SIMILAR PATTERNS OF AMINO ACIDS FOR 2RHM_B_BEZB194

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		4 PRO A 418
ILE A 420
ARG A 419
ASP A 416
 None
 1.45A 2rhmB-1cbgA:
undetectable		 2rhmB-1cbgA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum) 		PF00191
(Annexin) 		4 PRO A 248
ILE A 285
ARG A 277
ASP A 281
 SO4  A 806 (-3.8A)
None
None
None
 1.25A 2rhmB-1dk5A:
undetectable		 2rhmB-1dk5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
SMALL SUBUNIT
[NIFE] HYDROGENASE
LARGE SUBUNIT

(Desulfovibrio
desulfuricans;
Desulfovibrio
desulfuricans) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
PF00374
(NiFeSe_Hases) 		4 PRO A  30
ILE A  32
ARG B 207
ASP A  33
 None
 0.79A 2rhmB-1e3dA:
2.2		 2rhmB-1e3dA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 PRO A 125
ILE A 111
ARG A 120
ASP A 112
 None
 1.43A 2rhmB-1rx0A:
undetectable		 2rhmB-1rx0A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG

(Bacillus
subtilis) 		PF05343
(Peptidase_M42) 		4 PRO A 245
ILE A 247
ARG A 322
ASP A 243
 None
 1.44A 2rhmB-1vheA:
3.2		 2rhmB-1vheA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vim HYPOTHETICAL PROTEIN
AF1796

(Archaeoglobus
fulgidus) 		PF01380
(SIS) 		4 PRO A  72
ILE A  74
ARG A  35
ASP A  78
 None
 1.41A 2rhmB-1vimA:
2.6		 2rhmB-1vimA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vim HYPOTHETICAL PROTEIN
AF1796

(Archaeoglobus
fulgidus) 		PF01380
(SIS) 		4 PRO A  72
ILE A  74
ARG A  73
ASP A  78
 None
 1.22A 2rhmB-1vimA:
2.6		 2rhmB-1vimA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		4 PRO A  96
ILE A 112
ARG A 160
ASP A 111
 None
 1.40A 2rhmB-1wpwA:
2.1		 2rhmB-1wpwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		4 PRO A 243
ILE A 280
ARG A 272
ASP A 276
 None
 1.34A 2rhmB-1ycnA:
undetectable		 2rhmB-1ycnA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		4 PRO A 496
ILE A 540
ARG A 541
ASP A 539
 None
 1.36A 2rhmB-1z7eA:
3.3		 2rhmB-1z7eA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bll PROTEIN YFBG

(Escherichia
coli) 		PF01370
(Epimerase) 		4 PRO A 496
ILE A 540
ARG A 541
ASP A 539
 None
 1.39A 2rhmB-2bllA:
2.3		 2rhmB-2bllA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		4 PRO A  70
ARG A  40
ARG A  39
ASP A 137
 None
FAD  A 500 (-4.0A)
FAD  A 500 (-3.6A)
FAD  A 500 (-4.2A)
 1.41A 2rhmB-2gv8A:
1.8		 2rhmB-2gv8A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kj8 PUTATIVE PROPHAGE
CPS-53 INTEGRASE

(Escherichia
coli) 		PF14659
(Phage_int_SAM_3) 		4 PRO A  40
ILE A  38
ARG A  61
ASP A  37
 None
 1.17A 2rhmB-2kj8A:
undetectable		 2rhmB-2kj8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf2 MRNA INTERFERASE
MAZF

(Staphylococcus
aureus) 		PF02452
(PemK_toxin) 		4 PRO A  26
ARG A  92
ARG A  98
ASP A  23
 None
 1.34A 2rhmB-2mf2A:
undetectable		 2rhmB-2mf2A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw8 EUGENOL SYNTHASE 1

(Ocimum
basilicum) 		PF05368
(NmrA) 		4 PRO A  86
ILE A  88
ARG A 131
ASP A  90
 None
 1.27A 2rhmB-2qw8A:
undetectable		 2rhmB-2qw8A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjt ALLOPHYCOCYANIN
ALPHA SUBUNIT

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		4 ILE A  39
ARG A  36
ARG A  35
ASP A 145
 None
 1.22A 2rhmB-2vjtA:
undetectable		 2rhmB-2vjtA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 PRO A  69
ILE A  66
ARG A  65
ASP A  67
 None
 1.43A 2rhmB-2x2iA:
undetectable		 2rhmB-2x2iA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0k PYROGLUTATMATE PORIN
OPDO

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 PRO A 270
ILE A 168
ARG A 167
ASP A 267
 None
 1.34A 2rhmB-2y0kA:
undetectable		 2rhmB-2y0kA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 PRO B 509
ILE B 511
ARG B 510
ASP B 505
 None
 1.22A 2rhmB-2z7xB:
undetectable		 2rhmB-2z7xB:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE

(Trypanosoma
vivax) 		PF01156
(IU_nuc_hydro) 		4 PRO A 270
ILE A 271
ARG A 205
ASP A 272
 None
 1.49A 2rhmB-3b9gA:
undetectable		 2rhmB-3b9gA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm3 PSPGI RESTRICTION
ENDONUCLEASE

(Pyrococcus sp.
GI-H) 		PF09019
(EcoRII-C) 		4 ILE A 249
ARG A 211
ARG A 244
ASP A 248
 None
 1.34A 2rhmB-3bm3A:
undetectable		 2rhmB-3bm3A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brx ANNEXIN

(Gossypium
hirsutum) 		PF00191
(Annexin) 		4 PRO A 247
ILE A 284
ARG A 276
ASP A 280
 None
 1.26A 2rhmB-3brxA:
undetectable		 2rhmB-3brxA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		PF00073
(Rhv) 		4 PRO B 174
ILE B 172
ARG B 178
ASP B 191
 None
 1.42A 2rhmB-3cjiB:
undetectable		 2rhmB-3cjiB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6e ALANINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 PRO A 126
ILE A  98
ARG A 128
ASP A 101
 None
 1.30A 2rhmB-3e6eA:
undetectable		 2rhmB-3e6eA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00575
(S1)
PF03876
(SHS2_Rpb7-N) 		4 PRO G  64
ILE A1449
ARG G  61
ASP A1448
 None
 0.88A 2rhmB-3h0gG:
undetectable		 2rhmB-3h0gG:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwz CATABOLITE
ACTIVATION-LIKE
PROTEIN

(Xanthomonas
campestris) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		4 PRO A 131
ILE A 133
ARG A 132
ASP A 129
 None
 1.31A 2rhmB-3iwzA:
undetectable		 2rhmB-3iwzA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j40 GP7

(Salmonella
virus Epsilon15) 		no annotation 4 ILE A  14
ARG A  17
ARG A  26
ASP A  19
 None
 1.31A 2rhmB-3j40A:
undetectable		 2rhmB-3j40A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtz INTEGRASE

(Yersinia pestis) 		PF13356
(Arm-DNA-bind_3) 		4 PRO A  57
ILE A   8
ARG A   9
ASP A   5
 None
 1.30A 2rhmB-3jtzA:
undetectable		 2rhmB-3jtzA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kda CFTR INHIBITORY
FACTOR (CIF)

(Pseudomonas
aeruginosa) 		no annotation 4 PRO D 122
ILE D 146
ARG D 115
ASP D 145
 None
 1.46A 2rhmB-3kdaD:
2.6		 2rhmB-3kdaD:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C

(Thermus
thermophilus;
Thermus
thermophilus) 		PF01425
(Amidase)
PF02686
(Glu-tRNAGln) 		4 ILE G  35
ARG E 341
ARG E 340
ASP G  31
 None
 1.40A 2rhmB-3kfuG:
undetectable		 2rhmB-3kfuG:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv8 THYMIDYLATE KINASE

(Vibrio cholerae) 		PF02223
(Thymidylate_kin) 		4 ILE A 198
ARG A 199
ARG A 200
ASP A 197
 None
 1.33A 2rhmB-3lv8A:
10.8		 2rhmB-3lv8A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE

(Bordetella
bronchiseptica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 PRO A  26
ILE A 345
ARG A 349
ASP A 346
 None
 1.42A 2rhmB-3moiA:
undetectable		 2rhmB-3moiA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrd HISTIDINE TRIAD
(HIT) PROTEIN

(Sinorhizobium
meliloti) 		PF01230
(HIT) 		4 PRO A  40
ILE A  45
ARG A  42
ASP A  55
 None
 1.49A 2rhmB-3nrdA:
undetectable		 2rhmB-3nrdA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 PRO A 240
ILE A 241
ARG A 209
ASP A 208
 None
 1.47A 2rhmB-3qdeA:
undetectable		 2rhmB-3qdeA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT

(Mycobacterium
marinum) 		PF00202
(Aminotran_3) 		4 PRO A  75
ILE A  70
ARG A  76
ASP A 341
 None
 1.38A 2rhmB-3r4tA:
undetectable		 2rhmB-3r4tA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uif SULFONATE ABC
TRANSPORTER,
PERIPLASMIC
SULFONATE-BINDING
PROTEIN SSUA

(Methylobacillus
flagellatus) 		PF09084
(NMT1) 		4 PRO A 273
ILE A 200
ARG A 279
ASP A 203
 SO4  A 502 (-4.3A)
None
None
None
 1.22A 2rhmB-3uifA:
undetectable		 2rhmB-3uifA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 PRO A1032
ILE A1034
ARG A1291
ASP A1028
 None
 1.33A 2rhmB-3ummA:
undetectable		 2rhmB-3ummA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		4 PRO A 109
ILE A 120
ARG A 122
ASP A 106
 None
 1.48A 2rhmB-3wa1A:
undetectable		 2rhmB-3wa1A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5z MIT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF16565
(MIT_C) 		4 PRO A 123
ILE A 125
ARG A 126
ASP A 212
 None
 1.37A 2rhmB-4a5zA:
undetectable		 2rhmB-4a5zA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6q HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP18

(Mus musculus) 		PF06487
(SAP18) 		4 PRO A  19
ILE A  20
ARG A  22
ASP A  21
 None
 1.34A 2rhmB-4a6qA:
undetectable		 2rhmB-4a6qA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6u OMEGA TRANSAMINASE

(Chromobacterium
violaceum) 		PF00202
(Aminotran_3) 		4 PRO A 354
ILE A 352
ARG A 432
ASP A 351
 None
 1.35A 2rhmB-4a6uA:
undetectable		 2rhmB-4a6uA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 PRO A 751
ARG A 808
ARG A 742
ASP A 723
 None
EDO  A1832 (-3.9A)
None
None
 1.22A 2rhmB-4b9yA:
undetectable		 2rhmB-4b9yA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 4 PRO A 866
ILE A 846
ARG A 847
ASP A 845
 None
 1.50A 2rhmB-4ecoA:
undetectable		 2rhmB-4ecoA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		4 PRO A 313
ILE A 340
ARG A 338
ASP A 341
 None
 1.35A 2rhmB-4fixA:
undetectable		 2rhmB-4fixA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g12 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
TETR-FAMILY)

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 ILE A 122
ARG A 121
ARG A 125
ASP A 126
 None
 0.99A 2rhmB-4g12A:
undetectable		 2rhmB-4g12A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4het HYPOTHETICAL
GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13201
(PCMD) 		4 PRO A 306
ILE A 304
ARG A 303
ASP A 272
 None
 1.02A 2rhmB-4hetA:
undetectable		 2rhmB-4hetA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Dickeya
paradisiaca) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PRO A 285
ILE A 257
ARG A 261
ASP A 258
 None
 0.96A 2rhmB-4ihcA:
undetectable		 2rhmB-4ihcA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrl PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
ovatus) 		PF13201
(PCMD) 		4 PRO A 307
ILE A 305
ARG A 304
ASP A 273
 None
 1.10A 2rhmB-4jrlA:
undetectable		 2rhmB-4jrlA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mct KILLER PROTEIN

(Proteus
vulgaris) 		PF05015
(HigB-like_toxin) 		4 ILE B  30
ARG B  33
ARG B  29
ASP B  26
 None
 1.48A 2rhmB-4mctB:
undetectable		 2rhmB-4mctB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdd 3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE

(Rhodococcus
rhodochrous) 		PF00355
(Rieske) 		4 PRO A 320
ILE A 321
ARG A 176
ASP A 322
 None
 1.49A 2rhmB-4qddA:
undetectable		 2rhmB-4qddA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhx UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		PF11958
(DUF3472)
PF16871
(DUF5077) 		4 PRO A  66
ILE A 109
ARG A 110
ASP A 108
 None
 1.33A 2rhmB-4qhxA:
undetectable		 2rhmB-4qhxA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rj9 C2 DOMAIN-CONTAINING
PROTEIN-LIKE

(Oryza sativa) 		PF00168
(C2) 		4 PRO A  67
ILE A  90
ARG A  91
ASP A  89
 None
 1.21A 2rhmB-4rj9A:
undetectable		 2rhmB-4rj9A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Listeria
monocytogenes) 		PF00574
(CLP_protease) 		4 PRO H 161
ILE H 165
ARG H 167
ASP H 168
 None
 1.35A 2rhmB-4ryfH:
undetectable		 2rhmB-4ryfH:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PRO A  43
ILE A  45
ARG A  44
ASP A  41
 None
None
TRS  A1350 ( 4.1A)
None
 1.29A 2rhmB-4uekA:
2.7		 2rhmB-4uekA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wip SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-2

(Homo sapiens) 		PF00778
(DIX) 		4 PRO A  32
ILE A  38
ARG A  37
ASP A  42
 None
 1.31A 2rhmB-4wipA:
undetectable		 2rhmB-4wipA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wip SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-2

(Homo sapiens) 		PF00778
(DIX) 		4 PRO A  34
ILE A  38
ARG A  77
ASP A  42
 None
 1.45A 2rhmB-4wipA:
undetectable		 2rhmB-4wipA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 PRO A 764
ILE A 744
ARG A 733
ASP A 742
 None
 1.16A 2rhmB-4xhjA:
undetectable		 2rhmB-4xhjA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8f GENOME POLYPHUMAN
SAFFOLD VIRUS-3 VP3
PROTEIN

(Cardiovirus B) 		PF00073
(Rhv) 		4 PRO B 168
ILE B 166
ARG B 172
ASP B 185
 None
 1.43A 2rhmB-5a8fB:
undetectable		 2rhmB-5a8fB:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		4 PRO K 579
ILE K  19
ARG K 510
ASP K 111
 None
 1.41A 2rhmB-5anbK:
undetectable		 2rhmB-5anbK:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 4 PRO A 915
ILE A 911
ARG A 910
ASP A 912
 None
 1.48A 2rhmB-5b7iA:
2.6		 2rhmB-5b7iA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxy RNA
METHYLTRANSFERASE

(Salinibacter
ruber) 		PF13847
(Methyltransf_31) 		4 ILE A  39
ARG A  40
ARG A  36
ASP A  34
 None
 0.86A 2rhmB-5bxyA:
undetectable		 2rhmB-5bxyA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfc VP3

(Cardiovirus B) 		PF00073
(Rhv) 		4 PRO B 168
ILE B 166
ARG B 172
ASP B 185
 None
 1.43A 2rhmB-5cfcB:
undetectable		 2rhmB-5cfcB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		4 PRO A 632
ILE A 635
ARG A 593
ASP A 588
 None
 1.45A 2rhmB-5e7pA:
2.8		 2rhmB-5e7pA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foz LARVICIDAL TOXIN
PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		4 PRO B 109
ILE B 120
ARG B 122
ASP B 106
 None
 1.38A 2rhmB-5fozB:
undetectable		 2rhmB-5fozB:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP3

(Deformed wing
virus) 		PF00073
(Rhv) 		4 PRO C  98
ILE C 314
ARG C 328
ASP C 316
 None
 1.40A 2rhmB-5g52C:
undetectable		 2rhmB-5g52C:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 ILE A1321
ARG A1292
ARG A1311
ASP A1318
 None
 1.40A 2rhmB-5i6hA:
undetectable		 2rhmB-5i6hA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 ILE A1321
ARG A1292
ARG A1311
ASP A1318
 None
 1.39A 2rhmB-5i6iA:
2.0		 2rhmB-5i6iA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8j NEW ANTIGEN RECEPTOR
VARIABLE DOMAIN

(Orectolobus
maculatus) 		PF07686
(V-set) 		4 ILE B  87
ARG B  93
ARG B  94
ASP B  88
 None
 1.26A 2rhmB-5l8jB:
undetectable		 2rhmB-5l8jB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7f MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1,ANNEXIN A2

(Homo sapiens) 		no annotation 4 ILE A 610
ARG A 607
ARG A 602
ASP A 577
 None
 1.49A 2rhmB-5n7fA:
undetectable		 2rhmB-5n7fA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE

(Xenopus
tropicalis) 		no annotation 4 ILE A  89
ARG A 103
ARG A 107
ASP A 203
 EDO  A 404 ( 4.2A)
None
EDO  A 404 ( 3.9A)
EDO  A 404 (-3.6A)
 1.21A 2rhmB-5oj7A:
undetectable		 2rhmB-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Toxoplasma
gondii) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 PRO A 427
ILE A 425
ARG A 420
ASP A 424
 None
 1.33A 2rhmB-5t0lA:
undetectable		 2rhmB-5t0lA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 4 ILE A 581
ARG A 625
ARG A 628
ASP A 582
 None
None
ADP  A1001 (-2.6A)
None
 1.44A 2rhmB-6fa5A:
undetectable		 2rhmB-6fa5A:
undetectable