SIMILAR PATTERNS OF AMINO ACIDS FOR 2RIW_A_T44A1395

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2h PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00496
(SBP_bac_5) 		5 ALA A 296
LEU A 359
LEU A 293
LEU A 348
ARG A 288
 None
 1.06A 2riwA-1b2hA:
0.0
2riwB-1b2hA:
0.0		 2riwA-1b2hA:
20.84
2riwB-1b2hA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		5 ALA A 311
GLN A 360
LEU A 308
ASN A 300
LEU A 356
 None
 0.97A 2riwA-1dj2A:
undetectable
2riwB-1dj2A:
0.0		 2riwA-1dj2A:
22.25
2riwB-1dj2A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B

(Bacillus
subtilis) 		PF14682
(SPOB_ab)
PF14689
(SPOB_a) 		5 LEU A 146
LEU A 148
LEU A 113
LYS A 112
LEU A 191
 None
 0.83A 2riwA-1f51A:
1.3
2riwB-1f51A:
0.0		 2riwA-1f51A:
20.94
2riwB-1f51A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ALA A 392
LEU A 425
LEU A 354
LEU A 389
LEU A 421
 None
 1.06A 2riwA-1g8xA:
0.0
2riwB-1g8xA:
0.0		 2riwA-1g8xA:
16.87
2riwB-1g8xA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv3 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Thermus
thermophilus) 		PF02542
(YgbB) 		5 ALA A  39
LEU A 129
LEU A  98
LEU A  96
ARG A 145
 None
 1.16A 2riwA-1iv3A:
0.0
2riwB-1iv3A:
undetectable		 2riwA-1iv3A:
18.65
2riwB-1iv3A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ALA A 403
LEU A 436
LEU A 365
LEU A 400
LEU A 432
 None
 1.07A 2riwA-1jx2A:
0.0
2riwB-1jx2A:
0.0		 2riwA-1jx2A:
15.06
2riwB-1jx2A:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1b B-CELL LYMPHOMA
3-ENCODED PROTEIN

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 ALA A 200
LEU A 252
LEU A 253
LEU A 213
ARG A 214
 None
 1.19A 2riwA-1k1bA:
0.0
2riwB-1k1bA:
undetectable		 2riwA-1k1bA:
22.59
2riwB-1k1bA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF07748
(Glyco_hydro_38C) 		5 LEU E 992
LEU E 937
LEU E 896
LEU E 917
ARG E 901
 None
 1.17A 2riwA-1o7dE:
undetectable
2riwB-1o7dE:
0.0		 2riwA-1o7dE:
16.98
2riwB-1o7dE:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9g RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF11599
(AviRa) 		5 LEU A  71
LEU A 100
LYS A  95
ASN A  96
ARG A 108
 None
 1.16A 2riwA-1o9gA:
0.3
2riwB-1o9gA:
0.0		 2riwA-1o9gA:
22.35
2riwB-1o9gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 ALA A  33
LEU A 115
LEU A  90
ASN A 111
LEU A 102
 None
 1.11A 2riwA-1p88A:
0.0
2riwB-1p88A:
0.0		 2riwA-1p88A:
21.07
2riwB-1p88A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 ALA A  33
LEU A 115
LEU A  90
LEU A  60
LEU A 102
 None
 1.07A 2riwA-1p88A:
0.0
2riwB-1p88A:
0.0		 2riwA-1p88A:
21.07
2riwB-1p88A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8r CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUSA

(Escherichia
coli) 		PF05866
(RusA) 		5 ALA A  85
LEU A 110
LEU A 112
LEU A  82
LEU A   8
 None
 1.14A 2riwA-1q8rA:
undetectable
2riwB-1q8rA:
undetectable		 2riwA-1q8rA:
13.80
2riwB-1q8rA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u08 HYPOTHETICAL
AMINOTRANSFERASE
YBDL

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 ALA A 349
GLN A 385
LEU A 386
LEU A 341
LEU A 383
 None
 1.17A 2riwA-1u08A:
undetectable
2riwB-1u08A:
undetectable		 2riwA-1u08A:
22.25
2riwB-1u08A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		5 LEU A 189
LEU A 192
LEU A 285
LEU A 175
ARG A  55
 None
 0.92A 2riwA-1wl1A:
undetectable
2riwB-1wl1A:
undetectable		 2riwA-1wl1A:
22.53
2riwB-1wl1A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		6 ALA A 102
LEU A 133
LEU A 140
LEU A  99
LEU A 178
ARG A 180
 None
 1.18A 2riwA-1xkwA:
undetectable
2riwB-1xkwA:
undetectable		 2riwA-1xkwA:
17.79
2riwB-1xkwA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		5 GLN A 270
LEU A 274
LEU A 273
LEU A 193
LEU A 277
 None
 1.16A 2riwA-1yniA:
undetectable
2riwB-1yniA:
undetectable		 2riwA-1yniA:
22.06
2riwB-1yniA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 ALA A 653
LEU A 615
LEU A 676
LEU A 689
ARG A 644
 None
 1.20A 2riwA-1yq2A:
undetectable
2riwB-1yq2A:
undetectable		 2riwA-1yq2A:
15.37
2riwB-1yq2A:
3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		5 GLN A 441
LEU A 442
LEU A 469
ASN A 470
LEU A 439
 None
 0.96A 2riwA-2braA:
undetectable
2riwB-2braA:
undetectable		 2riwA-2braA:
21.31
2riwB-2braA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwu GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		5 ALA A  80
LEU A  92
LEU A  73
LEU A  13
LEU A  88
 None
 0.99A 2riwA-2dwuA:
undetectable
2riwB-2dwuA:
undetectable		 2riwA-2dwuA:
20.17
2riwB-2dwuA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK

(Mus musculus) 		PF00017
(SH2) 		5 ALA A  79
GLN A  92
LEU A  89
ASN A  97
LEU A  90
 None
 1.15A 2riwA-2eu0A:
undetectable
2riwB-2eu0A:
undetectable		 2riwA-2eu0A:
17.54
2riwB-2eu0A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 ALA A  66
LEU A  45
LEU A  41
LEU A  62
ARG A  19
 None
 1.15A 2riwA-2hxoA:
undetectable
2riwB-2hxoA:
undetectable		 2riwA-2hxoA:
21.30
2riwB-2hxoA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB

(Thermus
thermophilus) 		PF00994
(MoCF_biosynth) 		5 ALA A 149
LEU A 128
LEU A  67
LEU A 146
LEU A 126
 None
 1.20A 2riwA-2is8A:
2.3
2riwB-2is8A:
undetectable		 2riwA-2is8A:
18.86
2riwB-2is8A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 LEU A 218
LEU A 199
ASN A 197
LEU A 331
ARG A 341
 None
 1.20A 2riwA-2iw1A:
undetectable
2riwB-2iw1A:
undetectable		 2riwA-2iw1A:
20.45
2riwB-2iw1A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 LEU A 221
LEU A 218
ASN A 197
LEU A 331
ARG A 341
 None
 1.05A 2riwA-2iw1A:
undetectable
2riwB-2iw1A:
undetectable		 2riwA-2iw1A:
20.45
2riwB-2iw1A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4h DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE

(Escherichia
coli) 		PF00692
(dUTPase) 		5 LEU A  99
LEU A  17
LEU A   3
LEU A 103
ARG A   2
 None
 1.11A 2riwA-2j4hA:
undetectable
2riwB-2j4hA:
undetectable		 2riwA-2j4hA:
19.33
2riwB-2j4hA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3g RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 7

(Homo sapiens) 		PF00307
(CH) 		5 LEU A  24
LEU A  58
LEU A 117
ASN A 118
LEU A  54
 None
 1.16A 2riwA-2l3gA:
undetectable
2riwB-2l3gA:
undetectable		 2riwA-2l3gA:
15.96
2riwB-2l3gA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpe BPSL1050

(Burkholderia
pseudomallei) 		no annotation 5 ALA A  33
LEU A 123
LEU A  70
LEU A  68
ARG A 107
 None
 1.19A 2riwA-2mpeA:
undetectable
2riwB-2mpeA:
undetectable		 2riwA-2mpeA:
17.46
2riwB-2mpeA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		5 ALA A  49
LEU A  62
LEU A  59
LEU A  76
LEU A  30
 None
 1.13A 2riwA-2o0xA:
undetectable
2riwB-2o0xA:
undetectable		 2riwA-2o0xA:
21.56
2riwB-2o0xA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 ALA A  84
LEU A  92
LEU A 102
LEU A  60
LEU A  90
 None
 1.01A 2riwA-2qfqA:
undetectable
2riwB-2qfqA:
undetectable		 2riwA-2qfqA:
22.20
2riwB-2qfqA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq8 TBC1 DOMAIN FAMILY
MEMBER 14

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 ALA A 641
LEU A 580
LEU A 634
LEU A 610
LYS A 609
 None
None
None
UNX  A 202 ( 4.2A)
None
 1.14A 2riwA-2qq8A:
undetectable
2riwB-2qq8A:
undetectable		 2riwA-2qq8A:
22.11
2riwB-2qq8A:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana) 		PF00067
(p450) 		5 ALA A 293
LEU A 175
LEU A 171
LEU A 314
LEU A 174
 None
HEM  A 600 ( 4.9A)
HEM  A 600 (-3.7A)
None
None
 1.20A 2riwA-2rchA:
undetectable
2riwB-2rchA:
undetectable		 2riwA-2rchA:
19.42
2riwB-2rchA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxp TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		5 ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
 None
 0.94A 2riwA-2vxpA:
undetectable
2riwB-2vxpA:
undetectable		 2riwA-2vxpA:
17.07
2riwB-2vxpA:
17.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		7 ALA A  27
GLN A 238
LEU A 246
LEU A 248
LEU A 269
LYS A 270
ASN A 273
 T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 (-4.0A)
T44  A1370 (-4.8A)
T44  A1370 ( 3.3A)
 0.31A 2riwA-2xn6A:
54.1
2riwB-2xn6A:
undetectable		 2riwA-2xn6A:
97.97
2riwB-2xn6A:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xro HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGV

(Pseudomonas
putida) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		5 ALA A 101
LEU A 211
LEU A 110
LEU A  97
LEU A 220
 None
 1.20A 2riwA-2xroA:
undetectable
2riwB-2xroA:
undetectable		 2riwA-2xroA:
23.86
2riwB-2xroA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 LEU A  39
LEU A  36
LEU A 295
LEU A  43
ARG A  44
 None
 1.13A 2riwA-2yijA:
undetectable
2riwB-2yijA:
undetectable		 2riwA-2yijA:
21.40
2riwB-2yijA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn1 LGPCA THIOREDOXIN

(synthetic
construct) 		PF00085
(Thioredoxin) 		5 ALA A  45
LEU A  93
LEU A  77
LEU A  41
LEU A  98
 None
 1.19A 2riwA-2yn1A:
undetectable
2riwB-2yn1A:
undetectable		 2riwA-2yn1A:
17.37
2riwB-2yn1A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		5 LEU A  43
LEU A  40
LEU A  69
LEU A 182
ARG A 179
 None
 1.14A 2riwA-2zq5A:
undetectable
2riwB-2zq5A:
undetectable		 2riwA-2zq5A:
23.02
2riwB-2zq5A:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 ALA A 384
LEU A 401
LEU A 377
LEU A 361
LEU A 403
 None
 1.09A 2riwA-3b2dA:
undetectable
2riwB-3b2dA:
undetectable		 2riwA-3b2dA:
20.55
2riwB-3b2dA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5l REGULATORY PROTEIN
RECX

(Lactobacillus
reuteri) 		PF02631
(RecX) 		5 ALA A  61
LEU A  97
LEU A  83
LYS A  82
LEU A 100
 None
 1.19A 2riwA-3d5lA:
undetectable
2riwB-3d5lA:
undetectable		 2riwA-3d5lA:
21.78
2riwB-3d5lA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Klebsiella
pneumoniae) 		PF06167
(Peptidase_M90) 		5 ALA A  23
LEU A  78
LEU A  75
LEU A  29
LEU A  40
 None
 0.99A 2riwA-3dl1A:
undetectable
2riwB-3dl1A:
undetectable		 2riwA-3dl1A:
20.52
2riwB-3dl1A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Klebsiella
pneumoniae) 		PF06167
(Peptidase_M90) 		5 GLN A 245
LEU A  78
LEU A  75
LEU A  29
LEU A  40
 None
 1.12A 2riwA-3dl1A:
undetectable
2riwB-3dl1A:
undetectable		 2riwA-3dl1A:
20.52
2riwB-3dl1A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 ALA A 711
LEU A 609
LEU A 777
LEU A 707
ARG A 709
 None
 1.19A 2riwA-3g06A:
undetectable
2riwB-3g06A:
undetectable		 2riwA-3g06A:
20.51
2riwB-3g06A:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gku PROBABLE RNA-BINDING
PROTEIN

([Clostridium]
symbiosum) 		PF01424
(R3H)
PF13083
(KH_4)
PF14804
(Jag_N) 		5 ALA A  63
LEU A 111
LEU A 114
LEU A  67
LEU A 134
 None
 1.01A 2riwA-3gkuA:
undetectable
2riwB-3gkuA:
undetectable		 2riwA-3gkuA:
22.64
2riwB-3gkuA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzg PERMEASE
MOLYBDATE-BINDING
PERIPLASMIC PROTEIN

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		5 ALA A 129
LEU A 109
LEU A 166
LEU A 115
ARG A 145
 None
 1.04A 2riwA-3gzgA:
undetectable
2riwB-3gzgA:
undetectable		 2riwA-3gzgA:
21.93
2riwB-3gzgA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 ALA A 696
LEU A 678
LEU A 733
LEU A 670
LEU A 736
 None
UNX  A 908 ( 4.7A)
None
None
None
 1.17A 2riwA-3hzjA:
undetectable
2riwB-3hzjA:
undetectable		 2riwA-3hzjA:
20.22
2riwB-3hzjA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9p MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY A
MEMBER 1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ALA D 555
LEU D 534
LEU D 567
LEU D 518
ARG D 543
 None
 0.97A 2riwA-3j9pD:
undetectable
2riwB-3j9pD:
undetectable		 2riwA-3j9pD:
12.28
2riwB-3j9pD:
2.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l60 BRANCHED-CHAIN
ALPHA-KETO ACID
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00198
(2-oxoacid_dh) 		5 LEU A 202
LEU A 205
LEU A 393
LEU A 221
ARG A 224
 None
 1.17A 2riwA-3l60A:
undetectable
2riwB-3l60A:
undetectable		 2riwA-3l60A:
20.41
2riwB-3l60A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7m 33 KDA CHAPERONIN

(Escherichia
coli) 		PF01430
(HSP33) 		5 ALA X  94
LEU X  30
LEU X  47
ASN X  45
LEU X  34
 None
 1.07A 2riwA-3m7mX:
undetectable
2riwB-3m7mX:
undetectable		 2riwA-3m7mX:
21.97
2riwB-3m7mX:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mt0 UNCHARACTERIZED
PROTEIN PA1789

(Pseudomonas
aeruginosa) 		PF00582
(Usp) 		5 ALA A  24
LEU A  50
LEU A  53
LEU A  21
LEU A  37
 None
 1.00A 2riwA-3mt0A:
undetectable
2riwB-3mt0A:
undetectable		 2riwA-3mt0A:
20.50
2riwB-3mt0A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n53 RESPONSE REGULATOR
RECEIVER MODULATED
DIGUANYLATE CYCLASE

(Pelobacter
carbinolicus) 		PF00072
(Response_reg) 		6 ALA A  36
LEU A  79
LEU A  77
LEU A  66
LYS A  65
LEU A  50
 None
 1.43A 2riwA-3n53A:
undetectable
2riwB-3n53A:
undetectable		 2riwA-3n53A:
19.38
2riwB-3n53A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne9 PHOSPHOPANTETHEINE
PROTEIN TRANSFERASE,
PPT1P

(Corynebacterium
ammoniagenes) 		PF01648
(ACPS) 		5 ALA A 145
LEU A 115
LEU A 132
LYS A  78
LEU A 113
 None
None
None
SO4  A 231 (-2.6A)
None
 1.12A 2riwA-3ne9A:
undetectable
2riwB-3ne9A:
undetectable		 2riwA-3ne9A:
19.12
2riwB-3ne9A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvo NMRA FAMILY PROTEIN

(Shigella
flexneri) 		PF13460
(NAD_binding_10) 		5 ALA A  63
GLN A  82
LEU A  74
LEU A  60
LEU A   7
 None
 1.20A 2riwA-3qvoA:
undetectable
2riwB-3qvoA:
undetectable		 2riwA-3qvoA:
20.80
2riwB-3qvoA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfe PLATELET
GLYCOPROTEIN IB BETA
CHAIN

(Homo sapiens) 		PF01463
(LRRCT) 		5 LEU A 107
LEU A  72
LEU A 104
ARG A 102
ARG A  92
 None
None
None
None
SO4  A 133 (-2.8A)
 0.88A 2riwA-3rfeA:
undetectable
2riwB-3rfeA:
undetectable		 2riwA-3rfeA:
14.50
2riwB-3rfeA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s0x PEPTIDASE A24B, FLAK
DOMAIN PROTEIN

(Methanococcus
maripaludis) 		PF01478
(Peptidase_A24)
PF06847
(Arc_PepC_II) 		5 ALA A 514
LEU A 589
LEU A 586
LEU A 511
LEU A 532
 None
 0.99A 2riwA-3s0xA:
undetectable
2riwB-3s0xA:
undetectable		 2riwA-3s0xA:
21.61
2riwB-3s0xA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v65 AGRIN

(Rattus
norvegicus) 		PF00054
(Laminin_G_1) 		5 ALA A1860
LEU A1920
LEU A1800
LEU A1824
LEU A1798
 None
 0.93A 2riwA-3v65A:
undetectable
2riwB-3v65A:
undetectable		 2riwA-3v65A:
19.30
2riwB-3v65A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 GLN A1813
LEU A1814
LEU A1817
LEU A1925
LEU A1785
 None
 0.92A 2riwA-3vkgA:
undetectable
2riwB-3vkgA:
undetectable		 2riwA-3vkgA:
7.50
2riwB-3vkgA:
1.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN

(Thermoanaerobacter
pseudethanolicus) 		PF01935
(DUF87) 		5 ALA A 406
LEU A 340
LEU A 348
LEU A 403
LEU A 337
 None
 1.20A 2riwA-4ag6A:
undetectable
2riwB-4ag6A:
undetectable		 2riwA-4ag6A:
23.06
2riwB-4ag6A:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 751
LEU A 837
LEU A 880
LEU A 905
LEU A 833
 None
 1.14A 2riwA-4ckrA:
undetectable
2riwB-4ckrA:
undetectable		 2riwA-4ckrA:
21.27
2riwB-4ckrA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1p ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		5 ALA A 614
LEU A 476
LEU A 472
ASN A 629
LEU A 585
 None
 0.92A 2riwA-4f1pA:
undetectable
2riwB-4f1pA:
undetectable		 2riwA-4f1pA:
22.52
2riwB-4f1pA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN

(Xanthomonas
euvesicatoria) 		PF13855
(LRR_8) 		5 LEU A 228
LEU A 208
LEU A 197
LEU A 225
ARG A 224
 None
 1.19A 2riwA-4fcgA:
undetectable
2riwB-4fcgA:
undetectable		 2riwA-4fcgA:
20.39
2riwB-4fcgA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh1 APPA PROTEIN

(Rhodobacter
sphaeroides) 		PF04940
(BLUF) 		5 LEU A 277
LEU A 327
LEU A 350
LEU A 319
ARG A 318
 None
 1.15A 2riwA-4hh1A:
undetectable
2riwB-4hh1A:
undetectable		 2riwA-4hh1A:
22.85
2riwB-4hh1A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Ruegeria
pomeroyi) 		PF00378
(ECH_1) 		5 ALA A 126
LEU A  35
LEU A  43
LEU A  60
LEU A 122
 None
 1.14A 2riwA-4izdA:
undetectable
2riwB-4izdA:
undetectable		 2riwA-4izdA:
22.47
2riwB-4izdA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln1 L-LACTATE
DEHYDROGENASE 1

(Bacillus cereus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A 172
LEU A 200
LEU A 211
LEU A 159
LEU A 196
 None
 1.15A 2riwA-4ln1A:
undetectable
2riwB-4ln1A:
undetectable		 2riwA-4ln1A:
23.74
2riwB-4ln1A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n77 UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		PF09704
(Cas_Cas5d) 		5 ALA A  40
LEU A 137
LEU A 136
LEU A  54
LEU A 140
 None
 1.12A 2riwA-4n77A:
undetectable
2riwB-4n77A:
undetectable		 2riwA-4n77A:
19.94
2riwB-4n77A:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		5 ALA A 238
LEU A 326
ASN A 246
LEU A 275
ARG A 365
 None
 1.11A 2riwA-4o5pA:
undetectable
2riwB-4o5pA:
undetectable		 2riwA-4o5pA:
16.55
2riwB-4o5pA:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 5 LEU A 329
LEU A 238
LEU A 205
LYS A 206
LEU A 272
 None
 0.99A 2riwA-4oj5A:
undetectable
2riwB-4oj5A:
undetectable		 2riwA-4oj5A:
18.53
2riwB-4oj5A:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A1128
LEU A1124
LYS A1107
LEU A1127
ARG A1133
 None
 1.15A 2riwA-4oliA:
undetectable
2riwB-4oliA:
undetectable		 2riwA-4oliA:
19.53
2riwB-4oliA:
4.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p53 CYCLASE

(Streptomyces
hygroscopicus) 		PF01761
(DHQ_synthase) 		5 ALA A  63
LEU A  81
LEU A  52
LEU A  56
LEU A  85
 None
 1.13A 2riwA-4p53A:
undetectable
2riwB-4p53A:
undetectable		 2riwA-4p53A:
20.78
2riwB-4p53A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5i CHEMOKINE BINDING
PROTEIN

(Orf virus) 		PF02250
(Orthopox_35kD) 		5 ALA A  27
LEU A 139
LEU A 236
LEU A 238
ARG A 224
 None
 1.13A 2riwA-4p5iA:
undetectable
2riwB-4p5iA:
undetectable		 2riwA-4p5iA:
22.19
2riwB-4p5iA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2

(Homo sapiens) 		PF08514
(STAG) 		5 ALA A 350
LEU A 324
LEU A 354
LEU A 329
ARG A 370
 None
 1.08A 2riwA-4pjuA:
undetectable
2riwB-4pjuA:
undetectable		 2riwA-4pjuA:
16.07
2riwB-4pjuA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plj CAPSID PROTEIN

(Orthohepevirus
A) 		PF03014
(SP2) 		5 LEU A 471
LEU A 539
LEU A 521
LEU A 601
ARG A 466
 None
 1.04A 2riwA-4pljA:
0.0
2riwB-4pljA:
undetectable		 2riwA-4pljA:
17.06
2riwB-4pljA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pls ARM00010

(synthetic
construct) 		PF00514
(Arm) 		5 LEU A  61
LEU A  58
LEU A  35
LYS A  34
LEU A  20
 None
 1.12A 2riwA-4plsA:
undetectable
2riwB-4plsA:
undetectable		 2riwA-4plsA:
22.46
2riwB-4plsA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3o MGS-MT1

(unidentified) 		PF07859
(Abhydrolase_3) 		5 ALA A 195
LEU A 264
LEU A 269
LEU A 227
ARG A 256
 CL  A 401 ( 4.8A)
None
None
None
None
 0.98A 2riwA-4q3oA:
undetectable
2riwB-4q3oA:
undetectable		 2riwA-4q3oA:
21.39
2riwB-4q3oA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rly NAV1.2 - ANKB
CHIMERA

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 ALA A2240
LEU A2212
LEU A2252
LEU A2196
ARG A2228
 None
 1.04A 2riwA-4rlyA:
undetectable
2riwB-4rlyA:
undetectable		 2riwA-4rlyA:
24.27
2riwB-4rlyA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		5 ALA A 150
LEU A 131
LEU A 187
LEU A 136
ARG A 166
 None
 1.10A 2riwA-4rxlA:
undetectable
2riwB-4rxlA:
undetectable		 2riwA-4rxlA:
22.41
2riwB-4rxlA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txk PROTEIN-METHIONINE
SULFOXIDE OXIDASE
MICAL1

(Mus musculus) 		PF00307
(CH)
PF01494
(FAD_binding_3) 		5 GLN A 441
LEU A 442
LEU A 469
ASN A 470
LEU A 439
 None
 0.98A 2riwA-4txkA:
0.1
2riwB-4txkA:
undetectable		 2riwA-4txkA:
19.77
2riwB-4txkA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzv HEMOGLOBIN

(Thermobifida
fusca) 		PF01152
(Bac_globin) 		6 LEU A 130
LEU A 140
LEU A  83
LEU A  49
ARG A  48
ARG A  80
 None
None
HEM  A1157 (-4.9A)
None
None
None
 1.12A 2riwA-4uzvA:
undetectable
2riwB-4uzvA:
undetectable		 2riwA-4uzvA:
17.63
2riwB-4uzvA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3q YIII_M4_AII

(synthetic
construct) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 LEU A  61
LEU A  58
LEU A  35
LYS A  34
LEU A  20
 None
 1.04A 2riwA-4v3qA:
undetectable
2riwB-4v3qA:
undetectable		 2riwA-4v3qA:
21.64
2riwB-4v3qA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF07034
(ORC3_N) 		5 ALA C 143
LEU C 240
LEU C 238
LEU C 223
LEU C 209
 None
 0.80A 2riwA-4xgcC:
undetectable
2riwB-4xgcC:
undetectable		 2riwA-4xgcC:
22.01
2riwB-4xgcC:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxc FLAGELLAR MOTOR
SWITCH PROTEIN
FLIM,FLAGELLAR MOTOR
SWITCH PROTEIN FLIN

(Salmonella
enterica) 		PF01052
(FliMN_C)
PF16973
(FliN_N) 		5 ALA B  23
LEU B  80
LEU B 171
LEU B  21
LEU B  62
 None
 1.19A 2riwA-4yxcB:
undetectable
2riwB-4yxcB:
undetectable		 2riwA-4yxcB:
20.35
2riwB-4yxcB:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0v 2',5'-PHOSPHODIESTER
ASE 12

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 ALA A 476
GLN A 425
LEU A 429
LEU A 414
LEU A 405
 None
None
None
GOL  A 707 ( 4.0A)
None
 1.16A 2riwA-4z0vA:
undetectable
2riwB-4z0vA:
undetectable		 2riwA-4z0vA:
22.27
2riwB-4z0vA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ALA A 875
GLN A 805
LEU A 833
LYS A 834
ARG A 396
 None
 1.19A 2riwA-5agaA:
undetectable
2riwB-5agaA:
undetectable		 2riwA-5agaA:
18.27
2riwB-5agaA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah0 LIPASE

(Pelosinus
fermentans) 		no annotation 5 LEU A 197
LEU A 292
LEU A  38
LYS A  39
LEU A 201
 None
 1.13A 2riwA-5ah0A:
undetectable
2riwB-5ah0A:
undetectable		 2riwA-5ah0A:
21.20
2riwB-5ah0A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI

(Thermus
thermophilus) 		PF08704
(GCD14) 		5 ALA A 208
LEU A 169
LEU A 178
LEU A 191
ARG A 251
 None
 1.14A 2riwA-5c1iA:
undetectable
2riwB-5c1iA:
undetectable		 2riwA-5c1iA:
22.38
2riwB-5c1iA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 ALA A 477
LEU A 505
LEU A 503
LEU A 523
ASN A 520
 None
 1.03A 2riwA-5cioA:
undetectable
2riwB-5cioA:
undetectable		 2riwA-5cioA:
16.77
2riwB-5cioA:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine leukemia
virus) 		PF00075
(RNase_H)
PF00078
(RVT_1) 		5 ALA A 573
LEU A 509
LEU A 624
LEU A 570
LEU A 630
 None
 1.14A 2riwA-5dmqA:
undetectable
2riwB-5dmqA:
undetectable		 2riwA-5dmqA:
20.49
2riwB-5dmqA:
5.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 361
LEU A 314
LEU A 295
LYS A 338
LEU A 317
 None
 1.19A 2riwA-5fg0A:
undetectable
2riwB-5fg0A:
undetectable		 2riwA-5fg0A:
24.25
2riwB-5fg0A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hso UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887

(Mycobacterium
tuberculosis) 		PF01047
(MarR) 		5 ALA A  76
LEU A  28
LEU A  31
LEU A 102
LEU A  33
 None
 1.14A 2riwA-5hsoA:
undetectable
2riwB-5hsoA:
undetectable		 2riwA-5hsoA:
15.63
2riwB-5hsoA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hso UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887

(Mycobacterium
tuberculosis) 		PF01047
(MarR) 		5 ALA A  78
LEU A  28
LEU A  31
LEU A 102
LEU A  33
 None
 1.00A 2riwA-5hsoA:
undetectable
2riwB-5hsoA:
undetectable		 2riwA-5hsoA:
15.63
2riwB-5hsoA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzl LMO2445 PROTEIN

(Listeria
monocytogenes) 		no annotation 5 ALA B  32
LEU B  96
LEU B  69
LEU B  59
LEU B  72
 None
 1.19A 2riwA-5hzlB:
undetectable
2riwB-5hzlB:
undetectable		 2riwA-5hzlB:
23.24
2riwB-5hzlB:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF

(Thermus
thermophilus) 		no annotation 5 ALA F 726
LEU F 769
LEU F 755
LEU F 646
ARG F 754
 None
 1.09A 2riwA-5it5F:
undetectable
2riwB-5it5F:
undetectable		 2riwA-5it5F:
22.08
2riwB-5it5F:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Streptomyces
sp. ML694-90F3) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA A  84
LEU A  63
LEU A 118
LEU A 120
LEU A  60
 None
 1.08A 2riwA-5jjqA:
undetectable
2riwB-5jjqA:
undetectable		 2riwA-5jjqA:
21.03
2riwB-5jjqA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfb YIII(DQ)4CQI

(synthetic
construct) 		PF00514
(Arm) 		5 LEU A  61
LEU A  58
LEU A  35
LYS A  34
LEU A  20
 None
 1.14A 2riwA-5mfbA:
undetectable
2riwB-5mfbA:
undetectable		 2riwA-5mfbA:
23.86
2riwB-5mfbA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfo YIIIM3AIII

(synthetic
construct) 		PF00514
(Arm) 		5 LEU A  61
LEU A  58
LEU A  35
LYS A  34
LEU A  20
 None
 1.14A 2riwA-5mfoA:
undetectable
2riwB-5mfoA:
undetectable		 2riwA-5mfoA:
21.18
2riwB-5mfoA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE

(Thermobifida
fusca) 		PF03807
(F420_oxidored) 		5 ALA A  77
LEU A 141
LEU A  97
LEU A  25
LEU A 104
 None
 1.16A 2riwA-5n2iA:
undetectable
2riwB-5n2iA:
undetectable		 2riwA-5n2iA:
21.61
2riwB-5n2iA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 5 LEU A   7
LEU A  61
LEU A  43
LYS A  42
LEU A  65
 None
 1.08A 2riwA-5n6vA:
undetectable
2riwB-5n6vA:
undetectable		 2riwA-5n6vA:
12.99
2riwB-5n6vA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		5 ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
 None
 0.97A 2riwA-5nv6A:
undetectable
2riwB-5nv6A:
undetectable		 2riwA-5nv6A:
19.16
2riwB-5nv6A:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		5 ALA A 279
LEU A 329
LEU A 276
ASN A 272
LEU A  35
 None
 1.20A 2riwA-5tj3A:
undetectable
2riwB-5tj3A:
undetectable		 2riwA-5tj3A:
20.72
2riwB-5tj3A:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvm CADHERIN-23

(Homo sapiens) 		no annotation 5 ALA A2209
GLN A2156
LEU A2256
ASN A2172
LEU A2235
 None
 1.10A 2riwA-5vvmA:
undetectable
2riwB-5vvmA:
undetectable		 2riwA-5vvmA:
20.09
2riwB-5vvmA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyd PHOSPHODIESTERASE

(Salpingoeca
rosetta) 		no annotation 5 ALA A 103
LEU A 313
LEU A 303
LEU A 231
LEU A 310
 None
 1.06A 2riwA-5vydA:
undetectable
2riwB-5vydA:
undetectable		 2riwA-5vydA:
22.05
2riwB-5vydA:
12.45