SIMILAR PATTERNS OF AMINO ACIDS FOR 2RLC_A_CHDA332_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aha | ALPHA-MOMORCHARIN (Momordicacharantia) |
PF00161(RIP) | 5 | ILE A 60THR A 157ASN A 54ILE A 127LEU A 6 | None | 1.16A | 2rlcA-1ahaA:0.0 | 2rlcA-1ahaA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ati | GLYCYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon) | 5 | ARG A 260PHE A 230ALA A 362ILE A 229LEU A 45 | None | 1.09A | 2rlcA-1atiA:0.0 | 2rlcA-1atiA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ggp | PROTEIN (LECTIN 1 ACHAIN) (Trichosantheskirilowii) |
PF00161(RIP) | 5 | THR A 236ALA A 238ILE A 227ILE A 228LEU A 201 | None | 1.02A | 2rlcA-1ggpA:0.0 | 2rlcA-1ggpA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lam | LEUCINEAMINOPEPTIDASE (Bos taurus) |
PF00883(Peptidase_M17)PF02789(Peptidase_M17_N) | 5 | ILE A 338THR A 361ALA A 358ILE A 421LEU A 436 | None | 1.04A | 2rlcA-1lamA:0.0 | 2rlcA-1lamA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nr3 | DNA-BINDING PROTEINTFX (Methanothermobacterthermautotrophicus) |
PF14601(TFX_C) | 5 | ALA A 24ILE A 79ILE A 11THR A 84LEU A 88 | None | 1.17A | 2rlcA-1nr3A:0.0 | 2rlcA-1nr3A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sq7 | TRIOSEPHOSPHATEISOMERASE (Gallus gallus) |
PF00121(TIM) | 5 | ILE A 243PHE A 229ALA A 221ASN A 245THR A 37 | None | 0.85A | 2rlcA-1sq7A:0.0 | 2rlcA-1sq7A:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t1e | KUMAMOLISIN (Bacillus sp.MN-32) |
PF00082(Peptidase_S8)PF09286(Pro-kuma_activ) | 5 | ILE A 413PHE A 296ALA A 331ILE A 300ILE A 316 | None | 1.05A | 2rlcA-1t1eA:0.0 | 2rlcA-1t1eA:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t71 | PHOSPHATASE (Mycoplasmapneumoniae) |
PF13277(YmdB) | 5 | ILE A 145PHE A 172ASN A 122THR A 121LEU A 93 | None | 1.10A | 2rlcA-1t71A:0.0 | 2rlcA-1t71A:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tr1 | BETA-GLUCOSIDASE A (Paenibacilluspolymyxa) |
PF00232(Glyco_hydro_1) | 5 | ILE A 170PHE A 164ALA A 200ILE A 288ILE A 291 | None | 1.16A | 2rlcA-1tr1A:undetectable | 2rlcA-1tr1A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wa5 | IMPORTIN ALPHASUBUNIT (Saccharomycescerevisiae) |
PF00514(Arm)PF01749(IBB)PF16186(Arm_3) | 5 | ILE B 430ALA B 451ASN B 473ILE B 376ILE B 380 | None | 1.18A | 2rlcA-1wa5B:undetectable | 2rlcA-1wa5B:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x9n | DNA LIGASE I (Homo sapiens) |
PF01068(DNA_ligase_A_M)PF04675(DNA_ligase_A_N)PF04679(DNA_ligase_A_C) | 5 | THR A 620ALA A 696ILE A 576ILE A 605LEU A 682 | None | 1.14A | 2rlcA-1x9nA:undetectable | 2rlcA-1x9nA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yj8 | GLYCEROL-3-PHOSPHATEDEHYDROGENASE (Plasmodiumfalciparum) |
PF01210(NAD_Gly3P_dh_N)PF07479(NAD_Gly3P_dh_C) | 5 | PHE A 203ALA A 179ASN A 78ILE A 108LEU A 87 | None | 1.06A | 2rlcA-1yj8A:undetectable | 2rlcA-1yj8A:24.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bkw | ALANINE-GLYOXYLATEAMINOTRANSFERASE 1 (Saccharomycescerevisiae) |
PF00266(Aminotran_5) | 5 | PHE A 185THR A 197ALA A 195ILE A 203ILE A 274 | None | 0.89A | 2rlcA-2bkwA:undetectable | 2rlcA-2bkwA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bmx | ALKYLHYDROPEROXIDASE C (Mycobacteriumtuberculosis) |
PF00578(AhpC-TSA) | 6 | ILE A 144PHE A 136PHE A 51ALA A 122ASN A 142ILE A 82 | None | 1.37A | 2rlcA-2bmxA:undetectable | 2rlcA-2bmxA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c3o | PYRUVATE-FERREDOXINOXIDOREDUCTASE (Desulfovibrioafricanus) |
PF01558(POR)PF01855(POR_N)PF02775(TPP_enzyme_C)PF10371(EKR)PF13484(Fer4_16)PF17147(PFOR_II) | 5 | PHE A 470ALA A 566ASN A 560ILE A 441ILE A 438 | None | 1.17A | 2rlcA-2c3oA:undetectable | 2rlcA-2c3oA:13.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cwl | MANGANESE-FREEPSEUDOCATALASE (Thermusthermophilus) |
PF05067(Mn_catalase) | 5 | ILE A 178ALA A 25ASN A 82THR A 80LEU A 84 | None | 1.07A | 2rlcA-2cwlA:undetectable | 2rlcA-2cwlA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2esr | METHYLTRANSFERASE (Streptococcuspyogenes) |
PF03602(Cons_hypoth95) | 5 | ILE A 32PHE A 115ALA A 59ILE A 80ASN A 83 | None | 1.16A | 2rlcA-2esrA:undetectable | 2rlcA-2esrA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fct | SYRINGOMYCINBIOSYNTHESIS ENZYME2 (Pseudomonassyringae) |
PF05721(PhyH) | 5 | PHE A 24ALA A 147ILE A 228ILE A 21LEU A 158 | None | 1.16A | 2rlcA-2fctA:undetectable | 2rlcA-2fctA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ggq | 401AA LONGHYPOTHETICALGLUCOSE-1-PHOSPHATETHYMIDYLYLTRANSFERASE (Sulfurisphaeratokodaii) |
PF00132(Hexapep)PF00483(NTP_transferase) | 5 | ILE A 167PHE A 168ALA A 87ILE A 77LEU A 6 | NoneNoneNoneNoneTTP A 500 (-4.0A) | 1.07A | 2rlcA-2ggqA:undetectable | 2rlcA-2ggqA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9e | TRIOSEPHOSPHATEISOMERASE (Tenebriomolitor) |
PF00121(TIM) | 5 | ILE A 242PHE A 228ALA A 220ASN A 244THR A 36 | None | 0.90A | 2rlcA-2i9eA:undetectable | 2rlcA-2i9eA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ib5 | CHROMO PROTEIN (Epiactisjaponica) |
PF01353(GFP) | 5 | PHE A 211THR A 59ILE A 201THR A 137LEU A 162 | None | 0.97A | 2rlcA-2ib5A:undetectable | 2rlcA-2ib5A:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j7n | RNA-DEPENDENT RNAPOLYMERASE (Neurosporacrassa) |
PF05183(RdRP) | 5 | ILE A 565ALA A1076ILE A 608ILE A 607THR A 544 | None | 1.10A | 2rlcA-2j7nA:undetectable | 2rlcA-2j7nA:14.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2je1 | ACIDIC LEUCINE-RICHNUCLEARPHOSPHOPROTEIN 32FAMILY MEMBER A (Homo sapiens) |
PF14580(LRR_9) | 5 | ILE A 57PHE A 41ASN A 74ILE A 7THR A 49 | None | 1.14A | 2rlcA-2je1A:undetectable | 2rlcA-2je1A:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jqd | ACIDIC LEUCINE-RICHNUCLEARPHOSPHOPROTEIN 32FAMILY MEMBER A (Mus musculus) |
PF14580(LRR_9) | 5 | ILE A 57PHE A 41ASN A 74ILE A 7THR A 49 | None | 1.09A | 2rlcA-2jqdA:undetectable | 2rlcA-2jqdA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l10 | TALIN-1 (Mus musculus) |
PF08913(VBS) | 5 | PHE A1281ALA A1215ILE A1308ILE A1346LEU A1316 | None | 1.04A | 2rlcA-2l10A:undetectable | 2rlcA-2l10A:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ph0 | UNCHARACTERIZEDPROTEIN (Pectobacteriumcarotovorum) |
PF06228(ChuX_HutX) | 5 | ILE A 64PHE A 137PHE A 110ILE A 108LEU A 28 | None | 1.00A | 2rlcA-2ph0A:undetectable | 2rlcA-2ph0A:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2psf | RENILLA-LUCIFERIN2-MONOOXYGENASE (Renillareniformis) |
PF00561(Abhydrolase_1) | 5 | ARG A 136ILE A 137PHE A 116PHE A 49ILE A 67 | None | 1.14A | 2rlcA-2psfA:undetectable | 2rlcA-2psfA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q07 | UNCHARACTERIZEDPROTEIN AF0587 (Archaeoglobusfulgidus) |
PF01472(PUA) | 5 | PHE A 499ALA A 452ASN A 458ILE A 520THR A 461 | None | 1.12A | 2rlcA-2q07A:undetectable | 2rlcA-2q07A:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qmi | PBP RELATEDBETA-LACTAMASE (Pyrococcusabyssi) |
PF00144(Beta-lactamase)PF13969(Pab87_oct) | 5 | PHE A 142PHE A 120ILE A 231ASN A 162THR A 163 | None | 1.15A | 2rlcA-2qmiA:undetectable | 2rlcA-2qmiA:22.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rg2 | CHOLOYLGLYCINEHYDROLASE (Clostridiumperfringens) |
PF02275(CBAH) | 7 | ILE A 22PHE A 26ALA A 68ASN A 82ILE A 137THR A 140LEU A 142 | NoneEDO A 334 (-4.2A)EDO A 333 ( 3.7A)GOL A 336 (-3.7A)NoneNoneEDO A 333 ( 4.5A) | 1.05A | 2rlcA-2rg2A:53.5 | 2rlcA-2rg2A:99.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rg2 | CHOLOYLGLYCINEHYDROLASE (Clostridiumperfringens) |
PF02275(CBAH) | 9 | ILE A 22PHE A 26THR A 66ALA A 68ASN A 82ILE A 133ASN A 139THR A 140LEU A 142 | NoneEDO A 334 (-4.2A)EDO A 334 (-3.4A)EDO A 333 ( 3.7A)GOL A 336 (-3.7A)NoneNoneNoneEDO A 333 ( 4.5A) | 0.45A | 2rlcA-2rg2A:53.5 | 2rlcA-2rg2A:99.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rg2 | CHOLOYLGLYCINEHYDROLASE (Clostridiumperfringens) |
PF02275(CBAH) | 8 | ILE A 22THR A 66ASN A 82ILE A 133ILE A 137ASN A 139THR A 140LEU A 142 | NoneEDO A 334 (-3.4A)GOL A 336 (-3.7A)NoneNoneNoneNoneEDO A 333 ( 4.5A) | 0.84A | 2rlcA-2rg2A:53.5 | 2rlcA-2rg2A:99.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rg2 | CHOLOYLGLYCINEHYDROLASE (Clostridiumperfringens) |
PF02275(CBAH) | 6 | PHE A 61ASN A 82ILE A 133ILE A 137ASN A 139THR A 140 | NoneGOL A 336 (-3.7A)NoneNoneNoneNone | 0.96A | 2rlcA-2rg2A:53.5 | 2rlcA-2rg2A:99.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v8n | LACTOSE PERMEASE (Escherichiacoli) |
PF01306(LacY_symp) | 5 | ILE A 52PHE A 27PHE A 29ILE A 32ILE A 37 | None | 1.15A | 2rlcA-2v8nA:undetectable | 2rlcA-2v8nA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vca | ALPHA-N-ACETYLGLUCOSAMINIDASE (Clostridiumperfringens) |
PF00754(F5_F8_type_C)PF05089(NAGLU)PF12971(NAGLU_N)PF12972(NAGLU_C) | 5 | ILE A 124ALA A 96ILE A 67ILE A 147LEU A 71 | None | 1.06A | 2rlcA-2vcaA:undetectable | 2rlcA-2vcaA:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vca | ALPHA-N-ACETYLGLUCOSAMINIDASE (Clostridiumperfringens) |
PF00754(F5_F8_type_C)PF05089(NAGLU)PF12971(NAGLU_N)PF12972(NAGLU_C) | 5 | PHE A 309ALA A 804ASN A 780ILE A 603ASN A 604 | None | 1.14A | 2rlcA-2vcaA:undetectable | 2rlcA-2vcaA:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w4g | MYOSIN HEAVY CHAIN,SKELETAL MUSCLE,ADULT (Gallus gallus) |
PF00063(Myosin_head)PF02736(Myosin_N) | 5 | THR M 355ASN M 234ILE M 351ILE M 338LEU M 270 | None | 1.03A | 2rlcA-2w4gM:undetectable | 2rlcA-2w4gM:16.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w6d | DYNAMIN FAMILYPROTEIN (Nostocpunctiforme) |
PF00350(Dynamin_N) | 5 | THR A 565ASN A 427ILE A 561ILE A 452LEU A 426 | CPL A1705 (-3.7A)NoneCPL A1705 (-1.2A)CPL A1705 ( 4.8A)CPL A1708 (-4.9A) | 1.17A | 2rlcA-2w6dA:undetectable | 2rlcA-2w6dA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xfa | ACTINDEPOLYMERIZATIONFACTOR 2 (Plasmodiumberghei) |
PF00241(Cofilin_ADF) | 5 | ILE A 119PHE A 89ILE A 58ILE A 55LEU A 18 | None | 1.18A | 2rlcA-2xfaA:undetectable | 2rlcA-2xfaA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xka | FTSZ/TUBULIN-RELATEDPROTEIN (Bacillusthuringiensis) |
PF00091(Tubulin) | 5 | PHE A 308ALA A 311ILE A 219ILE A 220THR A 214 | None | 1.16A | 2rlcA-2xkaA:undetectable | 2rlcA-2xkaA:23.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zsg | AMINOPEPTIDASE P,PUTATIVE (Thermotogamaritima) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 5 | THR A 156ALA A 152ILE A 160ILE A 215LEU A 352 | None | 1.16A | 2rlcA-2zsgA:undetectable | 2rlcA-2zsgA:24.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b96 | VERY LONG-CHAINSPECIFIC ACYL-COADEHYDROGENASE (Homo sapiens) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | PHE A 219PHE A 174ILE A 144ILE A 296LEU A 165 | NoneMYA A 1 (-4.8A)MYA A 1 (-4.9A)NoneNone | 1.13A | 2rlcA-3b96A:undetectable | 2rlcA-3b96A:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clm | TRANSALDOLASE (Neisseriagonorrhoeae) |
PF00923(TAL_FSA) | 5 | ILE A 46THR A 289ILE A 202ASN A 283THR A 284 | NoneNoneNoneNoneEDO A 354 ( 4.9A) | 1.04A | 2rlcA-3clmA:undetectable | 2rlcA-3clmA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dto | BH2835 PROTEIN (Bacillushalodurans) |
PF01966(HD) | 5 | PHE A 57THR A 93ILE A 96ILE A 100ASN A 98 | None | 1.13A | 2rlcA-3dtoA:undetectable | 2rlcA-3dtoA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3enq | RIBOSE-5-PHOSPHATEISOMERASE A (Vibriovulnificus) |
PF06026(Rib_5-P_isom_A) | 5 | ILE A 105THR A 162ALA A 99ILE A 136THR A 194 | None | 0.93A | 2rlcA-3enqA:undetectable | 2rlcA-3enqA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3euw | MYO-INOSITOLDEHYDROGENASE (Corynebacteriumglutamicum) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | ALA A 18ASN A 24ILE A 67ILE A 88LEU A 288 | None | 1.13A | 2rlcA-3euwA:undetectable | 2rlcA-3euwA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f9i | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Rickettsiaprowazekii) |
PF13561(adh_short_C2) | 5 | ILE A 71ILE A 133ILE A 22THR A 12LEU A 61 | None | 1.16A | 2rlcA-3f9iA:undetectable | 2rlcA-3f9iA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gk0 | PYRIDOXINE5'-PHOSPHATESYNTHASE (Burkholderiapseudomallei) |
PF03740(PdxJ) | 5 | ILE A 225ALA A 46ASN A 16ILE A 216ASN A 197 | None | 1.08A | 2rlcA-3gk0A:undetectable | 2rlcA-3gk0A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gza | PUTATIVEALPHA-L-FUCOSIDASE (Bacteroidesthetaiotaomicron) |
PF01120(Alpha_L_fucos) | 5 | PHE A 301THR A 101ILE A 65ILE A 70LEU A 105 | None | 0.98A | 2rlcA-3gzaA:undetectable | 2rlcA-3gzaA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h1l | CYTOCHROME B (Gallus gallus) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B) | 5 | ILE C 95PHE C 96ILE C 301ILE C 305LEU C 122 | NonePEE C2007 (-3.9A)NoneNone3H1 C2001 ( 4.8A) | 1.18A | 2rlcA-3h1lC:undetectable | 2rlcA-3h1lC:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ij6 | UNCHARACTERIZEDMETAL-DEPENDENTHYDROLASE (Lactobacillusacidophilus) |
PF04909(Amidohydro_2) | 6 | THR A 236ALA A 248ILE A 276ILE A 275THR A 242LEU A 283 | None | 1.36A | 2rlcA-3ij6A:undetectable | 2rlcA-3ij6A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3izk | CHAPERONIN (Methanococcusmaripaludis) |
PF00118(Cpn60_TCP1) | 5 | ILE A 226PHE A 257ASN A 254ILE A 262ILE A 233 | None | 1.13A | 2rlcA-3izkA:undetectable | 2rlcA-3izkA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jcl | SPIKE GLYCOPROTEIN (Murinecoronavirus) |
PF01601(Corona_S2)PF09408(Spike_rec_bind)PF16451(Spike_NTD) | 5 | ALA A1075ILE A1113ILE A 872THR A 928LEU A 822 | None | 1.08A | 2rlcA-3jclA:undetectable | 2rlcA-3jclA:13.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jd5 | 28S RIBOSOMALPROTEIN S2,MITOCHONDRIAL (Bos taurus) |
PF00318(Ribosomal_S2) | 5 | ILE B 221PHE B 184PHE B 133ALA B 201ILE B 131 | None | 1.17A | 2rlcA-3jd5B:undetectable | 2rlcA-3jd5B:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k53 | FERROUS IRONTRANSPORT PROTEIN B (Pyrococcusfuriosus) |
PF02421(FeoB_N) | 5 | ILE A 131PHE A 119ILE A 88ASN A 97LEU A 94 | None | 1.14A | 2rlcA-3k53A:undetectable | 2rlcA-3k53A:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khj | INOSINE-5-MONOPHOSPHATE DEHYDROGENASE (Cryptosporidiumparvum) |
PF00478(IMPDH) | 5 | ILE A 185ASN A 38ILE A 46ILE A 250THR A 36 | None | 1.17A | 2rlcA-3khjA:undetectable | 2rlcA-3khjA:25.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kw7 | LACCASE B (Trametes sp.AH28-2) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | THR A 61ALA A 88ILE A 63ILE A 46LEU A 490 | None | 1.07A | 2rlcA-3kw7A:undetectable | 2rlcA-3kw7A:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lua | RESPONSE REGULATORRECEIVER PROTEIN (Ruminiclostridiumthermocellum) |
PF00072(Response_reg) | 5 | PHE A 43THR A 77ALA A 70ILE A 49ILE A 31 | None | 1.11A | 2rlcA-3luaA:undetectable | 2rlcA-3luaA:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nm1 | THIAMINEBIOSYNTHETICBIFUNCTIONAL ENZYME ([Candida]glabrata) |
PF02110(HK)PF02581(TMP-TENI) | 5 | ALA A 499ILE A 253ILE A 256ASN A 528THR A 525 | None | 1.15A | 2rlcA-3nm1A:undetectable | 2rlcA-3nm1A:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rcy | MANDELATERACEMASE/MUCONATELACTONIZINGENZYME-LIKE PROTEIN (Roseovarius sp.TM1035) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ARG A 111PHE A 324ALA A 115ILE A 328ASN A 122 | None | 1.17A | 2rlcA-3rcyA:undetectable | 2rlcA-3rcyA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT LNADH-QUINONEOXIDOREDUCTASESUBUNIT MNADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli;Escherichiacoli;Escherichiacoli) |
no annotationno annotationno annotation | 5 | ILE M 176ALA L 573ILE N 282ILE N 281LEU N 289 | None | 0.90A | 2rlcA-3rkoM:undetectable | 2rlcA-3rkoM:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sy6 | FIMBRIAL PROTEINBF1861 (Bacteroidesfragilis) |
PF13149(Mfa_like_1) | 5 | PHE A 94PHE A 57THR A 59ALA A 92ILE A 199 | None | 1.18A | 2rlcA-3sy6A:undetectable | 2rlcA-3sy6A:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tv2 | FUMARATE HYDRATASE,CLASS II (Burkholderiapseudomallei) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | ILE A 250ALA A 196ASN A 247ILE A 390ILE A 290 | None | 1.14A | 2rlcA-3tv2A:undetectable | 2rlcA-3tv2A:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tv2 | FUMARATE HYDRATASE,CLASS II (Burkholderiapseudomallei) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | ILE A 250ALA A 196ASN A 275ILE A 390ILE A 290 | None | 0.96A | 2rlcA-3tv2A:undetectable | 2rlcA-3tv2A:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vgo | E3 UBIQUITIN-PROTEINLIGASE CBL-B (Homo sapiens) |
PF02262(Cbl_N)PF02761(Cbl_N2)PF02762(Cbl_N3) | 5 | ILE A 235PHE A 231ALA A 155ILE A 109THR A 223 | None | 1.15A | 2rlcA-3vgoA:undetectable | 2rlcA-3vgoA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zuq | BOTULINUM NEUROTOXINTYPE B (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07952(Toxin_trans) | 5 | ILE A 750PHE A 747ALA A 683ILE A 883ASN A 808 | None | 1.18A | 2rlcA-3zuqA:undetectable | 2rlcA-3zuqA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dng | UNCHARACTERIZEDALDEHYDEDEHYDROGENASE ALDY (Bacillussubtilis) |
PF00171(Aldedh) | 5 | ILE A 276PHE A 280PHE A 383ALA A 387ASN A 258 | None | 0.99A | 2rlcA-4dngA:undetectable | 2rlcA-4dngA:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dqv | PROBABLE PEPTIDESYNTHETASE NRP(PEPTIDE SYNTHASE) (Mycobacteriumtuberculosis) |
PF07993(NAD_binding_4) | 5 | PHE A 418THR A 415ALA A 413ILE A 436ASN A 339 | None | 1.12A | 2rlcA-4dqvA:undetectable | 2rlcA-4dqvA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ecn | LEUCINE-RICH REPEATPROTEIN (Bacteroidesthetaiotaomicron) |
PF14660(DUF4458) | 5 | ALA A 722ASN A 751ILE A 730ILE A 761THR A 755 | None | 1.13A | 2rlcA-4ecnA:undetectable | 2rlcA-4ecnA:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fai | CG5976, ISOFORM B (Drosophilamelanogaster) |
PF04389(Peptidase_M28) | 5 | ILE A 202ALA A 209ILE A 121ILE A 120LEU A 224 | None | 1.10A | 2rlcA-4faiA:undetectable | 2rlcA-4faiA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hds | ARSA (Sporomusa ovata) |
PF02277(DBI_PRT) | 5 | ILE A 160ALA A 65ILE A 275ILE A 279LEU A 174 | None | 0.97A | 2rlcA-4hdsA:undetectable | 2rlcA-4hdsA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ifq | NUCLEOPORIN NUP192 (Saccharomycescerevisiae) |
PF11894(Nup192) | 5 | ILE A 836PHE A 713ILE A 717ILE A 749LEU A 788 | None | 1.08A | 2rlcA-4ifqA:undetectable | 2rlcA-4ifqA:15.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jpd | PROTEIN CYAY (Burkholderiacenocepacia) |
PF01491(Frataxin_Cyay) | 5 | PHE A 89THR A 20ALA A 16ILE A 104LEU A 40 | None | 1.12A | 2rlcA-4jpdA:undetectable | 2rlcA-4jpdA:16.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lxy | WLARD, A SUGAR3N-FORMYLTRANSFERASE (Campylobacterjejuni) |
PF00551(Formyl_trans_N) | 5 | ILE A 65PHE A 73ALA A 7ILE A 169ILE A 173 | None | 0.95A | 2rlcA-4lxyA:undetectable | 2rlcA-4lxyA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mo2 | UDP-GALACTOPYRANOSEMUTASE (Campylobacterjejuni) |
no annotation | 5 | ILE B 188PHE B 284ALA B 55ILE B 45THR B 42 | None | 1.11A | 2rlcA-4mo2B:undetectable | 2rlcA-4mo2B:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4myo | VIRGINIAMYCIN AACETYLTRANSFERASE (Staphylococcusaureus) |
PF00132(Hexapep) | 5 | PHE A 51THR A 29ILE A 26ILE A 74LEU A 15 | None | 1.10A | 2rlcA-4myoA:undetectable | 2rlcA-4myoA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ntj | P2Y PURINOCEPTOR12,SOLUBLECYTOCHROME B562,P2YPURINOCEPTOR 12 (Escherichiacoli;Homo sapiens) |
PF00001(7tm_1)PF07361(Cytochrom_B562) | 6 | PHE A 305ALA A 46ASN A 294ILE A 61ASN A 65THR A 66 | None | 1.34A | 2rlcA-4ntjA:undetectable | 2rlcA-4ntjA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oya | ADENYLATE CYCLASETYPE 10 (Homo sapiens) |
PF00211(Guanylate_cyc) | 5 | ALA A 182ASN A 185ILE A 204ILE A 202ASN A 216 | None | 1.05A | 2rlcA-4oyaA:undetectable | 2rlcA-4oyaA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5adv | ENTEROCHELIN UPTAKEPERIPLASMIC BINDINGPROTEIN (Campylobacterjejuni) |
PF01497(Peripla_BP_2) | 5 | PHE A 245ALA A 199ASN A 221ILE A 209ILE A 215 | None | 1.00A | 2rlcA-5advA:undetectable | 2rlcA-5advA:24.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b5x | LIMITINGCO2-INDUCIBLEPROTEIN LCIC (Chlamydomonasreinhardtii) |
no annotation | 5 | ILE A 296ALA A 202ILE A 269THR A 262LEU A 258 | None | 1.08A | 2rlcA-5b5xA:undetectable | 2rlcA-5b5xA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eyw | TRIOSEPHOSPHATEISOMERASE (Litopenaeusvannamei) |
PF00121(TIM) | 5 | ILE A 244PHE A 230ALA A 222ASN A 246THR A 38 | None | 0.85A | 2rlcA-5eywA:undetectable | 2rlcA-5eywA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gkq | ALYGC MUTANT - R241A (Paraglaciecolachathamensis) |
PF14592(Chondroitinas_B) | 5 | PHE A 207ASN A 315ILE A 216ILE A 217LEU A 278 | None | 1.13A | 2rlcA-5gkqA:undetectable | 2rlcA-5gkqA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gw5 | T-COMPLEX PROTEIN 1SUBUNIT ALPHA (Saccharomycescerevisiae) |
PF00118(Cpn60_TCP1) | 5 | PHE a 139PHE a 436ALA a 428ILE a 448LEU a 455 | None | 0.98A | 2rlcA-5gw5a:undetectable | 2rlcA-5gw5a:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h42 | UNCHARACTERIZEDPROTEIN (Lachnoclostridiumphytofermentans) |
PF17167(Glyco_hydro_36) | 5 | PHE A1107ALA A1100ASN A1073ILE A1090ILE A1067 | None | 1.08A | 2rlcA-5h42A:undetectable | 2rlcA-5h42A:13.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ig2 | SHORT-CHAINDEHYDROGENASE/REDUCTASE SDR (Paraburkholderiaphymatum) |
PF00106(adh_short) | 5 | ILE A 11ALA A 238ILE A 195THR A 141LEU A 186 | NoneNoneNAD A 301 (-3.6A)NAD A 301 (-3.9A)None | 1.12A | 2rlcA-5ig2A:undetectable | 2rlcA-5ig2A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ik2 | ATP SYNTHASE SUBUNITALPHAATP SYNTHASE GAMMACHAIN (Caldalkalibacillusthermarum;Caldalkalibacillusthermarum) |
PF00006(ATP-synt_ab)PF00306(ATP-synt_ab_C)PF02874(ATP-synt_ab_N)PF00231(ATP-synt) | 5 | ARG G 5PHE A 343ALA A 323ILE A 168ILE A 335 | None | 1.14A | 2rlcA-5ik2G:undetectable | 2rlcA-5ik2G:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j72 | PUTATIVEN-ACETYLMURAMOYL-L-ALANINEAMIDASE,AUTOLYSINCWP6 (Clostridioidesdifficile) |
PF01520(Amidase_3)PF04122(CW_binding_2) | 5 | ILE A 323THR A 183ALA A 289ILE A 387ILE A 383 | None | 1.13A | 2rlcA-5j72A:undetectable | 2rlcA-5j72A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nil | MACROLIDE EXPORTATP-BINDING/PERMEASEPROTEIN MACB (Escherichiacoli) |
PF00005(ABC_tran)PF02687(FtsX)PF12704(MacB_PCD) | 5 | ILE J 279ALA J 576ASN J 268THR J 272LEU J 265 | None | 1.09A | 2rlcA-5nilJ:undetectable | 2rlcA-5nilJ:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o8f | GAMMA-AMINOBUTYRICACID RECEPTORSUBUNITBETA-3,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNITALPHA-5,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNIT ALPHA-5 (Homo sapiens) |
no annotation | 5 | PHE A 212ALA A 135ILE A 47ILE A 44THR A 132 | None | 0.99A | 2rlcA-5o8fA:undetectable | 2rlcA-5o8fA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5olk | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE,BETA SUBUNIT 1 (Leeuwenhoekiellablandensis) |
no annotation | 5 | ILE A 169PHE A 196ILE A 128ILE A 300THR A 294 | None | 1.15A | 2rlcA-5olkA:undetectable | 2rlcA-5olkA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5upr | TRIOSEPHOSPHATEISOMERASE (Toxoplasmagondii) |
PF00121(TIM) | 5 | PHE A 121ALA A 327ILE A 331ILE A 245LEU A 316 | None | 0.95A | 2rlcA-5uprA:undetectable | 2rlcA-5uprA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vwn | TRIOSEPHOSPHATEISOMERASE (Trichomonasvaginalis) |
no annotation | 5 | ILE A 238PHE A 224ALA A 216ASN A 240ASN A 35 | None | 1.07A | 2rlcA-5vwnA:undetectable | 2rlcA-5vwnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wlh | LBACAS13A H328A(C2C2) (LachnospiraceaebacteriumNK4A179) |
no annotation | 5 | PHE A1259PHE A1365ALA A1112ILE A1361ILE A1327 | None | 1.18A | 2rlcA-5wlhA:undetectable | 2rlcA-5wlhA:12.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wls | POLLEN RECEPTOR-LIKEKINASE 3 (Arabidopsisthaliana) |
no annotation | 5 | ILE A 60PHE A 110ILE A 84ILE A 82LEU A 29 | None | 1.02A | 2rlcA-5wlsA:undetectable | 2rlcA-5wlsA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xog | DNA-DIRECTED RNAPOLYMERASE SUBUNIT (Komagataellaphaffii) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 5 | PHE A 800THR A 722ALA A 726ILE A 694ILE A 695 | None | 0.93A | 2rlcA-5xogA:undetectable | 2rlcA-5xogA:10.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z95 | - (-) |
no annotation | 5 | ILE A 80PHE A 62ALA A 7ILE A 185ILE A 189 | None | 1.14A | 2rlcA-5z95A:undetectable | 2rlcA-5z95A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bka | NITRONATEMONOOXYGENASE (Cyberlindneramrakii) |
no annotation | 5 | PHE A 176ALA A 238ILE A 220ILE A 224LEU A 250 | NoneFMN A 401 ( 4.0A)NoneNoneNone | 1.09A | 2rlcA-6bkaA:undetectable | 2rlcA-6bkaA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6byq | TYROSINE--TRNALIGASE (Helicobacterpylori) |
no annotation | 5 | ILE A 60PHE A 45PHE A 126ALA A 43THR A 122 | None | 1.12A | 2rlcA-6byqA:undetectable | 2rlcA-6byqA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d43 | TRIOSEPHOSPHATEISOMERASE (Homo sapiens) |
no annotation | 5 | ILE B 243PHE B 229ALA B 221ASN B 245THR B 37 | None | 0.96A | 2rlcA-6d43B:undetectable | 2rlcA-6d43B:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dku | VP35 (Myotislucifugus) |
no annotation | 5 | PHE A 228ALA A 200ILE A 219ILE A 281LEU A 169 | None | 1.11A | 2rlcA-6dkuA:undetectable | 2rlcA-6dkuA:undetectable |