SIMILAR PATTERNS OF AMINO ACIDS FOR 2RLC_A_GLYA333_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ak0 P1 NUCLEASE

(Penicillium
citrinum) 		PF02265
(S1-P1_nuclease) 		3 ASN A  71
ASN A  73
ARG A  78
 None
 0.95A 2rlcA-1ak0A:
undetectable		 2rlcA-1ak0A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyg CYCLODEXTRIN
GLUCANOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		3 ASN A 200
ASN A 197
ARG A 583
 None
 0.93A 2rlcA-1cygA:
undetectable		 2rlcA-1cygA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 ASN A 935
ASN A 544
ARG A 909
 None
 0.91A 2rlcA-1f4hA:
0.0		 2rlcA-1f4hA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 276
ASN A 305
ARG A 497
 None
 0.86A 2rlcA-1fprA:
undetectable		 2rlcA-1fprA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 ASN A 420
ASN A 311
ARG A 240
 None
 0.74A 2rlcA-1j6uA:
0.0		 2rlcA-1j6uA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 ASN A 109
ASN A  89
ARG A  55
 None
 0.89A 2rlcA-1jx2A:
0.0		 2rlcA-1jx2A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A  46
ASN A  70
ARG A 255
 None
 0.74A 2rlcA-1l8kA:
0.0		 2rlcA-1l8kA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A1353
ASN A1381
ARG A1561
 None
 0.73A 2rlcA-1larA:
0.0		 2rlcA-1larA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A1642
ASN A1670
ARG A1852
 None
 0.72A 2rlcA-1larA:
0.0		 2rlcA-1larA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 ASN A 125
ASN A 122
ARG A  15
 None
 0.89A 2rlcA-1lnlA:
undetectable		 2rlcA-1lnlA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		3 ASN A 554
ASN A 582
ARG A 763
 None
 0.65A 2rlcA-1p15A:
undetectable		 2rlcA-1p15A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pto PERTUSSIS TOXIN

(Bordetella
pertussis) 		PF02918
(Pertussis_S2S3)
PF03440
(APT) 		3 ASN B 116
ASN B  25
ARG B  22
 None
 0.80A 2rlcA-1ptoB:
undetectable		 2rlcA-1ptoB:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 927
ASN A 955
ARG A1134
 None
 0.78A 2rlcA-1rpmA:
undetectable		 2rlcA-1rpmA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ

(Glycine max) 		PF00190
(Cupin_1) 		3 ASN A 420
ASN A 477
ARG A 363
 None
 0.89A 2rlcA-1uikA:
undetectable		 2rlcA-1uikA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ASN A  54
ASN A  19
ARG A  76
 None
 0.93A 2rlcA-1w9xA:
undetectable		 2rlcA-1w9xA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A2241
ASN A2264
ARG A2447
 None
 0.68A 2rlcA-1wchA:
undetectable		 2rlcA-1wchA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdp POLYPHOSPHATE KINASE

(Escherichia
coli) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		3 ASN A 538
ASN A 539
ARG A  53
 ATP  A 701 ( 4.7A)
None
None
 0.94A 2rlcA-1xdpA:
undetectable		 2rlcA-1xdpA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		3 ASN A 260
ASN A 288
ARG A 472
 None
 0.65A 2rlcA-1yfoA:
undetectable		 2rlcA-1yfoA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 656
ASN A 684
ARG A 867
 None
 0.66A 2rlcA-1yguA:
undetectable		 2rlcA-1yguA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 947
ASN A 994
ARG A1183
 None
 0.77A 2rlcA-1yguA:
undetectable		 2rlcA-1yguA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE

(Yersinia
enterocolitica) 		PF00102
(Y_phosphatase) 		3 ASN A 227
ASN A 245
ARG A 440
 None
 0.66A 2rlcA-1ytsA:
undetectable		 2rlcA-1ytsA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbs HYPOTHETICAL PROTEIN
PG1100

(Porphyromonas
gingivalis) 		PF01869
(BcrAD_BadFG) 		3 ASN A 280
ASN A 281
ARG A 128
 None
 0.87A 2rlcA-1zbsA:
undetectable		 2rlcA-1zbsA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl6 BOTULINUM NEUROTOXIN
TYPE E

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 ASN A 364
ASN A 361
ARG A  81
 None
 0.89A 2rlcA-1zl6A:
undetectable		 2rlcA-1zl6A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 419
ASN A 448
ARG A 627
 None
 0.78A 2rlcA-2a8bA:
undetectable		 2rlcA-2a8bA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		3 ASN A 274
ASN A 303
ARG A 495
 None
 0.85A 2rlcA-2b3oA:
undetectable		 2rlcA-2b3oA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 674
ASN A 697
ARG A 881
 None
 0.67A 2rlcA-2b49A:
undetectable		 2rlcA-2b49A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 302
ASN A 331
ARG A 511
 None
 0.82A 2rlcA-2bv5A:
undetectable		 2rlcA-2bv5A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 915
ASN A 943
ARG A1122
 None
 0.77A 2rlcA-2c7sA:
undetectable		 2rlcA-2c7sA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfv HUMAN PROTEIN
TYROSINE PHOSPHATASE
RECEPTOR TYPE J

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A1069
ASN A1096
ARG A1278
 None
 0.70A 2rlcA-2cfvA:
undetectable		 2rlcA-2cfvA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ASN A  54
ASN A  19
ARG A  76
 None
 0.91A 2rlcA-2d3lA:
undetectable		 2rlcA-2d3lA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 966
ASN A 994
ARG A1175
 None
 0.68A 2rlcA-2gjtA:
undetectable		 2rlcA-2gjtA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A1731
ASN A1759
ARG A1943
 None
 0.65A 2rlcA-2h03A:
undetectable		 2rlcA-2h03A:
19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hf0 BILE SALT HYDROLASE

(Bifidobacterium
longum) 		PF02275
(CBAH) 		3 ASN A  81
ASN A 172
ARG A 225
 None
 0.39A 2rlcA-2hf0A:
40.4		 2rlcA-2hf0A:
35.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 738
ASN A 766
ARG A 949
 None
 0.60A 2rlcA-2i1yA:
undetectable		 2rlcA-2i1yA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i75 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 4

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 683
ASN A 706
ARG A 891
 None
 0.71A 2rlcA-2i75A:
undetectable		 2rlcA-2i75A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 163
ASN A 191
ARG A 374
 None
 0.67A 2rlcA-2jjdA:
undetectable		 2rlcA-2jjdA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 878
ASN A 908
ARG A1099
 None
 0.76A 2rlcA-2nlkA:
undetectable		 2rlcA-2nlkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A1179
ASN A1207
ARG A1390
 None
 0.83A 2rlcA-2nlkA:
undetectable		 2rlcA-2nlkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv5 PTPRD, PHOSPHATASE

(Rattus
norvegicus) 		PF00102
(Y_phosphatase) 		3 ASN A1255
ASN A1283
ARG A1463
 None
 0.69A 2rlcA-2nv5A:
undetectable		 2rlcA-2nv5A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 938
ASN A 966
ARG A1145
 None
 0.75A 2rlcA-2ooqA:
undetectable		 2rlcA-2ooqA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 331
ASN A 359
ARG A 554
 None
 0.79A 2rlcA-2pa5A:
undetectable		 2rlcA-2pa5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 774
ASN A 802
ARG A 985
 None
 0.72A 2rlcA-2qepA:
undetectable		 2rlcA-2qepA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgs PROTEIN SE1688

(Staphylococcus
epidermidis) 		no annotation 3 ASN A  35
ASN A  36
ARG A 197
 None
 0.96A 2rlcA-2qgsA:
undetectable		 2rlcA-2qgsA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtv SMALL COPII COAT
GTPASE SAR1
PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00025
(Arf)
PF11549
(Sec31) 		3 ASN D 915
ASN D 919
ARG B  82
 None
 0.94A 2rlcA-2qtvD:
undetectable		 2rlcA-2qtvD:
10.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rg2 CHOLOYLGLYCINE
HYDROLASE

(Clostridium
perfringens) 		PF02275
(CBAH) 		3 ASN A  82
ASN A 175
ARG A 228
 GOL  A 336 (-3.7A)
CSO  A   2 (-3.1A)
CSO  A   2 ( 3.4A)
 0.13A 2rlcA-2rg2A:
53.5		 2rlcA-2rg2A:
99.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		3 ASN A  79
ASN A  88
ARG A 115
 NAG  A 601 ( 1.8A)
NAG  A 601 ( 4.1A)
None
 0.84A 2rlcA-2rmpA:
undetectable		 2rlcA-2rmpA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		3 ASN A 293
ASN A 271
ARG A 502
 BGC  A1526 (-3.0A)
None
None
 0.72A 2rlcA-2wzfA:
undetectable		 2rlcA-2wzfA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zah COAT PROTEIN

(Melon necrotic
spot virus) 		PF00729
(Viral_coat) 		3 ASN A 132
ASN A 286
ARG A 126
 None
 0.94A 2rlcA-2zahA:
undetectable		 2rlcA-2zahA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ASN A 352
ASN A 355
ARG A 334
 None
 0.70A 2rlcA-2zu6A:
undetectable		 2rlcA-2zu6A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A  44
ASN A  68
ARG A 257
 None
 0.71A 2rlcA-3a5kA:
undetectable		 2rlcA-3a5kA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqm CELL INHIBITING
FACTOR (CIFBP)

(Burkholderia
pseudomallei) 		PF16374
(CIF) 		3 ASN A  95
ASN A  96
ARG A  51
 None
 0.82A 2rlcA-3gqmA:
undetectable		 2rlcA-3gqmA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A  58
ASN A  86
ARG A 269
 None
 0.74A 2rlcA-3h2xA:
undetectable		 2rlcA-3h2xA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1

(Rattus
norvegicus) 		PF00102
(Y_phosphatase) 		3 ASN A 948
ASN A 975
ARG A1157
 None
 0.72A 2rlcA-3i36A:
undetectable		 2rlcA-3i36A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kar KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		3 ASN A 486
ASN A 448
ARG A 392
 None
None
ADP  A 999 (-2.8A)
 0.81A 2rlcA-3karA:
undetectable		 2rlcA-3karA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00102
(Y_phosphatase) 		3 ASN A  49
ASN A  80
ARG A 270
 None
 0.92A 2rlcA-3m4uA:
undetectable		 2rlcA-3m4uA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkq COATOMER
BETA'-SUBUNIT

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		3 ASN A 421
ASN A 405
ARG A 369
 None
 0.86A 2rlcA-3mkqA:
undetectable		 2rlcA-3mkqA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		3 ASN A 412
ASN A 407
ARG A 398
 None
 0.80A 2rlcA-3nvaA:
undetectable		 2rlcA-3nvaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		3 ASN A 274
ASN A 303
ARG A 495
 None
 0.75A 2rlcA-3ps5A:
undetectable		 2rlcA-3ps5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 878
ASN A 908
ARG A1099
 None
 0.76A 2rlcA-3qciA:
undetectable		 2rlcA-3qciA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlb ENANTIO-PYOCHELIN
RECEPTOR

(Pseudomonas
fluorescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ASN A 310
ASN A 275
ARG A  91
 None
None
EFE  A 701 (-4.0A)
 0.92A 2rlcA-3qlbA:
undetectable		 2rlcA-3qlbA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D

(Drosophila
melanogaster) 		PF00102
(Y_phosphatase) 		3 ASN A  74
ASN A 102
ARG A 281
 None
 0.71A 2rlcA-3s3fA:
undetectable		 2rlcA-3s3fA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0q AGR253WP

(Eremothecium
gossypii) 		PF00225
(Kinesin) 		3 ASN A 465
ASN A 427
ARG A 372
 None
None
ADP  A 999 (-3.2A)
 0.67A 2rlcA-3t0qA:
undetectable		 2rlcA-3t0qA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqc MYB3

(Trichomonas
vaginalis) 		PF00249
(Myb_DNA-binding) 		3 ASN A 140
ASN A  97
ARG A  92
 None
 0.91A 2rlcA-3zqcA:
undetectable		 2rlcA-3zqcA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4abn TETRATRICOPEPTIDE
REPEAT PROTEIN 5

(Mus musculus) 		PF16669
(TTC5_OB) 		3 ASN A 107
ASN A 141
ARG A 180
 None
 0.65A 2rlcA-4abnA:
undetectable		 2rlcA-4abnA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ASN A 365
ASN A 383
ARG A 462
 None
 0.68A 2rlcA-4aipA:
undetectable		 2rlcA-4aipA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE

(Trypanosoma
cruzi) 		PF00102
(Y_phosphatase) 		3 ASN A  49
ASN A  78
ARG A 267
 None
 0.88A 2rlcA-4az1A:
undetectable		 2rlcA-4az1A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A1420
ASN A1448
ARG A1628
 None
 0.73A 2rlcA-4bpcA:
undetectable		 2rlcA-4bpcA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A1709
ASN A1737
ARG A1919
 None
 0.69A 2rlcA-4bpcA:
undetectable		 2rlcA-4bpcA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgt CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		3 ASN A 204
ASN A 201
ARG A 588
 None
 0.94A 2rlcA-4cgtA:
undetectable		 2rlcA-4cgtA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etp KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		3 ASN A 486
ASN A 448
ARG A 392
 None
None
ADP  A 801 (-3.4A)
 0.65A 2rlcA-4etpA:
undetectable		 2rlcA-4etpA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		3 ASN A 605
ASN A 604
ARG A 479
 None
 0.81A 2rlcA-4fnvA:
undetectable		 2rlcA-4fnvA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 3 ASN A 623
ASN A 725
ARG A 682
 None
 0.75A 2rlcA-4fyeA:
undetectable		 2rlcA-4fyeA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkr NECK AND C-TERMINAL
MOTOR DOMAIN OF KAR3

([Candida]
glabrata) 		PF00225
(Kinesin) 		3 ASN A 447
ASN A 409
ARG A 356
 None
None
ADP  A 702 (-3.3A)
 0.69A 2rlcA-4gkrA:
undetectable		 2rlcA-4gkrA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1i MALATE DEHYDROGENASE

(Leishmania
major) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ASN A 133
ASN A 186
ARG A  97
 None
 0.94A 2rlcA-4i1iA:
undetectable		 2rlcA-4i1iA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikc PHOSPHOTIDYLINOSITOL
PHOSPHATASE PTPRQ

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A2710
ASN A2738
ARG A2918
 None
 0.68A 2rlcA-4ikcA:
undetectable		 2rlcA-4ikcA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnd TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 18

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A  60
ASN A  88
ARG A 271
 None
 0.72A 2rlcA-4nndA:
undetectable		 2rlcA-4nndA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		3 ASN A 155
ASN A 456
ARG A1125
 None
 0.79A 2rlcA-4pj3A:
undetectable		 2rlcA-4pj3A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 277
ASN A 306
ARG A 501
 None
 0.76A 2rlcA-4pvgA:
undetectable		 2rlcA-4pvgA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg8 EXONUCLEASE I

(Methylocaldum
szegediense) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		3 ASN A 253
ASN A 301
ARG A 109
 None
 0.76A 2rlcA-4rg8A:
undetectable		 2rlcA-4rg8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin) 		3 ASN G  54
ASN G  56
ARG G  91
 None
 0.91A 2rlcA-4z94G:
undetectable		 2rlcA-4z94G:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxc HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT

(Pseudomonas sp.
WBC-3) 		no annotation 3 ASN W 158
ASN W 138
ARG W  41
 None
 0.91A 2rlcA-4zxcW:
undetectable		 2rlcA-4zxcW:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ASN A  71
ASN A 566
ARG A 354
 None
 0.81A 2rlcA-5ck0A:
undetectable		 2rlcA-5ck0A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		3 ASN A 222
ASN A 177
ARG A  55
 None
None
EDO  A 602 (-4.7A)
 0.92A 2rlcA-5ecuA:
undetectable		 2rlcA-5ecuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 ASN A 226
ASN A 240
ARG A 211
 None
 0.90A 2rlcA-5f7cA:
undetectable		 2rlcA-5f7cA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g56 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase)
PF03422
(CBM_6) 		3 ASN A 543
ASN A 544
ARG A 576
 None
 0.78A 2rlcA-5g56A:
undetectable		 2rlcA-5g56A:
17.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gs7 CHOLOYLGLYCINE
HYDROLASE

(Enterococcus
faecalis) 		PF02275
(CBAH) 		3 ASN A  79
ASN A 170
ARG A 223
 None
 0.15A 2rlcA-5gs7A:
43.4		 2rlcA-5gs7A:
43.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A1754
ASN A1784
ARG A1972
 None
 0.80A 2rlcA-5h08A:
undetectable		 2rlcA-5h08A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hde TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 12

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A  62
ASN A  90
ARG A 273
 None
 0.70A 2rlcA-5hdeA:
undetectable		 2rlcA-5hdeA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		3 ASN A  79
ASN A 171
ARG A 224
 OCS  A   2 ( 3.7A)
OCS  A   2 ( 3.2A)
OCS  A   2 ( 3.3A)
 0.77A 2rlcA-5hkeA:
42.3		 2rlcA-5hkeA:
36.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5d INNER MEMBRANE
PROTEIN YEJM

(Salmonella
enterica) 		PF00884
(Sulfatase)
PF11893
(DUF3413) 		3 ASN A 400
ASN A 403
ARG A 451
 None
 0.91A 2rlcA-5i5dA:
undetectable		 2rlcA-5i5dA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5h INNER MEMBRANE
PROTEIN YEJM

(Escherichia
coli) 		PF00884
(Sulfatase)
PF11893
(DUF3413) 		3 ASN A 400
ASN A 403
ARG A 451
 None
 0.79A 2rlcA-5i5hA:
undetectable		 2rlcA-5i5hA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		3 ASN A 277
ASN A 306
ARG A 501
 None
 0.68A 2rlcA-5i6vA:
undetectable		 2rlcA-5i6vA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE

(Hypericum
androsaemum) 		no annotation 3 ASN A 183
ASN A 184
ARG A 158
 None
 0.81A 2rlcA-5ucoA:
undetectable		 2rlcA-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyb -

(-) 		no annotation 3 ASN A 279
ASN A 307
ARG A 340
 None
 0.70A 2rlcA-5xybA:
undetectable		 2rlcA-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF

(Caldanaerobacter
subterraneus) 		no annotation 3 ASN A  13
ASN A  38
ARG A  53
 None
 0.88A 2rlcA-5z67A:
undetectable		 2rlcA-5z67A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co0 STYRYLPYRONE
SYNTHASE 1

(Piper
methysticum) 		no annotation 3 ASN A 180
ASN A 181
ARG A 155
 None
 0.95A 2rlcA-6co0A:
undetectable		 2rlcA-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 3 ASN X 289
ASN X 255
ARG X 389
 None
 0.92A 2rlcA-6elqX:
undetectable		 2rlcA-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1

(Saccharomyces
cerevisiae) 		no annotation 3 ASN A 539
ASN A 540
ARG A 482
 None
 0.90A 2rlcA-6f42A:
undetectable		 2rlcA-6f42A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 3 ASN A2257
ASN A2484
ARG A2464
 None
 0.89A 2rlcA-6fb3A:
undetectable		 2rlcA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fjy PROTEIN CSUE

(Acinetobacter
baumannii) 		no annotation 3 ASN D 221
ASN D 222
ARG D 255
 None
 0.61A 2rlcA-6fjyD:
undetectable		 2rlcA-6fjyD:
undetectable