SIMILAR PATTERNS OF AMINO ACIDS FOR 2RHM_D_BEZD194

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum) 		PF00191
(Annexin) 		4 PRO A 248
ILE A 285
ARG A 277
ASP A 281
 SO4  A 806 (-3.8A)
None
None
None
 1.39A 2rhmD-1dk5A:
undetectable		 2rhmD-1dk5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nex CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
D
CDC4 PROTEIN

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01466
(Skp1)
PF03931
(Skp1_POZ)
PF00400
(WD40)
PF12937
(F-box-like) 		4 PRO A 163
ILE A 166
ARG A 161
ASP B 294
 None
 1.50A 2rhmD-1nexA:
undetectable		 2rhmD-1nexA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 PRO A 125
ILE A 111
ARG A 120
ASP A 112
 None
 1.49A 2rhmD-1rx0A:
undetectable		 2rhmD-1rx0A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 PRO A 372
ILE A 306
ARG A 374
ASP A 307
 None
 1.40A 2rhmD-1rzvA:
0.9		 2rhmD-1rzvA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vim HYPOTHETICAL PROTEIN
AF1796

(Archaeoglobus
fulgidus) 		PF01380
(SIS) 		4 PRO A  72
ILE A  74
ARG A  35
ASP A  78
 None
 1.46A 2rhmD-1vimA:
2.5		 2rhmD-1vimA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vim HYPOTHETICAL PROTEIN
AF1796

(Archaeoglobus
fulgidus) 		PF01380
(SIS) 		4 PRO A  72
ILE A  74
ARG A  73
ASP A  78
 None
 1.24A 2rhmD-1vimA:
2.5		 2rhmD-1vimA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		4 PRO A  96
ILE A 112
ARG A 160
ASP A 111
 None
 1.36A 2rhmD-1wpwA:
2.7		 2rhmD-1wpwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xz9 AFADIN

(Homo sapiens) 		PF00595
(PDZ) 		4 PRO A  10
ILE A  13
ARG A  56
ASP A  61
 None
 1.16A 2rhmD-1xz9A:
undetectable		 2rhmD-1xz9A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		4 PRO A 496
ILE A 540
ARG A 541
ASP A 539
 None
 1.25A 2rhmD-1z7eA:
2.8		 2rhmD-1z7eA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bll PROTEIN YFBG

(Escherichia
coli) 		PF01370
(Epimerase) 		4 PRO A 496
ILE A 540
ARG A 541
ASP A 539
 None
 1.31A 2rhmD-2bllA:
2.1		 2rhmD-2bllA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		4 PRO A  70
ARG A  40
ARG A  39
ASP A 137
 None
FAD  A 500 (-4.0A)
FAD  A 500 (-3.6A)
FAD  A 500 (-4.2A)
 1.43A 2rhmD-2gv8A:
1.8		 2rhmD-2gv8A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		4 PRO A 454
ARG A 296
ARG A 297
ASP A 294
 None
 1.30A 2rhmD-2i3oA:
undetectable		 2rhmD-2i3oA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzl CYANOVIRIN-N HOMOLOG

(Neurospora
crassa) 		PF08881
(CVNH) 		4 ILE A  20
ARG A  15
ARG A  18
ASP A  40
 None
 1.10A 2rhmD-2jzlA:
undetectable		 2rhmD-2jzlA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B

(Bos taurus) 		PF00400
(WD40) 		4 PRO C 140
ILE C 141
ARG C 142
ASP C 163
 None
 1.40A 2rhmD-2p9nC:
undetectable		 2rhmD-2p9nC:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1k PUTATIVE SORTASE

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		4 PRO A 131
ILE A 137
ARG A 222
ASP A 133
 None
None
MES  A1243 (-2.7A)
MES  A1243 (-3.3A)
 1.48A 2rhmD-2w1kA:
undetectable		 2rhmD-2w1kA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0k PYROGLUTATMATE PORIN
OPDO

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 PRO A 270
ILE A 168
ARG A 167
ASP A 267
 None
 1.37A 2rhmD-2y0kA:
undetectable		 2rhmD-2y0kA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymb MIT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF16565
(MIT_C) 		4 PRO A 123
ILE A 125
ARG A 126
ASP A 212
 None
 1.44A 2rhmD-2ymbA:
undetectable		 2rhmD-2ymbA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 PRO B 509
ILE B 511
ARG B 510
ASP B 505
 None
 1.12A 2rhmD-2z7xB:
undetectable		 2rhmD-2z7xB:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zay RESPONSE REGULATOR
RECEIVER PROTEIN

(Desulfuromonas
acetoxidans) 		PF00072
(Response_reg) 		4 ILE A 109
ARG A 117
ARG A 121
ASP A 107
 None
 1.27A 2rhmD-2zayA:
3.4		 2rhmD-2zayA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		PF00073
(Rhv) 		4 PRO B 174
ILE B 172
ARG B 178
ASP B 191
 None
 1.40A 2rhmD-3cjiB:
undetectable		 2rhmD-3cjiB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eu8 PUTATIVE
GLUCOAMYLASE

(Bacteroides
fragilis) 		PF10091
(Glycoamylase)
PF11329
(DUF3131) 		4 PRO A  76
ARG A  68
ARG A 407
ASP A  72
 EDO  A 454 (-4.1A)
EDO  A 472 (-2.8A)
EDO  A 454 (-3.2A)
None
 1.33A 2rhmD-3eu8A:
undetectable		 2rhmD-3eu8A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00575
(S1)
PF03876
(SHS2_Rpb7-N) 		4 PRO G  64
ILE A1449
ARG G  61
ASP A1448
 None
 0.99A 2rhmD-3h0gG:
undetectable		 2rhmD-3h0gG:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwz CATABOLITE
ACTIVATION-LIKE
PROTEIN

(Xanthomonas
campestris) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		4 PRO A 131
ILE A 133
ARG A 132
ASP A 129
 None
 1.40A 2rhmD-3iwzA:
undetectable		 2rhmD-3iwzA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtz INTEGRASE

(Yersinia pestis) 		PF13356
(Arm-DNA-bind_3) 		4 PRO A  57
ILE A   8
ARG A   9
ASP A   5
 None
 1.28A 2rhmD-3jtzA:
undetectable		 2rhmD-3jtzA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS

(Escherichia
coli) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 PRO A 649
ILE A 650
ARG A 316
ASP A 651
 None
 1.49A 2rhmD-3k0sA:
2.1		 2rhmD-3k0sA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE

(Bordetella
bronchiseptica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 PRO A  26
ILE A 345
ARG A 349
ASP A 346
 None
 1.38A 2rhmD-3moiA:
undetectable		 2rhmD-3moiA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvn PLEXIN-C1

(Homo sapiens) 		PF01437
(PSI) 		4 ILE B 437
ARG B 451
ARG B 449
ASP B 432
 None
 0.97A 2rhmD-3nvnB:
undetectable		 2rhmD-3nvnB:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oby PROTEIN PELOTA
HOMOLOG

(Archaeoglobus
fulgidus) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 PRO A 324
ILE A 253
ARG A 327
ASP A 254
 None
 1.41A 2rhmD-3obyA:
undetectable		 2rhmD-3obyA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT

(Mycobacterium
marinum) 		PF00202
(Aminotran_3) 		4 PRO A  75
ILE A  70
ARG A  76
ASP A 341
 None
 1.34A 2rhmD-3r4tA:
undetectable		 2rhmD-3r4tA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uif SULFONATE ABC
TRANSPORTER,
PERIPLASMIC
SULFONATE-BINDING
PROTEIN SSUA

(Methylobacillus
flagellatus) 		PF09084
(NMT1) 		4 PRO A 273
ILE A 200
ARG A 279
ASP A 203
 SO4  A 502 (-4.3A)
None
None
None
 1.24A 2rhmD-3uifA:
undetectable		 2rhmD-3uifA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 PRO A1032
ILE A1034
ARG A1291
ASP A1028
 None
 1.32A 2rhmD-3ummA:
2.7		 2rhmD-3ummA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5z MIT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF16565
(MIT_C) 		4 PRO A 123
ILE A 125
ARG A 126
ASP A 212
 None
 1.37A 2rhmD-4a5zA:
undetectable		 2rhmD-4a5zA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		4 PRO A 313
ILE A 340
ARG A 338
ASP A 341
 None
 1.27A 2rhmD-4fixA:
undetectable		 2rhmD-4fixA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g12 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
TETR-FAMILY)

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 ILE A 122
ARG A 121
ARG A 125
ASP A 126
 None
 1.12A 2rhmD-4g12A:
undetectable		 2rhmD-4g12A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4het HYPOTHETICAL
GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13201
(PCMD) 		4 PRO A 306
ILE A 304
ARG A 303
ASP A 272
 None
 0.98A 2rhmD-4hetA:
undetectable		 2rhmD-4hetA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrl PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
ovatus) 		PF13201
(PCMD) 		4 PRO A 307
ILE A 305
ARG A 304
ASP A 273
 None
 1.06A 2rhmD-4jrlA:
undetectable		 2rhmD-4jrlA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k46 ADENYLATE KINASE

(Photobacterium
profundum) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 PRO A   9
ARG A 119
ARG A 123
ASP A 159
 None
ADP  A 301 (-3.6A)
ADP  A 301 (-3.6A)
None
 0.93A 2rhmD-4k46A:
12.0		 2rhmD-4k46A:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8b YHR177W

(Saccharomyces
cerevisiae) 		PF09729
(Gti1_Pac2) 		4 PRO R 157
ILE R  11
ARG R 156
ASP R  13
 None
 1.50A 2rhmD-4m8bR:
undetectable		 2rhmD-4m8bR:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nav HYPOTHETICAL PROTEIN
XCC279

(Xanthomonas
campestris) 		no annotation 4 PRO D 140
ILE D 142
ARG D 145
ASP D 119
 None
 1.37A 2rhmD-4navD:
undetectable		 2rhmD-4navD:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pib INCLUSION BODY
PROTEIN

(Burkholderia
thailandensis) 		PF12306
(PixA) 		4 PRO A  63
ILE A  19
ARG A  64
ASP A  83
 None
 1.40A 2rhmD-4pibA:
undetectable		 2rhmD-4pibA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdd 3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE

(Rhodococcus
rhodochrous) 		PF00355
(Rieske) 		4 PRO A 320
ILE A 321
ARG A 176
ASP A 322
 None
 1.50A 2rhmD-4qddA:
undetectable		 2rhmD-4qddA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Listeria
monocytogenes) 		PF00574
(CLP_protease) 		4 PRO H 161
ILE H 165
ARG H 167
ASP H 168
 None
 1.30A 2rhmD-4ryfH:
undetectable		 2rhmD-4ryfH:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0z ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD

(Homo sapiens) 		PF02661
(Fic) 		4 PRO A 413
ILE A 157
ARG A 412
ASP A 160
 None
 1.46A 2rhmD-4u0zA:
undetectable		 2rhmD-4u0zA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 PRO A 764
ILE A 744
ARG A 733
ASP A 742
 None
 1.31A 2rhmD-4xhjA:
undetectable		 2rhmD-4xhjA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyq FICIN ISOFORM A

(Ficus carica) 		PF00112
(Peptidase_C1) 		4 ILE A 165
ARG A 179
ARG A   8
ASP A   6
 None
 1.49A 2rhmD-4yyqA:
undetectable		 2rhmD-4yyqA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yys FICIN ISOFORM B

(Ficus carica) 		PF00112
(Peptidase_C1) 		4 ILE A 167
ARG A 181
ARG A   8
ASP A   6
 None
 1.47A 2rhmD-4yysA:
undetectable		 2rhmD-4yysA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		4 PRO K 579
ILE K  19
ARG K 510
ASP K 111
 None
 1.38A 2rhmD-5anbK:
2.0		 2rhmD-5anbK:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxy RNA
METHYLTRANSFERASE

(Salinibacter
ruber) 		PF13847
(Methyltransf_31) 		4 ILE A  39
ARG A  40
ARG A  36
ASP A  34
 None
 1.05A 2rhmD-5bxyA:
undetectable		 2rhmD-5bxyA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exk LIPOYL SYNTHASE

(Mycobacterium
tuberculosis) 		PF04055
(Radical_SAM)
PF16881
(LIAS_N) 		4 PRO A 193
ILE A 191
ARG A 192
ASP A  86
 None
None
MET  A 404 ( 2.9A)
IMD  A 405 (-3.9A)
 1.50A 2rhmD-5exkA:
1.5		 2rhmD-5exkA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP3

(Deformed wing
virus) 		PF00073
(Rhv) 		4 PRO C  98
ILE C 314
ARG C 328
ASP C 316
 None
 1.43A 2rhmD-5g52C:
undetectable		 2rhmD-5g52C:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 ILE A1321
ARG A1292
ARG A1311
ASP A1318
 None
 1.39A 2rhmD-5i6hA:
0.9		 2rhmD-5i6hA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 ILE A1321
ARG A1292
ARG A1311
ASP A1318
 None
 1.44A 2rhmD-5i6iA:
undetectable		 2rhmD-5i6iA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae) 		PF00154
(RecA) 		4 PRO A  74
ILE A 232
ARG A 233
ASP A 231
 None
 1.26A 2rhmD-5jrjA:
2.5		 2rhmD-5jrjA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE

(Xenopus
tropicalis) 		no annotation 4 ILE A  89
ARG A 103
ARG A 107
ASP A 203
 EDO  A 404 ( 4.2A)
None
EDO  A 404 ( 3.9A)
EDO  A 404 (-3.6A)
 1.24A 2rhmD-5oj7A:
undetectable		 2rhmD-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		4 PRO A 635
ARG A 693
ARG A 690
ASP A 686
 None
 1.33A 2rhmD-5ubkA:
undetectable		 2rhmD-5ubkA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 4 PRO A 555
ILE A 515
ARG A 570
ASP A 548
 None
 1.46A 2rhmD-5xioA:
undetectable		 2rhmD-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj4 MAJOR PRION PROTEIN

(Homo sapiens) 		no annotation 4 ILE A 138
ARG A 136
ARG A 151
ASP A 147
 None
 1.31A 2rhmD-5yj4A:
undetectable		 2rhmD-5yj4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 4 ILE A 581
ARG A 625
ARG A 628
ASP A 582
 None
None
ADP  A1001 (-2.6A)
None
 1.41A 2rhmD-6fa5A:
undetectable		 2rhmD-6fa5A:
undetectable