SIMILAR PATTERNS OF AMINO ACIDS FOR 2RKF_A_AB1A501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

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	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1czi	CHYMOSIN (Bos taurus)	PF00026 (Asp)	5	LEU E 30 ASP E 32 GLY E 34 ASP E 37 ILE E 120	None	0.56A	2rkfA-1cziE: 6.9	2rkfA-1cziE: 17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1fft	UBIQUINOL OXIDASE (Escherichia coli)	PF00115 (COX1) PF00116 (COX2) PF06481 (COX_ARM)	5	ALA B 104 ILE A 354 GLY A 349 ALA A 356 ILE B 100	None None None HEO A1002 (-3.3A) HEO A1002 (-4.4A)	0.86A	2rkfA-1fftB: undetectable	2rkfA-1fftB: 16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1h74	HOMOSERINE KINASE (Methanocaldococcus jannaschii)	PF00288 (GHMP_kinases_N) PF08544 (GHMP_kinases_C)	5	LEU A 112 GLY A 80 GLY A 65 ALA A 108 ILE A 109	None	0.91A	2rkfA-1h74A: undetectable	2rkfA-1h74A: 15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1h7w	DIHYDROPYRIMIDINE DEHYDROGENASE (Sus scrofa)	PF01180 (DHO_dh) PF07992 (Pyr_redox_2) PF14691 (Fer4_20) PF14697 (Fer4_21)	5	ALA A 72 ILE A 101 GLY A 153 ALA A 112 ILE A 104	None None SF4 A1026 ( 3.9A) None None	0.85A	2rkfA-1h7wA: undetectable	2rkfA-1h7wA: 7.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 ALA A 22	A79 A 800 (-2.8A) A79 A 800 (-3.0A) A79 A 800 (-3.2A) A79 A 800 (-2.7A) A79 A 800 ( 4.7A) None	1.40A	2rkfA-1hvcA: 13.9	2rkfA-1hvcA: 43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 ILE A 50 ILE A 84	A79 A 800 ( 3.8A) A79 A 800 (-2.7A) A79 A 800 (-3.0A) A79 A 800 (-3.1A) A79 A 800 (-2.8A) A79 A 800 ( 4.9A) A79 A 800 ( 3.7A) A79 A 800 (-3.8A) A79 A 800 (-3.6A)	0.37A	2rkfA-1hvcA: 13.9	2rkfA-1hvcA: 43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	10	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 ILE A 50 PRO A 81 ILE A 84	A79 A 800 ( 4.0A) A79 A 800 (-2.8A) A79 A 800 (-3.0A) A79 A 800 (-3.2A) A79 A 800 (-2.7A) A79 A 800 ( 4.7A) A79 A 800 (-3.4A) A79 A 800 ( 4.0A) A79 A 800 ( 3.4A) A79 A 800 (-3.8A)	0.40A	2rkfA-1hvcA: 13.9	2rkfA-1hvcA: 43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	8	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 PRO A 81 ILE A 84	A79 A 800 ( 3.8A) A79 A 800 (-2.7A) A79 A 800 (-3.0A) A79 A 800 (-3.1A) A79 A 800 (-2.8A) A79 A 800 ( 4.9A) A79 A 800 ( 3.9A) A79 A 800 (-3.6A)	0.51A	2rkfA-1hvcA: 13.9	2rkfA-1hvcA: 43.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1idt	MINOR FMN-DEPENDENT NITROREDUCTASE (Escherichia coli)	PF00881 (Nitroreductase)	5	GLY A 66 ALA A 65 GLY A 166 ALA A 170 ILE A 171	None None FMN A1218 (-3.6A) None None	0.90A	2rkfA-1idtA: undetectable	2rkfA-1idtA: 22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1kbl	PYRUVATE PHOSPHATE DIKINASE ([Clostridium] symbiosum)	PF00391 (PEP-utilizers) PF01326 (PPDK_N) PF02896 (PEP-utilizers_C)	5	LEU A 426 ALA A 456 GLY A 462 ALA A 442 ILE A 445	None	0.90A	2rkfA-1kblA: undetectable	2rkfA-1kblA: 8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1kz1	6,7-DIMETHYL-8-RIBIT YLLUMAZINE SYNTHASE (Schizosaccharomyces pombe)	PF00885 (DMRL_synthase)	5	GLY A 147 ALA A 150 GLY A 83 ILE A 84 ILE A 20	None	0.92A	2rkfA-1kz1A: undetectable	2rkfA-1kz1A: 24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1mpp	PEPSIN (Rhizomucor pusillus)	PF00026 (Asp)	5	ASP A 215 GLY A 217 ILE A 222 GLY A 76 ILE A 300	None	0.84A	2rkfA-1mppA: 7.3	2rkfA-1mppA: 13.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1q9p	HIV-1 PROTEASE (Homo sapiens)	PF00077 (RVP)	6	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 ILE A 84	None	0.48A	2rkfA-1q9pA: 10.5	2rkfA-1q9pA: 82.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1siv	SIV PROTEASE (Simian immunodeficiency virus)	PF00077 (RVP)	5	GLY A 27 ALA A 28 ILE A 32 GLY A 48 ILE A 84	None	0.68A	2rkfA-1sivA: 18.6	2rkfA-1sivA: 51.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1siv	SIV PROTEASE (Simian immunodeficiency virus)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 ASP A 29 GLY A 49 ILE A 50	None	1.27A	2rkfA-1sivA: 18.6	2rkfA-1sivA: 51.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1siv	SIV PROTEASE (Simian immunodeficiency virus)	PF00077 (RVP)	11	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 ILE A 32 GLY A 49 ILE A 50 PRO A 81 ILE A 84	None	0.51A	2rkfA-1sivA: 18.6	2rkfA-1sivA: 51.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1to3	PUTATIVE ALDOLASE YIHT (Salmonella enterica)	PF01791 (DeoC)	5	LEU A 184 GLY A 188 ALA A 189 ASP A 190 ILE A 158	None	0.78A	2rkfA-1to3A: undetectable	2rkfA-1to3A: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1up2	CELA1 PROTEIN (Mycobacterium tuberculosis)	PF01341 (Glyco_hydro_6)	5	GLY A 246 ALA A 245 ILE A 302 ALA A 290 ILE A 291	None	0.88A	2rkfA-1up2A: undetectable	2rkfA-1up2A: 15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1y7w	HALOTOLERANT ALPHA-TYPE CARBONIC ANHYDRASE (DCA II) (Dunaliella salina)	PF00194 (Carb_anhydrase)	5	GLY A 211 ALA A 210 ILE A 125 GLY A 155 ILE A 41	None	0.71A	2rkfA-1y7wA: undetectable	2rkfA-1y7wA: 17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1zap	SECRETED ASPARTIC PROTEINASE (Candida albicans)	PF00026 (Asp)	5	LEU A 216 ASP A 218 GLY A 220 ALA A 303 ILE A 305	None A70 A 500 ( 2.3A) A70 A 500 (-3.3A) A70 A 500 ( 3.8A) A70 A 500 (-4.8A)	0.75A	2rkfA-1zapA: 7.3	2rkfA-1zapA: 14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2bb3	COBALAMIN BIOSYNTHESIS PRECORRIN-6Y METHYLASE (CBIE) (Archaeoglobus fulgidus)	PF00590 (TP_methylase)	5	GLY A 39 ALA A 38 GLY A 30 ALA A 25 ILE A 22	None	0.89A	2rkfA-2bb3A: undetectable	2rkfA-2bb3A: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2bc0	NADH OXIDASE (Streptococcus pyogenes)	PF02852 (Pyr_redox_dim) PF07992 (Pyr_redox_2)	5	GLY A 453 ALA A 454 ASP A 456 ILE A 387 ILE A 426	None	0.60A	2rkfA-2bc0A: undetectable	2rkfA-2bc0A: 12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2f31	DIAPHANOUS PROTEIN HOMOLOG 1 (Mus musculus)	PF06367 (Drf_FH3) PF06371 (Drf_GBD)	5	ALA A 238 ILE A 208 GLY A 231 ILE A 232 ILE A 209	None	0.79A	2rkfA-2f31A: undetectable	2rkfA-2f31A: 18.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2fmb	EQUINE INFECTIOUS ANEMIA VIRUS PROTEASE (Equine infectious anemia virus)	PF00077 (RVP)	8	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 29 GLY A 55 PRO A 86 ILE A 89	None LP1 A 201 (-2.3A) LP1 A 201 (-3.8A) LP1 A 201 (-3.5A) LP1 A 201 (-3.6A) LP1 A 201 (-3.4A) LP1 A 201 (-3.9A) LP1 A 201 (-4.2A)	0.41A	2rkfA-2fmbA: 15.1	2rkfA-2fmbA: 30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2hpg	ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN (Thermotoga maritima)	PF03480 (DctP)	5	LEU A 123 GLY A 272 ILE A 279 ALA A 119 ILE A 120	None	0.72A	2rkfA-2hpgA: undetectable	2rkfA-2hpgA: 14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2rgj	FLAVIN-CONTAINING MONOOXYGENASE (Pseudomonas aeruginosa)	PF01494 (FAD_binding_3)	5	LEU A 175 ALA A 311 ASP A 310 GLY A 11 ILE A 9	None None FAD A 403 (-2.7A) FAD A 403 (-3.2A) None	0.92A	2rkfA-2rgjA: undetectable	2rkfA-2rgjA: 16.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2rsp	RSV PROTEASE (Rous sarcoma virus)	PF00077 (RVP)	7	LEU A 35 ASP A 37 GLY A 39 ALA A 40 ASP A 41 ILE A 44 ILE A 108	None	0.38A	2rkfA-2rspA: 13.0	2rkfA-2rspA: 30.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2wsk	GLYCOGEN DEBRANCHING ENZYME (Escherichia coli)	PF00128 (Alpha-amylase) PF02922 (CBM_48)	5	LEU A 188 GLY A 255 ALA A 254 ILE A 248 ILE A 185	None	0.78A	2rkfA-2wskA: undetectable	2rkfA-2wskA: 9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2x2g	TRIOSEPHOSPHATE ISOMERASE, GLYCOSOMAL (Trypanosoma brucei)	PF00121 (TIM)	5	ALA A 125 ILE A 147 GLY A 128 ALA A 149 ILE A 150	None	0.88A	2rkfA-2x2gA: undetectable	2rkfA-2x2gA: 20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2yjn	DTDP-4-KETO-6-DEOXY- HEXOSE 3,4-ISOMERASE (Saccharopolyspora erythraea)	PF00067 (p450)	5	LEU B 39 GLY B 113 ALA B 114 GLY B 30 ILE B 36	None	0.91A	2rkfA-2yjnB: undetectable	2rkfA-2yjnB: 15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3dbg	PUTATIVE CYTOCHROME P450 (Streptomyces coelicolor)	PF00067 (p450)	5	GLY A 359 ALA A 360 ASP A 361 PRO A 24 ILE A 356	None	0.87A	2rkfA-3dbgA: undetectable	2rkfA-3dbgA: 12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3e4e	CYTOCHROME P450 2E1 (Homo sapiens)	PF00067 (p450)	5	ALA A 438 ILE A 115 GLY A 300 ILE A 180 ILE A 114	HEM A 500 (-3.8A) HEM A 500 (-4.0A) HEM A 500 (-3.4A) None HEM A 500 (-4.0A)	0.79A	2rkfA-3e4eA: undetectable	2rkfA-3e4eA: 11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3frv	CHARGED MULTIVESICULAR BODY PROTEIN 3 (Homo sapiens)	PF03357 (Snf7)	5	LEU A 104 GLY A 90 ILE A 140 ALA A 137 ILE A 139	None	0.84A	2rkfA-3frvA: undetectable	2rkfA-3frvA: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3gve	YFKN PROTEIN (Bacillus subtilis)	PF00149 (Metallophos)	5	GLY A 121 ALA A 122 ASP A 123 ILE A 89 ILE A 126	None	0.73A	2rkfA-3gveA: undetectable	2rkfA-3gveA: 15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3hkz	DNA-DIRECTED RNA POLYMERASE SUBUNIT A' (Sulfolobus solfataricus)	PF00623 (RNA_pol_Rpb1_2) PF04983 (RNA_pol_Rpb1_3) PF04997 (RNA_pol_Rpb1_1) PF04998 (RNA_pol_Rpb1_5) PF05000 (RNA_pol_Rpb1_4)	5	GLY A 712 ALA A 711 ILE A 665 GLY A 748 ILE A 661	None	0.91A	2rkfA-3hkzA: undetectable	2rkfA-3hkzA: 9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3k2w	BETAINE-ALDEHYDE DEHYDROGENASE (Pseudoalteromonas atlantica)	PF00171 (Aldedh)	5	LEU A 76 GLY A 200 ALA A 199 ILE A 83 GLY A 193	None	0.87A	2rkfA-3k2wA: undetectable	2rkfA-3k2wA: 13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3keh	GLUCOCEREBROSIDASE (Homo sapiens)	PF02055 (Glyco_hydro_30) PF17189 (Glyco_hydro_30C)	5	ALA A 232 GLY A 307 ILE A 308 ALA A 301 ILE A 260	None	0.82A	2rkfA-3kehA: undetectable	2rkfA-3kehA: 12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3khz	PUTATIVE DIPEPTIDASE SACOL1801 (Staphylococcus aureus)	PF01546 (Peptidase_M20)	6	LEU A 130 GLY A 73 ALA A 72 GLY A 80 ALA A 126 ILE A 127	None	0.94A	2rkfA-3khzA: undetectable	2rkfA-3khzA: 12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3l49	ABC SUGAR (RIBOSE) TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING SUBUNIT (Rhodobacter sphaeroides)	PF13407 (Peripla_BP_4)	5	LEU A 105 ILE A 113 GLY A 35 ILE A 36 ILE A 108	None	0.82A	2rkfA-3l49A: undetectable	2rkfA-3l49A: 16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3mwe	ATP-CITRATE SYNTHASE (Homo sapiens)	PF16114 (Citrate_bind)	5	LEU A 301 GLY A 296 ILE A 337 GLY A 416 ILE A 275	None	0.86A	2rkfA-3mweA: undetectable	2rkfA-3mweA: 13.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mws	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 ASP A 29 GLY A 49 ILE A 50	None	1.25A	2rkfA-3mwsA: 19.6	2rkfA-3mwsA: 70.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mws	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	8	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 PRO A 81 ILE A 84	None	0.49A	2rkfA-3mwsA: 19.6	2rkfA-3mwsA: 70.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mws	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 29 GLY A 49 ILE A 50 PRO A 81 ILE A 84	None	0.34A	2rkfA-3mwsA: 19.6	2rkfA-3mwsA: 70.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3one	ADENOSYLHOMOCYSTEINA SE (Lupinus luteus)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	5	GLY A 269 ALA A 268 ILE A 331 ILE A 348 ILE A 330	NAD A 501 (-3.6A) NAD A 501 ( 4.8A) None NAD A 501 (-4.4A) NAD A 501 (-4.8A)	0.88A	2rkfA-3oneA: undetectable	2rkfA-3oneA: 13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3pqv	RCL1 PROTEIN (Kluyveromyces lactis)	PF01137 (RTC) PF05189 (RTC_insert)	5	LEU A 136 ALA A 99 ILE A 129 ALA A 131 ILE A 132	None	0.83A	2rkfA-3pqvA: undetectable	2rkfA-3pqvA: 15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3slz	GAG-PRO-POL POLYPROTEIN (Murine leukemia virus)	PF00077 (RVP)	5	LEU A 30 ASP A 32 GLY A 34 ALA A 35 GLY A 56	None 3TL A 126 (-2.4A) 3TL A 126 (-3.1A) 3TL A 126 ( 4.0A) 3TL A 126 (-3.4A)	0.34A	2rkfA-3slzA: 11.3	2rkfA-3slzA: 25.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3t3c	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 ILE A 50 ALA A 82	SO4 A 101 (-4.2A) 017 A 201 (-2.6A) 017 A 201 (-3.4A) 017 A 201 (-3.5A) 017 A 201 (-3.5A) 017 A 201 (-4.2A) 017 A 201 (-4.0A) 017 A 201 (-3.3A) SO4 A 101 (-3.5A)	0.53A	2rkfA-3t3cA: 18.4	2rkfA-3t3cA: 72.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3t3c	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 PRO A 81 ALA A 82	SO4 A 101 (-4.2A) 017 A 201 (-2.6A) 017 A 201 (-3.4A) 017 A 201 (-3.5A) 017 A 201 (-3.5A) 017 A 201 (-4.2A) 017 A 201 (-4.0A) None SO4 A 101 (-3.5A)	0.64A	2rkfA-3t3cA: 18.4	2rkfA-3t3cA: 72.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ttp	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 ALA A 22	017 A 201 (-2.6A) 017 A 201 (-3.6A) 017 A 201 (-3.4A) 017 A 201 (-3.3A) 017 A 201 (-4.6A) None	1.32A	2rkfA-3ttpA: 19.9	2rkfA-3ttpA: 81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ttp	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	11	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 ILE A 32 GLY A 49 ILE A 50 PRO A 81 ILE A 84	None 017 A 201 (-2.6A) 017 A 201 (-3.6A) 017 A 201 (-3.4A) 017 A 201 (-3.3A) 017 A 201 (-4.6A) None 017 A 201 (-3.0A) 017 A 201 (-3.3A) 017 A 201 (-4.1A) 017 A 201 (-4.7A)	0.40A	2rkfA-3ttpA: 19.9	2rkfA-3ttpA: 81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3u7s	POL POLYPROTEIN (Human immunodeficiency virus 1)	PF00077 (RVP)	6	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 ALA A 22	017 A 202 ( 2.5A) 017 A 201 ( 3.5A) 017 A 201 (-3.4A) 017 A 201 (-3.2A) 017 A 201 ( 4.0A) None	1.36A	2rkfA-3u7sA: 20.2	2rkfA-3u7sA: 79.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3u7s	POL POLYPROTEIN (Human immunodeficiency virus 1)	PF00077 (RVP)	10	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 ILE A 32 GLY A 49 ILE A 50 PRO A 81	None 017 A 202 ( 2.5A) 017 A 201 ( 3.5A) 017 A 201 (-3.4A) 017 A 201 (-3.2A) 017 A 201 ( 4.0A) None 017 A 202 (-2.9A) 017 A 201 ( 3.5A) 017 A 202 (-4.0A)	0.43A	2rkfA-3u7sA: 20.2	2rkfA-3u7sA: 79.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3uhl	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	7	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 29 ILE A 32 PRO A 81	None	0.48A	2rkfA-3uhlA: 16.1	2rkfA-3uhlA: 76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3vas	PUTATIVE ADENOSINE KINASE (Schistosoma mansoni)	PF00294 (PfkB)	5	ILE A 73 GLY A 11 ILE A 166 ALA A 305 ILE A 309	None	0.88A	2rkfA-3vasA: undetectable	2rkfA-3vasA: 13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3wbn	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus furiosus)	PF01554 (MatE)	5	LEU A 122 ALA A 140 ILE A 111 ALA A 118 ILE A 119	None	0.69A	2rkfA-3wbnA: undetectable	2rkfA-3wbnA: 13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3zq4	RIBONUCLEASE J 1 (Bacillus subtilis)	PF00753 (Lactamase_B) PF07521 (RMMBL)	5	LEU A 86 ILE A 80 GLY A 96 ALA A 38 ILE A 83	None	0.79A	2rkfA-3zq4A: undetectable	2rkfA-3zq4A: 11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4cw5	DFNA (Bacillus velezensis)	PF03060 (NMO)	5	GLY A 559 GLY A 732 ILE A 731 PRO A 542 ILE A 539	FMN A1753 (-3.0A) None None None None	0.90A	2rkfA-4cw5A: undetectable	2rkfA-4cw5A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4e3w	ACID PHOSPHATASE (Francisella tularensis)	PF00328 (His_Phos_2)	5	ALA A 211 ASP A 207 GLY A 184 ILE A 181 ALA A 159	None	0.91A	2rkfA-4e3wA: undetectable	2rkfA-4e3wA: 14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4gmk	RIBOSE-5-PHOSPHATE ISOMERASE A (Lactobacillus salivarius)	PF06026 (Rib_5-P_isom_A)	5	GLY A 100 ALA A 101 GLY A 204 ILE A 96 ILE A 176	PO4 A 301 (-3.6A) None None None None	0.91A	2rkfA-4gmkA: undetectable	2rkfA-4gmkA: 18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4h6q	PROLINE DEHYDROGENASE (Deinococcus radiodurans)	PF01619 (Pro_dh)	5	GLY A 90 ALA A 89 ILE A 83 ALA A 43 ILE A 44	None	0.76A	2rkfA-4h6qA: undetectable	2rkfA-4h6qA: 16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4hdj	OUTER MEMBRANE PROTEIN ASSEMBLY FACTOR BAMB (Pseudomonas aeruginosa)	PF13360 (PQQ_2)	5	ASP A 207 GLY A 160 ILE A 159 PRO A 187 ALA A 196	None	0.71A	2rkfA-4hdjA: undetectable	2rkfA-4hdjA: 13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ida	RIPENING-INDUCED PROTEIN (Fragaria vesca)	PF08240 (ADH_N) PF13602 (ADH_zinc_N_2)	5	GLY A 208 ALA A 209 ASP A 210 ILE A 179 ALA A 196	None None None None SO4 A 402 (-3.3A)	0.89A	2rkfA-4idaA: undetectable	2rkfA-4idaA: 18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ida	RIPENING-INDUCED PROTEIN (Fragaria vesca)	PF08240 (ADH_N) PF13602 (ADH_zinc_N_2)	5	LEU A 203 GLY A 208 ALA A 209 ASP A 210 ILE A 179	None	0.87A	2rkfA-4idaA: undetectable	2rkfA-4idaA: 18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4j8l	UNCHARACTERIZED PROTEIN YHFS (Escherichia coli)	PF00155 (Aminotran_1_2)	5	LEU A 59 ALA A 65 ASP A 209 GLY A 182 ALA A 205	None	0.90A	2rkfA-4j8lA: undetectable	2rkfA-4j8lA: 15.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4njv	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	5	ALA A 28 ASP A 29 ASP A 30 GLY A 48 ILE A 84	RIT A 500 (-3.6A) RIT A 500 (-3.2A) RIT A 500 (-4.8A) RIT A 500 (-4.8A) RIT A 500 (-4.3A)	0.72A	2rkfA-4njvA: 20.6	2rkfA-4njvA: 80.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4njv	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	8	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 PRO A 81 ILE A 84	None RIT A 500 (-2.4A) RIT A 500 (-3.9A) RIT A 500 (-3.6A) RIT A 500 (-3.2A) RIT A 500 (-4.8A) RIT A 500 (-3.9A) RIT A 500 (-4.3A)	0.44A	2rkfA-4njvA: 20.6	2rkfA-4njvA: 80.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4njv	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 29 GLY A 49 ILE A 50 PRO A 81 ILE A 84	None RIT A 500 (-2.4A) RIT A 500 (-3.9A) RIT A 500 (-3.6A) RIT A 500 (-3.2A) RIT A 500 (-3.4A) RIT A 500 (-4.3A) RIT A 500 (-3.9A) RIT A 500 (-4.3A)	0.38A	2rkfA-4njvA: 20.6	2rkfA-4njvA: 80.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4o89	RNA 3'-TERMINAL PHOSPHATE CYCLASE (Pyrococcus horikoshii)	PF01137 (RTC) PF05189 (RTC_insert)	5	GLY A 296 ILE A 145 ILE A 289 ALA A 139 ILE A 143	None	0.78A	2rkfA-4o89A: undetectable	2rkfA-4o89A: 17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4rgh	PROTEIN DDI1 HOMOLOG 2 (Homo sapiens)	PF09668 (Asp_protease)	5	ASP A 220 GLY A 222 ALA A 223 ILE A 227 GLY A 252	None	0.85A	2rkfA-4rghA: 10.6	2rkfA-4rghA: 20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4rgh	PROTEIN DDI1 HOMOLOG 2 (Homo sapiens)	PF09668 (Asp_protease)	5	ASP A 220 GLY A 222 ALA A 223 ILE A 227 PRO A 285	None	0.61A	2rkfA-4rghA: 10.6	2rkfA-4rghA: 20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4tnb	G PROTEIN-COUPLED RECEPTOR KINASE 5 (Homo sapiens)	PF00069 (Pkinase) PF00615 (RGS)	5	LEU A 45 ASP A 52 GLY A 63 ILE A 62 ILE A 49	None	0.85A	2rkfA-4tnbA: undetectable	2rkfA-4tnbA: 11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ttp	DEPHOSPHO-COA KINASE (Legionella pneumophila)	PF01121 (CoaE)	5	LEU A 168 ALA A 175 ASP A 176 ASP A 177 ILE A 118	None	0.86A	2rkfA-4ttpA: undetectable	2rkfA-4ttpA: 18.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ydf	HTLV-1 PROTEASE (Primate T-lymphotropic virus 1)	PF00077 (RVP)	7	LEU A 30 ASP A 32 GLY A 34 ALA A 35 ASP A 36 GLY A 58 ILE A 100	None 4B1 A 201 (-2.9A) 4B1 A 201 ( 4.6A) 4B1 A 201 (-3.6A) 4B1 A 201 (-4.4A) 4B1 A 201 (-3.4A) 4B1 A 201 (-4.8A)	0.39A	2rkfA-4ydfA: 13.2	2rkfA-4ydfA: 34.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5b0h	LEUKOCYTE CELL-DERIVED CHEMOTAXIN-2 (Homo sapiens)	PF01551 (Peptidase_M23)	5	GLY A 99 ALA A 50 ILE A 56 GLY A 103 ILE A 96	None	0.85A	2rkfA-5b0hA: undetectable	2rkfA-5b0hA: 18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5b18	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	7	GLY A 27 ALA A 28 ASP A 29 ASP A 30 ILE A 32 PRO A 81 ILE A 84	None	0.49A	2rkfA-5b18A: 17.9	2rkfA-5b18A: 74.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5b18	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	5	GLY A 27 ALA A 28 ASP A 29 GLY A 49 ILE A 84	None	0.69A	2rkfA-5b18A: 17.9	2rkfA-5b18A: 74.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5c04	PUTATIVE PEROXIREDOXIN MT2298 (Mycobacterium tuberculosis)	PF00578 (AhpC-TSA)	5	ALA A 130 GLY A 105 PRO A 9 ALA A 8 ILE A 127	None	0.87A	2rkfA-5c04A: undetectable	2rkfA-5c04A: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5cio	PYRROLOQUINOLINE QUINONE BIOSYNTHESIS PROTEIN PQQF (Serratia sp. FS14)	PF00675 (Peptidase_M16) PF05193 (Peptidase_M16_C)	5	LEU A 554 ALA A 681 GLY A 662 ALA A 550 ILE A 551	None	0.89A	2rkfA-5cioA: undetectable	2rkfA-5cioA: 9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5cw2	PUTATIVE EPOXIDE HYDROLASE EPHA (Mycolicibacterium thermoresistibile)	no annotation	5	LEU C 315 GLY C 53 ALA C 52 ILE C 46 ILE C 312	None	0.80A	2rkfA-5cw2C: undetectable	2rkfA-5cw2C: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5e31	PENICILLIN BINDING PROTEIN 2 PRIME (Enterococcus faecium)	PF00905 (Transpeptidase) PF03717 (PBP_dimer) PF05223 (MecA_N)	5	LEU A 184 GLY A 276 ILE A 343 ILE A 514 ILE A 176	None	0.87A	2rkfA-5e31A: undetectable	2rkfA-5e31A: 9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5gan	PRE-MRNA-PROCESSING FACTOR 31 (Saccharomyces cerevisiae)	PF01798 (Nop) PF09785 (Prp31_C)	5	GLY F 247 ILE F 222 GLY F 215 ILE F 214 ILE F 225	None	0.70A	2rkfA-5ganF: undetectable	2rkfA-5ganF: 11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5il5	MLND (Bacillus velezensis)	PF14765 (PS-DH)	5	GLY A1310 ALA A1309 ILE A1278 ILE A1303 ILE A1341	None	0.69A	2rkfA-5il5A: undetectable	2rkfA-5il5A: 16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5irp	ALANINE RACEMASE 2 (Bacillus subtilis)	PF00842 (Ala_racemase_C) PF01168 (Ala_racemase_N)	5	GLY A 77 ALA A 76 GLY A 70 ILE A 82 ILE A 48	None	0.87A	2rkfA-5irpA: undetectable	2rkfA-5irpA: 13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ldn	HEXON PROTEIN,HEXON CAPSID (Human mastadenovirus C)	PF01065 (Adeno_hexon) PF03678 (Adeno_hexon_C)	5	GLY A 220 ALA A 171 ILE A 215 GLY A 206 ILE A 205	None	0.78A	2rkfA-5ldnA: undetectable	2rkfA-5ldnA: 8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5nd1	CAPSID PROTEIN (Rosellinia necatrix quadrivirus 1)	no annotation	5	GLY A 778 ALA A 779 ILE A 787 ALA A 809 ILE A 805	None	0.89A	2rkfA-5nd1A: undetectable	2rkfA-5nd1A: 19.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5t2z	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 ALA A 22	None	1.32A	2rkfA-5t2zA: 20.6	2rkfA-5t2zA: 75.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5t2z	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 ASP A 29 GLY A 49 ILE A 50	None	1.23A	2rkfA-5t2zA: 20.6	2rkfA-5t2zA: 75.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5t2z	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	10	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 ILE A 50 PRO A 81 ILE A 84	None	0.39A	2rkfA-5t2zA: 20.6	2rkfA-5t2zA: 75.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5tus	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE LARGE SUBUNIT (Homo sapiens)	PF00317 (Ribonuc_red_lgN) PF02867 (Ribonuc_red_lgC) PF03477 (ATP-cone)	5	GLY A 538 ALA A 539 ILE A 501 ALA A 447 ILE A 503	None	0.83A	2rkfA-5tusA: undetectable	2rkfA-5tusA: 9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5w4b	ADENOSYLHOMOCYSTEINA SE (Homo sapiens)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	5	GLY A 220 ALA A 219 ILE A 282 ILE A 299 ILE A 281	NAD A 501 ( 3.7A) None None NAD A 501 (-4.3A) NAD A 501 (-4.8A)	0.85A	2rkfA-5w4bA: undetectable	2rkfA-5w4bA: 14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5xhw	PUTATIVE 6-DEOXY-D-MANNOHEPTO SE PATHWAY PROTEIN (Yersinia pseudotuberculosis)	no annotation	5	LEU A 113 GLY A 168 ASP A 210 ILE A 164 ALA A 206	None	0.87A	2rkfA-5xhwA: undetectable	2rkfA-5xhwA: 23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5xj1	UNCHARACTERIZED RNA METHYLTRANSFERASE SP_1029 (Streptococcus pneumoniae)	no annotation	6	GLY A 399 ALA A 400 ASP A 401 ILE A 373 ALA A 311 ILE A 378	None	0.97A	2rkfA-5xj1A: undetectable	2rkfA-5xj1A: 13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5xoz	TRYPSIN PROTEIN INHIBITOR 2 (Cicer arietinum)	no annotation	5	GLY A 133 ILE A 117 GLY A 149 ALA A 115 ILE A 106	None	0.79A	2rkfA-5xozA: undetectable	2rkfA-5xozA: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5zgb	PSAL (Cyanidioschyzon merolae)	no annotation	5	LEU L 89 GLY L 51 ALA L 125 ILE L 83 ILE L 86	BCR L 205 (-3.7A) None None None None	0.81A	2rkfA-5zgbL: undetectable	2rkfA-5zgbL: 23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6ehi	NUCLEASE NUCT (Helicobacter pylori)	no annotation	5	ALA A 24 ILE A 110 ILE A 18 ALA A 104 ILE A 106	None	0.92A	2rkfA-6ehiA: undetectable	2rkfA-6ehiA: 18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6fiv	RETROPEPSIN (Feline immunodeficiency virus)	PF00077 (RVP)	7	LEU A 28 ASP A 30 GLY A 32 ALA A 33 ASP A 34 ILE A 37 GLY A 58	None 3TL A 201 (-3.5A) 3TL A 201 (-3.4A) 3TL A 201 (-4.0A) 3TL A 201 (-3.9A) 3TL A 201 ( 4.8A) 3TL A 201 (-3.4A)	0.39A	2rkfA-6fivA: 15.6	2rkfA-6fivA: 28.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6upj	HIV-2 PROTEASE (Human immunodeficiency virus 2)	PF00077 (RVP)	10	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 ILE A 32 GLY A 49 PRO A 81 ILE A 84	None NIU A 100 (-2.8A) NIU A 100 (-4.5A) NIU A 100 (-3.6A) None None None NIU A 100 ( 3.8A) None None	0.61A	2rkfA-6upjA: 18.2	2rkfA-6upjA: 49.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6upj	HIV-2 PROTEASE (Human immunodeficiency virus 2)	PF00077 (RVP)	10	LEU A 23 ASP A 25 GLY A 27 ASP A 29 ASP A 30 ILE A 32 GLY A 49 ILE A 50 PRO A 81 ILE A 84	None NIU A 100 (-2.8A) NIU A 100 (-4.5A) None None None NIU A 100 ( 3.8A) NIU A 100 (-3.9A) None None	0.66A	2rkfA-6upjA: 18.2	2rkfA-6upjA: 49.49

[["2RKF_A_AB1A501_1","1czi","Bos taurus","CHYMOSIN","PF00026(Asp)",5,"LEU E  30;ASP E  32;GLY E  34;ASP E  37;ILE E 120","None","0.56A","2rkfA-1cziE:6.9","2rkfA-1cziE:17.01"],["2RKF_A_AB1A501_1","1fft","Escherichia coli","UBIQUINOL OXIDASE","PF00115(COX1);PF00116(COX2);PF06481(COX_ARM)",5,"ALA B 104;ILE A 354;GLY A 349;ALA A 356;ILE B 100","None;None;None;HEO A1002 (-3.3A);HEO A1002 (-4.4A)","0.86A","2rkfA-1fftB:undetectable","2rkfA-1fftB:16.43"],["2RKF_A_AB1A501_1","1h74","Methanocaldococcus jannaschii","HOMOSERINE KINASE","PF00288(GHMP_kinases_N);PF08544(GHMP_kinases_C)",5,"LEU A 112;GLY A  80;GLY A  65;ALA A 108;ILE A 109","None","0.91A","2rkfA-1h74A:undetectable","2rkfA-1h74A:15.59"],["2RKF_A_AB1A501_1","1h7w","Sus scrofa","DIHYDROPYRIMIDINE DEHYDROGENASE","PF01180(DHO_dh);PF07992(Pyr_redox_2);PF14691(Fer4_20);PF14697(Fer4_21)",5,"ALA A  72;ILE A 101;GLY A 153;ALA A 112;ILE A 104","None;None;SF4 A1026 ( 3.9A);None;None","0.85A","2rkfA-1h7wA:undetectable","2rkfA-1h7wA:7.15"],["2RKF_A_AB1A501_1","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",6,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;ALA A  22","A79 A 800 (-2.8A);A79 A 800 (-3.0A);A79 A 800 (-3.2A);A79 A 800 (-2.7A);A79 A 800 ( 4.7A);None","1.40A","2rkfA-1hvcA:13.9","2rkfA-1hvcA:43.35"],["2RKF_A_AB1A501_1","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",9,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;ILE A  50;ILE A  84","A79 A 800 ( 3.8A);A79 A 800 (-2.7A);A79 A 800 (-3.0A);A79 A 800 (-3.1A);A79 A 800 (-2.8A);A79 A 800 ( 4.9A);A79 A 800 ( 3.7A);A79 A 800 (-3.8A);A79 A 800 (-3.6A)","0.37A","2rkfA-1hvcA:13.9","2rkfA-1hvcA:43.35"],["2RKF_A_AB1A501_1","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",10,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;ILE A  50;PRO A  81;ILE A  84","A79 A 800 ( 4.0A);A79 A 800 (-2.8A);A79 A 800 (-3.0A);A79 A 800 (-3.2A);A79 A 800 (-2.7A);A79 A 800 ( 4.7A);A79 A 800 (-3.4A);A79 A 800 ( 4.0A);A79 A 800 ( 3.4A);A79 A 800 (-3.8A)","0.40A","2rkfA-1hvcA:13.9","2rkfA-1hvcA:43.35"],["2RKF_A_AB1A501_1","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",8,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;PRO A  81;ILE A  84","A79 A 800 ( 3.8A);A79 A 800 (-2.7A);A79 A 800 (-3.0A);A79 A 800 (-3.1A);A79 A 800 (-2.8A);A79 A 800 ( 4.9A);A79 A 800 ( 3.9A);A79 A 800 (-3.6A)","0.51A","2rkfA-1hvcA:13.9","2rkfA-1hvcA:43.35"],["2RKF_A_AB1A501_1","1idt","Escherichia coli","MINOR FMN-DEPENDENT NITROREDUCTASE","PF00881(Nitroreductase)",5,"GLY A  66;ALA A  65;GLY A 166;ALA A 170;ILE A 171","None;None;FMN A1218 (-3.6A);None;None","0.90A","2rkfA-1idtA:undetectable","2rkfA-1idtA:22.11"],["2RKF_A_AB1A501_1","1kbl","[Clostridium] symbiosum","PYRUVATE PHOSPHATE DIKINASE","PF00391(PEP-utilizers);PF01326(PPDK_N);PF02896(PEP-utilizers_C)",5,"LEU A 426;ALA A 456;GLY A 462;ALA A 442;ILE A 445","None","0.90A","2rkfA-1kblA:undetectable","2rkfA-1kblA:8.33"],["2RKF_A_AB1A501_1","1kz1","Schizosaccharomyces pombe","6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE","PF00885(DMRL_synthase)",5,"GLY A 147;ALA A 150;GLY A  83;ILE A  84;ILE A  20","None","0.92A","2rkfA-1kz1A:undetectable","2rkfA-1kz1A:24.00"],["2RKF_A_AB1A501_1","1mpp","Rhizomucor pusillus","PEPSIN","PF00026(Asp)",5,"ASP A 215;GLY A 217;ILE A 222;GLY A  76;ILE A 300","None","0.84A","2rkfA-1mppA:7.3","2rkfA-1mppA:13.57"],["2RKF_A_AB1A501_1","1q9p","Homo sapiens","HIV-1 PROTEASE","PF00077(RVP)",6,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;ILE A  84","None","0.48A","2rkfA-1q9pA:10.5","2rkfA-1q9pA:82.11"],["2RKF_A_AB1A501_1","1siv","Simian immunodeficiency virus","SIV PROTEASE","PF00077(RVP)",5,"GLY A  27;ALA A  28;ILE A  32;GLY A  48;ILE A  84","None","0.68A","2rkfA-1sivA:18.6","2rkfA-1sivA:51.52"],["2RKF_A_AB1A501_1","1siv","Simian immunodeficiency virus","SIV PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;ASP A  29;GLY A  49;ILE A  50","None","1.27A","2rkfA-1sivA:18.6","2rkfA-1sivA:51.52"],["2RKF_A_AB1A501_1","1siv","Simian immunodeficiency virus","SIV PROTEASE","PF00077(RVP)",11,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;ILE A  32;GLY A  49;ILE A  50;PRO A  81;ILE A  84","None","0.51A","2rkfA-1sivA:18.6","2rkfA-1sivA:51.52"],["2RKF_A_AB1A501_1","1to3","Salmonella enterica","PUTATIVE ALDOLASE YIHT","PF01791(DeoC)",5,"LEU A 184;GLY A 188;ALA A 189;ASP A 190;ILE A 158","None","0.78A","2rkfA-1to3A:undetectable","2rkfA-1to3A:14.52"],["2RKF_A_AB1A501_1","1up2","Mycobacterium tuberculosis","CELA1 PROTEIN","PF01341(Glyco_hydro_6)",5,"GLY A 246;ALA A 245;ILE A 302;ALA A 290;ILE A 291","None","0.88A","2rkfA-1up2A:undetectable","2rkfA-1up2A:15.36"],["2RKF_A_AB1A501_1","1y7w","Dunaliella salina","HALOTOLERANT ALPHA-TYPE CARBONIC ANHYDRASE (DCA II)","PF00194(Carb_anhydrase)",5,"GLY A 211;ALA A 210;ILE A 125;GLY A 155;ILE A  41","None","0.71A","2rkfA-1y7wA:undetectable","2rkfA-1y7wA:17.53"],["2RKF_A_AB1A501_1","1zap","Candida albicans","SECRETED ASPARTIC PROTEINASE","PF00026(Asp)",5,"LEU A 216;ASP A 218;GLY A 220;ALA A 303;ILE A 305","None;A70 A 500 ( 2.3A);A70 A 500 (-3.3A);A70 A 500 ( 3.8A);A70 A 500 (-4.8A)","0.75A","2rkfA-1zapA:7.3","2rkfA-1zapA:14.46"],["2RKF_A_AB1A501_1","2bb3","Archaeoglobus fulgidus","COBALAMIN BIOSYNTHESIS PRECORRIN-6Y METHYLASE (CBIE)","PF00590(TP_methylase)",5,"GLY A  39;ALA A  38;GLY A  30;ALA A  25;ILE A  22","None","0.89A","2rkfA-2bb3A:undetectable","2rkfA-2bb3A:16.67"],["2RKF_A_AB1A501_1","2bc0","Streptococcus pyogenes","NADH OXIDASE","PF02852(Pyr_redox_dim);PF07992(Pyr_redox_2)",5,"GLY A 453;ALA A 454;ASP A 456;ILE A 387;ILE A 426","None","0.60A","2rkfA-2bc0A:undetectable","2rkfA-2bc0A:12.24"],["2RKF_A_AB1A501_1","2f31","Mus musculus","DIAPHANOUS PROTEIN HOMOLOG 1","PF06367(Drf_FH3);PF06371(Drf_GBD)",5,"ALA A 238;ILE A 208;GLY A 231;ILE A 232;ILE A 209","None","0.79A","2rkfA-2f31A:undetectable","2rkfA-2f31A:18.10"],["2RKF_A_AB1A501_1","2fmb","Equine infectious anemia virus","EQUINE INFECTIOUS ANEMIA VIRUS PROTEASE","PF00077(RVP)",8,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  29;GLY A  55;PRO A  86;ILE A  89","None;LP1 A 201 (-2.3A);LP1 A 201 (-3.8A);LP1 A 201 (-3.5A);LP1 A 201 (-3.6A);LP1 A 201 (-3.4A);LP1 A 201 (-3.9A);LP1 A 201 (-4.2A)","0.41A","2rkfA-2fmbA:15.1","2rkfA-2fmbA:30.77"],["2RKF_A_AB1A501_1","2hpg","Thermotoga maritima","ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN","PF03480(DctP)",5,"LEU A 123;GLY A 272;ILE A 279;ALA A 119;ILE A 120","None","0.72A","2rkfA-2hpgA:undetectable","2rkfA-2hpgA:14.01"],["2RKF_A_AB1A501_1","2rgj","Pseudomonas aeruginosa","FLAVIN-CONTAINING MONOOXYGENASE","PF01494(FAD_binding_3)",5,"LEU A 175;ALA A 311;ASP A 310;GLY A  11;ILE A   9","None;None;FAD A 403 (-2.7A);FAD A 403 (-3.2A);None","0.92A","2rkfA-2rgjA:undetectable","2rkfA-2rgjA:16.93"],["2RKF_A_AB1A501_1","2rsp","Rous sarcoma virus","RSV PROTEASE","PF00077(RVP)",7,"LEU A  35;ASP A  37;GLY A  39;ALA A  40;ASP A  41;ILE A  44;ILE A 108","None","0.38A","2rkfA-2rspA:13.0","2rkfA-2rspA:30.65"],["2RKF_A_AB1A501_1","2wsk","Escherichia coli","GLYCOGEN DEBRANCHING ENZYME","PF00128(Alpha-amylase);PF02922(CBM_48)",5,"LEU A 188;GLY A 255;ALA A 254;ILE A 248;ILE A 185","None","0.78A","2rkfA-2wskA:undetectable","2rkfA-2wskA:9.77"],["2RKF_A_AB1A501_1","2x2g","Trypanosoma brucei","TRIOSEPHOSPHATE ISOMERASE, GLYCOSOMAL","PF00121(TIM)",5,"ALA A 125;ILE A 147;GLY A 128;ALA A 149;ILE A 150","None","0.88A","2rkfA-2x2gA:undetectable","2rkfA-2x2gA:20.35"],["2RKF_A_AB1A501_1","2yjn","Saccharopolyspora erythraea","DTDP-4-KETO-6-DEOXY-HEXOSE 3,4-ISOMERASE","PF00067(p450)",5,"LEU B  39;GLY B 113;ALA B 114;GLY B  30;ILE B  36","None","0.91A","2rkfA-2yjnB:undetectable","2rkfA-2yjnB:15.26"],["2RKF_A_AB1A501_1","3dbg","Streptomyces coelicolor","PUTATIVE CYTOCHROME P450","PF00067(p450)",5,"GLY A 359;ALA A 360;ASP A 361;PRO A  24;ILE A 356","None","0.87A","2rkfA-3dbgA:undetectable","2rkfA-3dbgA:12.17"],["2RKF_A_AB1A501_1","3e4e","Homo sapiens","CYTOCHROME P450 2E1","PF00067(p450)",5,"ALA A 438;ILE A 115;GLY A 300;ILE A 180;ILE A 114","HEM A 500 (-3.8A);HEM A 500 (-4.0A);HEM A 500 (-3.4A);None;HEM A 500 (-4.0A)","0.79A","2rkfA-3e4eA:undetectable","2rkfA-3e4eA:11.56"],["2RKF_A_AB1A501_1","3frv","Homo sapiens","CHARGED MULTIVESICULAR BODY PROTEIN 3","PF03357(Snf7)",5,"LEU A 104;GLY A  90;ILE A 140;ALA A 137;ILE A 139","None","0.84A","2rkfA-3frvA:undetectable","2rkfA-3frvA:20.55"],["2RKF_A_AB1A501_1","3gve","Bacillus subtilis","YFKN PROTEIN","PF00149(Metallophos)",5,"GLY A 121;ALA A 122;ASP A 123;ILE A  89;ILE A 126","None","0.73A","2rkfA-3gveA:undetectable","2rkfA-3gveA:15.71"],["2RKF_A_AB1A501_1","3hkz","Sulfolobus solfataricus","DNA-DIRECTED RNA POLYMERASE SUBUNIT A'","PF00623(RNA_pol_Rpb1_2);PF04983(RNA_pol_Rpb1_3);PF04997(RNA_pol_Rpb1_1);PF04998(RNA_pol_Rpb1_5);PF05000(RNA_pol_Rpb1_4)",5,"GLY A 712;ALA A 711;ILE A 665;GLY A 748;ILE A 661","None","0.91A","2rkfA-3hkzA:undetectable","2rkfA-3hkzA:9.73"],["2RKF_A_AB1A501_1","3k2w","Pseudoalteromonas atlantica","BETAINE-ALDEHYDE DEHYDROGENASE","PF00171(Aldedh)",5,"LEU A  76;GLY A 200;ALA A 199;ILE A  83;GLY A 193","None","0.87A","2rkfA-3k2wA:undetectable","2rkfA-3k2wA:13.29"],["2RKF_A_AB1A501_1","3keh","Homo sapiens","GLUCOCEREBROSIDASE","PF02055(Glyco_hydro_30);PF17189(Glyco_hydro_30C)",5,"ALA A 232;GLY A 307;ILE A 308;ALA A 301;ILE A 260","None","0.82A","2rkfA-3kehA:undetectable","2rkfA-3kehA:12.79"],["2RKF_A_AB1A501_1","3khz","Staphylococcus aureus","PUTATIVE DIPEPTIDASE SACOL1801","PF01546(Peptidase_M20)",6,"LEU A 130;GLY A  73;ALA A  72;GLY A  80;ALA A 126;ILE A 127","None","0.94A","2rkfA-3khzA:undetectable","2rkfA-3khzA:12.80"],["2RKF_A_AB1A501_1","3l49","Rhodobacter sphaeroides","ABC SUGAR (RIBOSE) TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING SUBUNIT","PF13407(Peripla_BP_4)",5,"LEU A 105;ILE A 113;GLY A  35;ILE A  36;ILE A 108","None","0.82A","2rkfA-3l49A:undetectable","2rkfA-3l49A:16.85"],["2RKF_A_AB1A501_1","3mwe","Homo sapiens","ATP-CITRATE SYNTHASE","PF16114(Citrate_bind)",5,"LEU A 301;GLY A 296;ILE A 337;GLY A 416;ILE A 275","None","0.86A","2rkfA-3mweA:undetectable","2rkfA-3mweA:13.00"],["2RKF_A_AB1A501_1","3mws","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;ASP A  29;GLY A  49;ILE A  50","None","1.25A","2rkfA-3mwsA:19.6","2rkfA-3mwsA:70.71"],["2RKF_A_AB1A501_1","3mws","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",8,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;PRO A  81;ILE A  84","None","0.49A","2rkfA-3mwsA:19.6","2rkfA-3mwsA:70.71"],["2RKF_A_AB1A501_1","3mws","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",9,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  29;GLY A  49;ILE A  50;PRO A  81;ILE A  84","None","0.34A","2rkfA-3mwsA:19.6","2rkfA-3mwsA:70.71"],["2RKF_A_AB1A501_1","3one","Lupinus luteus","ADENOSYLHOMOCYSTEINASE","PF00670(AdoHcyase_NAD);PF05221(AdoHcyase)",5,"GLY A 269;ALA A 268;ILE A 331;ILE A 348;ILE A 330","NAD A 501 (-3.6A);NAD A 501 ( 4.8A);None;NAD A 501 (-4.4A);NAD A 501 (-4.8A)","0.88A","2rkfA-3oneA:undetectable","2rkfA-3oneA:13.02"],["2RKF_A_AB1A501_1","3pqv","Kluyveromyces lactis","RCL1 PROTEIN","PF01137(RTC);PF05189(RTC_insert)",5,"LEU A 136;ALA A  99;ILE A 129;ALA A 131;ILE A 132","None","0.83A","2rkfA-3pqvA:undetectable","2rkfA-3pqvA:15.00"],["2RKF_A_AB1A501_1","3slz","Murine leukemia virus","GAG-PRO-POL POLYPROTEIN","PF00077(RVP)",5,"LEU A  30;ASP A  32;GLY A  34;ALA A  35;GLY A  56","None;3TL A 126 (-2.4A);3TL A 126 (-3.1A);3TL A 126 ( 4.0A);3TL A 126 (-3.4A)","0.34A","2rkfA-3slzA:11.3","2rkfA-3slzA:25.95"],["2RKF_A_AB1A501_1","3t3c","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",9,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;ILE A  50;ALA A  82","SO4 A 101 (-4.2A);017 A 201 (-2.6A);017 A 201 (-3.4A);017 A 201 (-3.5A);017 A 201 (-3.5A);017 A 201 (-4.2A);017 A 201 (-4.0A);017 A 201 (-3.3A);SO4 A 101 (-3.5A)","0.53A","2rkfA-3t3cA:18.4","2rkfA-3t3cA:72.73"],["2RKF_A_AB1A501_1","3t3c","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",9,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;PRO A  81;ALA A  82","SO4 A 101 (-4.2A);017 A 201 (-2.6A);017 A 201 (-3.4A);017 A 201 (-3.5A);017 A 201 (-3.5A);017 A 201 (-4.2A);017 A 201 (-4.0A);None;SO4 A 101 (-3.5A)","0.64A","2rkfA-3t3cA:18.4","2rkfA-3t3cA:72.73"],["2RKF_A_AB1A501_1","3ttp","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",6,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;ALA A  22","017 A 201 (-2.6A);017 A 201 (-3.6A);017 A 201 (-3.4A);017 A 201 (-3.3A);017 A 201 (-4.6A);None","1.32A","2rkfA-3ttpA:19.9","2rkfA-3ttpA:81.82"],["2RKF_A_AB1A501_1","3ttp","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",11,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;ILE A  32;GLY A  49;ILE A  50;PRO A  81;ILE A  84","None;017 A 201 (-2.6A);017 A 201 (-3.6A);017 A 201 (-3.4A);017 A 201 (-3.3A);017 A 201 (-4.6A);None;017 A 201 (-3.0A);017 A 201 (-3.3A);017 A 201 (-4.1A);017 A 201 (-4.7A)","0.40A","2rkfA-3ttpA:19.9","2rkfA-3ttpA:81.82"],["2RKF_A_AB1A501_1","3u7s","Human immunodeficiency virus 1","POL POLYPROTEIN","PF00077(RVP)",6,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;ALA A  22","017 A 202 ( 2.5A);017 A 201 ( 3.5A);017 A 201 (-3.4A);017 A 201 (-3.2A);017 A 201 ( 4.0A);None","1.36A","2rkfA-3u7sA:20.2","2rkfA-3u7sA:79.80"],["2RKF_A_AB1A501_1","3u7s","Human immunodeficiency virus 1","POL POLYPROTEIN","PF00077(RVP)",10,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;ILE A  32;GLY A  49;ILE A  50;PRO A  81","None;017 A 202 ( 2.5A);017 A 201 ( 3.5A);017 A 201 (-3.4A);017 A 201 (-3.2A);017 A 201 ( 4.0A);None;017 A 202 (-2.9A);017 A 201 ( 3.5A);017 A 202 (-4.0A)","0.43A","2rkfA-3u7sA:20.2","2rkfA-3u7sA:79.80"],["2RKF_A_AB1A501_1","3uhl","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",7,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  29;ILE A  32;PRO A  81","None","0.48A","2rkfA-3uhlA:16.1","2rkfA-3uhlA:76.77"],["2RKF_A_AB1A501_1","3vas","Schistosoma mansoni","PUTATIVE ADENOSINE KINASE","PF00294(PfkB)",5,"ILE A  73;GLY A  11;ILE A 166;ALA A 305;ILE A 309","None","0.88A","2rkfA-3vasA:undetectable","2rkfA-3vasA:13.76"],["2RKF_A_AB1A501_1","3wbn","Pyrococcus furiosus","PUTATIVE UNCHARACTERIZED PROTEIN","PF01554(MatE)",5,"LEU A 122;ALA A 140;ILE A 111;ALA A 118;ILE A 119","None","0.69A","2rkfA-3wbnA:undetectable","2rkfA-3wbnA:13.38"],["2RKF_A_AB1A501_1","3zq4","Bacillus subtilis","RIBONUCLEASE J 1","PF00753(Lactamase_B);PF07521(RMMBL)",5,"LEU A  86;ILE A  80;GLY A  96;ALA A  38;ILE A  83","None","0.79A","2rkfA-3zq4A:undetectable","2rkfA-3zq4A:11.17"],["2RKF_A_AB1A501_1","4cw5","Bacillus velezensis","DFNA","PF03060(NMO)",5,"GLY A 559;GLY A 732;ILE A 731;PRO A 542;ILE A 539","FMN A1753 (-3.0A);None;None;None;None","0.90A","2rkfA-4cw5A:undetectable","2rkfA-4cw5A:12.47"],["2RKF_A_AB1A501_1","4e3w","Francisella tularensis","ACID PHOSPHATASE","PF00328(His_Phos_2)",5,"ALA A 211;ASP A 207;GLY A 184;ILE A 181;ALA A 159","None","0.91A","2rkfA-4e3wA:undetectable","2rkfA-4e3wA:14.67"],["2RKF_A_AB1A501_1","4gmk","Lactobacillus salivarius","RIBOSE-5-PHOSPHATE ISOMERASE A","PF06026(Rib_5-P_isom_A)",5,"GLY A 100;ALA A 101;GLY A 204;ILE A  96;ILE A 176","PO4 A 301 (-3.6A);None;None;None;None","0.91A","2rkfA-4gmkA:undetectable","2rkfA-4gmkA:18.93"],["2RKF_A_AB1A501_1","4h6q","Deinococcus radiodurans","PROLINE DEHYDROGENASE","PF01619(Pro_dh)",5,"GLY A  90;ALA A  89;ILE A  83;ALA A  43;ILE A  44","None","0.76A","2rkfA-4h6qA:undetectable","2rkfA-4h6qA:16.99"],["2RKF_A_AB1A501_1","4hdj","Pseudomonas aeruginosa","OUTER MEMBRANE PROTEIN ASSEMBLY FACTOR BAMB","PF13360(PQQ_2)",5,"ASP A 207;GLY A 160;ILE A 159;PRO A 187;ALA A 196","None","0.71A","2rkfA-4hdjA:undetectable","2rkfA-4hdjA:13.43"],["2RKF_A_AB1A501_1","4ida","Fragaria vesca","RIPENING-INDUCED PROTEIN","PF08240(ADH_N);PF13602(ADH_zinc_N_2)",5,"GLY A 208;ALA A 209;ASP A 210;ILE A 179;ALA A 196","None;None;None;None;SO4 A 402 (-3.3A)","0.89A","2rkfA-4idaA:undetectable","2rkfA-4idaA:18.09"],["2RKF_A_AB1A501_1","4ida","Fragaria vesca","RIPENING-INDUCED PROTEIN","PF08240(ADH_N);PF13602(ADH_zinc_N_2)",5,"LEU A 203;GLY A 208;ALA A 209;ASP A 210;ILE A 179","None","0.87A","2rkfA-4idaA:undetectable","2rkfA-4idaA:18.09"],["2RKF_A_AB1A501_1","4j8l","Escherichia coli","UNCHARACTERIZED PROTEIN YHFS","PF00155(Aminotran_1_2)",5,"LEU A  59;ALA A  65;ASP A 209;GLY A 182;ALA A 205","None","0.90A","2rkfA-4j8lA:undetectable","2rkfA-4j8lA:15.00"],["2RKF_A_AB1A501_1","4njv","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",5,"ALA A  28;ASP A  29;ASP A  30;GLY A  48;ILE A  84","RIT A 500 (-3.6A);RIT A 500 (-3.2A);RIT A 500 (-4.8A);RIT A 500 (-4.8A);RIT A 500 (-4.3A)","0.72A","2rkfA-4njvA:20.6","2rkfA-4njvA:80.81"],["2RKF_A_AB1A501_1","4njv","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",8,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;PRO A  81;ILE A  84","None;RIT A 500 (-2.4A);RIT A 500 (-3.9A);RIT A 500 (-3.6A);RIT A 500 (-3.2A);RIT A 500 (-4.8A);RIT A 500 (-3.9A);RIT A 500 (-4.3A)","0.44A","2rkfA-4njvA:20.6","2rkfA-4njvA:80.81"],["2RKF_A_AB1A501_1","4njv","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",9,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  29;GLY A  49;ILE A  50;PRO A  81;ILE A  84","None;RIT A 500 (-2.4A);RIT A 500 (-3.9A);RIT A 500 (-3.6A);RIT A 500 (-3.2A);RIT A 500 (-3.4A);RIT A 500 (-4.3A);RIT A 500 (-3.9A);RIT A 500 (-4.3A)","0.38A","2rkfA-4njvA:20.6","2rkfA-4njvA:80.81"],["2RKF_A_AB1A501_1","4o89","Pyrococcus horikoshii","RNA 3'-TERMINAL PHOSPHATE CYCLASE","PF01137(RTC);PF05189(RTC_insert)",5,"GLY A 296;ILE A 145;ILE A 289;ALA A 139;ILE A 143","None","0.78A","2rkfA-4o89A:undetectable","2rkfA-4o89A:17.69"],["2RKF_A_AB1A501_1","4rgh","Homo sapiens","PROTEIN DDI1 HOMOLOG 2","PF09668(Asp_protease)",5,"ASP A 220;GLY A 222;ALA A 223;ILE A 227;GLY A 252","None","0.85A","2rkfA-4rghA:10.6","2rkfA-4rghA:20.12"],["2RKF_A_AB1A501_1","4rgh","Homo sapiens","PROTEIN DDI1 HOMOLOG 2","PF09668(Asp_protease)",5,"ASP A 220;GLY A 222;ALA A 223;ILE A 227;PRO A 285","None","0.61A","2rkfA-4rghA:10.6","2rkfA-4rghA:20.12"],["2RKF_A_AB1A501_1","4tnb","Homo sapiens","G PROTEIN-COUPLED RECEPTOR KINASE 5","PF00069(Pkinase);PF00615(RGS)",5,"LEU A  45;ASP A  52;GLY A  63;ILE A  62;ILE A  49","None","0.85A","2rkfA-4tnbA:undetectable","2rkfA-4tnbA:11.81"],["2RKF_A_AB1A501_1","4ttp","Legionella pneumophila","DEPHOSPHO-COA KINASE","PF01121(CoaE)",5,"LEU A 168;ALA A 175;ASP A 176;ASP A 177;ILE A 118","None","0.86A","2rkfA-4ttpA:undetectable","2rkfA-4ttpA:18.63"],["2RKF_A_AB1A501_1","4ydf","Primate T-lymphotropic virus 1","HTLV-1 PROTEASE","PF00077(RVP)",7,"LEU A  30;ASP A  32;GLY A  34;ALA A  35;ASP A  36;GLY A  58;ILE A 100","None;4B1 A 201 (-2.9A);4B1 A 201 ( 4.6A);4B1 A 201 (-3.6A);4B1 A 201 (-4.4A);4B1 A 201 (-3.4A);4B1 A 201 (-4.8A)","0.39A","2rkfA-4ydfA:13.2","2rkfA-4ydfA:34.19"],["2RKF_A_AB1A501_1","5b0h","Homo sapiens","LEUKOCYTE CELL-DERIVED CHEMOTAXIN-2","PF01551(Peptidase_M23)",5,"GLY A  99;ALA A  50;ILE A  56;GLY A 103;ILE A  96","None","0.85A","2rkfA-5b0hA:undetectable","2rkfA-5b0hA:18.52"],["2RKF_A_AB1A501_1","5b18","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",7,"GLY A  27;ALA A  28;ASP A  29;ASP A  30;ILE A  32;PRO A  81;ILE A  84","None","0.49A","2rkfA-5b18A:17.9","2rkfA-5b18A:74.75"],["2RKF_A_AB1A501_1","5b18","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",5,"GLY A  27;ALA A  28;ASP A  29;GLY A  49;ILE A  84","None","0.69A","2rkfA-5b18A:17.9","2rkfA-5b18A:74.75"],["2RKF_A_AB1A501_1","5c04","Mycobacterium tuberculosis","PUTATIVE PEROXIREDOXIN MT2298","PF00578(AhpC-TSA)",5,"ALA A 130;GLY A 105;PRO A   9;ALA A   8;ILE A 127","None","0.87A","2rkfA-5c04A:undetectable","2rkfA-5c04A:18.75"],["2RKF_A_AB1A501_1","5cio","Serratia sp. FS14","PYRROLOQUINOLINE QUINONE BIOSYNTHESIS PROTEIN PQQF","PF00675(Peptidase_M16);PF05193(Peptidase_M16_C)",5,"LEU A 554;ALA A 681;GLY A 662;ALA A 550;ILE A 551","None","0.89A","2rkfA-5cioA:undetectable","2rkfA-5cioA:9.16"],["2RKF_A_AB1A501_1","5cw2","Mycolicibacterium thermoresistibile","PUTATIVE EPOXIDE HYDROLASE EPHA","no annotation",5,"LEU C 315;GLY C  53;ALA C  52;ILE C  46;ILE C 312","None","0.80A","2rkfA-5cw2C:undetectable","2rkfA-5cw2C:12.62"],["2RKF_A_AB1A501_1","5e31","Enterococcus faecium","PENICILLIN BINDING PROTEIN 2 PRIME","PF00905(Transpeptidase);PF03717(PBP_dimer);PF05223(MecA_N)",5,"LEU A 184;GLY A 276;ILE A 343;ILE A 514;ILE A 176","None","0.87A","2rkfA-5e31A:undetectable","2rkfA-5e31A:9.05"],["2RKF_A_AB1A501_1","5gan","Saccharomyces cerevisiae","PRE-MRNA-PROCESSING FACTOR 31","PF01798(Nop);PF09785(Prp31_C)",5,"GLY F 247;ILE F 222;GLY F 215;ILE F 214;ILE F 225","None","0.70A","2rkfA-5ganF:undetectable","2rkfA-5ganF:11.22"],["2RKF_A_AB1A501_1","5il5","Bacillus velezensis","MLND","PF14765(PS-DH)",5,"GLY A1310;ALA A1309;ILE A1278;ILE A1303;ILE A1341","None","0.69A","2rkfA-5il5A:undetectable","2rkfA-5il5A:16.61"],["2RKF_A_AB1A501_1","5irp","Bacillus subtilis","ALANINE RACEMASE 2","PF00842(Ala_racemase_C);PF01168(Ala_racemase_N)",5,"GLY A  77;ALA A  76;GLY A  70;ILE A  82;ILE A  48","None","0.87A","2rkfA-5irpA:undetectable","2rkfA-5irpA:13.39"],["2RKF_A_AB1A501_1","5ldn","Human mastadenovirus C","HEXON PROTEIN,HEXON CAPSID","PF01065(Adeno_hexon);PF03678(Adeno_hexon_C)",5,"GLY A 220;ALA A 171;ILE A 215;GLY A 206;ILE A 205","None","0.78A","2rkfA-5ldnA:undetectable","2rkfA-5ldnA:8.03"],["2RKF_A_AB1A501_1","5nd1","Rosellinia necatrix quadrivirus 1","CAPSID PROTEIN","no annotation",5,"GLY A 778;ALA A 779;ILE A 787;ALA A 809;ILE A 805","None","0.89A","2rkfA-5nd1A:undetectable","2rkfA-5nd1A:19.79"],["2RKF_A_AB1A501_1","5t2z","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",6,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;ALA A  22","None","1.32A","2rkfA-5t2zA:20.6","2rkfA-5t2zA:75.76"],["2RKF_A_AB1A501_1","5t2z","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;ASP A  29;GLY A  49;ILE A  50","None","1.23A","2rkfA-5t2zA:20.6","2rkfA-5t2zA:75.76"],["2RKF_A_AB1A501_1","5t2z","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",10,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;ILE A  50;PRO A  81;ILE A  84","None","0.39A","2rkfA-5t2zA:20.6","2rkfA-5t2zA:75.76"],["2RKF_A_AB1A501_1","5tus","Homo sapiens","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT","PF00317(Ribonuc_red_lgN);PF02867(Ribonuc_red_lgC);PF03477(ATP-cone)",5,"GLY A 538;ALA A 539;ILE A 501;ALA A 447;ILE A 503","None","0.83A","2rkfA-5tusA:undetectable","2rkfA-5tusA:9.32"],["2RKF_A_AB1A501_1","5w4b","Homo sapiens","ADENOSYLHOMOCYSTEINASE","PF00670(AdoHcyase_NAD);PF05221(AdoHcyase)",5,"GLY A 220;ALA A 219;ILE A 282;ILE A 299;ILE A 281","NAD A 501 ( 3.7A);None;None;NAD A 501 (-4.3A);NAD A 501 (-4.8A)","0.85A","2rkfA-5w4bA:undetectable","2rkfA-5w4bA:14.76"],["2RKF_A_AB1A501_1","5xhw","Yersinia pseudotuberculosis","PUTATIVE 6-DEOXY-D-MANNOHEPTOSE PATHWAY PROTEIN","no annotation",5,"LEU A 113;GLY A 168;ASP A 210;ILE A 164;ALA A 206","None","0.87A","2rkfA-5xhwA:undetectable","2rkfA-5xhwA:23.23"],["2RKF_A_AB1A501_1","5xj1","Streptococcus pneumoniae","UNCHARACTERIZED RNA METHYLTRANSFERASE SP_1029","no annotation",6,"GLY A 399;ALA A 400;ASP A 401;ILE A 373;ALA A 311;ILE A 378","None","0.97A","2rkfA-5xj1A:undetectable","2rkfA-5xj1A:13.76"],["2RKF_A_AB1A501_1","5xoz","Cicer arietinum","TRYPSIN PROTEIN INHIBITOR 2","no annotation",5,"GLY A 133;ILE A 117;GLY A 149;ALA A 115;ILE A 106","None","0.79A","2rkfA-5xozA:undetectable","2rkfA-5xozA:21.57"],["2RKF_A_AB1A501_1","5zgb","Cyanidioschyzon merolae","PSAL","no annotation",5,"LEU L  89;GLY L  51;ALA L 125;ILE L  83;ILE L  86","BCR L 205 (-3.7A);None;None;None;None","0.81A","2rkfA-5zgbL:undetectable","2rkfA-5zgbL:23.47"],["2RKF_A_AB1A501_1","6ehi","Helicobacter pylori","NUCLEASE NUCT","no annotation",5,"ALA A  24;ILE A 110;ILE A  18;ALA A 104;ILE A 106","None","0.92A","2rkfA-6ehiA:undetectable","2rkfA-6ehiA:18.37"],["2RKF_A_AB1A501_1","6fiv","Feline immunodeficiency virus","RETROPEPSIN","PF00077(RVP)",7,"LEU A  28;ASP A  30;GLY A  32;ALA A  33;ASP A  34;ILE A  37;GLY A  58","None;3TL A 201 (-3.5A);3TL A 201 (-3.4A);3TL A 201 (-4.0A);3TL A 201 (-3.9A);3TL A 201 ( 4.8A);3TL A 201 (-3.4A)","0.39A","2rkfA-6fivA:15.6","2rkfA-6fivA:28.32"],["2RKF_A_AB1A501_1","6upj","Human immunodeficiency virus 2","HIV-2 PROTEASE","PF00077(RVP)",10,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;ILE A  32;GLY A  49;PRO A  81;ILE A  84","None;NIU A 100 (-2.8A);NIU A 100 (-4.5A);NIU A 100 (-3.6A);None;None;None;NIU A 100 ( 3.8A);None;None","0.61A","2rkfA-6upjA:18.2","2rkfA-6upjA:49.49"],["2RKF_A_AB1A501_1","6upj","Human immunodeficiency virus 2","HIV-2 PROTEASE","PF00077(RVP)",10,"LEU A  23;ASP A  25;GLY A  27;ASP A  29;ASP A  30;ILE A  32;GLY A  49;ILE A  50;PRO A  81;ILE A  84","None;NIU A 100 (-2.8A);NIU A 100 (-4.5A);None;None;None;NIU A 100 ( 3.8A);NIU A 100 (-3.9A);None;None","0.66A","2rkfA-6upjA:18.2","2rkfA-6upjA:49.49"]]