SIMILAR PATTERNS OF AMINO ACIDS FOR 2RLF_C_RIMC399_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bo9 PROTEIN (ANNEXIN I)

(Homo sapiens) 		PF00191
(Annexin) 		4 LEU A  52
LEU A  56
ILE A  40
ARG A  37
 None
 0.97A 2rlfC-1bo9A:
0.0
2rlfD-1bo9A:
0.0		 2rlfC-1bo9A:
26.03
2rlfD-1bo9A:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		4 LEU A  29
LEU A  25
ILE A  32
ARG A  31
 None
PC1  A 777 ( 4.1A)
None
None
 0.99A 2rlfC-1bp1A:
0.0
2rlfD-1bp1A:
0.0		 2rlfC-1bp1A:
6.24
2rlfD-1bp1A:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 LEU A 906
ASP A 904
ILE A1023
ARG A1027
 None
 1.00A 2rlfC-1c30A:
0.0
2rlfD-1c30A:
0.0		 2rlfC-1c30A:
3.88
2rlfD-1c30A:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)

(Physarum
polycephalum) 		PF09192
(Act-Frag_cataly) 		4 LEU A 193
LEU A 196
ASP A 197
ILE A 219
 None
 0.95A 2rlfC-1cjaA:
0.0
2rlfD-1cjaA:
0.0		 2rlfC-1cjaA:
9.69
2rlfD-1cjaA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eay CHEA

(Escherichia
coli) 		PF09078
(CheY-binding) 		4 LEU C 164
LEU C 195
ILE C 162
ARG C 161
 None
 0.99A 2rlfC-1eayC:
0.0
2rlfD-1eayC:
0.0		 2rlfC-1eayC:
21.62
2rlfD-1eayC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 LEU S 781
LEU S 784
ILE S 725
ARG S 733
 None
 0.89A 2rlfC-1i84S:
2.5
2rlfD-1i84S:
0.9		 2rlfC-1i84S:
3.99
2rlfD-1i84S:
3.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjf ENDO-1,4-BETA-XYLANA
SE Z

(Ruminiclostridium
thermocellum) 		PF00756
(Esterase) 		4 LEU A 145
LEU A 149
ILE A 168
ARG A 166
 None
 0.95A 2rlfC-1jjfA:
undetectable
2rlfD-1jjfA:
0.0		 2rlfC-1jjfA:
10.27
2rlfD-1jjfA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli) 		PF01784
(NIF3) 		4 LEU A 112
LEU A 115
TRP A 170
ILE A 191
 None
 0.97A 2rlfC-1nmoA:
0.0
2rlfD-1nmoA:
0.0		 2rlfC-1nmoA:
13.88
2rlfD-1nmoA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnt OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		4 LEU A 267
LEU A 307
ILE A 263
ARG A 309
 None
 0.97A 2rlfC-1nntA:
0.0
2rlfD-1nntA:
undetectable		 2rlfC-1nntA:
8.12
2rlfD-1nntA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4s ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		4 LEU A 367
LEU A 363
ILE A 370
ARG A 369
 None
 0.98A 2rlfC-1o4sA:
undetectable
2rlfD-1o4sA:
undetectable		 2rlfC-1o4sA:
8.06
2rlfD-1o4sA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		4 LEU A  27
LEU A  56
ILE A  51
ARG A  52
 None
None
None
XYP  A 601 ( 4.9A)
 0.92A 2rlfC-1px8A:
undetectable
2rlfD-1px8A:
undetectable		 2rlfC-1px8A:
7.14
2rlfD-1px8A:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1

(Bos taurus) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		4 LEU A 206
LEU A 211
ILE A 215
ARG A 170
 None
 0.99A 2rlfC-1pztA:
undetectable
2rlfD-1pztA:
undetectable		 2rlfC-1pztA:
9.75
2rlfD-1pztA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrh ECO RI ENDONCULEASE

(Escherichia
coli) 		PF02963
(EcoRI) 		4 LEU A 204
LEU A 201
ILE A 143
ARG A 200
 None
 0.94A 2rlfC-1qrhA:
undetectable
2rlfD-1qrhA:
undetectable		 2rlfC-1qrhA:
11.88
2rlfD-1qrhA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5m SIR4-INTERACTING
PROTEIN SIF2

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 LEU A 374
LEU A 375
ILE A 341
ARG A 384
 None
 1.00A 2rlfC-1r5mA:
undetectable
2rlfD-1r5mA:
undetectable		 2rlfC-1r5mA:
7.84
2rlfD-1r5mA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rii 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Mycobacterium
tuberculosis) 		PF00300
(His_Phos_1) 		4 LEU A 179
LEU A  56
ILE A  46
ARG A  77
 None
 0.80A 2rlfC-1riiA:
undetectable
2rlfD-1riiA:
undetectable		 2rlfC-1riiA:
11.11
2rlfD-1riiA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tu3 RAB GTPASE BINDING
EFFECTOR PROTEIN 1

(Homo sapiens) 		PF09311
(Rab5-bind) 		4 LEU F 832
LEU F 828
ILE F 835
ARG F 834
 None
 1.01A 2rlfC-1tu3F:
2.0
2rlfD-1tu3F:
2.5		 2rlfC-1tu3F:
13.92
2rlfD-1tu3F:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vav ALGINATE LYASE
PA1167

(Pseudomonas
aeruginosa) 		PF08787
(Alginate_lyase2) 		4 LEU A   9
LEU A  62
ILE A  11
ARG A  59
 None
 0.92A 2rlfC-1vavA:
undetectable
2rlfD-1vavA:
undetectable		 2rlfC-1vavA:
13.16
2rlfD-1vavA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8a SLIT PROTEIN

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 LEU A 607
LEU A 582
ILE A 610
ARG A 584
 None
 0.95A 2rlfC-1w8aA:
undetectable
2rlfD-1w8aA:
undetectable		 2rlfC-1w8aA:
15.66
2rlfD-1w8aA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 LEU B 112
LEU B 327
TRP B 331
ILE B 334
 None
 1.00A 2rlfC-1wytB:
undetectable
2rlfD-1wytB:
undetectable		 2rlfC-1wytB:
7.19
2rlfD-1wytB:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0h TALIN-1

(Mus musculus) 		PF08913
(VBS) 		4 LEU A1968
LEU A1965
ILE A1916
ARG A1919
 None
 0.78A 2rlfC-2b0hA:
undetectable
2rlfD-2b0hA:
undetectable		 2rlfC-2b0hA:
20.37
2rlfD-2b0hA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		4 LEU A  27
LEU A  56
ILE A  51
ARG A  52
 None
 0.93A 2rlfC-2bs9A:
undetectable
2rlfD-2bs9A:
undetectable		 2rlfC-2bs9A:
7.32
2rlfD-2bs9A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2edw OBSCURIN

(Homo sapiens) 		PF07679
(I-set) 		4 LEU A  64
LEU A  55
ILE A  66
ARG A  67
 None
 0.76A 2rlfC-2edwA:
undetectable
2rlfD-2edwA:
undetectable		 2rlfC-2edwA:
17.14
2rlfD-2edwA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f22 BH3987

(Bacillus
halodurans) 		PF05163
(DinB) 		4 LEU A  36
LEU A  39
TRP A  25
ILE A  20
 None
 0.55A 2rlfC-2f22A:
undetectable
2rlfD-2f22A:
undetectable		 2rlfC-2f22A:
26.51
2rlfD-2f22A:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL

(Escherichia
coli) 		PF03466
(LysR_substrate) 		4 LEU A 259
LEU A 170
ILE A 257
ARG A 258
 None
 0.90A 2rlfC-2fyiA:
undetectable
2rlfD-2fyiA:
undetectable		 2rlfC-2fyiA:
14.16
2rlfD-2fyiA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 LEU A 426
LEU A 449
ILE A 428
ARG A 125
 None
None
None
SO4  A 505 ( 3.0A)
 0.98A 2rlfC-2hgsA:
undetectable
2rlfD-2hgsA:
undetectable		 2rlfC-2hgsA:
8.41
2rlfD-2hgsA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Staphylococcus
aureus) 		PF00005
(ABC_tran) 		4 LEU A 185
LEU A 182
ILE A 153
ARG A 150
 None
 0.68A 2rlfC-2ihyA:
undetectable
2rlfD-2ihyA:
undetectable		 2rlfC-2ihyA:
10.39
2rlfD-2ihyA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 LEU A 695
LEU A 723
ILE A 691
ARG A 205
 None
 0.87A 2rlfC-2ivfA:
undetectable
2rlfD-2ivfA:
undetectable		 2rlfC-2ivfA:
3.83
2rlfD-2ivfA:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kdd BOREALIN

(Homo sapiens) 		PF10512
(Borealin) 		4 LEU A 269
LEU A 265
ILE A 272
ARG A 268
 None
 0.91A 2rlfC-2kddA:
undetectable
2rlfD-2kddA:
undetectable		 2rlfC-2kddA:
19.48
2rlfD-2kddA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kvp TALIN-1

(Mus musculus) 		PF08913
(VBS) 		4 LEU A1968
LEU A1965
ILE A1916
ARG A1919
 None
 0.87A 2rlfC-2kvpA:
undetectable
2rlfD-2kvpA:
undetectable		 2rlfC-2kvpA:
20.37
2rlfD-2kvpA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lp4 CHEMOTAXIS PROTEIN
CHEA

(Escherichia
coli) 		PF01627
(Hpt)
PF09078
(CheY-binding) 		4 LEU A 164
LEU A 195
ILE A 162
ARG A 161
 None
 0.99A 2rlfC-2lp4A:
undetectable
2rlfD-2lp4A:
undetectable		 2rlfC-2lp4A:
16.67
2rlfD-2lp4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oce HYPOTHETICAL PROTEIN
PA5201

(Pseudomonas
aeruginosa) 		PF00575
(S1)
PF09371
(Tex_N)
PF12836
(HHH_3)
PF16921
(Tex_YqgF) 		4 LEU A 184
LEU A 181
ILE A 260
ARG A 263
 None
 0.94A 2rlfC-2oceA:
undetectable
2rlfD-2oceA:
undetectable		 2rlfC-2oceA:
3.97
2rlfD-2oceA:
3.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv3 VACUOLATING
CYTOTOXIN

(Helicobacter
pylori) 		PF02691
(VacA) 		4 LEU A 629
LEU A 608
ILE A 631
ARG A 583
 None
 0.97A 2rlfC-2qv3A:
undetectable
2rlfD-2qv3A:
undetectable		 2rlfC-2qv3A:
9.50
2rlfD-2qv3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raq CONSERVED PROTEIN
MTH889

(Methanothermobacter
thermautotrophicus) 		PF02680
(DUF211) 		4 LEU A  60
LEU A   6
ILE A  55
ARG A   8
 None
 0.98A 2rlfC-2raqA:
undetectable
2rlfD-2raqA:
undetectable		 2rlfC-2raqA:
16.09
2rlfD-2raqA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5i SALMONELLA
TYPHIMURIUM DB7155
BACTERIOPHAGE DET7
TAILSPIKE

(unidentified
phage) 		PF09251
(PhageP22-tail) 		4 LEU A 307
LEU A 224
ILE A 309
ARG A 310
 None
 0.79A 2rlfC-2v5iA:
undetectable
2rlfD-2v5iA:
undetectable		 2rlfC-2v5iA:
6.77
2rlfD-2v5iA:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbi PYRUVATE
DECARBOXYLASE

(Acetobacter
pasteurianus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A  13
LEU A   9
ILE A  16
ARG A  12
 None
 0.91A 2rlfC-2vbiA:
undetectable
2rlfD-2vbiA:
undetectable		 2rlfC-2vbiA:
7.24
2rlfD-2vbiA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A  13
LEU A   9
ILE A  16
ARG A  12
 None
 1.00A 2rlfC-2wvgA:
undetectable
2rlfD-2wvgA:
undetectable		 2rlfC-2wvgA:
5.87
2rlfD-2wvgA:
5.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 LEU A 111
LEU A 113
ILE A 107
ARG A 108
 None
 0.97A 2rlfC-2x0qA:
undetectable
2rlfD-2x0qA:
undetectable		 2rlfC-2x0qA:
4.61
2rlfD-2x0qA:
4.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xac VASCULAR ENDOTHELIAL
GROWTH FACTOR B

(Homo sapiens) 		PF00341
(PDGF) 		4 LEU A  81
LEU A  90
ILE A  83
ARG A  84
 None
 0.99A 2rlfC-2xacA:
undetectable
2rlfD-2xacA:
undetectable		 2rlfC-2xacA:
13.40
2rlfD-2xacA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhg TYROCIDINE
SYNTHETASE A

(Brevibacillus
brevis) 		PF00668
(Condensation) 		4 LEU A 140
LEU A  43
ILE A  54
ARG A  45
 None
 0.95A 2rlfC-2xhgA:
undetectable
2rlfD-2xhgA:
undetectable		 2rlfC-2xhgA:
9.62
2rlfD-2xhgA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbk TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A

(Sulfolobus
shibatae) 		PF04406
(TP6A_N) 		4 LEU A 178
LEU A 167
ILE A 176
ARG A 168
 None
 0.85A 2rlfC-2zbkA:
undetectable
2rlfD-2zbkA:
undetectable		 2rlfC-2zbkA:
8.36
2rlfD-2zbkA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvy CHEMOTAXIS PROTEIN
MOTB

(Salmonella
enterica) 		PF00691
(OmpA) 		4 LEU A 149
LEU A 144
ILE A 151
ARG A 150
 None
 0.93A 2rlfC-2zvyA:
undetectable
2rlfD-2zvyA:
undetectable		 2rlfC-2zvyA:
13.77
2rlfD-2zvyA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 241
LEU A 308
ILE A 239
ARG A 307
 None
 1.01A 2rlfC-3gyrA:
undetectable
2rlfD-3gyrA:
undetectable		 2rlfC-3gyrA:
6.05
2rlfD-3gyrA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		4 LEU A 183
LEU A 184
ASP A 175
ILE A 273
 None
None
SAH  A 401 ( 4.2A)
None
 0.95A 2rlfC-3i58A:
undetectable
2rlfD-3i58A:
undetectable		 2rlfC-3i58A:
9.52
2rlfD-3i58A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq2 SORTING NEXIN-7

(Homo sapiens) 		PF00787
(PX) 		4 LEU A 125
LEU A 121
ILE A 128
ARG A 127
 None
 0.87A 2rlfC-3iq2A:
undetectable
2rlfD-3iq2A:
undetectable		 2rlfC-3iq2A:
20.18
2rlfD-3iq2A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isp HTH-TYPE
TRANSCRIPTIONAL
REGULATOR
RV1985C/MT2039

(Mycobacterium
tuberculosis) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 LEU A  14
LEU A  11
ILE A  41
ARG A  40
 None
 0.96A 2rlfC-3ispA:
undetectable
2rlfD-3ispA:
undetectable		 2rlfC-3ispA:
8.53
2rlfD-3ispA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1

(Ehrlichia
chaffeensis) 		PF13419
(HAD_2) 		4 LEU A  94
LEU A  91
ILE A 204
ARG A 201
 None
 0.86A 2rlfC-3kzxA:
undetectable
2rlfD-3kzxA:
undetectable		 2rlfC-3kzxA:
23.96
2rlfD-3kzxA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 LEU A 966
LEU A 903
ILE A 890
ARG A 889
 None
 0.89A 2rlfC-3l4kA:
undetectable
2rlfD-3l4kA:
undetectable		 2rlfC-3l4kA:
4.40
2rlfD-3l4kA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqb LOC792177 PROTEIN

(Danio rerio) 		PF01400
(Astacin) 		4 LEU A 185
LEU A 152
ILE A 193
ARG A 192
 None
 0.77A 2rlfC-3lqbA:
undetectable
2rlfD-3lqbA:
undetectable		 2rlfC-3lqbA:
9.55
2rlfD-3lqbA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mb2 4-OXALOCROTONATE
TAUTOMERASE FAMILY
ENZYME - ALPHA
SUBUNIT

(Chloroflexus
aurantiacus) 		PF01361
(Tautomerase) 		4 LEU A  41
LEU A   4
ILE A  43
ARG A   5
 None
 0.95A 2rlfC-3mb2A:
undetectable
2rlfD-3mb2A:
undetectable		 2rlfC-3mb2A:
18.18
2rlfD-3mb2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 LEU B 734
LEU B 737
ILE B 494
ARG B 493
 None
 0.92A 2rlfC-3o8oB:
undetectable
2rlfD-3o8oB:
undetectable		 2rlfC-3o8oB:
5.11
2rlfD-3o8oB:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkm CAS6 PROTEIN

(Pyrococcus
furiosus) 		PF01881
(Cas_Cas6) 		4 LEU A 119
LEU A  13
ILE A 122
ARG A  12
 None
None
None
U  G   2 ( 3.5A)
 0.96A 2rlfC-3pkmA:
undetectable
2rlfD-3pkmA:
undetectable		 2rlfC-3pkmA:
9.77
2rlfD-3pkmA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9w GTPASE ERA

(Aquifex
aeolicus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		4 LEU A 190
LEU A 193
ILE A 221
ARG A 191
 None
 0.98A 2rlfC-3r9wA:
undetectable
2rlfD-3r9wA:
undetectable		 2rlfC-3r9wA:
9.38
2rlfD-3r9wA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		4 LEU A 287
LEU A 258
ILE A 263
ARG A 262
 None
 0.96A 2rlfC-3swgA:
undetectable
2rlfD-3swgA:
undetectable		 2rlfC-3swgA:
7.26
2rlfD-3swgA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE

(Coxiella
burnetii) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A  22
LEU A  19
ILE A 236
ARG A 239
 None
 0.99A 2rlfC-3uwcA:
undetectable
2rlfD-3uwcA:
undetectable		 2rlfC-3uwcA:
12.92
2rlfD-3uwcA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v67 SENSOR PROTEIN CPXA

(Vibrio
parahaemolyticus) 		PF16527
(CpxA_peri) 		4 LEU A 147
LEU A 152
ILE A  62
ARG A  59
 None
 0.96A 2rlfC-3v67A:
undetectable
2rlfD-3v67A:
undetectable		 2rlfC-3v67A:
11.97
2rlfD-3v67A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vly NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 LEU A 398
LEU A 112
ILE A 404
ARG A 397
 None
 0.94A 2rlfC-3vlyA:
undetectable
2rlfD-3vlyA:
undetectable		 2rlfC-3vlyA:
5.53
2rlfD-3vlyA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 LEU A 280
LEU A 282
ILE A 305
ARG A 287
 None
 0.99A 2rlfC-3vueA:
undetectable
2rlfD-3vueA:
undetectable		 2rlfC-3vueA:
6.78
2rlfD-3vueA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv1 PROTEIN LEC-6

(Caenorhabditis
elegans) 		PF00337
(Gal-bind_lectin) 		4 LEU A  51
LEU A  59
ILE A 131
ARG A  52
 None
 1.00A 2rlfC-3vv1A:
undetectable
2rlfD-3vv1A:
undetectable		 2rlfC-3vv1A:
16.55
2rlfD-3vv1A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A 121
LEU A  72
ASP A  73
ARG A 120
 None
 0.95A 2rlfC-4bc5A:
undetectable
2rlfD-4bc5A:
undetectable		 2rlfC-4bc5A:
6.54
2rlfD-4bc5A:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be3 ALGINATE LYASE,
FAMILY PL7

(Zobellia
galactanivorans) 		PF08787
(Alginate_lyase2) 		4 LEU A 106
LEU A 296
ILE A  54
ARG A 103
 None
None
None
SRT  A 400 (-3.6A)
 0.99A 2rlfC-4be3A:
undetectable
2rlfD-4be3A:
undetectable		 2rlfC-4be3A:
8.17
2rlfD-4be3A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A  13
LEU A   9
ILE A  16
ARG A  12
 None
 0.95A 2rlfC-4cokA:
undetectable
2rlfD-4cokA:
undetectable		 2rlfC-4cokA:
6.11
2rlfD-4cokA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0q HYALURONATE LYASE

(Streptococcus
pneumoniae) 		PF02018
(CBM_4_9) 		4 LEU A 188
LEU A 115
ILE A 202
ARG A 117
 None
 0.97A 2rlfC-4d0qA:
undetectable
2rlfD-4d0qA:
undetectable		 2rlfC-4d0qA:
16.17
2rlfD-4d0qA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU A 825
LEU A 829
ILE A 870
ARG A 867
 None
 0.96A 2rlfC-4f4cA:
undetectable
2rlfD-4f4cA:
undetectable		 2rlfC-4f4cA:
3.11
2rlfD-4f4cA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzi PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
cruzi) 		PF00248
(Aldo_ket_red) 		4 LEU A 147
LEU A 150
ILE A 183
ARG A 157
 None
 0.87A 2rlfC-4fziA:
undetectable
2rlfD-4fziA:
undetectable		 2rlfC-4fziA:
14.44
2rlfD-4fziA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu1 MAF-LIKE PROTEIN
YCEF

(Escherichia
coli) 		PF02545
(Maf) 		4 LEU A 180
LEU A 177
ILE A  66
ARG A  13
 None
 0.97A 2rlfC-4lu1A:
undetectable
2rlfD-4lu1A:
undetectable		 2rlfC-4lu1A:
18.18
2rlfD-4lu1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7o IRON-BINDING PROTEIN

(Staphylococcus
epidermidis) 		PF01497
(Peripla_BP_2) 		4 LEU A 285
LEU A 288
ILE A 168
ARG A 289
 None
 0.92A 2rlfC-4m7oA:
undetectable
2rlfD-4m7oA:
undetectable		 2rlfC-4m7oA:
11.11
2rlfD-4m7oA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PROTEIN M TD

(Mycoplasma
genitalium) 		no annotation 4 LEU M 266
LEU M 244
ILE M 268
ARG M 269
 None
None
None
GOL  M 501 (-3.9A)
 0.93A 2rlfC-4nzrM:
undetectable
2rlfD-4nzrM:
undetectable		 2rlfC-4nzrM:
7.27
2rlfD-4nzrM:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR

(Escherichia
coli) 		PF00392
(GntR)
PF07729
(FCD) 		4 LEU A 112
LEU A 109
ILE A 142
ARG A 145
 None
 0.98A 2rlfC-4p9fA:
undetectable
2rlfD-4p9fA:
undetectable		 2rlfC-4p9fA:
14.44
2rlfD-4p9fA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU A  85
LEU A 108
ILE A  88
ARG A  87
 None
 0.97A 2rlfC-4r0iA:
undetectable
2rlfD-4r0iA:
undetectable		 2rlfC-4r0iA:
9.75
2rlfD-4r0iA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rz9 PRE-MRNA-SPLICING
FACTOR 38A

(Homo sapiens) 		PF03371
(PRP38) 		4 LEU A 123
ASP A 126
ILE A 130
ARG A 128
 None
 0.92A 2rlfC-4rz9A:
undetectable
2rlfD-4rz9A:
undetectable		 2rlfC-4rz9A:
11.18
2rlfD-4rz9A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9v N-ALPHA-ACETYLTRANSF
ERASE 40

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		4 LEU B 173
LEU B 214
ILE B 156
ARG B 216
 ACO  B 301 ( 4.2A)
None
None
None
 0.90A 2rlfC-4u9vB:
undetectable
2rlfD-4u9vB:
undetectable		 2rlfC-4u9vB:
10.71
2rlfD-4u9vB:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 LEU A 526
LEU A 525
ILE A 530
ARG A 531
 None
 0.93A 2rlfC-4uwaA:
undetectable
2rlfD-4uwaA:
undetectable		 2rlfC-4uwaA:
2.65
2rlfD-4uwaA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4we6 HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU A  68
LEU A  71
ILE A  27
ARG A  69
 None
 1.00A 2rlfC-4we6A:
undetectable
2rlfD-4we6A:
undetectable		 2rlfC-4we6A:
10.37
2rlfD-4we6A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x54 OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella ovis) 		PF13561
(adh_short_C2) 		4 LEU A 103
LEU A 154
ILE A  92
ARG A  93
 None
 0.76A 2rlfC-4x54A:
undetectable
2rlfD-4x54A:
undetectable		 2rlfC-4x54A:
11.64
2rlfD-4x54A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8k RNA
POLYMERASE-BINDING
PROTEIN RBPA

(Mycobacterium
tuberculosis) 		PF13397
(RbpA) 		4 LEU B 102
LEU B  98
ILE B 105
ARG B 101
 None
None
None
EDO  A 403 (-3.5A)
 0.97A 2rlfC-4x8kB:
undetectable
2rlfD-4x8kB:
undetectable		 2rlfC-4x8kB:
21.92
2rlfD-4x8kB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xtk CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Thermotoga
maritima) 		PF01867
(Cas_Cas1) 		4 LEU A  54
LEU A  51
ILE A  19
ARG A  14
 None
 0.92A 2rlfC-4xtkA:
undetectable
2rlfD-4xtkA:
undetectable		 2rlfC-4xtkA:
10.19
2rlfD-4xtkA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Homo sapiens) 		PF04389
(Peptidase_M28) 		4 LEU A  73
LEU A  70
ILE A  91
ARG A  94
 None
 0.98A 2rlfC-4yu9A:
undetectable
2rlfD-4yu9A:
undetectable		 2rlfC-4yu9A:
9.88
2rlfD-4yu9A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 LEU B 101
LEU B  98
ASP B 419
ILE B 293
 None
 0.85A 2rlfC-4zktB:
undetectable
2rlfD-4zktB:
undetectable		 2rlfC-4zktB:
3.97
2rlfD-4zktB:
3.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a99 POLYHEDRIN

(Operophtera
brumata
cypovirus 19) 		no annotation 4 LEU A 212
LEU A 209
ILE A  56
ARG A  55
 None
 0.97A 2rlfC-5a99A:
undetectable
2rlfD-5a99A:
undetectable		 2rlfC-5a99A:
10.50
2rlfD-5a99A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		4 LEU C 269
LEU C 268
ASP C 390
ILE C 396
 None
 0.94A 2rlfC-5aa5C:
undetectable
2rlfD-5aa5C:
undetectable		 2rlfC-5aa5C:
6.54
2rlfD-5aa5C:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw0 COAT PROTEIN

(Panicum
papanivirus 1) 		no annotation 4 LEU A 123
LEU A  76
ILE A 125
ARG A  75
 None
 0.95A 2rlfC-5cw0A:
undetectable
2rlfD-5cw0A:
undetectable		 2rlfC-5cw0A:
19.20
2rlfD-5cw0A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P

(Lachancea
thermotolerans) 		no annotation 4 LEU A 425
LEU A 429
TRP A 426
ILE A 460
 None
 0.87A 2rlfC-5f0oA:
undetectable
2rlfD-5f0oA:
undetectable		 2rlfC-5f0oA:
4.19
2rlfD-5f0oA:
4.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P

(Lachancea
thermotolerans) 		no annotation 4 LEU A 634
LEU A 638
ILE A 668
ARG A 665
 None
 0.95A 2rlfC-5f0oA:
undetectable
2rlfD-5f0oA:
undetectable		 2rlfC-5f0oA:
4.19
2rlfD-5f0oA:
4.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggy IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		4 LEU A 131
LEU A 127
ILE A 134
ARG A 133
 None
 0.94A 2rlfC-5ggyA:
undetectable
2rlfD-5ggyA:
undetectable		 2rlfC-5ggyA:
13.50
2rlfD-5ggyA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		4 LEU A 622
LEU A 621
ILE A 701
ARG A 702
 None
 1.01A 2rlfC-5gl7A:
undetectable
2rlfD-5gl7A:
undetectable		 2rlfC-5gl7A:
5.12
2rlfD-5gl7A:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 4 LEU A 409
LEU A 406
ASP A 405
ILE A 459
 None
 1.01A 2rlfC-5h7jA:
undetectable
2rlfD-5h7jA:
undetectable		 2rlfC-5h7jA:
17.57
2rlfD-5h7jA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 30S RIBOSOMAL
PROTEIN S9

(Pyrococcus
abyssi) 		PF00380
(Ribosomal_S9) 		4 LEU K  49
LEU K  46
ILE K  82
ARG K  79
 None
 0.97A 2rlfC-5jb3K:
undetectable
2rlfD-5jb3K:
undetectable		 2rlfC-5jb3K:
18.45
2rlfD-5jb3K:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 LEU A 276
LEU A 284
ILE A 211
ARG A 188
 None
 0.96A 2rlfC-5n6uA:
undetectable
2rlfD-5n6uA:
undetectable		 2rlfC-5n6uA:
5.29
2rlfD-5n6uA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4

(Homo sapiens) 		no annotation 4 LEU A 474
LEU A 458
ILE A 453
ARG A 449
 None
 0.99A 2rlfC-5nqaA:
undetectable
2rlfD-5nqaA:
undetectable		 2rlfC-5nqaA:
22.08
2rlfD-5nqaA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		PF04095
(NAPRTase) 		4 LEU A 325
LEU A 328
ILE A 378
ARG A 349
 None
 0.97A 2rlfC-5u2nA:
undetectable
2rlfD-5u2nA:
undetectable		 2rlfC-5u2nA:
7.25
2rlfD-5u2nA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u77 OXYSTEROL-BINDING
PROTEIN-RELATED
PROTEIN 8

(Homo sapiens) 		no annotation 4 LEU A 103
LEU A  98
ILE A 105
ARG A  18
 None
NDB  A 201 (-4.3A)
None
None
 0.94A 2rlfC-5u77A:
undetectable
2rlfD-5u77A:
undetectable		 2rlfC-5u77A:
16.26
2rlfD-5u77A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8c TRANSCRIPTIONAL
REGULATOR

(Actinomyces
oris) 		no annotation 4 LEU A 355
LEU A 354
ILE A 184
ARG A 136
 None
 0.86A 2rlfC-5v8cA:
undetectable
2rlfD-5v8cA:
undetectable		 2rlfC-5v8cA:
15.19
2rlfD-5v8cA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA

(Escherichia
virus T4;
Mycobacterium
kansasii) 		PF00959
(Phage_lysozyme)
PF14011
(ESX-1_EspG) 		4 LEU A 263
LEU A 260
ILE A 236
ARG A 235
 CL  A1205 ( 4.4A)
None
None
None
 0.94A 2rlfC-5vbaA:
undetectable
2rlfD-5vbaA:
undetectable		 2rlfC-5vbaA:
6.33
2rlfD-5vbaA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x41 COBALT ABC
TRANSPORTER
ATP-BINDING PROTEIN

(Rhodobacter
capsulatus) 		PF00005
(ABC_tran) 		4 LEU A 183
LEU A 180
ILE A 151
ARG A 148
 None
 0.88A 2rlfC-5x41A:
undetectable
2rlfD-5x41A:
undetectable		 2rlfC-5x41A:
10.19
2rlfD-5x41A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		4 LEU A 168
LEU A 171
ASP A 172
ILE A 161
 None
 0.92A 2rlfC-5xfaA:
undetectable
2rlfD-5xfaA:
undetectable		 2rlfC-5xfaA:
6.26
2rlfD-5xfaA:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY

(Thermobifida
fusca) 		no annotation 4 LEU M 200
ASP M 202
ILE M 219
ARG M  32
 None
 0.93A 2rlfC-6c66M:
undetectable
2rlfD-6c66M:
undetectable		 2rlfC-6c66M:
19.28
2rlfD-6c66M:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwx RIBONUCLEASE P
PROTEIN SUBUNIT P25

(Homo sapiens) 		no annotation 4 LEU B 135
LEU B  97
ILE B 137
ARG B  96
 None
None
None
SO4  B 203 (-4.0A)
 1.00A 2rlfC-6cwxB:
undetectable
2rlfD-6cwxB:
undetectable		 2rlfC-6cwxB:
16.67
2rlfD-6cwxB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo sapiens) 		no annotation 4 LEU A 228
LEU A 225
ILE A 196
ARG A 193
 None
 0.77A 2rlfC-6etiA:
undetectable
2rlfD-6etiA:
undetectable		 2rlfC-6etiA:
20.51
2rlfD-6etiA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1t CYTOPLASMIC DYNEIN 1
HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,DYNEIN HEAVY
CHAIN,CYTOPLASMIC
DYNEIN 1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,DYNEIN HEAVY
CHAIN,CYTOPLASMIC
DYNEIN 1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN 1

(Homo sapiens) 		no annotation 4 LEU e 285
LEU e 281
ILE e 288
ARG e 287
 None
 0.96A 2rlfC-6f1te:
undetectable
2rlfD-6f1te:
undetectable		 2rlfC-6f1te:
24.05
2rlfD-6f1te:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1o -

(-) 		no annotation 4 LEU A 145
LEU A 148
ILE A  35
ARG A  32
 None
 0.92A 2rlfC-6g1oA:
undetectable
2rlfD-6g1oA:
undetectable		 2rlfC-6g1oA:
undetectable
2rlfD-6g1oA:
undetectable