SIMILAR PATTERNS OF AMINO ACIDS FOR 2RLF_B_RIMB299

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)

(Physarum
polycephalum) 		PF09192
(Act-Frag_cataly) 		4 LEU A 193
LEU A 196
ASP A 197
ILE A 219
 None
 1.04A 2rlfB-1cjaA:
0.0
2rlfC-1cjaA:
0.0		 2rlfB-1cjaA:
9.69
2rlfC-1cjaA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb) 		4 LEU A 206
LEU A 203
ILE A 211
ARG A 210
 None
 1.09A 2rlfB-1f0xA:
0.0
2rlfC-1f0xA:
0.0		 2rlfB-1f0xA:
7.24
2rlfC-1f0xA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g03 HTLV-I CAPSID
PROTEIN

(Primate
T-lymphotropic
virus 1) 		PF00607
(Gag_p24) 		4 LEU A  58
LEU A  55
ASP A  54
ILE A  23
 None
 1.07A 2rlfB-1g03A:
0.0
2rlfC-1g03A:
undetectable		 2rlfB-1g03A:
15.38
2rlfC-1g03A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx7 HYPOTHETICAL PROTEIN
YCHN

(Escherichia
coli) 		PF02635
(DrsE) 		4 LEU A  77
LEU A  41
ILE A  87
ARG A  85
 None
 1.16A 2rlfB-1jx7A:
undetectable
2rlfC-1jx7A:
0.0		 2rlfB-1jx7A:
16.24
2rlfC-1jx7A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli) 		PF01784
(NIF3) 		4 LEU A 112
LEU A 115
TRP A 170
ILE A 191
 None
 1.15A 2rlfB-1nmoA:
0.0
2rlfC-1nmoA:
0.0		 2rlfB-1nmoA:
13.88
2rlfC-1nmoA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 253
LEU A 244
ILE A 274
ARG A 272
 None
 0.98A 2rlfB-1q8iA:
0.0
2rlfC-1q8iA:
0.0		 2rlfB-1q8iA:
4.13
2rlfC-1q8iA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qp8 FORMATE
DEHYDROGENASE

(Pyrobaculum
aerophilum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A  64
LEU A  61
ILE A  40
ARG A  39
 None
 1.06A 2rlfB-1qp8A:
0.0
2rlfC-1qp8A:
0.0		 2rlfB-1qp8A:
11.03
2rlfC-1qp8A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqg INSULIN RECEPTOR
SUBSTRATE 1

(Homo sapiens) 		PF00169
(PH)
PF02174
(IRS) 		4 LEU A  66
LEU A 113
ILE A  64
ARG A  43
 None
 1.03A 2rlfB-1qqgA:
0.0
2rlfC-1qqgA:
0.0		 2rlfB-1qqgA:
9.92
2rlfC-1qqgA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2k MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Escherichia
coli) 		no annotation 4 LEU B  90
LEU B  91
ILE B  56
ARG B  57
 None
 0.99A 2rlfB-1r2kB:
0.0
2rlfC-1r2kB:
0.0		 2rlfB-1r2kB:
15.72
2rlfC-1r2kB:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sng COG4826: SERINE
PROTEASE INHIBITOR

(Thermobifida
fusca) 		PF00079
(Serpin) 		4 LEU A 240
LEU A 243
ILE A 352
ARG A 347
 None
 1.15A 2rlfB-1sngA:
undetectable
2rlfC-1sngA:
undetectable		 2rlfB-1sngA:
5.42
2rlfC-1sngA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		4 LEU A  75
LEU A  76
ASP A  49
ILE A 248
 NAP  A3075 ( 4.2A)
None
NAP  A3075 (-4.2A)
None
 0.98A 2rlfB-1suwA:
undetectable
2rlfC-1suwA:
undetectable		 2rlfB-1suwA:
14.69
2rlfC-1suwA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE ALPHA
SUBUNIT

(Thermus
thermophilus) 		PF00676
(E1_dh) 		4 LEU A 241
LEU A  18
ASP A 239
ARG A 299
 None
 1.16A 2rlfB-1umbA:
undetectable
2rlfC-1umbA:
undetectable		 2rlfB-1umbA:
8.62
2rlfC-1umbA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 LEU B 112
LEU B 327
TRP B 331
ILE B 334
 None
 1.10A 2rlfB-1wytB:
undetectable
2rlfC-1wytB:
undetectable		 2rlfB-1wytB:
7.19
2rlfC-1wytB:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		4 LEU A  75
LEU A  76
ASP A  49
ILE A 248
 NAP  A3076 (-4.3A)
None
NAP  A3076 (-4.2A)
None
 1.09A 2rlfB-1z0uA:
undetectable
2rlfC-1z0uA:
undetectable		 2rlfB-1z0uA:
14.69
2rlfC-1z0uA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6n HYPOTHETICAL PROTEIN
PA1234

(Pseudomonas
aeruginosa) 		PF14595
(Thioredoxin_9) 		4 LEU A  49
LEU A  45
ILE A  52
ARG A  51
 None
 0.90A 2rlfB-1z6nA:
undetectable
2rlfC-1z6nA:
undetectable		 2rlfB-1z6nA:
16.15
2rlfC-1z6nA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afg ACIDIC FIBROBLAST
GROWTH FACTOR

(Homo sapiens) 		PF00167
(FGF) 		4 LEU A  23
LEU A 111
ILE A  25
ARG A  24
 None
 1.16A 2rlfB-2afgA:
undetectable
2rlfC-2afgA:
undetectable		 2rlfB-2afgA:
16.96
2rlfC-2afgA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bng MB2760

(Mycobacterium
tuberculosis) 		PF07858
(LEH) 		4 LEU A  44
LEU A 119
ILE A  54
ARG A  55
 None
 1.12A 2rlfB-2bngA:
undetectable
2rlfC-2bngA:
undetectable		 2rlfB-2bngA:
15.75
2rlfC-2bngA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv6 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MGRA

(Staphylococcus
aureus) 		PF01047
(MarR) 		4 LEU A  44
LEU A  47
ILE A 105
ARG A 106
 None
 0.94A 2rlfB-2bv6A:
undetectable
2rlfC-2bv6A:
undetectable		 2rlfB-2bv6A:
16.94
2rlfC-2bv6A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f22 BH3987

(Bacillus
halodurans) 		PF05163
(DinB) 		4 LEU A  36
LEU A  39
TRP A  25
ILE A  20
 None
 0.83A 2rlfB-2f22A:
undetectable
2rlfC-2f22A:
undetectable		 2rlfB-2f22A:
26.51
2rlfC-2f22A:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 LEU A 207
LEU A 205
ILE A 242
ARG A 237
 None
 1.14A 2rlfB-2hgsA:
undetectable
2rlfC-2hgsA:
undetectable		 2rlfB-2hgsA:
8.41
2rlfC-2hgsA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY

(Rhodobacter
sphaeroides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 215
LEU A 218
ASP A 219
ARG A 247
 None
 1.15A 2rlfB-2hzgA:
undetectable
2rlfC-2hzgA:
undetectable		 2rlfB-2hzgA:
6.48
2rlfC-2hzgA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mqb PROBABLE
BETA-LACTAMASE

(Staphylococcus
aureus) 		PF16229
(DUF4888) 		4 LEU A  94
LEU A  98
TRP A  91
ILE A 112
 None
 1.02A 2rlfB-2mqbA:
undetectable
2rlfC-2mqbA:
undetectable		 2rlfB-2mqbA:
10.46
2rlfC-2mqbA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2no2 HUNTINGTIN-INTERACTI
NG PROTEIN 1

(Homo sapiens) 		PF16515
(HIP1_clath_bdg) 		4 LEU A 517
LEU A 513
ILE A 520
ARG A 519
 None
 0.93A 2rlfB-2no2A:
undetectable
2rlfC-2no2A:
undetectable		 2rlfB-2no2A:
15.69
2rlfC-2no2A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana) 		PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 LEU A 557
LEU A 558
ASP A 547
ILE A 459
 None
 1.16A 2rlfB-2o7qA:
undetectable
2rlfC-2o7qA:
undetectable		 2rlfB-2o7qA:
5.16
2rlfC-2o7qA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 539
LEU A 540
ASP A 351
ILE A 358
 None
 1.14A 2rlfB-2ocfA:
undetectable
2rlfC-2ocfA:
undetectable		 2rlfB-2ocfA:
16.67
2rlfC-2ocfA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR
FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3)
PF00104
(Hormone_recep) 		4 LEU A 539
LEU A 540
ASP A 351
ARG D  33
 None
 1.15A 2rlfB-2ocfA:
undetectable
2rlfC-2ocfA:
undetectable		 2rlfB-2ocfA:
16.67
2rlfC-2ocfA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 LEU A 333
LEU A 336
ILE A 311
ARG A 344
 None
 0.93A 2rlfB-2ohhA:
undetectable
2rlfC-2ohhA:
undetectable		 2rlfB-2ohhA:
8.44
2rlfC-2ohhA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6r AFUHEL308 HELICASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 634
LEU A 631
ILE A 653
ARG A 654
 None
 1.13A 2rlfB-2p6rA:
undetectable
2rlfC-2p6rA:
undetectable		 2rlfB-2p6rA:
6.01
2rlfC-2p6rA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF01728
(FtsJ) 		4 LEU A  10
LEU A  13
ILE A  40
ARG A  43
 None
 1.10A 2rlfB-2plwA:
undetectable
2rlfC-2plwA:
undetectable		 2rlfB-2plwA:
12.06
2rlfC-2plwA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5o CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo sapiens) 		PF00040
(fn2)
PF00878
(CIMR) 		4 LEU A2028
LEU A2005
TRP A2015
ILE A2026
 None
 1.15A 2rlfB-2v5oA:
undetectable
2rlfC-2v5oA:
undetectable		 2rlfB-2v5oA:
5.57
2rlfC-2v5oA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		4 LEU B 450
LEU B 453
ILE B 495
ARG B 497
 None
 0.93A 2rlfB-2xwuB:
undetectable
2rlfC-2xwuB:
undetectable		 2rlfB-2xwuB:
3.57
2rlfC-2xwuB:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A  40
TRP A 453
ILE A 367
ARG A 446
 None
 0.90A 2rlfB-2ze0A:
undetectable
2rlfC-2ze0A:
undetectable		 2rlfB-2ze0A:
6.44
2rlfC-2ze0A:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvy CHEMOTAXIS PROTEIN
MOTB

(Salmonella
enterica) 		PF00691
(OmpA) 		4 LEU A 149
LEU A 144
ILE A 151
ARG A 150
 None
 1.06A 2rlfB-2zvyA:
undetectable
2rlfC-2zvyA:
undetectable		 2rlfB-2zvyA:
13.77
2rlfC-2zvyA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aii GLUTAMYL-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 LEU A 133
LEU A 131
ILE A 135
ARG A 134
 None
ACY  A 601 (-3.9A)
None
None
 1.11A 2rlfB-3aiiA:
undetectable
2rlfC-3aiiA:
undetectable		 2rlfB-3aiiA:
6.39
2rlfC-3aiiA:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		4 LEU A 179
LEU A 178
ILE A 206
ARG A 208
 None
 1.02A 2rlfB-3apoA:
undetectable
2rlfC-3apoA:
undetectable		 2rlfB-3apoA:
6.37
2rlfC-3apoA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		4 LEU A 130
LEU A 133
ILE A 144
ARG A 140
 None
 0.98A 2rlfB-3auoA:
undetectable
2rlfC-3auoA:
undetectable		 2rlfB-3auoA:
6.14
2rlfC-3auoA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN

(Bifidobacterium
longum) 		PF02541
(Ppx-GppA) 		4 LEU A 328
LEU A 329
ASP A  22
ILE A 122
 SO4  A 346 (-4.2A)
None
SO4  A 346 (-3.0A)
None
 1.15A 2rlfB-3cerA:
undetectable
2rlfC-3cerA:
undetectable		 2rlfB-3cerA:
9.63
2rlfC-3cerA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2

(Escherichia
coli) 		PF00730
(HhH-GPD)
PF06029
(AlkA_N) 		4 LEU A 240
ASP A 238
TRP A 272
ILE A 271
 None
 1.14A 2rlfB-3cwuA:
undetectable
2rlfC-3cwuA:
undetectable		 2rlfB-3cwuA:
11.17
2rlfC-3cwuA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 LEU A 758
LEU A 691
ILE A 761
ARG A 792
 None
 1.04A 2rlfB-3ecqA:
undetectable
2rlfC-3ecqA:
undetectable		 2rlfB-3ecqA:
2.83
2rlfC-3ecqA:
2.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etl DNA REPAIR AND
RECOMBINATION
PROTEIN RADA

(Methanococcus
maripaludis) 		PF08423
(Rad51)
PF14520
(HHH_5) 		4 LEU A  87
LEU A  91
ASP A  88
ILE A 320
 None
 1.01A 2rlfB-3etlA:
undetectable
2rlfC-3etlA:
undetectable		 2rlfB-3etlA:
9.88
2rlfC-3etlA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g04 THYROTROPIN RECEPTOR

(Homo sapiens) 		PF13306
(LRR_5) 		4 LEU C  64
LEU C  89
ASP C  86
ILE C  44
 None
 1.16A 2rlfB-3g04C:
undetectable
2rlfC-3g04C:
undetectable		 2rlfB-3g04C:
10.43
2rlfC-3g04C:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gem SHORT CHAIN
DEHYDROGENASE

(Pseudomonas
savastanoi) 		PF13561
(adh_short_C2) 		4 LEU A 217
LEU A 216
ASP A 129
ILE A   8
 None
 1.13A 2rlfB-3gemA:
undetectable
2rlfC-3gemA:
undetectable		 2rlfB-3gemA:
11.02
2rlfC-3gemA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf6 UNCHARACTERIZED
BACTERIAL
LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12956
(DUF3845) 		4 LEU A 227
LEU A 142
ILE A 229
ARG A 228
 None
None
None
EDO  A   6 (-3.9A)
 1.12A 2rlfB-3gf6A:
undetectable
2rlfC-3gf6A:
undetectable		 2rlfB-3gf6A:
12.00
2rlfC-3gf6A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		4 LEU A 183
LEU A 184
ASP A 175
ILE A 273
 None
None
SAH  A 401 ( 4.2A)
None
 0.75A 2rlfB-3i58A:
undetectable
2rlfC-3i58A:
undetectable		 2rlfB-3i58A:
9.52
2rlfC-3i58A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8g GTPASE DER

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		4 LEU X 306
LEU X 303
ASP X 302
ILE X 318
 None
U  B2076 ( 4.0A)
None
None
 0.85A 2rlfB-3j8gX:
undetectable
2rlfC-3j8gX:
undetectable		 2rlfB-3j8gX:
8.33
2rlfC-3j8gX:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		4 LEU A 505
LEU A 504
ILE A 470
ARG A 468
 None
 0.97A 2rlfB-3k13A:
undetectable
2rlfC-3k13A:
undetectable		 2rlfB-3k13A:
10.43
2rlfC-3k13A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqb LOC792177 PROTEIN

(Danio rerio) 		PF01400
(Astacin) 		4 LEU A 185
LEU A 152
ILE A 193
ARG A 192
 None
 0.97A 2rlfB-3lqbA:
undetectable
2rlfC-3lqbA:
undetectable		 2rlfB-3lqbA:
9.55
2rlfC-3lqbA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxq UNCHARACTERIZED
PROTEIN VP1736

(Vibrio
parahaemolyticus) 		PF00884
(Sulfatase) 		4 LEU A 368
LEU A 367
ILE A 553
ARG A 284
 None
 0.96A 2rlfB-3lxqA:
undetectable
2rlfC-3lxqA:
undetectable		 2rlfB-3lxqA:
8.23
2rlfC-3lxqA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 LEU A  42
LEU A 474
ILE A 666
ARG A 667
 None
 0.98A 2rlfB-3ne5A:
1.3
2rlfC-3ne5A:
undetectable		 2rlfB-3ne5A:
3.94
2rlfC-3ne5A:
3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 LEU B 734
LEU B 737
ILE B 494
ARG B 493
 None
 0.70A 2rlfB-3o8oB:
undetectable
2rlfC-3o8oB:
undetectable		 2rlfB-3o8oB:
5.11
2rlfC-3o8oB:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oet ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Salmonella
enterica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		4 LEU A 103
LEU A 106
ILE A 119
ARG A 117
 None
 0.94A 2rlfB-3oetA:
undetectable
2rlfC-3oetA:
undetectable		 2rlfB-3oetA:
11.24
2rlfC-3oetA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae) 		PF13855
(LRR_8) 		4 LEU B 334
LEU B 331
ILE B 336
ARG B 354
 None
 1.01A 2rlfB-3ojaB:
undetectable
2rlfC-3ojaB:
undetectable		 2rlfB-3ojaB:
5.13
2rlfC-3ojaB:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE

(Maricaulis
maris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		4 LEU A 257
LEU A 260
ILE A 288
ARG A 289
 None
 1.07A 2rlfB-3s6hA:
undetectable
2rlfC-3s6hA:
undetectable		 2rlfB-3s6hA:
6.90
2rlfC-3s6hA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Mus musculus) 		PF04389
(Peptidase_M28) 		4 LEU A  74
LEU A  71
ILE A  92
ARG A  95
 None
 0.76A 2rlfB-3si1A:
undetectable
2rlfC-3si1A:
undetectable		 2rlfB-3si1A:
12.35
2rlfC-3si1A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3su8 PLEXIN-B1

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		4 LEU X1958
ASP X1959
ILE X2056
ARG X2057
 None
 1.17A 2rlfB-3su8X:
undetectable
2rlfC-3su8X:
undetectable		 2rlfB-3su8X:
6.09
2rlfC-3su8X:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkt CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 LEU A 393
LEU A 396
ILE A 305
ARG A 299
 None
 1.10A 2rlfB-3tktA:
undetectable
2rlfC-3tktA:
undetectable		 2rlfB-3tktA:
6.59
2rlfC-3tktA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v78 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
DEOR-FAMILY)

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 LEU A 114
LEU A 111
ILE A  27
ARG A  29
 None
ET  A 301 ( 4.3A)
None
None
 0.93A 2rlfB-3v78A:
undetectable
2rlfC-3v78A:
undetectable		 2rlfB-3v78A:
11.06
2rlfC-3v78A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x27 CUCUMOPINE SYNTHASE

(Marinactinospora
thermotolerans) 		no annotation 4 LEU A  31
LEU A  35
ILE A   4
ARG A 139
 None
 1.07A 2rlfB-3x27A:
undetectable
2rlfC-3x27A:
undetectable		 2rlfB-3x27A:
7.49
2rlfC-3x27A:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpx LIPASE

(Ustilago maydis) 		PF03583
(LIP) 		4 LEU A 295
ASP A 292
ILE A 252
ARG A 255
 None
 1.04A 2rlfB-3zpxA:
undetectable
2rlfC-3zpxA:
undetectable		 2rlfB-3zpxA:
8.31
2rlfC-3zpxA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ars HISTIDINE ACID
PHOSPHATASE

(Hafnia alvei) 		PF00328
(His_Phos_2) 		4 LEU A 126
ASP A 124
TRP A  88
ILE A 303
 None
 1.08A 2rlfB-4arsA:
undetectable
2rlfC-4arsA:
undetectable		 2rlfB-4arsA:
5.72
2rlfC-4arsA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Caulobacter sp.
K31) 		PF01532
(Glyco_hydro_47) 		4 LEU A  78
LEU A  80
ASP A  59
ILE A  73
 None
 1.02A 2rlfB-4ayrA:
undetectable
2rlfC-4ayrA:
undetectable		 2rlfB-4ayrA:
6.78
2rlfC-4ayrA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9a PROBABLE EPOXIDE
HYDROLASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		4 LEU A 288
LEU A 292
ILE A  49
ARG A  52
 None
 1.03A 2rlfB-4b9aA:
undetectable
2rlfC-4b9aA:
undetectable		 2rlfB-4b9aA:
8.97
2rlfC-4b9aA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		4 LEU A 297
LEU A 300
ASP A 301
TRP A 366
 LEU  A 297 ( 0.5A)
LEU  A 300 ( 0.5A)
ASP  A 301 ( 0.6A)
TRP  A 366 ( 0.5A)
 1.08A 2rlfB-4hneA:
undetectable
2rlfC-4hneA:
undetectable		 2rlfB-4hneA:
7.42
2rlfC-4hneA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
putida) 		PF00899
(ThiF)
PF08501
(Shikimate_dh_N) 		4 LEU A 233
LEU A 234
ASP A 223
ILE A 131
 None
None
None
MN  A 302 (-4.6A)
 1.09A 2rlfB-4k28A:
undetectable
2rlfC-4k28A:
undetectable		 2rlfB-4k28A:
10.89
2rlfC-4k28A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k68 GH10 XYLANASE

(soil metagenome) 		PF00331
(Glyco_hydro_10) 		4 LEU A 260
LEU A 257
ILE A 220
ARG A 217
 None
 1.05A 2rlfB-4k68A:
undetectable
2rlfC-4k68A:
undetectable		 2rlfB-4k68A:
7.39
2rlfC-4k68A:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 LEU A 570
LEU A 784
TRP A 788
ILE A 791
 None
 1.11A 2rlfB-4lglA:
undetectable
2rlfC-4lglA:
undetectable		 2rlfB-4lglA:
4.49
2rlfC-4lglA:
4.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lqc TCPB

(Brucella
melitensis) 		PF13676
(TIR_2) 		4 LEU A 196
LEU A 193
ILE A 165
ARG A 162
 None
 1.00A 2rlfB-4lqcA:
undetectable
2rlfC-4lqcA:
undetectable		 2rlfB-4lqcA:
21.43
2rlfC-4lqcA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my0 GCN5-RELATED
N-ACETYLTRANSFERASE

(Kribbella
flavida) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 LEU A 386
ASP A 387
TRP A 187
ILE A 192
 None
 0.98A 2rlfB-4my0A:
undetectable
2rlfC-4my0A:
undetectable		 2rlfB-4my0A:
7.45
2rlfC-4my0A:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1

(Escherichia
coli;
Homo sapiens) 		PF00003
(7tm_3)
PF07361
(Cytochrom_B562) 		4 LEU A1010
LEU A1014
TRP A1007
ILE A1102
 None
 0.95A 2rlfB-4or2A:
undetectable
2rlfC-4or2A:
undetectable		 2rlfB-4or2A:
11.28
2rlfC-4or2A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4quv DELTA(14)-STEROL
REDUCTASE

(Methylomicrobium
alcaliphilum) 		PF01222
(ERG4_ERG24) 		4 LEU A 404
ASP A 400
TRP A 411
ARG A 356
 None
 1.00A 2rlfB-4quvA:
undetectable
2rlfC-4quvA:
undetectable		 2rlfB-4quvA:
6.73
2rlfC-4quvA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry1 PERIPLASMIC SOLUTE
BINDING PROTEIN

(Pectobacterium
atrosepticum) 		PF13416
(SBP_bac_8) 		4 LEU A 409
LEU A 412
ASP A 413
ILE A 199
 None
 1.12A 2rlfB-4ry1A:
undetectable
2rlfC-4ry1A:
undetectable		 2rlfB-4ry1A:
11.38
2rlfC-4ry1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6u COG5

(Kluyveromyces
lactis) 		PF10392
(COG5) 		4 LEU B 211
LEU B 207
ILE B 228
ARG B 227
 None
 1.07A 2rlfB-4u6uB:
undetectable
2rlfC-4u6uB:
undetectable		 2rlfB-4u6uB:
10.60
2rlfC-4u6uB:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 444
LEU A 447
ILE A 413
ARG A 411
 None
 0.92A 2rlfB-4udrA:
undetectable
2rlfC-4udrA:
undetectable		 2rlfB-4udrA:
6.68
2rlfC-4udrA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA

(Escherichia
virus T4;
Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		4 LEU A 293
LEU A 296
ASP A 297
TRP A 364
 None
 0.95A 2rlfB-4wtvA:
undetectable
2rlfC-4wtvA:
undetectable		 2rlfB-4wtvA:
6.49
2rlfC-4wtvA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xch S-RIBOSYLHOMOCYSTEIN
E LYASE

(Streptococcus
suis) 		PF02664
(LuxS) 		4 LEU A  63
LEU A  62
ILE A 103
ARG A  70
 None
 0.64A 2rlfB-4xchA:
undetectable
2rlfC-4xchA:
undetectable		 2rlfB-4xchA:
12.89
2rlfC-4xchA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		no annotation 4 LEU E 386
LEU E 389
ILE E 625
ARG E 628
 None
 0.97A 2rlfB-4xmmE:
undetectable
2rlfC-4xmmE:
undetectable		 2rlfB-4xmmE:
4.53
2rlfC-4xmmE:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 LEU A 758
LEU A 691
ILE A 761
ARG A 792
 None
 1.04A 2rlfB-5a55A:
undetectable
2rlfC-5a55A:
undetectable		 2rlfB-5a55A:
5.24
2rlfC-5a55A:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		4 LEU C 269
LEU C 268
ASP C 390
ILE C 396
 None
 1.09A 2rlfB-5aa5C:
undetectable
2rlfC-5aa5C:
undetectable		 2rlfB-5aa5C:
6.54
2rlfC-5aa5C:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 929
LEU A 932
ILE A 845
ARG A 916
 None
 1.17A 2rlfB-5b7iA:
undetectable
2rlfC-5b7iA:
undetectable		 2rlfB-5b7iA:
4.77
2rlfC-5b7iA:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1p ATP-DEPENDENT RNA
LIGASE

(Methanothermobacter
thermautotrophicus) 		PF09414
(RNA_ligase) 		4 LEU A 342
LEU A 345
ILE A 361
ARG A 363
 None
 1.16A 2rlfB-5d1pA:
undetectable
2rlfC-5d1pA:
undetectable		 2rlfB-5d1pA:
7.94
2rlfC-5d1pA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 4 LEU B 500
LEU B 496
ILE B 539
ARG B 503
 None
 1.15A 2rlfB-5dlqB:
undetectable
2rlfC-5dlqB:
undetectable		 2rlfB-5dlqB:
3.24
2rlfC-5dlqB:
3.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eut PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA,ENDOLYSIN,PH
OSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Escherichia
virus T4;
Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		4 LEU A 297
LEU A 300
ASP A 301
TRP A 366
 None
 1.01A 2rlfB-5eutA:
undetectable
2rlfC-5eutA:
undetectable		 2rlfB-5eutA:
13.23
2rlfC-5eutA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwm HEAT SHOCK PROTEIN
HSP 90 BETA

(Homo sapiens) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 657
LEU A 654
ILE A 680
ARG A 682
 None
 0.88A 2rlfB-5fwmA:
undetectable
2rlfC-5fwmA:
undetectable		 2rlfB-5fwmA:
6.35
2rlfC-5fwmA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 4 LEU A 409
LEU A 406
ASP A 405
ILE A 459
 None
 1.11A 2rlfB-5h7jA:
undetectable
2rlfC-5h7jA:
undetectable		 2rlfB-5h7jA:
17.57
2rlfC-5h7jA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlh MARR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Staphylococcus
epidermidis) 		PF01047
(MarR) 		4 LEU A  76
LEU A  73
ILE A  36
ARG A  75
 None
 1.07A 2rlfB-5hlhA:
undetectable
2rlfC-5hlhA:
undetectable		 2rlfB-5hlhA:
16.30
2rlfC-5hlhA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		4 LEU A 153
LEU A 149
ILE A 226
ARG A 225
 None
None
None
CL  A 503 (-3.0A)
 0.91A 2rlfB-5iuyA:
undetectable
2rlfC-5iuyA:
undetectable		 2rlfB-5iuyA:
7.03
2rlfC-5iuyA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB6

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF01192
(RNA_pol_Rpb6)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU F  90
LEU F  91
ASP F  88
ILE A 455
 None
 1.10A 2rlfB-5iy9F:
undetectable
2rlfC-5iy9F:
undetectable		 2rlfB-5iy9F:
16.13
2rlfC-5iy9F:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j47 LARGE T ANTIGEN

(Human
polyomavirus 2) 		PF06431
(Polyoma_lg_T_C) 		4 LEU A 370
LEU A 369
TRP A 600
ILE A 597
 None
 0.94A 2rlfB-5j47A:
undetectable
2rlfC-5j47A:
undetectable		 2rlfB-5j47A:
7.53
2rlfC-5j47A:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE

(Streptomyces
sp. MJ635-86F5) 		PF00501
(AMP-binding) 		4 LEU A 300
LEU A 303
ILE A 285
ARG A 307
 None
 0.94A 2rlfB-5jjpA:
undetectable
2rlfC-5jjpA:
undetectable		 2rlfB-5jjpA:
6.22
2rlfC-5jjpA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 792
LEU A 167
ASP A 164
ARG A 630
 None
 1.13A 2rlfB-5ju6A:
undetectable
2rlfC-5ju6A:
undetectable		 2rlfB-5ju6A:
5.32
2rlfC-5ju6A:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y RIBOSOMAL PROTEIN S9
(PREDICTED)

(Oryctolagus
cuniculus) 		PF00163
(Ribosomal_S4)
PF01479
(S4) 		4 LEU K  81
LEU K  77
ILE K  84
ARG K  83
 None
None
None
U  A 816 ( 3.4A)
 1.17A 2rlfB-5k0yK:
undetectable
2rlfC-5k0yK:
undetectable		 2rlfB-5k0yK:
13.41
2rlfC-5k0yK:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE

(Astrosporangium
hypotensionis) 		PF01432
(Peptidase_M3) 		4 LEU A 167
LEU A 163
ILE A 263
ARG A 262
 None
 1.11A 2rlfB-5l44A:
undetectable
2rlfC-5l44A:
undetectable		 2rlfB-5l44A:
5.65
2rlfC-5l44A:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU A 566
LEU A 563
ILE A 521
ARG A 606
 None
 1.02A 2rlfB-5m59A:
undetectable
2rlfC-5m59A:
undetectable		 2rlfB-5m59A:
2.52
2rlfC-5m59A:
2.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nwm NUCLEAR RECEPTOR
COACTIVATOR 1
SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6

(Homo sapiens) 		no annotation 4 LEU B 805
LEU B 802
ASP B 801
ILE A 273
 None
 1.06A 2rlfB-5nwmB:
undetectable
2rlfC-5nwmB:
undetectable		 2rlfB-5nwmB:
19.51
2rlfC-5nwmB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 491
LEU A 492
ASP A 489
TRP A 335
 None
 1.16A 2rlfB-5toaA:
undetectable
2rlfC-5toaA:
undetectable		 2rlfB-5toaA:
14.47
2rlfC-5toaA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1
CRISPR-ASSOCIATED
PROTEIN CSY2

(Pseudomonas
aeruginosa) 		PF09611
(Cas_Csy1)
PF09614
(Cas_Csy2) 		4 LEU A 264
LEU A 265
TRP B  29
ILE B  23
 None
 1.04A 2rlfB-5uz9A:
undetectable
2rlfC-5uz9A:
undetectable		 2rlfB-5uz9A:
9.43
2rlfC-5uz9A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 LEU A 307
LEU A 419
ILE A 303
ARG A 304
 None
 1.15A 2rlfB-6bpcA:
undetectable
2rlfC-6bpcA:
undetectable		 2rlfB-6bpcA:
17.74
2rlfC-6bpcA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0g PIRIN FAMILY PROTEIN

(Acinetobacter
baumannii) 		no annotation 4 LEU A 204
LEU A 238
ILE A 202
ARG A 201
 None
 1.09A 2rlfB-6d0gA:
undetectable
2rlfC-6d0gA:
undetectable		 2rlfB-6d0gA:
21.33
2rlfC-6d0gA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE

(Homo sapiens) 		no annotation 4 LEU A 392
LEU A 388
ILE A 423
ARG A 422
 None
 1.10A 2rlfB-6dd3A:
undetectable
2rlfC-6dd3A:
undetectable		 2rlfB-6dd3A:
17.95
2rlfC-6dd3A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza B
virus) 		no annotation 4 LEU B  89
LEU B  92
ASP B  93
ILE A 233
 None
 1.16A 2rlfB-6f5oB:
undetectable
2rlfC-6f5oB:
undetectable		 2rlfB-6f5oB:
13.51
2rlfC-6f5oB:
13.51