfD-2bjrA:
undetectable		 2rlfA-2bjrA:
15.98
2rlfD-2bjrA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bju PLASMEPSIN II

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 ILE A 139
LEU A 124
LEU A 143
ASP A   4
 None
 1.06A 2rlfA-2bjuA:
undetectable
2rlfD-2bjuA:
undetectable		 2rlfA-2bjuA:
6.32
2rlfD-2bjuA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckr ENDOGLUCANASE E-5

(Thermobifida
fusca) 		PF00150
(Cellulase) 		4 ILE A 184
ARG A 216
LEU A 175
LEU A 209
 None
ZN  A1433 ( 4.7A)
None
None
 1.08A 2rlfA-2ckrA:
undetectable
2rlfD-2ckrA:
undetectable		 2rlfA-2ckrA:
10.76
2rlfD-2ckrA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy4 EPIDERMAL GROWTH
FACTOR RECEPTOR
PATHWAY SUBSTRATE
8-LIKE PROTEIN 1

(Mus musculus) 		PF08416
(PTB) 		4 ILE A 151
ARG A 148
LEU A 120
LEU A 155
 None
 0.92A 2rlfA-2cy4A:
undetectable
2rlfD-2cy4A:
undetectable		 2rlfA-2cy4A:
11.43
2rlfD-2cy4A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejx STK_08120

(Sulfurisphaera
tokodaii) 		PF11485
(DUF3211) 		4 ILE A  85
ARG A  86
LEU A  93
LEU A  83
 None
 1.07A 2rlfA-2ejxA:
undetectable
2rlfD-2ejxA:
undetectable		 2rlfA-2ejxA:
16.67
2rlfD-2ejxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Porphyromonas
gingivalis) 		PF04095
(NAPRTase) 		4 ILE A   4
ARG A   5
LEU A  60
LEU A 173
 None
 0.87A 2rlfA-2im5A:
undetectable
2rlfD-2im5A:
undetectable		 2rlfA-2im5A:
7.44
2rlfD-2im5A:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lr8 CASP8-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		no annotation 4 ILE A  25
ARG A  56
LEU A  60
LEU A  46
 None
 0.91A 2rlfA-2lr8A:
undetectable
2rlfD-2lr8A:
undetectable		 2rlfA-2lr8A:
18.84
2rlfD-2lr8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m4e PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio
vulnificus) 		PF16691
(DUF5062) 		4 ILE A  67
ARG A  70
LEU A  71
LEU A  62
 None
 0.81A 2rlfA-2m4eA:
undetectable
2rlfD-2m4eA:
undetectable		 2rlfA-2m4eA:
14.55
2rlfD-2m4eA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mab ACINIFORM SPIDROIN

(Nephila
antipodiana) 		PF11260
(Spidroin_MaSp) 		4 ILE A  22
ARG A  21
LEU A  25
LEU A  13
 None
 1.07A 2rlfA-2mabA:
undetectable
2rlfD-2mabA:
undetectable		 2rlfA-2mabA:
14.68
2rlfD-2mabA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ILE A  13
ARG A  15
LEU A  16
LEU A   9
 None
 0.91A 2rlfA-2ng1A:
undetectable
2rlfD-2ng1A:
undetectable		 2rlfA-2ng1A:
10.20
2rlfD-2ng1A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE

(Homo sapiens) 		PF01053
(Cys_Met_Meta_PP) 		4 ILE A  41
LEU A  43
LEU A 254
ASP A 251
 None
 1.02A 2rlfA-2nmpA:
undetectable
2rlfD-2nmpA:
undetectable		 2rlfA-2nmpA:
8.84
2rlfD-2nmpA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA

(Escherichia
coli) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 ILE A  68
ARG A  64
LEU A  65
LEU A  74
 None
 1.04A 2rlfA-2nqnA:
undetectable
2rlfD-2nqnA:
undetectable		 2rlfA-2nqnA:
7.09
2rlfD-2nqnA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C

(Saccharomyces
cerevisiae) 		PF16796
(Microtub_bd) 		4 ILE A 461
ARG A 457
LEU A 460
LEU A 530
 None
 1.02A 2rlfA-2o0aA:
undetectable
2rlfD-2o0aA:
undetectable		 2rlfA-2o0aA:
10.57
2rlfD-2o0aA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o62 HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		PF12204
(DUF3598) 		4 ILE A 194
ARG A 176
LEU A 171
ASP A 172
 None
GOL  A 273 ( 4.8A)
None
None
 1.08A 2rlfA-2o62A:
undetectable
2rlfD-2o62A:
undetectable		 2rlfA-2o62A:
11.06
2rlfD-2o62A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 ILE A  97
ARG A 111
LEU A 115
LEU A  72
 None
 0.83A 2rlfA-2p4qA:
undetectable
2rlfD-2p4qA:
undetectable		 2rlfA-2p4qA:
6.95
2rlfD-2p4qA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rqx POLYMYXIN B
RESISTANCE PROTEIN

(Klebsiella
pneumoniae) 		PF11183
(PmrD) 		4 ILE A  65
ARG A  52
LEU A  63
ASP A  50
 None
 1.05A 2rlfA-2rqxA:
undetectable
2rlfD-2rqxA:
undetectable		 2rlfA-2rqxA:
19.54
2rlfD-2rqxA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0s PYRUVATE PHOSPHATE
DIKINASE

(Trypanosoma
brucei) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 ILE A 701
ARG A 612
LEU A 616
LEU A 694
 None
 1.07A 2rlfA-2x0sA:
undetectable
2rlfD-2x0sA:
undetectable		 2rlfA-2x0sA:
4.37
2rlfD-2x0sA:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7v PROBABLE
ENDONUCLEASE 4

(Thermotoga
maritima) 		PF01261
(AP_endonuc_2) 		4 ILE A 163
ARG A 164
LEU A 160
LEU A 129
 None
 1.05A 2rlfA-2x7vA:
undetectable
2rlfD-2x7vA:
undetectable		 2rlfA-2x7vA:
11.43
2rlfD-2x7vA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 ILE A 463
ARG A 509
LEU A 506
ASP A 468
 None
 1.00A 2rlfA-2yfnA:
undetectable
2rlfD-2yfnA:
undetectable		 2rlfA-2yfnA:
6.58
2rlfD-2yfnA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE

(Escherichia
coli) 		PF03588
(Leu_Phe_trans) 		4 ILE A 202
ARG A  64
LEU A 184
ASP A 186
 None
 1.00A 2rlfA-2z3kA:
undetectable
2rlfD-2z3kA:
undetectable		 2rlfA-2z3kA:
14.29
2rlfD-2z3kA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z51 NIFU-LIKE PROTEIN 2,
CHLOROPLAST

(Arabidopsis
thaliana) 		PF01106
(NifU) 		4 ILE A  59
ARG A  62
LEU A  63
LEU A  20
 None
 0.93A 2rlfA-2z51A:
undetectable
2rlfD-2z51A:
undetectable		 2rlfA-2z51A:
14.39
2rlfD-2z51A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Klebsiella
pneumoniae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 ILE A  97
ARG A 111
LEU A 115
LEU A  72
 None
 1.01A 2rlfA-2zygA:
undetectable
2rlfD-2zygA:
undetectable		 2rlfA-2zygA:
6.67
2rlfD-2zygA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqh PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB

(Neisseria
meningitidis) 		PF01625
(PMSR) 		4 ILE A 305
LEU A 309
LEU A 263
ASP A 264
 None
 0.95A 2rlfA-3bqhA:
undetectable
2rlfD-3bqhA:
undetectable		 2rlfA-3bqhA:
12.17
2rlfD-3bqhA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpg UNCHARACTERIZED
PROTEIN

(Bifidobacterium
adolescentis) 		PF01168
(Ala_racemase_N) 		4 ILE A 150
ARG A 153
LEU A 132
LEU A 146
 None
 1.04A 2rlfA-3cpgA:
undetectable
2rlfD-3cpgA:
undetectable		 2rlfA-3cpgA:
8.87
2rlfD-3cpgA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg7 MUCONATE
CYCLOISOMERASE

(Mycolicibacterium
smegmatis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 355
LEU A  33
LEU A 332
ASP A 330
 None
 1.04A 2rlfA-3dg7A:
undetectable
2rlfD-3dg7A:
undetectable		 2rlfA-3dg7A:
8.64
2rlfD-3dg7A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkq PKHD-TYPE
HYDROXYLASE
SBAL_3634

(Shewanella
baltica) 		PF13640
(2OG-FeII_Oxy_3) 		4 ILE A  60
ARG A  63
LEU A  64
LEU A  17
 None
 0.89A 2rlfA-3dkqA:
undetectable
2rlfD-3dkqA:
undetectable		 2rlfA-3dkqA:
11.96
2rlfD-3dkqA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 TRP A 995
ILE A1029
LEU A 997
LEU A1031
 None
 1.03A 2rlfA-3ecqA:
undetectable
2rlfD-3ecqA:
undetectable		 2rlfA-3ecqA:
2.83
2rlfD-3ecqA:
2.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ILE A 103
LEU A 172
LEU A 121
ASP A 134
 None
 1.01A 2rlfA-3gm8A:
undetectable
2rlfD-3gm8A:
undetectable		 2rlfA-3gm8A:
4.77
2rlfD-3gm8A:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwz CATABOLITE
ACTIVATION-LIKE
PROTEIN

(Xanthomonas
campestris) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		4 ILE A 133
ARG A 132
LEU A  22
LEU A 126
 None
 0.99A 2rlfA-3iwzA:
undetectable
2rlfD-3iwzA:
undetectable		 2rlfA-3iwzA:
12.16
2rlfD-3iwzA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbr CYCLOHEXADIENYL
DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF00497
(SBP_bac_3) 		4 ILE A  99
ARG A  29
LEU A 227
LEU A  39
 None
 0.99A 2rlfA-3kbrA:
undetectable
2rlfD-3kbrA:
undetectable		 2rlfA-3kbrA:
11.84
2rlfD-3kbrA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwn KINESIN-LIKE PROTEIN
KIF9

(Homo sapiens) 		PF00225
(Kinesin) 		4 TRP A  53
ILE A  35
LEU A 331
LEU A  37
 None
 1.05A 2rlfA-3nwnA:
undetectable
2rlfD-3nwnA:
undetectable		 2rlfA-3nwnA:
11.76
2rlfD-3nwnA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q10 PANTOATE--BETA-ALANI
NE LIGASE

(Yersinia pestis) 		PF02569
(Pantoate_ligase) 		4 ILE A 222
ARG A 246
LEU A 254
LEU A 226
 None
 0.95A 2rlfA-3q10A:
undetectable
2rlfD-3q10A:
undetectable		 2rlfA-3q10A:
8.13
2rlfD-3q10A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1n GALACTOSE MUTAROTASE
RELATED ENZYME

(Lactobacillus
paracasei) 		PF01263
(Aldose_epim) 		4 ILE A 240
ARG A 171
LEU A 209
LEU A 202
 None
 1.05A 2rlfA-3q1nA:
undetectable
2rlfD-3q1nA:
undetectable		 2rlfA-3q1nA:
8.39
2rlfD-3q1nA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh2 HYPOTHETICAL
TETR-LIKE
TRANSCRIPTIONAL
REGULATOR

(Shewanella
amazonensis) 		PF00440
(TetR_N)
PF13972
(TetR) 		4 TRP A 158
ILE A 159
LEU A 163
LEU A 176
 None
 0.83A 2rlfA-3rh2A:
undetectable
2rlfD-3rh2A:
undetectable		 2rlfA-3rh2A:
12.50
2rlfD-3rh2A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ber PHOSPHOCHOLINE
TRANSFERASE ANKX

(Legionella
pneumophila) 		PF02661
(Fic)
PF12796
(Ank_2) 		4 TRP A  23
ILE A  22
ARG A  24
LEU A  25
 None
 1.01A 2rlfA-4berA:
undetectable
2rlfD-4berA:
undetectable		 2rlfA-4berA:
6.13
2rlfD-4berA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A

(Aspergillus
tubingensis) 		PF00295
(Glyco_hydro_28) 		4 ILE A 164
ARG A 123
LEU A 167
LEU A 120
 None
 1.05A 2rlfA-4c2lA:
undetectable
2rlfD-4c2lA:
undetectable		 2rlfA-4c2lA:
7.90
2rlfD-4c2lA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci6 PROTEIN KINASE YOPO

(Yersinia
enterocolitica) 		PF00069
(Pkinase)
PF09632
(Rac1) 		4 ILE B 247
ARG B 250
LEU B 251
LEU B 419
 None
 0.71A 2rlfA-4ci6B:
undetectable
2rlfD-4ci6B:
undetectable		 2rlfA-4ci6B:
5.41
2rlfD-4ci6B:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ct3 ORF30/ORF32

(Staphylococcus
virus K) 		PF05257
(CHAP) 		4 ILE A   8
ARG A  11
LEU A  12
LEU A  65
 None
GOL  A1168 (-3.7A)
None
None
 0.96A 2rlfA-4ct3A:
undetectable
2rlfD-4ct3A:
undetectable		 2rlfA-4ct3A:
16.46
2rlfD-4ct3A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 ILE A 498
LEU A 500
LEU A 512
ASP A 509
 None
 0.86A 2rlfA-4f7zA:
undetectable
2rlfD-4f7zA:
undetectable		 2rlfA-4f7zA:
4.24
2rlfD-4f7zA:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbh PROTEIN SYNTHESIS
INHIBITOR I

(Hordeum vulgare) 		PF00161
(RIP) 		4 ILE A  86
ARG A  82
LEU A  51
ASP A  84
 None
 1.01A 2rlfA-4fbhA:
undetectable
2rlfD-4fbhA:
undetectable		 2rlfA-4fbhA:
9.61
2rlfD-4fbhA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gak ACYL-ACP
THIOESTERASE

(Spirosoma
linguale) 		PF01643
(Acyl-ACP_TE) 		4 ILE A 127
LEU A 130
LEU A  49
ASP A  48
 None
 0.95A 2rlfA-4gakA:
undetectable
2rlfD-4gakA:
undetectable		 2rlfA-4gakA:
10.25
2rlfD-4gakA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvf BETA-HEXOSAMINIDASE

(Salmonella
enterica) 		PF00933
(Glyco_hydro_3) 		4 ILE A  49
ARG A  18
LEU A  21
LEU A  45
 None
 0.95A 2rlfA-4gvfA:
undetectable
2rlfD-4gvfA:
undetectable		 2rlfA-4gvfA:
8.72
2rlfD-4gvfA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jin RIO-TYPE
SERINE/THREONINE-PRO
TEIN KINASE RIO1

(Archaeoglobus
fulgidus) 		PF01163
(RIO1) 		4 TRP A 116
ILE A 115
LEU A  96
ASP A  93
 None
 0.97A 2rlfA-4jinA:
undetectable
2rlfD-4jinA:
undetectable		 2rlfA-4jinA:
12.87
2rlfD-4jinA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m38 PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Trypanosoma
brucei) 		PF06325
(PrmA) 		4 ILE A 281
ARG A 278
LEU A 179
ASP A 185
 None
 0.90A 2rlfA-4m38A:
undetectable
2rlfD-4m38A:
undetectable		 2rlfA-4m38A:
12.31
2rlfD-4m38A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 ILE E 498
LEU E 500
LEU E 512
ASP E 509
 None
 0.81A 2rlfA-4mh0E:
undetectable
2rlfD-4mh0E:
undetectable		 2rlfA-4mh0E:
5.31
2rlfD-4mh0E:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3m BLOOM SYNDROME
PROTEIN

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF00570
(HRDC)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		4 ILE A 882
ARG A 883
LEU A 908
ASP A 911
 None
 0.97A 2rlfA-4o3mA:
undetectable
2rlfD-4o3mA:
undetectable		 2rlfA-4o3mA:
6.37
2rlfD-4o3mA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00171
(Aldedh) 		4 ILE A 356
ARG A 268
LEU A 350
ASP A 233
 None
 1.06A 2rlfA-4ohtA:
undetectable
2rlfD-4ohtA:
undetectable		 2rlfA-4ohtA:
7.93
2rlfD-4ohtA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1

(Escherichia
coli;
Homo sapiens) 		PF00003
(7tm_3)
PF07361
(Cytochrom_B562) 		4 ILE A1102
ARG A1098
LEU A1068
LEU A1106
 None
 1.02A 2rlfA-4or2A:
undetectable
2rlfD-4or2A:
undetectable		 2rlfA-4or2A:
11.28
2rlfD-4or2A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2v CYSTEINE SYNTHETASE

(Helicobacter
pylori) 		PF00291
(PALP) 		4 ILE A 199
ARG A 200
LEU A 201
ASP A 239
 None
 0.93A 2rlfA-4r2vA:
undetectable
2rlfD-4r2vA:
undetectable		 2rlfA-4r2vA:
8.64
2rlfD-4r2vA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9p RE28239P

(Drosophila
melanogaster) 		PF03166
(MH2) 		4 ILE A  81
ARG A  92
LEU A  95
LEU A  79
 None
 1.00A 2rlfA-4r9pA:
undetectable
2rlfD-4r9pA:
undetectable		 2rlfA-4r9pA:
11.16
2rlfD-4r9pA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 4 ILE A 497
ARG A 222
LEU A 473
ASP A 223
 None
 1.00A 2rlfA-4tz5A:
undetectable
2rlfD-4tz5A:
undetectable		 2rlfA-4tz5A:
6.04
2rlfD-4tz5A:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uar PROTEIN CBBY

(Rhodobacter
sphaeroides) 		PF13419
(HAD_2) 		4 ILE A 109
ARG A 110
LEU A 111
ASP A 139
 None
 0.83A 2rlfA-4uarA:
undetectable
2rlfD-4uarA:
undetectable		 2rlfA-4uarA:
12.94
2rlfD-4uarA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvj COHESIN SUBUNIT SCC3

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A 899
ARG A 902
LEU A 903
LEU A 829
 None
 0.76A 2rlfA-4uvjA:
undetectable
2rlfD-4uvjA:
undetectable		 2rlfA-4uvjA:
9.12
2rlfD-4uvjA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8h TOLL-RECEPTOR-RELATE
D 2

(Hydra vulgaris) 		PF13676
(TIR_2) 		4 ILE A 154
ARG A 152
LEU A 214
ASP A 217
 None
 1.01A 2rlfA-4w8hA:
undetectable
2rlfD-4w8hA:
undetectable		 2rlfA-4w8hA:
14.63
2rlfD-4w8hA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnr LEUCINE-RICH-REPEAT
PROTEIN

(Methanosarcina
barkeri) 		PF08477
(Roc)
PF16095
(COR) 		4 ILE A 458
ARG A 340
LEU A 337
ASP A 463
 None
 0.88A 2rlfA-4wnrA:
undetectable
2rlfD-4wnrA:
undetectable		 2rlfA-4wnrA:
13.14
2rlfD-4wnrA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ac9 VP1

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 TRP 1  88
ILE 1 168
LEU 1  86
LEU 1  51
 None
 1.05A 2rlfA-5ac91:
undetectable
2rlfD-5ac91:
undetectable		 2rlfA-5ac91:
11.27
2rlfD-5ac91:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2y RNA POLYMERASE II
SUBUNIT B1 CTD
PHOSPHATASE RTR1

(Saccharomyces
cerevisiae) 		PF04181
(RPAP2_Rtr1) 		4 ILE A   7
ARG A  53
LEU A  51
LEU A  12
 None
 1.05A 2rlfA-5c2yA:
undetectable
2rlfD-5c2yA:
undetectable		 2rlfA-5c2yA:
12.24
2rlfD-5c2yA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwm PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE

(Brucella ovis) 		PF13420
(Acetyltransf_4) 		4 ILE A 106
LEU A 165
LEU A 102
ASP A  84
 None
 1.08A 2rlfA-5dwmA:
undetectable
2rlfD-5dwmA:
undetectable		 2rlfA-5dwmA:
13.71
2rlfD-5dwmA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		PF06325
(PrmA) 		4 ILE A 281
ARG A 278
LEU A 179
ASP A 185
 None
 1.00A 2rlfA-5ekuA:
undetectable
2rlfD-5ekuA:
undetectable		 2rlfA-5ekuA:
8.90
2rlfD-5ekuA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eu0 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella
rochalimae) 		PF02661
(Fic) 		4 ILE A 162
LEU A 166
LEU A 141
ASP A 138
 None
 1.01A 2rlfA-5eu0A:
undetectable
2rlfD-5eu0A:
undetectable		 2rlfA-5eu0A:
17.07
2rlfD-5eu0A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF08996
(zf-DNA_Pol) 		4 ILE C1006
LEU C 858
LEU C 984
ASP C1004
 None
 1.00A 2rlfA-5exrC:
undetectable
2rlfD-5exrC:
undetectable		 2rlfA-5exrC:
3.55
2rlfD-5exrC:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp0 NUDIX HYDROLASE 1

(Arabidopsis
thaliana) 		no annotation 4 ILE E  22
LEU E  17
LEU E 122
ASP E 118
 None
 0.91A 2rlfA-5gp0E:
undetectable
2rlfD-5gp0E:
undetectable		 2rlfA-5gp0E:
14.19
2rlfD-5gp0E:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioo AVPA

(Nanoarchaeota
archaeon JGI
OTU-1) 		no annotation 4 ILE A  58
ARG A 182
LEU A 184
ASP A 174
 None
 1.08A 2rlfA-5iooA:
undetectable
2rlfD-5iooA:
undetectable		 2rlfA-5iooA:
10.96
2rlfD-5iooA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		4 ILE A 526
ARG A 524
LEU A 166
LEU A 465
 None
 1.03A 2rlfA-5jjhA:
undetectable
2rlfD-5jjhA:
undetectable		 2rlfA-5jjhA:
5.18
2rlfD-5jjhA:
5.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l25 BORON TRANSPORTER 1

(Arabidopsis
thaliana) 		PF00955
(HCO3_cotransp) 		4 ILE A 513
ARG A 512
LEU A 516
LEU A 161
 None
 1.04A 2rlfA-5l25A:
undetectable
2rlfD-5l25A:
undetectable		 2rlfA-5l25A:
5.08
2rlfD-5l25A:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4w CULLIN-2

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 ILE A 319
LEU A 315
LEU A 372
ASP A 369
 None
 1.07A 2rlfA-5n4wA:
undetectable
2rlfD-5n4wA:
undetectable		 2rlfA-5n4wA:
5.13
2rlfD-5n4wA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7f MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1,ANNEXIN A2

(Homo sapiens) 		no annotation 4 ILE A 671
ARG A 674
LEU A 653
ASP A 649
 None
GOL  A 903 ( 3.8A)
None
GOL  A 903 (-3.5A)
 1.07A 2rlfA-5n7fA:
undetectable
2rlfD-5n7fA:
undetectable		 2rlfA-5n7fA:
8.21
2rlfD-5n7fA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL

(Homo sapiens) 		PF07147
(PDCD9) 		4 ILE 5 314
ARG 5 310
LEU 5 355
LEU 5 121
 None
 1.00A 2rlfA-5ool5:
undetectable
2rlfD-5ool5:
undetectable		 2rlfA-5ool5:
7.22
2rlfD-5ool5:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thz CURJ

(Moorea
producens) 		no annotation 4 ILE B 204
LEU B 279
LEU B 254
ASP B 255
 None
None
None
SAH  B 501 (-3.9A)
 0.96A 2rlfA-5thzB:
undetectable
2rlfD-5thzB:
undetectable		 2rlfA-5thzB:
9.14
2rlfD-5thzB:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti1 FUMARYLACETOACETATE
HYDROLASE

(Paraburkholderia
xenovorans) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		5 ILE A 333
ARG A 400
LEU A 392
LEU A 409
ASP A 407
 None
 1.29A 2rlfA-5ti1A:
undetectable
2rlfD-5ti1A:
undetectable		 2rlfA-5ti1A:
7.21
2rlfD-5ti1A:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Pseudomonas
syringae) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 ILE A  17
ARG A  20
LEU A  21
LEU A 135
 None
 1.05A 2rlfA-5u5gA:
undetectable
2rlfD-5u5gA:
undetectable		 2rlfA-5u5gA:
9.69
2rlfD-5u5gA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucv PROBABLE GTP-BINDING
PROTEIN ENGB

(Neisseria
gonorrhoeae) 		PF01926
(MMR_HSR1) 		4 ILE A 139
LEU A 141
LEU A 127
ASP A 123
 None
 1.08A 2rlfA-5ucvA:
undetectable
2rlfD-5ucvA:
undetectable		 2rlfA-5ucvA:
17.11
2rlfD-5ucvA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		4 ILE A 118
ARG A 121
LEU A 122
LEU A 250
 None
 1.06A 2rlfA-5ujuA:
undetectable
2rlfD-5ujuA:
undetectable		 2rlfA-5ujuA:
5.05
2rlfD-5ujuA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 4 ILE A 276
LEU A 261
LEU A 295
ASP A 292
 None
 1.06A 2rlfA-5veuA:
undetectable
2rlfD-5veuA:
undetectable		 2rlfA-5veuA:
9.07
2rlfD-5veuA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 TRP A 469
ILE A 486
ARG A 485
LEU A 464
 None
 0.96A 2rlfA-5wu7A:
undetectable
2rlfD-5wu7A:
undetectable		 2rlfA-5wu7A:
6.16
2rlfD-5wu7A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xei CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
yayanosii) 		PF02463
(SMC_N) 		4 ILE A 163
ARG A 159
LEU A 162
LEU A1039
 None
 1.07A 2rlfA-5xeiA:
undetectable
2rlfD-5xeiA:
undetectable		 2rlfA-5xeiA:
8.52
2rlfD-5xeiA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT

(Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ILE A1355
ARG A1102
LEU A1103
LEU A1351
 None
 1.08A 2rlfA-5xogA:
undetectable
2rlfD-5xogA:
undetectable		 2rlfA-5xogA:
2.26
2rlfD-5xogA:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog RNA POLYMERASE II
SUBUNIT B32

(Komagataella
phaffii) 		PF03874
(RNA_pol_Rpb4) 		4 ILE D  60
ARG D  61
LEU D 109
LEU D  64
 None
 1.05A 2rlfA-5xogD:
undetectable
2rlfD-5xogD:
undetectable		 2rlfA-5xogD:
15.50
2rlfD-5xogD:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE

(Hydra vulgaris) 		no annotation 4 ILE A 315
ARG A 171
LEU A  84
ASP A 284
 None
 1.00A 2rlfA-5xomA:
undetectable
2rlfD-5xomA:
undetectable		 2rlfA-5xomA:
25.35
2rlfD-5xomA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpv AMPHIOXUS IGVJ-C2

(Branchiostoma
floridae) 		no annotation 4 ILE A  64
ARG A  68
LEU A  67
LEU A  48
 None
 0.89A 2rlfA-5xpvA:
undetectable
2rlfD-5xpvA:
undetectable		 2rlfA-5xpvA:
16.00
2rlfD-5xpvA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpw AMPHIOXUS IGVJ-C2

(Branchiostoma
floridae) 		no annotation 4 ILE A  64
ARG A  68
LEU A  67
LEU A  48
 None
 0.85A 2rlfA-5xpwA:
undetectable
2rlfD-5xpwA:
undetectable		 2rlfA-5xpwA:
16.00
2rlfD-5xpwA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE

(Escherichia
coli) 		no annotation 4 ILE A 228
ARG A 255
LEU A 258
LEU A 230
 None
 0.95A 2rlfA-5z03A:
undetectable
2rlfD-5z03A:
undetectable		 2rlfA-5z03A:
20.00
2rlfD-5z03A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF

(Caldanaerobacter
subterraneus) 		no annotation 4 ILE A 223
LEU A 272
LEU A 225
ASP A 268
 None
 1.06A 2rlfA-5z67A:
undetectable
2rlfD-5z67A:
undetectable		 2rlfA-5z67A:
19.74
2rlfD-5z67A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 ILE A 864
ARG A 863
LEU A 758
LEU A 995
 None
 1.06A 2rlfA-6etzA:
undetectable
2rlfD-6etzA:
undetectable		 2rlfA-6etzA:
19.44
2rlfD-6etzA:
19.44