SIMILAR PATTERNS OF AMINO ACIDS FOR 2RK8_A_PPFA3969

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aei ANNEXIN XII

(Hydra vulgaris) 		PF00191
(Annexin) 		4 SER A 263
ASP A 104
ARG A 252
ALA A 256
 None
 1.34A 2rk8A-1aeiA:
undetectable		 2rk8A-1aeiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amo NADPH-CYTOCHROME
P450 REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 ARG A 519
HIS A 319
SER A 516
ASP A 675
 None
FAD  A 750 (-3.8A)
None
None
 1.39A 2rk8A-1amoA:
undetectable		 2rk8A-1amoA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bun BETA2-BUNGAROTOXIN

(Bungarus
multicinctus) 		PF00068
(Phospholip_A2_1) 		4 LYS A   1
HIS A  48
ASP A  94
ALA A  55
 None
 1.38A 2rk8A-1bunA:
2.1		 2rk8A-1bunA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1col COLICIN A

(Escherichia
coli) 		PF01024
(Colicin) 		4 ARG A  54
SER A  62
ASP A 193
ALA A 185
 None
 1.26A 2rk8A-1colA:
2.0		 2rk8A-1colA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyx CYOA

(Escherichia
coli) 		PF00116
(COX2)
PF06481
(COX_ARM) 		4 HIS A 172
SER A 167
ASP A 135
ALA A 187
 CUA  A 316 (-2.9A)
None
None
None
 1.14A 2rk8A-1cyxA:
undetectable		 2rk8A-1cyxA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpy PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		4 LYS A   1
HIS A  48
ASP A  94
ALA A  55
 None
 1.39A 2rk8A-1dpyA:
2.1		 2rk8A-1dpyA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fyh INTERFERON GAMMA
INTERFERON GAMMA
RECEPTOR 1

(Homo sapiens) 		PF00714
(IFN-gamma)
PF01108
(Tissue_fac)
PF07140
(IFNGR1) 		4 ARG B 106
HIS A 311
SER B  80
ALA B 103
 None
 0.86A 2rk8A-1fyhB:
undetectable		 2rk8A-1fyhB:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fyh INTERFERON GAMMA
INTERFERON GAMMA
RECEPTOR 1

(Homo sapiens) 		PF00714
(IFN-gamma)
PF01108
(Tissue_fac)
PF07140
(IFNGR1) 		4 LYS A  12
HIS A 311
SER B  80
ALA B 103
 None
 1.32A 2rk8A-1fyhA:
2.3		 2rk8A-1fyhA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hds HEMOGLOBIN S (DEOXY)
(ALPHA CHAIN)
HEMOGLOBIN S (DEOXY)
(BETA CHAIN)

(Odocoileus
virginianus) 		PF00042
(Globin) 		4 ARG A  31
HIS A 112
SER A 111
ALA B 114
 None
 1.35A 2rk8A-1hdsA:
3.2		 2rk8A-1hdsA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 LYS A 539
SER A 592
ASP A 587
ALA A 616
 None
 1.42A 2rk8A-1hn0A:
2.2		 2rk8A-1hn0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03372
(Exo_endo_phos) 		4 ARG A 744
HIS A 839
ASP A 816
ALA A 702
 2IP  A 302 (-2.8A)
None
None
2IP  A 302 ( 3.8A)
 0.94A 2rk8A-1i9zA:
3.1		 2rk8A-1i9zA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia7 CELLULASE CEL9M

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9) 		4 LYS A  62
HIS A  39
ASP A  42
ALA A  26
 None
ZN  A1333 (-3.1A)
None
None
 1.34A 2rk8A-1ia7A:
undetectable		 2rk8A-1ia7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Trypanosoma
cruzi) 		PF01293
(PEPCK_ATP) 		6 ARG A  43
LYS A 185
LYS A 186
HIS A 205
ASP A 242
ARG A 307
 None
 0.85A 2rk8A-1ii2A:
31.3		 2rk8A-1ii2A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		6 ARG A  52
LYS A 196
LYS A 197
HIS A 216
ASP A 253
ARG A 319
 None
 0.97A 2rk8A-1j3bA:
30.0		 2rk8A-1j3bA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 ARG A 436
HIS A 347
ASP A 400
ALA A 446
 None
 1.41A 2rk8A-1lf9A:
3.0		 2rk8A-1lf9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m8t PHOSPHOLIPASE A2

(Ophiophagus
hannah) 		PF00068
(Phospholip_A2_1) 		4 LYS A   1
HIS A  48
ASP A  99
ALA A  55
 None
 1.29A 2rk8A-1m8tA:
2.0		 2rk8A-1m8tA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF01380
(SIS) 		4 HIS A 294
ASP A 323
ARG A 333
ALA A 336
 None
 1.35A 2rk8A-1morA:
undetectable		 2rk8A-1morA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1po8 PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		4 LYS A   1
HIS A  48
ASP A  94
ALA A  55
 None
SHV  A 122 (-4.1A)
None
None
 1.24A 2rk8A-1po8A:
2.0		 2rk8A-1po8A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjw ALCOHOL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 HIS A  61
ASP A  41
ARG A 331
ALA A 149
 ZN  A 402 (-3.2A)
None
None
None
 1.32A 2rk8A-1rjwA:
undetectable		 2rk8A-1rjwA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		4 ARG A 257
LYS A 263
LYS A 255
ASP A 310
 None
 1.30A 2rk8A-1vcjA:
undetectable		 2rk8A-1vcjA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Actinobacillus
succinogenes) 		PF01293
(PEPCK_ATP) 		6 ARG A  65
LYS A 212
LYS A 213
HIS A 232
ASP A 269
ARG A 333
 None
 0.96A 2rk8A-1yggA:
27.7		 2rk8A-1yggA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		4 LYS A 404
LYS A 441
ASP A 370
ALA A  79
 SO4  A1000 (-2.9A)
SO4  A1000 (-2.8A)
SO4  A1000 (-3.0A)
None
 1.40A 2rk8A-1yp4A:
undetectable		 2rk8A-1yp4A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		4 LYS A 441
SER A  80
ASP A 370
ALA A  45
 SO4  A1000 (-2.8A)
SO4  A1000 (-2.9A)
SO4  A1000 (-3.0A)
None
 0.88A 2rk8A-1yp4A:
undetectable		 2rk8A-1yp4A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		7 ARG A  60
LYS A 205
LYS A 206
HIS A 225
SER A 244
ASP A 263
ARG A 327
 OXD  A 543 (-4.1A)
OXD  A 543 ( 4.2A)
MN  A 999 ( 2.4A)
MN  A 999 (-3.4A)
OXD  A 543 ( 2.3A)
MN  A 999 (-2.5A)
ATP  A 541 ( 2.8A)
 0.70A 2rk8A-1ytmA:
30.7		 2rk8A-1ytmA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 HIS A1462
SER A1382
ASP A1413
ALA A1369
 None
 1.30A 2rk8A-2b39A:
undetectable		 2rk8A-2b39A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE

(Thermus
thermophilus) 		PF01966
(HD)
PF13286
(HD_assoc) 		4 HIS A 108
ASP A 109
ARG A  74
ALA A 199
 MG  A 506 (-4.6A)
MG  A 506 (-2.9A)
None
None
 1.18A 2rk8A-2dqbA:
undetectable		 2rk8A-2dqbA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN

(Daboia
siamensis) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 ARG A 413
LYS A 357
LYS A 352
ARG A 369
 None
 1.38A 2rk8A-2e3xA:
3.0		 2rk8A-2e3xA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Aquifex
aeolicus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ARG A  12
HIS A  51
SER A  16
ASP A 321
 None
 1.30A 2rk8A-2ep7A:
undetectable		 2rk8A-2ep7A:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Gallus gallus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		6 ARG A 105
LYS A 262
LYS A 263
HIS A 283
ASP A 330
ARG A 424
 1PE  A1262 (-3.7A)
1PE  A1262 (-4.3A)
MN  A1701 ( 1.9A)
MN  A1701 (-3.2A)
MN  A1701 (-2.3A)
1PE  A1262 (-3.0A)
 0.67A 2rk8A-2fafA:
53.8		 2rk8A-2fafA:
63.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fl1 RED FLUORESCENT
PROTEIN ZOANRFP

(Zoanthus sp.) 		PF01353
(GFP) 		4 LYS A  69
HIS A 122
ARG A  95
ALA A  63
 XYG  A  66 ( 3.6A)
XYG  A  66 ( 4.4A)
XYG  A  66 ( 3.0A)
XYG  A  66 ( 4.0A)
 1.32A 2rk8A-2fl1A:
undetectable		 2rk8A-2fl1A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7b APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 LYS A 242
ASP A 110
ARG A 103
ALA A 102
 None
 1.40A 2rk8A-2l7bA:
undetectable		 2rk8A-2l7bA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osn PHOSPHOLIPASE A2
ISOFORM 3

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		4 LYS A   3
HIS A  48
ASP A  94
ALA A  55
 None
 1.29A 2rk8A-2osnA:
2.0		 2rk8A-2osnA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506

(Zoanthus sp.) 		PF01353
(GFP) 		4 LYS A  69
HIS A 122
ARG A  95
ALA A  63
 DYG  A  66 ( 3.5A)
XYG  A  66 ( 3.8A)
XYG  A  66 ( 2.7A)
DYG  A  66 ( 3.8A)
 1.33A 2rk8A-2pxsA:
undetectable		 2rk8A-2pxsA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE

(Agrobacterium
fabrum) 		PF06559
(DCD) 		4 ARG A  47
SER A  30
ARG A 160
ALA A  32
 None
 1.32A 2rk8A-2r9qA:
undetectable		 2rk8A-2r9qA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbp L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
vinaceus) 		PF02668
(TauD) 		4 HIS A 225
SER A 224
ASP A 171
ARG A 334
 None
ZZU  A1359 (-3.2A)
ZZU  A1359 ( 4.9A)
ZZU  A1359 ( 2.9A)
 1.31A 2rk8A-2wbpA:
undetectable		 2rk8A-2wbpA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Homo sapiens) 		PF05645
(RNA_pol_Rpc82)
PF08221
(HTH_9) 		4 SER A 279
ASP A 240
ARG A 247
ALA A 282
 None
 1.18A 2rk8A-2xubA:
undetectable		 2rk8A-2xubA:
23.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Corynebacterium
glutamicum) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 LYS A 229
LYS A 230
HIS A 250
ASP A 297
ARG A 389
 None
 0.53A 2rk8A-2zciA:
49.5		 2rk8A-2zciA:
48.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 HIS A 214
SER A  58
ASP A  17
ALA A  62
 None
 1.15A 2rk8A-3gdnA:
undetectable		 2rk8A-3gdnA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsi PHOSPHATIDYLSERINE
SYNTHASE

(Haemophilus
influenzae) 		PF13091
(PLDc_2) 		4 LYS A 363
SER A 155
ASP A 170
ALA A  54
 None
 1.38A 2rk8A-3hsiA:
undetectable		 2rk8A-3hsiA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ih6 PUTATIVE ZINC
PROTEASE

(Bordetella
pertussis) 		PF05193
(Peptidase_M16_C) 		4 ARG A 377
LYS A 381
SER A 310
ASP A 307
 None
None
None
EDO  A 501 (-3.3A)
 1.25A 2rk8A-3ih6A:
undetectable		 2rk8A-3ih6A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isa PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Bordetella
parapertussis) 		PF00378
(ECH_1) 		4 ARG A 214
HIS A 217
ASP A 150
ALA A  96
 None
 1.02A 2rk8A-3isaA:
undetectable		 2rk8A-3isaA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ive NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 HIS A 116
SER A  87
ASP A 115
ALA A  35
 None
None
CTN  A 603 ( 4.1A)
None
 1.38A 2rk8A-3iveA:
undetectable		 2rk8A-3iveA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kar KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		4 ARG A 394
HIS A 706
SER A 703
ALA A 396
 None
 1.39A 2rk8A-3karA:
undetectable		 2rk8A-3karA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		4 ARG A 254
HIS A 199
ASP A 118
ARG A 122
 PO4  A 500 (-3.1A)
ZN  A 505 (-3.3A)
ZN  A 505 (-2.7A)
PO4  A 500 (-2.9A)
 1.36A 2rk8A-3ll8A:
undetectable		 2rk8A-3ll8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lto MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Legionella
pneumophila) 		no annotation 4 LYS A  23
SER A 200
ASP A 291
ALA A 203
 SO4  A 400 (-4.7A)
None
SO4  A 400 (-4.2A)
None
 1.42A 2rk8A-3ltoA:
undetectable		 2rk8A-3ltoA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 ARG A 451
HIS A 549
ASP A 524
ALA A 403
 None
 0.87A 2rk8A-3n9vA:
undetectable		 2rk8A-3n9vA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfb BETA-PEPTIDYL
AMINOPEPTIDASE

(Sphingosinicella
xenopeptidilytica) 		PF03576
(Peptidase_S58) 		4 ARG A 189
SER A 187
ASP A  23
ALA A 331
 None
 1.02A 2rk8A-3nfbA:
undetectable		 2rk8A-3nfbA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		4 HIS A  98
SER A 102
ASP A  64
ALA A 105
 None
 1.33A 2rk8A-3nzqA:
2.4		 2rk8A-3nzqA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s0m OXALATE
DECARBOXYLASE OXDC

(Bacillus
subtilis) 		PF00190
(Cupin_1) 		4 LYS A 375
HIS A 273
ASP A 342
ALA A 260
 None
MN  A 501 (-3.5A)
None
None
 1.37A 2rk8A-3s0mA:
undetectable		 2rk8A-3s0mA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		4 LYS A 422
ASP A 444
ARG A 232
ALA A 245
 NDP  A 801 ( 4.1A)
NDP  A 801 (-3.6A)
None
None
 1.34A 2rk8A-3slkA:
undetectable		 2rk8A-3slkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2n SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09272
(Hepsin-SRCR) 		4 HIS A 262
SER A 408
ASP A 196
ARG A  97
 None
 1.41A 2rk8A-3t2nA:
undetectable		 2rk8A-3t2nA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C) 		4 ARG A 146
LYS A   9
SER A 364
ASP A  12
 None
 1.41A 2rk8A-3t8lA:
undetectable		 2rk8A-3t8lA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vre HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID

(Mammuthus
primigenius) 		PF00042
(Globin) 		4 ARG A  31
HIS A 112
SER A 111
ALA B 115
 None
 1.22A 2rk8A-3vreA:
3.6		 2rk8A-3vreA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w64 MAGNETOSOME PROTEIN
MAMM

(Magnetospirillum
gryphiswaldense) 		PF16916
(ZT_dimer) 		4 HIS A 285
SER A 283
ASP A 249
ARG A 240
 None
 1.41A 2rk8A-3w64A:
undetectable		 2rk8A-3w64A:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aah METHANOL
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF13360
(PQQ_2) 		4 LYS A 121
HIS A  68
ASP A 108
ALA A  17
 None
 1.05A 2rk8A-4aahA:
undetectable		 2rk8A-4aahA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF04153
(NOT2_3_5) 		4 HIS B  50
ASP C 457
ARG C 495
ALA C 466
 None
 1.34A 2rk8A-4by6B:
undetectable		 2rk8A-4by6B:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		4 LYS A 329
SER A 203
ASP A 269
ARG A 516
 EDO  A1534 (-3.4A)
None
EDO  A1534 (-4.3A)
EDO  A1534 ( 3.7A)
 1.31A 2rk8A-4c1sA:
undetectable		 2rk8A-4c1sA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 ARG A 426
HIS A 524
ASP A 499
ALA A 378
 None
PO4  A1560 (-3.8A)
None
GOL  A1562 ( 4.4A)
 0.93A 2rk8A-4cmnA:
undetectable		 2rk8A-4cmnA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csu GTPASE OBGE/CGTA

(Escherichia
coli) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		4 LYS 9  89
HIS 9 111
ASP 9  50
ALA 9 160
 None
 1.11A 2rk8A-4csu9:
undetectable		 2rk8A-4csu9:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga7 LEUKOCYTE ELASTASE
INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		4 HIS A 364
SER A 367
ASP A  76
ARG A  69
 None
 1.21A 2rk8A-4ga7A:
undetectable		 2rk8A-4ga7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 ARG A  40
SER A 396
ASP A  47
ALA A 413
 None
 1.27A 2rk8A-4h1sA:
undetectable		 2rk8A-4h1sA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8)
no annotation 		4 HIS B 183
SER A  96
ASP B 126
ALA B 284
 None
 1.21A 2rk8A-4i0wB:
undetectable		 2rk8A-4i0wB:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF02277
(DBI_PRT) 		4 HIS A 289
SER A 291
ASP A 263
ALA A 296
 None
 1.40A 2rk8A-4kqkA:
undetectable		 2rk8A-4kqkA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq8 SCA-FAMILY PROTEIN

(Rickettsia
rickettsii) 		PF12574
(120_Rick_ant) 		4 ARG A 328
LYS A 332
ASP A 347
ALA A 351
 None
 0.84A 2rk8A-4lq8A:
undetectable		 2rk8A-4lq8A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ltm NADH-DEPENDENT FMN
REDUCTASE

(EDTA-degrading
bacterium BNC1) 		PF03358
(FMN_red) 		4 HIS A 170
SER A 174
ARG A 134
ALA A 104
 None
 1.32A 2rk8A-4ltmA:
undetectable		 2rk8A-4ltmA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 SER A 378
ASP A 376
ARG A 757
ALA A 632
 None
CXS  A 908 (-3.9A)
None
None
 1.29A 2rk8A-4nhoA:
undetectable		 2rk8A-4nhoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oaq R-SPECIFIC CARBONYL
REDUCTASE

(Candida
parapsilosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LYS A  31
ASP A  37
ARG A 129
ALA A 120
 None
 1.27A 2rk8A-4oaqA:
undetectable		 2rk8A-4oaqA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		7 ARG A  87
LYS A 243
LYS A 244
HIS A 264
SER A 286
ASP A 311
ARG A 405
 SPV  A 704 (-3.8A)
SPV  A 704 (-4.5A)
MN  A 701 ( 2.4A)
MN  A 701 (-3.4A)
SPV  A 704 ( 2.8A)
MN  A 701 (-2.5A)
GTP  A 703 ( 2.8A)
 0.33A 2rk8A-4ox2A:
61.0		 2rk8A-4ox2A:
99.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph0 BLV CAPSID

(Bovine leukemia
virus) 		PF00607
(Gag_p24) 		4 ARG A  12
LYS A   1
ASP A  53
ALA A  15
 None
 1.18A 2rk8A-4ph0A:
undetectable		 2rk8A-4ph0A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN B CHAIN
GLOBIN C CHAIN

(Glossoscolex
paulistus) 		PF00042
(Globin) 		4 ARG B  16
LYS B  12
SER C  27
ASP B  79
 None
 1.34A 2rk8A-4u8uB:
undetectable		 2rk8A-4u8uB:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		4 HIS A 201
SER A 188
ASP A  15
ARG A  22
 None
 1.32A 2rk8A-4uw2A:
undetectable		 2rk8A-4uw2A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE

(Pectobacterium
atrosepticum) 		PF02275
(CBAH) 		4 ARG A 278
LYS A   1
ASP A  22
ALA A 293
 None
 1.17A 2rk8A-4wl2A:
undetectable		 2rk8A-4wl2A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu4 HEMOGLOBIN

(Helogale
parvula) 		PF00042
(Globin) 		4 ARG A  31
HIS A 112
SER A 111
ALA B 115
 None
 1.24A 2rk8A-4yu4A:
3.7		 2rk8A-4yu4A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT

(Xenopus laevis) 		PF01094
(ANF_receptor) 		4 HIS A 146
SER A 145
ASP A 366
ALA A 175
 None
 1.27A 2rk8A-5b3jA:
undetectable		 2rk8A-5b3jA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9l PLL LECTIN

(Photorhabdus
luminescens) 		PF03984
(DUF346) 		4 ARG A 236
ASP A 220
ARG A 188
ALA A  21
 None
 1.42A 2rk8A-5c9lA:
undetectable		 2rk8A-5c9lA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 ARG A 183
SER A 173
ASP A 444
ALA A 170
 None
 1.32A 2rk8A-5cniA:
undetectable		 2rk8A-5cniA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 ARG A 739
LYS A 732
ASP A 666
ALA A 696
 None
 1.35A 2rk8A-5d0fA:
undetectable		 2rk8A-5d0fA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF13476
(AAA_23) 		4 ARG A  13
SER A  59
ASP A 160
ALA A  64
 AGS  A1402 (-4.2A)
None
None
AGS  A1402 (-4.9A)
 1.36A 2rk8A-5dacA:
3.0		 2rk8A-5dacA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG

(Homo sapiens) 		PF02724
(CDC45) 		4 LYS A 232
HIS A 101
ASP A 543
ALA A  29
 None
 1.36A 2rk8A-5dgoA:
2.4		 2rk8A-5dgoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn8 GTPASE DER

(Coxiella
burnetii) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		4 ARG A 236
SER A 189
ASP A 229
ALA A 237
 GDP  A 501 (-2.9A)
GDP  A 501 (-4.5A)
None
None
 1.19A 2rk8A-5dn8A:
2.3		 2rk8A-5dn8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE

([Eubacterium]
rectale) 		PF00078
(RVT_1) 		4 ARG A  66
ASP A  33
ARG A  88
ALA A  29
 None
 1.26A 2rk8A-5hhlA:
undetectable		 2rk8A-5hhlA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxz BARBITURASE

(Rhodococcus
erythropolis) 		PF09663
(Amido_AtzD_TrzD) 		4 HIS A 324
SER A 349
ARG A 220
ALA A 351
 None
MHA  A 403 ( 4.6A)
None
None
 1.28A 2rk8A-5hxzA:
undetectable		 2rk8A-5hxzA:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Mycobacterium
tuberculosis) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		6 ARG A  81
LYS A 228
LYS A 229
HIS A 249
ASP A 296
ARG A 388
 None
None
MN  A 705 (-3.1A)
MN  A 705 (-4.5A)
MN  A 705 (-3.5A)
None
 0.71A 2rk8A-5i67A:
41.6		 2rk8A-5i67A:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Mycobacterium
tuberculosis) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		6 LYS A 228
LYS A 229
HIS A 249
SER A 271
ASP A 296
ARG A 388
 None
MN  A 705 (-3.1A)
MN  A 705 (-4.5A)
MN  A 705 (-4.7A)
MN  A 705 (-3.5A)
None
 1.02A 2rk8A-5i67A:
41.6		 2rk8A-5i67A:
51.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00171
(Aldedh) 		4 ARG A 459
LYS A 463
LYS A 460
ASP A 434
 None
 0.94A 2rk8A-5jfmA:
undetectable		 2rk8A-5jfmA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		4 ARG A 183
SER A 173
ASP A 444
ALA A 170
 None
 1.38A 2rk8A-5kznA:
undetectable		 2rk8A-5kznA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(Methanotorris
formicicus) 		PF02241
(MCR_beta)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02783
(MCR_beta_N) 		4 ARG B 352
LYS B 387
SER A 461
ASP A 465
 None
 1.19A 2rk8A-5n28B:
undetectable		 2rk8A-5n28B:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owc -

(-) 		no annotation 4 LYS A   1
HIS A  46
ASP A  91
ALA A  53
 None
AYZ  A 202 (-4.0A)
None
None
 1.28A 2rk8A-5owcA:
2.0		 2rk8A-5owcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5w INTERFERON LAMBDA
RECEPTOR 1
INTERFERON LAMBDA-3

(Homo sapiens) 		PF01108
(Tissue_fac)
PF15177
(IL28A) 		4 LYS C  21
LYS C  24
SER B  42
ASP B  98
 None
 1.34A 2rk8A-5t5wC:
3.2		 2rk8A-5t5wC:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5teb RECOGNITION OF
PERONOSPORA
PARASITICA 1

(Arabidopsis
thaliana) 		PF01582
(TIR) 		4 HIS A  98
SER A 157
ASP A 101
ALA A 201
 None
 1.27A 2rk8A-5tebA:
undetectable		 2rk8A-5tebA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		4 HIS C 467
SER C 469
ASP C 360
ALA C 524
 None
 1.41A 2rk8A-5tw1C:
undetectable		 2rk8A-5tw1C:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 HIS A 146
SER A 145
ASP A 345
ALA A 175
 None
 1.38A 2rk8A-5uowA:
undetectable		 2rk8A-5uowA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxl INVASIN IPAD
SINGLE-DOMAIN
ANTIBODY JPS-G3

(Shigella
flexneri;
Vicugna pacos) 		PF06511
(IpaD)
no annotation 		4 LYS A 205
SER B  55
ASP B  52
ALA A 169
 None
 1.26A 2rk8A-5vxlA:
undetectable		 2rk8A-5vxlA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ar3 GSI-IIC RT

(Geobacillus
stearothermophilus) 		no annotation 4 ARG A  63
ASP A  30
ARG A  85
ALA A  26
 U  C   2 ( 2.9A)
None
G  C   4 ( 3.6A)
U  C   3 ( 3.2A)
 1.40A 2rk8A-6ar3A:
undetectable		 2rk8A-6ar3A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0t FASCIN

(Homo sapiens) 		no annotation 4 HIS A 154
SER A 156
ASP A 166
ALA A 160
 None
 1.23A 2rk8A-6b0tA:
undetectable		 2rk8A-6b0tA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5x SUPPRESSOR OF
CYTOKINE SIGNALLING
1

(Xenopus laevis) 		no annotation 4 ARG D 104
HIS D  90
SER D 125
ALA D 114
 None
 0.91A 2rk8A-6c5xD:
undetectable		 2rk8A-6c5xD:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y SUPPRESSOR OF
CYTOKINE SIGNALING 1

(Gallus gallus) 		no annotation 4 ARG B 104
HIS B  90
SER B 125
ALA B 114
 ACT  B 202 (-2.6A)
None
ACT  B 202 ( 4.2A)
ACT  B 202 ( 3.9A)
 0.96A 2rk8A-6c7yB:
undetectable		 2rk8A-6c7yB:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)

(Escherichia
coli) 		no annotation 6 ARG A  65
LYS A 212
LYS A 213
HIS A 232
ASP A 269
ARG A 333
 PYR  A 602 (-4.0A)
PYR  A 602 (-4.5A)
MN  A 604 ( 2.1A)
MN  A 604 ( 3.3A)
MN  A 604 ( 2.5A)
ATP  A 601 ( 2.9A)
 0.91A 2rk8A-6d5iA:
29.3		 2rk8A-6d5iA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)

(Escherichia
coli) 		no annotation 4 LYS A 212
LYS A 213
ARG A 333
ALA A 250
 PYR  A 602 (-4.5A)
MN  A 604 ( 2.1A)
ATP  A 601 ( 2.9A)
ATP  A 601 (-3.3A)
 1.18A 2rk8A-6d5iA:
29.3		 2rk8A-6d5iA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eh1 STRUCTURAL PROTEIN
VP3

(Sacbrood virus) 		no annotation 4 ARG C 180
ASP C 175
ARG C 179
ALA C 208
 None
 1.30A 2rk8A-6eh1C:
undetectable		 2rk8A-6eh1C:
undetectable