SIMILAR PATTERNS OF AMINO ACIDS FOR 2RLC_A_CHDA332

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aha ALPHA-MOMORCHARIN

(Momordica
charantia)
PF00161
(RIP)
5 ILE A  60
THR A 157
ASN A  54
ILE A 127
LEU A   6
None
1.16A 2rlcA-1ahaA:
0.0
2rlcA-1ahaA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ati GLYCYL-TRNA
SYNTHETASE


(Thermus
thermophilus)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
5 ARG A 260
PHE A 230
ALA A 362
ILE A 229
LEU A  45
None
1.09A 2rlcA-1atiA:
0.0
2rlcA-1atiA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggp PROTEIN (LECTIN 1 A
CHAIN)


(Trichosanthes
kirilowii)
PF00161
(RIP)
5 THR A 236
ALA A 238
ILE A 227
ILE A 228
LEU A 201
None
1.02A 2rlcA-1ggpA:
0.0
2rlcA-1ggpA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE


(Bos taurus)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
5 ILE A 338
THR A 361
ALA A 358
ILE A 421
LEU A 436
None
1.04A 2rlcA-1lamA:
0.0
2rlcA-1lamA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr3 DNA-BINDING PROTEIN
TFX


(Methanothermobacter
thermautotrophicus)
PF14601
(TFX_C)
5 ALA A  24
ILE A  79
ILE A  11
THR A  84
LEU A  88
None
1.17A 2rlcA-1nr3A:
0.0
2rlcA-1nr3A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq7 TRIOSEPHOSPHATE
ISOMERASE


(Gallus gallus)
PF00121
(TIM)
5 ILE A 243
PHE A 229
ALA A 221
ASN A 245
THR A  37
None
0.85A 2rlcA-1sq7A:
0.0
2rlcA-1sq7A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32)
PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ)
5 ILE A 413
PHE A 296
ALA A 331
ILE A 300
ILE A 316
None
1.05A 2rlcA-1t1eA:
0.0
2rlcA-1t1eA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t71 PHOSPHATASE

(Mycoplasma
pneumoniae)
PF13277
(YmdB)
5 ILE A 145
PHE A 172
ASN A 122
THR A 121
LEU A  93
None
1.10A 2rlcA-1t71A:
0.0
2rlcA-1t71A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr1 BETA-GLUCOSIDASE A

(Paenibacillus
polymyxa)
PF00232
(Glyco_hydro_1)
5 ILE A 170
PHE A 164
ALA A 200
ILE A 288
ILE A 291
None
1.16A 2rlcA-1tr1A:
undetectable
2rlcA-1tr1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT


(Saccharomyces
cerevisiae)
PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3)
5 ILE B 430
ALA B 451
ASN B 473
ILE B 376
ILE B 380
None
1.18A 2rlcA-1wa5B:
undetectable
2rlcA-1wa5B:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens)
PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C)
5 THR A 620
ALA A 696
ILE A 576
ILE A 605
LEU A 682
None
1.14A 2rlcA-1x9nA:
undetectable
2rlcA-1x9nA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE


(Plasmodium
falciparum)
PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C)
5 PHE A 203
ALA A 179
ASN A  78
ILE A 108
LEU A  87
None
1.06A 2rlcA-1yj8A:
undetectable
2rlcA-1yj8A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1


(Saccharomyces
cerevisiae)
PF00266
(Aminotran_5)
5 PHE A 185
THR A 197
ALA A 195
ILE A 203
ILE A 274
None
0.89A 2rlcA-2bkwA:
undetectable
2rlcA-2bkwA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmx ALKYL
HYDROPEROXIDASE C


(Mycobacterium
tuberculosis)
PF00578
(AhpC-TSA)
6 ILE A 144
PHE A 136
PHE A  51
ALA A 122
ASN A 142
ILE A  82
None
1.37A 2rlcA-2bmxA:
undetectable
2rlcA-2bmxA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE


(Desulfovibrio
africanus)
PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II)
5 PHE A 470
ALA A 566
ASN A 560
ILE A 441
ILE A 438
None
1.17A 2rlcA-2c3oA:
undetectable
2rlcA-2c3oA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwl MANGANESE-FREE
PSEUDOCATALASE


(Thermus
thermophilus)
PF05067
(Mn_catalase)
5 ILE A 178
ALA A  25
ASN A  82
THR A  80
LEU A  84
None
1.07A 2rlcA-2cwlA:
undetectable
2rlcA-2cwlA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esr METHYLTRANSFERASE

(Streptococcus
pyogenes)
PF03602
(Cons_hypoth95)
5 ILE A  32
PHE A 115
ALA A  59
ILE A  80
ASN A  83
None
1.16A 2rlcA-2esrA:
undetectable
2rlcA-2esrA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2


(Pseudomonas
syringae)
PF05721
(PhyH)
5 PHE A  24
ALA A 147
ILE A 228
ILE A  21
LEU A 158
None
1.16A 2rlcA-2fctA:
undetectable
2rlcA-2fctA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Sulfurisphaera
tokodaii)
PF00132
(Hexapep)
PF00483
(NTP_transferase)
5 ILE A 167
PHE A 168
ALA A  87
ILE A  77
LEU A   6
None
None
None
None
TTP  A 500 (-4.0A)
1.07A 2rlcA-2ggqA:
undetectable
2rlcA-2ggqA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9e TRIOSEPHOSPHATE
ISOMERASE


(Tenebrio
molitor)
PF00121
(TIM)
5 ILE A 242
PHE A 228
ALA A 220
ASN A 244
THR A  36
None
0.90A 2rlcA-2i9eA:
undetectable
2rlcA-2i9eA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ib5 CHROMO PROTEIN

(Epiactis
japonica)
PF01353
(GFP)
5 PHE A 211
THR A  59
ILE A 201
THR A 137
LEU A 162
None
0.97A 2rlcA-2ib5A:
undetectable
2rlcA-2ib5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE


(Neurospora
crassa)
PF05183
(RdRP)
5 ILE A 565
ALA A1076
ILE A 608
ILE A 607
THR A 544
None
1.10A 2rlcA-2j7nA:
undetectable
2rlcA-2j7nA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A


(Homo sapiens)
PF14580
(LRR_9)
5 ILE A  57
PHE A  41
ASN A  74
ILE A   7
THR A  49
None
1.14A 2rlcA-2je1A:
undetectable
2rlcA-2je1A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A


(Mus musculus)
PF14580
(LRR_9)
5 ILE A  57
PHE A  41
ASN A  74
ILE A   7
THR A  49
None
1.09A 2rlcA-2jqdA:
undetectable
2rlcA-2jqdA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l10 TALIN-1

(Mus musculus)
PF08913
(VBS)
5 PHE A1281
ALA A1215
ILE A1308
ILE A1346
LEU A1316
None
1.04A 2rlcA-2l10A:
undetectable
2rlcA-2l10A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph0 UNCHARACTERIZED
PROTEIN


(Pectobacterium
carotovorum)
PF06228
(ChuX_HutX)
5 ILE A  64
PHE A 137
PHE A 110
ILE A 108
LEU A  28
None
1.00A 2rlcA-2ph0A:
undetectable
2rlcA-2ph0A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psf RENILLA-LUCIFERIN
2-MONOOXYGENASE


(Renilla
reniformis)
PF00561
(Abhydrolase_1)
5 ARG A 136
ILE A 137
PHE A 116
PHE A  49
ILE A  67
None
1.14A 2rlcA-2psfA:
undetectable
2rlcA-2psfA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q07 UNCHARACTERIZED
PROTEIN AF0587


(Archaeoglobus
fulgidus)
PF01472
(PUA)
5 PHE A 499
ALA A 452
ASN A 458
ILE A 520
THR A 461
None
1.12A 2rlcA-2q07A:
undetectable
2rlcA-2q07A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE


(Pyrococcus
abyssi)
PF00144
(Beta-lactamase)
PF13969
(Pab87_oct)
5 PHE A 142
PHE A 120
ILE A 231
ASN A 162
THR A 163
None
1.15A 2rlcA-2qmiA:
undetectable
2rlcA-2qmiA:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rg2 CHOLOYLGLYCINE
HYDROLASE


(Clostridium
perfringens)
PF02275
(CBAH)
7 ILE A  22
PHE A  26
ALA A  68
ASN A  82
ILE A 137
THR A 140
LEU A 142
None
EDO  A 334 (-4.2A)
EDO  A 333 ( 3.7A)
GOL  A 336 (-3.7A)
None
None
EDO  A 333 ( 4.5A)
1.05A 2rlcA-2rg2A:
53.5
2rlcA-2rg2A:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rg2 CHOLOYLGLYCINE
HYDROLASE


(Clostridium
perfringens)
PF02275
(CBAH)
9 ILE A  22
PHE A  26
THR A  66
ALA A  68
ASN A  82
ILE A 133
ASN A 139
THR A 140
LEU A 142
None
EDO  A 334 (-4.2A)
EDO  A 334 (-3.4A)
EDO  A 333 ( 3.7A)
GOL  A 336 (-3.7A)
None
None
None
EDO  A 333 ( 4.5A)
0.45A 2rlcA-2rg2A:
53.5
2rlcA-2rg2A:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rg2 CHOLOYLGLYCINE
HYDROLASE


(Clostridium
perfringens)
PF02275
(CBAH)
8 ILE A  22
THR A  66
ASN A  82
ILE A 133
ILE A 137
ASN A 139
THR A 140
LEU A 142
None
EDO  A 334 (-3.4A)
GOL  A 336 (-3.7A)
None
None
None
None
EDO  A 333 ( 4.5A)
0.84A 2rlcA-2rg2A:
53.5
2rlcA-2rg2A:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rg2 CHOLOYLGLYCINE
HYDROLASE


(Clostridium
perfringens)
PF02275
(CBAH)
6 PHE A  61
ASN A  82
ILE A 133
ILE A 137
ASN A 139
THR A 140
None
GOL  A 336 (-3.7A)
None
None
None
None
0.96A 2rlcA-2rg2A:
53.5
2rlcA-2rg2A:
99.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8n LACTOSE PERMEASE

(Escherichia
coli)
PF01306
(LacY_symp)
5 ILE A  52
PHE A  27
PHE A  29
ILE A  32
ILE A  37
None
1.15A 2rlcA-2v8nA:
undetectable
2rlcA-2v8nA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE


(Clostridium
perfringens)
PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C)
5 ILE A 124
ALA A  96
ILE A  67
ILE A 147
LEU A  71
None
1.06A 2rlcA-2vcaA:
undetectable
2rlcA-2vcaA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE


(Clostridium
perfringens)
PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C)
5 PHE A 309
ALA A 804
ASN A 780
ILE A 603
ASN A 604
None
1.14A 2rlcA-2vcaA:
undetectable
2rlcA-2vcaA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT


(Gallus gallus)
PF00063
(Myosin_head)
PF02736
(Myosin_N)
5 THR M 355
ASN M 234
ILE M 351
ILE M 338
LEU M 270
None
1.03A 2rlcA-2w4gM:
undetectable
2rlcA-2w4gM:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN


(Nostoc
punctiforme)
PF00350
(Dynamin_N)
5 THR A 565
ASN A 427
ILE A 561
ILE A 452
LEU A 426
CPL  A1705 (-3.7A)
None
CPL  A1705 (-1.2A)
CPL  A1705 ( 4.8A)
CPL  A1708 (-4.9A)
1.17A 2rlcA-2w6dA:
undetectable
2rlcA-2w6dA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfa ACTIN
DEPOLYMERIZATION
FACTOR 2


(Plasmodium
berghei)
PF00241
(Cofilin_ADF)
5 ILE A 119
PHE A  89
ILE A  58
ILE A  55
LEU A  18
None
1.18A 2rlcA-2xfaA:
undetectable
2rlcA-2xfaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xka FTSZ/TUBULIN-RELATED
PROTEIN


(Bacillus
thuringiensis)
PF00091
(Tubulin)
5 PHE A 308
ALA A 311
ILE A 219
ILE A 220
THR A 214
None
1.16A 2rlcA-2xkaA:
undetectable
2rlcA-2xkaA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsg AMINOPEPTIDASE P,
PUTATIVE


(Thermotoga
maritima)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
5 THR A 156
ALA A 152
ILE A 160
ILE A 215
LEU A 352
None
1.16A 2rlcA-2zsgA:
undetectable
2rlcA-2zsgA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE


(Homo sapiens)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 PHE A 219
PHE A 174
ILE A 144
ILE A 296
LEU A 165
None
MYA  A   1 (-4.8A)
MYA  A   1 (-4.9A)
None
None
1.13A 2rlcA-3b96A:
undetectable
2rlcA-3b96A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clm TRANSALDOLASE

(Neisseria
gonorrhoeae)
PF00923
(TAL_FSA)
5 ILE A  46
THR A 289
ILE A 202
ASN A 283
THR A 284
None
None
None
None
EDO  A 354 ( 4.9A)
1.04A 2rlcA-3clmA:
undetectable
2rlcA-3clmA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dto BH2835 PROTEIN

(Bacillus
halodurans)
PF01966
(HD)
5 PHE A  57
THR A  93
ILE A  96
ILE A 100
ASN A  98
None
1.13A 2rlcA-3dtoA:
undetectable
2rlcA-3dtoA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enq RIBOSE-5-PHOSPHATE
ISOMERASE A


(Vibrio
vulnificus)
PF06026
(Rib_5-P_isom_A)
5 ILE A 105
THR A 162
ALA A  99
ILE A 136
THR A 194
None
0.93A 2rlcA-3enqA:
undetectable
2rlcA-3enqA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euw MYO-INOSITOL
DEHYDROGENASE


(Corynebacterium
glutamicum)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 ALA A  18
ASN A  24
ILE A  67
ILE A  88
LEU A 288
None
1.13A 2rlcA-3euwA:
undetectable
2rlcA-3euwA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9i 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Rickettsia
prowazekii)
PF13561
(adh_short_C2)
5 ILE A  71
ILE A 133
ILE A  22
THR A  12
LEU A  61
None
1.16A 2rlcA-3f9iA:
undetectable
2rlcA-3f9iA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE


(Burkholderia
pseudomallei)
PF03740
(PdxJ)
5 ILE A 225
ALA A  46
ASN A  16
ILE A 216
ASN A 197
None
1.08A 2rlcA-3gk0A:
undetectable
2rlcA-3gk0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gza PUTATIVE
ALPHA-L-FUCOSIDASE


(Bacteroides
thetaiotaomicron)
PF01120
(Alpha_L_fucos)
5 PHE A 301
THR A 101
ILE A  65
ILE A  70
LEU A 105
None
0.98A 2rlcA-3gzaA:
undetectable
2rlcA-3gzaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l CYTOCHROME B

(Gallus gallus)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
5 ILE C  95
PHE C  96
ILE C 301
ILE C 305
LEU C 122
None
PEE  C2007 (-3.9A)
None
None
3H1  C2001 ( 4.8A)
1.18A 2rlcA-3h1lC:
undetectable
2rlcA-3h1lC:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE


(Lactobacillus
acidophilus)
PF04909
(Amidohydro_2)
6 THR A 236
ALA A 248
ILE A 276
ILE A 275
THR A 242
LEU A 283
None
1.36A 2rlcA-3ij6A:
undetectable
2rlcA-3ij6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izk CHAPERONIN

(Methanococcus
maripaludis)
PF00118
(Cpn60_TCP1)
5 ILE A 226
PHE A 257
ASN A 254
ILE A 262
ILE A 233
None
1.13A 2rlcA-3izkA:
undetectable
2rlcA-3izkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus)
PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD)
5 ALA A1075
ILE A1113
ILE A 872
THR A 928
LEU A 822
None
1.08A 2rlcA-3jclA:
undetectable
2rlcA-3jclA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S2,
MITOCHONDRIAL


(Bos taurus)
PF00318
(Ribosomal_S2)
5 ILE B 221
PHE B 184
PHE B 133
ALA B 201
ILE B 131
None
1.17A 2rlcA-3jd5B:
undetectable
2rlcA-3jd5B:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k53 FERROUS IRON
TRANSPORT PROTEIN B


(Pyrococcus
furiosus)
PF02421
(FeoB_N)
5 ILE A 131
PHE A 119
ILE A  88
ASN A  97
LEU A  94
None
1.14A 2rlcA-3k53A:
undetectable
2rlcA-3k53A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khj INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE


(Cryptosporidium
parvum)
PF00478
(IMPDH)
5 ILE A 185
ASN A  38
ILE A  46
ILE A 250
THR A  36
None
1.17A 2rlcA-3khjA:
undetectable
2rlcA-3khjA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
5 THR A  61
ALA A  88
ILE A  63
ILE A  46
LEU A 490
None
1.07A 2rlcA-3kw7A:
undetectable
2rlcA-3kw7A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lua RESPONSE REGULATOR
RECEIVER PROTEIN


(Ruminiclostridium
thermocellum)
PF00072
(Response_reg)
5 PHE A  43
THR A  77
ALA A  70
ILE A  49
ILE A  31
None
1.11A 2rlcA-3luaA:
undetectable
2rlcA-3luaA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME


([Candida]
glabrata)
PF02110
(HK)
PF02581
(TMP-TENI)
5 ALA A 499
ILE A 253
ILE A 256
ASN A 528
THR A 525
None
1.15A 2rlcA-3nm1A:
undetectable
2rlcA-3nm1A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN


(Roseovarius sp.
TM1035)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ARG A 111
PHE A 324
ALA A 115
ILE A 328
ASN A 122
None
1.17A 2rlcA-3rcyA:
undetectable
2rlcA-3rcyA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N


(Escherichia
coli;
Escherichia
coli;
Escherichia
coli)
no annotation
no annotation
no annotation
5 ILE M 176
ALA L 573
ILE N 282
ILE N 281
LEU N 289
None
0.90A 2rlcA-3rkoM:
undetectable
2rlcA-3rkoM:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy6 FIMBRIAL PROTEIN
BF1861


(Bacteroides
fragilis)
PF13149
(Mfa_like_1)
5 PHE A  94
PHE A  57
THR A  59
ALA A  92
ILE A 199
None
1.18A 2rlcA-3sy6A:
undetectable
2rlcA-3sy6A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tv2 FUMARATE HYDRATASE,
CLASS II


(Burkholderia
pseudomallei)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
5 ILE A 250
ALA A 196
ASN A 247
ILE A 390
ILE A 290
None
1.14A 2rlcA-3tv2A:
undetectable
2rlcA-3tv2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tv2 FUMARATE HYDRATASE,
CLASS II


(Burkholderia
pseudomallei)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
5 ILE A 250
ALA A 196
ASN A 275
ILE A 390
ILE A 290
None
0.96A 2rlcA-3tv2A:
undetectable
2rlcA-3tv2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgo E3 UBIQUITIN-PROTEIN
LIGASE CBL-B


(Homo sapiens)
PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3)
5 ILE A 235
PHE A 231
ALA A 155
ILE A 109
THR A 223
None
1.15A 2rlcA-3vgoA:
undetectable
2rlcA-3vgoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07952
(Toxin_trans)
5 ILE A 750
PHE A 747
ALA A 683
ILE A 883
ASN A 808
None
1.18A 2rlcA-3zuqA:
undetectable
2rlcA-3zuqA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY


(Bacillus
subtilis)
PF00171
(Aldedh)
5 ILE A 276
PHE A 280
PHE A 383
ALA A 387
ASN A 258
None
0.99A 2rlcA-4dngA:
undetectable
2rlcA-4dngA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)


(Mycobacterium
tuberculosis)
PF07993
(NAD_binding_4)
5 PHE A 418
THR A 415
ALA A 413
ILE A 436
ASN A 339
None
1.12A 2rlcA-4dqvA:
undetectable
2rlcA-4dqvA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN


(Bacteroides
thetaiotaomicron)
PF14660
(DUF4458)
5 ALA A 722
ASN A 751
ILE A 730
ILE A 761
THR A 755
None
1.13A 2rlcA-4ecnA:
undetectable
2rlcA-4ecnA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fai CG5976, ISOFORM B

(Drosophila
melanogaster)
PF04389
(Peptidase_M28)
5 ILE A 202
ALA A 209
ILE A 121
ILE A 120
LEU A 224
None
1.10A 2rlcA-4faiA:
undetectable
2rlcA-4faiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSA

(Sporomusa ovata)
PF02277
(DBI_PRT)
5 ILE A 160
ALA A  65
ILE A 275
ILE A 279
LEU A 174
None
0.97A 2rlcA-4hdsA:
undetectable
2rlcA-4hdsA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae)
PF11894
(Nup192)
5 ILE A 836
PHE A 713
ILE A 717
ILE A 749
LEU A 788
None
1.08A 2rlcA-4ifqA:
undetectable
2rlcA-4ifqA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpd PROTEIN CYAY

(Burkholderia
cenocepacia)
PF01491
(Frataxin_Cyay)
5 PHE A  89
THR A  20
ALA A  16
ILE A 104
LEU A  40
None
1.12A 2rlcA-4jpdA:
undetectable
2rlcA-4jpdA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxy WLARD, A SUGAR
3N-FORMYL
TRANSFERASE


(Campylobacter
jejuni)
PF00551
(Formyl_trans_N)
5 ILE A  65
PHE A  73
ALA A   7
ILE A 169
ILE A 173
None
0.95A 2rlcA-4lxyA:
undetectable
2rlcA-4lxyA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo2 UDP-GALACTOPYRANOSE
MUTASE


(Campylobacter
jejuni)
no annotation 5 ILE B 188
PHE B 284
ALA B  55
ILE B  45
THR B  42
None
1.11A 2rlcA-4mo2B:
undetectable
2rlcA-4mo2B:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myo VIRGINIAMYCIN A
ACETYLTRANSFERASE


(Staphylococcus
aureus)
PF00132
(Hexapep)
5 PHE A  51
THR A  29
ILE A  26
ILE A  74
LEU A  15
None
1.10A 2rlcA-4myoA:
undetectable
2rlcA-4myoA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntj P2Y PURINOCEPTOR
12,SOLUBLE
CYTOCHROME B562,P2Y
PURINOCEPTOR 12


(Escherichia
coli;
Homo sapiens)
PF00001
(7tm_1)
PF07361
(Cytochrom_B562)
6 PHE A 305
ALA A  46
ASN A 294
ILE A  61
ASN A  65
THR A  66
None
1.34A 2rlcA-4ntjA:
undetectable
2rlcA-4ntjA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10


(Homo sapiens)
PF00211
(Guanylate_cyc)
5 ALA A 182
ASN A 185
ILE A 204
ILE A 202
ASN A 216
None
1.05A 2rlcA-4oyaA:
undetectable
2rlcA-4oyaA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN


(Campylobacter
jejuni)
PF01497
(Peripla_BP_2)
5 PHE A 245
ALA A 199
ASN A 221
ILE A 209
ILE A 215
None
1.00A 2rlcA-5advA:
undetectable
2rlcA-5advA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC


(Chlamydomonas
reinhardtii)
no annotation 5 ILE A 296
ALA A 202
ILE A 269
THR A 262
LEU A 258
None
1.08A 2rlcA-5b5xA:
undetectable
2rlcA-5b5xA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyw TRIOSEPHOSPHATE
ISOMERASE


(Litopenaeus
vannamei)
PF00121
(TIM)
5 ILE A 244
PHE A 230
ALA A 222
ASN A 246
THR A  38
None
0.85A 2rlcA-5eywA:
undetectable
2rlcA-5eywA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis)
PF14592
(Chondroitinas_B)
5 PHE A 207
ASN A 315
ILE A 216
ILE A 217
LEU A 278
None
1.13A 2rlcA-5gkqA:
undetectable
2rlcA-5gkqA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00118
(Cpn60_TCP1)
5 PHE a 139
PHE a 436
ALA a 428
ILE a 448
LEU a 455
None
0.98A 2rlcA-5gw5a:
undetectable
2rlcA-5gw5a:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN


(Lachnoclostridium
phytofermentans)
PF17167
(Glyco_hydro_36)
5 PHE A1107
ALA A1100
ASN A1073
ILE A1090
ILE A1067
None
1.08A 2rlcA-5h42A:
undetectable
2rlcA-5h42A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Paraburkholderia
phymatum)
PF00106
(adh_short)
5 ILE A  11
ALA A 238
ILE A 195
THR A 141
LEU A 186
None
None
NAD  A 301 (-3.6A)
NAD  A 301 (-3.9A)
None
1.12A 2rlcA-5ig2A:
undetectable
2rlcA-5ig2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA
ATP SYNTHASE GAMMA
CHAIN


(Caldalkalibacillus
thermarum;
Caldalkalibacillus
thermarum)
PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
PF00231
(ATP-synt)
5 ARG G   5
PHE A 343
ALA A 323
ILE A 168
ILE A 335
None
1.14A 2rlcA-5ik2G:
undetectable
2rlcA-5ik2G:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j72 PUTATIVE
N-ACETYLMURAMOYL-L-A
LANINE
AMIDASE,AUTOLYSIN
CWP6


(Clostridioides
difficile)
PF01520
(Amidase_3)
PF04122
(CW_binding_2)
5 ILE A 323
THR A 183
ALA A 289
ILE A 387
ILE A 383
None
1.13A 2rlcA-5j72A:
undetectable
2rlcA-5j72A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nil MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB


(Escherichia
coli)
PF00005
(ABC_tran)
PF02687
(FtsX)
PF12704
(MacB_PCD)
5 ILE J 279
ALA J 576
ASN J 268
THR J 272
LEU J 265
None
1.09A 2rlcA-5nilJ:
undetectable
2rlcA-5nilJ:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5


(Homo sapiens)
no annotation 5 PHE A 212
ALA A 135
ILE A  47
ILE A  44
THR A 132
None
0.99A 2rlcA-5o8fA:
undetectable
2rlcA-5o8fA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1


(Leeuwenhoekiella
blandensis)
no annotation 5 ILE A 169
PHE A 196
ILE A 128
ILE A 300
THR A 294
None
1.15A 2rlcA-5olkA:
undetectable
2rlcA-5olkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upr TRIOSEPHOSPHATE
ISOMERASE


(Toxoplasma
gondii)
PF00121
(TIM)
5 PHE A 121
ALA A 327
ILE A 331
ILE A 245
LEU A 316
None
0.95A 2rlcA-5uprA:
undetectable
2rlcA-5uprA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vwn TRIOSEPHOSPHATE
ISOMERASE


(Trichomonas
vaginalis)
no annotation 5 ILE A 238
PHE A 224
ALA A 216
ASN A 240
ASN A  35
None
1.07A 2rlcA-5vwnA:
undetectable
2rlcA-5vwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)


(Lachnospiraceae
bacterium
NK4A179)
no annotation 5 PHE A1259
PHE A1365
ALA A1112
ILE A1361
ILE A1327
None
1.18A 2rlcA-5wlhA:
undetectable
2rlcA-5wlhA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wls POLLEN RECEPTOR-LIKE
KINASE 3


(Arabidopsis
thaliana)
no annotation 5 ILE A  60
PHE A 110
ILE A  84
ILE A  82
LEU A  29
None
1.02A 2rlcA-5wlsA:
undetectable
2rlcA-5wlsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT


(Komagataella
phaffii)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
5 PHE A 800
THR A 722
ALA A 726
ILE A 694
ILE A 695
None
0.93A 2rlcA-5xogA:
undetectable
2rlcA-5xogA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z95 -

(-)
no annotation 5 ILE A  80
PHE A  62
ALA A   7
ILE A 185
ILE A 189
None
1.14A 2rlcA-5z95A:
undetectable
2rlcA-5z95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bka NITRONATE
MONOOXYGENASE


(Cyberlindnera
mrakii)
no annotation 5 PHE A 176
ALA A 238
ILE A 220
ILE A 224
LEU A 250
None
FMN  A 401 ( 4.0A)
None
None
None
1.09A 2rlcA-6bkaA:
undetectable
2rlcA-6bkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byq TYROSINE--TRNA
LIGASE


(Helicobacter
pylori)
no annotation 5 ILE A  60
PHE A  45
PHE A 126
ALA A  43
THR A 122
None
1.12A 2rlcA-6byqA:
undetectable
2rlcA-6byqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d43 TRIOSEPHOSPHATE
ISOMERASE


(Homo sapiens)
no annotation 5 ILE B 243
PHE B 229
ALA B 221
ASN B 245
THR B  37
None
0.96A 2rlcA-6d43B:
undetectable
2rlcA-6d43B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dku VP35

(Myotis
lucifugus)
no annotation 5 PHE A 228
ALA A 200
ILE A 219
ILE A 281
LEU A 169
None
1.11A 2rlcA-6dkuA:
undetectable
2rlcA-6dkuA:
undetectable