SIMILAR PATTERNS OF AMINO ACIDS FOR 2RLF_A_RIMA199

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)

(Physarum
polycephalum) 		PF09192
(Act-Frag_cataly) 		4 LEU A 193
LEU A 196
ASP A 197
ILE A 219
 None
 0.94A 2rlfA-1cjaA:
0.0
2rlfB-1cjaA:
0.0		 2rlfA-1cjaA:
9.69
2rlfB-1cjaA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnt OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		4 LEU A 267
LEU A 307
ILE A 263
ARG A 309
 None
 1.07A 2rlfA-1nntA:
undetectable
2rlfB-1nntA:
0.0		 2rlfA-1nntA:
8.12
2rlfB-1nntA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1of3 BETA-MANNOSIDASE

(Thermotoga
maritima) 		PF09212
(CBM27) 		4 LEU A 147
LEU A 100
ILE A 149
ARG A  64
 None
 0.80A 2rlfA-1of3A:
undetectable
2rlfB-1of3A:
undetectable		 2rlfA-1of3A:
14.53
2rlfB-1of3A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT

(Homo sapiens) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU B 275
LEU B 276
ILE B 291
ARG B 309
 None
 1.01A 2rlfA-1olxB:
0.0
2rlfB-1olxB:
0.0		 2rlfA-1olxB:
11.42
2rlfB-1olxB:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 LEU A 268
LEU A 267
ILE A 357
ARG A 269
 None
 0.97A 2rlfA-1pw4A:
0.0
2rlfB-1pw4A:
0.0		 2rlfA-1pw4A:
7.08
2rlfB-1pw4A:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		4 LEU A  27
LEU A  56
ILE A  51
ARG A  52
 None
None
None
XYP  A 601 ( 4.9A)
 0.93A 2rlfA-1px8A:
0.0
2rlfB-1px8A:
0.0		 2rlfA-1px8A:
7.14
2rlfB-1px8A:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py9 MYELIN-OLIGODENDROCY
TE GLYCOPROTEIN

(Mus musculus) 		PF07686
(V-set) 		4 LEU A  83
LEU A  71
ILE A  85
ARG A  84
 None
 1.04A 2rlfA-1py9A:
0.0
2rlfB-1py9A:
undetectable		 2rlfA-1py9A:
16.22
2rlfB-1py9A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1

(Bos taurus) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		4 LEU A 206
LEU A 211
ILE A 215
ARG A 170
 None
 0.99A 2rlfA-1pztA:
0.0
2rlfB-1pztA:
0.0		 2rlfA-1pztA:
9.75
2rlfB-1pztA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 253
LEU A 244
ILE A 274
ARG A 272
 None
 1.05A 2rlfA-1q8iA:
0.0
2rlfB-1q8iA:
0.0		 2rlfA-1q8iA:
4.13
2rlfB-1q8iA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5m SIR4-INTERACTING
PROTEIN SIF2

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 LEU A 374
LEU A 375
ILE A 341
ARG A 384
 None
 0.91A 2rlfA-1r5mA:
undetectable
2rlfB-1r5mA:
undetectable		 2rlfA-1r5mA:
7.84
2rlfB-1r5mA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tu3 RAB GTPASE BINDING
EFFECTOR PROTEIN 1

(Homo sapiens) 		PF09311
(Rab5-bind) 		4 LEU F 832
LEU F 828
ILE F 835
ARG F 834
 None
 0.89A 2rlfA-1tu3F:
2.5
2rlfB-1tu3F:
2.2		 2rlfA-1tu3F:
13.92
2rlfB-1tu3F:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi6 30S RIBOSOMAL
PROTEIN S2P

(Archaeoglobus
fulgidus) 		PF00318
(Ribosomal_S2) 		4 LEU A  51
LEU A  46
ILE A  55
ARG A  54
 None
 0.99A 2rlfA-1vi6A:
undetectable
2rlfB-1vi6A:
undetectable		 2rlfA-1vi6A:
11.54
2rlfB-1vi6A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8a SLIT PROTEIN

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 LEU A 607
LEU A 582
ILE A 610
ARG A 584
 None
 1.04A 2rlfA-1w8aA:
undetectable
2rlfB-1w8aA:
undetectable		 2rlfA-1w8aA:
15.66
2rlfB-1w8aA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa6 BETA2-CHIMAERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		4 LEU A 266
ASP A 265
ILE A 269
ARG A 268
 None
 0.93A 2rlfA-1xa6A:
undetectable
2rlfB-1xa6A:
undetectable		 2rlfA-1xa6A:
8.57
2rlfB-1xa6A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0y FRV OPERON PROTEIN
FRVX

(Pyrococcus
horikoshii) 		PF05343
(Peptidase_M42) 		4 LEU A  12
LEU A  11
ILE A 185
ARG A 184
 None
 1.04A 2rlfA-1y0yA:
undetectable
2rlfB-1y0yA:
undetectable		 2rlfA-1y0yA:
8.31
2rlfB-1y0yA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yix DEOXYRIBONUCLEASE
YCFH

(Escherichia
coli) 		PF01026
(TatD_DNase) 		4 LEU A 200
LEU A 197
ILE A 174
ARG A 199
 None
 0.99A 2rlfA-1yixA:
undetectable
2rlfB-1yixA:
undetectable		 2rlfA-1yixA:
11.49
2rlfB-1yixA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0h TALIN-1

(Mus musculus) 		PF08913
(VBS) 		4 LEU A1968
LEU A1965
ILE A1916
ARG A1919
 None
 0.70A 2rlfA-2b0hA:
undetectable
2rlfB-2b0hA:
undetectable		 2rlfA-2b0hA:
20.37
2rlfB-2b0hA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		4 LEU A  27
LEU A  56
ILE A  51
ARG A  52
 None
 0.99A 2rlfA-2bs9A:
undetectable
2rlfB-2bs9A:
undetectable		 2rlfA-2bs9A:
7.32
2rlfB-2bs9A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csj TJP2 PROTEIN

(Mus musculus) 		PF00595
(PDZ) 		4 LEU A  63
ASP A  67
ILE A  48
ARG A  68
 None
 1.03A 2rlfA-2csjA:
undetectable
2rlfB-2csjA:
undetectable		 2rlfA-2csjA:
12.38
2rlfB-2csjA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f22 BH3987

(Bacillus
halodurans) 		PF05163
(DinB) 		4 LEU A  36
LEU A  39
TRP A  25
ILE A  20
 None
 0.64A 2rlfA-2f22A:
undetectable
2rlfB-2f22A:
undetectable		 2rlfA-2f22A:
26.51
2rlfB-2f22A:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE

(Pseudomonas
putida) 		PF04909
(Amidohydro_2) 		4 LEU A 142
LEU A 111
ILE A 149
ARG A 144
 None
 1.05A 2rlfA-2ffiA:
undetectable
2rlfB-2ffiA:
undetectable		 2rlfA-2ffiA:
9.76
2rlfB-2ffiA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 LEU A 426
LEU A 449
ILE A 428
ARG A 125
 None
None
None
SO4  A 505 ( 3.0A)
 1.07A 2rlfA-2hgsA:
undetectable
2rlfB-2hgsA:
undetectable		 2rlfA-2hgsA:
8.41
2rlfB-2hgsA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Staphylococcus
aureus) 		PF00005
(ABC_tran) 		4 LEU A 185
LEU A 182
ILE A 153
ARG A 150
 None
 0.71A 2rlfA-2ihyA:
undetectable
2rlfB-2ihyA:
undetectable		 2rlfA-2ihyA:
10.39
2rlfB-2ihyA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfk CELL DIVISION
CONTROL PROTEIN 24

(Saccharomyces
cerevisiae) 		PF00564
(PB1) 		4 LEU B 118
LEU B 119
ILE B 109
ARG B 108
 None
 1.04A 2rlfA-2kfkB:
undetectable
2rlfB-2kfkB:
undetectable		 2rlfA-2kfkB:
20.25
2rlfB-2kfkB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kvp TALIN-1

(Mus musculus) 		PF08913
(VBS) 		4 LEU A1968
LEU A1965
ILE A1916
ARG A1919
 None
 0.86A 2rlfA-2kvpA:
undetectable
2rlfB-2kvpA:
undetectable		 2rlfA-2kvpA:
20.37
2rlfB-2kvpA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU A  85
LEU A 108
ILE A  88
ARG A  87
 None
 0.93A 2rlfA-2oq5A:
undetectable
2rlfB-2oq5A:
undetectable		 2rlfA-2oq5A:
10.92
2rlfB-2oq5A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3h UNCHARACTERIZED CBS
DOMAIN-CONTAINING
PROTEIN

(Corynebacterium
glutamicum) 		PF03471
(CorC_HlyC) 		4 LEU A  82
LEU A 101
ILE A  84
ARG A  83
 None
 1.03A 2rlfA-2p3hA:
undetectable
2rlfB-2p3hA:
undetectable		 2rlfA-2p3hA:
22.77
2rlfB-2p3hA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6p GLYCOSYL TRANSFERASE

(Streptomyces
fradiae) 		PF06722
(DUF1205) 		4 LEU A 293
LEU A 296
ILE A 173
ARG A 190
 None
 1.00A 2rlfA-2p6pA:
undetectable
2rlfB-2p6pA:
undetectable		 2rlfA-2p6pA:
9.80
2rlfB-2p6pA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9q DNA REPLICATION
COMPLEX GINS PROTEIN
PSF1

(Homo sapiens) 		no annotation 4 LEU C  84
LEU C  80
ILE C  87
ARG C  86
 None
 0.98A 2rlfA-2q9qC:
undetectable
2rlfB-2q9qC:
undetectable		 2rlfA-2q9qC:
12.90
2rlfB-2q9qC:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		4 LEU A 368
LEU A 364
ILE A 371
ARG A 370
 None
 0.83A 2rlfA-2w3pA:
undetectable
2rlfB-2w3pA:
undetectable		 2rlfA-2w3pA:
5.55
2rlfB-2w3pA:
5.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7a LINE-1 ORF1P

(Homo sapiens) 		PF02994
(Transposase_22) 		4 LEU A 160
LEU A 158
ILE A 247
ARG A 248
 None
 1.05A 2rlfA-2w7aA:
undetectable
2rlfB-2w7aA:
undetectable		 2rlfA-2w7aA:
16.48
2rlfB-2w7aA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xac VASCULAR ENDOTHELIAL
GROWTH FACTOR B

(Homo sapiens) 		PF00341
(PDGF) 		4 LEU A  81
LEU A  90
ILE A  83
ARG A  84
 None
 1.06A 2rlfA-2xacA:
undetectable
2rlfB-2xacA:
undetectable		 2rlfA-2xacA:
13.40
2rlfB-2xacA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 LEU A  70
LEU A  68
ILE A  78
ARG A  79
 None
 1.01A 2rlfA-2xvgA:
undetectable
2rlfB-2xvgA:
undetectable		 2rlfA-2xvgA:
3.53
2rlfB-2xvgA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvy CHEMOTAXIS PROTEIN
MOTB

(Salmonella
enterica) 		PF00691
(OmpA) 		4 LEU A 149
LEU A 144
ILE A 151
ARG A 150
 None
 1.00A 2rlfA-2zvyA:
undetectable
2rlfB-2zvyA:
undetectable		 2rlfA-2zvyA:
13.77
2rlfB-2zvyA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etl DNA REPAIR AND
RECOMBINATION
PROTEIN RADA

(Methanococcus
maripaludis) 		PF08423
(Rad51)
PF14520
(HHH_5) 		4 LEU A  87
LEU A  91
ASP A  88
ILE A 320
 None
 1.03A 2rlfA-3etlA:
undetectable
2rlfB-3etlA:
undetectable		 2rlfA-3etlA:
9.88
2rlfB-3etlA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ha4 MIX1

(Leishmania
major) 		no annotation 4 LEU A  78
LEU A  77
TRP A  75
ILE A 112
 None
 0.99A 2rlfA-3ha4A:
undetectable
2rlfB-3ha4A:
undetectable		 2rlfA-3ha4A:
14.60
2rlfB-3ha4A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		4 LEU A 183
LEU A 184
ASP A 175
ILE A 273
 None
None
SAH  A 401 ( 4.2A)
None
 0.74A 2rlfA-3i58A:
undetectable
2rlfB-3i58A:
undetectable		 2rlfA-3i58A:
9.52
2rlfB-3i58A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq2 SORTING NEXIN-7

(Homo sapiens) 		PF00787
(PX) 		4 LEU A 125
LEU A 121
ILE A 128
ARG A 127
 None
 0.78A 2rlfA-3iq2A:
undetectable
2rlfB-3iq2A:
undetectable		 2rlfA-3iq2A:
20.18
2rlfB-3iq2A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isp HTH-TYPE
TRANSCRIPTIONAL
REGULATOR
RV1985C/MT2039

(Mycobacterium
tuberculosis) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 LEU A  14
LEU A  11
ILE A  41
ARG A  40
 None
 0.99A 2rlfA-3ispA:
undetectable
2rlfB-3ispA:
undetectable		 2rlfA-3ispA:
8.53
2rlfB-3ispA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jys SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A  82
LEU A  81
ILE A 304
ARG A  83
 None
 1.01A 2rlfA-3jysA:
undetectable
2rlfB-3jysA:
undetectable		 2rlfA-3jysA:
6.56
2rlfB-3jysA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1

(Ehrlichia
chaffeensis) 		PF13419
(HAD_2) 		4 LEU A  94
LEU A  91
ILE A 204
ARG A 201
 None
 0.89A 2rlfA-3kzxA:
undetectable
2rlfB-3kzxA:
undetectable		 2rlfA-3kzxA:
23.96
2rlfB-3kzxA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqb LOC792177 PROTEIN

(Danio rerio) 		PF01400
(Astacin) 		4 LEU A 185
LEU A 152
ILE A 193
ARG A 192
 None
 0.89A 2rlfA-3lqbA:
undetectable
2rlfB-3lqbA:
undetectable		 2rlfA-3lqbA:
9.55
2rlfB-3lqbA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7n PUTATIVE
UNCHARACTERIZED
PROTEIN AF_0206

(Archaeoglobus
fulgidus) 		PF10447
(EXOSC1)
PF14382
(ECR1_N) 		4 LEU A 118
LEU A 139
ILE A  75
ARG A  64
 None
 1.06A 2rlfA-3m7nA:
undetectable
2rlfB-3m7nA:
undetectable		 2rlfA-3m7nA:
16.87
2rlfB-3m7nA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mix FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Bacillus
subtilis) 		PF00771
(FHIPEP) 		4 LEU A 381
LEU A 375
ILE A 532
ARG A 533
 None
 0.98A 2rlfA-3mixA:
undetectable
2rlfB-3mixA:
undetectable		 2rlfA-3mixA:
8.92
2rlfB-3mixA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mue PANTOTHENATE
SYNTHETASE

(Salmonella
enterica) 		PF02569
(Pantoate_ligase) 		4 LEU A  10
LEU A   9
ILE A  14
ARG A  15
 None
 1.02A 2rlfA-3mueA:
undetectable
2rlfB-3mueA:
undetectable		 2rlfA-3mueA:
11.06
2rlfB-3mueA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE

(Methylobacillus
flagellatus) 		PF14403
(CP_ATPgrasp_2) 		4 LEU A 297
LEU A 298
ILE A 272
ARG A 274
 None
 1.04A 2rlfA-3n6xA:
undetectable
2rlfB-3n6xA:
undetectable		 2rlfA-3n6xA:
7.22
2rlfB-3n6xA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 LEU B 734
LEU B 737
ILE B 494
ARG B 493
 None
 0.78A 2rlfA-3o8oB:
undetectable
2rlfB-3o8oB:
undetectable		 2rlfA-3o8oB:
5.11
2rlfB-3o8oB:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9w GTPASE ERA

(Aquifex
aeolicus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		4 LEU A 190
LEU A 193
ILE A 221
ARG A 191
 None
 1.05A 2rlfA-3r9wA:
undetectable
2rlfB-3r9wA:
undetectable		 2rlfA-3r9wA:
9.38
2rlfB-3r9wA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Mus musculus) 		PF04389
(Peptidase_M28) 		4 LEU A  74
LEU A  71
ILE A  92
ARG A  95
 None
 1.07A 2rlfA-3si1A:
undetectable
2rlfB-3si1A:
undetectable		 2rlfA-3si1A:
12.35
2rlfB-3si1A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tj8 UREASE ACCESSORY
PROTEIN UREE

(Helicobacter
pylori) 		PF02814
(UreE_N)
PF05194
(UreE_C) 		4 LEU A 126
LEU A 123
ILE A  98
ARG A 101
 None
 0.93A 2rlfA-3tj8A:
undetectable
2rlfB-3tj8A:
undetectable		 2rlfA-3tj8A:
15.06
2rlfB-3tj8A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v67 SENSOR PROTEIN CPXA

(Vibrio
parahaemolyticus) 		PF16527
(CpxA_peri) 		4 LEU A 147
LEU A 152
ILE A  62
ARG A  59
 None
 1.05A 2rlfA-3v67A:
undetectable
2rlfB-3v67A:
undetectable		 2rlfA-3v67A:
11.97
2rlfB-3v67A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vly NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 LEU A 398
LEU A 112
ILE A 404
ARG A 397
 None
 0.90A 2rlfA-3vlyA:
undetectable
2rlfB-3vlyA:
undetectable		 2rlfA-3vlyA:
5.53
2rlfB-3vlyA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv1 PROTEIN LEC-6

(Caenorhabditis
elegans) 		PF00337
(Gal-bind_lectin) 		4 LEU A  51
LEU A  59
ILE A 131
ARG A  52
 None
 1.06A 2rlfA-3vv1A:
undetectable
2rlfB-3vv1A:
undetectable		 2rlfA-3vv1A:
16.55
2rlfB-3vv1A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4u HEMOGLOBIN SUBUNIT
ZETA

(Homo sapiens) 		PF00042
(Globin) 		4 LEU A 109
LEU A 106
ILE A  24
ARG A  31
 None
 1.05A 2rlfA-3w4uA:
undetectable
2rlfB-3w4uA:
undetectable		 2rlfA-3w4uA:
20.00
2rlfB-3w4uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Caulobacter sp.
K31) 		PF01532
(Glyco_hydro_47) 		4 LEU A  78
LEU A  80
ASP A  59
ILE A  73
 None
 1.01A 2rlfA-4ayrA:
undetectable
2rlfB-4ayrA:
undetectable		 2rlfA-4ayrA:
6.78
2rlfB-4ayrA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A 121
LEU A  72
ASP A  73
ARG A 120
 None
 0.93A 2rlfA-4bc5A:
undetectable
2rlfB-4bc5A:
undetectable		 2rlfA-4bc5A:
6.54
2rlfB-4bc5A:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be3 ALGINATE LYASE,
FAMILY PL7

(Zobellia
galactanivorans) 		PF08787
(Alginate_lyase2) 		4 LEU A 106
LEU A 296
ILE A  54
ARG A 103
 None
None
None
SRT  A 400 (-3.6A)
 1.03A 2rlfA-4be3A:
undetectable
2rlfB-4be3A:
undetectable		 2rlfA-4be3A:
8.17
2rlfB-4be3A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g09 HISTIDINOL
DEHYDROGENASE

(Brucella suis) 		PF00815
(Histidinol_dh) 		4 LEU A  49
LEU A  50
ASP A  46
ILE A 203
 None
 1.05A 2rlfA-4g09A:
undetectable
2rlfB-4g09A:
undetectable		 2rlfA-4g09A:
7.95
2rlfB-4g09A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 LEU A 173
LEU A  79
ILE A 175
ARG A 176
 None
 1.03A 2rlfA-4jklA:
undetectable
2rlfB-4jklA:
undetectable		 2rlfA-4jklA:
4.75
2rlfB-4jklA:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lqc TCPB

(Brucella
melitensis) 		PF13676
(TIR_2) 		4 LEU A 196
LEU A 193
ILE A 165
ARG A 162
 None
 1.05A 2rlfA-4lqcA:
undetectable
2rlfB-4lqcA:
undetectable		 2rlfA-4lqcA:
21.43
2rlfB-4lqcA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtp RNA DEPENDENT RNA
POLYMERASE

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5) 		4 LEU A 491
LEU A 494
ILE A 571
ARG A 602
 LEU  A 491 ( 0.6A)
LEU  A 494 ( 0.6A)
ILE  A 571 ( 0.7A)
ARG  A 602 ( 0.6A)
 0.94A 2rlfA-4mtpA:
undetectable
2rlfB-4mtpA:
undetectable		 2rlfA-4mtpA:
4.94
2rlfB-4mtpA:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pka PATATIN-17

(Solanum
cardiophyllum) 		PF01734
(Patatin) 		4 LEU X  48
LEU X  51
ILE X  86
ARG X  65
 None
 0.96A 2rlfA-4pkaX:
undetectable
2rlfB-4pkaX:
undetectable		 2rlfA-4pkaX:
7.99
2rlfB-4pkaX:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhi UNCHARACTERIZED
PROTEIN MJ1213

(Methanocaldococcus
jannaschii) 		PF01435
(Peptidase_M48) 		4 LEU A  67
LEU A  71
ILE A  63
ARG A  64
 None
 1.05A 2rlfA-4qhiA:
undetectable
2rlfB-4qhiA:
undetectable		 2rlfA-4qhiA:
21.50
2rlfB-4qhiA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		4 LEU A   9
LEU A  12
ILE A  26
ARG A  67
 None
 0.93A 2rlfA-4r04A:
undetectable
2rlfB-4r04A:
undetectable		 2rlfA-4r04A:
2.59
2rlfB-4r04A:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU A  85
LEU A 108
ILE A  88
ARG A  87
 None
 0.83A 2rlfA-4r0iA:
undetectable
2rlfB-4r0iA:
undetectable		 2rlfA-4r0iA:
9.75
2rlfB-4r0iA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnl POSSIBLE GALACTOSE
MUTAROTASE

(Streptomyces
platensis) 		PF01263
(Aldose_epim) 		4 LEU A 160
LEU A 155
ILE A 162
ARG A 161
 None
 1.07A 2rlfA-4rnlA:
undetectable
2rlfB-4rnlA:
undetectable		 2rlfA-4rnlA:
10.95
2rlfB-4rnlA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rz9 PRE-MRNA-SPLICING
FACTOR 38A

(Homo sapiens) 		PF03371
(PRP38) 		4 LEU A 123
ASP A 126
ILE A 130
ARG A 128
 None
 0.99A 2rlfA-4rz9A:
undetectable
2rlfB-4rz9A:
undetectable		 2rlfA-4rz9A:
11.18
2rlfB-4rz9A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9v N-ALPHA-ACETYLTRANSF
ERASE 40

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		4 LEU B 173
LEU B 214
ILE B 156
ARG B 216
 ACO  B 301 ( 4.2A)
None
None
None
 1.01A 2rlfA-4u9vB:
undetectable
2rlfB-4u9vB:
undetectable		 2rlfA-4u9vB:
10.71
2rlfB-4u9vB:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 LEU A 526
LEU A 525
ILE A 530
ARG A 531
 None
 0.97A 2rlfA-4uwaA:
undetectable
2rlfB-4uwaA:
undetectable		 2rlfA-4uwaA:
2.65
2rlfB-4uwaA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4we6 HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU A  68
LEU A  71
ILE A  27
ARG A  69
 None
 1.02A 2rlfA-4we6A:
undetectable
2rlfB-4we6A:
undetectable		 2rlfA-4we6A:
10.37
2rlfB-4we6A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA

(Escherichia
virus T4;
Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		4 LEU A 293
LEU A 296
ASP A 297
TRP A 364
 None
 1.05A 2rlfA-4wtvA:
undetectable
2rlfB-4wtvA:
undetectable		 2rlfA-4wtvA:
6.49
2rlfB-4wtvA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xtk CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Thermotoga
maritima) 		PF01867
(Cas_Cas1) 		4 LEU A  54
LEU A  51
ILE A  19
ARG A  14
 None
 0.96A 2rlfA-4xtkA:
undetectable
2rlfB-4xtkA:
undetectable		 2rlfA-4xtkA:
10.19
2rlfB-4xtkA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Homo sapiens) 		PF04389
(Peptidase_M28) 		4 LEU A  73
LEU A  70
ILE A  91
ARG A  94
 None
 0.94A 2rlfA-4yu9A:
undetectable
2rlfB-4yu9A:
undetectable		 2rlfA-4yu9A:
9.88
2rlfB-4yu9A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zih APOPTOSIS REGULATOR
BAX

(Homo sapiens) 		PF00452
(Bcl-2) 		4 LEU A  63
LEU A  59
ILE A  66
ARG A  65
 None
 0.87A 2rlfA-4zihA:
undetectable
2rlfB-4zihA:
undetectable		 2rlfA-4zihA:
14.29
2rlfB-4zihA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		4 LEU C 269
LEU C 268
ASP C 390
ILE C 396
 None
 0.86A 2rlfA-5aa5C:
undetectable
2rlfB-5aa5C:
undetectable		 2rlfA-5aa5C:
6.54
2rlfB-5aa5C:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P

(Lachancea
thermotolerans) 		no annotation 4 LEU A 425
LEU A 429
TRP A 426
ILE A 460
 None
 1.03A 2rlfA-5f0oA:
undetectable
2rlfB-5f0oA:
undetectable		 2rlfA-5f0oA:
4.19
2rlfB-5f0oA:
4.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggy IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		4 LEU A 131
LEU A 127
ILE A 134
ARG A 133
 None
 0.94A 2rlfA-5ggyA:
undetectable
2rlfB-5ggyA:
undetectable		 2rlfA-5ggyA:
13.50
2rlfB-5ggyA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		4 LEU A 622
LEU A 621
ILE A 701
ARG A 702
 None
 0.95A 2rlfA-5gl7A:
undetectable
2rlfB-5gl7A:
undetectable		 2rlfA-5gl7A:
5.12
2rlfB-5gl7A:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmk PRE-MRNA-SPLICING
FACTOR CWC22

(Saccharomyces
cerevisiae) 		PF02847
(MA3) 		4 LEU Z  83
LEU Z  82
ASP Z  86
ILE Z  49
 None
 1.05A 2rlfA-5gmkZ:
undetectable
2rlfB-5gmkZ:
undetectable		 2rlfA-5gmkZ:
6.96
2rlfB-5gmkZ:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 4 LEU A 409
LEU A 406
ASP A 405
ILE A 459
 None
 1.02A 2rlfA-5h7jA:
undetectable
2rlfB-5h7jA:
undetectable		 2rlfA-5h7jA:
17.57
2rlfB-5h7jA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7

(Saccharomyces
cerevisiae) 		PF00160
(Pro_isomerase)
PF00515
(TPR_1) 		4 LEU A 350
LEU A 346
ILE A 370
ARG A 369
 None
 0.97A 2rlfA-5jheA:
undetectable
2rlfB-5jheA:
undetectable		 2rlfA-5jheA:
8.67
2rlfB-5jheA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnz ALPHA CHAIN

(Acipenser
stellatus) 		PF00042
(Globin) 		4 LEU A 110
LEU A 107
ILE A  24
ARG A  31
 None
 1.04A 2rlfA-5jnzA:
undetectable
2rlfB-5jnzA:
undetectable		 2rlfA-5jnzA:
17.97
2rlfB-5jnzA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6w PROTEIN SIDEKICK-1

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 LEU A 440
LEU A 435
ILE A 442
ARG A 441
 None
 1.00A 2rlfA-5k6wA:
undetectable
2rlfB-5k6wA:
undetectable		 2rlfA-5k6wA:
7.57
2rlfB-5k6wA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 4 LEU B 432
LEU B 431
ILE B 379
ARG B 376
 None
 1.04A 2rlfA-5ltmB:
undetectable
2rlfB-5ltmB:
undetectable		 2rlfA-5ltmB:
6.21
2rlfB-5ltmB:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my3 RHO
GTPASE-ACTIVATING
PROTEIN RGD1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 154
LEU A 157
ILE A 143
ARG A 155
 None
 0.93A 2rlfA-5my3A:
undetectable
2rlfB-5my3A:
undetectable		 2rlfA-5my3A:
22.22
2rlfB-5my3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE PMBA

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		4 LEU B 328
LEU B 329
ILE B 318
ARG B 316
 None
 1.04A 2rlfA-5njfB:
undetectable
2rlfB-5njfB:
undetectable		 2rlfA-5njfB:
8.55
2rlfB-5njfB:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4

(Homo sapiens) 		no annotation 4 LEU A 474
LEU A 458
ILE A 453
ARG A 449
 None
 1.03A 2rlfA-5nqaA:
undetectable
2rlfB-5nqaA:
undetectable		 2rlfA-5nqaA:
22.08
2rlfB-5nqaA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		PF04095
(NAPRTase) 		4 LEU A 325
LEU A 328
ILE A 378
ARG A 349
 None
 1.04A 2rlfA-5u2nA:
undetectable
2rlfB-5u2nA:
undetectable		 2rlfA-5u2nA:
7.25
2rlfB-5u2nA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umn HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU A 108
LEU A 111
ILE A  67
ARG A 109
 None
 1.05A 2rlfA-5umnA:
undetectable
2rlfB-5umnA:
undetectable		 2rlfA-5umnA:
11.45
2rlfB-5umnA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1
CRISPR-ASSOCIATED
PROTEIN CSY2

(Pseudomonas
aeruginosa) 		PF09611
(Cas_Csy1)
PF09614
(Cas_Csy2) 		4 LEU A 264
LEU A 265
TRP B  29
ILE B  23
 None
 1.06A 2rlfA-5uz9A:
undetectable
2rlfB-5uz9A:
undetectable		 2rlfA-5uz9A:
9.43
2rlfB-5uz9A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA

(Escherichia
virus T4;
Mycobacterium
kansasii) 		PF00959
(Phage_lysozyme)
PF14011
(ESX-1_EspG) 		4 LEU A 263
LEU A 260
ILE A 236
ARG A 235
 CL  A1205 ( 4.4A)
None
None
None
 0.98A 2rlfA-5vbaA:
undetectable
2rlfB-5vbaA:
undetectable		 2rlfA-5vbaA:
6.33
2rlfB-5vbaA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsl KERATINASE

(Meiothermus
taiwanensis) 		no annotation 4 LEU A 199
LEU A 197
ILE A 253
ARG A 250
 None
 1.02A 2rlfA-5wslA:
undetectable
2rlfB-5wslA:
undetectable		 2rlfA-5wslA:
8.33
2rlfB-5wslA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x41 COBALT ABC
TRANSPORTER
ATP-BINDING PROTEIN

(Rhodobacter
capsulatus) 		PF00005
(ABC_tran) 		4 LEU A 183
LEU A 180
ILE A 151
ARG A 148
 None
 0.75A 2rlfA-5x41A:
undetectable
2rlfB-5x41A:
undetectable		 2rlfA-5x41A:
10.19
2rlfB-5x41A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1

(Homo sapiens) 		PF00514
(Arm) 		4 LEU A 424
LEU A 421
ILE A 381
ARG A 378
 None
 1.03A 2rlfA-5xgcA:
undetectable
2rlfB-5xgcA:
undetectable		 2rlfA-5xgcA:
6.70
2rlfB-5xgcA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta) 		no annotation 4 LEU A 330
LEU A 328
ILE A 334
ARG A 332
 None
 0.79A 2rlfA-6bk5A:
undetectable
2rlfB-6bk5A:
undetectable		 2rlfA-6bk5A:
20.78
2rlfB-6bk5A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY

(Thermobifida
fusca) 		no annotation 4 LEU M 200
ASP M 202
ILE M 219
ARG M  32
 None
 1.00A 2rlfA-6c66M:
undetectable
2rlfB-6c66M:
undetectable		 2rlfA-6c66M:
19.28
2rlfB-6c66M:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo sapiens) 		no annotation 4 LEU A 228
LEU A 225
ILE A 196
ARG A 193
 None
 0.83A 2rlfA-6etiA:
undetectable
2rlfB-6etiA:
undetectable		 2rlfA-6etiA:
20.51
2rlfB-6etiA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1t CYTOPLASMIC DYNEIN 1
HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,DYNEIN HEAVY
CHAIN,CYTOPLASMIC
DYNEIN 1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,DYNEIN HEAVY
CHAIN,CYTOPLASMIC
DYNEIN 1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN 1

(Homo sapiens) 		no annotation 4 LEU e 285
LEU e 281
ILE e 288
ARG e 287
 None
 0.96A 2rlfA-6f1te:
undetectable
2rlfB-6f1te:
undetectable		 2rlfA-6f1te:
24.05
2rlfB-6f1te:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza B
virus) 		no annotation 4 LEU B  89
LEU B  92
ASP B  93
ILE A 233
 None
 1.07A 2rlfA-6f5oB:
undetectable
2rlfB-6f5oB:
undetectable		 2rlfA-6f5oB:
13.51
2rlfB-6f5oB:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 4 LEU A 674
LEU A 676
ILE A 684
ARG A 683
 None
 1.02A 2rlfA-6f8zA:
undetectable
2rlfB-6f8zA:
undetectable		 2rlfA-6f8zA:
17.95
2rlfB-6f8zA:
17.95